Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/13070

TDMS Study 61427-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:12:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:12:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                VANADIUM PENTOXIDE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Kidney                                 Nephropathy Chronic                                                                          
Larynx                                 Inflammation                                                                                 
                                       Inflammation Chronic                                                                         
Larynx: Respiratory Epithelium, Epiglottis                                                                                          
                                       Degeneration                                                                                 
                                       Hyperplasia                                                                                  
                                       Metaplasia                                                                                   
Liver                                  Hepatodiaphragmatic Nodule                                                                   
                                       Inflammation Granulomatous                                                                   
Liver: Portal                          Inflammation Chronic                                                                         
                                       Pigmentation                                                                                 
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia                                                                                   
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
                                       Pigmentation                                                                                 
Lung: Bronchiole                       Hyperplasia                                                                                  
                                       Metaplasia                                                                                   
Lung: Interstitium                     Fibrosis                                                                                     
Lymph Node, Bronchial                  Pigmentation                                                                                 
Lymph Node, Mediastinal                Inflammation Granulomatous                                                                   
Nose: Goblet Cell, Respiratory Epithelium                                                                                           
                                       Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Pancreas: Acinus                       Hyperplasia                                                                                  
Pancreas: Artery                       Inflammation                                                                                 
Skin                                   Cyst                                                                                         
Spleen                                 Fibrosis                                                                                     
                                       Hematopoietic Cell Proliferation                                                             
                                       Hemorrhage                                                                                   
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Vacuolization Cytoplasmic                                                                    
Brain                                  Hemorrhage                                                                                   
Kidney                                 Nephropathy Chronic                                                                          
Larynx                                 Inflammation Chronic                                                                         
Larynx: Respiratory Epithelium, Epiglottis                                                                                          
                                       Degeneration                                                                                 
                                       Hyperplasia                                                                                  
                                       Metaplasia                                                                                   
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 07                                                                                     TIME: 10:12:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: RENNE, ROGER                    MILLER, RODNEY                                                    CAS: 1314-62-1       
