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TDMS Study 56111-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                TRANS-CINNAMALDEHYDE                                          DATE: 06/14/01  
EXPERIMENT: 56111 TEST: 04                                                                                        TIME: 08:33:59    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56111B     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS LABORATORY                     TRANS-CINNAMALDEHYDE                                        DATE: 06/14/01    
EXPERIMENT: 56111 TEST: 04                                                                                        TIME:  8:55:36    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  56111B      
CONT: N01-ES-55384                                                                                                CAS: 14371-10-9   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                            CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                        
==================================================================================================================================  
      UNTREATDCONTROL             VEHICLE CONTROL                         .312%                              .625%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.5    22.2       4.4     22.8    0.98        0      4.4     22.4    0.98      614      4.3     22.0    0.96     1227       
  6     4.5    25.6       4.5     25.8    1.00        0      4.4     25.9    0.98      530      4.5     25.3    1.00     1121       
  9     4.7    29.3       4.8     29.9    1.02        0      4.6     29.2    0.98      493      4.8     28.3    1.02     1058       
 13     4.3    31.8       4.5     32.3    1.05        0      4.4     31.5    1.02      433      4.4     30.3    1.02      904       
 18     4.5    34.8       4.5     35.4    1.00        0      4.3     34.5    0.96      390      4.7     32.4    1.04      909       
 22     4.5    36.8       4.6     36.9    1.02        0      4.5     36.7    1.00      384      4.7     34.4    1.04      848       
 26     4.5    38.9       4.5     39.1    1.00        0      4.5     39.0    1.00      359      4.4     36.4    0.98      758       
 30     4.2    40.2       4.3     40.6    1.02        0      4.1     40.5    0.98      319      4.2     38.2    1.00      693       
 34     4.5    42.0       4.5     42.5    1.00        0      4.4     42.4    0.98      321      4.4     39.9    0.98      684       
 38     4.8    42.2       4.9     42.6    1.02        0      4.8     42.2    1.00      353      4.7     40.1    0.98      741       
 42     4.5    42.2       4.6     43.0    1.02        0      4.5     42.6    1.00      327      4.3     40.0    0.96      679       
 46     4.8    43.0       4.9     43.7    1.02        0      4.8     43.2    1.00      348      4.8     40.7    1.00      739       
 50     4.5    44.2       4.7     45.4    1.04        0      4.5     44.6    1.00      311      4.6     42.4    1.02      684       
 54     4.6    45.3       4.7     46.0    1.02        0      4.6     45.3    1.00      315      4.6     43.1    1.00      660       
 58     4.6    45.5       4.6     46.5    1.00        0      4.5     45.9    0.98      306      4.6     43.2    1.00      660       
 62     4.5    44.5       4.7     46.1    1.04        0      4.4     45.1    0.98      302      4.5     42.1    1.00      664       
 66     4.6    43.6       4.7     45.1    1.02        0      4.6     44.0    1.00      323      4.6     41.1    1.00      696       
 70     4.7    43.5       4.8     44.8    1.02        0      4.7     43.8    1.00      335      4.6     40.5    0.98      714       
 74     4.7    43.1       4.7     43.8    1.00        0      4.4     42.4    0.94      322      4.4     39.0    0.94      701       
 78     4.3    39.6       4.6     40.5    1.07        0      4.0     38.3    0.93      330      4.3     35.0    1.00      759       
 82     4.8    38.3       4.9     38.9    1.02        0      4.7     36.8    0.98      400      4.9     33.6    1.02      910       
 86     4.9    37.4       4.9     37.9    1.00        0      4.8     35.6    0.98      417      4.9     32.6    1.00      933       
 90     4.9    34.7       4.8     35.4    0.98        0      4.9     33.4    1.00      455      5.1     32.1    1.04      993       
 94     4.2    34.6       4.5     35.9    1.07        0      4.3     33.7    1.02      396      4.3     32.6    1.02      833       
 98     4.5    34.6       4.6     36.0    1.02        0      4.4     33.2    0.98      412      4.3     32.2    0.96      840       
102     4.5    34.8       4.6     35.6    1.02        0      4.3     33.1    0.96      406      4.5     32.3    1.00      870       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.5    27.2       4.5     27.7    1.01        0      4.4     27.2    0.99      517      4.5     26.5    1.00     1078       
SD(D)   0.2               0.2             0.03        0      0.1             0.02       76      0.2             0.03      135       
CV(E)   3.9               3.4             2.9                2.5             2.3      14.7      4.7             3.1      12.5       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6    40.5       4.6     41.0    1.02        0      4.5     40.6    0.99      346      4.5     38.3    1.00      748       
SD(D)   0.2               0.2             0.01        0      0.2             0.02       29      0.2             0.03       80       
