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TDMS Study 56111-03 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/18/01       
EXPERIMENT: 56111 TEST: 03                                                                                     TIME: 13:39:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: TOFT, JOHN                                                                                        CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  TRANS-CINNAMALDEHYDE                                                                            
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Brain                                  Hemorrhage                                                                                   
Liver                                  Mixed Cell Focus                                                                             
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Inflammation Chronic                                                                         
Oral Mucosa: Gingival                  Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
Preputial Gland                        Hyperplasia                                                                                  
                                       Inflammation Chronic                                                                         
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Heart                                  Cardiomyopathy                                                                               
Mesentery: Fat                         Inflammation Chronic                                                                         
Pancreas: Duct                         Cyst                                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)    |           1/50 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.58                  0/41.64      |           1/45.04                  2/45.91         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%         |           2.2%                     4.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           1/34 (3%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  696                      ---          |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.528N     |                                    P=0.520         | 
|POLY 3             |                                           P=0.528N     |                                    P=0.504         | 
|POLY 1.5           |                                           P=0.517N     |                                    P=0.504         | 
|POLY 6             |                                           P=0.540N     |                                    P=0.506         | 
|LOGISTIC REGRESSION|                                           P=0.506N     |                                    P=0.520         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  2/41.64      |           2/45.55                  1/45.91         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.8%         |           4.4%                     2.2%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/31 (7%)    |           0/34 (0%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           597                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.523      |                                    P=0.488N        | 
|POLY 3             |                                           P=0.485      |                                    P=0.496N        | 
|POLY 1.5           |                                           P=0.491      |                                    P=0.496N        | 
|POLY 6             |                                           P=0.480      |                                    P=0.498N        | 
|LOGISTIC REGRESSION|                                           P=0.523      |                                    P=0.519N        | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  12/50 (24%)              9/50 (18%)   |           10/50 (20%)              17/50 (34%)     | 
|POLY-3 RATE (b)    |                  12/45.05                 9/42.63      |           10/45.31                 17/46.54        | 
|POLY-3 PERCENT (g) |                  26.6%                    21.1%        |           22.1%                    36.5%           | 
|TERMINAL (d)       |                  9/29 (31%)               6/31 (19%)   |           8/34 (24%)               14/36 (39%)     | 
|FIRST INCIDENCE    |                  603                      577          |           676                      652             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.287N     |                                    P=0.120         | 
|POLY 3             |                                           P=0.363N     |                                    P=0.095         | 
|POLY 1.5           |                                           P=0.344N     |                                    P=0.094         | 
|POLY 6             |                                           P=0.381N     |                                    P=0.098         | 
|LOGISTIC REGRESSION|                                           P=0.379N     |                                    P=0.097         | 
|COCH-ARM / FISHERS |                                           P=0.312N     |                                    P=0.088         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)    |           1/50 (2%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  2/44.60                  3/42.09      |           1/45.04                  4/45.91         | 
|POLY-3 PERCENT (g) |                  4.5%                     7.1%         |           2.2%                     8.7%            | 
|TERMINAL (d)       |                  0/29 (0%)                2/31 (7%)    |           1/34 (3%)                4/36 (11%)      | 
|FIRST INCIDENCE    |                  710                      598          |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.498      |                                    P=0.196         | 
|POLY 3             |                                           P=0.479      |                                    P=0.183         | 
|POLY 1.5           |                                           P=0.487      |                                    P=0.183         | 
|POLY 6             |                                           P=0.472      |                                    P=0.184         | 
|LOGISTIC REGRESSION|                                           P=0.487      |                                    P=0.196         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.181         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  2/42.04      |           0/45.04                  1/46.16         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%         |           0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  ---                      647          |           ---                      670             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.214      |                                    P=0.514         | 
|POLY 3             |                                           P=0.231      |                                    P=0.500         | 
|POLY 1.5           |                                           P=0.233      |                                    P=0.500         | 
|POLY 6             |                                           P=0.229      |                                    P=0.500         | 
|LOGISTIC REGRESSION|                                           P=0.245      |                                    P=0.480         | 
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  30/50 (60%)              27/50 (54%)  |           20/50 (40%)              18/50 (36%)     | 
|POLY-3 RATE (b)    |                  30/49.18                 27/47.35     |           20/46.17                 18/46.75        | 
|POLY-3 PERCENT (g) |                  61.0%                    57.0%        |           43.3%                    38.5%           | 
|TERMINAL (d)       |                  14/29 (48%)              13/31 (42%)  |           13/34 (38%)              13/36 (36%)     | 
|FIRST INCIDENCE    |                  508                      499          |           660                      679             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.415N     |                                    P=0.361N        | 
|POLY 3             |                                           P=0.426N     |                                    P=0.396N        | 
|POLY 1.5           |                                           P=0.396N     |                                    P=0.398N        | 
|POLY 6             |                                           P=0.454N     |                                    P=0.397N        | 
|LOGISTIC REGRESSION|                                           P=0.242N     |                                    P=0.386N        | 
|COCH-ARM / FISHERS |                                           P=0.343N     |                                    P=0.418N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  8/50 (16%)               9/50 (18%)   |           3/50 (6%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  8/44.47                  9/42.82      |           3/45.37                  6/45.91         | 
|POLY-3 PERCENT (g) |                  18.0%                    21.0%        |           6.6%                     13.1%           | 
|TERMINAL (d)       |                  7/29 (24%)               7/31 (23%)   |           1/34 (3%)                6/36 (17%)      | 
|FIRST INCIDENCE    |                  724                      505          |           660                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.548      |                                    P=0.270         | 
|POLY 3             |                                           P=0.467      |                                    P=0.247         | 
|POLY 1.5           |                                           P=0.479      |                                    P=0.248         | 
|POLY 6             |                                           P=0.459      |                                    P=0.245         | 
|LOGISTIC REGRESSION|                                           P=0.436      |                                    P=0.254         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.243         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  29/50 (58%)              33/50 (66%)  |           15/50 (30%)              16/50 (32%)     | 
|POLY-3 RATE (b)    |                  29/48.19                 33/49.34     |           15/47.73                 16/48.78        | 
|POLY-3 PERCENT (g) |                  60.2%                    66.9%        |           31.4%                    32.8%           | 
|TERMINAL (d)       |                  15/29 (52%)              16/31 (52%)  |           4/34 (12%)               6/36 (17%)      | 
|FIRST INCIDENCE    |                  524                      429          |           576                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.309      |                                    P=0.541         | 
|POLY 3             |                                           P=0.315      |                                    P=0.528         | 
|POLY 1.5           |                                           P=0.295      |                                    P=0.524         | 
|POLY 6             |                                           P=0.342      |                                    P=0.529         | 
|LOGISTIC REGRESSION|                                           P=0.382      |                                    P=0.450         | 
|COCH-ARM / FISHERS |                                           P=0.268      |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  0/41.64      |           3/45.80                  2/46.09         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           6.6%                     4.3%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           0/34 (0%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           649                      690             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.488N        | 
|POLY 3             |                                           (e)          |                                    P=0.497N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.495N        | 
|POLY 6             |                                           (e)          |                                    P=0.500N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.524N        | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                2/50 (4%)    |           2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.88                  2/41.64      |           2/45.91                  3/46.28         | 
|POLY-3 PERCENT (g) |                  6.7%                     4.8%         |           4.4%                     6.5%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/31 (7%)    |           0/34 (0%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  631                      731 (T)      |           557                      632             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.495N     |                                    P=0.512         | 
|POLY 3             |                                           P=0.541N     |                                    P=0.503         | 
|POLY 1.5           |                                           P=0.525N     |                                    P=0.503         | 
|POLY 6             |                                           P=0.559N     |                                    P=0.502         | 
|LOGISTIC REGRESSION|                                           P=0.530N     |                                    P=0.446         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  6/50 (12%)               1/50 (2%)    |           2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  6/46.35                  1/42.30      |           2/46.33                  0/45.91         | 
|POLY-3 PERCENT (g) |                  12.9%                    2.4%         |           4.3%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  508                      508          |           203                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.081N     |                                    P=0.240N        | 
|POLY 3             |                                           P=0.075N     |                                    P=0.240N        | 
|POLY 1.5           |                                           P=0.067N     |                                    P=0.239N        | 