Liver                                  Clear Cell Focus                                                                             
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia                                                                                   
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
                                       Pigmentation                                                                                 
Lung: Bronchiole                       Hyperplasia                                                                                  
Lung: Interstitium                     Fibrosis                                                                                     
Lymph Node, Bronchial                  Pigmentation                                                                                 
Lymph Node, Mediastinal                Pigmentation                                                                                 
Mammary Gland: Epithelium              Hyperplasia                                                                                  
Nose                                   Inflammation                                                                                 
Nose: Goblet Cell, Respiratory Epithelium                                                                                           
                                       Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Ovary                                  Cyst                                                                                         
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Spleen                                 Accessory Spleen                                                                             
Stomach, Forestomach                   Ulcer                                                                                        
Tongue: Epithelium                     Hyperplasia                                                                                  
Uterus: Endometrium                    Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/40.13      0/42.57      0/42.93      1/41.56     |0/42.75      2/42.98      1/43.54      1/43.19      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         2.4%        |0.0%         4.7%         2.3%         2.3%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     652          ---          ---          538         |---          499          139          514          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.598      P=0.457N     P=0.447N     P=0.754N    |P=0.499      P=0.242      P=0.500      P=0.500      | 
|POLY 3             |     P=0.592      P=0.488N     P=0.487N     P=0.753N    |P=0.500      P=0.238      P=0.504      P=0.502      | 
|POLY 1.5           |     P=0.593      P=0.495N     P=0.495N     P=0.758N    |P=0.504      P=0.241      P=0.505      P=0.504      | 
|POLY 6             |     P=0.590      P=0.475N     P=0.474N     P=0.744N    |P=0.494      P=0.233      P=0.501      P=0.499      | 
|LOGISTIC REGRESSION|     P=0.598      P=0.503N     P=0.524N     P=0.752N    |P=0.472      P=0.198      (e)          P=0.471      | 
|COCH-ARM / FISHERS |     P=0.594      P=0.500N     P=0.505N     P=0.753N    |P=0.505      P=0.253      P=0.505      P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   5/50 (10%)   7/49 (14%)   5/50 (10%)  |9/49 (18%)   7/50 (14%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     9/42.03      5/43.54      7/44.47      5/42.28     |9/43.99      7/42.82      4/43.32      3/43.32      | 
|POLY-3 PERCENT (g) |     21.4%        11.5%        15.7%        11.8%       |20.5%        16.4%        9.2%         6.9%         | 
|TERMINAL (d)       |     2/20 (10%)   3/29 (10%)   3/26 (12%)   2/27 (7%)   |5/33 (15%)   4/24 (17%)   2/29 (7%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     589          493          519          561         |519          499          499          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175N     P=0.113N     P=0.250N     P=0.158N    |P=0.045N*    P=0.573N     P=0.171N     P=0.092N     | 
|POLY 3             |     P=0.217N     P=0.170N     P=0.344N     P=0.185N    |P=0.032N*    P=0.414N     P=0.119N     P=0.061N     | 
|POLY 1.5           |     P=0.219N     P=0.183N     P=0.372N     P=0.191N    |P=0.031N*    P=0.394N     P=0.115N     P=0.058N     | 
|POLY 6             |     P=0.212N     P=0.148N     P=0.304N     P=0.171N    |P=0.033N*    P=0.447N     P=0.128N     P=0.068N     | 
|LOGISTIC REGRESSION|     P=0.221N     P=0.201N     P=0.474N     P=0.195N    |P=0.031N*    P=0.378N     P=0.109N     P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.219N     P=0.194N     P=0.410N     P=0.194N    |P=0.031N*    P=0.376N     P=0.109N     P=0.056N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  8/50 (16%)   12/49 (24%)  10/50 (20%) |2/49 (4%)    2/50 (4%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     16/42.66     8/43.13      12/43.98     10/42.07    |2/42.75      2/41.76      1/42.57      5/42.68      | 
|POLY-3 PERCENT (g) |     37.5%        18.6%        27.3%        23.8%       |4.7%         4.8%         2.4%         11.7%        | 
