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TDMS Study 56111-04 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                    TRANS-CINNAMALDEHYDE                                 DATE: 06/14/01       
EXPERIMENT: 56111 TEST: 04                                                                                     TIME: 09:43:36       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55384                              ROUTE: DOSED FEED                                              NTP C#: 56111B       
PATHOLOGIST: MARIT, GARY                                                                                       CAS: 14371-10-9      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  TRANS-CINNAMALDEHYDE                                                                            
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney                                 Infiltration Cellular Lymphocyte                                                             
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Mesentery: Fat                         Necrosis                                                                                     
Uterus                                 Inflammation                                                                                 
===============================================================                                                                     
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)    |           2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/46.43                  0/48.41      |           2/47.03                  1/46.19         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           4.3%                     2.2%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           2/43 (5%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  698             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.511N        | 
|POLY 3             |                                           (e)          |                                    P=0.508N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.506N        | 
|POLY 6             |                                           (e)          |                                    P=0.509N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.506N        | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)    |           2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/46.43                  0/48.41      |           2/47.03                  2/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           4.3%                     4.3%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           2/43 (5%)                2/41 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.678         | 
|POLY 3             |                                           (e)          |                                    P=0.688         | 
|POLY 1.5           |                                           (e)          |                                    P=0.690         | 
|POLY 6             |                                           (e)          |                                    P=0.687         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.678         | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.691N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  23/49 (47%)              23/50 (46%)  |           4/50 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  23/46.43                 23/48.41     |           4/47.03                  4/46.06         | 
|POLY-3 PERCENT (g) |                  49.5%                    47.5%        |           8.5%                     8.7%            | 
|TERMINAL (d)       |                  23/44 (52%)              23/47 (49%)  |           4/43 (9%)                4/41 (10%)      | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.457N     |                                    P=0.618         | 
|POLY 3             |                                           P=0.502N     |                                    P=0.633         | 
|POLY 1.5           |                                           P=0.526N     |                                    P=0.636         | 
|POLY 6             |                                           P=0.479N     |                                    P=0.631         | 
|LOGISTIC REGRESSION|                                           P=0.457N     |                                    P=0.618         | 
|COCH-ARM / FISHERS |                                           P=0.543N     |                                    P=0.643N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)    |           32/50 (64%)              34/50 (68%)     | 
|POLY-3 RATE (b)    |                  0/46.43                  0/48.41      |           32/47.97                 34/46.48        | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           66.7%                    73.2%           | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           30/43 (70%)              33/41 (81%)     | 
|FIRST INCIDENCE    |                  ---                      ---          |           520                      609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.278         | 
|POLY 3             |                                           (e)          |                                    P=0.321         | 
|POLY 1.5           |                                           (e)          |                                    P=0.355         | 
|POLY 6             |                                           (e)          |                                    P=0.295         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.334         | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.417         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)    |           36/50 (72%)              34/50 (68%)     | 
|POLY-3 RATE (b)    |                  0/46.43                  0/48.41      |           36/47.33                 34/46.19        | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           76.1%                    73.6%           | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           35/43 (81%)              33/41 (81%)     | 
|FIRST INCIDENCE    |                  ---                      ---          |           652                      698             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.566N        | 
|POLY 3             |                                           (e)          |                                    P=0.486N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.459N        | 
|POLY 6             |                                           (e)          |                                    P=0.507N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.456N        | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.414N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  39/49 (80%)              46/50 (92%)  |           50/50 (100%)             49/50 (98%)     | 
|POLY-3 RATE (b)    |                  39/47.94                 46/50.00     |           50/50.00                 49/49.24        | 
|POLY-3 PERCENT (g) |                  81.4%                    92.0%        |           100.0%                   99.5%           | 
|TERMINAL (d)       |                  36/44 (82%)              43/47 (92%)  |           43/43 (100%)             41/41 (100%)    | 
|FIRST INCIDENCE    |                  498                      100          |           429                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.211      |                                    P=0.479         | 
|POLY 3             |                                           P=0.101      |                                    P=0.999N        | 
|POLY 1.5           |                                           P=0.089      |                                    P=0.850N        | 
|POLY 6             |                                           P=0.110      |                                    P=1.000N        | 
|LOGISTIC REGRESSION|                                           P=0.069      |                                    P=0.581N        | 
|COCH-ARM / FISHERS |                                           P=0.068      |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/50 (0%)    |           3/49 (6%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/46.43                  0/48.41      |           3/46.25                  1/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           6.5%                     2.2%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           3/43 (7%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.322N        | 
|POLY 3             |                                           (e)          |                                    P=0.307N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.303N        | 
|POLY 6             |                                           (e)          |                                    P=0.310N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.322N        | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.301N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)    |           24/50 (48%)              27/50 (54%)     | 
|POLY-3 RATE (b)    |                  1/46.45                  1/48.41      |           24/47.03                 27/46.62        | 
|POLY-3 PERCENT (g) |                  2.2%                     2.1%         |           51.0%                    57.9%           | 
|TERMINAL (d)       |                  1/44 (2%)                1/47 (2%)    |           24/43 (56%)              25/41 (61%)     | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.747N     |                                    P=0.251         | 
|POLY 3             |                                           P=0.747N     |                                    P=0.321         | 
|POLY 1.5           |                                           P=0.752N     |                                    P=0.326         | 
|POLY 6             |                                           P=0.743N     |                                    P=0.327         | 
|LOGISTIC REGRESSION|                                           P=0.747N     |                                    P=0.291         | 
