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TDMS Study 56348-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                       CITRAL                                                 DATE: 07/05/01  
EXPERIMENT: 56348 TEST: 04                                                                                        TIME: 14:02:03    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56348      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS LABORATORY                     CITRAL                                                      DATE: 07/05/01    
EXPERIMENT: 56348 TEST: 04                                                                                        TIME: 14:19:56    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56348      
CONT: N01-ES-55384                                                                                                CAS: 5392-40-5    
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                                   CHRONIC DOSED FEED STUDY OF CITRAL                                               
==================================================================================================================================  
      UNTREAT CONTROL             VEHICLE CONTROL                        500 PPM                            1000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.6    22.0       4.7     22.3    1.02        0      4.7     22.4    1.02      325      4.6     21.8    1.00      657       
  6     5.1    25.9       5.2     26.8    1.02        0      5.3     26.5    1.04      311      5.2     26.0    1.02      622       
 10     5.0    29.5       5.2     30.4    1.04        0      5.1     30.1    1.02      267      5.1     29.2    1.02      550       
 14     4.8    31.9       5.1     32.9    1.06        0      5.1     32.4    1.06      244      5.1     31.6    1.06      501       
 18     4.5    33.8       4.3     34.2    0.96        0      4.3     34.0    0.96      196      4.6     33.4    1.02      429       
 22     4.6    35.6       4.8     36.4    1.04        0      4.7     35.9    1.02      203      4.8     34.6    1.04      431       
 26     4.8    37.4       4.9     38.3    1.02        0      4.7     37.6    0.98      197      4.7     36.3    0.98      400       
 30     4.8    39.4       5.0     40.4    1.04        0      4.7     39.6    0.98      187      4.8     38.6    1.00      388       
 34     4.6    40.8       4.8     42.3    1.04        0      4.6     41.0    1.00      173      4.6     40.1    1.00      357       
 38     4.5    42.4       4.7     43.4    1.04        0      4.5     42.2    1.00      167      4.4     40.9    0.98      332       
 42     4.6    42.9       4.4     43.4    0.96        0      4.5     42.6    0.98      166      4.6     41.6    1.00      342       
 46     4.7    42.6       4.8     43.9    1.02        0      4.6     43.1    0.98      168      4.6     41.7    0.98      344       
 50     4.5    43.5       4.7     45.1    1.04        0      4.5     44.0    1.00      160      4.5     42.7    1.00      330       
 54     4.7    44.1       4.7     44.9    1.00        0      4.5     43.5    0.96      162      4.5     42.6    0.96      332       
 58     4.7    43.9       4.7     45.3    1.00        0      4.7     44.0    1.00      165      4.6     42.0    0.98      339       
 62     4.4    43.1       4.7     44.9    1.07        0      4.6     43.9    1.05      162      4.5     42.2    1.02      330       
 66     4.5    43.8       4.6     44.7    1.02        0      4.6     44.5    1.02      162      4.6     42.8    1.02      335       
 70     4.6    45.2       4.5     44.6    0.98        0      4.6     44.5    1.00      161      4.6     43.6    1.00      330       
 74     4.4    45.8       4.3     45.6    0.98        0      4.2     45.8    0.95      143      4.2     44.1    0.95      297       
 78     4.2    46.2       4.6     48.2    1.10        0      4.3     46.4    1.02      144      4.3     44.8    1.02      302       
 82     4.4    47.2       4.6     49.6    1.05        0      4.4     46.8    1.00      148      4.4     45.3    1.00      302       
 86     4.7    47.4       5.1     49.5    1.09        0      4.7     46.9    1.00      155      4.7     45.7    1.00      320       
 90     4.7    45.4       4.8     47.6    1.02        0      4.8     45.2    1.02      166      4.8     44.0    1.02      338       
 94     4.6    45.6       4.9     47.9    1.07        0      4.6     45.0    1.00      161      4.4     43.4    0.96      317       
 98     4.8    45.5       4.9     47.0    1.02        0      4.7     44.9    0.98      162      4.6     42.9    0.96      333       
102     5.1    44.0       5.3     45.9    1.04        0      5.2     42.8    1.02      189      5.1     41.6    1.00      382       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.9    25.8       5.0     26.5    1.03        0      5.0     26.3    1.03      301      5.0     25.7    1.01      610       
SD(D)   0.3               0.3             0.01        0      0.3             0.01       30      0.3             0.01       55       