|POLY 6             |                                           P=0.084N     |                                    P=0.241N        | 
|LOGISTIC REGRESSION|                                           P=0.013N*    |                                    P=0.440N        | 
|COCH-ARM / FISHERS |                                           P=0.056N     |                                    P=0.247N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                3/50 (6%)    |           2/50 (4%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  4/44.88                  3/42.07      |           2/45.91                  5/46.45         | 
|POLY-3 PERCENT (g) |                  8.9%                     7.1%         |           4.4%                     10.8%           | 
|TERMINAL (d)       |                  2/29 (7%)                2/31 (7%)    |           0/34 (0%)                3/36 (8%)       | 
|FIRST INCIDENCE    |                  631                      606          |           557                      632             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.496N     |                                    P=0.236         | 
|POLY 3             |                                           P=0.541N     |                                    P=0.220         | 
|POLY 1.5           |                                           P=0.525N     |                                    P=0.221         | 
|POLY 6             |                                           P=0.556N     |                                    P=0.220         | 
|LOGISTIC REGRESSION|                                           P=0.515N     |                                    P=0.184         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.218         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                0/50 (0%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.11                  0/41.64      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  6.7%                     0.0%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  508                      ---          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.118N     |                                    (e)             | 
|POLY 3             |                                           P=0.139N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.131N     |                                    (e)             | 
|POLY 6             |                                           P=0.147N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.091N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.121N     |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           11/49 (22%)              11/50 (22%)     | 
|POLY-3 RATE (b)    |                                                        |           11/44.15                 11/45.91        | 
|POLY-3 PERCENT (g) |                                                        |           24.9%                    24.0%           | 
|TERMINAL (d)       |                                                        |           10/33 (30%)              11/36 (31%)     | 
|FIRST INCIDENCE    |                                                        |           708                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.509N        | 
|POLY 3             |                                                        |                                    P=0.554N        | 
|POLY 1.5           |                                                        |                                    P=0.556N        | 
|POLY 6             |                                                        |                                    P=0.550N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.520N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.574N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           13/49 (27%)              9/50 (18%)      | 
|POLY-3 RATE (b)    |                                                        |           13/44.76                 9/45.91         | 
|POLY-3 PERCENT (g) |                                                        |           29.0%                    19.6%           | 
|TERMINAL (d)       |                                                        |           11/33 (33%)              9/36 (25%)      | 
|FIRST INCIDENCE    |                                                        |           597                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.167N        | 
|POLY 3             |                                                        |                                    P=0.209N        | 
|POLY 1.5           |                                                        |                                    P=0.209N        | 
|POLY 6             |                                                        |                                    P=0.211N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.192N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.218N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           11/49 (22%)              16/50 (32%)     | 
|POLY-3 RATE (b)    |                                                        |           11/44.04                 16/45.91        | 
|POLY-3 PERCENT (g) |                                                        |           25.0%                    34.9%           | 
|TERMINAL (d)       |                                                        |           11/33 (33%)              16/36 (44%)     | 
|FIRST INCIDENCE    |                                                        |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.244         | 
|POLY 3             |                                                        |                                    P=0.211         | 
|POLY 1.5           |                                                        |                                    P=0.211         | 
|POLY 6             |                                                        |                                    P=0.213         | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.244         | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.200         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)    |                                                    | 
|POLY-3 RATE (b)    |                  3/44.93                  1/41.92      |                                                    | 
|POLY-3 PERCENT (g) |                  6.7%                     2.4%         |                                                    | 
|TERMINAL (d)       |                  1/29 (3%)                0/31 (0%)    |                                                    | 
|FIRST INCIDENCE    |                  659                      655          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.363N     |                                                    | 
|POLY 3             |                                           P=0.337N     |                                                    | 
|POLY 1.5           |                                           P=0.324N     |                                                    | 
|POLY 6             |                                           P=0.350N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.288N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.309N     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/2 (100%)               1/1 (100%)   |           1/1 (100%)               0/0 (0%)        | 
|POLY-3 RATE (b)    |                  2/2.00                   1/1.00       |           1/1.00                   0/0.00          | 
|POLY-3 PERCENT (g) |                  100.0%                   100.0%       |           100.0%                   0.0%            | 
|TERMINAL (d)       |                  2/2 (100%)               1/1 (100%)   |           1/1 (100%)               0/0 (0%)        | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           735 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    (e)             | 
|POLY 3             |                                           (e)          |                                    (e)             | 
|POLY 1.5           |                                           (e)          |                                    (e)             | 
|POLY 6             |                                           (e)          |                                    (e)             | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           (e)          |                                    (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  44/50 (88%)              46/50 (92%)  |           36/50 (72%)              45/50 (90%)     | 
|POLY-3 RATE (b)    |                  44/48.53                 46/50.00     |           36/46.67                 45/48.97        | 
|POLY-3 PERCENT (g) |                  90.7%                    92.0%        |           77.1%                    91.9%           | 
|TERMINAL (d)       |                  27/29 (93%)              27/31 (87%)  |           28/34 (82%)              35/36 (97%)     | 
|FIRST INCIDENCE    |                  508                      429          |           624                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.451      |                                    P=0.114         | 
|POLY 3             |                                           P=0.549      |                                    P=0.031 *       | 
|POLY 1.5           |                                           P=0.465      |                                    P=0.028 *       | 
|POLY 6             |                                           P=0.628N     |                                    P=0.033 *       | 
|LOGISTIC REGRESSION|                                           P=0.367      |                                    P=0.022 *       | 
|COCH-ARM / FISHERS |                                           P=0.370      |                                    P=0.020 *       | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  3/42.74      |           1/45.09                  0/45.91         | 
|POLY-3 PERCENT (g) |                  2.3%                     7.0%         |           2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  731 (T)                  429          |           723                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.306      |                                    P=0.495N        | 
|POLY 3             |                                           P=0.295      |                                    P=0.493N        | 
|POLY 1.5           |                                           P=0.299      |                                    P=0.494N        | 
|POLY 6             |                                           P=0.291      |                                    P=0.492N        | 
|LOGISTIC REGRESSION|                                           P=0.396      |                                    P=0.495N        | 
|COCH-ARM / FISHERS |                                           P=0.309      |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                4/50 (8%)    |           1/50 (2%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  3/45.01                  4/42.07      |           1/45.30                  5/45.91         | 
|POLY-3 PERCENT (g) |                  6.7%                     9.5%         |           2.2%                     10.9%           | 
|TERMINAL (d)       |                  1/29 (3%)                3/31 (10%)   |           0/34 (0%)                5/36 (14%)      | 
|FIRST INCIDENCE    |                  586                      606          |           666                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.497      |                                    P=0.118         | 
|POLY 3             |                                           P=0.469      |                                    P=0.104         | 
|POLY 1.5           |                                           P=0.481      |                                    P=0.104         | 
|POLY 6             |                                           P=0.457      |                                    P=0.103         | 
|LOGISTIC REGRESSION|                                           P=0.499      |                                    P=0.108         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.102         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  10/50 (20%)              4/50 (8%)    |           0/50 (0%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  10/44.74                 4/42.07      |           0/45.04                  4/46.07         | 
|POLY-3 PERCENT (g) |                  22.4%                    9.5%         |           0.0%                     8.7%            | 
|TERMINAL (d)       |                  8/29 (28%)               3/31 (10%)   |           0/34 (0%)                3/36 (8%)       | 
|FIRST INCIDENCE    |                  676                      606          |           ---                      695             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.068N     |                                    P=0.071         | 
|POLY 3             |                                           P=0.090N     |                                    P=0.062         | 
|POLY 1.5           |                                           P=0.084N     |                                    P=0.062         | 
|POLY 6             |                                           P=0.097N     |                                    P=0.063         | 
|LOGISTIC REGRESSION|                                           P=0.100N     |                                    P=0.066         | 
|COCH-ARM / FISHERS |                                           P=0.074N     |                                    P=0.059         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  38/50 (76%)              31/50 (62%)  |           30/50 (60%)              38/50 (76%)     | 
|POLY-3 RATE (b)    |                  38/46.97                 31/46.41     |           30/47.37                 38/48.65        | 
|POLY-3 PERCENT (g) |                  80.9%                    66.8%        |           63.3%                    78.1%           | 
|TERMINAL (d)       |                  26/29 (90%)              20/31 (65%)  |           19/34 (56%)              29/36 (81%)     | 
|FIRST INCIDENCE    |                  508                      499          |           557                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.129N     |                                    P=0.181         | 
|POLY 3             |                                           P=0.082N     |                                    P=0.079         | 
|POLY 1.5           |                                           P=0.091N     |                                    P=0.079         | 
