Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/13066

TDMS Study 61427-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                VANADIUM PENTOXIDE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
Testes                                 Adenoma                                                                                      
All Organs                             Benign Tumors                                                                                
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                 VANADIUM PENTOXIDE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    11/50 (22%)  6/49 (12%)   6/50 (12%)  |2/49 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/40.13      11/42.79     6/43.26      6/41.64     |2/42.75      2/42.05      1/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        25.7%        13.9%        14.4%       |4.7%         4.8%         2.4%         2.4%         | 
|TERMINAL (d)       |     3/20 (15%)   9/29 (31%)   4/26 (15%)   4/27 (15%)  |2/33 (6%)    0/24 (0%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     652          694          653          533         |731 (T)      652          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400N     P=0.167      P=0.552      P=0.536     |P=0.349N     P=0.612      P=0.545N     P=0.533N     | 
|POLY 3             |     P=0.508N     P=0.054      P=0.417      P=0.392     |P=0.337N     P=0.688      P=0.502N     P=0.502N     | 
|POLY 1.5           |     P=0.528N     P=0.048 *    P=0.389      P=0.379     |P=0.335N     P=0.693N     P=0.499N     P=0.497N     | 
|POLY 6             |     P=0.469N     P=0.071      P=0.464      P=0.420     |P=0.341N     P=0.678      P=0.507N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.500N     P=0.117      P=0.495      P=0.402     |P=0.339N     P=0.685      P=0.545N     P=0.533N     | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.045 *    P=0.357      P=0.370     |P=0.332N     P=0.684N     P=0.492N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Complex                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      2/43.62      0/40.96     |0/42.75      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          633          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.600      (e)          P=0.289      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.593      (e)          P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.592      (e)          P=0.246      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.600      (e)          P=0.278      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.594      (e)          P=0.199      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.594      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/39.93      2/42.62      0/42.93      0/40.96     |0/42.75      1/42.22      0/42.55      1/42.64      | 
|POLY-3 PERCENT (g) |     2.5%         4.7%         0.0%         0.0%        |0.0%         2.4%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     708          716          ---          ---         |---          571          ---          706          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.153N     P=0.633      P=0.428N     P=0.454N    |P=0.402      P=0.500      (e)          P=0.483      | 
|POLY 3             |     P=0.180N     P=0.523      P=0.486N     P=0.495N    |P=0.402      P=0.498      (e)          P=0.499      | 
|POLY 1.5           |     P=0.185N     P=0.510      P=0.494N     P=0.498N    |P=0.405      P=0.501      (e)          P=0.502      | 
|POLY 6             |     P=0.172N     P=0.547      P=0.472N     P=0.487N    |P=0.396      P=0.492      (e)          P=0.496      | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.585      P=0.469N     P=0.482N    |P=0.408      P=0.490      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.189N     P=0.500      P=0.505N     P=0.500N    |P=0.408      P=0.505      (e)          P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   13/50 (26%)  8/49 (16%)   6/50 (12%)  |2/49 (4%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/40.21      13/42.84     8/43.95      6/41.64     |2/42.75      3/42.57      1/42.55      2/42.64      | 
|POLY-3 PERCENT (g) |     12.4%        30.4%        18.2%        14.4%       |4.7%         7.1%         2.4%         4.7%         | 
|TERMINAL (d)       |     3/20 (15%)   10/29 (35%)  4/26 (15%)   4/27 (15%)  |2/33 (6%)    0/24 (0%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     652          694          633          533         |731 (T)      571          731 (T)      706          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.263N     P=0.160      P=0.476      P=0.578N    |P=0.510N     P=0.421      P=0.545N     P=0.660      | 
|POLY 3             |     P=0.357N     P=0.040 *    P=0.334      P=0.525     |P=0.501N     P=0.498      P=0.502N     P=0.693      | 
|POLY 1.5           |     P=0.380N     P=0.034 *    P=0.300      P=0.510     |P=0.497N     P=0.504      P=0.499N     P=0.690N     | 
|POLY 6             |     P=0.317N     P=0.054      P=0.393      P=0.556     |P=0.507N     P=0.488      P=0.507N     P=0.687      | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.098      P=0.333      P=0.539     |P=0.496N     P=0.510      P=0.545N     P=0.679      | 
|COCH-ARM / FISHERS |     P=0.399N     P=0.033 *    P=0.264      P=0.500     |P=0.493N     P=0.510      P=0.492N     P=0.684N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Astrocytoma Malignant                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |0/43.71      2/41.94      2/42.78      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.8%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          667          689          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.511N     P=0.205      P=0.218      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.513N     P=0.228      P=0.232      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.506N     P=0.233      P=0.234      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.221      P=0.230      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.503N     P=0.231      P=0.234      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.247      P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.99      0/42.93      0/40.96     |0/43.71      2/41.94      2/42.78      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         4.8%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          608          ---          ---         |---          667          689          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.574N     P=0.500      (e)          (e)         |P=0.511N     P=0.205      P=0.218      (e)          | 
