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TDMS Study 61427-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:09:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                VANADIUM PENTOXIDE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
Testes                                 Adenoma                                                                                      
All Organs                             Benign Tumors                                                                                
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                 VANADIUM PENTOXIDE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    11/50 (22%)  6/49 (12%)   6/50 (12%)  |2/49 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/40.13      11/42.79     6/43.26      6/41.64     |2/42.75      2/42.05      1/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        25.7%        13.9%        14.4%       |4.7%         4.8%         2.4%         2.4%         | 
|TERMINAL (d)       |     3/20 (15%)   9/29 (31%)   4/26 (15%)   4/27 (15%)  |2/33 (6%)    0/24 (0%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     652          694          653          533         |731 (T)      652          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400N     P=0.167      P=0.552      P=0.536     |P=0.349N     P=0.612      P=0.545N     P=0.533N     | 
|POLY 3             |     P=0.508N     P=0.054      P=0.417      P=0.392     |P=0.337N     P=0.688      P=0.502N     P=0.502N     | 
|POLY 1.5           |     P=0.528N     P=0.048 *    P=0.389      P=0.379     |P=0.335N     P=0.693N     P=0.499N     P=0.497N     | 
|POLY 6             |     P=0.469N     P=0.071      P=0.464      P=0.420     |P=0.341N     P=0.678      P=0.507N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.500N     P=0.117      P=0.495      P=0.402     |P=0.339N     P=0.685      P=0.545N     P=0.533N     | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.045 *    P=0.357      P=0.370     |P=0.332N     P=0.684N     P=0.492N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Complex                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      2/43.62      0/40.96     |0/42.75      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          633          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.600      (e)          P=0.289      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.593      (e)          P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.592      (e)          P=0.246      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.600      (e)          P=0.278      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.594      (e)          P=0.199      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.594      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/39.93      2/42.62      0/42.93      0/40.96     |0/42.75      1/42.22      0/42.55      1/42.64      | 
|POLY-3 PERCENT (g) |     2.5%         4.7%         0.0%         0.0%        |0.0%         2.4%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     708          716          ---          ---         |---          571          ---          706          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.153N     P=0.633      P=0.428N     P=0.454N    |P=0.402      P=0.500      (e)          P=0.483      | 
|POLY 3             |     P=0.180N     P=0.523      P=0.486N     P=0.495N    |P=0.402      P=0.498      (e)          P=0.499      | 
|POLY 1.5           |     P=0.185N     P=0.510      P=0.494N     P=0.498N    |P=0.405      P=0.501      (e)          P=0.502      | 
|POLY 6             |     P=0.172N     P=0.547      P=0.472N     P=0.487N    |P=0.396      P=0.492      (e)          P=0.496      | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.585      P=0.469N     P=0.482N    |P=0.408      P=0.490      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.189N     P=0.500      P=0.505N     P=0.500N    |P=0.408      P=0.505      (e)          P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   13/50 (26%)  8/49 (16%)   6/50 (12%)  |2/49 (4%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/40.21      13/42.84     8/43.95      6/41.64     |2/42.75      3/42.57      1/42.55      2/42.64      | 
|POLY-3 PERCENT (g) |     12.4%        30.4%        18.2%        14.4%       |4.7%         7.1%         2.4%         4.7%         | 
|TERMINAL (d)       |     3/20 (15%)   10/29 (35%)  4/26 (15%)   4/27 (15%)  |2/33 (6%)    0/24 (0%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     652          694          633          533         |731 (T)      571          731 (T)      706          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.263N     P=0.160      P=0.476      P=0.578N    |P=0.510N     P=0.421      P=0.545N     P=0.660      | 
|POLY 3             |     P=0.357N     P=0.040 *    P=0.334      P=0.525     |P=0.501N     P=0.498      P=0.502N     P=0.693      | 
|POLY 1.5           |     P=0.380N     P=0.034 *    P=0.300      P=0.510     |P=0.497N     P=0.504      P=0.499N     P=0.690N     | 
|POLY 6             |     P=0.317N     P=0.054      P=0.393      P=0.556     |P=0.507N     P=0.488      P=0.507N     P=0.687      | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.098      P=0.333      P=0.539     |P=0.496N     P=0.510      P=0.545N     P=0.679      | 
|COCH-ARM / FISHERS |     P=0.399N     P=0.033 *    P=0.264      P=0.500     |P=0.493N     P=0.510      P=0.492N     P=0.684N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Astrocytoma Malignant                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |0/43.71      2/41.94      2/42.78      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.8%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          667          689          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.511N     P=0.205      P=0.218      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.513N     P=0.228      P=0.232      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.506N     P=0.233      P=0.234      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.221      P=0.230      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.503N     P=0.231      P=0.234      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.500N     P=0.247      P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.99      0/42.93      0/40.96     |0/43.71      2/41.94      2/42.78      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         4.8%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          608          ---          ---         |---          667          689          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.574N     P=0.500      (e)          (e)         |P=0.511N     P=0.205      P=0.218      (e)          | 
|POLY 3             |     P=0.552N     P=0.515      (e)          (e)         |P=0.513N     P=0.228      P=0.232      (e)          | 
