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TDMS Study 56111-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 12/11/02       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 10:51:11       
TEST TYPE:  CHRONIC                                                                                            PAGE:       1        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25020 Natural Death                                                                          
                                       25017 Scheduled Sacrifice                                                                    
                                       25021 Terminal Sacrifice                                                                     
                                       25007 Wrong Sex                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    UNTREATDCONTROL                                                               
                                       INCLUDE 002    UNTREATDCONTROL                                                               
                                       INCLUDE 005    .312%                                                                         
                                       INCLUDE 006    .312%                                                                         
                                       INCLUDE 007    .625%                                                                         
                                       INCLUDE 008    .625%                                                                         
                                       INCLUDE 009    1.25%                                                                         
                                       INCLUDE 010    1.25%                                                                         
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 12/11/02       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 10:51:11       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Heart                                                                              
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 12/11/02       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 10:51:11       
TEST TYPE:  CHRONIC                                                                                                                 
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  TRANS-CINNAMALDEHYDE                                                                            
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Lung                                   Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Skin                                   Hemangioma                                                                                   
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma or Hemangioma                                                                
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   TRANS-CINNAMALDEHYDE         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.43      2/48.13      0/44.02      1/49.55     |0/47.03      0/45.42      0/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         0.0%         2.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/44 (2%)    2/46 (4%)    0/39 (0%)    1/49 (2%)   |0/43 (0%)    0/37 (0%)    0/44 (0%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          728 (T)     |---          ---          ---          733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475N     P=0.516      P=0.524N     P=0.737N    |P=0.207      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.492N     P=0.512      P=0.511N     P=0.746N    |P=0.199      (e)          (e)          P=0.498      | 
|POLY 1.5           |     P=0.493N     P=0.509      P=0.506N     P=0.749N    |P=0.198      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.491N     P=0.515      P=0.516N     P=0.743N    |P=0.202      (e)          (e)          P=0.499      | 
|LOGISTIC REGRESSION|     P=0.475N     P=0.516      (e)          P=0.737N    |(e)          (e)          (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.496N     P=0.508      P=0.500N     P=0.747N    |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.376N     (e)          (e)          (e)         |P=0.118      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    3/50 (6%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.45      3/48.13      1/44.90      2/49.55     |1/47.03      3/45.79      3/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     8.6%         6.2%         2.2%         4.0%        |2.1%         6.6%         6.3%         0.0%         | 
|TERMINAL (d)       |     4/44 (9%)    3/46 (7%)    1/39 (3%)    2/49 (4%)   |1/43 (2%)    2/37 (5%)    3/44 (7%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      628          733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198N     P=0.476N     P=0.218N     P=0.289N    |P=0.268N     P=0.264      P=0.314      P=0.500N     | 