|POLY 3             |     P=0.552N     P=0.515      (e)          (e)         |P=0.513N     P=0.228      P=0.232      (e)          | 
|POLY 1.5           |     P=0.560N     P=0.507      (e)          (e)         |P=0.506N     P=0.233      P=0.234      (e)          | 
|POLY 6             |     P=0.538N     P=0.531      (e)          (e)         |P=0.523N     P=0.221      P=0.230      (e)          | 
|LOGISTIC REGRESSION|     P=0.563N     P=0.505      (e)          (e)         |P=0.503N     P=0.231      P=0.234      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.500N     P=0.247      P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |2/43.71      0/41.70      3/42.20      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         7.1%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    0/24 (0%)    2/29 (7%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.308N     P=0.311N     P=0.446      P=0.259N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.248N     P=0.484      P=0.243N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.242N     P=0.486      P=0.240N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.256N     P=0.480      P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.308N     (e)          P=0.468      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.247N     P=0.490      P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    2/49 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.91      2/43.12      2/41.21     |0/43.71      1/41.84      2/42.10      3/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         4.6%         4.9%        |0.0%         2.4%         4.8%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          311          680          661         |---          696          725          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266      P=0.240      P=0.313      P=0.283     |P=0.065      P=0.472      P=0.215      P=0.109      | 
|POLY 3             |     P=0.252      P=0.259      P=0.255      P=0.244     |P=0.060      P=0.491      P=0.229      P=0.115      | 
|POLY 1.5           |     P=0.245      P=0.248      P=0.244      P=0.240     |P=0.061      P=0.496      P=0.230      P=0.117      | 
|POLY 6             |     P=0.267      P=0.279      P=0.273      P=0.255     |P=0.059      P=0.484      P=0.226      P=0.113      | 
|LOGISTIC REGRESSION|     P=0.247      P=0.318      P=0.262      P=0.245     |P=0.061      P=0.496      P=0.216      P=0.120      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.242      P=0.247     |P=0.062      P=0.500      P=0.242      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    5/49 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.91      2/43.12      2/41.21     |2/43.71      1/41.84      5/42.22      3/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         4.6%         4.9%        |4.6%         2.4%         11.8%        7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    1/27 (4%)   |2/33 (6%)    0/24 (0%)    3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          311          680          661         |731 (T)      696          698          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266      P=0.240      P=0.313      P=0.283     |P=0.279      P=0.590N     P=0.175      P=0.461      | 
|POLY 3             |     P=0.252      P=0.259      P=0.255      P=0.244     |P=0.280      P=0.515N     P=0.201      P=0.492      | 
|POLY 1.5           |     P=0.245      P=0.248      P=0.244      P=0.240     |P=0.281      P=0.507N     P=0.203      P=0.496      | 
|POLY 6             |     P=0.267      P=0.279      P=0.273      P=0.255     |P=0.278      P=0.527N     P=0.198      P=0.486      | 
|LOGISTIC REGRESSION|     P=0.247      P=0.318      P=0.262      P=0.245     |P=0.273      P=0.537N     P=0.185      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.242      P=0.247     |P=0.282      P=0.500N     P=0.210      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/49 (2%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/39.84      3/42.57      1/42.98      2/40.96     |1/42.75      1/41.70      1/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         7.1%         2.3%         4.9%        |2.3%         2.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   0/26 (0%)    2/27 (7%)   |1/33 (3%)    1/24 (4%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      717          729 (T)     |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605      P=0.445      P=0.685N     P=0.605     |P=0.320N     P=0.689      P=0.733      P=0.519N     | 
|POLY 3             |     P=0.539      P=0.329      P=0.744N     P=0.510     |P=0.312N     P=0.755      P=0.759      P=0.501N     | 
|POLY 1.5           |     P=0.531      P=0.315      P=0.754N     P=0.503     |P=0.311N     P=0.760      P=0.759      P=0.498N     | 
|POLY 6             |     P=0.557      P=0.355      P=0.727N     P=0.525     |P=0.315N     P=0.747      P=0.756      P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.597      P=0.445      P=0.695N     P=0.605     |P=0.320N     P=0.689      P=0.733      (e)          | 
|COCH-ARM / FISHERS |     P=0.525      P=0.309      P=0.747      P=0.500     |P=0.309N     P=0.747N     P=0.753N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    3/49 (6%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/39.84      4/42.63      3/42.96      0/40.96     |1/42.75      0/41.70      0/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         9.4%         7.0%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   2/26 (8%)    0/27 (0%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      714          722          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168N     P=0.312      P=0.414      P=0.440N    |P=0.313N     P=0.564N     P=0.526N     P=0.519N     | 
|POLY 3             |     P=0.218N     P=0.199      P=0.332      P=0.494N    |P=0.298N     P=0.505N     P=0.502N     P=0.501N     | 
|POLY 1.5           |     P=0.227N     P=0.187      P=0.316      P=0.498N    |P=0.301N     P=0.500N     P=0.501N     P=0.498N     | 
|POLY 6             |     P=0.199N     P=0.223      P=0.359      P=0.486N    |P=0.293N     P=0.512N     P=0.504N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.174N     P=0.293      P=0.432      (e)         |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.233N     P=0.181      P=0.301      P=0.500N    |P=0.304N     P=0.495N     P=0.500N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   4/49 (8%)    2/50 (4%)   |2/49 (4%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/39.84      7/42.63      4/43.00      2/40.96     |2/42.75      1/41.70      1/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         16.4%        9.3%         4.9%        |4.7%         2.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     2/20 (10%)   6/29 (21%)   2/26 (8%)    2/27 (7%)   |2/33 (6%)    1/24 (4%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      714          717          729 (T)     |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.236N     P=0.200      P=0.484      P=0.584N    |P=0.162N     P=0.611N     P=0.545N     P=0.259N     | 