CV(E)   5.6               5.6             1.1                6.7             1.0      10.1      6.6             1.1       9.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6    39.0       4.8     40.0    1.02        0      4.6     39.2    1.00      186      4.7     38.2    1.01      385       
SD(D)   0.1               0.2             0.04        0      0.2             0.03       25      0.2             0.03       56       
CV(E)   2.7               4.9             3.7                4.5             3.0      13.7      4.2             2.8      14.5       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.6    45.2       4.7     46.6    1.03        0      4.6     44.9    1.00      160      4.6     43.5    0.99      327       
SD(D)   0.2               0.3             0.04        0      0.2             0.03       12      0.2             0.03       22       
CV(E)   5.2               5.3             3.7                5.2             2.6       7.3      4.9             2.8       6.7       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
       CHRONIC DOSED FEED STUDY OF CITRAL                                                                                           
==========================================                                                                                          
                    2000 PPM                                                                                                        
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  2     4.5     21.5     0.98    1320                                                                                               
  6     5.3     25.4     1.04    1304                                                                                               
 10     5.2     28.1     1.04    1160                                                                                               
 14     5.1     30.5     1.06    1035                                                                                               
 18     4.5     32.3     1.00     870                                                                                               
 22     4.7     33.7     1.02     880                                                                                               
 26     4.7     35.7     0.98     818                                                                                               
 30     4.7     37.2     0.98     786                                                                                               
 34     4.5     38.2     0.98     731                                                                                               
 38     4.3     39.1     0.96     692                                                                                               
 42     4.5     40.0     0.98     697                                                                                               
 46     4.4     39.9     0.94     684                                                                                               
 50     4.4     40.6     0.98     671                                                                                               
 54     4.3     40.4     0.91     665                                                                                               
 58     4.5     40.6     0.96     690                                                                                               
 62     4.4     40.2     1.00     687                                                                                               
 66     4.3     40.4     0.96     667                                                                                               
 70     4.3     40.6     0.93     659                                                                                               
 74     4.1     41.2     0.93     620                                                                                               
 78     4.1     41.5     0.98     616                                                                                               
 82     4.4     42.0     1.00     658                                                                                               
 86     4.4     41.3     0.94     664                                                                                               
 90     4.6     39.8     0.98     718                                                                                               
 94     4.4     40.1     0.96     681                                                                                               
 98     4.4     39.7     0.92     691                                                                                               
102     4.8     38.6     0.94     783                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.0     25.0     1.02    1261                                                                                               