|POLY 3             |     P=0.212N     P=0.481N     P=0.189N     P=0.308N    |P=0.282N     P=0.296      P=0.311      P=0.502N     | 
|POLY 1.5           |     P=0.214N     P=0.488N     P=0.183N     P=0.316N    |P=0.284N     P=0.300      P=0.309      P=0.502N     | 
|POLY 6             |     P=0.211N     P=0.477N     P=0.199N     P=0.302N    |P=0.278N     P=0.291      P=0.315      P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.198N     P=0.476N     P=0.218N     P=0.289N    |P=0.279N     P=0.306      P=0.314      (e)          | 
|COCH-ARM / FISHERS |     P=0.221N     P=0.500N     P=0.181N     P=0.339N    |P=0.279N     P=0.309      P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.181N     (e)          (e)          (e)         |P=0.157N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      1/48.13      0/44.90      0/49.55     |1/47.03      1/45.42      2/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |2.1%         2.2%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |1/43 (2%)    1/37 (3%)    2/44 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          728 (T)      ---          ---         |733 (T)      733 (T)      733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553N     P=0.509      (e)          (e)         |P=0.353N     P=0.728      P=0.508      P=0.500N     | 
|POLY 3             |     P=0.562N     P=0.507      (e)          (e)         |P=0.367N     P=0.753      P=0.506      P=0.502N     | 
|POLY 1.5           |     P=0.563N     P=0.505      (e)          (e)         |P=0.369N     P=0.756      P=0.503      P=0.502N     | 
|POLY 6             |     P=0.561N     P=0.509      (e)          (e)         |P=0.362N     P=0.749      P=0.509      P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          P=0.509      (e)          (e)         |P=0.353N     P=0.728      P=0.508      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.376N     (e)          (e)          (e)         |P=0.272N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    4/50 (8%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.45      3/48.13      1/44.90      2/49.55     |2/47.03      4/45.79      5/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     8.6%         6.2%         2.2%         4.0%        |4.3%         8.7%         10.5%        0.0%         | 
|TERMINAL (d)       |     4/44 (9%)    3/46 (7%)    1/39 (3%)    2/49 (4%)   |2/43 (5%)    3/37 (8%)    5/44 (11%)   0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      728 (T)      728 (T)     |733 (T)      628          733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198N     P=0.476N     P=0.218N     P=0.289N    |P=0.174N     P=0.280      P=0.226      P=0.238N     | 
|POLY 3             |     P=0.212N     P=0.481N     P=0.189N     P=0.308N    |P=0.188N     P=0.325      P=0.223      P=0.240N     | 
|POLY 1.5           |     P=0.214N     P=0.488N     P=0.183N     P=0.316N    |P=0.190N     P=0.330      P=0.221      P=0.240N     | 
|POLY 6             |     P=0.211N     P=0.477N     P=0.199N     P=0.302N    |P=0.182N     P=0.319      P=0.227      P=0.238N     | 
|LOGISTIC REGRESSION|     P=0.198N     P=0.476N     P=0.218N     P=0.289N    |P=0.184N     P=0.328      P=0.226      (e)          | 
|COCH-ARM / FISHERS |     P=0.221N     P=0.500N     P=0.181N     P=0.339N    |P=0.186N     P=0.339      P=0.218      P=0.247N     | 
|ORDER RESTRICTED   |     P=0.181N     (e)          (e)          (e)         |P=0.079N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   5/50 (10%)   4/50 (8%)   |4/50 (8%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/47.13      5/48.13      5/46.06      4/49.55     |4/47.03      4/45.52      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     10.6%        10.4%        10.9%        8.1%        |8.5%         8.8%         4.2%         2.2%         | 
|TERMINAL (d)       |     4/44 (9%)    5/46 (11%)   3/39 (8%)    4/49 (8%)   |4/43 (9%)    3/37 (8%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     498          728 (T)      498          728 (T)     |733 (T)      708          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.371N     P=0.603N     P=0.574      P=0.438N    |P=0.087N     P=0.564      P=0.326N     P=0.180N     | 
|POLY 3             |     P=0.392N     P=0.617N     P=0.615      P=0.469N    |P=0.095N     P=0.625      P=0.330N     P=0.182N     | 
|POLY 1.5           |     P=0.398N     P=0.621N     P=0.626      P=0.476N    |P=0.096N     P=0.632      P=0.333N     P=0.183N     | 
|POLY 6             |     P=0.387N     P=0.615N     P=0.601      P=0.463N    |P=0.092N     P=0.616      P=0.325N     P=0.180N     | 
|LOGISTIC REGRESSION|     P=0.444N     P=0.630N     P=0.628      P=0.530N    |P=0.087N     P=0.603      P=0.326N     P=0.180N     | 