|POLY 6             |                                           P=0.065N     |                                    P=0.075         | 
|LOGISTIC REGRESSION|                                           P=0.158N     |                                    P=0.077         | 
|COCH-ARM / FISHERS |                                           P=0.097N     |                                    P=0.066         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  47/50 (94%)              47/50 (94%)  |           39/50 (78%)              43/50 (86%)     | 
|POLY-3 RATE (b)    |                  47/48.44                 47/48.89     |           39/46.76                 43/49.75        | 
|POLY-3 PERCENT (g) |                  97.0%                    96.1%        |           83.4%                    86.4%           | 
|TERMINAL (d)       |                  29/29 (100%)             31/31 (100%) |           31/34 (91%)              31/36 (86%)     | 
|FIRST INCIDENCE    |                  524                      429          |           576                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.534N     |                                    P=0.424         | 
|POLY 3             |                                           P=0.657N     |                                    P=0.443         | 
|POLY 1.5           |                                           P=0.650N     |                                    P=0.353         | 
|POLY 6             |                                           P=0.738N     |                                    P=0.574         | 
|LOGISTIC REGRESSION|                                           P=0.437      |                                    P=0.261         | 
|COCH-ARM / FISHERS |                                           P=0.661N     |                                    P=0.218         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  25/50 (50%)              26/50 (52%)  |           42/50 (84%)              44/50 (88%)     | 
|POLY-3 RATE (b)    |                  25/45.49                 26/43.54     |           42/47.35                 44/48.51        | 
|POLY-3 PERCENT (g) |                  55.0%                    59.7%        |           88.7%                    90.7%           | 
|TERMINAL (d)       |                  21/29 (72%)              21/31 (68%)  |           32/34 (94%)              34/36 (94%)     | 
|FIRST INCIDENCE    |                  508                      577          |           557                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.575N     |                                    P=0.571N        | 
|POLY 3             |                                           P=0.404      |                                    P=0.504         | 
|POLY 1.5           |                                           P=0.439      |                                    P=0.469         | 
|POLY 6             |                                           P=0.380      |                                    P=0.569         | 
|LOGISTIC REGRESSION|                                           P=0.304      |                                    P=0.450         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.387         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)    |           1/50 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  1/41.64      |           1/45.04                  2/45.91         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.4%         |           2.2%                     4.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           1/34 (3%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.747N     |                                    P=0.520         | 
|POLY 3             |                                           P=0.754      |                                    P=0.504         | 
|POLY 1.5           |                                           P=0.756      |                                    P=0.504         | 
|POLY 6             |                                           P=0.752      |                                    P=0.506         | 
|LOGISTIC REGRESSION|                                           P=0.747N     |                                    P=0.520         | 
|COCH-ARM / FISHERS |                                           P=0.753N     |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/44.44                  1/42.07      |           0/45.04                  1/45.91         | 
|POLY-3 PERCENT (g) |                  4.5%                     2.4%         |           0.0%                     2.2%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/31 (0%)    |           0/34 (0%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  731 (T)                  606          |           ---                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.493N     |                                    P=0.511         | 
|POLY 3             |                                           P=0.526N     |                                    P=0.500         | 
|POLY 1.5           |                                           P=0.516N     |                                    P=0.500         | 
|POLY 6             |                                           P=0.534N     |                                    P=0.500         | 
|LOGISTIC REGRESSION|                                           P=0.501N     |                                    P=0.511         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)    |           3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  1/41.64      |           3/46.07                  2/45.91         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.4%         |           6.5%                     4.4%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           0/34 (0%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           576                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.747N     |                                    P=0.485N        | 
|POLY 3             |                                           P=0.754      |                                    P=0.502N        | 
|POLY 1.5           |                                           P=0.756      |                                    P=0.498N        | 
|POLY 6             |                                           P=0.752      |                                    P=0.507N        | 
|LOGISTIC REGRESSION|                                           P=0.747N     |                                    P=0.539N        | 
|COCH-ARM / FISHERS |                                           P=0.753N     |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           4/50 (8%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  2/44.44                  2/41.64      |           4/45.04                  5/46.41         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.8%         |           8.9%                     10.8%           | 
|TERMINAL (d)       |                  2/29 (7%)                2/31 (7%)    |           4/34 (12%)               3/36 (8%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           735 (T)                  632             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.672N     |                                    P=0.529         | 
|POLY 3             |                                           P=0.677      |                                    P=0.517         | 
|POLY 1.5           |                                           P=0.683      |                                    P=0.512         | 
|POLY 6             |                                           P=0.671      |                                    P=0.524         | 
|LOGISTIC REGRESSION|                                           P=0.672N     |                                    P=0.512         | 
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  33/50 (66%)              38/50 (76%)  |           44/50 (88%)              41/50 (82%)     | 
|POLY-3 RATE (b)    |                  33/46.73                 38/45.03     |           44/48.18                 41/47.63        | 
|POLY-3 PERCENT (g) |                  70.6%                    84.4%        |           91.3%                    86.1%           | 
|TERMINAL (d)       |                  24/29 (83%)              30/31 (97%)  |           32/34 (94%)              34/36 (94%)     | 
|FIRST INCIDENCE    |                  508                      499          |           557                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.274      |                                    P=0.197N        | 
|POLY 3             |                                           P=0.074      |                                    P=0.301N        | 
|POLY 1.5           |                                           P=0.114      |                                    P=0.268N        | 
|POLY 6             |                                           P=0.041 *    |                                    P=0.359N        | 
|LOGISTIC REGRESSION|                                           P=0.051      |                                    P=0.206N        | 
|COCH-ARM / FISHERS |                                           P=0.189      |                                    P=0.288N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  18/50 (36%)              29/50 (58%)  |           26/50 (52%)              25/50 (50%)     | 
|POLY-3 RATE (b)    |                  18/44.52                 29/42.61     |           26/46.17                 25/46.88        | 
|POLY-3 PERCENT (g) |                  40.4%                    68.1%        |           56.3%                    53.3%           | 
|TERMINAL (d)       |                  17/29 (59%)              26/31 (84%)  |           23/34 (68%)              21/36 (58%)     | 
|FIRST INCIDENCE    |                  711                      577          |           557                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.017 *    |                                    P=0.392N        | 
|POLY 3             |                                           P=0.005 **   |                                    P=0.467N        | 
|POLY 1.5           |                                           P=0.010 *    |                                    P=0.473N        | 
|POLY 6             |                                           P=0.003 **   |                                    P=0.449N        | 
|LOGISTIC REGRESSION|                                           P=0.002 **   |                                    P=0.456N        | 
|COCH-ARM / FISHERS |                                           P=0.022 *    |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                5/50 (10%)   |           5/50 (10%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/44.52                  5/43.41      |           5/45.67                  3/46.16         | 
|POLY-3 PERCENT (g) |                  4.5%                     11.5%        |           11.0%                    6.5%            | 
|TERMINAL (d)       |                  1/29 (3%)                2/31 (7%)    |           2/34 (6%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  711                      429          |           652                      670             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.222      |                                    P=0.335N        | 
|POLY 3             |                                           P=0.207      |                                    P=0.350N        | 
|POLY 1.5           |                                           P=0.211      |                                    P=0.350N        | 
|POLY 6             |                                           P=0.203      |                                    P=0.351N        | 
|LOGISTIC REGRESSION|                                           P=0.305      |                                    P=0.357N        | 
|COCH-ARM / FISHERS |                                           P=0.218      |                                    P=0.357N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  45/50 (90%)              46/50 (92%)  |           21/50 (42%)              25/50 (50%)     | 
|POLY-3 RATE (b)    |                  45/47.68                 46/48.14     |           21/46.11                 25/47.53        | 
|POLY-3 PERCENT (g) |                  94.4%                    95.6%        |           45.5%                    52.6%           | 
|TERMINAL (d)       |                  29/29 (100%)             31/31 (100%) |           16/34 (47%)              19/36 (53%)     | 
|FIRST INCIDENCE    |                  508                      429          |           597                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.546      |                                    P=0.365         | 
|POLY 3             |                                           P=0.603      |                                    P=0.315         | 
|POLY 1.5           |                                           P=0.543      |                                    P=0.304         | 
|POLY 6             |                                           P=0.763      |                                    P=0.332         | 
|LOGISTIC REGRESSION|                                           P=0.196      |                                    P=0.299         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.274         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                7/50 (14%)   |           1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  4/44.68                  7/41.73      |           1/45.61                  1/46.31         | 
|POLY-3 PERCENT (g) |                  9.0%                     16.8%        |           2.2%                     2.2%            | 
|TERMINAL (d)       |                  2/29 (7%)                6/31 (19%)   |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  690                      707          |           557                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.275      |                                    P=0.760N        | 
|POLY 3             |                                           P=0.225      |                                    P=0.755N        | 
|POLY 1.5           |                                           P=0.239      |                                    P=0.756N        | 
|POLY 6             |                                           P=0.211      |                                    P=0.754N        | 
|LOGISTIC REGRESSION|                                           P=0.208      |                                    P=0.691         | 
|COCH-ARM / FISHERS |                                           P=0.262      |                                    P=0.753N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  23/50 (46%)              37/50 (74%)  |           31/50 (62%)              32/50 (64%)     | 
