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https://ntp.niehs.nih.gov/go/5706

TDMS Study 56111-04 Pathology Tables

NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01
Route: DOSED FEED                                                                                                 Time: 14:40:37

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  14371-10-9

       Lock Date:  06/28/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Natural Death                                      5            6            9            5            3                        
    Moribund Sacrifice                                 2            3            4            1            4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           41           36           44           43                        
    Natural Death                                      1                         1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (50)                      
      Hyperkeratosis                                   2 (4%)       1 (2%)       2 (4%)       1 (2%)       1 (2%)                   
   Gallbladder                                        (50)         (50)         (50)         (50)         (50)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation                                     3 (6%)       6 (12%)      5 (10%)      5 (10%)      3 (6%)                   
   Intestine Small, Duodenum                          (50)         (49)         (50)         (50)         (50)                      
      Necrosis                                                      1 (2%)                                                          
      Regeneration                                                  1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Atrophy                                           1 (2%)                                                          
      Peyer's Patch, Hyperplasia                                                 1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
   Liver                                              (50)         (49)         (50)         (50)         (50)                      
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                 1 (2%)       4 (8%)       2 (4%)       1 (2%)                                
      Eosinophilic Focus                               3 (6%)       1 (2%)       2 (4%)                                             
      Fatty Change                                     5 (10%)      4 (8%)       8 (16%)      4 (8%)       7 (14%)                  
      Hematopoietic Cell Proliferation                 4 (8%)       6 (12%)      3 (6%)       2 (4%)       5 (10%)                  
      Infiltration Cellular, Lymphocyte                             1 (2%)                    1 (2%)                                
      Inflammation                                    39 (78%)     42 (86%)     36 (72%)     38 (76%)     41 (82%)                  
      Mixed Cell Focus                                 2 (4%)       1 (2%)       3 (6%)                                             
      Necrosis                                         6 (12%)      2 (4%)       2 (4%)       1 (2%)       3 (6%)                   
      Pigmentation                                     2 (4%)       3 (6%)       4 (8%)       2 (4%)       4 (8%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)       2 (4%)                    1 (2%)                   
      Portal, Infiltration Cellular, Lymphocyte       26 (52%)     32 (65%)     25 (50%)     31 (62%)     26 (52%)                  
   Mesentery                                          (3)          (4)          (5)          (4)          (1)                       
      Inflammation                                                  1 (25%)                                                         
      Fat, Mineralization                                                        2 (40%)                   1 (100%)                 
      Fat, Necrosis                                                 3 (75%)      2 (40%)      1 (25%)      1 (100%)                 
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Cyst                                             1 (2%)                                 1 (2%)       1 (2%)                   
      Inflammation                                    21 (42%)     25 (50%)     16 (32%)     24 (48%)     18 (36%)                  
   Salivary Glands                                    (48)         (50)         (48)         (49)         (50)                      
      Atrophy                                                                                              1 (2%)                   
      Inflammation                                    25 (52%)     32 (64%)     27 (56%)     27 (55%)     27 (54%)                  
      Mineralization                                                                                       1 (2%)                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Hyperkeratosis                                   3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Inflammation                                                               1 (2%)                                             
      Ulcer                                            1 (2%)                                              2 (4%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                                                         1 (2%)                   
      Mineralization                                   1 (2%)       2 (4%)       1 (2%)       1 (2%)       3 (6%)                   
   Tooth                                                           (2)                       (1)          (1)                       
      Malformation                                                  1 (50%)                   1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (50)                      
      Aorta, Inflammation                              1 (2%)                                 1 (2%)       1 (2%)                   
   Heart                                              (49)         (50)         (50)         (50)         (50)                      
      Cardiomyopathy                                                1 (2%)       1 (2%)                    2 (4%)                   
      Inflammation                                     1 (2%)       1 (2%)       2 (4%)       1 (2%)       2 (4%)                   
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Artery, Inflammation                                          1 (2%)                                 2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)                                                          
      Hyperplasia                                      2 (4%)       2 (4%)       6 (12%)      2 (4%)       2 (4%)                   
      Hypertrophy                                      4 (8%)       4 (8%)       2 (4%)       2 (4%)       1 (2%)                   
      Pigmentation                                    32 (64%)     34 (68%)     26 (52%)     32 (64%)     29 (58%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                       36 (72%)     34 (68%)     31 (62%)     37 (74%)     33 (66%)                  