|POLY 1.5           |     P=0.560N     P=0.507      (e)          (e)         |P=0.506N     P=0.233      P=0.234      (e)          | 
|POLY 6             |     P=0.538N     P=0.531      (e)          (e)         |P=0.523N     P=0.221      P=0.230      (e)          | 
|LOGISTIC REGRESSION|     P=0.563N     P=0.505      (e)          (e)         |P=0.503N     P=0.231      P=0.234      (e)          | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.500N     P=0.247      P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |2/43.71      0/41.70      3/42.20      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         7.1%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    0/24 (0%)    2/29 (7%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.308N     P=0.311N     P=0.446      P=0.259N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.248N     P=0.484      P=0.243N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.242N     P=0.486      P=0.240N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.256N     P=0.480      P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.308N     (e)          P=0.468      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.247N     P=0.490      P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    2/49 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.91      2/43.12      2/41.21     |0/43.71      1/41.84      2/42.10      3/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         4.6%         4.9%        |0.0%         2.4%         4.8%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          311          680          661         |---          696          725          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266      P=0.240      P=0.313      P=0.283     |P=0.065      P=0.472      P=0.215      P=0.109      | 
|POLY 3             |     P=0.252      P=0.259      P=0.255      P=0.244     |P=0.060      P=0.491      P=0.229      P=0.115      | 
|POLY 1.5           |     P=0.245      P=0.248      P=0.244      P=0.240     |P=0.061      P=0.496      P=0.230      P=0.117      | 
|POLY 6             |     P=0.267      P=0.279      P=0.273      P=0.255     |P=0.059      P=0.484      P=0.226      P=0.113      | 
|LOGISTIC REGRESSION|     P=0.247      P=0.318      P=0.262      P=0.245     |P=0.061      P=0.496      P=0.216      P=0.120      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.242      P=0.247     |P=0.062      P=0.500      P=0.242      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    5/49 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.91      2/43.12      2/41.21     |2/43.71      1/41.84      5/42.22      3/42.95      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         4.6%         4.9%        |4.6%         2.4%         11.8%        7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    1/27 (4%)   |2/33 (6%)    0/24 (0%)    3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          311          680          661         |731 (T)      696          698          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266      P=0.240      P=0.313      P=0.283     |P=0.279      P=0.590N     P=0.175      P=0.461      | 
|POLY 3             |     P=0.252      P=0.259      P=0.255      P=0.244     |P=0.280      P=0.515N     P=0.201      P=0.492      | 
|POLY 1.5           |     P=0.245      P=0.248      P=0.244      P=0.240     |P=0.281      P=0.507N     P=0.203      P=0.496      | 
|POLY 6             |     P=0.267      P=0.279      P=0.273      P=0.255     |P=0.278      P=0.527N     P=0.198      P=0.486      | 
|LOGISTIC REGRESSION|     P=0.247      P=0.318      P=0.262      P=0.245     |P=0.273      P=0.537N     P=0.185      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.242      P=0.247     |P=0.282      P=0.500N     P=0.210      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/49 (2%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/39.84      3/42.57      1/42.98      2/40.96     |1/42.75      1/41.70      1/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         7.1%         2.3%         4.9%        |2.3%         2.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   0/26 (0%)    2/27 (7%)   |1/33 (3%)    1/24 (4%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      717          729 (T)     |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605      P=0.445      P=0.685N     P=0.605     |P=0.320N     P=0.689      P=0.733      P=0.519N     | 
|POLY 3             |     P=0.539      P=0.329      P=0.744N     P=0.510     |P=0.312N     P=0.755      P=0.759      P=0.501N     | 
|POLY 1.5           |     P=0.531      P=0.315      P=0.754N     P=0.503     |P=0.311N     P=0.760      P=0.759      P=0.498N     | 
|POLY 6             |     P=0.557      P=0.355      P=0.727N     P=0.525     |P=0.315N     P=0.747      P=0.756      P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.597      P=0.445      P=0.695N     P=0.605     |P=0.320N     P=0.689      P=0.733      (e)          | 
|COCH-ARM / FISHERS |     P=0.525      P=0.309      P=0.747      P=0.500     |P=0.309N     P=0.747N     P=0.753N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    3/49 (6%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/39.84      4/42.63      3/42.96      0/40.96     |1/42.75      0/41.70      0/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         9.4%         7.0%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   2/26 (8%)    0/27 (0%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      714          722          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168N     P=0.312      P=0.414      P=0.440N    |P=0.313N     P=0.564N     P=0.526N     P=0.519N     | 
|POLY 3             |     P=0.218N     P=0.199      P=0.332      P=0.494N    |P=0.298N     P=0.505N     P=0.502N     P=0.501N     | 
|POLY 1.5           |     P=0.227N     P=0.187      P=0.316      P=0.498N    |P=0.301N     P=0.500N     P=0.501N     P=0.498N     | 
|POLY 6             |     P=0.199N     P=0.223      P=0.359      P=0.486N    |P=0.293N     P=0.512N     P=0.504N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.174N     P=0.293      P=0.432      (e)         |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.233N     P=0.181      P=0.301      P=0.500N    |P=0.304N     P=0.495N     P=0.500N     P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   4/49 (8%)    2/50 (4%)   |2/49 (4%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/39.84      7/42.63      4/43.00      2/40.96     |2/42.75      1/41.70      1/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         16.4%        9.3%         4.9%        |4.7%         2.4%         2.4%         0.0%         | 
|TERMINAL (d)       |     2/20 (10%)   6/29 (21%)   2/26 (8%)    2/27 (7%)   |2/33 (6%)    1/24 (4%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      714          717          729 (T)     |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.236N     P=0.200      P=0.484      P=0.584N    |P=0.162N     P=0.611N     P=0.545N     P=0.259N     | 