|COCH-ARM / FISHERS |     P=0.419N     P=0.630N     P=0.630N     P=0.500N    |P=0.095N     P=0.643N     P=0.339N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.532N     (e)          (e)          (e)         |P=0.141N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   4/50 (8%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/47.28      7/48.13      4/46.06      3/49.55     |1/47.03      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     12.7%        14.5%        8.7%         6.1%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/44 (9%)    7/46 (15%)   2/39 (5%)    3/49 (6%)   |1/43 (2%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     538          728 (T)      498          728 (T)     |733 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114N     P=0.532      P=0.429N     P=0.202N    |P=0.301N     P=0.530N     P=0.495N     P=0.500N     | 
|POLY 3             |     P=0.118N     P=0.514      P=0.386N     P=0.220N    |P=0.301N     P=0.507N     P=0.497N     P=0.502N     | 
|POLY 1.5           |     P=0.121N     P=0.510      P=0.375N     P=0.225N    |P=0.302N     P=0.504N     P=0.498N     P=0.502N     | 
|POLY 6             |     P=0.117N     P=0.512      P=0.404N     P=0.218N    |P=0.299N     P=0.511N     P=0.495N     P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.143N     P=0.504      P=0.372N     P=0.266N    |P=0.301N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.132N     P=0.500      P=0.370N     P=0.243N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.172N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  12/50 (24%)  7/50 (14%)   7/50 (14%)  |4/50 (8%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/47.96     12/48.13     7/46.06      7/49.55     |4/47.03      4/45.52      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     20.9%        24.9%        15.2%        14.1%       |8.5%         8.8%         4.2%         2.2%         | 
|TERMINAL (d)       |     7/44 (16%)   12/46 (26%)  5/39 (13%)   7/49 (14%)  |4/43 (9%)    3/37 (8%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     498          728 (T)      498          728 (T)     |733 (T)      708          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126N     P=0.450      P=0.379N     P=0.232N    |P=0.087N     P=0.564      P=0.326N     P=0.180N     | 
|POLY 3             |     P=0.144N     P=0.408      P=0.329N     P=0.273N    |P=0.095N     P=0.625      P=0.330N     P=0.182N     | 
|POLY 1.5           |     P=0.145N     P=0.408      P=0.311N     P=0.276N    |P=0.096N     P=0.632      P=0.333N     P=0.183N     | 
|POLY 6             |     P=0.144N     P=0.402      P=0.356N     P=0.273N    |P=0.092N     P=0.616      P=0.325N     P=0.180N     | 
|LOGISTIC REGRESSION|     P=0.164N     P=0.407      P=0.295N     P=0.343N    |P=0.087N     P=0.603      P=0.326N     P=0.180N     | 
|COCH-ARM / FISHERS |     P=0.160N     P=0.405      P=0.298N     P=0.298N    |P=0.095N     P=0.643N     P=0.339N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.208N     (e)          (e)          (e)         |P=0.141N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  12/50 (24%)  7/50 (14%)   7/50 (14%)  |4/50 (8%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     10/47.96     12/48.13     7/46.06      7/49.55     |4/47.03      4/45.52      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     20.9%        24.9%        15.2%        14.1%       |8.5%         8.8%         4.2%         2.2%         | 
|TERMINAL (d)       |     7/44 (16%)   12/46 (26%)  5/39 (13%)   7/49 (14%)  |4/43 (9%)    3/37 (8%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     498          728 (T)      498          728 (T)     |733 (T)      708          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126N     P=0.450      P=0.379N     P=0.232N    |P=0.087N     P=0.564      P=0.326N     P=0.180N     | 
|POLY 3             |     P=0.144N     P=0.408      P=0.329N     P=0.273N    |P=0.095N     P=0.625      P=0.330N     P=0.182N     | 
|POLY 1.5           |     P=0.145N     P=0.408      P=0.311N     P=0.276N    |P=0.096N     P=0.632      P=0.333N     P=0.183N     | 
|POLY 6             |     P=0.144N     P=0.402      P=0.356N     P=0.273N    |P=0.092N     P=0.616      P=0.325N     P=0.180N     | 
|LOGISTIC REGRESSION|     P=0.164N     P=0.407      P=0.295N     P=0.343N    |P=0.087N     P=0.603      P=0.326N     P=0.180N     | 
|COCH-ARM / FISHERS |     P=0.160N     P=0.405      P=0.298N     P=0.298N    |P=0.095N     P=0.643N     P=0.339N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.208N     (e)          (e)          (e)         |P=0.141N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    7/50 (14%)   2/50 (4%)    7/50 (14%)  |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.45      7/48.44      2/45.02      7/49.55     |1/47.03      1/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     6.5%         14.5%        4.4%         14.1%       |2.1%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/44 (7%)    6/46 (13%)   1/39 (3%)    7/49 (14%)  |1/43 (2%)    1/37 (3%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      644          699          728 (T)     |733 (T)      733 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.271      P=0.180      P=0.550N     P=0.206     |P=0.230N     P=0.728      P=0.495N     P=0.500N     | 
