Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/13060

TDMS Study 61427-07 Pathology Tables

NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48

                                                          FINAL#2/RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  1314-62-1

       Lock Date:  08/18/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           20           17           15                                     
    Natural Death                                      3            6            4            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           24           29           30                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Periesophageal Tissue, Inflammation, Chronic                                                                                  
          Active                                       1 [2.0]                                                                      
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [3.0]      1 [1.0]                   2 [2.5]                               
      Basophilic Focus                                 2                                                                            
      Basophilic Focus, Multiple                                    2            2                                                  
      Bile Stasis                                      1 [3.0]                                                                      
      Clear Cell Focus                                 1            4            7            4                                     
      Clear Cell Focus, Multiple                                                 2            1                                     
      Hepatodiaphragmatic Nodule                       9            9           10           13                                     
      Inflammation, Granulomatous                                   1 [2.0]                                                         
      Vacuolization Cytoplasmic                        6 [3.3]      8 [2.9]      5 [2.8]      7 [2.3]                               
      Bile Duct, Dilatation                                                                   1 [4.0]                               
      Bile Duct, Hyperplasia                           1 [2.0]      2 [1.5]      1 [3.0]      1 [2.0]                               
      Hepatocyte, Degeneration, Cystic                                                        1 [2.0]                               
      Hepatocyte, Necrosis                                                       1 [3.0]      1 [3.0]                               
      Hepatocyte, Regeneration                         1 [3.0]                                                                      
      Portal, Inflammation, Chronic Active                                                    1 [2.0]                               
      Portal, Pigmentation                                          2 [2.5]                   1 [3.0]                               
      Serosa, Fibrosis                                                           1 [1.0]      1 [2.0]                               
   Mesentery                                          (9)          (20)         (22)         (15)                                   
      Hemorrhage                                                                 1 [3.0]                                            
      Artery, Inflammation                             1 [4.0]                                                                      
      Fat, Necrosis                                    9 [2.7]     20 [2.6]     17 [2.5]     15 [2.9]                               
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Acinus, Atrophy                                  2 [2.0]                   1 [3.0]                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Erosion                                                                    1 [3.0]                                            
      Hyperkeratosis                                                                          1 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Suppurative                        1 [2.0]                                2 [3.0]                               
      Ulcer                                            5 [3.6]      5 [3.8]      1 [3.0]      1 [3.0]                               
      Epithelium, Hyperplasia                                                    2 [2.0]      2 [2.5]                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Cyst                                             1 [3.0]                                                                      
      Erosion                                          1 [4.0]                   1 [2.0]                                            
      Inflammation, Suppurative                        1 [1.0]                                                                      
      Epithelium, Hyperplasia                                                                 1 [1.0]                               
   Tongue                                                          (2)          (4)          (2)                                    
      Epithelium, Hyperkeratosis                                                 3 [1.3]                                            
      Epithelium, Hyperplasia                                                                 2 [2.5]                               
   Tooth                                              (3)          (2)          (2)          (1)                                    
      Peridontal Tissue, Inflammation, Suppurative     3 [2.7]      1 [2.0]      1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Inflammation                                     1 [4.0]                                                                      
      Mineralization                                                1 [4.0]                                                         
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                   3 [2.0]      1 [1.0]      1 [2.0]      2 [1.5]                               
      Ventricle, Thrombosis                                         1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 [1.0]      1 [3.0]                   1 [3.0]                               
      Necrosis                                                      2 [2.5]      1 [1.0]      1 [4.0]                               
      Vacuolization Cytoplasmic                        9 [2.0]      7 [2.0]      4 [1.8]      3 [2.3]                               
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 [2.0]                                                         