      Subcapsular, Hyperplasia                        50 (100%)    49 (98%)     50 (100%)    50 (100%)    49 (98%)                  
   Adrenal Medulla                                    (49)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      1 (2%)       3 (6%)       4 (8%)                    2 (4%)                   
   Parathyroid Gland                                  (41)         (44)         (40)         (41)         (44)                      
      Cyst                                                          1 (2%)                                                          
   Pituitary Gland                                    (48)         (49)         (50)         (49)         (50)                      
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation                                                                                         1 (2%)                   
      Pars Distalis, Hyperplasia                       5 (10%)      5 (10%)      6 (12%)      2 (4%)       4 (8%)                   
   Thyroid Gland                                      (48)         (50)         (49)         (50)         (50)                      
      Inflammation                                                  2 (4%)                                                          
      Follicle, Cyst                                   7 (15%)      3 (6%)       4 (8%)      10 (20%)      4 (8%)                   
      Follicular Cell, Hyperplasia                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (49)         (50)         (49)         (50)                      
      Cyst                                                          1 (2%)                                                          
      Inflammation                                    32 (64%)     35 (71%)     30 (60%)     36 (73%)     33 (66%)                  
      Inflammation, Suppurative                        1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (49)         (50)                      
      Angiectasis                                      1 (2%)                    1 (2%)                    1 (2%)                   
      Cyst                                            13 (26%)      9 (18%)      8 (16%)     11 (22%)     11 (22%)                  
      Cyst, Multiple                                                1 (2%)                                                          
      Inflammation                                     1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                   1 (2%)       2 (4%)       1 (2%)       1 (2%)       3 (6%)                   
   Oviduct                                            (1)          (1)          (2)          (3)          (4)                       
      Inflammation                                                  1 (100%)                               1 (25%)                  
   Uterus                                             (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                                1 (2%)                    1 (2%)                   
      Hydrometra                                       1 (2%)                                 1 (2%)                                
      Inflammation                                     1 (2%)       7 (14%)      3 (6%)       2 (4%)       6 (12%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Ulcer                                                         1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                43 (86%)     42 (84%)     46 (92%)     41 (82%)     48 (96%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                     11 (22%)     10 (20%)     10 (20%)     12 (24%)     12 (24%)                  
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Lymph Node                                         (7)          (5)          (7)          (10)         (7)                       
      Lumbar, Infiltration Cellular, Plasma Cell       1 (14%)                                                                      
      Renal, Ectasia                                   1 (14%)                                                                      
   Lymph Node, Mandibular                             (46)         (47)         (45)         (49)         (47)                      
      Atrophy                                          2 (4%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                    1 (2%)                   
   Lymph Node, Mesenteric                             (49)         (49)         (50)         (49)         (50)                      
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                       1 (2%)                                                          
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Infiltration Cellular, Plasma Cell                                                      1 (2%)                                
      Inflammation                                                               1 (2%)                                             
   Spleen                                             (48)         (49)         (50)         (50)         (50)                      
      Hematopoietic Cell Proliferation                11 (23%)     16 (33%)     15 (30%)      9 (18%)     11 (22%)                  
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
      Lymphoid Follicle, Atrophy                                                 2 (4%)       2 (4%)                                
      Lymphoid Follicle, Hyperplasia                   2 (4%)       4 (8%)       1 (2%)                    4 (8%)                   
   Thymus                                             (46)         (47)         (46)         (47)         (47)                      
      Atrophy                                          5 (11%)      2 (4%)       3 (7%)       2 (4%)       1 (2%)                   
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                      1 (2%)                                              1 (2%)                   
      Inflammation                                                                            1 (2%)                                
      Duct, Dilatation                                                           1 (2%)       1 (2%)       1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Hyperkeratosis                                                                                       1 (2%)                   
      Subcutaneous Tissue, Inflammation                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Myelofibrosis                                   24 (48%)     27 (54%)     23 (46%)     34 (68%)     38 (76%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)         (50)                      
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
      Choroid Plexus, Infiltration Cellular,                                                                                        
          Lymphocyte                                                             1 (2%)                                             
      Choroid Plexus, Inflammation                                                                         1 (2%)                   