|POLY 3             |     P=0.319N     P=0.094      P=0.372      P=0.685N    |P=0.152N     P=0.509N     P=0.503N     P=0.238N     | 
|POLY 1.5           |     P=0.333N     P=0.085      P=0.351      P=0.691N    |P=0.152N     P=0.500N     P=0.502N     P=0.235N     | 
|POLY 6             |     P=0.291N     P=0.113      P=0.408      P=0.670N    |P=0.152N     P=0.522N     P=0.508N     P=0.242N     | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.189      P=0.497      P=0.584N    |P=0.162N     P=0.611N     P=0.545N     (e)          | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.080      P=0.329      P=0.691N    |P=0.151N     P=0.492N     P=0.500N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   5/48 (10%)   6/50 (12%)  |0/49 (0%)    3/49 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/39.84      8/42.69      5/42.92      6/42.22     |0/43.46      3/41.03      1/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        18.7%        11.7%        14.2%       |0.0%         7.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     4/20 (20%)   7/29 (24%)   3/26 (12%)   3/27 (11%)  |0/33 (0%)    2/24 (8%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      608          694          558         |---          675          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.555N     P=0.375      P=0.606N     P=0.507     |P=0.375N     P=0.085      P=0.474      (e)          | 
|POLY 3             |     P=0.500      P=0.209      P=0.547      P=0.405     |P=0.381N     P=0.108      P=0.496      (e)          | 
|POLY 1.5           |     P=0.478      P=0.186      P=0.515      P=0.386     |P=0.371N     P=0.113      P=0.499      (e)          | 
|POLY 6             |     P=0.541      P=0.255      P=0.596      P=0.446     |P=0.395N     P=0.102      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.475      P=0.315      P=0.584N     P=0.385     |P=0.372N     P=0.105      P=0.474      (e)          | 
|COCH-ARM / FISHERS |     P=0.457      P=0.168      P=0.474      P=0.370     |P=0.360N     P=0.121      P=0.505      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/49 (6%)    1/48 (2%)    3/50 (6%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      3/42.56      1/42.77      3/40.96     |0/43.46      0/40.82      0/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         7.1%         2.3%         7.3%        |0.0%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    2/29 (7%)    1/26 (4%)    3/27 (11%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          652          729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202      P=0.185      P=0.552      P=0.177     |P=0.204      (e)          (e)          P=0.481      | 
|POLY 3             |     P=0.177      P=0.130      P=0.514      P=0.123     |P=0.199      (e)          (e)          P=0.496      | 
|POLY 1.5           |     P=0.171      P=0.122      P=0.504      P=0.120     |P=0.200      (e)          (e)          P=0.500      | 
|POLY 6             |     P=0.190      P=0.147      P=0.529      P=0.130     |P=0.198      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.176      P=0.135      P=0.552      P=0.177     |(e)          (e)          (e)          P=0.481      | 
|COCH-ARM / FISHERS |     P=0.167      P=0.117      P=0.490      P=0.121     |P=0.201      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/49 (20%)  6/48 (13%)   9/50 (18%)  |0/49 (0%)    3/49 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/39.84      10/42.98     6/42.92      9/42.22     |0/43.46      3/41.03      1/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        23.3%        14.0%        21.3%       |0.0%         7.3%         2.4%         2.4%         | 
|TERMINAL (d)       |     4/20 (20%)   8/29 (28%)   4/26 (15%)   6/27 (22%)  |0/33 (0%)    2/24 (8%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      608          694          558         |---          675          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.208      P=0.550      P=0.224     |P=0.582      P=0.085      P=0.474      P=0.481      | 
|POLY 3             |     P=0.232      P=0.092      P=0.416      P=0.134     |P=0.575      P=0.108      P=0.496      P=0.496      | 
|POLY 1.5           |     P=0.215      P=0.078      P=0.384      P=0.123     |P=0.586      P=0.113      P=0.499      P=0.500      | 
|POLY 6             |     P=0.265      P=0.124      P=0.468      P=0.160     |P=0.560      P=0.102      P=0.492      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.212      P=0.140      P=0.584      P=0.134     |P=0.583      P=0.105      P=0.474      P=0.481      | 
|COCH-ARM / FISHERS |     P=0.201      P=0.068      P=0.344      P=0.117     |P=0.598      P=0.121      P=0.505      P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.57      0/43.82      0/40.96     |2/44.68      2/41.91      2/42.62      3/42.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |4.5%         4.8%         4.7%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |1/33 (3%)    1/24 (4%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |234          675          712          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.574      (e)          (e)         |P=0.382      P=0.630      P=0.654      P=0.472      | 
|POLY 3             |     P=0.553N     P=0.513      (e)          (e)         |P=0.374      P=0.671      P=0.677      P=0.480      | 
|POLY 1.5           |     P=0.560N     P=0.506      (e)          (e)         |P=0.379      P=0.680      P=0.682      P=0.487      | 
|POLY 6             |     P=0.539N     P=0.527      (e)          (e)         |P=0.370      P=0.658      P=0.671      P=0.472      | 
|LOGISTIC REGRESSION|     (e)          P=0.574      (e)          (e)         |P=0.388      P=0.697      P=0.670N     P=0.500      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.387      P=0.691N     P=0.691N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.57      0/43.82      0/40.96     |3/44.68      2/41.91      2/42.62      3/42.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |6.7%         4.8%         4.7%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    1/24 (4%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |234          675          712          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.574      (e)          (e)         |P=0.534      P=0.590N     P=0.550N     P=0.630      | 
|POLY 3             |     P=0.553N     P=0.513      (e)          (e)         |P=0.533      P=0.529N     P=0.521N     P=0.642      | 