|TERMINAL (d)       |     6/20 (30%)   6/29 (21%)   7/26 (27%)   6/27 (22%)  |2/33 (6%)    1/24 (4%)    0/29 (0%)    4/30 (13%)   | 
|FIRST INCIDENCE    |     561          584          519          629         |731 (T)      717          725          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.120N     P=0.012N*    P=0.097N     P=0.064N    |P=0.117      P=0.584      P=0.541N     P=0.181      | 
|POLY 3             |     P=0.200N     P=0.039N*    P=0.212N     P=0.124N    |P=0.114      P=0.686      P=0.502N     P=0.214      | 
|POLY 1.5           |     P=0.200N     P=0.045N*    P=0.238N     P=0.127N    |P=0.116      P=0.694      P=0.498N     P=0.220      | 
|POLY 6             |     P=0.196N     P=0.031N*    P=0.181N     P=0.114N    |P=0.113      P=0.673      P=0.507N     P=0.207      | 
|LOGISTIC REGRESSION|     P=0.187N     P=0.039N*    P=0.221N     P=0.115N    |P=0.110      P=0.635      P=0.531N     P=0.194      | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.050N     P=0.272N     P=0.127N    |P=0.117      P=0.684N     P=0.492N     P=0.226      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    2/49 (4%)    4/50 (8%)   |3/50 (6%)    6/50 (12%)   3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.90      3/43.72      2/43.38      4/42.33     |3/45.06      6/44.17      3/43.09      0/42.54      | 
|POLY-3 PERCENT (g) |     12.2%        6.9%         4.6%         9.5%        |6.7%         13.6%        7.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     636          493          655          578         |519          408          661          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.246N     P=0.128N     P=0.436N    |P=0.066N     P=0.232      P=0.637      P=0.135N     | 
|POLY 3             |     P=0.458N     P=0.319N     P=0.192N     P=0.478N    |P=0.063N     P=0.232      P=0.642      P=0.129N     | 
|POLY 1.5           |     P=0.461N     P=0.339N     P=0.207N     P=0.491N    |P=0.058N     P=0.239      P=0.649      P=0.124N     | 
|POLY 6             |     P=0.453N     P=0.286N     P=0.170N     P=0.451N    |P=0.070N     P=0.220      P=0.631      P=0.136N     | 
|LOGISTIC REGRESSION|     P=0.464N     P=0.366N     P=0.236N     P=0.501N    |P=0.049N*    P=0.247      P=0.645N     P=0.120N     | 
|COCH-ARM / FISHERS |     P=0.464N     P=0.357N     P=0.226N     P=0.500N    |P=0.054N     P=0.243      P=0.661N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    3/50 (6%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/43.71      3/42.25      1/42.07      1/42.54      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         7.1%         2.4%         2.4%         | 
|TERMINAL (d)       |                                                        |1/33 (3%)    1/24 (4%)    1/29 (3%)    1/30 (3%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      582          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.453N     P=0.229      P=0.733      P=0.741      | 
|POLY 3             |                                                        |P=0.456N     P=0.293      P=0.752      P=0.755      | 
|POLY 1.5           |                                                        |P=0.451N     P=0.300      P=0.753      P=0.758      | 
|POLY 6             |                                                        |P=0.464N     P=0.282      P=0.750      P=0.750      | 
|LOGISTIC REGRESSION|                                                        |P=0.450N     P=0.301      P=0.733      P=0.741      | 
|COCH-ARM / FISHERS |                                                        |P=0.445N     P=0.309      P=0.747      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.71      3/42.25      0/42.07      2/42.54      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         7.1%         0.0%         4.7%         | 
|TERMINAL (d)       |                                                        |2/33 (6%)    1/24 (4%)    0/29 (0%)    2/30 (7%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      582          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.482N     P=0.388      P=0.267N     P=0.661      | 
|POLY 3             |                                                        |P=0.482N     P=0.485      P=0.246N     P=0.684      | 
|POLY 1.5           |                                                        |P=0.479N     P=0.493      P=0.244N     P=0.689      | 
|POLY 6             |                                                        |P=0.486N     P=0.471      P=0.248N     P=0.677      | 
|LOGISTIC REGRESSION|                                                        |P=0.481N     P=0.488      (e)          P=0.661      | 
|COCH-ARM / FISHERS |                                                        |P=0.475N     P=0.500      P=0.253N     P=0.691N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     2/3 (67%)    1/2 (50%)    2/3 (67%)   |3/3 (100%)   0/0 (0%)     0/2 (0%)     3/3 (100%)   | 
|POLY-3 RATE (b)    |     0/1.00       2/3.00       1/1.73       2/3.00      |3/3.00       0/0.00       0/1.01       3/3.00       | 