      Medulla, Degeneration                                                                                1 (2%)                   
      Meninges, Infiltration Cellular, Lymphocyte                   1 (2%)                    1 (2%)                                
      Meninges, Inflammation                           2 (4%)                                                                       
   Spinal Cord                                                                                            (1)                       
      Degeneration                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Infiltration Cellular, Lymphocyte                1 (2%)                                 1 (2%)                                
      Inflammation                                                  1 (2%)                    3 (6%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    2 (4%)       1 (2%)                   
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                                                       1 (2%)                    1 (2%)                   
   Nose                                               (49)         (50)         (50)         (50)         (50)                      
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Inflammation                                     2 (4%)       5 (10%)      3 (6%)       4 (8%)       2 (4%)                   
      Glands, Inflammation, Focal, Granulomatous                    1 (2%)                                                          
      Nasolacrimal Duct, Inflammation                  2 (4%)       1 (2%)                                                          
      Olfactory Epithelium, Degeneration, Hyaline     17 (35%)     23 (46%)     25 (50%)     22 (44%)                               
      Olfactory Epithelium, Pigmentation                                                      8 (16%)     46 (92%)                  
   Trachea                                            (48)         (50)         (49)         (50)         (50)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)          (1)                                    
      Cornea, Hyperplasia                                                        1 (100%)                                           
      Cornea, Inflammation                                                       1 (100%)     1 (100%)                              
   Harderian Gland                                    (2)          (1)          (4)          (5)                                    
      Inflammation                                     2 (100%)                  1 (25%)      2 (40%)                               
   Lacrimal Gland                                                                            (1)                                    
      Inflammation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                                                                 1 (2%)       1 (2%)                   
      Cyst                                                                                                 1 (2%)                   
      Hydronephrosis                                   1 (2%)       1 (2%)                    1 (2%)                                
      Infarct                                          1 (2%)       1 (2%)                                 2 (4%)                   
      Infiltration Cellular, Lymphocyte               37 (74%)     44 (88%)     39 (78%)     42 (84%)     37 (74%)                  
      Inflammation                                     1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Metaplasia, Osseous                                           1 (2%)       1 (2%)       3 (6%)       1 (2%)                   
      Mineralization                                   4 (8%)       4 (8%)       1 (2%)       2 (4%)       6 (12%)                  
      Necrosis                                         1 (2%)                                                                       
      Nephropathy                                      7 (14%)     11 (22%)      4 (8%)      12 (24%)      8 (16%)                  
      Artery, Inflammation                                                                                 1 (2%)                   
      Papilla, Necrosis                                                                       1 (2%)                                
      Renal Tubule, Dilatation                        24 (48%)     25 (50%)     30 (60%)     22 (44%)     32 (64%)                  
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                    34 (68%)     33 (66%)     39 (78%)     33 (66%)     33 (66%)                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            4            9                                     
    Moribund Sacrifice                                                                        2            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           45           46           39           49                        
    Natural Death                                      1            2                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (50)                      
      Hyperkeratosis                                   4 (8%)       2 (4%)       2 (4%)       4 (8%)                                
   Gallbladder                                        (50)         (50)         (50)         (50)         (49)                      
      Inflammation                                     2 (4%)       4 (8%)       2 (4%)       2 (4%)       4 (8%)                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Edema                                                                      1 (2%)                                             
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (50)                      
      Lymphoid Tissue, Hyperplasia                                                                         1 (2%)                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (49)                      
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Diverticulum                                                                            1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation                                     1 (2%)                                                                       
      Peyer's Patch, Hyperplasia                       2 (4%)                                                                       
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 2 (4%)       1 (2%)       1 (2%)                    1 (2%)                   
      Clear Cell Focus                                 2 (4%)       3 (6%)       3 (6%)       1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Eosinophilic Focus                               3 (6%)       1 (2%)       3 (6%)       2 (4%)       1 (2%)                   
      Fatty Change                                     3 (6%)       3 (6%)       4 (8%)       4 (8%)       2 (4%)                   
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                    26 (52%)     33 (66%)     34 (68%)     28 (56%)     27 (54%)                  