|COCH-ARM / FISHERS |                                           P=0.753N     |                                    P=0.345         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  17/50 (34%)              14/50 (28%)  |           11/50 (22%)              10/50 (20%)     | 
|POLY-3 RATE (b)    |                  17/48.86                 14/49.92     |           11/49.20                 10/46.92        | 
|POLY-3 PERCENT (g) |                  34.8%                    28.0%        |           22.4%                    21.3%           | 
|TERMINAL (d)       |                  13/44 (30%)              12/47 (26%)  |           5/43 (12%)               7/41 (17%)      | 
|FIRST INCIDENCE    |                  340                      100          |           520                      609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.278N     |                                    P=0.545N        | 
|POLY 3             |                                           P=0.307N     |                                    P=0.551N        | 
|POLY 1.5           |                                           P=0.311N     |                                    P=0.531N        | 
|POLY 6             |                                           P=0.305N     |                                    P=0.572N        | 
|LOGISTIC REGRESSION|                                           P=0.395N     |                                    P=0.461N        | 
|COCH-ARM / FISHERS |                                           P=0.333N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Meninges                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           2/49 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/46.45                  0/48.41      |           2/46.41                  0/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           4.3%                     0.0%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           2/43 (5%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.249N        | 
|POLY 3             |                                           (e)          |                                    P=0.240N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.236N        | 
|POLY 6             |                                           (e)          |                                    P=0.243N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.242N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           33/50 (66%)              35/49 (71%)     | 
|POLY-3 RATE (b)    |                                                        |           33/49.36                 35/45.24        | 
|POLY-3 PERCENT (g) |                                                        |           66.9%                    77.4%           | 
|TERMINAL (d)       |                                                        |           28/43 (65%)              34/41 (83%)     | 
|FIRST INCIDENCE    |                                                        |           429                      693             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.295         | 
|POLY 3             |                                                        |                                    P=0.180         | 
|POLY 1.5           |                                                        |                                    P=0.241         | 
|POLY 6             |                                                        |                                    P=0.131         | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.295         | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.358         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |                                                    | 
|POLY-3 RATE (b)    |                  0/46.45                  3/48.41      |                                                    | 
|POLY-3 PERCENT (g) |                  0.0%                     6.2%         |                                                    | 
|TERMINAL (d)       |                  0/44 (0%)                3/47 (6%)    |                                                    | 
|FIRST INCIDENCE    |                  ---                      728 (T)      |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.133      |                                                    | 
|POLY 3             |                                           P=0.124      |                                                    | 
|POLY 1.5           |                                           P=0.122      |                                                    | 
|POLY 6             |                                           P=0.126      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.133      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.121      |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                2/50 (4%)    |           2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  4/49.01                  2/48.92      |           2/47.75                  1/46.82         | 
|POLY-3 PERCENT (g) |                  8.2%                     4.1%         |           4.2%                     2.1%            | 
|TERMINAL (d)       |                  1/44 (2%)                1/47 (2%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  188                      572          |           627                      456             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.327N     |                                    P=0.515N        | 
|POLY 3             |                                           P=0.339N     |                                    P=0.509N        | 
|POLY 1.5           |                                           P=0.342N     |                                    P=0.505N        | 
|POLY 6             |                                           P=0.333N     |                                    P=0.514N        | 
|LOGISTIC REGRESSION|                                           P=0.428N     |                                    P=0.390N        | 
|COCH-ARM / FISHERS |                                           P=0.339N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)    |           3/50 (6%)                6/50 (12%)      | 
|POLY-3 RATE (b)    |                  2/46.45                  4/48.41      |           3/47.03                  6/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     8.3%         |           6.4%                     13.0%           | 
|TERMINAL (d)       |                  2/44 (5%)                4/47 (9%)    |           3/43 (7%)                6/41 (15%)      | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.368      |                                    P=0.219         | 
|POLY 3             |                                           P=0.354      |                                    P=0.233         | 
|POLY 1.5           |                                           P=0.348      |                                    P=0.236         | 
|POLY 6             |                                           P=0.359      |                                    P=0.231         | 
|LOGISTIC REGRESSION|                                           P=0.368      |                                    P=0.219         | 
|COCH-ARM / FISHERS |                                           P=0.339      |                                    P=0.243         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/4 (25%)                0/4 (0%)     |           2/2 (100%)               0/1 (0%)        | 
|POLY-3 RATE (b)    |                  1/4.00                   0/4.00       |           2/2.00                   0/1.00          | 
|POLY-3 PERCENT (g) |                  25.0%                    0.0%         |           100.0%                   0.0%            | 
|TERMINAL (d)       |                  1/4 (25%)                0/4 (0%)     |           2/2 (100%)               0/1 (0%)        | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           733 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.500N     |                                    P=0.362N        | 
|POLY 3             |                                           P=0.500N     |                                    P=1.000N        | 
|POLY 1.5           |                                           P=0.500N     |                                    P=1.000N        | 
|POLY 6             |                                           P=0.500N     |                                    P=1.000N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.333N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)    |           0/49 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/46.45                  2/48.41      |           0/46.41                  1/46.19         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.1%         |           0.0%                     2.2%            | 
|TERMINAL (d)       |                  1/44 (2%)                2/47 (4%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           ---                      698             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.523      |                                    P=0.500         | 
|POLY 3             |                                           P=0.510      |                                    P=0.500         | 
|POLY 1.5           |                                           P=0.506      |                                    P=0.500         | 
|POLY 6             |                                           P=0.513      |                                    P=0.500         | 
|LOGISTIC REGRESSION|                                           P=0.523      |                                    P=0.510         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.505         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Peyer's Patch                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  0/48.41      |           0/47.03                  0/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/44 (5%)                0/47 (0%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.224N     |                                    (e)             | 
|POLY 3             |                                           P=0.224N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.229N     |                                    (e)             | 