|POLY-3 PERCENT (g) |     0.0%         66.7%        58.0%        66.7%       |100.0%       0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     0/1 (0%)     1/2 (50%)    0/0 (0%)     2/3 (67%)   |2/2 (100%)   0/0 (0%)     0/1 (0%)     2/2 (100%)   | 
|FIRST INCIDENCE    |     ---          709          680          729 (T)     |638          ---          ---          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.462      P=0.366      P=0.590      P=0.500     |P=0.567      (e)          P=0.180N     (e)          | 
|POLY 3             |     P=0.432      P=0.500      P=0.601      P=0.500     |(e)          (e)          P=0.233N     (e)          | 
|POLY 1.5           |     P=0.432      P=0.500      P=0.607      P=0.500     |(e)          (e)          P=0.172N     (e)          | 
|POLY 6             |     P=0.430      P=0.500      P=0.587      P=0.500     |(e)          (e)          P=0.238N     (e)          | 
|LOGISTIC REGRESSION|     P=0.429      (e)          P=0.985      P=0.500     |P=0.688      (e)          P=0.201N     (e)          | 
|COCH-ARM / FISHERS |     P=0.418      P=0.500      P=0.667      P=0.500     |P=0.681      (e)          P=0.100N     (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   7/49 (14%)   7/50 (14%)  |3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/41.34      7/44.35      7/44.24      7/42.44     |3/43.71      1/42.11      1/43.02      2/42.83      | 
|POLY-3 PERCENT (g) |     16.9%        15.8%        15.8%        16.5%       |6.9%         2.4%         2.3%         4.7%         | 
|TERMINAL (d)       |     4/20 (20%)   3/29 (10%)   4/26 (15%)   2/27 (7%)   |3/33 (9%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     477          485          528          558         |731 (T)      612          589          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.470N     P=0.444N     P=0.462N     P=0.485N    |P=0.480N     P=0.403N     P=0.343N     P=0.539N     | 
|POLY 3             |     P=0.548N     P=0.559N     P=0.561N     P=0.594N    |P=0.473N     P=0.318N     P=0.311N     P=0.509N     | 
|POLY 1.5           |     P=0.555N     P=0.589N     P=0.593N     P=0.608N    |P=0.474N     P=0.312N     P=0.309N     P=0.504N     | 
|POLY 6             |     P=0.530N     P=0.503N     P=0.509N     P=0.560N    |P=0.471N     P=0.329N     P=0.314N     P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.551      P=0.599      P=0.556      P=0.612     |P=0.474N     P=0.316N     P=0.309N     P=0.519N     | 
|COCH-ARM / FISHERS |     P=0.553      P=0.613N     P=0.597      P=0.613N    |P=0.474N     P=0.309N     P=0.309N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/40.80      0/42.57      2/43.55      0/40.96     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         4.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     561          ---          528          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.247N     P=0.661N     P=0.255N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.253N     P=0.227N     P=0.671N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.251N     P=0.233N     P=0.685N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.257N     P=0.216N     P=0.648N     P=0.230N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.246N     P=0.219N     P=0.616      P=0.216N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.247N     P=0.684      P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy Chronic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  42/50 (84%)  46/49 (94%)  47/50 (94%) |24/50 (48%)  21/50 (42%)  20/49 (41%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     36/44.96     42/47.06     46/47.81     47/48.29    |24/44.54     21/44.12     20/44.36     32/47.19     | 
|POLY-3 PERCENT (g) |     80.1%        89.2%        96.2%        97.3%       |53.9%        47.6%        45.1%        67.8%        | 
|TERMINAL (d)       |     17/20 (85%)  27/29 (93%)  26/26 (100%) 27/27 (100%)|20/33 (61%)  13/24 (54%)  13/29 (45%)  17/30 (57%)  | 
|FIRST INCIDENCE    |     561          485          519          332         |638          408          572          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.236      P=0.230N     P=0.548N     P=0.389     |P=0.053      P=0.352      P=0.456N     P=0.057      | 
|POLY 3             |     P<0.001 **   P=0.150      P=0.007 **   P=0.003 **  |P=0.058      P=0.350N     P=0.265N     P=0.118      | 
|POLY 1.5           |     P<0.001 **   P=0.117      P=0.004 **   P=0.002 **  |P=0.047 *    P=0.338N     P=0.283N     P=0.099      | 