|POLY-3 RATE (b)    |                  23/47.84                 37/45.78     |           31/47.03                 32/47.61        | 
|POLY-3 PERCENT (g) |                  48.1%                    80.8%        |           65.9%                    67.2%           | 
|TERMINAL (d)       |                  13/29 (45%)              26/31 (84%)  |           24/34 (71%)              26/36 (72%)     | 
|FIRST INCIDENCE    |                  508                      505          |           557                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.015 *    |                                    P=0.528N        | 
|POLY 3             |                                           P<0.001 **   |                                    P=0.533         | 
|POLY 1.5           |                                           P<0.001 **   |                                    P=0.534         | 
|POLY 6             |                                           P<0.001 **   |                                    P=0.525         | 
|LOGISTIC REGRESSION|                                           P=0.003 **   |                                    P=0.546         | 
|COCH-ARM / FISHERS |                                           P=0.004 **   |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  26/50 (52%)              32/50 (64%)  |           31/50 (62%)              36/50 (72%)     | 
|POLY-3 RATE (b)    |                  26/45.30                 32/44.20     |           31/47.41                 36/46.90        | 
|POLY-3 PERCENT (g) |                  57.4%                    72.4%        |           65.4%                    76.8%           | 
|TERMINAL (d)       |                  21/29 (72%)              27/31 (87%)  |           24/34 (71%)              32/36 (89%)     | 
|FIRST INCIDENCE    |                  603                      499          |           557                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.200      |                                    P=0.312         | 
|POLY 3             |                                           P=0.090      |                                    P=0.152         | 
|POLY 1.5           |                                           P=0.113      |                                    P=0.180         | 
|POLY 6             |                                           P=0.069      |                                    P=0.117         | 
|LOGISTIC REGRESSION|                                           P=0.041 *    |                                    P=0.224         | 
|COCH-ARM / FISHERS |                                           P=0.156      |                                    P=0.198         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  45/50 (90%)              46/50 (92%)  |           45/50 (90%)              45/50 (90%)     | 
|POLY-3 RATE (b)    |                  45/48.99                 46/48.78     |           45/49.02                 45/49.83        | 
|POLY-3 PERCENT (g) |                  91.9%                    94.3%        |           91.8%                    90.3%           | 
|TERMINAL (d)       |                  27/29 (93%)              30/31 (97%)  |           30/34 (88%)              32/36 (89%)     | 
|FIRST INCIDENCE    |                  508                      429          |           557                      523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.522      |                                    P=0.426N        | 
|POLY 3             |                                           P=0.466      |                                    P=0.536N        | 
|POLY 1.5           |                                           P=0.483      |                                    P=0.541N        | 
|POLY 6             |                                           P=0.435      |                                    P=0.552N        | 
|LOGISTIC REGRESSION|                                           P=0.416      |                                    P=0.588N        | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.630N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  30/50 (60%)              35/50 (70%)  |           44/50 (88%)              47/50 (94%)     | 
|POLY-3 RATE (b)    |                  30/46.22                 35/44.21     |           44/47.96                 47/49.18        | 
|POLY-3 PERCENT (g) |                  64.9%                    79.2%        |           91.7%                    95.6%           | 
|TERMINAL (d)       |                  22/29 (76%)              29/31 (94%)  |           33/34 (97%)              36/36 (100%)    | 
|FIRST INCIDENCE    |                  583                      505          |           557                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.264      |                                    P=0.520         | 
|POLY 3             |                                           P=0.086      |                                    P=0.347         | 
|POLY 1.5           |                                           P=0.128      |                                    P=0.319         | 
|POLY 6             |                                           P=0.047 *    |                                    P=0.398         | 
|LOGISTIC REGRESSION|                                           P=0.051      |                                    P=0.303         | 
|COCH-ARM / FISHERS |                                           P=0.201      |                                    P=0.243         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  9/50 (18%)               10/50 (20%)  |           12/50 (24%)              12/50 (24%)     | 
|POLY-3 RATE (b)    |                  9/44.98                  10/42.66     |           12/45.51                 12/45.91        | 
|POLY-3 PERCENT (g) |                  20.0%                    23.4%        |           26.4%                    26.1%           | 
|TERMINAL (d)       |                  7/29 (24%)               8/31 (26%)   |           11/34 (32%)              12/36 (33%)     | 
|FIRST INCIDENCE    |                  598                      577          |           597                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.534      |                                    P=0.532N        | 
|POLY 3             |                                           P=0.451      |                                    P=0.584N        | 
|POLY 1.5           |                                           P=0.470      |                                    P=0.581N        | 
|POLY 6             |                                           P=0.434      |                                    P=0.587N        | 
|LOGISTIC REGRESSION|                                           P=0.436      |                                    P=0.560N        | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.592N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  31/50 (62%)              36/50 (72%)  |           44/50 (88%)              47/50 (94%)     | 
|POLY-3 RATE (b)    |                  31/46.70                 36/44.90     |           44/47.96                 47/49.18        | 
|POLY-3 PERCENT (g) |                  66.4%                    80.2%        |           91.7%                    95.6%           | 
|TERMINAL (d)       |                  22/29 (76%)              29/31 (94%)  |           33/34 (97%)              36/36 (100%)    | 
|FIRST INCIDENCE    |                  583                      499          |           557                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.268      |                                    P=0.520         | 
|POLY 3             |                                           P=0.090      |                                    P=0.347         | 
|POLY 1.5           |                                           P=0.130      |                                    P=0.319         | 
|POLY 6             |                                           P=0.050      |                                    P=0.398         | 
|LOGISTIC REGRESSION|                                           P=0.071      |                                    P=0.303         | 
|COCH-ARM / FISHERS |                                           P=0.198      |                                    P=0.243         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/24 (8%)                0/20 (0%)    |           0/30 (0%)                0/25 (0%)       | 
|POLY-3 RATE (b)    |                  2/22.15                  0/16.32      |           0/28.35                  0/23.04         | 
|POLY-3 PERCENT (g) |                  9.0%                     0.0%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/13 (8%)                0/11 (0%)    |           0/21 (0%)                0/19 (0%)       | 
|FIRST INCIDENCE    |                  711                      ---          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.254N     |                                    (e)             | 
|POLY 3             |                                           P=0.352N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.329N     |                                    (e)             | 
|POLY 6             |                                           P=0.379N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.320N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.292N     |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/2 (100%)               0/0 (0%)     |           1/1 (100%)               0/2 (0%)        | 
|POLY-3 RATE (b)    |                  2/2.00                   0/0.00       |           1/1.00                   0/2.00          | 
|POLY-3 PERCENT (g) |                  100.0%                   0.0%         |           100.0%                   0.0%            | 
|TERMINAL (d)       |                  2/2 (100%)               0/0 (0%)     |           1/1 (100%)               0/2 (0%)        | 
|FIRST INCIDENCE    |                  731 (T)                  ---          |           735 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.362N        | 
|POLY 3             |                                           (e)          |                                    P=1.000         | 
|POLY 1.5           |                                           (e)          |                                    P=1.000         | 
|POLY 6             |                                           (e)          |                                    P=1.000         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.333N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  6/50 (12%)               10/50 (20%)  |           15/50 (30%)              17/50 (34%)     | 
|POLY-3 RATE (b)    |                  6/44.44                  10/43.05     |           15/45.47                 17/46.09        | 
|POLY-3 PERCENT (g) |                  13.5%                    23.2%        |           33.0%                    36.9%           | 
|TERMINAL (d)       |                  6/29 (21%)               7/31 (23%)   |           13/34 (38%)              16/36 (44%)     | 
|FIRST INCIDENCE    |                  731 (T)                  499          |           652                      690             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.228      |                                    P=0.487         | 
|POLY 3             |                                           P=0.184      |                                    P=0.431         | 
|POLY 1.5           |                                           P=0.192      |                                    P=0.431         | 
|POLY 6             |                                           P=0.180      |                                    P=0.429         | 
|LOGISTIC REGRESSION|                                           P=0.172      |                                    P=0.457         | 
|COCH-ARM / FISHERS |                                           P=0.207      |                                    P=0.415         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  7/50 (14%)               10/50 (20%)  |           19/50 (38%)              20/50 (40%)     | 
|POLY-3 RATE (b)    |                  7/44.66                  10/42.91     |           19/45.52                 20/46.39        | 
|POLY-3 PERCENT (g) |                  15.7%                    23.3%        |           41.7%                    43.1%           | 
|TERMINAL (d)       |                  6/29 (21%)               7/31 (23%)   |           16/34 (47%)              18/36 (50%)     | 
|FIRST INCIDENCE    |                  673                      499          |           652                      652             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.311      |                                    P=0.581N        | 
|POLY 3             |                                           P=0.265      |                                    P=0.530         | 
|POLY 1.5           |                                           P=0.277      |                                    P=0.525         | 
|POLY 6             |                                           P=0.256      |                                    P=0.537         | 
|LOGISTIC REGRESSION|                                           P=0.251      |                                    P=0.549         | 
|COCH-ARM / FISHERS |                                           P=0.298      |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/44.44                  0/41.64      |           2/45.20                  1/46.04         | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%         |           4.4%                     2.2%            | 
|TERMINAL (d)       |                  2/29 (7%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  731 (T)                  ---          |           708                      702             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.223N     |                                    P=0.497N        | 
|POLY 3             |                                           P=0.260N     |                                    P=0.491N        | 
|POLY 1.5           |                                           P=0.251N     |                                    P=0.493N        | 
|POLY 6             |                                           P=0.268N     |                                    P=0.490N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.497N        | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/24 (13%)               0/20 (0%)    |           1/30 (3%)                0/25 (0%)       | 
|POLY-3 RATE (b)    |                  3/22.40                  0/16.32      |           1/28.46                  0/23.04         | 
|POLY-3 PERCENT (g) |                  13.4%                    0.0%         |           3.5%                     0.0%            | 