|POLY 6             |                                           P=0.220N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                4/50 (8%)    |           1/50 (2%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  4/47.05                  4/48.41      |           1/47.03                  3/46.06         | 
|POLY-3 PERCENT (g) |                  8.5%                     8.3%         |           2.1%                     6.5%            | 
|TERMINAL (d)       |                  3/44 (7%)                4/47 (9%)    |           1/43 (2%)                3/41 (7%)       | 
|FIRST INCIDENCE    |                  538                      728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.607N     |                                    P=0.288         | 
|POLY 3             |                                           P=0.625N     |                                    P=0.300         | 
|POLY 1.5           |                                           P=0.631N     |                                    P=0.302         | 
|POLY 6             |                                           P=0.621N     |                                    P=0.299         | 
|LOGISTIC REGRESSION|                                           P=0.643      |                                    P=0.288         | 
|COCH-ARM / FISHERS |                                           P=0.643N     |                                    P=0.309         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)    |           0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  3/48.41      |           0/47.03                  0/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     6.2%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/44 (5%)                3/47 (6%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.530      |                                    (e)             | 
|POLY 3             |                                           P=0.515      |                                    (e)             | 
|POLY 1.5           |                                           P=0.510      |                                    (e)             | 
|POLY 6             |                                           P=0.520      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.530      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                5/50 (10%)   |           1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  5/48.41      |           1/47.03                  1/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     10.3%        |           2.1%                     2.2%            | 
|TERMINAL (d)       |                  2/44 (5%)                5/47 (11%)   |           1/43 (2%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.244      |                                    P=0.751         | 
|POLY 3             |                                           P=0.231      |                                    P=0.758         | 
|POLY 1.5           |                                           P=0.226      |                                    P=0.759         | 
|POLY 6             |                                           P=0.236      |                                    P=0.758         | 
|LOGISTIC REGRESSION|                                           P=0.244      |                                    P=0.751         | 
|COCH-ARM / FISHERS |                                           P=0.218      |                                    P=0.753N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  32/50 (64%)              39/50 (78%)  |           6/50 (12%)               0/50 (0%)       | 
|POLY-3 RATE (b)    |                  32/46.61                 39/49.92     |           6/47.13                  0/48.41         | 
|POLY-3 PERCENT (g) |                  68.7%                    78.1%        |           12.7%                    0.0%            | 
|TERMINAL (d)       |                  31/44 (71%)              37/47 (79%)  |           5/44 (11%)               0/47 (0%)       | 
|FIRST INCIDENCE    |                  687                      100          |           498                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.206      |                                    P=0.016N*       | 
|POLY 3             |                                           P=0.202      |                                    P=0.014N*       | 
|POLY 1.5           |                                           P=0.164      |                                    P=0.014N*       | 
|POLY 6             |                                           P=0.235      |                                    P=0.013N*       | 
|LOGISTIC REGRESSION|                                           P=0.111      |                                    P=0.018N*       | 
|COCH-ARM / FISHERS |                                           P=0.093      |                                    P=0.013N*       | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  0/48.41      |           1/47.67                  1/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%         |           2.1%                     2.2%            | 
|TERMINAL (d)       |                  2/44 (5%)                0/47 (0%)    |           0/43 (0%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           520                      733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.224N     |                                    P=0.750         | 
|POLY 3             |                                           P=0.224N     |                                    P=0.757         | 
|POLY 1.5           |                                           P=0.229N     |                                    P=0.758         | 
|POLY 6             |                                           P=0.220N     |                                    P=0.756         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.730N        | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.753N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  0/48.41      |           0/47.03                  1/46.48         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%         |           0.0%                     2.2%            | 
|TERMINAL (d)       |                  2/44 (5%)                0/47 (0%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           ---                      609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.224N     |                                    P=0.492         | 
|POLY 3             |                                           P=0.224N     |                                    P=0.500         | 
|POLY 1.5           |                                           P=0.229N     |                                    P=0.500         | 
|POLY 6             |                                           P=0.220N     |                                    P=0.500         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.541         | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  42/50 (84%)              44/50 (88%)  |           4/50 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  42/47.52                 44/49.00     |           4/47.03                  4/47.00         | 
|POLY-3 PERCENT (g) |                  88.4%                    89.8%        |           8.5%                     8.5%            | 
|TERMINAL (d)       |                  39/44 (89%)              42/47 (89%)  |           4/43 (9%)                2/41 (5%)       | 
|FIRST INCIDENCE    |                  498                      572          |           733 (T)                  570             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.520N     |                                    P=0.616         | 
|POLY 3             |                                           P=0.540      |                                    P=0.643         | 
|POLY 1.5           |                                           P=0.480      |                                    P=0.642         | 
|POLY 6             |                                           P=0.580      |                                    P=0.639N        | 
|LOGISTIC REGRESSION|                                           P=0.543      |                                    P=0.631N        | 
|COCH-ARM / FISHERS |                                           P=0.387      |                                    P=0.643N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  46/50 (92%)              47/50 (94%)  |           7/50 (14%)               11/50 (22%)     | 
|POLY-3 RATE (b)    |                  46/48.42                 47/49.92     |           7/47.33                  11/47.69        | 
|POLY-3 PERCENT (g) |                  95.0%                    94.2%        |           14.8%                    23.1%           | 
|TERMINAL (d)       |                  42/44 (96%)              45/47 (96%)  |           6/43 (14%)               8/41 (20%)      | 
|FIRST INCIDENCE    |                  340                      100          |           652                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.379N     |                                    P=0.199         | 
|POLY 3             |                                           P=0.602N     |                                    P=0.222         | 
|POLY 1.5           |                                           P=0.648N     |                                    P=0.220         | 
|POLY 6             |                                           P=0.571N     |                                    P=0.223         | 
|LOGISTIC REGRESSION|                                           P=0.539      |                                    P=0.234         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.218         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  6/50 (12%)               7/50 (14%)   |           24/50 (48%)              25/50 (50%)     | 
|POLY-3 RATE (b)    |                  6/46.45                  7/48.41      |           24/49.14                 25/47.88        | 
|POLY-3 PERCENT (g) |                  12.9%                    14.5%        |           48.8%                    52.2%           | 