|POLY 3             |     P=0.319N     P=0.094      P=0.372      P=0.685N    |P=0.152N     P=0.509N     P=0.503N     P=0.238N     | 
|POLY 1.5           |     P=0.333N     P=0.085      P=0.351      P=0.691N    |P=0.152N     P=0.500N     P=0.502N     P=0.235N     | 
|POLY 6             |     P=0.291N     P=0.113      P=0.408      P=0.670N    |P=0.152N     P=0.522N     P=0.508N     P=0.242N     | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.189      P=0.497      P=0.584N    |P=0.162N     P=0.611N     P=0.545N     (e)          | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.080      P=0.329      P=0.691N    |P=0.151N     P=0.492N     P=0.500N     P=0.242N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   5/48 (10%)   6/50 (12%)  |0/49 (0%)    3/49 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/39.84      8/42.69      5/42.92      6/42.22     |0/43.46      3/41.03      1/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        18.7%        11.7%        14.2%       |0.0%         7.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     4/20 (20%)   7/29 (24%)   3/26 (12%)   3/27 (11%)  |0/33 (0%)    2/24 (8%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      608          694          558         |---          675          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.555N     P=0.375      P=0.606N     P=0.507     |P=0.375N     P=0.085      P=0.474      (e)          | 
|POLY 3             |     P=0.500      P=0.209      P=0.547      P=0.405     |P=0.381N     P=0.108      P=0.496      (e)          | 
|POLY 1.5           |     P=0.478      P=0.186      P=0.515      P=0.386     |P=0.371N     P=0.113      P=0.499      (e)          | 
|POLY 6             |     P=0.541      P=0.255      P=0.596      P=0.446     |P=0.395N     P=0.102      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.475      P=0.315      P=0.584N     P=0.385     |P=0.372N     P=0.105      P=0.474      (e)          | 
|COCH-ARM / FISHERS |     P=0.457      P=0.168      P=0.474      P=0.370     |P=0.360N     P=0.121      P=0.505      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/49 (6%)    1/48 (2%)    3/50 (6%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      3/42.56      1/42.77      3/40.96     |0/43.46      0/40.82      0/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         7.1%         2.3%         7.3%        |0.0%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    2/29 (7%)    1/26 (4%)    3/27 (11%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          652          729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202      P=0.185      P=0.552      P=0.177     |P=0.204      (e)          (e)          P=0.481      | 
|POLY 3             |     P=0.177      P=0.130      P=0.514      P=0.123     |P=0.199      (e)          (e)          P=0.496      | 
|POLY 1.5           |     P=0.171      P=0.122      P=0.504      P=0.120     |P=0.200      (e)          (e)          P=0.500      | 
|POLY 6             |     P=0.190      P=0.147      P=0.529      P=0.130     |P=0.198      (e)          (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.176      P=0.135      P=0.552      P=0.177     |(e)          (e)          (e)          P=0.481      | 
|COCH-ARM / FISHERS |     P=0.167      P=0.117      P=0.490      P=0.121     |P=0.201      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    10/49 (20%)  6/48 (13%)   9/50 (18%)  |0/49 (0%)    3/49 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/39.84      10/42.98     6/42.92      9/42.22     |0/43.46      3/41.03      1/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        23.3%        14.0%        21.3%       |0.0%         7.3%         2.4%         2.4%         | 
|TERMINAL (d)       |     4/20 (20%)   8/29 (28%)   4/26 (15%)   6/27 (22%)  |0/33 (0%)    2/24 (8%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      608          694          558         |---          675          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.208      P=0.550      P=0.224     |P=0.582      P=0.085      P=0.474      P=0.481      | 
|POLY 3             |     P=0.232      P=0.092      P=0.416      P=0.134     |P=0.575      P=0.108      P=0.496      P=0.496      | 
|POLY 1.5           |     P=0.215      P=0.078      P=0.384      P=0.123     |P=0.586      P=0.113      P=0.499      P=0.500      | 
|POLY 6             |     P=0.265      P=0.124      P=0.468      P=0.160     |P=0.560      P=0.102      P=0.492      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.212      P=0.140      P=0.584      P=0.134     |P=0.583      P=0.105      P=0.474      P=0.481      | 
|COCH-ARM / FISHERS |     P=0.201      P=0.068      P=0.344      P=0.117     |P=0.598      P=0.121      P=0.505      P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.57      0/43.82      0/40.96     |2/44.68      2/41.91      2/42.62      3/42.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |4.5%         4.8%         4.7%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |1/33 (3%)    1/24 (4%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |234          675          712          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.574      (e)          (e)         |P=0.382      P=0.630      P=0.654      P=0.472      | 
|POLY 3             |     P=0.553N     P=0.513      (e)          (e)         |P=0.374      P=0.671      P=0.677      P=0.480      | 
|POLY 1.5           |     P=0.560N     P=0.506      (e)          (e)         |P=0.379      P=0.680      P=0.682      P=0.487      | 
|POLY 6             |     P=0.539N     P=0.527      (e)          (e)         |P=0.370      P=0.658      P=0.671      P=0.472      | 
|LOGISTIC REGRESSION|     (e)          P=0.574      (e)          (e)         |P=0.388      P=0.697      P=0.670N     P=0.500      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.387      P=0.691N     P=0.691N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.57      0/43.82      0/40.96     |3/44.68      2/41.91      2/42.62      3/42.77      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |6.7%         4.8%         4.7%         7.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    1/24 (4%)    1/29 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |234          675          712          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.574      (e)          (e)         |P=0.534      P=0.590N     P=0.550N     P=0.630      | 
|POLY 3             |     P=0.553N     P=0.513      (e)          (e)         |P=0.533      P=0.529N     P=0.521N     P=0.642      | 
|POLY 1.5           |     P=0.560N     P=0.506      (e)          (e)         |P=0.536      P=0.517N     P=0.516N     P=0.649      | 
|POLY 6             |     P=0.539N     P=0.527      (e)          (e)         |P=0.529      P=0.545N     P=0.529N     P=0.635      | 