|POLY 3             |     P=0.245      P=0.176      P=0.514N     P=0.186     |P=0.235N     P=0.753      P=0.497N     P=0.502N     | 
|POLY 1.5           |     P=0.238      P=0.169      P=0.505N     P=0.178     |P=0.236N     P=0.756      P=0.498N     P=0.502N     | 
|POLY 6             |     P=0.249      P=0.181      P=0.527N     P=0.192     |P=0.235N     P=0.749      P=0.495N     P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.248      P=0.168      P=0.528N     P=0.206     |P=0.230N     P=0.728      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.220      P=0.159      P=0.500N     P=0.159     |P=0.235N     P=0.753N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.160      (e)          (e)          (e)         |P=0.247N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    6/50 (12%)  |2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.45      1/48.13      2/45.30      6/50.00     |2/47.03      2/45.44      1/48.34      1/46.74      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         4.4%         12.0%       |4.3%         4.4%         2.1%         2.1%         | 
|TERMINAL (d)       |     2/44 (5%)    1/46 (2%)    0/39 (0%)    5/49 (10%)  |2/43 (5%)    1/37 (3%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      652          596         |733 (T)      728          568          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.048 *    P=0.484N     P=0.658      P=0.173     |P=0.324N     P=0.641      P=0.492N     P=0.495N     | 
|POLY 3             |     P=0.037 *    P=0.488N     P=0.685      P=0.159     |P=0.335N     P=0.681      P=0.490N     P=0.502N     | 
|POLY 1.5           |     P=0.036 *    P=0.492N     P=0.691      P=0.152     |P=0.338N     P=0.686      P=0.495N     P=0.504N     | 
|POLY 6             |     P=0.038 *    P=0.485N     P=0.677      P=0.166     |P=0.330N     P=0.675      P=0.485N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.032 *    P=0.484N     P=0.694      P=0.129     |P=0.329N     P=0.663      P=0.515N     P=0.502N     | 
|COCH-ARM / FISHERS |     P=0.033 *    P=0.500N     P=0.691N     P=0.134     |P=0.337N     P=0.691N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.042 *    (e)          (e)          (e)         |P=0.430N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   3/50 (6%)    13/50 (26%) |3/50 (6%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/46.45      8/48.44      3/45.30      13/50.00    |3/47.03      3/45.44      1/48.34      1/46.74      | 
|POLY-3 PERCENT (g) |     8.6%         16.5%        6.6%         26.0%       |6.4%         6.6%         2.1%         2.1%         | 
|TERMINAL (d)       |     4/44 (9%)    7/46 (15%)   1/39 (3%)    12/49 (25%) |3/43 (7%)    2/37 (5%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      644          652          596         |733 (T)      728          568          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026 *    P=0.202      P=0.557N     P=0.030 *   |P=0.157N     P=0.593      P=0.299N     P=0.303N     | 
|POLY 3             |     P=0.016 *    P=0.199      P=0.514N     P=0.023 *   |P=0.163N     P=0.646      P=0.296N     P=0.308N     | 
|POLY 1.5           |     P=0.015 *    P=0.191      P=0.504N     P=0.020 *   |P=0.165N     P=0.652      P=0.300N     P=0.309N     | 
|POLY 6             |     P=0.017 *    P=0.205      P=0.526N     P=0.025 *   |P=0.159N     P=0.638      P=0.290N     P=0.303N     | 
|LOGISTIC REGRESSION|     P=0.017 *    P=0.191      P=0.513N     P=0.020 *   |P=0.163N     P=0.619      P=0.315N     P=0.308N     | 
|COCH-ARM / FISHERS |     P=0.014 *    P=0.178      P=0.500N     P=0.016 *   |P=0.164N     P=0.661N     P=0.309N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |P=0.234N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      0/48.13      0/44.90      0/49.55     |0/47.03      0/45.42      2/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/43 (0%)    0/37 (0%)    2/44 (5%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.604      (e)          P=0.244      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.593      (e)          P=0.241      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.590      (e)          P=0.239      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.600      (e)          P=0.243      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.244      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.251      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/47.25      2/45.52      1/46.83      1/46.54      | 
|POLY-3 PERCENT (g) |                                                        |4.2%         4.4%         2.1%         2.2%         | 
|TERMINAL (d)       |                                                        |1/43 (2%)    1/37 (3%)    1/44 (2%)    1/43 (2%)    | 
|FIRST INCIDENCE    |                                                        |675          708          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.322N     P=0.650      P=0.490N     P=0.497N     | 