      Hyperplasia                                      2 [3.5]      2 [2.0]      1 [3.0]      5 [2.6]                               
      Necrosis                                                                                1 [4.0]                               
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 [2.0]                                1 [2.0]                               
   Parathyroid Gland                                  (45)         (47)         (49)         (50)                                   
      Hyperplasia                                                   1 [2.0]                                                         
   Pituitary Gland                                    (49)         (50)         (49)         (50)                                   
      Angiectasis                                                   1 [4.0]                                                         
      Cyst                                             4 [3.5]      3 [4.0]      1 [2.0]      3 [3.3]                               
      Hemorrhage                                       1 [4.0]                   3 [3.7]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pigmentation                                                  1 [3.0]                                                         
      Pars Distalis, Cyst                                                                     1 [2.0]                               
      Pars Distalis, Hyperplasia                      12 [3.1]      6 [2.5]     16 [2.8]      4 [3.0]                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              6 [1.7]      5 [1.6]      2 [1.5]      5 [2.0]                               
      Follicular Cell, Hyperplasia                                               1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (49)         (50)                                   
      Cyst                                             1 [4.0]      3 [3.7]      1 [2.0]      1 [3.0]                               
      Hyperplasia                                      2 [3.5]      3 [3.3]                   2 [2.5]                               
      Inflammation, Chronic                                                                   1 [3.0]                               
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 [4.0]                   1 [3.0]                                            
      Cyst                                             4 [2.8]     10 [3.0]      7 [2.3]     12 [2.8]                               
      Inflammation, Chronic                                         1 [3.0]                   1 [3.0]                               
      Inflammation, Granulomatous                                   1 [2.0]                                                         
      Follicle, Cyst                                   2 [2.5]      1 [3.0]      1 [3.0]                                            
      Granulosa Cell, Hyperplasia                                                             1 [3.0]                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hydrometra                                       1 [3.0]                                                                      
      Necrosis                                                                   1 [4.0]                                            
      Endometrium, Hyperplasia                                      1 [2.0]      4 [2.3]      4 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia, Megakaryocyte                       1 [4.0]                                                                      
      Myelofibrosis                                                 1 [2.0]      1 [2.0]                                            
   Lymph Node                                         (3)          (3)          (3)          (2)                                    
      Iliac, Ectasia                                                                          1 [4.0]                               
      Pancreatic, Pigmentation                                      1 [3.0]                                                         
   Lymph Node, Bronchial                              (42)         (45)         (44)         (44)                                   
      Pigmentation                                    16 [1.2]      6 [1.3]      8 [1.3]      5 [1.2]                               
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis                                                                   1 [4.0]                                            
      Hemorrhage                                       1 [2.0]                                                                      
   Lymph Node, Mediastinal                            (48)         (50)         (50)         (48)                                   
      Angiectasis                                                   1 [3.0]                                                         
      Hyperplasia, Lymphoid                                         1 [3.0]                                                         
      Pigmentation                                    26 [1.3]     14 [1.1]     20 [1.1]     24 [1.2]                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 3            1                                                               
      Fibrosis                                         2 [2.5]      3 [3.0]      1 [3.0]                                            
      Hematopoietic Cell Proliferation                 1 [4.0]                                2 [3.5]                               
      Hemorrhage                                                    3 [3.3]                                                         
      Necrosis                                                                   1 [4.0]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                      5 [3.0]      2 [1.0]      4 [1.5]      6 [2.8]                               
      Epithelium, Hyperplasia                          3 [2.0]                                                                      
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 [4.0]                   1 [3.0]                               
      Hyperkeratosis                                                             1 [2.0]                                            
      Inflammation, Acute                                           1 [4.0]                                                         
      Inflammation, Chronic                                                                   1 [3.0]                               
      Inflammation, Suppurative                        1 [2.0]                                                                      
