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TDMS Study 56348-04 Pathology Tables

NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01
Route: DOSED FEED                                                                                                 Time: 13:47:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  5392-40-5

       Lock Date:  03/25/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Natural Death                                      5            3            3            3            5                        
    Moribund Sacrifice                                 4            5            2            4            5                        
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           41           45           43           40                        
  Missing                                                           1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           49           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (49)         (50)         (50)         (50)                      
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)         (50)                      
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (50)         (50)         (50)                      
      Carcinoma                                                                  1 (2%)                    1 (2%)                   
   Intestine Small, Ileum                             (50)         (49)         (50)         (50)         (50)                      
   Liver                                              (50)         (49)         (50)         (50)         (50)                      
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma                         1 (2%)       2 (4%)       1 (2%)       1 (2%)       1 (2%)                   
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                           5 (10%)      2 (4%)       2 (4%)       8 (16%)      7 (14%)                  
      Hepatocellular Adenoma, Multiple                              1 (2%)                                 1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Mesentery                                          (5)          (3)          (1)          (6)          (2)                       
      Fibrous Histiocytoma                                                                    1 (17%)                               
      Sarcoma, Metastatic, Skin                                                               1 (17%)                               
   Pancreas                                           (50)         (49)         (50)         (50)         (50)                      
   Salivary Glands                                    (49)         (49)         (50)         (50)         (49)                      
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                              2 (4%)                   
   Stomach, Glandular                                 (50)         (49)         (50)         (50)         (50)                      
      Adenoma                                                                    1 (2%)                                             
   Tongue                                                          (1)                                    (1)                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma                                       1 (100%)                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)         (50)                      
   Adrenal Medulla                                    (50)         (49)         (50)         (50)         (50)                      
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Pituitary Gland                                    (49)         (48)         (50)         (49)         (49)                      
      Pars Distalis, Adenoma                           4 (8%)       4 (8%)       5 (10%)      2 (4%)       3 (6%)                   
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (48)         (49)         (50)         (50)         (49)                      
      Follicle, Adenoma                                                          1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (48)         (50)         (47)         (49)                      
      Carcinoma                                        1 (2%)                                                                       
   Ovary                                              (50)         (49)         (50)         (49)         (50)                      
      Carcinoma, Metastatic, Stomach, Forestomach                                             1 (2%)                                
      Cystadenoma                                      1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Luteoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Uterus                                             (50)         (49)         (50)         (50)         (50)                      
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Leiomyosarcoma                                                                                       1 (2%)                   
      Polyp Stromal                                                 2 (4%)       1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)         (50)                      
   Lymph Node                                         (2)          (1)                       (7)          (5)                       
      Lumbar, Histiocytic Sarcoma                                                                          1 (20%)                  
      Mediastinal, Histiocytic Sarcoma                                                                     1 (20%)                  
      Mediastinal, Sarcoma, Metastatic, Skin                                                  1 (14%)                               
      Renal, Histiocytic Sarcoma                                                                           1 (20%)                  
   Lymph Node, Mandibular                             (49)         (49)         (48)         (47)         (44)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Lymph Node, Mesenteric                             (49)         (47)         (48)         (50)         (49)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Spleen                                             (50)         (49)         (50)         (49)         (50)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Thymus                                             (47)         (48)         (49)         (48)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (49)         (49)                      
      Carcinoma                                                                  1 (2%)                                             
   Skin                                               (50)         (49)         (50)         (50)         (50)                      
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Sebaceous Gland, Adenoma                                                   1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  2 (4%)       2 (4%)       1 (2%)       2 (4%)                   
      Tail, Sarcoma                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)         (50)                      
      Fibrosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)                       (1)          (2)                       
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       7 (14%)      3 (6%)       1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       3 (6%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Nose                                               (50)         (49)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (2)          (3)          (1)                       
      Adenoma                                          1 (50%)      2 (67%)      1 (50%)      2 (67%)      1 (100%)                 
      Carcinoma                                        1 (50%)                                1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)         (50)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Urinary Bladder                                    (50)         (49)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(49)        *(50)        *(50)        *(50)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Lymphoma Malignant                               4 (8%)       3 (6%)       5 (10%)      9 (18%)     12 (24%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            23          22          27          23          30                           