|POLY 3             |                                                        |P=0.339N     P=0.680      P=0.503N     P=0.505N     | 
|POLY 1.5           |                                                        |P=0.341N     P=0.686      P=0.505N     P=0.505N     | 
|POLY 6             |                                                        |P=0.336N     P=0.673      P=0.501N     P=0.504N     | 
|LOGISTIC REGRESSION|                                                        |P=0.338N     P=0.692      P=0.509N     P=0.502N     | 
|COCH-ARM / FISHERS |                                                        |P=0.338N     P=0.691N     P=0.508N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.438N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |5/48 (10%)   1/50 (2%)    4/49 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.05      0/47.13      0/44.90      0/48.55     |5/45.70      1/45.94      4/46.80      2/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |10.9%        2.2%         8.6%         4.3%         | 
|TERMINAL (d)       |     0/43 (0%)    0/45 (0%)    0/39 (0%)    0/48 (0%)   |4/42 (10%)   0/37 (0%)    4/43 (9%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |652          575          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.253N     P=0.130N     P=0.487N     P=0.212N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.259N     P=0.100N     P=0.485N     P=0.209N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.262N     P=0.097N     P=0.486N     P=0.208N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.254N     P=0.105N     P=0.485N     P=0.209N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.261N     P=0.083N     P=0.482N     P=0.205N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.260N     P=0.093N     P=0.487N     P=0.201N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.151N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      0/48.13      0/44.90      0/49.55     |2/47.03      3/45.66      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         6.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |2/43 (5%)    2/37 (5%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |733 (T)      668          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.070N     P=0.442      P=0.233N     P=0.238N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.072N     P=0.487      P=0.234N     P=0.240N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.072N     P=0.492      P=0.235N     P=0.240N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.071N     P=0.480      P=0.232N     P=0.238N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.073N     P=0.485      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.073N     P=0.500      P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.45      0/48.13      0/44.90      0/49.55     |0/47.03      0/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/44 (5%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/43 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113N     P=0.229N     P=0.265N     P=0.215N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.119N     P=0.229N     P=0.245N     P=0.223N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.117N     P=0.232N     P=0.240N     P=0.227N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.121N     P=0.228N     P=0.252N     P=0.220N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.113N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.025N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.45      1/48.13      0/44.51      0/49.55     |0/45.75      0/45.42      2/47.80      1/46.54      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         0.0%        |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     1/44 (2%)    1/46 (2%)    0/39 (0%)    0/49 (0%)   |0/43 (0%)    0/37 (0%)    2/44 (5%)    1/43 (2%)    | 
|FIRST INCIDENCE    |     728 (T)      728 (T)      ---          ---         |---          ---          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.228N     P=0.752N     P=0.524N     P=0.479N    |P=0.259      (e)          P=0.244      P=0.500      | 
|POLY 3             |     P=0.236N     P=0.753N     P=0.508N     P=0.487N    |P=0.248      (e)          P=0.247      P=0.503      | 
|POLY 1.5           |     P=0.236N     P=0.755N     P=0.505N     P=0.491N    |P=0.247      (e)          P=0.247      P=0.504      | 
|POLY 6             |     P=0.236N     P=0.751N     P=0.513N     P=0.484N    |P=0.251      (e)          P=0.247      P=0.503      | 
|LOGISTIC REGRESSION|     P=0.228N     P=0.752N     (e)          (e)         |(e)          (e)          P=0.244      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.505N     P=0.500N    |P=0.252      (e)          P=0.258      P=0.510      | 