CV(E)   3.8               4.4             1.5                4.7             1.6       8.3      4.6             3.1      10.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.6    40.0       4.7     41.0    1.02        0      4.5     39.3    0.98      363      4.6     36.9    1.00      787       
SD(D)   0.2               0.1             0.03        0      0.2             0.03       52      0.2             0.03      115       
CV(E)   4.2               2.9             2.6                5.1             2.7      14.3      5.4             2.8      14.7       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                                                                    
==========================================                                                                                          
                     1.25%                                                                                                          
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  2     4.3     22.0     0.96    2459                                                                                               
  6     4.5     24.5     1.00    2283                                                                                               
  9     4.8     27.5     1.02    2200                                                                                               
 13     4.4     29.0     1.02    1881                                                                                               
 18     4.5     31.8     1.00    1767                                                                                               
 22     4.7     33.2     1.04    1755                                                                                               
 26     4.4     35.7     0.98    1549                                                                                               
 30     4.3     36.8     1.02    1443                                                                                               
 34     4.2     38.1     0.93    1391                                                                                               
 38     4.7     38.1     0.98    1539                                                                                               
 42     4.3     38.1     0.96    1410                                                                                               
 46     4.6     38.6     0.96    1506                                                                                               
 50     4.5     40.3     1.00    1403                                                                                               
 54     4.4     41.0     0.96    1356                                                                                               
 58     4.3     40.9     0.93    1326                                                                                               
 62     4.4     40.1     0.98    1385                                                                                               
 66     4.5     39.0     0.98    1431                                                                                               
 70     4.3     38.2     0.91    1411                                                                                               
 74     4.3     36.3     0.91    1465                                                                                               
 78     4.3     32.8     1.00    1645                                                                                               
 82     4.7     32.0     0.98    1845                                                                                               
 86     4.8     31.6     0.98    1898                                                                                               
 90     4.6     32.3     0.94    1779                                                                                               
 94     4.1     32.1     0.98    1601                                                                                               
 98     4.3     32.0     0.96    1669                                                                                               
102     4.3     32.1     0.96    1671                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.5     25.7     1.00    2206                                                                                               
SD(D)   0.2              0.03     242                                                                                               
CV(E)   5.1              3.1     11.0                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5     36.7     0.99    1529                                                                                               
SD(D)   0.2              0.04     144                                                                                               
CV(E)   4.0              3.6      9.4                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.4     35.4     0.96    1576                                                                                               
SD(D)   0.2              0.03     193                                                                                               
CV(E)   4.4              2.8     12.3                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                            CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                        