     Total Primary Neoplasms                           32          28          36          34          36                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          12          19          13          14                           
     Total Benign Neoplasms                            19          16          22          16          17                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              12          12          13          13          18                           
     Total Malignant Neoplasms                         13          12          14          18          19                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                       2                                       
     Total Metastatic Neoplasm                          2           2                       6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            4            2            6            3                        
    Natural Death                                      1            3            8            2            7                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           42           40           42           40                        
    Natural Death                                      1                                                                            
    Accidently Killed                                               1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)         (50)                      
      Polyp Adenomatous                                1 (2%)       1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Carcinoma                                        1 (2%)       2 (4%)                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hemangiosarcoma                                  2 (4%)                                                                       
      Hepatocellular Carcinoma                         3 (6%)       9 (18%)     12 (24%)      4 (8%)       9 (18%)                  
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           9 (18%)      8 (16%)      8 (16%)     11 (22%)     10 (20%)                  
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (4%)       3 (6%)                    3 (6%)                   
   Mesentery                                          (6)          (3)          (2)          (3)          (3)                       
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Carcinoma                                                                               1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (50)         (50)                      
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Subcapsular, Adenoma                             1 (2%)       1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (49)         (50)         (50)         (50)         (50)                      
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (49)         (47)         (50)                      
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (50)         (50)                      
   Prostate                                           (50)         (50)         (50)         (50)         (50)                      
   Seminal Vesicle                                    (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)         (50)                      
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                                                      1 (2%)                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Hemangiosarcoma                                                                         2 (4%)       1 (2%)                   
      Mast Cell Tumor Malignant                                     1 (2%)                    1 (2%)                                
   Lymph Node                                         (2)                       (1)          (2)          (1)                       
      Mediastinal, Carcinoma, Metastatic, Pancreas                                            1 (50%)                               
   Lymph Node, Mandibular                             (48)         (45)         (47)         (47)         (49)                      
   Lymph Node, Mesenteric                             (48)         (47)         (49)         (48)         (50)                      
   Spleen                                             (50)         (50)         (49)         (50)         (50)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                                                         3 (6%)       2 (4%)                   
      Mast Cell Tumor Malignant                                     1 (2%)                                                          
   Thymus                                             (50)         (49)         (48)         (48)         (46)                      
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Pinna, Melanoma Malignant                                                                            1 (2%)                   
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
      Tail, Fibrosarcoma                                            1 (2%)                    1 (2%)                                
      Tail, Neurofibrosarcoma                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Chondrosarcoma                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Astrocytoma Benign                                                                                   1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Alveolar/Bronchiolar Adenoma                     4 (8%)       8 (16%)      5 (10%)      6 (12%)      2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       5 (10%)      4 (8%)       1 (2%)       3 (6%)                   
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       1 (2%)       1 (2%)       2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (2)          (1)          (3)                                    
      Adenoma                                          2 (100%)     2 (100%)     1 (100%)     2 (67%)                               
      Carcinoma                                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
   Urinary Bladder                                    (50)         (50)         (49)         (50)         (50)                      
      Hemangioma                                                                              1 (2%)                                
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Lymphoma Malignant                               4 (8%)                    2 (4%)       3 (6%)       1 (2%)                   
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 56348-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               CITRAL                                          Date: 07/05/01  
Route: DOSED FEED                                                                                                 Time: 13:47:25  
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         B6C3F1 MICE MALE                          UNTREAT      VEHICLE      500 PPM      1000 PPM     2000 PPM                     
                                                   CONTROL      CONTROL                                                             
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27          28          35          33          26                           
     Total Primary Neoplasms                           37          43          39          44          35                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          20          18          21          14                           
     Total Benign Neoplasms                            22          23          19          23          16                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          18          20          17          18                           
     Total Malignant Neoplasms                         15          20          20          21          19                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1           2           2                           
     Total Metastatic Neoplasm                                      1           2           7           2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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