|TERMINAL (d)       |                  6/44 (14%)               7/47 (15%)   |           20/43 (47%)              20/41 (49%)     | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           429                      456             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.551      |                                    P=0.426         | 
|POLY 3             |                                           P=0.529      |                                    P=0.450         | 
|POLY 1.5           |                                           P=0.519      |                                    P=0.468         | 
|POLY 6             |                                           P=0.538      |                                    P=0.436         | 
|LOGISTIC REGRESSION|                                           P=0.551      |                                    P=0.517         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.500         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)    |           1/50 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/47.05                  1/48.41      |           1/47.03                  0/45.21         | 
|POLY-3 PERCENT (g) |                  4.3%                     2.1%         |           2.1%                     0.0%            | 
|TERMINAL (d)       |                  1/44 (2%)                1/47 (2%)    |           1/43 (2%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  538                      728 (T)      |           733 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.480N     |                                    P=0.510N        | 
|POLY 3             |                                           P=0.487N     |                                    P=0.516N        | 
|POLY 1.5           |                                           P=0.491N     |                                    P=0.513N        | 
|POLY 6             |                                           P=0.484N     |                                    P=0.516N        | 
|LOGISTIC REGRESSION|                                           P=0.512N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.505N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                3/50 (6%)    |           1/50 (2%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  3/48.41      |           1/47.03                  4/45.21         | 
|POLY-3 PERCENT (g) |                  4.3%                     6.2%         |           2.1%                     8.9%            | 
|TERMINAL (d)       |                  2/44 (5%)                3/47 (6%)    |           1/43 (2%)                4/41 (10%)      | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.530      |                                    P=0.166         | 
|POLY 3             |                                           P=0.515      |                                    P=0.169         | 
|POLY 1.5           |                                           P=0.510      |                                    P=0.171         | 
|POLY 6             |                                           P=0.520      |                                    P=0.169         | 
|LOGISTIC REGRESSION|                                           P=0.530      |                                    P=0.166         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.175         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)    |           3/50 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  3/46.45                  1/48.41      |           3/47.03                  1/45.21         | 
|POLY-3 PERCENT (g) |                  6.5%                     2.1%         |           6.4%                     2.2%            | 
|TERMINAL (d)       |                  3/44 (7%)                1/47 (2%)    |           3/43 (7%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.282N     |                                    P=0.322N        | 
|POLY 3             |                                           P=0.287N     |                                    P=0.323N        | 
|POLY 1.5           |                                           P=0.294N     |                                    P=0.321N        | 
|POLY 6             |                                           P=0.282N     |                                    P=0.324N        | 
|LOGISTIC REGRESSION|                                           P=0.282N     |                                    P=0.322N        | 
|COCH-ARM / FISHERS |                                           P=0.309N     |                                    P=0.316N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                3/50 (6%)    |           5/50 (10%)               4/49 (8%)       | 
|POLY-3 RATE (b)    |                  3/46.45                  3/48.41      |           5/47.03                  4/46.11         | 
|POLY-3 PERCENT (g) |                  6.5%                     6.2%         |           10.6%                    8.7%            | 
|TERMINAL (d)       |                  3/44 (7%)                3/47 (6%)    |           5/43 (12%)               2/41 (5%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  456             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.632N     |                                    P=0.521N        | 
|POLY 3             |                                           P=0.640N     |                                    P=0.514N        | 
|POLY 1.5           |                                           P=0.648N     |                                    P=0.515N        | 
|POLY 6             |                                           P=0.633N     |                                    P=0.510N        | 
|LOGISTIC REGRESSION|                                           P=0.632N     |                                    P=0.498N        | 
|COCH-ARM / FISHERS |                                           P=0.661N     |                                    P=0.513N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)    |           4/50 (8%)                6/49 (12%)      | 
|POLY-3 RATE (b)    |                  1/46.45                  0/48.41      |           4/47.55                  6/46.10         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%         |           8.4%                     13.0%           | 
|TERMINAL (d)       |                  1/44 (2%)                0/47 (0%)    |           2/43 (5%)                4/41 (10%)      | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           652                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.487N     |                                    P=0.352         | 
|POLY 3             |                                           P=0.484N     |                                    P=0.352         | 
|POLY 1.5           |                                           P=0.490N     |                                    P=0.355         | 
|POLY 6             |                                           P=0.479N     |                                    P=0.351         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.382         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.357         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  26/50 (52%)              33/50 (66%)  |           39/50 (78%)              42/49 (86%)     | 
|POLY-3 RATE (b)    |                  26/46.61                 33/48.92     |           39/48.00                 42/47.80        | 
|POLY-3 PERCENT (g) |                  55.8%                    67.5%        |           81.3%                    87.9%           | 
|TERMINAL (d)       |                  25/44 (57%)              32/47 (68%)  |           36/43 (84%)              37/41 (90%)     | 
|FIRST INCIDENCE    |                  687                      572          |           627                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.201      |                                    P=0.179         | 
|POLY 3             |                                           P=0.166      |                                    P=0.264         | 
|POLY 1.5           |                                           P=0.142      |                                    P=0.249         | 
|POLY 6             |                                           P=0.188      |                                    P=0.285         | 
|LOGISTIC REGRESSION|                                           P=0.162      |                                    P=0.172         | 
|COCH-ARM / FISHERS |                                           P=0.111      |                                    P=0.232         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                5/50 (10%)   |           2/50 (4%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  3/46.45                  5/48.41      |           2/47.03                  1/45.21         | 
|POLY-3 PERCENT (g) |                  6.5%                     10.3%        |           4.3%                     2.2%            | 
|TERMINAL (d)       |                  3/44 (7%)                5/47 (11%)   |           2/43 (5%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.393      |                                    P=0.517N        | 
|POLY 3             |                                           P=0.377      |                                    P=0.518N        | 
|POLY 1.5           |                                           P=0.370      |                                    P=0.516N        | 
|POLY 6             |                                           P=0.383      |                                    P=0.519N        | 
|LOGISTIC REGRESSION|                                           P=0.393      |                                    P=0.517N        | 
|COCH-ARM / FISHERS |                                           P=0.357      |                                    P=0.508N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/50 (6%)                6/50 (12%)   |           6/50 (12%)               2/49 (4%)       | 
|POLY-3 RATE (b)    |                  3/46.45                  6/48.92      |           6/47.03                  2/45.21         | 
|POLY-3 PERCENT (g) |                  6.5%                     12.3%        |           12.8%                    4.4%            | 
|TERMINAL (d)       |                  3/44 (7%)                5/47 (11%)   |           6/43 (14%)               2/41 (5%)       | 