SD(D)   0.4              0.04      88                                                                                               
CV(E)   8.1              3.5      7.0                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6     36.7     0.99     786                                                                                               
SD(D)   0.2              0.03     117                                                                                               
CV(E)   5.0              3.5     14.8                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.4     40.5     0.95     677                                                                                               
SD(D)   0.2              0.03      42                                                                                               
CV(E)   4.4              3.0      6.3                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                                   CHRONIC DOSED FEED STUDY OF CITRAL                                               
==================================================================================================================================  
      UNTREAT CONTROL             VEHICLE CONTROL                        500 PPM                            1000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.8    17.9       3.7     17.6     0.97       0      3.7     17.7     0.97     323      3.6     17.8     0.95     639       
  2     3.9    18.3       4.6     18.2     1.18       0      4.0     18.1     1.03     340      4.0     18.3     1.03     685       
  6     4.9    22.7       5.5     22.5     1.12       0      4.8     22.5     0.98     332      4.7     22.4     0.96     648       
 10     5.0    25.7       5.0     26.1     1.00       0      4.9     25.3     0.98     301      4.7     25.4     0.94     581       
 14     4.4    28.1       4.7     28.3     1.07       0      4.5     27.8     1.02     251      4.2     26.6     0.95     496       
 18     3.9    29.2       4.2     31.2     1.08       0      4.2     29.8     1.08     221      3.8     29.2     0.97     411       
 22     4.6    28.8       4.1     31.0     0.89       0      4.3     29.8     0.93     227      4.2     29.1     0.91     451       
 26     4.7    31.5       4.7     33.4     1.00       0      4.6     31.6     0.98     227      4.6     31.6     0.98     457       
 30     4.6    33.5       4.3     35.4     0.93       0      4.2     33.4     0.91     196      4.3     33.4     0.93     398       
 34     4.5    35.6       4.4     37.8     0.98       0      4.3     35.1     0.96     190      4.0     35.3     0.89     356       
 38     3.8    35.9       4.1     38.6     1.08       0      3.9     35.5     1.03     171      3.8     35.7     1.00     333       
 42     3.8    36.1       3.7     39.2     0.97       0      3.9     36.5     1.03     165      3.8     35.8     1.00     329       
 46     4.2    37.1       3.3     37.9     0.79       0      2.8     34.5     0.67     125      3.1     34.6     0.74     283       
 50     4.4    38.0       4.2     40.0     0.95       0      4.1     37.0     0.93     174      3.9     36.1     0.89     337       
 54     4.3    39.4       4.4     40.6     1.02       0      4.3     37.5     1.00     178      4.1     36.4     0.95     354       
 58     4.5    39.8       4.5     41.4     1.00       0      4.0     38.5     0.89     161      3.9     37.2     0.87     331       
 62     4.0    39.9       4.0     41.3     1.00       0      4.2     39.0     1.05     166      4.1     37.0     1.03     344       
 66     4.3    39.9       4.2     41.1     0.98       0      4.0     39.0     0.93     160      3.6     37.1     0.84     305       
 70     4.1    42.2       3.9     41.8     0.95       0      3.7     39.2     0.90     147      3.6     38.7     0.88     294       
 74     4.3    41.7       4.0     42.1     0.93       0      4.2     40.0     0.98     163      4.1     38.3     0.95     338       
 78     4.1    43.9       3.8     44.3     0.93       0      3.6     41.5     0.88     134      3.4     39.6     0.83     265       
 82     4.0    45.9       4.1     46.7     1.03       0      3.7     42.8     0.93     134      3.7     41.3     0.93     276       
 86     4.2    47.4       4.3     47.2     1.02       0      3.5     43.4     0.83     127      3.7     41.5     0.88     279       
 90     5.5    47.2       4.8     46.5     0.87       0      4.6     43.6     0.84     163      4.5     41.4     0.82     343       
 94     4.6    47.2       4.9     47.3     1.07       0      4.1     43.8     0.89     148      4.2     42.8     0.91     303       
 98     4.8    47.5       4.8     48.0     1.00       0      4.6     43.5     0.96     164      4.4     42.5     0.92     319       
102     5.2    45.9       5.3     47.1     1.02       0      5.0     42.9     0.96     181      4.8     41.4     0.92     363       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4    21.2       4.7     21.1     1.07       0      4.3     20.9     0.99     324      4.3     21.0     0.97     638       