|POLY 1.5           |     P=0.560N     P=0.506      (e)          (e)         |P=0.536      P=0.517N     P=0.516N     P=0.649      | 
|POLY 6             |     P=0.539N     P=0.527      (e)          (e)         |P=0.529      P=0.545N     P=0.529N     P=0.635      | 
|LOGISTIC REGRESSION|     (e)          P=0.574      (e)          (e)         |P=0.546      P=0.494N     P=0.476N     P=0.662N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.544      P=0.500N     P=0.500N     P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |16/50 (32%)  13/50 (26%)  20/50 (40%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |16/44.85     13/43.11     20/44.11     21/43.44     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |35.7%        30.2%        45.3%        48.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |13/33 (39%)  7/24 (29%)   13/29 (45%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |458          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.083      P=0.528      P=0.161      P=0.113      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.065      P=0.372N     P=0.235      P=0.156      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.073      P=0.352N     P=0.243      P=0.176      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.056      P=0.399N     P=0.231      P=0.135      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.072      P=0.374N     P=0.233      P=0.158      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.088      P=0.330N     P=0.266      P=0.204      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |17/50 (34%)  13/50 (26%)  20/50 (40%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |17/44.85     13/43.11     20/44.11     21/43.44     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |37.9%        30.2%        45.3%        48.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |14/33 (42%)  7/24 (29%)   13/29 (45%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |458          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.112      P=0.570N     P=0.211      P=0.157      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.092      P=0.293N     P=0.308      P=0.215      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.103      P=0.275N     P=0.315      P=0.238      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.082      P=0.316N     P=0.304      P=0.190      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.100      P=0.298N     P=0.301      P=0.214      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.120      P=0.257N     P=0.339      P=0.268      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |19/50 (38%)  14/50 (28%)  22/50 (44%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |19/45.82     14/43.32     22/44.18     22/43.68     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |41.5%        32.3%        49.8%        50.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |15/33 (46%)  7/24 (29%)   14/29 (48%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |234          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.150      P=0.501N     P=0.209      P=0.220      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.112      P=0.248N     P=0.278      P=0.260      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.126      P=0.229N     P=0.291      P=0.288      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.101      P=0.267N     P=0.273      P=0.235      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.141      P=0.207N     P=0.320      P=0.317      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.157      P=0.198N     P=0.342      P=0.342      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      1/41.46     |0/43.71      2/42.37      1/42.74      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         2.4%        |0.0%         4.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          578         |---          571          680          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.542      P=0.278      (e)          P=0.482     |P=0.471N     P=0.228      P=0.500      (e)          | 
|POLY 3             |     P=0.560      P=0.255      (e)          P=0.508     |P=0.472N     P=0.230      P=0.496      (e)          | 
|POLY 1.5           |     P=0.548      P=0.245      (e)          P=0.503     |P=0.466N     P=0.234      P=0.497      (e)          | 
|POLY 6             |     P=0.582      P=0.273      (e)          P=0.518     |P=0.481N     P=0.224      P=0.493      (e)          | 
|LOGISTIC REGRESSION|     P=0.541      P=0.234      (e)          P=0.519     |P=0.459N     P=0.239      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      2/41.67     |0/43.71      3/42.37      2/43.42      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         4.8%        |0.0%         7.1%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          578         |---          571          499          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.255      P=0.278      (e)          P=0.254     |P=0.420N     P=0.100      P=0.240      (e)          | 
|POLY 3             |     P=0.263      P=0.255      (e)          P=0.247     |P=0.423N     P=0.113      P=0.236      (e)          | 
|POLY 1.5           |     P=0.254      P=0.245      (e)          P=0.241     |P=0.416N     P=0.116      P=0.236      (e)          | 
|POLY 6             |     P=0.280      P=0.273      (e)          P=0.259     |P=0.434N     P=0.108      P=0.234      (e)          | 
|LOGISTIC REGRESSION|     P=0.251      P=0.234      (e)          P=0.241     |P=0.406N     P=0.123      P=0.255      (e)          | 
|COCH-ARM / FISHERS |     P=0.247      P=0.247      (e)          P=0.247     |P=0.409N     P=0.121      P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      0/40.96     |0/43.71      1/42.22      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          ---         |---          571          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.393N     P=0.278      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.383N     P=0.255      (e)          (e)         |P=0.574N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.395N     P=0.245      (e)          (e)         |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.362N     P=0.273      (e)          (e)         |P=0.579N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.406N     P=0.234      (e)          (e)         |P=0.570N     P=0.488      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  35/50 (70%)  39/50 (78%)  32/50 (64%) |31/49 (63%)  29/50 (58%)  24/49 (49%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     35/45.87     35/45.18     39/48.10     32/45.64    |31/45.50     29/45.48     24/43.58     30/45.10     | 
|POLY-3 PERCENT (g) |     76.3%        77.5%        81.1%        70.1%       |68.1%        63.8%        55.1%        66.5%        | 