|FIRST INCIDENCE    |                  728 (T)                  572          |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.278      |                                    P=0.150N        | 
|POLY 3             |                                           P=0.266      |                                    P=0.148N        | 
|POLY 1.5           |                                           P=0.257      |                                    P=0.146N        | 
|POLY 6             |                                           P=0.274      |                                    P=0.148N        | 
|LOGISTIC REGRESSION|                                           P=0.246      |                                    P=0.150N        | 
|COCH-ARM / FISHERS |                                           P=0.243      |                                    P=0.141N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)    |           2/50 (4%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  1/46.45                  0/48.41      |           2/47.25                  3/45.64         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%         |           4.2%                     6.6%            | 
|TERMINAL (d)       |                  1/44 (2%)                0/47 (0%)    |           1/43 (2%)                2/41 (5%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           675                      609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.487N     |                                    P=0.481         | 
|POLY 3             |                                           P=0.484N     |                                    P=0.487         | 
|POLY 1.5           |                                           P=0.490N     |                                    P=0.489         | 
|POLY 6             |                                           P=0.479N     |                                    P=0.488         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.503         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.490         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Infiltration Cellular Lymphocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/50 (2%)                3/50 (6%)    |           26/50 (52%)              32/49 (65%)     | 
|POLY-3 RATE (b)    |                  1/46.45                  3/48.41      |           26/47.41                 32/45.96        | 
|POLY-3 PERCENT (g) |                  2.2%                     6.2%         |           54.9%                    69.6%           | 
|TERMINAL (d)       |                  1/44 (2%)                3/47 (6%)    |           25/43 (58%)              31/41 (76%)     | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           627                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.329      |                                    P=0.081         | 
|POLY 3             |                                           P=0.317      |                                    P=0.099         | 
|POLY 1.5           |                                           P=0.313      |                                    P=0.109         | 
|POLY 6             |                                           P=0.320      |                                    P=0.092         | 
|LOGISTIC REGRESSION|                                           P=0.329      |                                    P=0.090         | 
|COCH-ARM / FISHERS |                                           P=0.309      |                                    P=0.127         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  4/50 (8%)                2/50 (4%)    |           1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  4/46.45                  2/48.41      |           1/47.03                  1/46.06         | 
|POLY-3 PERCENT (g) |                  8.6%                     4.1%         |           2.1%                     2.2%            | 
|TERMINAL (d)       |                  4/44 (9%)                2/47 (4%)    |           1/43 (2%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.307N     |                                    P=0.751         | 
|POLY 3             |                                           P=0.316N     |                                    P=0.758         | 
|POLY 1.5           |                                           P=0.324N     |                                    P=0.759         | 
|POLY 6             |                                           P=0.309N     |                                    P=0.758         | 
|LOGISTIC REGRESSION|                                           P=0.307N     |                                    P=0.751         | 
|COCH-ARM / FISHERS |                                           P=0.339N     |                                    P=0.753N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/49 (0%)                0/49 (0%)    |           2/46 (4%)                0/47 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.45                  0/47.41      |           2/45.19                  0/44.98         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           4.4%                     0.0%            | 
|TERMINAL (d)       |                  0/43 (0%)                0/46 (0%)    |           1/42 (2%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           520                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.247N        | 
|POLY 3             |                                           (e)          |                                    P=0.239N        | 
|POLY 1.5           |                                           (e)          |                                    P=0.236N        | 
|POLY 6             |                                           (e)          |                                    P=0.242N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.147N        | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.242N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/48 (6%)                1/49 (2%)    |           0/49 (0%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  3/45.36                  1/47.92      |           0/46.33                  1/45.59         | 
|POLY-3 PERCENT (g) |                  6.6%                     2.1%         |           0.0%                     2.2%            | 
|TERMINAL (d)       |                  3/44 (7%)                1/47 (2%)    |           0/43 (0%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           ---                      733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.282N     |                                    P=0.490         | 
|POLY 3             |                                           P=0.282N     |                                    P=0.500         | 
|POLY 1.5           |                                           P=0.287N     |                                    P=0.500         | 
|POLY 6             |                                           P=0.278N     |                                    P=0.500         | 
|LOGISTIC REGRESSION|                                           P=0.282N     |                                    P=0.490         | 
|COCH-ARM / FISHERS |                                           P=0.301N     |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/48 (0%)                2/49 (4%)    |           0/49 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.36                  2/47.92      |           0/46.33                  0/45.59         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.2%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/44 (0%)                2/47 (4%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  ---                      728 (T)      |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.253      |                                    (e)             | 
|POLY 3             |                                           P=0.244      |                                    (e)             | 
|POLY 1.5           |                                           P=0.242      |                                    (e)             | 
|POLY 6             |                                           P=0.245      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.253      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.253      |                                    (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/48 (4%)                0/49 (0%)    |           0/49 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.36                  0/47.92      |           0/46.33                  0/45.59         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/44 (5%)                0/47 (0%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.224N     |                                    (e)             | 
|POLY 3             |                                           P=0.220N     |                                    (e)             | 
|POLY 1.5           |                                           P=0.223N     |                                    (e)             | 
|POLY 6             |                                           P=0.217N     |                                    (e)             | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.242N     |                                    (e)             | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  1/2 (50%)                0/0 (0%)     |           0/3 (0%)                 3/4 (75%)       | 
|POLY-3 RATE (b)    |                  1/2.00                   0/0.00       |           0/2.70                   3/3.59          | 
|POLY-3 PERCENT (g) |                  50.0%                    0.0%         |           0.0%                     83.6%           | 
|TERMINAL (d)       |                  1/2 (50%)                0/0 (0%)     |           0/2 (0%)                 3/3 (100%)      | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           ---                      733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=1.000      |                                    P=0.122         | 
|POLY 3             |                                           (e)          |                                    P=0.019 *       | 
|POLY 1.5           |                                           (e)          |                                    P=0.029 *       | 