==================================================================================================================================  
      UNTREATDCONTROL             VEHICLE CONTROL                         .312%                              .625%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.5    17.9       3.3     17.9     0.94       0      3.1     17.6     0.89     541      3.2     17.9     0.91    1129       
  2     3.6    18.8       3.5     18.8     0.97       0      3.6     18.4     1.00     611      3.5     18.5     0.97    1177       
  6     3.9    22.0       3.2     20.6     0.82       0      3.9     21.5     1.00     564      3.5     20.5     0.90    1065       
  9     4.1    24.7       4.1     24.6     1.00       0      4.2     24.4     1.02     534      4.1     23.9     1.00    1070       
 13     4.3    28.0       4.1     27.4     0.95       0      4.3     27.1     1.00     495      4.2     26.5     0.98    1001       
 18     4.2    31.5       4.6     31.5     1.10       0      4.5     31.1     1.07     449      4.6     29.7     1.10     965       
 22     4.7    34.1       4.3     33.8     0.91       0      4.7     33.4     1.00     440      4.8     32.5     1.02     920       
 26     4.7    35.8       4.5     36.5     0.96       0      4.7     36.1     1.00     410      4.8     35.5     1.02     836       
 30     4.2    36.8       4.2     36.2     1.00       0      3.9     36.3     0.93     338      4.2     35.3     1.00     735       
 34     4.5    39.6       4.6     39.5     1.02       0      4.6     38.9     1.02     373      4.8     38.4     1.07     779       
 38     4.4    39.9       4.3     40.0     0.98       0      4.3     38.8     0.98     346      4.3     38.3     0.98     700       
 42     4.3    40.8       4.5     40.8     1.05       0      4.4     39.7     1.02     347      4.4     38.9     1.02     712       
 46     4.9    41.6       4.8     41.8     0.98       0      4.5     40.4     0.92     351      4.6     39.2     0.94     740       
 50     4.6    42.8       4.4     43.2     0.96       0      4.3     41.7     0.93     323      4.2     40.1     0.91     652       
 54     4.6    43.7       4.8     44.2     1.04       0      4.7     43.2     1.02     341      4.8     41.8     1.04     717       
 58     4.4    44.7       4.4     45.2     1.00       0      4.4     44.1     1.00     313      4.4     42.7     1.00     644       
 62     4.4    44.9       4.5     45.4     1.02       0      4.6     44.0     1.05     329      4.6     41.9     1.05     680       
 66     4.4    44.2       4.3     43.4     0.98       0      4.3     43.2     0.98     314      4.5     40.9     1.02     694       
 70     4.7    45.2       4.5     44.8     0.96       0      4.8     43.3     1.02     348      4.2     40.7     0.89     652       
 74     5.0    45.3       5.0     46.0     1.00       0      4.9     43.9     0.98     351      4.9     40.9     0.98     748       
 78     4.2    42.7       3.8     42.7     0.90       0      4.3     41.2     1.02     322      4.2     37.1     1.00     712       
 82     4.3    40.8       4.3     40.2     1.00       0      4.4     39.9     1.02     347      4.6     34.8     1.07     834       
 86     4.7    39.6       4.6     40.0     0.98       0      4.6     39.6     0.98     361      5.0     34.1     1.06     922       
 90     4.8    37.8       4.9     39.2     1.02       0      5.0     38.3     1.04     404      4.9     34.1     1.02     892       
 94     4.4    38.8       4.1     39.0     0.93       0      4.5     37.7     1.02     372      5.0     34.7     1.14     894       
 98     4.9    40.2       5.0     40.9     1.02       0      4.7     39.2     0.96     376      5.0     35.5     1.02     883       
102     4.7    39.6       4.8     40.4     1.02       0      4.7     39.0     1.00     378      4.7     35.0     1.00     843       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.9    22.3       3.6     21.9     0.94       0      3.8     21.8     0.98     549      3.7     21.5     0.95    1088       
SD(D)   0.3               0.4              0.07       0      0.5              0.05      43      0.4              0.04      67       
CV(E)   8.9              11.6              7.4              13.0              5.6      7.8     11.7              4.6      6.2       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    38.1       4.5     38.1     0.99       0      4.5     37.4     0.99     375      4.5     36.4     1.01     782       
SD(D)   0.2               0.2              0.05       0      0.3              0.05      46      0.3              0.06     105       
CV(E)   5.2               3.8              5.4               5.6              5.2     12.3      5.6              5.7     13.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.6    42.1       4.5     42.4     0.99       0      4.6     41.3     1.01     350      4.7     38.0     1.02     778       
SD(D)   0.3               0.4              0.04       0      0.2              0.03      27      0.3              0.06     102       
CV(E)   5.6               8.0              4.0               4.8              2.7      7.8      5.9              5.5     13.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                                                                    
==========================================                                                                                          