|TERMINAL (d)       |     14/20 (70%)  24/29 (83%)  20/26 (77%)  19/27 (70%) |24/33 (73%)  15/24 (63%)  18/29 (62%)  19/30 (63%)  | 
|FIRST INCIDENCE    |     477          485          519          332         |458          408          617          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.069N     P=0.268N     P=0.105N    |P=0.497N     P=0.236      P=0.281N     P=0.461      | 
|POLY 3             |     P=0.263N     P=0.550      P=0.371      P=0.324N    |P=0.469N     P=0.411N     P=0.140N     P=0.525N     | 
|POLY 1.5           |     P=0.279N     P=0.553      P=0.310      P=0.330N    |P=0.445N     P=0.383N     P=0.126N     P=0.491N     | 
|POLY 6             |     P=0.238N     P=0.560      P=0.470      P=0.311N    |P=0.489N     P=0.455N     P=0.166N     P=0.555N     | 
|LOGISTIC REGRESSION|     P=0.297N     P=0.492N     P=0.352      P=0.322N    |P=0.426N     P=0.412N     P=0.108N     P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.309N     P=0.586N     P=0.247      P=0.335N    |P=0.409N     P=0.371N     P=0.111N     P=0.449N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      1/43.82      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    1/26 (4%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.417N     P=0.327      P=0.552      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.444N     P=0.252      P=0.519      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.454N     P=0.244      P=0.510      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.425N     P=0.270      P=0.533      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.430N     P=0.291      P=0.552      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      1/43.82      1/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.3%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    1/26 (4%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.327      P=0.552      P=0.560     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.514      P=0.252      P=0.519      P=0.506     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.505      P=0.244      P=0.510      P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.534      P=0.270      P=0.533      P=0.514     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.539      P=0.291      P=0.552      P=0.560     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.247      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      2/43.82      2/41.21     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         4.6%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      661         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.284      P=0.327      P=0.297      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.254      P=0.252      P=0.259      P=0.244     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247      P=0.244      P=0.249      P=0.240     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.270      P=0.270      P=0.276      P=0.255     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.253      P=0.291      P=0.297      P=0.245     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.247      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   4/50 (8%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      8/42.87      4/44.35      4/41.85     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        18.7%        9.0%         9.6%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200N     P=0.535      P=0.342N     P=0.375N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.254N     P=0.315      P=0.440N     P=0.476N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.267N     P=0.292      P=0.468N     P=0.490N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.230N     P=0.361      P=0.396N     P=0.446N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.264N     P=0.414      P=0.427N     P=0.488N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.277      P=0.500N     P=0.500N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/40.22      0/42.57      4/43.85      2/40.96     |1/43.95      0/41.70      1/42.63      1/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         9.1%         4.9%        |2.3%         0.0%         2.4%         2.4%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    3/26 (12%)   2/27 (7%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     624          ---          722          729 (T)     |666          ---          710          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.192N     P=0.465      P=0.609N    |P=0.527      P=0.510N     P=0.742      P=0.741      | 
|POLY 3             |     P=0.396      P=0.224N     P=0.377      P=0.688N    |P=0.537      P=0.510N     P=0.754      P=0.754      | 
|POLY 1.5           |     P=0.399      P=0.232N     P=0.359      P=0.692N    |P=0.538      P=0.505N     P=0.756      P=0.757      | 
|POLY 6             |     P=0.396      P=0.211N     P=0.408      P=0.676N    |P=0.536      P=0.519N     P=0.750      P=0.748      | 
|LOGISTIC REGRESSION|     P=0.428      P=0.236N     P=0.428      P=0.673N    |P=0.536      P=0.497N     P=0.762      P=0.760      | 
|COCH-ARM / FISHERS |     P=0.404      P=0.247N     P=0.339      P=0.691N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/41.38      1/42.65      5/44.13      3/41.81     |1/43.95      1/41.76      1/42.63      1/42.54      | 
|POLY-3 PERCENT (g) |     14.5%        2.3%         11.3%        7.2%        |2.3%         2.4%         2.4%         2.4%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    3/26 (12%)   2/27 (7%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     612          708          655          390         |666          717          710          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285N     P=0.035N*    P=0.338N     P=0.194N    |P=0.617      P=0.727      P=0.742      P=0.741      | 
|POLY 3             |     P=0.341N     P=0.050N     P=0.455N     P=0.235N    |P=0.626      P=0.749      P=0.754      P=0.754      | 
|POLY 1.5           |     P=0.340N     P=0.054N     P=0.475N     P=0.239N    |P=0.629      P=0.755      P=0.756      P=0.757      | 
|POLY 6             |     P=0.345N     P=0.043N*    P=0.424N     P=0.226N    |P=0.620      P=0.740      P=0.750      P=0.748      | 
|LOGISTIC REGRESSION|     P=0.343N     P=0.060N     P=0.489N     P=0.241N    |P=0.629      P=0.760      P=0.762      P=0.760      | 
|COCH-ARM / FISHERS |     P=0.341N     P=0.056N     P=0.500N     P=0.243N    |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/41.00      1/42.65      1/44.10      1/41.81     |0/43.71      1/41.76      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     9.8%         2.3%         2.3%         2.4%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     612          708          655          390         |---          717          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.127N     P=0.124N     P=0.173N    |P=0.575N     P=0.450      (e)          (e)          | 