|ORDER RESTRICTED   |     P=0.239N     (e)          (e)          (e)         |P=0.176      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      0/48.13      2/45.01      1/49.55     |1/47.03      0/45.42      4/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         2.0%        |2.1%         0.0%         8.4%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/46 (0%)    1/39 (3%)    1/49 (2%)   |1/43 (2%)    0/37 (0%)    4/44 (9%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          702          728 (T)     |733 (T)      ---          733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.270      (e)          P=0.216      P=0.521     |P=0.513N     P=0.530N     P=0.187      P=0.500N     | 
|POLY 3             |     P=0.268      (e)          P=0.230      P=0.513     |P=0.530N     P=0.507N     P=0.184      P=0.502N     | 
|POLY 1.5           |     P=0.262      (e)          P=0.235      P=0.509     |P=0.534N     P=0.504N     P=0.182      P=0.502N     | 
|POLY 6             |     P=0.274      (e)          P=0.224      P=0.516     |P=0.521N     P=0.511N     P=0.187      P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.256      (e)          P=0.230      P=0.521     |P=0.513N     (e)          P=0.187      (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.531N     P=0.500N     P=0.181      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.163      (e)          (e)          (e)         |P=0.219N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      0/48.13      1/44.90      1/49.55     |1/47.03      0/45.42      3/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.0%        |2.1%         0.0%         6.3%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/46 (0%)    1/39 (3%)    1/49 (2%)   |1/43 (2%)    0/37 (0%)    3/44 (7%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          728 (T)      728 (T)     |733 (T)      ---          733 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256      (e)          P=0.476      P=0.521     |P=0.485N     P=0.530N     P=0.314      P=0.500N     | 
|POLY 3             |     P=0.253      (e)          P=0.493      P=0.513     |P=0.498N     P=0.507N     P=0.311      P=0.502N     | 
|POLY 1.5           |     P=0.249      (e)          P=0.497      P=0.509     |P=0.502N     P=0.504N     P=0.309      P=0.502N     | 
|POLY 6             |     P=0.257      (e)          P=0.487      P=0.516     |P=0.491N     P=0.511N     P=0.315      P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.476      P=0.521     |P=0.485N     (e)          P=0.314      (e)          | 
|COCH-ARM / FISHERS |     P=0.235      (e)          P=0.500      P=0.500     |P=0.500N     P=0.500N     P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.246      (e)          (e)          (e)         |P=0.268N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.45      0/48.13      0/44.90      0/49.55     |2/47.03      1/45.42      0/47.80      0/46.54      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |4.3%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/44 (5%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |2/43 (5%)    1/37 (3%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     728 (T)      ---          ---          ---         |733 (T)      733 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113N     P=0.229N     P=0.265N     P=0.215N    |P=0.097N     P=0.552N     P=0.233N     P=0.238N     | 
|POLY 3             |     P=0.119N     P=0.229N     P=0.245N     P=0.223N    |P=0.099N     P=0.512N     P=0.234N     P=0.240N     | 
|POLY 1.5           |     P=0.117N     P=0.232N     P=0.240N     P=0.227N    |P=0.100N     P=0.507N     P=0.235N     P=0.240N     | 
|POLY 6             |     P=0.121N     P=0.228N     P=0.252N     P=0.220N    |P=0.098N     P=0.519N     P=0.232N     P=0.238N     | 
|LOGISTIC REGRESSION|     P=0.113N     (e)          (e)          (e)         |P=0.097N     P=0.552N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.101N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.025N*    (e)          (e)          (e)         |P=0.076N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.45      2/48.44      1/44.90      0/49.55     |0/47.03      0/45.42      3/47.80      2/46.54      | 
|POLY-3 PERCENT (g) |     2.2%         4.1%         2.2%         0.0%        |0.0%         0.0%         6.3%         4.3%         | 
|TERMINAL (d)       |     1/44 (2%)    1/46 (2%)    1/39 (3%)    0/49 (0%)   |0/43 (0%)    0/37 (0%)    3/44 (7%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     728 (T)      644          728 (T)      ---         |---          ---          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.236N     P=0.515      P=0.735      P=0.479N    |P=0.107      (e)          P=0.125      P=0.238      | 
|POLY 3             |     P=0.234N     P=0.515      P=0.753      P=0.487N    |P=0.095      (e)          P=0.122      P=0.235      | 
|POLY 1.5           |     P=0.238N     P=0.509      P=0.758      P=0.491N    |P=0.094      (e)          P=0.121      P=0.235      | 