|POLY 6             |     P=0.002 **   P=0.238      P=0.019 *    P=0.005 **  |P=0.077      P=0.375N     P=0.251N     P=0.151      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.134      P=0.010 *    P=0.002 **  |P=0.034 *    P=0.428N     P=0.316N     P=0.064      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.114      P=0.004 **   P=0.003 **  |P=0.039 *    P=0.344N     P=0.303N     P=0.079      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Cortex                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/40.85      0/42.57      0/42.93      0/40.96     |0/43.71      0/41.70      0/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     4.9%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     373          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.108N     P=0.211N     P=0.204N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.115N     P=0.228N     P=0.226N     P=0.236N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.114N     P=0.234N     P=0.234N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.120N     P=0.214N     P=0.213N     P=0.229N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.110N     P=0.183N     P=0.296N     P=0.186N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.253N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |0/43.71      0/41.70      1/42.52      2/42.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.4%         4.7%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          683          680          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.495      P=0.223      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.495      P=0.232      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.495      P=0.235      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.069      (e)          P=0.493      P=0.228      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.496      P=0.232      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.495      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/50 (6%)    2/50 (4%)    2/49 (4%)   |3/50 (6%)    6/49 (12%)   0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/39.49      3/42.65      2/43.96      2/40.41     |3/45.43      6/42.63      0/42.34      1/43.32      | 
|POLY-3 PERCENT (g) |     7.6%         7.0%         4.6%         5.0%        |6.6%         14.1%        0.0%         2.3%         | 
|TERMINAL (d)       |     1/20 (5%)    2/29 (7%)    0/26 (0%)    0/27 (0%)   |1/33 (3%)    3/24 (13%)   0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     677          709          703          661         |234          571          ---          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307N     P=0.487N     P=0.357N     P=0.416N    |P=0.087N     P=0.174      P=0.136N     P=0.321N     | 
|POLY 3             |     P=0.366N     P=0.627N     P=0.451N     P=0.489N    |P=0.083N     P=0.211      P=0.132N     P=0.322N     | 
|POLY 1.5           |     P=0.370N     P=0.642N     P=0.469N     P=0.497N    |P=0.079N     P=0.220      P=0.129N     P=0.316N     | 
|POLY 6             |     P=0.356N     P=0.598N     P=0.423N     P=0.472N    |P=0.087N     P=0.198      P=0.135N     P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.361N     P=0.574N     P=0.421N     P=0.491N    |P=0.067N     P=0.200      P=0.078N     P=0.286N     | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.651N     P=0.490N     P=0.500N    |P=0.077N     P=0.233      P=0.125N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/49 (22%)  3/50 (6%)    4/50 (8%)    13/49 (27%) |5/50 (10%)   2/49 (4%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     11/41.44     3/43.95      4/44.95      13/44.41    |5/44.29      2/42.13      3/43.86      2/43.85      | 
|POLY-3 PERCENT (g) |     26.5%        6.8%         8.9%         29.3%       |11.3%        4.8%         6.8%         4.6%         | 
|TERMINAL (d)       |     2/20 (10%)   0/29 (0%)    0/26 (0%)    1/27 (4%)   |3/33 (9%)    0/24 (0%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     589          353          528          332         |638          612          139          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207      P=0.011N*    P=0.022N*    P=0.539     |P=0.227N     P=0.304N     P=0.399N     P=0.247N     | 
|POLY 3             |     P=0.157      P=0.013N*    P=0.027N*    P=0.484     |P=0.206N     P=0.236N     P=0.361N     P=0.220N     | 
|POLY 1.5           |     P=0.152      P=0.015N*    P=0.033N*    P=0.448     |P=0.208N     P=0.229N     P=0.360N     P=0.217N     | 
|POLY 6             |     P=0.167      P=0.010N*    P=0.022N*    P=0.543     |P=0.206N     P=0.251N     P=0.369N     P=0.226N     | 
|LOGISTIC REGRESSION|     P=0.151      P=0.021N*    P=0.053N     P=0.407     |P=0.194N     P=0.225N     P=0.345N     P=0.211N     | 
|COCH-ARM / FISHERS |     P=0.149      P=0.018N*    P=0.041N*    P=0.407     |P=0.210N     P=0.226N     P=0.369N     P=0.218N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    20/50 (40%)  17/50 (34%)  28/49 (57%) |8/50 (16%)   26/49 (53%)  27/49 (55%)  37/50 (74%)  | 
|POLY-3 RATE (b)    |     3/39.18      20/44.25     17/45.84     28/44.29    |8/44.84      26/45.50     27/45.88     37/46.34     | 
|POLY-3 PERCENT (g) |     7.7%         45.2%        37.1%        63.2%       |17.8%        57.1%        58.9%        79.8%        | 
|TERMINAL (d)       |     3/20 (15%)   15/29 (52%)  7/26 (27%)   15/27 (56%) |5/33 (15%)   13/24 (54%)  15/29 (52%)  26/30 (87%)  | 
|FIRST INCIDENCE    |     729 (T)      485          633          390         |234          408          139          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P=0.008 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P=0.002 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Respiratory Epithelium, Epiglottis                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    22/50 (44%)  23/50 (46%)  33/49 (67%) |2/50 (4%)    33/49 (67%)  26/49 (53%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     0/39.18      22/42.93     23/45.58     33/45.15    |2/44.35      33/45.30     26/43.88     40/48.75     | 