|POLY 3             |     P=0.133N     P=0.166N     P=0.157N     P=0.171N    |P=0.575N     P=0.491      (e)          (e)          | 
|POLY 1.5           |     P=0.133N     P=0.174N     P=0.167N     P=0.176N    |P=0.571N     P=0.496      (e)          (e)          | 
|POLY 6             |     P=0.134N     P=0.151N     P=0.142N     P=0.164N    |P=0.580N     P=0.484      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.134N     P=0.183N     P=0.209N     P=0.158N    |P=0.571N     P=0.482      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.181N     P=0.181N     P=0.181N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/40.31      0/42.57      0/43.82      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     638          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103N     P=0.191N     P=0.184N     P=0.221N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.116N     P=0.225N     P=0.219N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.114N     P=0.232N     P=0.227N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.120N     P=0.212N     P=0.206N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.116N     P=0.239N     P=0.247N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/40.08      6/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        14.0%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   5/29 (17%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.107N     P=0.601      P=0.233N     P=0.248N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.136N     P=0.410      P=0.291N     P=0.319N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.144N     P=0.387      P=0.312N     P=0.330N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.123N     P=0.456      P=0.258N     P=0.297N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.144N     P=0.522      P=0.298N     P=0.328N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.151N     P=0.370      P=0.339N     P=0.339N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/39.95      0/42.57      3/44.10      1/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         6.8%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     701          ---          655          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.503N     P=0.169N     P=0.622      P=0.414N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.561N     P=0.223N     P=0.545      P=0.491N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.558N     P=0.231N     P=0.524      P=0.497N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.563N     P=0.208N     P=0.578      P=0.478N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.538N     P=0.188N     P=0.583      P=0.439N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.247N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      7/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        16.4%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051N     P=0.611N     P=0.131N     P=0.146N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.068N     P=0.421      P=0.178N     P=0.201N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.073N     P=0.397      P=0.195N     P=0.210N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.060N     P=0.469      P=0.152N     P=0.184N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.529      P=0.188N     P=0.210N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.079N     P=0.380      P=0.218N     P=0.218N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      7/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        16.4%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051N     P=0.611N     P=0.131N     P=0.146N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.068N     P=0.421      P=0.178N     P=0.201N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.073N     P=0.397      P=0.195N     P=0.210N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.060N     P=0.469      P=0.152N     P=0.184N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.529      P=0.188N     P=0.210N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.079N     P=0.380      P=0.218N     P=0.218N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  32/50 (64%)  34/50 (68%)  34/50 (68%) |                                                    | 
|POLY-3 RATE (b)    |     36/45.75     32/45.25     34/45.67     34/43.31    |                                                    | 
|POLY-3 PERCENT (g) |     78.7%        70.7%        74.5%        78.5%       |                                                    | 
|TERMINAL (d)       |     18/20 (90%)  21/29 (72%)  23/26 (89%)  25/27 (93%) |                                                    | 
|FIRST INCIDENCE    |     502          571          584          533         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.148N     P=0.017N*    P=0.046N*    P=0.060N    |                                                    | 
|POLY 3             |     P=0.460      P=0.252N     P=0.402N     P=0.604N    |                                                    | 
|POLY 1.5           |     P=0.536      P=0.268N     P=0.406N     P=0.519N    |                                                    | 
|POLY 6             |     P=0.349      P=0.202N     P=0.397N     P=0.538     |                                                    | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.174N     P=0.182N     P=0.362N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.459N     P=0.260N     P=0.414N     P=0.414N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    4/49 (8%)    2/50 (4%)   |2/50 (4%)    4/50 (8%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/40.17      4/42.85      4/43.04      2/41.13     |2/44.04      4/41.76      4/42.84      3/42.56      | 
|POLY-3 PERCENT (g) |     2.5%         9.3%         9.3%         4.9%        |4.5%         9.6%         9.3%         7.1%         | 
|TERMINAL (d)       |     0/20 (0%)    3/29 (10%)   2/26 (8%)    1/27 (4%)   |1/33 (3%)    3/24 (13%)   3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     638          652          712          684         |638          717          652          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566N     P=0.281      P=0.291      P=0.565     |P=0.470      P=0.224      P=0.301      P=0.462      | 
|POLY 3             |     P=0.532      P=0.198      P=0.199      P=0.508     |P=0.462      P=0.312      P=0.324      P=0.484      | 
|POLY 1.5           |     P=0.524      P=0.187      P=0.187      P=0.503     |P=0.472      P=0.325      P=0.329      P=0.492      | 