      Ulcer                                                         1 [3.0]      1 [3.0]      1 [3.0]                               
      Hair Follicle, Atrophy                                                                  1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  1 [3.0]                   1 [3.0]                               
   Skeletal Muscle                                    (2)          (2)                       (2)                                    
      Degeneration                                                  1 [2.0]                                                         
      Fibrosis                                                      1 [3.0]                                                         
      Inflammation, Chronic Active                     1 [4.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      1 [3.0]                                1 [4.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Hemorrhage                                       3 [3.3]      6 [2.8]      3 [1.3]                                            
      Thrombosis                                                                              1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (50)                                   
      Foreign Body                                     3            6                         1                                     
      Hemorrhage                                                                 1 [1.0]      1 [2.0]                               
      Inflammation, Chronic                            8 [1.8]     26 [1.5]     27 [1.3]     37 [1.4]                               
      Inflammation, Suppurative                        5 [1.4]      2 [1.5]      3 [1.3]      2 [2.5]                               
      Ulcer                                                                                   1 [2.0]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Degeneration                                 2 [1.0]     33 [1.2]     26 [1.2]     40 [1.5]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Hyperplasia                                              25 [1.4]     26 [1.3]     33 [1.5]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Metaplasia, Squamous                         2 [2.0]      7 [1.9]      7 [1.7]     16 [1.4]                               
   Lung                                               (49)         (49)         (50)         (50)                                   
      Edema                                            1 [4.0]                                                                      
      Hemorrhage                                       1 [2.0]      1 [2.0]                                                         
      Inflammation                                                                            1 [2.0]                               
      Inflammation, Chronic Active                    10 [1.5]     10 [1.1]     14 [1.2]     40 [1.7]                               
      Inflammation, Suppurative                        2 [1.5]                                                                      
      Alveolar Epithelium, Hyperplasia                 4 [1.0]      8 [1.8]     21 [1.2]     50 [3.1]                               
      Alveolar Epithelium, Metaplasia, Squamous                                               6 [3.0]                               
      Alveolar Epithelium, Regeneration                                                       1 [3.0]                               
      Alveolus, Infiltration Cellular, Histiocyte     26 [1.4]     35 [1.3]     44 [2.0]     50 [3.1]                               
      Alveolus, Pigmentation                           1 [1.0]      1 [1.0]      8 [1.3]      7 [1.9]                               
      Artery, Mineralization                           1 [4.0]                                                                      
      Bronchiole, Foreign Body                         1                                                                            
      Bronchiole, Hyperplasia                          6 [1.5]      5 [1.6]     14 [1.3]     48 [3.0]                               
      Bronchiole, Inflammation, Suppurative            1 [3.0]                                                                      
      Bronchiole, Metaplasia, Squamous                                                        1 [2.0]                               
      Interstitium, Fibrosis                          19 [1.4]      7 [1.3]     12 [1.6]     32 [1.4]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     3            4            1            2                                     
      Inflammation, Chronic                            1 [1.0]                                                                      
      Inflammation, Suppurative                        3 [2.3]      6 [2.2]      5 [1.8]     10 [1.8]                               
      Goblet Cell, Respiratory Epithelium,                                                                                          
          Hyperplasia                                 13 [2.0]     18 [2.0]     16 [1.9]     30 [2.0]                               
      Nasolacrimal Duct, Inflammation, Suppurative     2 [2.5]      4 [1.3]      2 [2.5]      7 [2.0]                               
      Olfactory Epithelium, Degeneration, Hyaline     16 [1.1]     20 [1.3]      6 [1.7]      4 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                      CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Hyperplasia              1 [2.0]      2 [2.5]      1 [2.0]      2 [1.5]                               
      Respiratory Epithelium, Metaplasia, Squamous                               2 [2.5]      1 [2.0]                               
      Respiratory Epithelium, Ulcer                                                           1 [3.0]                               
   Pleura                                             (3)                                                                           
      Inflammation, Chronic                            3 [1.3]                                                                      
   Trachea                                            (50)         (50)         (49)         (50)                                   
      Foreign Body                                                                            1                                     
      Inflammation, Chronic                                         1 [1.0]                                                         