|POLY 6             |                                           (e)          |                                    P=0.009 **      | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.122         | 
|COCH-ARM / FISHERS |                                           P=1.000      |                                    P=0.114         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  3/48 (6%)                2/48 (4%)    |           2/49 (4%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  3/45.59                  2/46.92      |           2/46.70                  5/46.06         | 
|POLY-3 PERCENT (g) |                  6.6%                     4.3%         |           4.3%                     10.9%           | 
|TERMINAL (d)       |                  3/44 (7%)                2/46 (4%)    |           1/43 (2%)                5/41 (12%)      | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           652                      733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.480N     |                                    P=0.200         | 
|POLY 3             |                                           P=0.484N     |                                    P=0.212         | 
|POLY 1.5           |                                           P=0.493N     |                                    P=0.216         | 
|POLY 6             |                                           P=0.477N     |                                    P=0.207         | 
|LOGISTIC REGRESSION|                                           P=0.480N     |                                    P=0.215         | 
|COCH-ARM / FISHERS |                                           P=0.500N     |                                    P=0.226         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/48 (0%)                2/48 (4%)    |           2/49 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.59                  2/46.92      |           2/46.70                  1/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.3%         |           4.3%                     2.2%            | 
|TERMINAL (d)       |                  0/44 (0%)                2/46 (4%)    |           1/43 (2%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  ---                      728 (T)      |           652                      733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.248      |                                    P=0.516N        | 
|POLY 3             |                                           P=0.241      |                                    P=0.507N        | 
|POLY 1.5           |                                           P=0.239      |                                    P=0.500N        | 
|POLY 6             |                                           P=0.242      |                                    P=0.513N        | 
|LOGISTIC REGRESSION|                                           P=0.248      |                                    P=0.489N        | 
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.492N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/48 (0%)                2/48 (4%)    |           17/49 (35%)              23/50 (46%)     | 
|POLY-3 RATE (b)    |                  0/45.59                  2/46.92      |           17/46.41                 23/47.64        | 
|POLY-3 PERCENT (g) |                  0.0%                     4.3%         |           36.6%                    48.3%           | 
|TERMINAL (d)       |                  0/44 (0%)                2/46 (4%)    |           17/43 (40%)              20/41 (49%)     | 
|FIRST INCIDENCE    |                  ---                      728 (T)      |           733 (T)                  463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.248      |                                    P=0.113         | 
|POLY 3             |                                           P=0.241      |                                    P=0.174         | 
|POLY 1.5           |                                           P=0.239      |                                    P=0.172         | 
|POLY 6             |                                           P=0.242      |                                    P=0.179         | 
|LOGISTIC REGRESSION|                                           P=0.248      |                                    P=0.151         | 
|COCH-ARM / FISHERS |                                           P=0.247      |                                    P=0.173         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           13/50 (26%)              10/50 (20%)     | 
|POLY-3 RATE (b)    |                                                        |           13/47.33                 10/46.19        | 
|POLY-3 PERCENT (g) |                                                        |           27.5%                    21.7%           | 
|TERMINAL (d)       |                                                        |           12/43 (28%)              9/41 (22%)      | 
|FIRST INCIDENCE    |                                                        |           652                      698             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.364N        | 
|POLY 3             |                                                        |                                    P=0.341N        | 
|POLY 1.5           |                                                        |                                    P=0.333N        | 
|POLY 6             |                                                        |                                    P=0.347N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.339N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.318N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           1/50 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                                                        |           1/47.03                  2/46.06         | 
|POLY-3 PERCENT (g) |                                                        |           2.1%                     4.3%            | 
|TERMINAL (d)       |                                                        |           1/43 (2%)                2/41 (5%)       | 
|FIRST INCIDENCE    |                                                        |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.483         | 
|POLY 3             |                                                        |                                    P=0.495         | 
|POLY 1.5           |                                                        |                                    P=0.497         | 
|POLY 6             |                                                        |                                    P=0.494         | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.483         | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)    |           1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/46.45                  0/48.41      |           1/47.03                  0/46.06         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%         |           2.1%                     0.0%            | 
|TERMINAL (d)       |                  2/44 (5%)                0/47 (0%)    |           1/43 (2%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  ---          |           733 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.224N     |                                    P=0.510N        | 
|POLY 3             |                                           P=0.224N     |                                    P=0.508N        | 
|POLY 1.5           |                                           P=0.229N     |                                    P=0.506N        | 
|POLY 6             |                                           P=0.220N     |                                    P=0.510N        | 
|LOGISTIC REGRESSION|                                           (e)          |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.247N     |                                    P=0.500N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  8/50 (16%)               10/50 (20%)  |           21/50 (42%)              25/50 (50%)     | 
|POLY-3 RATE (b)    |                  8/46.45                  10/48.41     |           21/47.03                 25/46.80        | 
|POLY-3 PERCENT (g) |                  17.2%                    20.7%        |           44.7%                    53.4%           | 
|TERMINAL (d)       |                  8/44 (18%)               10/47 (21%)  |           21/43 (49%)              24/41 (59%)     | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.458      |                                    P=0.193         | 
|POLY 3             |                                           P=0.433      |                                    P=0.259         | 
|POLY 1.5           |                                           P=0.420      |                                    P=0.264         | 
|POLY 6             |                                           P=0.444      |                                    P=0.257         | 
|LOGISTIC REGRESSION|                                           P=0.458      |                                    P=0.229         | 
|COCH-ARM / FISHERS |                                           P=0.398      |                                    P=0.274         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/48 (4%)                1/50 (2%)    |           1/48 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.05                  1/48.41      |           1/45.41                  0/45.09         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.1%         |           2.2%                     0.0%            | 
|TERMINAL (d)       |                  2/43 (5%)                1/47 (2%)    |           1/42 (2%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.469N     |                                    P=0.505N        | 
|POLY 3             |                                           P=0.467N     |                                    P=0.503N        | 
|POLY 1.5           |                                           P=0.472N     |                                    P=0.499N        | 
|POLY 6             |                                           P=0.463N     |                                    P=0.506N        | 