|POLY 6             |     P=0.554      P=0.221      P=0.221      P=0.522     |P=0.448      P=0.293      P=0.316      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.538      P=0.196      P=0.216      P=0.505     |P=0.466      P=0.303      P=0.328      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.520      P=0.181      P=0.175      P=0.500     |P=0.481      P=0.339      P=0.339      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    5/49 (10%)   3/50 (6%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/40.17      4/42.85      5/43.61      3/41.13     |3/44.42      5/41.76      4/42.84      3/42.56      | 
|POLY-3 PERCENT (g) |     2.5%         9.3%         11.5%        7.3%        |6.8%         12.0%        9.3%         7.1%         | 
|TERMINAL (d)       |     0/20 (0%)    3/29 (10%)   2/26 (8%)    2/27 (7%)   |1/33 (3%)    4/24 (17%)   3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     638          652          551          684         |625          717          652          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.408      P=0.281      P=0.180      P=0.387     |P=0.495N     P=0.231      P=0.457      P=0.622      | 
|POLY 3             |     P=0.340      P=0.198      P=0.120      P=0.313     |P=0.504N     P=0.322      P=0.480      P=0.643      | 
|POLY 1.5           |     P=0.333      P=0.187      P=0.109      P=0.308     |P=0.493N     P=0.340      P=0.488      P=0.653      | 
|POLY 6             |     P=0.359      P=0.221      P=0.140      P=0.327     |P=0.521N     P=0.296      P=0.468      P=0.628      | 
|LOGISTIC REGRESSION|     P=0.336      P=0.196      P=0.096      P=0.318     |P=0.494N     P=0.333      P=0.496      P=0.659      | 
|COCH-ARM / FISHERS |     P=0.331      P=0.181      P=0.098      P=0.309     |P=0.482N     P=0.357      P=0.500      P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      1/42.93      0/40.96     |2/43.74      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    0/27 (0%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |722          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.722      (e)          P=0.552      (e)         |P=0.124N     P=0.311N     P=0.268N     P=0.261N     | 
|POLY 3             |     P=0.693      (e)          P=0.515      (e)         |P=0.110N     P=0.248N     P=0.243N     P=0.243N     | 
|POLY 1.5           |     P=0.691      (e)          P=0.506      (e)         |P=0.112N     P=0.242N     P=0.241N     P=0.240N     | 
|POLY 6             |     P=0.699      (e)          P=0.529      (e)         |P=0.107N     P=0.257N     P=0.247N     P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.552      (e)         |P=0.121N     P=0.274N     P=0.255N     P=0.254N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.495      (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/43.82      1/41.46     |0/43.71      2/41.84      1/42.74      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |0.0%         4.8%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          578         |---          695          680          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189      (e)          (e)          P=0.482     |P=0.473N     P=0.194      P=0.500      (e)          | 
|POLY 3             |     P=0.201      (e)          (e)          P=0.508     |P=0.473N     P=0.227      P=0.496      (e)          | 
|POLY 1.5           |     P=0.200      (e)          (e)          P=0.503     |P=0.467N     P=0.232      P=0.497      (e)          | 
|POLY 6             |     P=0.203      (e)          (e)          P=0.518     |P=0.482N     P=0.220      P=0.493      (e)          | 
|LOGISTIC REGRESSION|     P=0.207      (e)          (e)          P=0.519     |P=0.464N     P=0.221      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   3/50 (6%)    7/50 (14%)   13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |6/44.18      3/41.90      7/44.02      13/43.28     | 
|POLY-3 PERCENT (g) |                                                        |13.6%        7.2%         15.9%        30.0%        | 
|TERMINAL (d)       |                                                        |4/33 (12%)   1/24 (4%)    5/29 (17%)   8/30 (27%)   | 
|FIRST INCIDENCE    |                                                        |624          694          433          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.011 *    P=0.379N     P=0.419      P=0.047 *    | 
|POLY 3             |                                                        |P=0.008 **   P=0.268N     P=0.497      P=0.051      | 
|POLY 1.5           |                                                        |P=0.008 **   P=0.255N     P=0.499      P=0.056      | 
|POLY 6             |                                                        |P=0.008 **   P=0.289N     P=0.487      P=0.046 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.009 **   P=0.272N     P=0.502      P=0.050      | 
|COCH-ARM / FISHERS |                                                        |P=0.010 *    P=0.243N     P=0.500      P=0.062      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   3/50 (6%)    7/50 (14%)   14/50 (28%)  | 
|POLY-3 RATE (b)    |                                                        |6/44.18      3/41.90      7/44.02      14/43.80     | 
|POLY-3 PERCENT (g) |                                                        |13.6%        7.2%         15.9%        32.0%        | 
|TERMINAL (d)       |                                                        |4/33 (12%)   1/24 (4%)    5/29 (17%)   8/30 (27%)   | 
|FIRST INCIDENCE    |                                                        |624          694          433          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.006 **   P=0.379N     P=0.419      P=0.031 *    | 
|POLY 3             |                                                        |P=0.004 **   P=0.268N     P=0.497      P=0.033 *    | 
|POLY 1.5           |                                                        |P=0.004 **   P=0.255N     P=0.499      P=0.035 *    | 
|POLY 6             |                                                        |P=0.004 **   P=0.289N     P=0.487      P=0.030 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.004 **   P=0.272N     P=0.502      P=0.034 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.005 **   P=0.243N     P=0.500      P=0.039 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  21/50 (42%)  19/50 (38%)  17/50 (34%) |21/50 (42%)  23/50 (46%)  22/50 (44%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     22/46.05     21/44.98     19/46.40     17/43.33    |21/46.50     23/45.82     22/46.05     15/44.82     | 
|POLY-3 PERCENT (g) |     47.8%        46.7%        41.0%        39.2%       |45.2%        50.2%        47.8%        33.5%        | 
|TERMINAL (d)       |     4/20 (20%)   13/29 (45%)  6/26 (23%)   9/27 (33%)  |11/33 (33%)  8/24 (33%)   10/29 (35%)  8/30 (27%)   | 