                     1.25%                                                                                                          
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1     3.1     17.9     0.89    2205                                                                                               
  2     3.3     18.5     0.92    2259                                                                                               
  6     3.9     21.1     1.00    2305                                                                                               
  9     4.0     23.8     0.98    2119                                                                                               
 13     4.3     25.7     1.00    2083                                                                                               
 18     4.3     28.6     1.02    1875                                                                                               
 22     4.9     30.5     1.04    2012                                                                                               
 26     4.9     33.1     1.04    1849                                                                                               
 30     4.1     33.7     0.98    1537                                                                                               
 34     4.5     35.9     1.00    1579                                                                                               
 38     4.5     36.3     1.02    1558                                                                                               
 42     4.6     36.7     1.07    1548                                                                                               
 46     4.7     37.0     0.96    1591                                                                                               
 50     4.3     38.5     0.93    1386                                                                                               
 54     5.0     39.5     1.09    1585                                                                                               
 58     4.0     38.8     0.91    1299                                                                                               
 62     5.0     38.3     1.14    1617                                                                                               
 66     4.6     37.8     1.05    1515                                                                                               
 70     4.6     38.3     0.98    1491                                                                                               
 74     4.8     37.7     0.96    1576                                                                                               
 78     4.4     34.8     1.05    1572                                                                                               
 82     5.1     33.3     1.19    1926                                                                                               
 86     5.2     33.1     1.11    1979                                                                                               
 90     4.9     33.3     1.02    1840                                                                                               
 94     4.3     33.5     0.98    1596                                                                                               
 98     4.5     33.6     0.92    1667                                                                                               
102     4.7     34.2     1.00    1718                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.7     21.4     0.96    2194                                                                                               
SD(D)   0.5              0.05      93                                                                                               
CV(E)  12.7              5.4      4.2                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5     34.5     1.01    1660                                                                                               
SD(D)   0.3              0.04     203                                                                                               
CV(E)   5.9              4.4     12.3                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.7     35.9     1.03    1645                                                                                               
SD(D)   0.4              0.08     185                                                                                               
CV(E)   7.5              8.1     11.3                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               20.6  50                 21.1  50                 20.8  50                 20.6  50                 20.6  50      
  1               20.6  50                 21.1  50                 20.8  50                 20.6  50                 20.6  50      
  2   4.5  8183   22.2  50     4.4  8198   22.8  50     4.4  8208   22.4  50     4.3  8245   22.0  50     4.3  8245   22.0  50      
  5   6.4    27                                                                                           7.1    27                 
  6   4.5  8181   25.6  50     4.5  8265   25.8  50     4.4  8294   25.9  50     4.5  8346   25.3  50     4.5  8363   24.5  50      