      Mitotic Alteration                                                                                   1 (2%)                   
      Mixed Cell Focus                                 3 (6%)       5 (10%)      3 (6%)       3 (6%)       6 (12%)                  
      Necrosis                                         3 (6%)       6 (12%)      4 (8%)       4 (8%)       3 (6%)                   
      Pigmentation                                     1 (2%)                    1 (2%)       1 (2%)       1 (2%)                   
      Vacuolization Cytoplasmic                                                                            1 (2%)                   
      Bile Duct, Cyst                                                                                      1 (2%)                   
      Centrilobular, Degeneration                                                             1 (2%)                                
      Portal, Infiltration Cellular, Lymphocyte        1 (2%)       3 (6%)       6 (12%)      8 (16%)      3 (6%)                   
   Mesentery                                          (2)                                    (1)                                    
      Fat, Inflammation                                1 (50%)                                                                      
      Fat, Necrosis                                    1 (50%)                                                                      
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                                       1 (2%)                                                          
      Cyst                                             2 (4%)                                                                       
      Inflammation                                     8 (16%)     10 (20%)      8 (16%)     14 (28%)     10 (20%)                  
   Salivary Glands                                    (50)         (50)         (50)         (49)         (50)                      
      Atrophy                                                       3 (6%)                    1 (2%)                                
      Inflammation                                    30 (60%)     31 (62%)     33 (66%)     26 (53%)     29 (58%)                  
      Mineralization                                                                          2 (4%)                                
   Stomach, Forestomach                               (48)         (50)         (50)         (48)         (50)                      
      Hyperkeratosis                                   2 (4%)                    2 (4%)       3 (6%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
      Mineralization                                                                                       1 (2%)                   
      Ulcer                                                                                   1 (2%)                                
   Tooth                                                           (1)                       (1)          (2)                       
      Malformation                                                  1 (100%)                  1 (100%)     2 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (50)         (50)         (50)                      
      Aorta, Inflammation                              1 (2%)                                 1 (2%)                                
      Aorta, Thrombosis                                1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Cardiomyopathy                                   1 (2%)       2 (4%)       1 (2%)       2 (4%)       1 (2%)                   
      Inflammation                                     1 (2%)                    1 (2%)       1 (2%)                                
      Mineralization                                                                          5 (10%)                               
      Artery, Inflammation                             1 (2%)                                 1 (2%)       2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)         (50)                      
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hypertrophy                                     23 (47%)     23 (46%)     22 (44%)     24 (49%)     19 (38%)                  
      Subcapsular, Hyperplasia                        39 (80%)     46 (92%)     43 (86%)     44 (90%)     42 (84%)                  
   Adrenal Medulla                                    (49)         (50)         (50)         (49)         (50)                      
      Hyperplasia                                                                1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                      4 (8%)       4 (8%)       5 (10%)      3 (6%)       4 (8%)                   
   Pituitary Gland                                    (48)         (50)         (49)         (50)         (49)                      
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             2 (4%)       1 (2%)       3 (6%)                                             
      Pars Distalis, Hyperplasia                       5 (10%)      5 (10%)      6 (12%)      4 (8%)       5 (10%)                  
   Thyroid Gland                                      (50)         (49)         (50)         (50)         (50)                      
      Inflammation                                                               1 (2%)       1 (2%)                                
      Follicle, Cyst                                   6 (12%)      4 (8%)       4 (8%)       5 (10%)      5 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                       (1)                                    
      Inflammation                                                  1 (100%)                  1 (100%)                              
   Epididymis                                         (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Mineralization                                                3 (6%)                    2 (4%)       2 (4%)                   
   Preputial Gland                                    (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                    26 (52%)     29 (58%)     31 (62%)     27 (54%)     22 (44%)                  
      Duct, Ectasia                                   15 (30%)     20 (40%)     27 (54%)     17 (34%)     13 (26%)                  
      Duct, Hyperplasia, Squamous                                                             1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)         (50)                      
      Mineralization                                   1 (2%)                    3 (6%)       3 (6%)       1 (2%)                   
      Germinal Epithelium, Degeneration                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Hyperplasia                                     17 (34%)     14 (28%)     19 (38%)     20 (40%)     13 (26%)                  
      Necrosis                                                                                1 (2%)                                
   Lymph Node                                         (3)          (2)          (2)          (3)          (2)                       