|LOGISTIC REGRESSION|     (e)          P=0.574      (e)          (e)         |P=0.546      P=0.494N     P=0.476N     P=0.662N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.544      P=0.500N     P=0.500N     P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |16/50 (32%)  13/50 (26%)  20/50 (40%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |16/44.85     13/43.11     20/44.11     21/43.44     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |35.7%        30.2%        45.3%        48.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |13/33 (39%)  7/24 (29%)   13/29 (45%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |458          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.083      P=0.528      P=0.161      P=0.113      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.065      P=0.372N     P=0.235      P=0.156      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.073      P=0.352N     P=0.243      P=0.176      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.056      P=0.399N     P=0.231      P=0.135      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.072      P=0.374N     P=0.233      P=0.158      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.088      P=0.330N     P=0.266      P=0.204      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |17/50 (34%)  13/50 (26%)  20/50 (40%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |17/44.85     13/43.11     20/44.11     21/43.44     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |37.9%        30.2%        45.3%        48.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |14/33 (42%)  7/24 (29%)   13/29 (45%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |458          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.112      P=0.570N     P=0.211      P=0.157      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.092      P=0.293N     P=0.308      P=0.215      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.103      P=0.275N     P=0.315      P=0.238      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.082      P=0.316N     P=0.304      P=0.190      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.100      P=0.298N     P=0.301      P=0.214      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.120      P=0.257N     P=0.339      P=0.268      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |19/50 (38%)  14/50 (28%)  22/50 (44%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     2/39.84      2/42.65      1/43.82      0/40.96     |19/45.82     14/43.32     22/44.18     22/43.68     | 
|POLY-3 PERCENT (g) |     5.0%         4.7%         2.3%         0.0%        |41.5%        32.3%        49.8%        50.4%        | 
|TERMINAL (d)       |     2/20 (10%)   1/29 (3%)    1/26 (4%)    0/27 (0%)   |15/33 (46%)  7/24 (29%)   14/29 (48%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     729 (T)      708          729 (T)      ---         |234          608          570          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.553N     P=0.408N     P=0.174N    |P=0.150      P=0.501N     P=0.209      P=0.220      | 
|POLY 3             |     P=0.122N     P=0.670N     P=0.467N     P=0.230N    |P=0.112      P=0.248N     P=0.278      P=0.260      | 
|POLY 1.5           |     P=0.124N     P=0.683N     P=0.482N     P=0.235N    |P=0.126      P=0.229N     P=0.291      P=0.288      | 
|POLY 6             |     P=0.117N     P=0.642N     P=0.442N     P=0.221N    |P=0.101      P=0.267N     P=0.273      P=0.235      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.578N     P=0.408N     (e)         |P=0.141      P=0.207N     P=0.320      P=0.317      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.157      P=0.198N     P=0.342      P=0.342      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      1/41.46     |0/43.71      2/42.37      1/42.74      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         2.4%        |0.0%         4.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          578         |---          571          680          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.542      P=0.278      (e)          P=0.482     |P=0.471N     P=0.228      P=0.500      (e)          | 
|POLY 3             |     P=0.560      P=0.255      (e)          P=0.508     |P=0.472N     P=0.230      P=0.496      (e)          | 
|POLY 1.5           |     P=0.548      P=0.245      (e)          P=0.503     |P=0.466N     P=0.234      P=0.497      (e)          | 
|POLY 6             |     P=0.582      P=0.273      (e)          P=0.518     |P=0.481N     P=0.224      P=0.493      (e)          | 
|LOGISTIC REGRESSION|     P=0.541      P=0.234      (e)          P=0.519     |P=0.459N     P=0.239      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      2/41.67     |0/43.71      3/42.37      2/43.42      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         4.8%        |0.0%         7.1%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          578         |---          571          499          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.255      P=0.278      (e)          P=0.254     |P=0.420N     P=0.100      P=0.240      (e)          | 
|POLY 3             |     P=0.263      P=0.255      (e)          P=0.247     |P=0.423N     P=0.113      P=0.236      (e)          | 
|POLY 1.5           |     P=0.254      P=0.245      (e)          P=0.241     |P=0.416N     P=0.116      P=0.236      (e)          | 
|POLY 6             |     P=0.280      P=0.273      (e)          P=0.259     |P=0.434N     P=0.108      P=0.234      (e)          | 
|LOGISTIC REGRESSION|     P=0.251      P=0.234      (e)          P=0.241     |P=0.406N     P=0.123      P=0.255      (e)          | 
|COCH-ARM / FISHERS |     P=0.247      P=0.247      (e)          P=0.247     |P=0.409N     P=0.121      P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.09      0/43.82      0/40.96     |0/43.71      1/42.22      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          571          ---          ---         |---          571          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.393N     P=0.278      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.383N     P=0.255      (e)          (e)         |P=0.574N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.395N     P=0.245      (e)          (e)         |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.362N     P=0.273      (e)          (e)         |P=0.579N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.406N     P=0.234      (e)          (e)         |P=0.570N     P=0.488      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  35/50 (70%)  39/50 (78%)  32/50 (64%) |31/49 (63%)  29/50 (58%)  24/49 (49%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     35/45.87     35/45.18     39/48.10     32/45.64    |31/45.50     29/45.48     24/43.58     30/45.10     | 
|POLY-3 PERCENT (g) |     76.3%        77.5%        81.1%        70.1%       |68.1%        63.8%        55.1%        66.5%        | 
|TERMINAL (d)       |     14/20 (70%)  24/29 (83%)  20/26 (77%)  19/27 (70%) |24/33 (73%)  15/24 (63%)  18/29 (62%)  19/30 (63%)  | 