SD(D)   0.6               0.8              0.10       0      0.6              0.02      17      0.5              0.04      43       
CV(E)  14.6              16.6              9.2              14.0              2.4      5.1     12.2              4.0      6.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.3    33.4       4.2     35.3     0.97       0      4.1     33.1     0.95     195      4.0     32.7     0.93     385       
SD(D)   0.3               0.4              0.09       0      0.5              0.11      38      0.4              0.08      68       
CV(E)   8.0              10.2              9.4              12.6             11.9     19.3     10.0              8.5     17.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.5    43.7       4.4     44.3     0.99       0      4.1     41.1     0.93     156      4.0     39.6     0.90     316       
SD(D)   0.5               0.5              0.05       0      0.4              0.06      17      0.4              0.06      32       
CV(E)  10.4              10.5              5.3              10.5              6.8     10.7     10.2              6.4     10.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
       CHRONIC DOSED FEED STUDY OF CITRAL                                                                                           
==========================================                                                                                          
                    2000 PPM                                                                                                        
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       FEED/   WEIGHT  FEED (B)    DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1     3.5     17.6     0.92    1261                                                                                               
  2     3.8     17.9     0.97    1313                                                                                               
  6     4.9     21.7     1.00    1415                                                                                               
 10     5.2     24.6     1.04    1325                                                                                               
 14     4.4     25.7     1.00    1063                                                                                               
 18     4.4     27.9     1.13     977                                                                                               
 22     4.4     27.8     0.96     985                                                                                               
 26     4.4     29.5     0.94     937                                                                                               
 30     4.4     31.0     0.96     885                                                                                               
 34     4.1     31.9     0.91     802                                                                                               
 38     4.0     32.6     1.05     761                                                                                               
 42     3.9     34.0     1.03     723                                                                                               
 46     3.3     32.4     0.79     630                                                                                               
 50     3.8     34.2     0.86     701                                                                                               
 54     4.1     35.0     0.95     732                                                                                               
 58     3.8     35.3     0.84     669                                                                                               
 62     4.1     35.6     1.03     722                                                                                               
 66     3.6     35.1     0.84     632                                                                                               
 70     3.6     35.6     0.88     628                                                                                               
 74     3.9     35.4     0.91     697                                                                                               
 78     3.7     36.4     0.90     630                                                                                               
 82     3.6     36.9     0.90     609                                                                                               
 86     4.2     37.5     1.00     693                                                                                               
 90     4.4     37.0     0.80     734                                                                                               
 94     4.2     37.6     0.91     699                                                                                               
 98     4.7     37.6     0.98     784                                                                                               