|POLY 6             |     P=0.232N     P=0.519      P=0.746      P=0.484N    |P=0.099      (e)          P=0.124      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.499      P=0.735      (e)         |(e)          (e)          P=0.125      P=0.238      | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |P=0.096      (e)          P=0.121      P=0.247      | 
|ORDER RESTRICTED   |     P=0.221N     (e)          (e)          (e)         |P=0.083      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/46.45      2/48.44      1/44.90      0/49.55     |2/47.03      1/45.42      3/47.80      2/46.54      | 
|POLY-3 PERCENT (g) |     6.5%         4.1%         2.2%         0.0%        |4.3%         2.2%         6.3%         4.3%         | 
|TERMINAL (d)       |     3/44 (7%)    1/46 (2%)    1/39 (3%)    0/49 (0%)   |2/43 (5%)    1/37 (3%)    3/44 (7%)    2/43 (5%)    | 
|FIRST INCIDENCE    |     728 (T)      644          728 (T)      ---         |733 (T)      733 (T)      733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.059N     P=0.480N     P=0.349N     P=0.103N    |P=0.522      P=0.552N     P=0.511      P=0.695      | 
|POLY 3             |     P=0.058N     P=0.481N     P=0.318N     P=0.108N    |P=0.502      P=0.512N     P=0.507      P=0.690      | 
|POLY 1.5           |     P=0.059N     P=0.488N     P=0.310N     P=0.111N    |P=0.498      P=0.507N     P=0.504      P=0.689      | 
|POLY 6             |     P=0.058N     P=0.476N     P=0.328N     P=0.106N    |P=0.510      P=0.519N     P=0.512      P=0.693      | 
|LOGISTIC REGRESSION|     P=0.059N     P=0.496N     P=0.349N     (e)         |P=0.522      P=0.552N     P=0.511      P=0.695      | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.500N     P=0.309N     P=0.121N    |P=0.500      P=0.500N     P=0.500      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.049N*    (e)          (e)          (e)         |P=0.493      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.45      1/48.24      2/45.72      0/49.55     |0/47.03      1/45.98      1/48.13      0/46.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         4.4%         0.0%        |0.0%         2.2%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/46 (0%)    0/39 (0%)    0/49 (0%)   |0/43 (0%)    0/37 (0%)    0/44 (0%)    0/43 (0%)    | 
|FIRST INCIDENCE    |     ---          701          566          ---         |---          558          642          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.597N     P=0.513      P=0.230      (e)         |P=0.595N     P=0.500      P=0.504      (e)          | 
|POLY 3             |     P=0.592N     P=0.508      P=0.234      (e)         |P=0.597N     P=0.495      P=0.505      (e)          | 
|POLY 1.5           |     P=0.598N     P=0.505      P=0.237      (e)         |P=0.597N     P=0.497      P=0.503      (e)          | 
|POLY 6             |     P=0.586N     P=0.509      P=0.230      (e)         |P=0.594N     P=0.493      P=0.507      (e)          | 
|LOGISTIC REGRESSION|     P=0.642      P=0.499      P=0.209      (e)         |P=0.516N     P=0.588      P=0.487      (e)          | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.500      P=0.247      (e)         |P=0.595N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.316N     (e)          (e)          (e)         |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |13/50 (26%)  6/50 (12%)   8/50 (16%)   14/50 (28%)  | 
|POLY-3 RATE (b)    |     4/47.05      1/48.13      2/45.73      2/49.55     |13/47.03     6/45.46      8/49.11      14/47.59     | 
|POLY-3 PERCENT (g) |     8.5%         2.1%         4.4%         4.0%        |27.6%        13.2%        16.3%        29.4%        | 
|TERMINAL (d)       |     3/44 (7%)    1/46 (2%)    0/39 (0%)    2/49 (4%)   |13/43 (30%)  5/37 (14%)   5/44 (11%)   11/43 (26%)  | 
|FIRST INCIDENCE    |     538          728 (T)      561          728 (T)     |733 (T)      723          425          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.169N     P=0.375N     P=0.294N    |P=0.315      P=0.118N     P=0.154N     P=0.500      | 
|POLY 3             |     P=0.335N     P=0.172N     P=0.351N     P=0.314N    |P=0.292      P=0.070N     P=0.135N     P=0.514      | 
|POLY 1.5           |     P=0.336N     P=0.175N     P=0.342N     P=0.320N    |P=0.277      P=0.067N     P=0.146N     P=0.500      | 
|POLY 6             |     P=0.333N     P=0.172N     P=0.362N     P=0.310N    |P=0.317      P=0.075N     P=0.123N     P=0.538      | 
|LOGISTIC REGRESSION|     P=0.381N     P=0.183N     P=0.344N     P=0.369N    |P=0.265      P=0.093N     P=0.167N     P=0.488      | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.181N     P=0.339N     P=0.339N    |P=0.267      P=0.062N     P=0.163N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.190N     (e)          (e)          (e)         |P=0.169      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  16/50 (32%)  9/50 (18%)   15/50 (30%) |17/50 (34%)  10/50 (20%)  14/50 (28%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     14/47.13     16/48.44     9/46.17      15/49.55    |17/47.55     10/46.96     14/47.80     7/46.54      | 