|POLY-3 PERCENT (g) |     0.0%         51.2%        50.5%        73.1%       |4.5%         72.9%        59.3%        82.1%        | 
|TERMINAL (d)       |     0/20 (0%)    18/29 (62%)  15/26 (58%)  22/27 (82%) |1/33 (3%)    16/24 (67%)  20/29 (69%)  24/30 (80%)  | 
|FIRST INCIDENCE    |     ---          694          519          332         |519          533          572          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Respiratory Epithelium, Epiglottis                                                                                       | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    18/50 (36%)  34/50 (68%)  32/49 (65%) |0/50 (0%)    25/49 (51%)  26/49 (53%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     0/39.18      18/45.83     34/49.21     32/46.03    |0/43.71      25/45.25     26/45.42     33/47.79     | 
|POLY-3 PERCENT (g) |     0.0%         39.3%        69.1%        69.5%       |0.0%         55.3%        57.2%        69.1%        | 
|TERMINAL (d)       |     0/20 (0%)    7/29 (24%)   14/26 (54%)  16/27 (59%) |0/33 (0%)    10/24 (42%)  15/29 (52%)  18/30 (60%)  | 
|FIRST INCIDENCE    |     ---          311          392          533         |---          540          139          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Respiratory Epithelium, Epiglottis                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    9/50 (18%)   16/50 (32%)  19/49 (39%) |2/50 (4%)    7/49 (14%)   7/49 (14%)   16/50 (32%)  | 
|POLY-3 RATE (b)    |     0/39.18      9/44.99      16/47.38     19/43.84    |2/43.71      7/43.08      7/43.87      16/44.48     | 
|POLY-3 PERCENT (g) |     0.0%         20.0%        33.8%        43.3%       |4.6%         16.3%        16.0%        36.0%        | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    3/26 (12%)   7/27 (26%)  |2/33 (6%)    2/24 (8%)    2/29 (7%)    11/30 (37%)  | 
|FIRST INCIDENCE    |     ---          311          528          558         |731 (T)      540          139          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.047 *    P=0.068      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.074      P=0.079      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.076      P=0.078      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.071      P=0.078      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.077      P=0.079      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.075      P=0.075      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      0/40.96     |1/44.08      1/41.70      0/42.55      2/42.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         2.4%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |625          731 (T)      ---          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.363      P=0.714      P=0.509N     P=0.478      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.363      P=0.748      P=0.507N     P=0.489      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.365      P=0.755      P=0.504N     P=0.495      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.360      P=0.738      P=0.512N     P=0.482      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.366      P=0.761N     P=0.489N     P=0.502      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366      P=0.753N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      1/42.57      0/42.93      1/40.96     |2/43.71      2/42.08      2/43.20      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         2.4%        |4.6%         4.8%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    1/27 (4%)   |2/33 (6%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |731 (T)      667          570          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443      P=0.574      (e)          P=0.560     |P=0.177N     P=0.625      P=0.664      P=0.259N     | 
|POLY 3             |     P=0.415      P=0.513      (e)          P=0.506     |P=0.168N     P=0.681      P=0.690      P=0.243N     | 
|POLY 1.5           |     P=0.409      P=0.506      (e)          P=0.502     |P=0.166N     P=0.687      P=0.691      P=0.240N     | 
|POLY 6             |     P=0.427      P=0.527      (e)          P=0.514     |P=0.171N     P=0.670      P=0.688      P=0.248N     | 
|LOGISTIC REGRESSION|     (e)          P=0.574      (e)          P=0.560     |P=0.163N     P=0.679      P=0.695N     (e)          | 
|COCH-ARM / FISHERS |     P=0.405      P=0.500      (e)          P=0.500     |P=0.163N     P=0.691N     P=0.691N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/49 (2%)    7/50 (14%)  |1/50 (2%)    4/50 (8%)    9/50 (18%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/39.84      2/42.65      1/43.06      7/40.96     |1/44.04      4/41.94      9/42.62      5/42.83      | 
|POLY-3 PERCENT (g) |     7.5%         4.7%         2.3%         17.1%       |2.3%         9.5%         21.1%        11.7%        | 