  9   4.7  8391   29.3  50     4.8  8394   29.9  50     4.6  8239   29.2  49     4.8  8312   28.3  50     4.8  8403   27.5  50      
 13   4.3  8400   31.8  50     4.5  8400   32.3  50     4.4  8252   31.5  49     4.4  8450   30.3  50     4.4  8468   29.0  50      
 18   4.5  8431   34.8  50     4.5  8239   35.4  49     4.3  8254   34.5  49     4.7  8450   32.4  50     4.5  8466   31.8  50      
 22   4.5  8412   36.8  50     4.6  8256   36.9  49     4.5  8261   36.7  49     4.7  8459   34.4  50     4.7  8431   33.2  50      
 26   4.5  8338   38.9  50     4.5  8188   39.1  49     4.5  8205   39.0  49     4.4  8400   36.4  50     4.4  8433   35.7  50      
 30   4.2  8428   40.2  49     4.3  8428   40.6  49     4.1  8428   40.5  49     4.2  8600   38.2  50     4.3  8557   36.8  50      
 34   4.5  8363   42.0  49     4.5  8378   42.5  49     4.4  8379   42.4  49     4.4  8572   39.9  50     4.2  8592   38.1  50      
 38   4.8  8164   42.2  49     4.9  8215   42.6  49     4.8  8232   42.2  49     4.7  8433   40.1  50     4.7  8435   38.1  50      
 42   4.5  8318   42.2  49     4.6  8355   43.0  49     4.5  8373   42.6  49     4.3  8551   40.0  50     4.3  8583   38.1  50      
 46   4.8  8281   43.0  49     4.9  8330   43.7  49     4.8  8303   43.2  49     4.8  8497   40.7  50     4.6  8498   38.6  50      
 50   4.5  8186   44.2  48     4.7  8271   45.4  49     4.5  8247   44.6  49     4.6  8367   42.4  50     4.5  8306   40.3  50      
 54   4.6  8064   45.3  48     4.7  8221   46.0  49     4.6  8232   45.3  49     4.6  8232   43.1  49     4.4  8412   41.0  50      
 58   4.6  8084   45.5  48     4.6  8249   46.5  49     4.5  8122   45.9  49     4.6  8186   43.2  49     4.3  8361   40.9  50      
 62   4.5  8095   44.5  48     4.7  8281   46.1  49     4.4  8306   45.1  49     4.5  8319   42.1  49     4.4  8476   40.1  50      
 66   4.6  8107   43.6  48     4.7  8279   45.1  49     4.6  8281   44.0  49     4.6  8330   41.1  49     4.5  8472   39.0  50      
 70   4.7  8035   43.5  48     4.8  8190   44.8  49     4.7  8195   43.8  49     4.6  8227   40.5  49     4.3  8400   38.2  50      
 74   4.7  7896   43.1  47     4.7  8235   43.8  49     4.4  8260   42.4  49     4.4  8106   39.0  48     4.3  8495   36.3  50      
 78   4.3  7755   39.6  46     4.6  8344   40.5  49     4.0  8337   38.3  49     4.3  7779   35.0  46     4.3  8455   32.8  50      
 82   4.8  7590   38.3  46     4.9  8098   38.9  49     4.7  8107   36.8  49     4.9  7290   33.6  44     4.7  8283   32.0  50      
 86   4.9  7716   37.4  46     4.9  8064   37.9  48     4.8  8064   35.6  48     4.9  7224   32.6  43     4.8  8232   31.6  50      
 90   4.9  7797   34.7  46     4.8  8204   35.4  48     4.9  8208   33.4  48     5.1  7184   32.1  43     4.6  8379   32.3  49      
 94   4.2  7640   34.6  46     4.5  7997   35.9  48     4.3  7847   33.7  47     4.3  6867   32.6  41     4.1  8232   32.1  49      
 98   4.5  7627   34.6  45     4.6  8163   36.0  48     4.4  8014   33.2  47     4.3  7011   32.2  41     4.3  8386   32.0  49      
102   4.5  7476   34.8  44     4.6  8038   35.6  47     4.3  7872   33.1  46     4.5  6684   32.3  39     4.3  8423   32.1  49      
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               17.9  50                 17.9  50                 17.6  50                 17.9  50                 17.9  50      
  1   3.5  4860   17.9  50     3.3  4860   17.9  50     3.1  4855   17.6  50     3.2  4860   17.9  50     3.1  4865   17.9  50      
  2   3.6  3420   18.8  50     3.5  3425   18.8  50     3.6  3430   18.4  50     3.5  3439   18.5  50     3.3  3445   18.5  50      
  5   3.6  4735                3.7  4750                3.5  4740                3.5  4745                3.4  4745                 
  6   3.9  3601   22.0  50     3.2  3608   20.6  50     3.9  3618   21.5  50     3.5  3639   20.5  50     3.9  3653   21.1  50      
  9   4.1  8470   24.7  50     4.1  8485   24.6  50     4.2  8494   24.4  50     4.1  8501   23.9  50     4.0  8506   23.8  50      
 13   4.3  8427   28.0  50     4.1  8436   27.4  50     4.3  8443   27.1  50     4.2  8455   26.5  50     4.3  8464   25.7  50      
 17   4.1  4640                4.3  4635                4.1  4640                4.5  4635                4.3  4640                 
 18   4.2  3603   31.5  50     4.6  3614   31.5  50     4.5  3621   31.1  50     4.6  3632   29.7  50     4.3  3643   28.6  50      
 21   4.1  4550                4.4  4560                4.3  4560                4.7  4570                4.5  4570                 
 22   4.7  3612   34.1  50     4.3  3622   33.8  50     4.7  3637   33.4  50     4.8  3649   32.5  50     4.9  3662   30.5  50      
 25   4.4  4630                4.4  4630                4.2  4630                4.3  4630                4.6  4630                 
 26   4.7  3636   35.8  50     4.5  3648   36.5  50     4.7  3662   36.1  50     4.8  3671   35.5  50     4.9  3680   33.1  50      
 29   3.8  4895                4.1  4900                3.8  4900                4.0  4860                3.9  4868                 
 30   4.2  3575   36.8  50     4.2  3587   36.2  50     3.9  3599   36.3  50     4.2  3611   35.3  50     4.1  3625   33.7  50      
 33   4.2  4890                4.2  4890                4.1  4891                4.2  4900                4.0  4826                 
 34   4.5  3715   39.6  50     4.6  3686   39.5  50     4.6  3645   38.9  50     4.8  3654   38.4  50     4.5  3531   35.9  49      
 37   3.6  5060                3.7  5085                3.6  5068                3.6  5055                4.0  4939                 