      Inflammation, Suppurative                                                               1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                       (2)          (3)                                    
      Lens, Cataract                                   3 [3.0]                                3 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Accumulation, Hyaline Droplet                                 1 [4.0]                                                         
      Nephropathy, Chronic                            24 [1.4]     21 [1.4]     20 [1.3]     32 [1.7]                               
      Thrombosis                                                    1 [2.0]                                                         
      Cortex, Renal Tubule, Necrosis                   1 [1.0]                   1 [4.0]                                            
      Papilla, Mineralization                                                    1 [3.0]      2 [2.0]                               
      Pelvis, Dilatation                               1 [4.0]                                                                      
      Renal Tubule, Mineralization                                               1 [2.0]                                            
      Renal Tubule, Vacuolization Cytoplasmic                                                 1 [4.0]                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Transitional Epithelium, Hyperplasia                          1 [2.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           17           18           13                                     
    Natural Death                                      5            4            6           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           29           26           27                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (47)         (49)         (47)         (48)                                   
      Thrombosis                                                                 1 [3.0]                                            
   Intestine Small, Duodenum                          (47)         (49)         (46)         (48)                                   
      Inflammation, Suppurative                        1 [2.0]                                                                      
   Liver                                              (50)         (50)         (49)         (50)                                   
      Basophilic Focus                                              1                         1                                     
      Bile Stasis                                                                             1 [3.0]                               
      Clear Cell Focus                                 3            2            1            7                                     
      Hepatodiaphragmatic Nodule                       5            8            7           14                                     
      Inflammation, Granulomatous                                                             2 [2.0]                               
      Mixed Cell Focus                                                                        1                                     
      Thrombosis                                                                              1 [3.0]                               
      Vacuolization Cytoplasmic                        5 [3.2]      4 [2.0]      8 [2.6]      5 [2.8]                               
      Bile Duct, Dilatation                                                                   1 [4.0]                               
      Bile Duct, Hyperplasia                          11 [1.8]      8 [1.6]      8 [1.5]     14 [2.0]                               
      Hepatocyte, Degeneration, Cystic                              3 [2.0]      2 [4.0]                                            
      Hepatocyte, Necrosis                                          1 [4.0]      1 [3.0]                                            
      Hepatocyte, Regeneration                         1 [4.0]      1 [4.0]      2 [3.5]                                            
      Portal, Inflammation, Chronic Active             4 [1.8]                   1 [1.0]      4 [1.8]                               
      Portal, Pigmentation                                                                    3 [3.3]                               
      Serosa, Inflammation, Suppurative                1 [4.0]                                                                      
   Mesentery                                          (8)          (18)         (12)         (9)                                    
      Hemorrhage                                       1 [3.0]      1 [3.0]      1 [2.0]                                            
      Artery, Inflammation                                                                    1 [4.0]                               
      Fat, Hemorrhage                                               1 [2.0]                                                         
      Fat, Necrosis                                    7 [2.4]     16 [2.9]      9 [2.2]      8 [3.0]                               
   Oral Mucosa                                                     (3)                       (4)                                    
      Inflammation, Suppurative                                                               1 [2.0]                               
      Pharyngeal, Hyperplasia, Squamous                                                       1 [4.0]                               
      Pharyngeal, Ulcer                                                                       1 [4.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Infiltration Cellular, Lipocyte                                                         1 [3.0]                               
      Acinus, Atrophy                                  3 [2.0]                   4 [1.8]      1 [3.0]                               
      Acinus, Hyperplasia                                                                     3 [2.3]                               
      Artery, Inflammation                                                                    2 [4.0]                               
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Cyst                                                                                    1 [4.0]                               
      Diverticulum                                     1                                      2                                     
      Hyperkeratosis                                   1 [3.0]                                                                      