|TERMINAL (d)       |     3/20 (15%)   1/29 (3%)    0/26 (0%)    7/27 (26%)  |0/33 (0%)    3/24 (13%)   8/29 (28%)   4/30 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      709          694          729 (T)     |638          668          712          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.081      P=0.330N     P=0.213N     P=0.295     |P=0.102      P=0.124      P=0.006 **   P=0.088      | 
|POLY 3             |     P=0.053      P=0.469N     P=0.277N     P=0.165     |P=0.090      P=0.163      P=0.006 **   P=0.094      | 
|POLY 1.5           |     P=0.053      P=0.487N     P=0.294N     P=0.160     |P=0.095      P=0.171      P=0.007 **   P=0.098      | 
|POLY 6             |     P=0.052      P=0.435N     P=0.252N     P=0.181     |P=0.083      P=0.152      P=0.005 **   P=0.089      | 
|LOGISTIC REGRESSION|     P=0.067      P=0.348N     P=0.210N     P=0.295     |P=0.094      P=0.170      P=0.007 **   P=0.099      | 
|COCH-ARM / FISHERS |     P=0.055      P=0.500N     P=0.316N     P=0.159     |P=0.103      P=0.181      P=0.008 **   P=0.102      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   7/49 (14%)   14/50 (28%) |9/50 (18%)   9/50 (18%)   10/50 (20%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     5/41.10      8/43.56      7/43.50      14/43.44    |9/45.46      9/43.15      10/43.59     13/44.03     | 
|POLY-3 PERCENT (g) |     12.2%        18.4%        16.1%        32.2%       |19.8%        20.9%        22.9%        29.5%        | 
|TERMINAL (d)       |     1/20 (5%)    5/29 (17%)   4/26 (15%)   7/27 (26%)  |5/33 (15%)   4/24 (17%)   8/29 (28%)   9/30 (30%)   | 
|FIRST INCIDENCE    |     477          571          655          542         |458          571          570          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.467      P=0.558      P=0.063     |P=0.166      P=0.411      P=0.408      P=0.185      | 
|POLY 3             |     P=0.014 *    P=0.312      P=0.419      P=0.022 *   |P=0.147      P=0.556      P=0.459      P=0.204      | 
|POLY 1.5           |     P=0.013 *    P=0.290      P=0.393      P=0.020 *   |P=0.155      P=0.578      P=0.474      P=0.219      | 
|POLY 6             |     P=0.017 *    P=0.358      P=0.464      P=0.031 *   |P=0.136      P=0.525      P=0.438      P=0.187      | 
|LOGISTIC REGRESSION|     P=0.013 *    P=0.278      P=0.374      P=0.021 *   |P=0.163      P=0.595N     P=0.500      P=0.235      | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.277      P=0.365      P=0.020 *   |P=0.164      P=0.602N     P=0.500      P=0.235      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      2/41.50     |0/43.71      1/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.8%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    1/27 (4%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          561         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.048 *    (e)          (e)          P=0.262     |P=0.568N     P=0.436      (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.246     |P=0.575N     P=0.491      (e)          (e)          | 
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.241     |P=0.571N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.047 *    (e)          (e)          P=0.257     |P=0.581N     P=0.483      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.049 *    (e)          (e)          P=0.238     |(e)          P=0.436      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.247     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    8/49 (16%)   5/50 (10%)  |6/50 (12%)   8/50 (16%)   5/50 (10%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     5/40.65      4/43.36      8/44.45      5/42.96     |6/44.03      8/43.31      5/44.86      7/43.92      | 
|POLY-3 PERCENT (g) |     12.3%        9.2%         18.0%        11.6%       |13.6%        18.5%        11.2%        15.9%        | 
|TERMINAL (d)       |     1/20 (5%)    1/29 (3%)    1/26 (4%)    1/27 (4%)   |3/33 (9%)    4/24 (17%)   0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     624          608          551          332         |666          499          421          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.532      P=0.349N     P=0.477      P=0.547N    |P=0.510      P=0.240      P=0.547N     P=0.441      | 
|POLY 3             |     P=0.500      P=0.459N     P=0.335      P=0.596N    |P=0.532      P=0.373      P=0.487N     P=0.498      | 
|POLY 1.5           |     P=0.487      P=0.482N     P=0.301      P=0.612N    |P=0.532      P=0.382      P=0.493N     P=0.501      | 
|POLY 6             |     P=0.520      P=0.418N     P=0.391      P=0.566N    |P=0.531      P=0.354      P=0.482N     P=0.492      | 
|LOGISTIC REGRESSION|     P=0.467      P=0.492N     P=0.259      P=0.628N    |P=0.533      P=0.381      P=0.483N     P=0.497      | 
|COCH-ARM / FISHERS |     P=0.468      P=0.500N     P=0.264      P=0.630N    |P=0.528      P=0.387      P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  8/50 (16%)   8/49 (16%)   14/50 (28%) |1/50 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     11/40.83     8/43.75      8/43.32      14/41.91    |1/43.71      2/41.99      1/43.02      1/42.54      | 
|POLY-3 PERCENT (g) |     26.9%        18.3%        18.5%        33.4%       |2.3%         4.8%         2.3%         2.4%         | 