      Mediastinal, Hyperplasia                         1 (33%)                                                                      
   Lymph Node, Mandibular                             (49)         (49)         (49)         (46)         (48)                      
      Atrophy                                                                    1 (2%)       1 (2%)       1 (2%)                   
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Pigmentation, Hemosiderin                                                                            1 (2%)                   
   Lymph Node, Mesenteric                             (48)         (49)         (46)         (46)         (50)                      
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                          3 (6%)       1 (2%)                    2 (4%)                                
      Ectasia                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              2 (4%)                    1 (2%)       1 (2%)                   
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia                                      2 (4%)                                              1 (2%)                   
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Plasma Cell                                         1 (2%)       1 (2%)       1 (2%)                   
      Inflammation                                                                            1 (2%)       1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (49)         (50)                      
      Hematopoietic Cell Proliferation                 7 (14%)      8 (16%)     10 (20%)      8 (16%)      5 (10%)                  
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia                                                                             1 (2%)       1 (2%)                   
      Lymphoid Follicle, Atrophy                                    1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
   Thymus                                             (44)         (43)         (44)         (44)         (49)                      
      Atrophy                                                       2 (5%)       3 (7%)       3 (7%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                                            1 (2%)                                
      Subcutaneous Tissue, Edema                                                 1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Myelofibrosis                                    1 (2%)       1 (2%)       1 (2%)                    1 (2%)                   
   Skeletal Muscle                                                              (1)                                                 
      Inflammation                                                               1 (100%)                                           
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
      Cerebellum, Necrosis                                                                                 1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                     1 (2%)                    1 (2%)       3 (6%)       1 (2%)                   
      Inflammation, Granulomatous                                                             1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (8%)       2 (4%)       7 (14%)                   5 (10%)                  
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                                                                    1 (2%)                                
   Nose                                               (48)         (48)         (48)         (48)         (50)                      
      Foreign Body                                     1 (2%)       1 (2%)       3 (6%)                    3 (6%)                   
      Inflammation                                     3 (6%)       2 (4%)       6 (13%)                   4 (8%)                   
      Nasolacrimal Duct, Foreign Body                                            2 (4%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation                               2 (4%)       2 (4%)       1 (2%)       3 (6%)                   
      Olfactory Epithelium, Degeneration, Hyaline                   2 (4%)       1 (2%)                                             
      Olfactory Epithelium, Pigmentation                                                      3 (6%)      26 (52%)                  
      Olfactory Epithelium, Respiratory Epithelium,                                                                                 
           Degeneration                                                          1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (4)          (4)          (1)          (3)                       
      Inflammation                                     1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             2 (4%)       3 (6%)                    3 (6%)       3 (6%)                   
      Cytoplasmic Alteration                                                                               1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 56111-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                        TRANS-CINNAMALDEHYDE                                   Date: 09/26/01    
Route: DOSED FEED                                                                                                 Time: 14:40:37    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     VEHICLE      .312%        .625%        1.25%                        
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Fibrosis                                                                                1 (2%)                                
      Infarct                                          2 (4%)       5 (10%)      2 (4%)       2 (4%)                                
      Infiltration Cellular, Lymphocyte               39 (78%)     39 (78%)     42 (84%)     40 (80%)     44 (88%)                  
      Inflammation                                     2 (4%)                                 2 (4%)       1 (2%)                   
      Metaplasia, Osseous                              2 (4%)                    1 (2%)       3 (6%)       2 (4%)                   
      Mineralization                                  42 (84%)     44 (88%)     49 (98%)     45 (90%)     46 (92%)                  
      Nephropathy                                     46 (92%)     47 (94%)     46 (92%)     38 (76%)     42 (84%)                  
      Artery, Inflammation                                          1 (2%)                    1 (2%)                                
      Glomerulus, Dilatation                                                     1 (2%)                                             
      Renal Tubule, Dilatation                         6 (12%)      7 (14%)      5 (10%)      8 (16%)      9 (18%)                  
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                    20 (40%)     16 (32%)     20 (40%)     18 (36%)     21 (42%)                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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