|TERMINAL (d)       |                  0/13 (0%)                0/11 (0%)    |           0/21 (0%)                0/19 (0%)       | 
|FIRST INCIDENCE    |                  690                      ---          |           708                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.137N     |                                    P=0.500N        | 
|POLY 3             |                                           P=0.207N     |                                    P=0.585N        | 
|POLY 1.5           |                                           P=0.186N     |                                    P=0.580N        | 
|POLY 6             |                                           P=0.234N     |                                    P=0.589N        | 
|LOGISTIC REGRESSION|                                           P=0.162N     |                                    P=0.526N        | 
|COCH-ARM / FISHERS |                                           P=0.153N     |                                    P=0.545N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/24 (13%)               1/20 (5%)    |           0/30 (0%)                0/25 (0%)       | 
|POLY-3 RATE (b)    |                  3/22.53                  1/16.32      |           0/28.35                  0/23.04         | 
|POLY-3 PERCENT (g) |                  13.3%                    6.1%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/13 (0%)                1/11 (9%)    |           0/21 (0%)                0/19 (0%)       | 
|FIRST INCIDENCE    |                  659                      731 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.352N     |                                    (e)             | 
|POLY 3             |                                           P=0.464N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.431N     |                                    (e)             | 
|POLY 6             |                                           P=0.505N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.393N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.376N     |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)    |           5/50 (10%)               4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  0/41.64      |           5/45.39                  4/46.28         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%         |           11.0%                    8.6%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/31 (0%)    |           3/34 (9%)                3/36 (8%)       | 
|FIRST INCIDENCE    |                  731 (T)                  ---          |           652                      632             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.487N     |                                    P=0.472N        | 
|POLY 3             |                                           P=0.527N     |                                    P=0.487N        | 
|POLY 1.5           |                                           P=0.516N     |                                    P=0.489N        | 
|POLY 6             |                                           P=0.537N     |                                    P=0.484N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.493N        | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  45/50 (90%)              47/50 (94%)  |           43/50 (86%)              47/50 (94%)     | 
|POLY-3 RATE (b)    |                  45/49.48                 47/49.57     |           43/48.02                 47/49.06        | 
|POLY-3 PERCENT (g) |                  90.9%                    94.8%        |           89.6%                    95.8%           | 
|TERMINAL (d)       |                  26/29 (90%)              29/31 (94%)  |           31/34 (91%)              35/36 (97%)     | 
|FIRST INCIDENCE    |                  508                      429          |           557                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.442      |                                    P=0.440         | 
|POLY 3             |                                           P=0.355      |                                    P=0.195         | 
|POLY 1.5           |                                           P=0.355      |                                    P=0.194         | 
|POLY 6             |                                           P=0.360      |                                    P=0.197         | 
|LOGISTIC REGRESSION|                                           P=0.373      |                                    P=0.197         | 
|COCH-ARM / FISHERS |                                           P=0.357      |                                    P=0.159         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  11/14 (79%)              2/5 (40%)    |           4/11 (36%)               8/9 (89%)       | 
|POLY-3 RATE (b)    |                  11/12.88                 2/4.43       |           4/10.05                  8/8.83          | 
|POLY-3 PERCENT (g) |                  85.4%                    45.1%        |           39.8%                    90.6%           | 
|TERMINAL (d)       |                  7/8 (88%)                2/3 (67%)    |           3/7 (43%)                6/6 (100%)      | 
|FIRST INCIDENCE    |                  676                      731 (T)      |           666                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.053N     |                                    P=0.068         | 
|POLY 3             |                                           P=0.207N     |                                    P=0.019 *       | 
|POLY 1.5           |                                           P=0.202N     |                                    P=0.018 *       | 
|POLY 6             |                                           P=0.265N     |                                    P=0.021 *       | 
|LOGISTIC REGRESSION|                                           P=0.140N     |                                    P=0.028 *       | 
|COCH-ARM / FISHERS |                                           P=0.151N     |                                    P=0.025 *       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  8/14 (57%)               2/5 (40%)    |           8/11 (73%)               5/9 (56%)       | 
|POLY-3 RATE (b)    |                  8/12.79                  2/4.43       |           8/10.62                  5/8.36          | 
|POLY-3 PERCENT (g) |                  62.6%                    45.1%        |           75.4%                    59.8%           | 
|TERMINAL (d)       |                  5/8 (63%)                2/3 (67%)    |           6/7 (86%)                4/6 (67%)       | 
|FIRST INCIDENCE    |                  676                      731 (T)      |           576                      690             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.231N     |                                    P=0.294N        | 
|POLY 3             |                                           P=0.579N     |                                    P=0.434N        | 
|POLY 1.5           |                                           P=0.555N     |                                    P=0.416N        | 
|POLY 6             |                                           P=0.639N     |                                    P=0.458N        | 
|LOGISTIC REGRESSION|                                           P=0.483N     |                                    P=0.348N        | 
|COCH-ARM / FISHERS |                                           P=0.444N     |                                    P=0.370N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  11/14 (79%)              2/5 (40%)    |           9/11 (82%)               7/9 (78%)       | 
|POLY-3 RATE (b)    |                  11/12.88                 2/4.43       |           9/11.00                  7/8.83          | 
|POLY-3 PERCENT (g) |                  85.4%                    45.1%        |           81.8%                    79.3%           | 
|TERMINAL (d)       |                  7/8 (88%)                2/3 (67%)    |           5/7 (71%)                5/6 (83%)       | 
|FIRST INCIDENCE    |                  676                      731 (T)      |           576                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.053N     |                                    P=0.458N        | 
|POLY 3             |                                           P=0.207N     |                                    P=0.683N        | 
|POLY 1.5           |                                           P=0.202N     |                                    P=0.665N        | 
|POLY 6             |                                           P=0.265N     |                                    P=0.715N        | 
|LOGISTIC REGRESSION|                                           P=0.140N     |                                    P=0.652N        | 
|COCH-ARM / FISHERS |                                           P=0.151N     |                                    P=0.625N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  2/42.52      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.7%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  ---                      598          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.222      |                                    (e)             | 
|POLY 3             |                                           P=0.232      |                                    (e)             | 
|POLY 1.5           |                                           P=0.234      |                                    (e)             | 
|POLY 6             |                                           P=0.231      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.330      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.247      |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)    |           4/50 (8%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.07                  4/42.86      |           4/45.43                  1/46.16         | 
|POLY-3 PERCENT (g) |                  4.4%                     9.3%         |           8.8%                     2.2%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/31 (3%)    |           2/34 (6%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  615                      598          |           666                      670             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.299      |                                    P=0.171N        | 
|POLY 3             |                                           P=0.318      |                                    P=0.173N        | 
|POLY 1.5           |                                           P=0.325      |                                    P=0.174N        | 
|POLY 6             |                                           P=0.312      |                                    P=0.172N        | 
|LOGISTIC REGRESSION|                                           P=0.434      |                                    P=0.181N        | 
|COCH-ARM / FISHERS |                                           P=0.339      |                                    P=0.181N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  1/44.55                  2/42.43      |           2/45.71                  3/47.16         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.7%         |           4.4%                     6.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  703                      577          |           624                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.458      |                                    P=0.510         | 
|POLY 3             |                                           P=0.489      |                                    P=0.511         | 
|POLY 1.5           |                                           P=0.493      |                                    P=0.508         | 
|POLY 6             |                                           P=0.486      |                                    P=0.515         | 
|LOGISTIC REGRESSION|                                           P=0.574      |                                    P=0.389         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  12/50 (24%)              6/50 (12%)   |           4/50 (8%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  12/47.10                 6/42.35      |           4/45.04                  5/46.55         | 
|POLY-3 PERCENT (g) |                  25.5%                    14.2%        |           8.9%                     10.7%           | 
|TERMINAL (d)       |                  5/29 (17%)               3/31 (10%)   |           4/34 (12%)               4/36 (11%)      | 
|FIRST INCIDENCE    |                  508                      637          |           735 (T)                  523             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.130N     |                                    P=0.533         | 
|POLY 3             |                                           P=0.145N     |                                    P=0.518         | 
|POLY 1.5           |                                           P=0.124N     |                                    P=0.513         | 
|POLY 6             |                                           P=0.171N     |                                    P=0.524         | 
|LOGISTIC REGRESSION|                                           P=0.072N     |                                    P=0.506         | 
|COCH-ARM / FISHERS |                                           P=0.096N     |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  13/13 (100%)             12/13 (92%)  |           11/12 (92%)              9/11 (82%)      | 
|POLY-3 RATE (b)    |                  13/13.00                 12/13.00     |           11/12.00                 9/11.00         | 
|POLY-3 PERCENT (g) |                  100.0%                   92.3%        |           91.7%                    81.8%           | 
|TERMINAL (d)       |                  9/9 (100%)               10/11 (91%)  |           8/9 (89%)                8/10 (80%)      | 
|FIRST INCIDENCE    |                  696                      429          |           597                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.257N     |                                    P=0.234N        | 
|POLY 3             |                                           P=0.500N     |                                    P=0.479N        | 
|POLY 1.5           |                                           P=0.500N     |                                    P=0.479N        | 
|POLY 6             |                                           P=0.500N     |                                    P=0.479N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.466N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  9/13 (69%)               4/13 (31%)   |           5/12 (42%)               8/11 (73%)      | 
