https://ntp.niehs.nih.gov/go/12931

TDMS Study 56348-04 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                       CITRAL                                                 DATE: 07/05/01  
EXPERIMENT: 56348 TEST: 04                                                                                        TIME: 13:40:02    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C56348      
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS LABORATORY                     CITRAL                                                      DATE: 07/05/01    
EXPERIMENT: 56348 TEST: 04                                                                                        TIME: 13:51:57    
SPECIES: MICE, B6C3F1                                                                                                               
TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  C56348      
CONT: N01-ES-55384                                                                                                CAS: 5392-40-5    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                         
                                                TWO YEAR DOSED FEED STUDY OF CITRAL                                                 
=================================================================================================================================== 
WEEK     UNTREAT CONTROL        VEHICLE CONTROL          500 PPM                  1000 PPM                 2000 PPM                 
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        21.6       50        21.7    100.5    50      21.8    100.9    50      21.7    100.5    50      21.7    100.5    50      
  1        21.6       50        21.7    100.5    50      21.8    100.9    50      21.7    100.5    50      21.7    100.5    50      
  2        22.0       50        22.3    101.4    50      22.4    101.8    50      21.8     99.1    50      21.5     97.7    50      
  6        25.9       50        26.8    103.5    50      26.5    102.3    50      26.0    100.4    50      25.4     98.1    50      
 10        29.5       50        30.4    103.1    50      30.1    102.0    50      29.2     99.0    50      28.1     95.3    50      
 14        31.9       50        32.9    103.1    50      32.4    101.6    50      31.6     99.1    50      30.5     95.6    50      
 18        33.8       50        34.2    101.2    50      34.0    100.6    50      33.4     98.8    50      32.3     95.6    50      
 22        35.6       50        36.4    102.2    49      35.9    100.8    50      34.6     97.2    50      33.7     94.7    50      
 26        37.4       50        38.3    102.4    49      37.6    100.5    50      36.3     97.1    50      35.7     95.5    50      
 30        39.4       50        40.4    102.5    49      39.6    100.5    50      38.6     98.0    50      37.2     94.4    50      
 34        40.8       50        42.3    103.7    49      41.0    100.5    50      40.1     98.3    50      38.2     93.6    50      
 38        42.4       50        43.4    102.4    49      42.2     99.5    50      40.9     96.5    50      39.1     92.2    50      
 42        42.9       50        43.4    101.2    49      42.6     99.3    50      41.6     97.0    50      40.0     93.2    50      
 46        42.6       50        43.9    103.1    48      43.1    101.2    50      41.7     97.9    50      39.9     93.7    50      
 50        43.5       50        45.1    103.7    48      44.0    101.1    50      42.7     98.2    50      40.6     93.3    50      
 54        44.1       50        44.9    101.8    48      43.5     98.6    50      42.6     96.6    50      40.4     91.6    50      
 58        43.9       49        45.3    103.2    48      44.0    100.2    50      42.0     95.7    50      40.6     92.5    50      
 62        43.1       49        44.9    104.2    48      43.9    101.9    48      42.2     97.9    49      40.2     93.3    50      
 66        43.8       49        44.7    102.1    48      44.5    101.6    48      42.8     97.7    49      40.4     92.2    48      
 70        45.2       49        44.6     98.7    48      44.5     98.5    48      43.6     96.5    49      40.6     89.8    48      
 74        45.8       49        45.6     99.6    48      45.8    100.0    46      44.1     96.3    49      41.2     90.0    47      
 78        46.2       49        48.2    104.3    46      46.4    100.4    46      44.8     97.0    49      41.5     89.8    47      
 82        47.2       49        49.6    105.1    46      46.8     99.2    46      45.3     96.0    49      42.0     89.0    47      
 86        47.4       49        49.5    104.4    46      46.9     98.9    45      45.7     96.4    49      41.3     87.1    47      
 90        45.4       49        47.6    104.8    46      45.2     99.6    44      44.0     96.9    48      39.8     87.7    46      