|LOGISTIC REGRESSION|                                           P=0.469N     |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.485N     |                                    P=0.495N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  5/48 (10%)               5/50 (10%)   |           5/48 (10%)               5/49 (10%)      | 
|POLY-3 RATE (b)    |                  5/45.05                  5/48.41      |           5/45.41                  5/45.09         | 
|POLY-3 PERCENT (g) |                  11.1%                    10.3%        |           11.0%                    11.1%           | 
|TERMINAL (d)       |                  5/43 (12%)               5/47 (11%)   |           5/42 (12%)               5/41 (12%)      | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.574N     |                                    P=0.616         | 
|POLY 3             |                                           P=0.580N     |                                    P=0.626         | 
|POLY 1.5           |                                           P=0.587N     |                                    P=0.628N        | 
|POLY 6             |                                           P=0.574N     |                                    P=0.622         | 
|LOGISTIC REGRESSION|                                           P=0.574N     |                                    P=0.616         | 
|COCH-ARM / FISHERS |                                           P=0.603N     |                                    P=0.617N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  26/50 (52%)              29/50 (58%)  |                                                    | 
|POLY-3 RATE (b)    |                  26/47.35                 29/48.41     |                                                    | 
|POLY-3 PERCENT (g) |                  54.9%                    59.9%        |                                                    | 
|TERMINAL (d)       |                  25/44 (57%)              29/47 (62%)  |                                                    | 
|FIRST INCIDENCE    |                  340                      728 (T)      |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.482      |                                                    | 
|POLY 3             |                                           P=0.386      |                                                    | 
|POLY 1.5           |                                           P=0.366      |                                                    | 
|POLY 6             |                                           P=0.407      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.404      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.344      |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland: Duct                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  15/50 (30%)              20/50 (40%)  |                                                    | 
|POLY-3 RATE (b)    |                  15/46.45                 20/48.49     |                                                    | 
|POLY-3 PERCENT (g) |                  32.3%                    41.3%        |                                                    | 
|TERMINAL (d)       |                  15/44 (34%)              19/47 (40%)  |                                                    | 
|FIRST INCIDENCE    |                  728 (T)                  708          |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.275      |                                                    | 
|POLY 3             |                                           P=0.244      |                                                    | 
|POLY 1.5           |                                           P=0.227      |                                                    | 
|POLY 6             |                                           P=0.260      |                                                    | 
|LOGISTIC REGRESSION|                                           P=0.270      |                                                    | 
|COCH-ARM / FISHERS |                                           P=0.201      |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)    |           0/48 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/46.45                  3/48.49      |           0/46.21                  0/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.2%         |           0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/44 (0%)                2/47 (4%)    |           0/43 (0%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  ---                      708          |           ---                      ---             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.136      |                                    (e)             | 
|POLY 3             |                                           P=0.124      |                                    (e)             | 
|POLY 1.5           |                                           P=0.122      |                                    (e)             | 
|POLY 6             |                                           P=0.126      |                                    (e)             | 
|LOGISTIC REGRESSION|                                           P=0.126      |                                    (e)             | 
|COCH-ARM / FISHERS |                                           P=0.121      |                                    (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  30/50 (60%)              31/50 (62%)  |           25/48 (52%)              32/50 (64%)     | 
|POLY-3 RATE (b)    |                  30/47.05                 31/48.41     |           25/46.50                 32/47.52        | 
|POLY-3 PERCENT (g) |                  63.8%                    64.0%        |           53.8%                    67.3%           | 
|TERMINAL (d)       |                  29/44 (66%)              31/47 (66%)  |           24/43 (56%)              28/41 (68%)     | 
|FIRST INCIDENCE    |                  538                      728 (T)      |           652                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.500N     |                                    P=0.073         | 
|POLY 3             |                                           P=0.572      |                                    P=0.124         | 
|POLY 1.5           |                                           P=0.547      |                                    P=0.135         | 
|POLY 6             |                                           P=0.577N     |                                    P=0.117         | 
|LOGISTIC REGRESSION|                                           P=0.551N     |                                    P=0.105         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.161         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  7/50 (14%)               8/50 (16%)   |           11/48 (23%)              16/49 (33%)     | 
|POLY-3 RATE (b)    |                  7/48.03                  8/48.92      |           11/48.00                 16/47.49        | 
|POLY-3 PERCENT (g) |                  14.6%                    16.4%        |           22.9%                    33.7%           | 
|TERMINAL (d)       |                  5/44 (11%)               7/47 (15%)   |           6/43 (14%)               10/41 (24%)     | 
|FIRST INCIDENCE    |                  340                      572          |           429                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.547      |                                    P=0.180         | 
|POLY 3             |                                           P=0.514      |                                    P=0.174         | 
|POLY 1.5           |                                           P=0.507      |                                    P=0.182         | 
|POLY 6             |                                           P=0.522      |                                    P=0.168         | 
|LOGISTIC REGRESSION|                                           P=0.472      |                                    P=0.281         | 
|COCH-ARM / FISHERS |                                           P=0.500      |                                    P=0.200         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           2/48 (4%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  0/46.45                  0/48.41      |           2/45.75                  4/45.09         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           4.4%                     8.9%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           2/43 (5%)                4/41 (10%)      | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.315         | 
|POLY 3             |                                           (e)          |                                    P=0.332         | 
|POLY 1.5           |                                           (e)          |                                    P=0.337         | 
|POLY 6             |                                           (e)          |                                    P=0.327         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.315         | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.349         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  2/48 (4%)                0/50 (0%)    |           3/50 (6%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.71                  0/48.41      |           3/48.21                  1/46.82         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%         |           6.2%                     2.1%            | 
|TERMINAL (d)       |                  0/43 (0%)                0/47 (0%)    |           1/43 (2%)                0/41 (0%)       | 
|FIRST INCIDENCE    |                  498                      ---          |           429                      456             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.233N     |                                    P=0.319N        | 
|POLY 3             |                                           P=0.226N     |                                    P=0.319N        | 
|POLY 1.5           |                                           P=0.226N     |                                    P=0.314N        | 