      Inflammation, Suppurative                        1 [4.0]      1 [3.0]                   1 [4.0]                               
      Necrosis                                                                                1 [4.0]                               
      Ulcer                                            3 [3.7]      3 [3.3]      4 [3.5]      3 [3.0]                               
      Arteriole, Necrosis                                           1 [3.0]                                                         
      Epithelium, Hyperplasia                          1 [3.0]                   3 [2.3]      2 [3.0]                               
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Erosion                                          1 [4.0]                   1 [2.0]                                            
      Inflammation, Suppurative                        1 [4.0]                                                                      
      Necrosis                                         2 [2.5]      1 [3.0]      2 [2.0]      1 [1.0]                               
   Tongue                                                                       (1)          (2)                                    
      Epithelium, Hyperplasia                                                    1 [2.0]      1 [3.0]                               
   Tooth                                              (7)          (1)          (2)          (5)                                    
      Peridontal Tissue, Inflammation, Suppurative     7 [2.1]      1 [3.0]      2 [2.5]      4 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (49)         (50)                                   
      Aorta, Thrombosis                                                                       1 [4.0]                               
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   7 [1.4]      7 [1.6]      7 [1.6]      7 [2.3]                               
      Atrium, Thrombosis                               2 [2.5]                   2 [3.5]                                            
      Pericardium, Fibrosis                                                      1 [1.0]                                            
      Valve, Hemorrhage                                1 [3.0]                                                                      
      Ventricle, Hypertrophy                           1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Angiectasis                                                   1 [4.0]                                                         
      Hemorrhage                                                                              1 [3.0]                               
      Hyperplasia                                      1 [1.0]                                1 [2.0]                               
      Necrosis                                         1 [4.0]                                1 [2.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic                        9 [1.9]      5 [1.6]      7 [2.6]      5 [2.2]                               
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                     16 [2.1]      8 [2.4]     12 [3.0]     10 [2.7]                               
      Necrosis                                         1 [4.0]                                                                      
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                   1 [3.0]      1 [2.0]      1 [2.0]                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 [4.0]                   1 [4.0]                               
      Hemorrhage                                       3 [4.0]      1 [4.0]                   1 [4.0]                               
      Pars Distalis, Hyperplasia                       2 [2.5]      5 [3.0]      5 [3.2]      4 [3.8]                               
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      C-Cell, Hyperplasia                              9 [2.2]      4 [2.0]      4 [2.8]      7 [1.4]                               
      Follicular Cell, Hyperplasia                                               2 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Inflammation, Granulomatous                      1 [3.0]                                                                      
      Spermatocele                                                               1 [3.0]                                            
   Penis                                              (2)                       (3)                                                 
      Hyperplasia, Squamous                                                      1 [4.0]                                            
      Necrosis                                         1 [4.0]                   1 [4.0]                                            
   Preputial Gland                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 [3.0]      1 [3.0]                   2 [3.5]                               
      Inflammation, Chronic                            3 [3.0]                   1 [4.0]                                            
   Prostate                                           (50)         (50)         (49)         (50)                                   
      Fibrosis                                         1 [4.0]                                                                      
      Hyperplasia                                      1 [1.0]      2 [1.5]      3 [1.0]                                            
      Inflammation, Granulomatous                                                1 [3.0]                                            
      Inflammation, Suppurative                       12 [2.8]      8 [1.9]      8 [2.9]      6 [2.5]                               
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                                1 [2.0]                                            
      Inflammation, Granulomatous                                                             1 [3.0]                               
      Inflammation, Suppurative                                                  1 [4.0]      2 [2.5]                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                     1 [3.0]                                                         
      Necrosis                                                      1 [4.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Artery, Inflammation                                                       2 [2.0]                                            
      Germinal Epithelium, Atrophy                     6 [3.5]      6 [3.8]     13 [3.6]     10 [3.8]                               