|POLY-3 PERCENT (g) |     29.7%        33.0%        19.5%        30.3%       |35.8%        21.3%        29.3%        15.0%        | 
|TERMINAL (d)       |     13/44 (30%)  15/46 (33%)  6/39 (15%)   15/49 (31%) |15/43 (35%)  6/37 (16%)   14/44 (32%)  7/43 (16%)   | 
|FIRST INCIDENCE    |     498          644          498          728 (T)     |652          558          733 (T)      733 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419N     P=0.470      P=0.258N     P=0.541N    |P=0.023N*    P=0.178N     P=0.306N     P=0.018N*    | 
|POLY 3             |     P=0.477N     P=0.449      P=0.183N     P=0.563     |P=0.029N*    P=0.090N     P=0.325N     P=0.017N*    | 
|POLY 1.5           |     P=0.485N     P=0.435      P=0.173N     P=0.548     |P=0.030N*    P=0.089N     P=0.328N     P=0.017N*    | 
|POLY 6             |     P=0.471N     P=0.458      P=0.198N     P=0.575     |P=0.028N*    P=0.093N     P=0.323N     P=0.017N*    | 
|LOGISTIC REGRESSION|     P=0.487N     P=0.439      P=0.172N     P=0.552     |P=0.028N*    P=0.090N     P=0.300N     P=0.017N*    | 
|COCH-ARM / FISHERS |     P=0.521N     P=0.414      P=0.171N     P=0.500     |P=0.029N*    P=0.088N     P=0.333N     P=0.017N*    | 
|ORDER RESTRICTED   |     P=0.389N     (e)          (e)          (e)         |P=0.013N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  14/50 (28%)  11/50 (22%)  12/50 (24%) |24/50 (48%)  13/50 (26%)  16/50 (32%)  16/50 (32%)  | 
|POLY-3 RATE (b)    |     12/47.28     14/48.54     11/47.91     12/50.00    |24/48.84     13/46.65     16/50.00     16/47.79     | 
|POLY-3 PERCENT (g) |     25.4%        28.8%        23.0%        24.0%       |49.1%        27.9%        32.0%        33.5%        | 
|TERMINAL (d)       |     10/44 (23%)  12/46 (26%)  3/39 (8%)    11/49 (22%) |20/43 (47%)  8/37 (22%)   10/44 (23%)  12/43 (28%)  | 
|FIRST INCIDENCE    |     538          644          498          596         |429          558          425          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.383N     P=0.463      P=0.584      P=0.479N    |P=0.131N     P=0.072N     P=0.087N     P=0.096N     | 
|POLY 3             |     P=0.408N     P=0.440      P=0.486N     P=0.531N    |P=0.133N     P=0.025N*    P=0.062N     P=0.086N     | 
|POLY 1.5           |     P=0.421N     P=0.430      P=0.485N     P=0.546N    |P=0.140N     P=0.022N*    P=0.067N     P=0.086N     | 
|POLY 6             |     P=0.399N     P=0.446      P=0.488N     P=0.520N    |P=0.121N     P=0.029N*    P=0.055N     P=0.083N     | 
|LOGISTIC REGRESSION|     P=0.499N     P=0.425      P=0.495N     P=0.593     |P=0.134N     P=0.018N*    P=0.089N     P=0.075N     | 
|COCH-ARM / FISHERS |     P=0.467N     P=0.410      P=0.500N     P=0.592N    |P=0.140N     P=0.019N*    P=0.076N     P=0.076N     | 
|ORDER RESTRICTED   |     P=0.534N     (e)          (e)          (e)         |P=0.044N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/11/02                           EXPERIMENT: 56111 TEST: 04                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   TRANS-CINNAMALDEHYDE          
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     UNTREATD     .312%        .625%        1.25%       |UNTREATD     .312%        .625%        1.25%        | 
|                   |     CONTROL                                            |CONTROL                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  27/50 (54%)  17/50 (34%)  22/50 (44%) |33/50 (66%)  21/50 (42%)  24/50 (48%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     23/47.96     27/48.54     17/47.91     22/50.00    |33/49.36     21/47.27     24/50.00     21/47.79     | 
|POLY-3 PERCENT (g) |     48.0%        55.6%        35.5%        44.0%       |66.9%        44.4%        48.0%        43.9%        | 
|TERMINAL (d)       |     20/44 (46%)  25/46 (54%)  9/39 (23%)   21/49 (43%) |27/43 (63%)  14/37 (38%)  18/44 (41%)  17/43 (40%)  | 
|FIRST INCIDENCE    |     498          644          498          596         |429          558          425          568          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197N     P=0.359      P=0.290N     P=0.327N    |P=0.036N*    P=0.095N     P=0.069N     P=0.026N*    | 
|POLY 3             |     P=0.231N     P=0.292      P=0.151N     P=0.425N    |P=0.034N*    P=0.019N*    P=0.043N*    P=0.017N*    | 
|POLY 1.5           |     P=0.241N     P=0.286      P=0.146N     P=0.440N    |P=0.035N*    P=0.016N*    P=0.046N*    P=0.016N*    | 
|POLY 6             |     P=0.224N     P=0.292      P=0.158N     P=0.416N    |P=0.031N*    P=0.025N*    P=0.041N*    P=0.018N*    | 
|LOGISTIC REGRESSION|     P=0.275N     P=0.300      P=0.152N     P=0.480N    |P=0.032N*    P=0.014N*    P=0.061N     P=0.014N*    | 
|COCH-ARM / FISHERS |     P=0.290N     P=0.274      P=0.154N     P=0.500N    |P=0.033N*    P=0.013N*    P=0.053N     P=0.013N*    | 
|ORDER RESTRICTED   |     P=0.179N     (e)          (e)          (e)         |P=0.014N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).