|FIRST INCIDENCE    |     477          485          519          332         |458          408          617          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.069N     P=0.268N     P=0.105N    |P=0.497N     P=0.236      P=0.281N     P=0.461      | 
|POLY 3             |     P=0.263N     P=0.550      P=0.371      P=0.324N    |P=0.469N     P=0.411N     P=0.140N     P=0.525N     | 
|POLY 1.5           |     P=0.279N     P=0.553      P=0.310      P=0.330N    |P=0.445N     P=0.383N     P=0.126N     P=0.491N     | 
|POLY 6             |     P=0.238N     P=0.560      P=0.470      P=0.311N    |P=0.489N     P=0.455N     P=0.166N     P=0.555N     | 
|LOGISTIC REGRESSION|     P=0.297N     P=0.492N     P=0.352      P=0.322N    |P=0.426N     P=0.412N     P=0.108N     P=0.491N     | 
|COCH-ARM / FISHERS |     P=0.309N     P=0.586N     P=0.247      P=0.335N    |P=0.409N     P=0.371N     P=0.111N     P=0.449N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      1/43.82      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    1/26 (4%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.417N     P=0.327      P=0.552      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.444N     P=0.252      P=0.519      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.454N     P=0.244      P=0.510      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.425N     P=0.270      P=0.533      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.430N     P=0.291      P=0.552      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      1/43.82      1/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.3%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    1/26 (4%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.327      P=0.552      P=0.560     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.514      P=0.252      P=0.519      P=0.506     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.505      P=0.244      P=0.510      P=0.502     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.534      P=0.270      P=0.533      P=0.514     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.539      P=0.291      P=0.552      P=0.560     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.247      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.65      2/43.82      2/41.21     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         4.6%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          708          729 (T)      661         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.284      P=0.327      P=0.297      P=0.283     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.254      P=0.252      P=0.259      P=0.244     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247      P=0.244      P=0.249      P=0.240     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.270      P=0.270      P=0.276      P=0.255     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.253      P=0.291      P=0.297      P=0.245     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.247      P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   4/50 (8%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      8/42.87      4/44.35      4/41.85     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        18.7%        9.0%         9.6%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200N     P=0.535      P=0.342N     P=0.375N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.254N     P=0.315      P=0.440N     P=0.476N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.267N     P=0.292      P=0.468N     P=0.490N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.230N     P=0.361      P=0.396N     P=0.446N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.264N     P=0.414      P=0.427N     P=0.488N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.277      P=0.500N     P=0.500N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    4/50 (8%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/40.22      0/42.57      4/43.85      2/40.96     |1/43.95      0/41.70      1/42.63      1/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         9.1%         4.9%        |2.3%         0.0%         2.4%         2.4%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    3/26 (12%)   2/27 (7%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     624          ---          722          729 (T)     |666          ---          710          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.192N     P=0.465      P=0.609N    |P=0.527      P=0.510N     P=0.742      P=0.741      | 
|POLY 3             |     P=0.396      P=0.224N     P=0.377      P=0.688N    |P=0.537      P=0.510N     P=0.754      P=0.754      | 
|POLY 1.5           |     P=0.399      P=0.232N     P=0.359      P=0.692N    |P=0.538      P=0.505N     P=0.756      P=0.757      | 
|POLY 6             |     P=0.396      P=0.211N     P=0.408      P=0.676N    |P=0.536      P=0.519N     P=0.750      P=0.748      | 
|LOGISTIC REGRESSION|     P=0.428      P=0.236N     P=0.428      P=0.673N    |P=0.536      P=0.497N     P=0.762      P=0.760      | 
|COCH-ARM / FISHERS |     P=0.404      P=0.247N     P=0.339      P=0.691N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/41.38      1/42.65      5/44.13      3/41.81     |1/43.95      1/41.76      1/42.63      1/42.54      | 
|POLY-3 PERCENT (g) |     14.5%        2.3%         11.3%        7.2%        |2.3%         2.4%         2.4%         2.4%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    3/26 (12%)   2/27 (7%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     612          708          655          390         |666          717          710          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285N     P=0.035N*    P=0.338N     P=0.194N    |P=0.617      P=0.727      P=0.742      P=0.741      | 
|POLY 3             |     P=0.341N     P=0.050N     P=0.455N     P=0.235N    |P=0.626      P=0.749      P=0.754      P=0.754      | 
|POLY 1.5           |     P=0.340N     P=0.054N     P=0.475N     P=0.239N    |P=0.629      P=0.755      P=0.756      P=0.757      | 
|POLY 6             |     P=0.345N     P=0.043N*    P=0.424N     P=0.226N    |P=0.620      P=0.740      P=0.750      P=0.748      | 
|LOGISTIC REGRESSION|     P=0.343N     P=0.060N     P=0.489N     P=0.241N    |P=0.629      P=0.760      P=0.762      P=0.760      | 
|COCH-ARM / FISHERS |     P=0.341N     P=0.056N     P=0.500N     P=0.243N    |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/41.00      1/42.65      1/44.10      1/41.81     |0/43.71      1/41.76      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     9.8%         2.3%         2.3%         2.4%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     612          708          655          390         |---          717          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.127N     P=0.124N     P=0.173N    |P=0.575N     P=0.450      (e)          (e)          | 
|POLY 3             |     P=0.133N     P=0.166N     P=0.157N     P=0.171N    |P=0.575N     P=0.491      (e)          (e)          | 