      Interstitial Cell, Hyperplasia                   2 [2.5]      7 [2.4]      5 [2.2]      3 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                         1 [3.0]                   1 [3.0]                               
      Myelofibrosis                                    1 [3.0]                                                                      
   Lymph Node                                         (2)          (3)          (2)          (5)                                    
      Inflammation, Granulomatous                                                             1 [3.0]                               
      Pancreatic, Pigmentation                                                                1 [3.0]                               
   Lymph Node, Bronchial                              (39)         (44)         (47)         (44)                                   
      Fibrosis                                                      1 [2.0]                                                         
      Pigmentation                                     8 [1.4]      8 [1.3]      3 [1.3]     12 [1.6]                               
   Lymph Node, Mandibular                             (44)         (48)         (46)         (45)                                   
      Ectasia                                                                    1 [3.0]                                            
      Hyperplasia, Lymphoid                                                                   1 [3.0]                               
      Inflammation, Acute                                           1 [3.0]      1 [3.0]      1 [2.0]                               
   Lymph Node, Mediastinal                            (45)         (47)         (46)         (44)                                   
      Angiectasis                                                                             1 [4.0]                               
      Inflammation, Granulomatous                                                             2 [3.5]                               
      Pigmentation                                    17 [1.4]     15 [1.3]     17 [1.5]     17 [1.8]                               
   Spleen                                             (50)         (50)         (48)         (50)                                   
      Accessory Spleen                                 1                         1                                                  
      Fibrosis                                         7 [2.9]     16 [2.9]     12 [2.5]     11 [2.7]                               
      Hematopoietic Cell Proliferation                 4 [3.3]                                                                      
      Hemorrhage                                       8 [3.9]      4 [3.5]      1 [4.0]                                            
      Necrosis                                                      2 [4.0]      1 [4.0]      1 [4.0]                               
      Pigmentation                                     1 [3.0]      1 [4.0]                                                         
   Thymus                                             (49)         (49)         (49)         (50)                                   
      Hemorrhage                                                                              1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (49)         (50)                                   
      Galactocele                                      2 [3.5]      1 [3.0]      5 [2.6]      4 [2.3]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst                                             2 [4.0]      1 [4.0]      1 [3.0]      6 [3.8]                               
      Cyst, Multiple                                                             1 [4.0]                                            
      Hyperkeratosis                                   4 [3.3]      2 [2.5]      3 [2.7]      3 [3.3]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hyperplasia                                                                1 [2.0]                                            
      Inflammation, Acute                                                        1 [3.0]                                            
      Ulcer                                                                      1 [4.0]                                            
      Hair Follicle, Atrophy                                                                  1 [2.0]                               
      Subcutaneous Tissue, Edema                                                 1 [3.0]                                            
      Subcutaneous Tissue, Fibrosis                                              1 [1.0]                                            
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                1 [2.0]      1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Vertebra, Fracture                               1                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Hemorrhage                                       5 [3.0]      3 [3.3]      2 [2.5]      4 [3.5]                               
      Hydrocephalus                                                 1 [4.0]                                                         
      Necrosis                                         1 [3.0]      1 [2.0]                                                         
      Medulla, Demyelination, Focal                                 1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (50)         (50)         (49)                                   
      Foreign Body                                     3            3            2            2                                     
      Hyperkeratosis                                                             1 [2.0]                                            
      Inflammation, Chronic                            3 [1.0]     20 [1.1]     17 [1.5]     28 [1.6]                               
      Inflammation, Suppurative                       11 [1.5]      3 [2.3]      4 [2.5]     13 [2.1]                               
      Respiratory Epithelium, Ulcer                                                           1 [3.0]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Degeneration                                             22 [1.1]     23 [1.1]     33 [1.5]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Hyperplasia                                              18 [1.5]     34 [1.5]     32 [1.9]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Metaplasia, Squamous                                      9 [1.7]     16 [1.8]     19 [2.1]                               
   Lung                                               (50)         (49)         (48)         (50)                                   