102     5.1     36.6     0.98     864                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4     20.4     0.98    1328                                                                                               
SD(D)   0.8              0.05      64                                                                                               
CV(E)  18.9              5.1      4.8                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.1     30.7     0.96     846                                                                                               
SD(D)   0.4              0.10     144                                                                                               
CV(E)   9.0             10.1     17.0                                                                                               
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.1     36.3     0.92     699                                                                                               
SD(D)   0.5              0.07      71                                                                                               
CV(E)  11.3              7.4     10.2                                                                                               
==========================================                                                                                          
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                                  DIAGNOSTIC TRAILER REPORT                                                         
                                                  FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                 
                                                  CHRONIC DOSED FEED STUDY OF CITRAL                                                
==================================================================================================================================  
      UNTREAT CONTROL          VEHICLE CONTROL              500 PPM                  1000 PPM                 2000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               21.6  50                 21.7  50                 21.8  50                 21.7  50                 21.7  50      
  1               21.6  50                 21.7  50                 21.8  50                 21.7  50                 21.7  50      
  2   4.6  8155   22.0  50     4.7  8202   22.3  50     4.7  8251   22.4  50     4.6  8367   21.8  50     4.5  8401   21.5  50      
  6   5.1  8398   25.9  50     5.2  8357   26.8  50     5.3  8359   26.5  50     5.2  8376   26.0  50     5.3  8386   25.4  50      
 10   5.0  8374   29.5  50     5.2  8350   30.4  50     5.1  8359   30.1  50     5.1  8386   29.2  50     5.2  8400   28.1  50      
 14   4.8  8304   31.9  50     5.1  8350   32.9  50     5.1  8333   32.4  50     5.1  8340   31.6  50     5.1  8385   30.5  50      
 18   4.5  8544   33.8  50     4.3  8514   34.2  50     4.3  8484   34.0  50     4.6  8401   33.4  50     4.5  8375   32.3  50      
 22   4.6  8317   35.6  50     4.8  8177   36.4  49     4.7  8350   35.9  50     4.8  8369   34.6  50     4.7  8383   33.7  50      
 26   4.8  8490   37.4  50     4.9  8320   38.3  49     4.7  8524   37.6  50     4.7  8483   36.3  50     4.7  8376   35.7  50      
 30   4.8  8181   39.4  50     5.0  8036   40.4  49     4.7  8177   39.6  50     4.8  8186   38.6  50     4.7  8214   37.2  50      
 34   4.6  8392   40.8  50     4.8  8255   42.3  49     4.6  8404   41.0  50     4.6  8408   40.1  50     4.5  8414   38.2  50      
 38   4.5  8360   42.4  50     4.7  8184   43.4  49     4.5  8381   42.2  50     4.4  8500   40.9  50     4.3  8515   39.1  50      
 42   4.6  8589   42.9  50     4.4  8363   43.4  49     4.5  8480   42.6  50     4.6  8430   41.6  50     4.5  8366   40.0  50      
 46   4.7  8417   42.6  50     4.8  8026   43.9  48     4.6  8283   43.1  50     4.6  8230   41.7  50     4.4  8382   39.9  50      
 50   4.5  8418   43.5  50     4.7  8125   45.1  48     4.5  8434   44.0  50     4.5  8433   42.7  50     4.4  8450   40.6  50      
 54   4.7  8182   44.1  50     4.7  7977   44.9  48     4.5  8402   43.5  50     4.5  8411   42.6  50     4.3  8451   40.4  50      
 58   4.7  8200   43.9  49     4.7  8064   45.3  48     4.7  8405   44.0  50     4.6  8374   42.0  50     4.5  8397   40.6  50      
 62   4.4  8330   43.1  49     4.7  8167   44.9  48     4.6  8160   43.9  48     4.5  8336   42.2  49     4.4  8460   40.2  50      
 66   4.5  8299   43.8  49     4.6  8148   44.7  48     4.6  8155   44.5  48     4.6  8338   42.8  49     4.3  8194   40.4  48      
 70   4.6  8237   45.2  49     4.5  8112   44.6  48     4.6  8191   44.5  48     4.6  8272   43.6  49     4.3  8189   40.6  48      
 74   4.4  8196   45.8  49     4.3  8050   45.6  48     4.2  7856   45.8  46     4.2  8150   44.1  49     4.1  8047   41.2  47      
 78   4.2  8159   46.2  49     4.6  7676   48.2  46     4.3  7710   46.4  46     4.3  8232   44.8  49     4.1  7924   41.5  47      