|POLY 1.5           |     P=0.133N     P=0.174N     P=0.167N     P=0.176N    |P=0.571N     P=0.496      (e)          (e)          | 
|POLY 6             |     P=0.134N     P=0.151N     P=0.142N     P=0.164N    |P=0.580N     P=0.484      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.134N     P=0.183N     P=0.209N     P=0.158N    |P=0.571N     P=0.482      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.181N     P=0.181N     P=0.181N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/40.31      0/42.57      0/43.82      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     638          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103N     P=0.191N     P=0.184N     P=0.221N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.116N     P=0.225N     P=0.219N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.114N     P=0.232N     P=0.227N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.120N     P=0.212N     P=0.206N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.116N     P=0.239N     P=0.247N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/40.08      6/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     10.0%        14.0%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   5/29 (17%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.107N     P=0.601      P=0.233N     P=0.248N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.136N     P=0.410      P=0.291N     P=0.319N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.144N     P=0.387      P=0.312N     P=0.330N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.123N     P=0.456      P=0.258N     P=0.297N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.144N     P=0.522      P=0.298N     P=0.328N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.151N     P=0.370      P=0.339N     P=0.339N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/39.95      0/42.57      3/44.10      1/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         6.8%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    2/26 (8%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     701          ---          655          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.503N     P=0.169N     P=0.622      P=0.414N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.561N     P=0.223N     P=0.545      P=0.491N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.558N     P=0.231N     P=0.524      P=0.497N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.563N     P=0.208N     P=0.578      P=0.478N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.538N     P=0.188N     P=0.583      P=0.439N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.247N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      7/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        16.4%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051N     P=0.611N     P=0.131N     P=0.146N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.068N     P=0.421      P=0.178N     P=0.201N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.073N     P=0.397      P=0.195N     P=0.210N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.060N     P=0.469      P=0.152N     P=0.184N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.529      P=0.188N     P=0.210N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.079N     P=0.380      P=0.218N     P=0.218N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.28      7/42.78      2/44.35      2/41.59     |0/43.71      1/42.30      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.4%        16.4%        4.5%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/20 (15%)   6/29 (21%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          673          655          552         |---          540          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051N     P=0.611N     P=0.131N     P=0.146N    |P=0.567N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.068N     P=0.421      P=0.178N     P=0.201N    |P=0.573N     P=0.493      (e)          (e)          | 
|POLY 1.5           |     P=0.073N     P=0.397      P=0.195N     P=0.210N    |P=0.570N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.060N     P=0.469      P=0.152N     P=0.184N    |P=0.578N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.073N     P=0.529      P=0.188N     P=0.210N    |P=0.573N     P=0.476      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.079N     P=0.380      P=0.218N     P=0.218N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  32/50 (64%)  34/50 (68%)  34/50 (68%) |                                                    | 
|POLY-3 RATE (b)    |     36/45.75     32/45.25     34/45.67     34/43.31    |                                                    | 
|POLY-3 PERCENT (g) |     78.7%        70.7%        74.5%        78.5%       |                                                    | 
|TERMINAL (d)       |     18/20 (90%)  21/29 (72%)  23/26 (89%)  25/27 (93%) |                                                    | 
|FIRST INCIDENCE    |     502          571          584          533         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.148N     P=0.017N*    P=0.046N*    P=0.060N    |                                                    | 
|POLY 3             |     P=0.460      P=0.252N     P=0.402N     P=0.604N    |                                                    | 
|POLY 1.5           |     P=0.536      P=0.268N     P=0.406N     P=0.519N    |                                                    | 
|POLY 6             |     P=0.349      P=0.202N     P=0.397N     P=0.538     |                                                    | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.174N     P=0.182N     P=0.362N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.459N     P=0.260N     P=0.414N     P=0.414N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    4/49 (8%)    2/50 (4%)   |2/50 (4%)    4/50 (8%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/40.17      4/42.85      4/43.04      2/41.13     |2/44.04      4/41.76      4/42.84      3/42.56      | 
|POLY-3 PERCENT (g) |     2.5%         9.3%         9.3%         4.9%        |4.5%         9.6%         9.3%         7.1%         | 
|TERMINAL (d)       |     0/20 (0%)    3/29 (10%)   2/26 (8%)    1/27 (4%)   |1/33 (3%)    3/24 (13%)   3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     638          652          712          684         |638          717          652          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566N     P=0.281      P=0.291      P=0.565     |P=0.470      P=0.224      P=0.301      P=0.462      | 
|POLY 3             |     P=0.532      P=0.198      P=0.199      P=0.508     |P=0.462      P=0.312      P=0.324      P=0.484      | 
|POLY 1.5           |     P=0.524      P=0.187      P=0.187      P=0.503     |P=0.472      P=0.325      P=0.329      P=0.492      | 