|POLY-3 RATE (b)    |                  9/12.86                  4/11.90      |           5/12.00                  8/11.00         | 
|POLY-3 PERCENT (g) |                  70.0%                    33.6%        |           41.7%                    72.7%           | 
|TERMINAL (d)       |                  6/9 (67%)                4/11 (36%)   |           2/9 (22%)                7/10 (70%)      | 
|FIRST INCIDENCE    |                  709                      731 (T)      |           597                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.040N*    |                                    P=0.308         | 
|POLY 3             |                                           P=0.074N     |                                    P=0.143         | 
|POLY 1.5           |                                           P=0.065N     |                                    P=0.143         | 
|POLY 6             |                                           P=0.083N     |                                    P=0.143         | 
|LOGISTIC REGRESSION|                                           P=0.076N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.058N     |                                    P=0.140         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           9/50 (18%)               5/50 (10%)      | 
|POLY-3 RATE (b)    |                                                        |           9/45.82                  5/46.05         | 
|POLY-3 PERCENT (g) |                                                        |           19.6%                    10.9%           | 
|TERMINAL (d)       |                                                        |           7/34 (21%)               3/36 (8%)       | 
|FIRST INCIDENCE    |                                                        |           576                      702             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.173N        | 
|POLY 3             |                                                        |                                    P=0.189N        | 
|POLY 1.5           |                                                        |                                    P=0.188N        | 
|POLY 6             |                                                        |                                    P=0.190N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.185N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.194N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  13/50 (26%)              25/50 (50%)  |           12/50 (24%)              14/50 (28%)     | 
|POLY-3 RATE (b)    |                  13/45.13                 25/45.12     |           12/45.39                 14/46.46        | 
|POLY-3 PERCENT (g) |                  28.8%                    55.4%        |           26.4%                    30.1%           | 
|TERMINAL (d)       |                  9/29 (31%)               16/31 (52%)  |           10/34 (29%)              12/36 (33%)     | 
|FIRST INCIDENCE    |                  603                      499          |           690                      652             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.023 *    |                                    P=0.473         | 
|POLY 3             |                                           P=0.007 **   |                                    P=0.435         | 
|POLY 1.5           |                                           P=0.008 **   |                                    P=0.430         | 
|POLY 6             |                                           P=0.007 **   |                                    P=0.442         | 
|LOGISTIC REGRESSION|                                           P=0.007 **   |                                    P=0.438         | 
|COCH-ARM / FISHERS |                                           P=0.011 *    |                                    P=0.410         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)    |           0/50 (0%)                8/50 (16%)      | 
|POLY-3 RATE (b)    |                  2/44.47                  3/42.07      |           0/45.04                  8/46.61         | 
|POLY-3 PERCENT (g) |                  4.5%                     7.1%         |           0.0%                     17.2%           | 
|TERMINAL (d)       |                  1/29 (3%)                2/31 (7%)    |           0/34 (0%)                6/36 (17%)      | 
|FIRST INCIDENCE    |                  724                      606          |           ---                      620             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.517      |                                    P=0.007 **      | 
|POLY 3             |                                           P=0.480      |                                    P=0.004 **      | 
|POLY 1.5           |                                           P=0.487      |                                    P=0.004 **      | 
|POLY 6             |                                           P=0.474      |                                    P=0.004 **      | 
|LOGISTIC REGRESSION|                                           P=0.473      |                                    P=0.005 **      | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.003 **      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)    |           2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  1/42.09      |           2/45.63                  2/45.91         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.4%         |           4.4%                     4.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           0/34 (0%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  ---                      598          |           597                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.482      |                                    P=0.680N        | 
|POLY 3             |                                           P=0.501      |                                    P=0.691N        | 
|POLY 1.5           |                                           P=0.500      |                                    P=0.690N        | 
|POLY 6             |                                           P=0.501      |                                    P=0.694N        | 
|LOGISTIC REGRESSION|                                           P=0.599      |                                    P=0.685         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.691N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)    |           30/50 (60%)              27/50 (54%)     | 
|POLY-3 RATE (b)    |                  2/44.52                  4/42.82      |           30/47.80                 27/48.21        | 
|POLY-3 PERCENT (g) |                  4.5%                     9.3%         |           62.8%                    56.0%           | 
|TERMINAL (d)       |                  1/29 (3%)                2/31 (7%)    |           20/34 (59%)              19/36 (53%)     | 
|FIRST INCIDENCE    |                  710                      505          |           203                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.343      |                                    P=0.290N        | 
|POLY 3             |                                           P=0.322      |                                    P=0.319N        | 
|POLY 1.5           |                                           P=0.328      |                                    P=0.331N        | 
|POLY 6             |                                           P=0.317      |                                    P=0.301N        | 
|LOGISTIC REGRESSION|                                           P=0.385      |                                    P=0.347N        | 
|COCH-ARM / FISHERS |                                           P=0.339      |                                    P=0.343N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  16/50 (32%)              13/50 (26%)  |           24/50 (48%)              19/50 (38%)     | 
|POLY-3 RATE (b)    |                  16/46.00                 13/43.99     |           24/46.05                 19/46.53        | 
|POLY-3 PERCENT (g) |                  34.8%                    29.6%        |           52.1%                    40.8%           | 
|TERMINAL (d)       |                  9/29 (31%)               8/31 (26%)   |           20/34 (59%)              17/36 (47%)     | 
|FIRST INCIDENCE    |                  583                      499          |           597                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.350N     |                                    P=0.145N        | 
|POLY 3             |                                           P=0.382N     |                                    P=0.186N        | 
|POLY 1.5           |                                           P=0.361N     |                                    P=0.189N        | 
|POLY 6             |                                           P=0.404N     |                                    P=0.183N        | 
|LOGISTIC REGRESSION|                                           P=0.336N     |                                    P=0.174N        | 
|COCH-ARM / FISHERS |                                           P=0.330N     |                                    P=0.210N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.44                  2/41.64      |           2/45.51                  0/45.91         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.8%         |           4.4%                     0.0%            | 
|TERMINAL (d)       |                  2/29 (7%)                2/31 (7%)    |           1/34 (3%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           597                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.672N     |                                    P=0.231N        | 
|POLY 3             |                                           P=0.677      |                                    P=0.234N        | 
|POLY 1.5           |                                           P=0.683      |                                    P=0.234N        | 
|POLY 6             |                                           P=0.671      |                                    P=0.235N        | 
|LOGISTIC REGRESSION|                                           P=0.672N     |                                    P=0.257N        | 
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.247N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  7/50 (14%)               0/50 (0%)    |                                                    | 
|POLY-3 RATE (b)    |                  7/44.80                  0/41.64      |                                                    | 
|POLY-3 PERCENT (g) |                  15.6%                    0.0%         |                                                    | 
|TERMINAL (d)       |                  4/29 (14%)               0/31 (0%)    |                                                    | 
|FIRST INCIDENCE    |                  673                      ---          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.011N*    |                                                    | 
|POLY 3             |                                           P=0.010N*    |                                                    | 
|POLY 1.5           |                                           P=0.009N**   |                                                    | 
|POLY 6             |                                           P=0.012N*    |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.012N*    |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.006N**   |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  49/50 (98%)              43/50 (86%)  |                                                    | 
|POLY-3 RATE (b)    |                  49/50.00                 43/46.74     |                                                    | 
|POLY-3 PERCENT (g) |                  98.0%                    92.0%        |                                                    | 
|TERMINAL (d)       |                  28/29 (97%)              30/31 (97%)  |                                                    | 
|FIRST INCIDENCE    |                  508                      505          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.187N     |                                                    | 
|POLY 3             |                                           P=0.153N     |                                                    | 
|POLY 1.5           |                                           P=0.073N     |                                                    | 
|POLY 6             |                                           P=0.361N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.087N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.030N*    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |                                                    | 
|POLY-3 RATE (b)    |                  2/44.60                  0/41.64      |                                                    | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%         |                                                    | 
|TERMINAL (d)       |                  1/29 (3%)                0/31 (0%)    |                                                    | 
|FIRST INCIDENCE    |                  690                      ---          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.250N     |                                                    | 
|POLY 3             |                                           P=0.261N     |                                                    | 
|POLY 1.5           |                                           P=0.251N     |                                                    | 
|POLY 6             |                                           P=0.271N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.254N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  5/50 (10%)               7/50 (14%)   |                                                    | 
|POLY-3 RATE (b)    |                  5/44.64                  7/42.98      |                                                    | 
|POLY-3 PERCENT (g) |                  11.2%                    16.3%        |                                                    | 
|TERMINAL (d)       |                  3/29 (10%)               4/31 (13%)   |                                                    | 
|FIRST INCIDENCE    |                  703                      577          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.380      |                                                    | 
|POLY 3             |                                           P=0.354      |                                                    | 