 82   4.4  8188   47.2  49     4.6  7671   49.6  46     4.4  7697   46.8  46     4.4  8267   45.3  49     4.4  7943   42.0  47      
 86   4.7  8304   47.4  49     5.1  7808   49.5  46     4.7  7645   46.9  45     4.7  8330   45.7  49     4.4  8014   41.3  47      
 90   4.7  8358   45.4  49     4.8  7833   47.6  46     4.8  7485   45.2  44     4.8  8191   44.0  48     4.6  7867   39.8  46      
 93                                                     6.7    66                5.4    22                                          
 94   4.6  8043   45.6  48     4.9  7549   47.9  45     4.6  6991   45.0  42     4.4  7916   43.4  47     4.4  7270   40.1  43      
 98   4.8  7932   45.5  48     4.9  7451   47.0  45     4.7  6890   44.9  41     4.6  7937   42.9  47     4.4  7098   39.7  42      
102   5.1  8081   44.0  48     5.3  7267   45.9  43     5.2  6962   42.8  41     5.1  7480   41.6  44     4.8  6807   38.6  40      
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                                  DIAGNOSTIC TRAILER REPORT                                                         
                                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                               
                                                  CHRONIC DOSED FEED STUDY OF CITRAL                                                
==================================================================================================================================  
      UNTREAT CONTROL          VEHICLE CONTROL              500 PPM                  1000 PPM                 2000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               17.9  50                 17.6  50                 17.7  50                 17.8  50                 17.6  50      
  1   3.8  4583   17.9  50     3.7  4586   17.6  50     3.7  4590   17.7  50     3.6  4599   17.8  50     3.5  4655   17.6  50      
  2   3.9  3662   18.3  50     4.6  3702   18.2  50     4.0  3716   18.1  50     4.0  3724   18.3  50     3.8  3701   17.9  50      
  5   4.3  4694                4.3  4793                4.3  4795                4.1  4800                4.3  4800                 
  6   4.9  3532   22.7  49     5.5  3626   22.5  50     4.8  3668   22.5  50     4.7  3703   22.4  50     4.9  3726   21.7  50      
  9   4.4  4724                4.3  4817                4.7  4820                4.1  4819                4.6  4820                 
 10   5.0  3516   25.7  49     5.0  3604   26.1  50     4.9  3624   25.3  50     4.7  3669   25.4  50     5.2  3697   24.6  50      
 13   3.7  4821                4.1  4895                3.9  4870                4.0  4870                4.1  4860                 
 14   4.4  3320   28.1  49     4.7  3449   28.3  50     4.5  3529   27.8  50     4.2  3573   26.6  50     4.4  3628   25.7  50      
 17   3.4  4766                3.6  4827                3.6  4900                3.4  4900                3.5  4903                 
 18   3.9  3621   29.2  49     4.2  3512   31.2  49     4.2  3583   29.8  50     3.8  3610   29.2  50     4.4  3510   27.9  50      
 21   3.0  4822                3.5  4709                3.3  4916                3.4  4837                3.7  4860                 
 22   4.6  3534   28.8  49     4.1  3549   31.0  49     4.3  3689   29.8  50     4.2  3703   29.1  50     4.4  3717   27.8  50      
 25   3.9  4775                3.9  4770                3.9  4867                4.0  4817                3.9  4820                 
 26   4.7  3484   31.5  49     4.7  3494   33.4  49     4.6  3589   31.6  50     4.6  3588   31.6  50     4.4  3590   29.5  50      
 29   3.5  4764                3.8  4769                3.5  4866                3.6  4870                3.5  4872                 
 30   4.6  3531   33.5  49     4.3  3565   35.4  49     4.2  3680   33.4  50     4.3  3698   33.4  50     4.4  3718   31.0  50      
 33   3.8  4641                3.8  4561                3.7  4653                3.8  4660                3.7  4661                 
 34   4.5  3455   35.6  49     4.4  3479   37.8  49     4.3  3565   35.1  50     4.0  3589   35.3  50     4.1  3613   31.9  50      
 37   3.7  4529                3.8  4821                3.6  4915                3.4  4920                3.5  4915                 
 38   3.8  3298   35.9  46     4.1  3536   38.6  49     3.9  3560   35.5  50     3.8  3528   35.7  50     4.0  3571   32.6  50      
 41   4.0  4367                3.8  4651                3.8  4741                3.8  4740                4.0  4645                 
 42   3.8  3439   36.1  46     3.7  3672   39.2  49     3.9  3720   36.5  50     3.8  3699   35.8  50     3.9  3636   34.0  49      
 45   3.7  4582                3.8  4826                3.8  4922                3.6  4921                3.8  4827                 
 46   4.2  3147   37.1  46     3.3  3372   37.9  49     2.8  3454   34.5  50     3.1  3467   34.6  50     3.3  3409   32.4  49      
 49   3.7  4672                3.6  4975                3.6  5074                3.6  5070                3.6  4965                 