|POLY 6             |                                           P=0.225N     |                                    P=0.323N        | 
|LOGISTIC REGRESSION|                                           P=0.151N     |                                    P=0.158N        | 
|COCH-ARM / FISHERS |                                           P=0.237N     |                                    P=0.309N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)    |           1/50 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/46.45                  0/48.41      |           1/47.03                  2/46.06         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           2.1%                     4.3%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           1/43 (2%)                2/41 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.483         | 
|POLY 3             |                                           (e)          |                                    P=0.495         | 
|POLY 1.5           |                                           (e)          |                                    P=0.497         | 
|POLY 6             |                                           (e)          |                                    P=0.494         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.483         | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.500         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/44 (0%)                2/43 (5%)    |           5/46 (11%)               2/47 (4%)       | 
|POLY-3 RATE (b)    |                  0/40.61                  2/41.92      |           5/44.56                  2/44.05         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.8%         |           11.2%                    4.5%            | 
|TERMINAL (d)       |                  0/39 (0%)                2/41 (5%)    |           2/40 (5%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      728 (T)      |           520                      609             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.249      |                                    P=0.233N        | 
|POLY 3             |                                           P=0.241      |                                    P=0.221N        | 
|POLY 1.5           |                                           P=0.238      |                                    P=0.216N        | 
|POLY 6             |                                           P=0.243      |                                    P=0.225N        | 
|LOGISTIC REGRESSION|                                           P=0.249      |                                    P=0.162N        | 
|COCH-ARM / FISHERS |                                           P=0.241      |                                    P=0.209N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  0/50 (0%)                0/49 (0%)    |           0/48 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/46.45                  0/47.49      |           0/46.21                  2/46.19         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%         |           0.0%                     4.3%            | 
|TERMINAL (d)       |                  0/44 (0%)                0/47 (0%)    |           0/43 (0%)                1/41 (2%)       | 
|FIRST INCIDENCE    |                  ---                      ---          |           ---                      698             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           (e)          |                                    P=0.235         | 
|POLY 3             |                                           (e)          |                                    P=0.237         | 
|POLY 1.5           |                                           (e)          |                                    P=0.239         | 
|POLY 6             |                                           (e)          |                                    P=0.236         | 
|LOGISTIC REGRESSION|                                           (e)          |                                    P=0.244         | 
|COCH-ARM / FISHERS |                                           (e)          |                                    P=0.258         | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  6/50 (12%)               4/49 (8%)    |           7/48 (15%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/46.45                  4/47.49      |           7/46.21                  3/46.06         | 
|POLY-3 PERCENT (g) |                  12.9%                    8.4%         |           15.2%                    6.5%            | 
|TERMINAL (d)       |                  6/44 (14%)               4/47 (9%)    |           7/43 (16%)               3/41 (7%)       | 
|FIRST INCIDENCE    |                  728 (T)                  728 (T)      |           733 (T)                  733 (T)         | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.329N     |                                    P=0.177N        | 
|POLY 3             |                                           P=0.355N     |                                    P=0.159N        | 
|POLY 1.5           |                                           P=0.366N     |                                    P=0.152N        | 
|POLY 6             |                                           P=0.345N     |                                    P=0.164N        | 
|LOGISTIC REGRESSION|                                           P=0.329N     |                                    P=0.177N        | 
|COCH-ARM / FISHERS |                                           P=0.383N     |                                    P=0.142N        | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                  20/50 (40%)              16/50 (32%)  |           34/50 (68%)              33/50 (66%)     | 
|POLY-3 RATE (b)    |                  20/47.13                 16/48.41     |           34/48.50                 33/47.37        | 
|POLY-3 PERCENT (g) |                  42.4%                    33.1%        |           70.1%                    69.7%           | 
|TERMINAL (d)       |                  19/44 (43%)              16/47 (34%)  |           31/43 (72%)              30/41 (73%)     | 
|FIRST INCIDENCE    |                  498                      728 (T)      |           429                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                           P=0.191N     |                                    P=0.538         | 
|POLY 3             |                                           P=0.231N     |                                    P=0.572N        | 
|POLY 1.5           |                                           P=0.243N     |                                    P=0.548N        | 
|POLY 6             |                                           P=0.221N     |                                    P=0.587N        | 
|LOGISTIC REGRESSION|                                           P=0.224N     |                                    P=0.547N        | 
|COCH-ARM / FISHERS |                                           P=0.266N     |                                    P=0.500N        | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           1/50 (2%)                7/50 (14%)      | 
|POLY-3 RATE (b)    |                                                        |           1/47.03                  7/46.47         | 
|POLY-3 PERCENT (g) |                                                        |           2.1%                     15.1%           | 
|TERMINAL (d)       |                                                        |           1/43 (2%)                6/41 (15%)      | 
|FIRST INCIDENCE    |                                                        |           733 (T)                  614             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.029 *       | 
|POLY 3             |                                                        |                                    P=0.029 *       | 
|POLY 1.5           |                                                        |                                    P=0.029 *       | 
|POLY 6             |                                                        |                                    P=0.029 *       | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.031 *       | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.030 *       | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  06/14/01                           EXPERIMENT: 56111 TEST: 04                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   TRANS-CINNAMALDEHYDE 
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |                  UNTREATD                 VEHICLE      |           UNTREATD                 VEHICLE         | 
|                   |                  CONTROL                  CONTROL      |           CONTROL                  CONTROL         | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |           43/50 (86%)              42/50 (84%)     | 
|POLY-3 RATE (b)    |                                                        |           43/47.92                 42/48.12        | 
|POLY-3 PERCENT (g) |                                                        |           89.7%                    87.3%           | 
|TERMINAL (d)       |                                                        |           40/43 (93%)              38/41 (93%)     | 
|FIRST INCIDENCE    |                                                        |           627                      463             | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |                                    P=0.506         | 
|POLY 3             |                                                        |                                    P=0.476N        | 
|POLY 1.5           |                                                        |                                    P=0.483N        | 
|POLY 6             |                                                        |                                    P=0.475N        | 
|LOGISTIC REGRESSION|                                                        |                                    P=0.622N        | 
|COCH-ARM / FISHERS |                                                        |                                    P=0.500N        | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).