|POLY 1.5           |                                           P=0.363      |                                                    | 
|POLY 6             |                                           P=0.349      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.364      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.380      |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |                                                    | 
|POLY-3 RATE (b)    |                  1/44.44                  3/42.58      |                                                    | 
|POLY-3 PERCENT (g) |                  2.3%                     7.1%         |                                                    | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |                                                    | 
|FIRST INCIDENCE    |                  731 (T)                  508          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.295      |                                                    | 
|POLY 3             |                                           P=0.294      |                                                    | 
|POLY 1.5           |                                           P=0.298      |                                                    | 
|POLY 6             |                                           P=0.291      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.355      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.309      |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  21/50 (42%)              23/50 (46%)  |                                                    | 
|POLY-3 RATE (b)    |                  21/45.39                 23/46.81     |                                                    | 
|POLY-3 PERCENT (g) |                  46.3%                    49.1%        |                                                    | 
|TERMINAL (d)       |                  16/29 (55%)              13/31 (42%)  |                                                    | 
|FIRST INCIDENCE    |                  586                      499          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.455      |                                                    | 
|POLY 3             |                                           P=0.472      |                                                    | 
|POLY 1.5           |                                           P=0.446      |                                                    | 
|POLY 6             |                                           P=0.516      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.423      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.420      |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)    |                                                    | 
|POLY-3 RATE (b)    |                  2/44.53                  4/42.20      |                                                    | 
|POLY-3 PERCENT (g) |                  4.5%                     9.5%         |                                                    | 
|TERMINAL (d)       |                  1/29 (3%)                3/31 (10%)   |                                                    | 
|FIRST INCIDENCE    |                  709                      554          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.347      |                                                    | 
|POLY 3             |                                           P=0.316      |                                                    | 
|POLY 1.5           |                                           P=0.325      |                                                    | 
|POLY 6             |                                           P=0.309      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.320      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.339      |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  8/50 (16%)               5/50 (10%)   |           11/50 (22%)              19/50 (38%)     | 
|POLY-3 RATE (b)    |                  8/45.02                  5/41.64      |           11/45.74                 19/46.66        | 
|POLY-3 PERCENT (g) |                  17.8%                    12.0%        |           24.1%                    40.7%           | 
|TERMINAL (d)       |                  6/29 (21%)               5/31 (16%)   |           8/34 (24%)               16/36 (44%)     | 
|FIRST INCIDENCE    |                  583                      731 (T)      |           576                      597             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.248N     |                                    P=0.090         | 
|POLY 3             |                                           P=0.331N     |                                    P=0.065         | 
|POLY 1.5           |                                           P=0.309N     |                                    P=0.065         | 
|POLY 6             |                                           P=0.356N     |                                    P=0.065         | 
|LOGISTIC REGRESSION|                                           P=0.335N     |                                    P=0.070         | 
|COCH-ARM / FISHERS |                                           P=0.277N     |                                    P=0.063         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  16/50 (32%)              19/50 (38%)  |           10/50 (20%)              7/50 (14%)      | 
|POLY-3 RATE (b)    |                  16/45.09                 19/42.07     |           10/45.39                 7/45.91         | 
|POLY-3 PERCENT (g) |                  35.5%                    45.2%        |           22.0%                    15.3%           | 
|TERMINAL (d)       |                  13/29 (45%)              18/31 (58%)  |           8/34 (24%)               7/36 (19%)      | 
|FIRST INCIDENCE    |                  586                      606          |           676                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.399      |                                    P=0.256N        | 
|POLY 3             |                                           P=0.239      |                                    P=0.286N        | 
|POLY 1.5           |                                           P=0.278      |                                    P=0.287N        | 
|POLY 6             |                                           P=0.201      |                                    P=0.287N        | 
|LOGISTIC REGRESSION|                                           P=0.196      |                                    P=0.269N        | 
|COCH-ARM / FISHERS |                                           P=0.338      |                                    P=0.298N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                5/50 (10%)   |           12/50 (24%)              5/50 (10%)      | 
|POLY-3 RATE (b)    |                  2/44.44                  5/42.66      |           12/46.18                 5/46.09         | 
|POLY-3 PERCENT (g) |                  4.5%                     11.7%        |           26.0%                    10.9%           | 
|TERMINAL (d)       |                  2/29 (7%)                2/31 (7%)    |           8/34 (24%)               4/36 (11%)      | 
|FIRST INCIDENCE    |                  731 (T)                  499          |           576                      690             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.230      |                                    P=0.050N        | 
|POLY 3             |                                           P=0.201      |                                    P=0.052N        | 
|POLY 1.5           |                                           P=0.207      |                                    P=0.051N        | 
|POLY 6             |                                           P=0.197      |                                    P=0.053N        | 
|LOGISTIC REGRESSION|                                           P=0.220      |                                    P=0.052N        | 
|COCH-ARM / FISHERS |                                           P=0.218      |                                    P=0.054N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                2/50 (4%)    |           2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  3/44.44                  2/41.64      |           2/45.04                  1/45.91         | 
|POLY-3 PERCENT (g) |                  6.8%                     4.8%         |           4.4%                     2.2%            | 
|TERMINAL (d)       |                  3/29 (10%)               2/31 (7%)    |           2/34 (6%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.469N     |                                    P=0.480N        | 
|POLY 3             |                                           P=0.536N     |                                    P=0.491N        | 
|POLY 1.5           |                                           P=0.522N     |                                    P=0.493N        | 
|POLY 6             |                                           P=0.549N     |                                    P=0.489N        | 
|LOGISTIC REGRESSION|                                           P=0.469N     |                                    P=0.480N        | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                3/50 (6%)    |           1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  4/45.15                  3/42.48      |           1/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  8.9%                     7.1%         |           2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           1/34 (3%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  583                      554          |           735 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.530N     |                                    P=0.489N        | 
|POLY 3             |                                           P=0.538N     |                                    P=0.492N        | 
|POLY 1.5           |                                           P=0.523N     |                                    P=0.494N        | 
|POLY 6             |                                           P=0.552N     |                                    P=0.491N        | 
|LOGISTIC REGRESSION|                                           P=0.444N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.96                  1/41.64      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  4.5%                     2.4%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/31 (3%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  603                      731 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.503N     |                                    (e)             | 
|POLY 3             |                                           P=0.536N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.522N     |                                    (e)             | 
|POLY 6             |                                           P=0.552N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.489N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  5/50 (10%)               3/50 (6%)    |           1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  5/45.59                  3/42.48      |           1/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  11.0%                    7.1%         |           2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           1/34 (3%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  583                      554          |           735 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.394N     |                                    P=0.489N        | 
|POLY 3             |                                           P=0.401N     |                                    P=0.492N        | 
|POLY 1.5           |                                           P=0.383N     |                                    P=0.494N        | 
|POLY 6             |                                           P=0.419N     |                                    P=0.491N        | 
|LOGISTIC REGRESSION|                                           P=0.278N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.357N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  5/50 (10%)               2/50 (4%)    |           1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  5/45.78                  2/42.48      |           1/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  10.9%                    4.7%         |           2.2%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                0/31 (0%)    |           1/34 (3%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  524                      554          |           735 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.255N     |                                    P=0.489N        | 
|POLY 3             |                                           P=0.252N     |                                    P=0.492N        | 
|POLY 1.5           |                                           P=0.238N     |                                    P=0.494N        | 
|POLY 6             |                                           P=0.266N     |                                    P=0.491N        | 
|LOGISTIC REGRESSION|                                           P=0.119N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.218N     |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.44                  2/41.92      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  2.3%                     4.8%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/29 (3%)                1/31 (3%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  731 (T)                  655          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.491      |                                    (e)             | 
|POLY 3             |                                           P=0.487      |                                    (e)             | 
|POLY 1.5           |                                           P=0.492      |                                    (e)             | 
|POLY 6             |                                           P=0.483      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.478      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Epithelium                                                                                                   | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                4/50 (8%)    |           2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  4/42.92      |           2/46.02                  0/45.91         | 