 50   4.4  3133   38.0  46     4.2  3370   40.0  49     4.1  3457   37.0  50     3.9  3478   36.1  50     3.8  3429   34.2  49      
 53   4.0  4379                3.8  4661                3.9  4751                3.8  4750                3.8  4647                 
 54   4.3  3298   39.4  46     4.4  3529   40.6  49     4.3  3623   37.5  50     4.1  3697   36.4  50     4.1  3642   35.0  49      
 57   4.0  4343                3.7  4630                3.7  4730                3.8  4731                3.8  4640                 
 58   4.5  3289   39.8  46     4.5  3511   41.4  49     4.0  3625   38.5  50     3.9  3636   37.2  50     3.8  3609   35.3  49      
 61   3.5  4451                3.4  4748                3.5  4733                3.3  4806                3.2  4729                 
 62   4.0  3051   39.9  46     4.0  3651   41.3  49     4.2  3679   39.0  49     4.1  3848   37.0  50     4.1  3763   35.6  49      
 65   3.6  4287                3.2  4476                3.3  4567                3.4  4680                3.7  4592                 
 66   4.3  3383   39.9  46     4.2  3559   41.1  48     4.0  3573   39.0  49     3.6  3610   37.1  50     3.6  3586   35.1  49      
 69   3.9  4359                3.7  4459                3.9  4652                3.6  4657                3.7  4662                 
 70   4.1  3347   42.2  46     3.9  3396   41.8  47     3.7  3518   39.2  49     3.6  3523   38.7  49     3.6  3511   35.6  49      
 73   2.3  4377                2.6  4466                2.5  4654                2.4  4653                2.6  4556                 
 74   4.3  3410   41.7  46     4.0  3505   42.1  47     4.2  3679   40.0  49     4.1  3699   38.3  49     3.9  3648   35.4  48      
 77   4.0  4282                4.2  4383                4.0  4576                3.8  4583                3.3  4398                 
 78   4.1  3346   43.9  46     3.8  3460   44.3  47     3.6  3642   41.5  49     3.4  3665   39.6  49     3.7  3539   36.4  47      
 81   3.9  4054                3.8  4429                3.6  4618                3.7  4621                3.7  4335                 
 82   4.0  2975   45.9  43     4.1  3273   46.7  47     3.7  3433   42.8  49     3.7  3453   41.3  49     3.6  3261   36.9  46      
 85   4.0  4072                4.1  4451                3.7  4645                3.6  4551                3.8  4274                 
 86   4.2  3106   47.4  43     4.3  3414   47.2  47     3.5  3579   43.4  49     3.7  3527   41.5  48     4.2  3327   37.5  45      
 89   4.5  5292                4.3  5046                4.3  5299                4.2  4996                4.0  4777                 
 90   5.5  1870   47.2  43     4.8  2801   46.5  47     4.6  2566   43.6  47     4.5  2912   41.4  47     4.4  2625   37.0  44      
 93   4.0  4134                4.0  4324                3.7  4519                3.8  4328                3.7  4128                 
 94   4.6  3049   47.2  43     4.9  3209   47.3  45     4.1  3367   43.8  47     4.2  3240   42.8  45     4.2  3111   37.6  43      
 97   4.4  3976                4.5  4268                4.1  4375                4.3  4274                4.2  3999                 
==================================================================================================================================  
                                                                                                                                   
                                                  DIAGNOSTIC TRAILER REPORT                                                         
                                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                               
                                                  CHRONIC DOSED FEED STUDY OF CITRAL                                                
==================================================================================================================================  
      UNTREAT CONTROL          VEHICLE CONTROL              500 PPM                  1000 PPM                 2000 PPM              
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS     
=================================================================================================================================== 
 98   4.8  2964   47.5  42     4.8  3153   48.0  44     4.6  3216   43.5  46     4.4  3153   42.5  45     4.7  2952   37.6  42      
101   4.4  4240                4.7  4343                4.3  4545                4.2  4541                4.3  4141                 
102   5.2  2792   45.9  42     5.3  2873   47.1  43     5.0  3017   42.9  45     4.8  3030   41.4  45     5.1  2724   36.6  40      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.2                     21.1                     20.9                     21.0                     20.4          
14 TO 52          33.4                     35.3                     33.1                     32.7                     30.7          
 > 52             43.7                     44.3                     41.1                     39.6                     36.3          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.