|POLY 6             |     P=0.554      P=0.221      P=0.221      P=0.522     |P=0.448      P=0.293      P=0.316      P=0.473      | 
|LOGISTIC REGRESSION|     P=0.538      P=0.196      P=0.216      P=0.505     |P=0.466      P=0.303      P=0.328      P=0.485      | 
|COCH-ARM / FISHERS |     P=0.520      P=0.181      P=0.175      P=0.500     |P=0.481      P=0.339      P=0.339      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    5/49 (10%)   3/50 (6%)   |3/50 (6%)    5/50 (10%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/40.17      4/42.85      5/43.61      3/41.13     |3/44.42      5/41.76      4/42.84      3/42.56      | 
|POLY-3 PERCENT (g) |     2.5%         9.3%         11.5%        7.3%        |6.8%         12.0%        9.3%         7.1%         | 
|TERMINAL (d)       |     0/20 (0%)    3/29 (10%)   2/26 (8%)    2/27 (7%)   |1/33 (3%)    4/24 (17%)   3/29 (10%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     638          652          551          684         |625          717          652          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.408      P=0.281      P=0.180      P=0.387     |P=0.495N     P=0.231      P=0.457      P=0.622      | 
|POLY 3             |     P=0.340      P=0.198      P=0.120      P=0.313     |P=0.504N     P=0.322      P=0.480      P=0.643      | 
|POLY 1.5           |     P=0.333      P=0.187      P=0.109      P=0.308     |P=0.493N     P=0.340      P=0.488      P=0.653      | 
|POLY 6             |     P=0.359      P=0.221      P=0.140      P=0.327     |P=0.521N     P=0.296      P=0.468      P=0.628      | 
|LOGISTIC REGRESSION|     P=0.336      P=0.196      P=0.096      P=0.318     |P=0.494N     P=0.333      P=0.496      P=0.659      | 
|COCH-ARM / FISHERS |     P=0.331      P=0.181      P=0.098      P=0.309     |P=0.482N     P=0.357      P=0.500      P=0.661N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      1/42.93      0/40.96     |2/43.74      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    0/27 (0%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |722          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.722      (e)          P=0.552      (e)         |P=0.124N     P=0.311N     P=0.268N     P=0.261N     | 
|POLY 3             |     P=0.693      (e)          P=0.515      (e)         |P=0.110N     P=0.248N     P=0.243N     P=0.243N     | 
|POLY 1.5           |     P=0.691      (e)          P=0.506      (e)         |P=0.112N     P=0.242N     P=0.241N     P=0.240N     | 
|POLY 6             |     P=0.699      (e)          P=0.529      (e)         |P=0.107N     P=0.257N     P=0.247N     P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.552      (e)         |P=0.121N     P=0.274N     P=0.255N     P=0.254N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.495      (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue                                                                                                                           | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/43.82      1/41.46     |0/43.71      2/41.84      1/42.74      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |0.0%         4.8%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          578         |---          695          680          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189      (e)          (e)          P=0.482     |P=0.473N     P=0.194      P=0.500      (e)          | 
|POLY 3             |     P=0.201      (e)          (e)          P=0.508     |P=0.473N     P=0.227      P=0.496      (e)          | 
|POLY 1.5           |     P=0.200      (e)          (e)          P=0.503     |P=0.467N     P=0.232      P=0.497      (e)          | 
|POLY 6             |     P=0.203      (e)          (e)          P=0.518     |P=0.482N     P=0.220      P=0.493      (e)          | 
|LOGISTIC REGRESSION|     P=0.207      (e)          (e)          P=0.519     |P=0.464N     P=0.221      P=0.501      (e)          | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   3/50 (6%)    7/50 (14%)   13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |6/44.18      3/41.90      7/44.02      13/43.28     | 
|POLY-3 PERCENT (g) |                                                        |13.6%        7.2%         15.9%        30.0%        | 
|TERMINAL (d)       |                                                        |4/33 (12%)   1/24 (4%)    5/29 (17%)   8/30 (27%)   | 
|FIRST INCIDENCE    |                                                        |624          694          433          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.011 *    P=0.379N     P=0.419      P=0.047 *    | 
|POLY 3             |                                                        |P=0.008 **   P=0.268N     P=0.497      P=0.051      | 
|POLY 1.5           |                                                        |P=0.008 **   P=0.255N     P=0.499      P=0.056      | 
|POLY 6             |                                                        |P=0.008 **   P=0.289N     P=0.487      P=0.046 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.009 **   P=0.272N     P=0.502      P=0.050      | 
|COCH-ARM / FISHERS |                                                        |P=0.010 *    P=0.243N     P=0.500      P=0.062      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   3/50 (6%)    7/50 (14%)   14/50 (28%)  | 
|POLY-3 RATE (b)    |                                                        |6/44.18      3/41.90      7/44.02      14/43.80     | 
|POLY-3 PERCENT (g) |                                                        |13.6%        7.2%         15.9%        32.0%        | 
|TERMINAL (d)       |                                                        |4/33 (12%)   1/24 (4%)    5/29 (17%)   8/30 (27%)   | 
|FIRST INCIDENCE    |                                                        |624          694          433          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.006 **   P=0.379N     P=0.419      P=0.031 *    | 
|POLY 3             |                                                        |P=0.004 **   P=0.268N     P=0.497      P=0.033 *    | 
|POLY 1.5           |                                                        |P=0.004 **   P=0.255N     P=0.499      P=0.035 *    | 
|POLY 6             |                                                        |P=0.004 **   P=0.289N     P=0.487      P=0.030 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.004 **   P=0.272N     P=0.502      P=0.034 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.005 **   P=0.243N     P=0.500      P=0.039 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  21/50 (42%)  19/50 (38%)  17/50 (34%) |21/50 (42%)  23/50 (46%)  22/50 (44%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     22/46.05     21/44.98     19/46.40     17/43.33    |21/46.50     23/45.82     22/46.05     15/44.82     | 
|POLY-3 PERCENT (g) |     47.8%        46.7%        41.0%        39.2%       |45.2%        50.2%        47.8%        33.5%        | 