 94        45.6       48        47.9    105.0    45      45.0     98.7    42      43.4     95.2    47      40.1     87.9    43      
 98        45.5       48        47.0    103.3    45      44.9     98.7    41      42.9     94.3    47      39.7     87.3    42      
102        44.0       48        45.9    104.3    43      42.8     97.3    41      41.6     94.5    44      38.6     87.7    40      
TERM. SAC.            48                         43                       40                       42                       40      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                       
                                                TWO YEAR DOSED FEED STUDY OF CITRAL                                                 
=================================================================================================================================== 
WEEK     UNTREAT CONTROL        VEHICLE CONTROL          500 PPM                  1000 PPM                 2000 PPM                 
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        17.9       50        17.6     98.3    50      17.7     98.9    50      17.8     99.4    50      17.6     98.3    50      
  1        17.9       50        17.6     98.3    50      17.7     98.9    50      17.8     99.4    50      17.6     98.3    50      
  2        18.3       50        18.2     99.5    50      18.1     98.9    50      18.3    100.0    50      17.9     97.8    50      
  6        22.7       49        22.5     99.1    50      22.5     99.1    50      22.4     98.7    50      21.7     95.6    50      
 10        25.7       49        26.1    101.6    50      25.3     98.4    50      25.4     98.8    50      24.6     95.7    50      
 14        28.1       49        28.3    100.7    50      27.8     98.9    50      26.6     94.7    50      25.7     91.5    50      
 18        29.2       49        31.2    106.8    49      29.8    102.1    50      29.2    100.0    50      27.9     95.5    50      
 22        28.8       49        31.0    107.6    49      29.8    103.5    50      29.1    101.0    50      27.8     96.5    50      
 26        31.5       49        33.4    106.0    49      31.6    100.3    50      31.6    100.3    50      29.5     93.7    50      
 30        33.5       49        35.4    105.7    49      33.4     99.7    50      33.4     99.7    50      31.0     92.5    50      
 34        35.6       49        37.8    106.2    49      35.1     98.6    50      35.3     99.2    50      31.9     89.6    50      
 38        35.9       46        38.6    107.5    49      35.5     98.9    50      35.7     99.4    50      32.6     90.8    50      
 42        36.1       46        39.2    108.6    49      36.5    101.1    50      35.8     99.2    50      34.0     94.2    49      
 46        37.1       46        37.9    102.2    49      34.5     93.0    50      34.6     93.3    50      32.4     87.3    49      
 50        38.0       46        40.0    105.3    49      37.0     97.4    50      36.1     95.0    50      34.2     90.0    49      
 54        39.4       46        40.6    103.0    49      37.5     95.2    50      36.4     92.4    50      35.0     88.8    49      
 58        39.8       46        41.4    104.0    49      38.5     96.7    50      37.2     93.5    50      35.3     88.7    49      
 62        39.9       46        41.3    103.5    49      39.0     97.7    49      37.0     92.7    50      35.6     89.2    49      
 66        39.9       46        41.1    103.0    48      39.0     97.7    49      37.1     93.0    50      35.1     88.0    49      
 70        42.2       46        41.8     99.1    47      39.2     92.9    49      38.7     91.7    49      35.6     84.4    49      
 74        41.7       46        42.1    101.0    47      40.0     95.9    49      38.3     91.8    49      35.4     84.9    48      
 78        43.9       46        44.3    100.9    47      41.5     94.5    49      39.6     90.2    49      36.4     82.9    47      
 82        45.9       43        46.7    101.7    47      42.8     93.2    49      41.3     90.0    49      36.9     80.4    46      
 86        47.4       43        47.2     99.6    47      43.4     91.6    49      41.5     87.6    48      37.5     79.1    45      
 90        47.2       43        46.5     98.5    47      43.6     92.4    47      41.4     87.7    47      37.0     78.4    44      
 94        47.2       43        47.3    100.2    45      43.8     92.8    47      42.8     90.7    45      37.6     79.7    43      
 98        47.5       42        48.0    101.1    44      43.5     91.6    46      42.5     89.5    45      37.6     79.2    42      
102        45.9       42        47.1    102.6    43      42.9     93.5    45      41.4     90.2    45      36.6     79.7    40      
TERM. SAC.            40                         41                       45                       43                       40      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.