 38   4.4  3348   39.9  50     4.3  3342   40.0  50     4.3  3373   38.8  50     4.3  3401   38.3  50     4.5  3358   36.3  49      
 41   4.3  4855                4.2  4860                4.2  4860                4.3  4865                4.3  4768                 
 42   4.3  3571   40.8  50     4.5  3578   40.8  50     4.4  3585   39.7  50     4.4  3594   38.9  50     4.6  3524   36.7  49      
 45   4.3  4790                4.1  4790                4.1  4790                4.2  4765                4.2  4645                 
 46   4.9  3639   41.6  50     4.8  3658   41.8  50     4.5  3686   40.4  50     4.6  3732   39.2  50     4.7  3680   37.0  49      
 49   3.9  4777                4.1  4770                4.0  4655                4.0  4750                4.1  4646                 
 50   4.6  3712   42.8  50     4.4  3731   43.2  50     4.3  3671   41.7  49     4.2  3758   40.1  50     4.3  3695   38.5  49      
 53   3.9  5000                4.0  5000                4.1  4861                4.1  4960                4.1  4861                 
 54   4.6  3465   43.7  50     4.8  3477   44.2  50     4.7  3421   43.2  49     4.8  3502   41.8  50     5.0  3442   39.5  49      
 57   4.2  4670                3.8  4670                4.3  4577                4.2  4620                4.2  4437                 
 58   4.4  3812   44.7  50     4.4  3825   45.2  50     4.4  3773   44.1  49     4.4  3839   42.7  50     4.0  3653   38.8  48      
 61   4.0  4835                3.9  4840                4.0  4743                3.9  4840                4.3  4646                 
 62   4.4  3458   44.9  50     4.5  3477   45.4  50     4.6  3426   44.0  49     4.6  3442   41.9  49     5.0  3391   38.3  48      
 65   3.9  4772                3.9  4860                4.0  4766                4.1  4763                4.4  4666                 
 66   4.4  3631   44.2  49     4.3  3720   43.4  49     4.3  3663   43.2  49     4.5  3677   40.9  49     4.6  3614   37.8  48      
 69   4.2  4685                4.1  4490                4.1  4684                3.8  4679                4.4  4578                 
 70   4.7  3378   45.2  49     4.5  3251   44.8  47     4.8  3398   43.3  49     4.2  3443   40.7  49     4.6  3383   38.3  48      
 73   4.1  4988                4.0  4789                4.1  4993                4.1  4993                3.9  4896                 
 74   5.0  3225   45.3  49     5.0  3103   46.0  47     4.9  3247   43.9  49     4.9  3258   40.9  49     4.8  3200   37.7  48      
 77   4.0  4637                4.0  4542                3.8  4910                3.5  4910                3.8  4812                 
 78   4.2  3456   42.7  48     3.8  3392   42.7  47     4.3  3386   41.2  49     4.2  3396   37.1  49     4.4  3338   34.8  48      
 81   4.1  4626                4.0  4527                4.1  4522                4.0  4710                4.5  4608                 
 82   4.3  3406   40.8  48     4.3  3067   40.2  47     4.4  3370   39.9  47     4.6  3531   34.8  49     5.1  3476   33.3  48      
 85   3.8  4618                4.1  4440                4.1  4434                3.9  4633                4.1  4441                 
 86   4.7  3450   39.6  48     4.6  3286   40.0  46     4.6  3245   39.6  45     5.0  3377   34.1  48     5.2  3238   33.1  46      
 89   4.2  4642                4.3  4258                4.2  4355                4.4  4646                4.2  4459                 
 90   4.8  3329   37.8  48     4.9  3090   39.2  44     5.0  3164   38.3  45     4.9  3380   34.1  48     4.9  3243   33.3  46      
 93   3.6  4627                3.8  4424                3.7  4429                3.8  4622                3.5  4501                 
 94   4.4  3083   38.8  46     4.1  2966   39.0  44     4.5  2977   37.7  44     5.0  3122   34.7  46     4.3  3064   33.5  45      
 97   4.3  4170                4.4  4223                4.6  3840                4.3  4416                4.1  4322                 
 98   4.9  3138   40.2  43     5.0  3227   40.9  44     4.7  2946   39.2  40     5.0  3397   35.5  46     4.5  3337   33.6  45      
101   4.1  4186                4.4  4088                4.4  3894                4.4  4384                4.2  4288                 
==================================================================================================================================  
                                                                                                                                   
                                           DIAGNOSTIC TRAILER REPORT                                                                
                                           FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                           CHRONIC DOSED FEED STUDY OF TRANS-CINNAMALDEHYDE                                         
==================================================================================================================================  
      UNTREATDCONTROL          VEHICLE CONTROL               .312%                    .625%                    1.25%                
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS     
=================================================================================================================================== 
102   4.7  3069   39.6  43     4.8  3008   40.4  42     4.7  2875   39.0  40     4.7  3250   35.0  45     4.7  3190   34.2  44      
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.