|POLY-3 PERCENT (g) |                  0.0%                     9.3%         |           4.4%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                0/31 (0%)    |           1/34 (3%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  ---                      554          |           203                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.053      |                                    P=0.233N        | 
|POLY 3             |                                           P=0.057      |                                    P=0.238N        | 
|POLY 1.5           |                                           P=0.058      |                                    P=0.238N        | 
|POLY 6             |                                           P=0.056      |                                    P=0.237N        | 
|LOGISTIC REGRESSION|                                           P=0.088      |                                    P=0.415N        | 
|COCH-ARM / FISHERS |                                           P=0.059      |                                    P=0.247N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Glands                                                                                                       | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  34/50 (68%)              34/50 (68%)  |           39/50 (78%)              36/50 (72%)     | 
|POLY-3 RATE (b)    |                  34/47.37                 34/46.25     |           39/47.37                 36/47.98        | 
|POLY-3 PERCENT (g) |                  71.8%                    73.5%        |           82.3%                    75.0%           | 
|TERMINAL (d)       |                  21/29 (72%)              23/31 (74%)  |           29/34 (85%)              28/36 (78%)     | 
|FIRST INCIDENCE    |                  583                      499          |           576                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.539N     |                                    P=0.236N        | 
|POLY 3             |                                           P=0.519      |                                    P=0.259N        | 
|POLY 1.5           |                                           P=0.547      |                                    P=0.269N        | 
|POLY 6             |                                           P=0.484      |                                    P=0.254N        | 
|LOGISTIC REGRESSION|                                           P=0.473      |                                    P=0.263N        | 
|COCH-ARM / FISHERS |                                           P=0.585N     |                                    P=0.322N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  42/50 (84%)              38/50 (76%)  |                                                    | 
|POLY-3 RATE (b)    |                  42/48.25                 38/45.85     |                                                    | 
|POLY-3 PERCENT (g) |                  87.1%                    82.9%        |                                                    | 
|TERMINAL (d)       |                  27/29 (93%)              28/31 (90%)  |                                                    | 
|FIRST INCIDENCE    |                  524                      499          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.255N     |                                                    | 
|POLY 3             |                                           P=0.385N     |                                                    | 
|POLY 1.5           |                                           P=0.311N     |                                                    | 
|POLY 6             |                                           P=0.480N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.414N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.227N     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)    |                                                    | 
|POLY-3 RATE (b)    |                  4/44.44                  1/41.64      |                                                    | 
|POLY-3 PERCENT (g) |                  9.0%                     2.4%         |                                                    | 
|TERMINAL (d)       |                  4/29 (14%)               1/31 (3%)    |                                                    | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.158N     |                                                    | 
|POLY 3             |                                           P=0.203N     |                                                    | 
|POLY 1.5           |                                           P=0.194N     |                                                    | 
|POLY 6             |                                           P=0.212N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.158N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.181N     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  10/50 (20%)              8/50 (16%)   |                                                    | 
|POLY-3 RATE (b)    |                  10/46.93                 8/44.86      |                                                    | 
|POLY-3 PERCENT (g) |                  21.3%                    17.8%        |                                                    | 
|TERMINAL (d)       |                  3/29 (10%)               1/31 (3%)    |                                                    | 
|FIRST INCIDENCE    |                  508                      499          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.434N     |                                                    | 
|POLY 3             |                                           P=0.441N     |                                                    | 
|POLY 1.5           |                                           P=0.425N     |                                                    | 
|POLY 6             |                                           P=0.454N     |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.175N     |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.398N     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Ectopic Parathyroid Gland                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/43 (0%)                2/44 (5%)    |           4/43 (9%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  0/38.48                  2/36.92      |           4/40.36                  4/45.55         | 
|POLY-3 PERCENT (g) |                  0.0%                     5.4%         |           9.9%                     8.8%            | 
|TERMINAL (d)       |                  0/28 (0%)                1/28 (4%)    |           3/31 (10%)               4/36 (11%)      | 
|FIRST INCIDENCE    |                  ---                      554          |           203                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.235      |                                    P=0.570N        | 
|POLY 3             |                                           P=0.232      |                                    P=0.567N        | 
|POLY 1.5           |                                           P=0.235      |                                    P=0.564N        | 
|POLY 6             |                                           P=0.230      |                                    P=0.570N        | 
|LOGISTIC REGRESSION|                                           P=0.285      |                                    P=0.642N        | 
|COCH-ARM / FISHERS |                                           P=0.253      |                                    P=0.567N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.44                  1/41.64      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  6.8%                     2.4%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  3/29 (10%)               1/31 (3%)    |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  731 (T)                  731 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.280N     |                                    (e)             | 
|POLY 3             |                                           P=0.335N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.323N     |                                    (e)             | 
|POLY 6             |                                           P=0.346N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.280N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.309N     |                                    (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  17/50 (34%)              22/50 (44%)  |           23/50 (46%)              33/50 (66%)     | 
|POLY-3 RATE (b)    |                  17/45.23                 22/44.11     |           23/46.20                 33/47.68        | 
|POLY-3 PERCENT (g) |                  37.6%                    49.9%        |           49.8%                    69.2%           | 
|TERMINAL (d)       |                  12/29 (41%)              15/31 (48%)  |           18/34 (53%)              28/36 (78%)     | 
|FIRST INCIDENCE    |                  659                      554          |           597                      526             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.235      |                                    P=0.068         | 
|POLY 3             |                                           P=0.165      |                                    P=0.038 *       | 
|POLY 1.5           |                                           P=0.178      |                                    P=0.038 *       | 
|POLY 6             |                                           P=0.159      |                                    P=0.037 *       | 
|LOGISTIC REGRESSION|                                           P=0.129      |                                    P=0.039 *       | 
|COCH-ARM / FISHERS |                                           P=0.206      |                                    P=0.035 *       | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)    |           0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  2/44.68                  2/42.07      |           0/45.04                  2/45.91         | 
|POLY-3 PERCENT (g) |                  4.5%                     4.8%         |           0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/29 (0%)                1/31 (3%)    |           0/34 (0%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                  690                      606          |           ---                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.671      |                                    P=0.251         | 
|POLY 3             |                                           P=0.678      |                                    P=0.239         | 
|POLY 1.5           |                                           P=0.684      |                                    P=0.239         | 
|POLY 6             |                                           P=0.673      |                                    P=0.240         | 
|LOGISTIC REGRESSION|                                           P=0.690N     |                                    P=0.251         | 
|COCH-ARM / FISHERS |                                           P=0.691N     |                                    P=0.247         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.44                  3/41.64      |           0/45.04                  0/45.91         | 
|POLY-3 PERCENT (g) |                  0.0%                     7.2%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/29 (0%)                3/31 (10%)   |           0/34 (0%)                0/36 (0%)       | 
|FIRST INCIDENCE    |                  ---                      731 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.132      |                                    (e)             | 
|POLY 3             |                                           P=0.111      |                                    (e)             | 
|POLY 1.5           |                                           P=0.114      |                                    (e)             | 
|POLY 6             |                                           P=0.108      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.132      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.121      |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                                                        |           2/45.04                  2/45.91         | 
|POLY-3 PERCENT (g) |                                                        |           4.4%                     4.4%            | 
|TERMINAL (d)       |                                                        |           2/34 (6%)                2/36 (6%)       | 
|FIRST INCIDENCE    |                                                        |           735 (T)                  735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.675N        | 
|POLY 3             |                                                        |                                    P=0.685N        | 
|POLY 1.5           |                                                        |                                    P=0.687N        | 
|POLY 6             |                                                        |                                    P=0.684N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.675N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.691N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/18/01                           EXPERIMENT: 56111 TEST: 03                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   TRANS-CINNAMALDEHYDE                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           2/50 (4%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                                                        |           2/45.09                  5/45.91         | 
|POLY-3 PERCENT (g) |                                                        |           4.4%                     10.9%           | 
|TERMINAL (d)       |                                                        |           1/34 (3%)                5/36 (14%)      | 
|FIRST INCIDENCE    |                                                        |           723                      735 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.239         | 
|POLY 3             |                                                        |                                    P=0.222         | 
|POLY 1.5           |                                                        |                                    P=0.222         | 
|POLY 6             |                                                        |                                    P=0.223         | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.232         | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.218         | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).