|FIRST INCIDENCE    |     502          493          528          552         |519          366          421          514          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.105N     P=0.207N     P=0.146N     P=0.128N    |P=0.159N     P=0.183      P=0.372      P=0.263N     | 
|POLY 3             |     P=0.205N     P=0.543N     P=0.324N     P=0.271N    |P=0.108N     P=0.391      P=0.483      P=0.175N     | 
|POLY 1.5           |     P=0.185N     P=0.533N     P=0.332N     P=0.245N    |P=0.098N     P=0.414      P=0.492      P=0.159N     | 
|POLY 6             |     P=0.228N     P=0.542N     P=0.312N     P=0.301N    |P=0.129N     P=0.348      P=0.457      P=0.204N     | 
|LOGISTIC REGRESSION|     P=0.157N     P=0.509N     P=0.431N     P=0.208N    |P=0.090N     P=0.420      P=0.496      P=0.151N     | 
|COCH-ARM / FISHERS |     P=0.158N     P=0.500N     P=0.342N     P=0.206N    |P=0.090N     P=0.420      P=0.500      P=0.149N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.13      0/42.57      3/43.89      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         6.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     650          ---          712          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.463N     P=0.421      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.505N     P=0.488N     P=0.338      P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.503N     P=0.495N     P=0.323      P=0.499N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.504N     P=0.475N     P=0.362      P=0.489N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.503N     P=0.357      P=0.500N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.13      0/42.57      3/43.89      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         6.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     650          ---          712          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.463N     P=0.421      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.505N     P=0.488N     P=0.338      P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.503N     P=0.495N     P=0.323      P=0.499N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.504N     P=0.475N     P=0.362      P=0.489N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.503N     P=0.357      P=0.500N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  47/50 (94%)  49/50 (98%)  46/50 (92%) |41/50 (82%)  39/50 (78%)  41/50 (82%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     48/48.66     47/47.50     49/49.16     46/48.35    |41/47.98     39/47.44     41/47.44     39/45.97     | 
|POLY-3 PERCENT (g) |     98.6%        99.0%        99.7%        95.1%       |85.5%        82.2%        86.4%        84.8%        | 
|TERMINAL (d)       |     20/20 (100%) 29/29 (100%) 26/26 (100%) 26/27 (96%) |29/33 (88%)  19/24 (79%)  25/29 (86%)  25/30 (83%)  | 
|FIRST INCIDENCE    |     477          485          519          332         |458          408          433          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.024N*    P=0.083N     P=0.087N    |P=0.504N     P=0.164      P=0.295      P=0.472      | 
|POLY 3             |     P=0.104N     P=0.905      P=0.805      P=0.315N    |P=0.522      P=0.437N     P=0.565      P=0.585N     | 
|POLY 1.5           |     P=0.155N     P=0.796N     P=0.628      P=0.314N    |P=0.515N     P=0.409N     P=0.570      P=0.504N     | 
|POLY 6             |     P=0.085N     P=0.997      P=0.995      P=0.332N    |P=0.463      P=0.471N     P=0.559      P=0.593      | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.757N     P=0.659      P=0.382N    |P=0.421N     P=0.432N     P=0.561      P=0.440N     | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.500N     P=0.500      P=0.339N    |P=0.406N     P=0.402N     P=0.602N     P=0.402N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  31/50 (62%)  30/50 (60%)  24/50 (48%) |28/50 (56%)  29/50 (58%)  27/50 (54%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     28/48.04     31/47.82     30/47.78     24/45.03    |28/47.92     29/46.72     27/47.10     22/46.91     | 
|POLY-3 PERCENT (g) |     58.3%        64.8%        62.8%        53.3%       |58.4%        62.1%        57.3%        46.9%        | 
|TERMINAL (d)       |     5/20 (25%)   16/29 (55%)  13/26 (50%)  12/27 (44%) |14/33 (42%)  11/24 (46%)  12/29 (41%)  11/30 (37%)  | 
|FIRST INCIDENCE    |     373          311          528          390         |234          366          421          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.118N     P=0.351N     P=0.315N     P=0.165N    |P=0.195N     P=0.191      P=0.469      P=0.315N     | 
|POLY 3             |     P=0.284N     P=0.325      P=0.404      P=0.390N    |P=0.104N     P=0.439      P=0.540N     P=0.177N     | 
|POLY 1.5           |     P=0.238N     P=0.331      P=0.406      P=0.344N    |P=0.100N     P=0.467      P=0.531N     P=0.166N     | 
|POLY 6             |     P=0.338N     P=0.327      P=0.410      P=0.442N    |P=0.117N     P=0.395      P=0.563N     P=0.201N     | 
|LOGISTIC REGRESSION|     P=0.176N     P=0.237      P=0.271      P=0.286N    |P=0.095N     P=0.514      P=0.490N     P=0.146N     | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.342      P=0.420      P=0.274N    |P=0.098N     P=0.500      P=0.500N     P=0.159N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 49/50 (98%)  49/50 (98%) |47/50 (94%)  47/50 (94%)  46/50 (92%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     49/49.16     49/49.40    |47/50.00     47/49.48     46/49.01     45/48.46     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       99.7%        99.2%       |94.0%        95.0%        93.9%        92.9%        | 
|TERMINAL (d)       |     20/20 (100%) 29/29 (100%) 26/26 (100%) 27/27 (100%)|30/33 (91%)  22/24 (92%)  26/29 (90%)  27/30 (90%)  | 
|FIRST INCIDENCE    |     373          311          519          332         |234          366          421          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146N     (e)          P=0.051N     P=0.113N    |P=0.459N     P=0.083      P=0.347      P=0.456      | 
|POLY 3             |     P=0.530N     (e)          P=1.000N     P=0.930N    |P=0.448N     P=0.589      P=0.651N     P=0.572N     | 
|POLY 1.5           |     P=0.316N     (e)          P=0.936N     P=0.716N    |P=0.378N     P=0.621      P=0.640N     P=0.495N     | 
|POLY 6             |     P=0.995N     (e)          P=1.000N     P=1.000N    |P=0.496N     P=0.548      P=0.652N     P=0.627N     | 
|LOGISTIC REGRESSION|     P=0.252N     (e)          P=0.398N     P=0.538N    |P=0.249N     P=0.645N     P=0.519N     P=0.360N     | 
|COCH-ARM / FISHERS |     P=0.236N     (e)          P=0.500N     P=0.500N    |P=0.248N     P=0.661N     P=0.500N     P=0.357N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).