      Hemorrhage                                       5 [2.8]      1 [2.0]      2 [2.0]      1 [3.0]                               
      Inflammation, Chronic Active                     5 [1.6]      8 [1.8]     24 [1.3]     42 [2.4]                               
      Inflammation, Suppurative                                     2 [3.5]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Metaplasia                                                                              1 [1.0]                               
      Mineralization                                                2 [1.5]                   1 [1.0]                               
      Alveolar Epithelium, Hyperplasia                 7 [2.3]     24 [2.0]     34 [2.0]     49 [3.3]                               
      Alveolar Epithelium, Metaplasia, Squamous        1 [1.0]                               21 [3.6]                               
      Alveolus, Infiltration Cellular, Histiocyte     22 [1.3]     40 [2.0]     45 [2.3]     50 [3.3]                               
      Alveolus, Pigmentation                           1 [2.0]                   2 [1.5]     28 [2.1]                               
      Artery, Mineralization                                                                  1 [3.0]                               
      Bronchiole, Hyperplasia                          3 [2.3]     17 [2.2]     31 [1.8]     49 [3.3]                               
      Bronchiole, Metaplasia, Squamous                                                        7 [3.7]                               
      Interstitium, Edema                                                        1 [2.0]                                            
      Interstitium, Fibrosis                           7 [1.4]      7 [2.0]     16 [1.6]     38 [2.1]                               
      Mediastinum, Hemorrhage                                                                 1 [4.0]                               
   Nose                                               (49)         (50)         (49)         (48)                                   
      Foreign Body                                     3            5            1            1                                     
      Inflammation, Chronic                            1 [1.0]      1 [2.0]                                                         
      Inflammation, Suppurative                        8 [2.1]      7 [2.0]      3 [1.7]     11 [2.2]                               
      Goblet Cell, Respiratory Epithelium,                                                                                          
          Hyperplasia                                  4 [1.8]     15 [1.8]     12 [2.0]     17 [2.1]                               
      Nasolacrimal Duct, Inflammation, Suppurative     1 [3.0]      2 [2.0]                                                         
      Olfactory Epithelium, Degeneration, Hyaline      9 [1.2]      3 [1.7]      1 [2.0]      4 [1.3]                               
      Respiratory Epithelium, Degeneration, Hyaline                 1 [1.0]                                                         
      Respiratory Epithelium, Hyperplasia              2 [2.0]      1 [2.0]      1 [1.0]      3 [3.0]                               
      Respiratory Epithelium, Metaplasia, Squamous                  3 [2.0]      1 [1.0]      3 [1.3]                               
      Respiratory Epithelium, Mineralization           1 [2.0]                                                                      
   Pleura                                                                       (2)          (1)                                    
      Inflammation                                                               1 [1.0]                                            
   Trachea                                            (50)         (50)         (49)         (50)                                   
      Foreign Body                                                  1                                                               
      Inflammation, Suppurative                        1 [3.0]                                                                      
      Epithelium, Degeneration                                                                1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)          (2)          (3)                                    
      Atrophy                                          1 [4.0]      1 [1.0]                   1 [4.0]                               
      Lens, Cataract                                                2 [1.5]      1 [2.0]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Accumulation, Hyaline Droplet                    1 [4.0]                                1 [4.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:03:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                        CONTROL      0.5          1.0          2.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infarct                                                       1 [4.0]      1 [4.0]                                            
      Infiltration Cellular, Lipocyte                                            1 [4.0]                                            
      Nephropathy, Chronic                            37 [2.4]     42 [2.1]     46 [2.1]     47 [2.3]                               
      Cortex, Cyst                                     2 [3.5]                                                                      
      Pelvis, Dilatation                               1 [1.0]                                                                      
      Renal Tubule, Pigmentation                       1 [3.0]                   1 [4.0]                                            
   Urethra                                                                      (1)                                                 
      Inflammation, Suppurative                                                  1 [4.0]                                            
   Urinary Bladder                                    (49)         (50)         (48)         (50)                                   
      Calculus Micro Observation Only                               1            1                                                  
      Hemorrhage                                       1 [4.0]                   1 [1.0]                                            
      Inflammation                                                                            1 [3.0]                               
      Transitional Epithelium, Hyperplasia             2 [2.5]                   1 [3.0]      1 [4.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------