|TERMINAL (d)       |     4/20 (20%)   13/29 (45%)  6/26 (23%)   9/27 (33%)  |11/33 (33%)  8/24 (33%)   10/29 (35%)  8/30 (27%)   | 
|FIRST INCIDENCE    |     502          493          528          552         |519          366          421          514          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.105N     P=0.207N     P=0.146N     P=0.128N    |P=0.159N     P=0.183      P=0.372      P=0.263N     | 
|POLY 3             |     P=0.205N     P=0.543N     P=0.324N     P=0.271N    |P=0.108N     P=0.391      P=0.483      P=0.175N     | 
|POLY 1.5           |     P=0.185N     P=0.533N     P=0.332N     P=0.245N    |P=0.098N     P=0.414      P=0.492      P=0.159N     | 
|POLY 6             |     P=0.228N     P=0.542N     P=0.312N     P=0.301N    |P=0.129N     P=0.348      P=0.457      P=0.204N     | 
|LOGISTIC REGRESSION|     P=0.157N     P=0.509N     P=0.431N     P=0.208N    |P=0.090N     P=0.420      P=0.496      P=0.151N     | 
|COCH-ARM / FISHERS |     P=0.158N     P=0.500N     P=0.342N     P=0.206N    |P=0.090N     P=0.420      P=0.500      P=0.149N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.13      0/42.57      3/43.89      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         6.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     650          ---          712          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.463N     P=0.421      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.505N     P=0.488N     P=0.338      P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.503N     P=0.495N     P=0.323      P=0.499N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.504N     P=0.475N     P=0.362      P=0.489N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.503N     P=0.357      P=0.500N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.13      0/42.57      3/43.89      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         6.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     650          ---          712          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.453N     P=0.463N     P=0.421      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.505N     P=0.488N     P=0.338      P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.503N     P=0.495N     P=0.323      P=0.499N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.504N     P=0.475N     P=0.362      P=0.489N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.491N     P=0.503N     P=0.357      P=0.500N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  47/50 (94%)  49/50 (98%)  46/50 (92%) |41/50 (82%)  39/50 (78%)  41/50 (82%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     48/48.66     47/47.50     49/49.16     46/48.35    |41/47.98     39/47.44     41/47.44     39/45.97     | 
|POLY-3 PERCENT (g) |     98.6%        99.0%        99.7%        95.1%       |85.5%        82.2%        86.4%        84.8%        | 
|TERMINAL (d)       |     20/20 (100%) 29/29 (100%) 26/26 (100%) 26/27 (96%) |29/33 (88%)  19/24 (79%)  25/29 (86%)  25/30 (83%)  | 
|FIRST INCIDENCE    |     477          485          519          332         |458          408          433          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.024N*    P=0.083N     P=0.087N    |P=0.504N     P=0.164      P=0.295      P=0.472      | 
|POLY 3             |     P=0.104N     P=0.905      P=0.805      P=0.315N    |P=0.522      P=0.437N     P=0.565      P=0.585N     | 
|POLY 1.5           |     P=0.155N     P=0.796N     P=0.628      P=0.314N    |P=0.515N     P=0.409N     P=0.570      P=0.504N     | 
|POLY 6             |     P=0.085N     P=0.997      P=0.995      P=0.332N    |P=0.463      P=0.471N     P=0.559      P=0.593      | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.757N     P=0.659      P=0.382N    |P=0.421N     P=0.432N     P=0.561      P=0.440N     | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.500N     P=0.500      P=0.339N    |P=0.406N     P=0.402N     P=0.602N     P=0.402N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  31/50 (62%)  30/50 (60%)  24/50 (48%) |28/50 (56%)  29/50 (58%)  27/50 (54%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     28/48.04     31/47.82     30/47.78     24/45.03    |28/47.92     29/46.72     27/47.10     22/46.91     | 
|POLY-3 PERCENT (g) |     58.3%        64.8%        62.8%        53.3%       |58.4%        62.1%        57.3%        46.9%        | 
|TERMINAL (d)       |     5/20 (25%)   16/29 (55%)  13/26 (50%)  12/27 (44%) |14/33 (42%)  11/24 (46%)  12/29 (41%)  11/30 (37%)  | 
|FIRST INCIDENCE    |     373          311          528          390         |234          366          421          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.118N     P=0.351N     P=0.315N     P=0.165N    |P=0.195N     P=0.191      P=0.469      P=0.315N     | 
|POLY 3             |     P=0.284N     P=0.325      P=0.404      P=0.390N    |P=0.104N     P=0.439      P=0.540N     P=0.177N     | 
|POLY 1.5           |     P=0.238N     P=0.331      P=0.406      P=0.344N    |P=0.100N     P=0.467      P=0.531N     P=0.166N     | 
|POLY 6             |     P=0.338N     P=0.327      P=0.410      P=0.442N    |P=0.117N     P=0.395      P=0.563N     P=0.201N     | 
|LOGISTIC REGRESSION|     P=0.176N     P=0.237      P=0.271      P=0.286N    |P=0.095N     P=0.514      P=0.490N     P=0.146N     | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.342      P=0.420      P=0.274N    |P=0.098N     P=0.500      P=0.500N     P=0.159N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                 VANADIUM PENTOXIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 49/50 (98%)  49/50 (98%) |47/50 (94%)  47/50 (94%)  46/50 (92%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     49/49.16     49/49.40    |47/50.00     47/49.48     46/49.01     45/48.46     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       99.7%        99.2%       |94.0%        95.0%        93.9%        92.9%        | 
|TERMINAL (d)       |     20/20 (100%) 29/29 (100%) 26/26 (100%) 27/27 (100%)|30/33 (91%)  22/24 (92%)  26/29 (90%)  27/30 (90%)  | 
|FIRST INCIDENCE    |     373          311          519          332         |234          366          421          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146N     (e)          P=0.051N     P=0.113N    |P=0.459N     P=0.083      P=0.347      P=0.456      | 
|POLY 3             |     P=0.530N     (e)          P=1.000N     P=0.930N    |P=0.448N     P=0.589      P=0.651N     P=0.572N     | 
|POLY 1.5           |     P=0.316N     (e)          P=0.936N     P=0.716N    |P=0.378N     P=0.621      P=0.640N     P=0.495N     | 
|POLY 6             |     P=0.995N     (e)          P=1.000N     P=1.000N    |P=0.496N     P=0.548      P=0.652N     P=0.627N     | 
|LOGISTIC REGRESSION|     P=0.252N     (e)          P=0.398N     P=0.538N    |P=0.249N     P=0.645N     P=0.519N     P=0.360N     | 
|COCH-ARM / FISHERS |     P=0.236N     (e)          P=0.500N     P=0.500N    |P=0.248N     P=0.661N     P=0.500N     P=0.357N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).