|TERMINAL (d)       |     6/20 (30%)   4/29 (14%)   4/26 (15%)   11/27 (41%) |1/33 (3%)    1/24 (4%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     617          571          680          561         |731 (T)      652          589          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326      P=0.113N     P=0.125N     P=0.584N    |P=0.534N     P=0.424      P=0.744      P=0.741      | 
|POLY 3             |     P=0.189      P=0.243N     P=0.250N     P=0.342     |P=0.538N     P=0.486      P=0.757      P=0.755      | 
|POLY 1.5           |     P=0.190      P=0.276N     P=0.283N     P=0.328     |P=0.534N     P=0.493      P=0.758      P=0.758      | 
|POLY 6             |     P=0.188      P=0.189N     P=0.203N     P=0.378     |P=0.543N     P=0.475      P=0.755      P=0.750      | 
|LOGISTIC REGRESSION|     P=0.207      P=0.243N     P=0.171N     P=0.402     |P=0.531N     P=0.485      P=0.758N     P=0.741      | 
|COCH-ARM / FISHERS |     P=0.194      P=0.306N     P=0.323N     P=0.322     |P=0.531N     P=0.500      P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      3/44.35      2/44.19      0/40.96     |0/43.71      0/41.70      0/42.55      1/43.07      | 
|POLY-3 PERCENT (g) |     0.0%         6.8%         4.5%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          493          519          ---         |---          ---          ---          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413N     P=0.120      P=0.247      (e)         |P=0.202      (e)          (e)          P=0.504      | 
|POLY 3             |     P=0.389N     P=0.139      P=0.261      (e)         |P=0.199      (e)          (e)          P=0.497      | 
|POLY 1.5           |     P=0.401N     P=0.128      P=0.248      (e)         |P=0.199      (e)          (e)          P=0.499      | 
|POLY 6             |     P=0.365N     P=0.158      P=0.282      (e)         |P=0.199      (e)          (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.383N     P=0.134      P=0.152      (e)         |P=0.191      (e)          (e)          P=0.487      | 
|COCH-ARM / FISHERS |     P=0.410N     P=0.121      P=0.242      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/49 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.23      1/43.05      2/43.27      0/40.96     |1/44.04      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         2.3%         4.6%         0.0%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     619          584          671          ---         |638          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.355N     P=0.757N     P=0.597      P=0.495N    |P=0.312N     P=0.519N     P=0.505N     P=0.514N     | 
|POLY 3             |     P=0.367N     P=0.746N     P=0.525      P=0.496N    |P=0.299N     P=0.511N     P=0.507N     P=0.507N     | 
|POLY 1.5           |     P=0.369N     P=0.754N     P=0.510      P=0.499N    |P=0.303N     P=0.505N     P=0.504N     P=0.503N     | 
|POLY 6             |     P=0.363N     P=0.729N     P=0.550      P=0.490N    |P=0.294N     P=0.520N     P=0.511N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.368N     P=0.759N     P=0.470      P=0.494N    |P=0.303N     P=0.498N     P=0.491N     P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.367N     P=0.753N     P=0.492      P=0.500N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    1/49 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/40.08      0/42.57      1/43.10      4/40.96     |0/43.71      0/41.70      0/42.55      1/42.95      | 
|POLY-3 PERCENT (g) |     10.0%        0.0%         2.3%         9.8%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     3/20 (15%)   0/29 (0%)    0/26 (0%)    4/27 (15%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          ---          684          729 (T)     |---          ---          ---          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.459      P=0.030N*    P=0.111N     P=0.489N    |P=0.198      (e)          (e)          P=0.491      | 
|POLY 3             |     P=0.378      P=0.052N     P=0.156N     P=0.633N    |P=0.199      (e)          (e)          P=0.497      | 
|POLY 1.5           |     P=0.382      P=0.057N     P=0.170N     P=0.640N    |P=0.199      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.369      P=0.045N*    P=0.137N     P=0.613N    |P=0.199      (e)          (e)          P=0.494      | 
|LOGISTIC REGRESSION|     P=0.415      P=0.038N*    P=0.133N     P=0.540N    |P=0.195      (e)          (e)          P=0.497      | 
|COCH-ARM / FISHERS |     P=0.386      P=0.059N     P=0.187N     P=0.643N    |P=0.198      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      3/41.21     |0/43.71      2/41.99      0/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.3%        |0.0%         4.8%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    2/27 (7%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          661         |---          652          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.013 *    (e)          (e)          P=0.166     |P=0.532      P=0.202      (e)          P=0.481      | 
|POLY 3             |     P=0.011 *    (e)          (e)          P=0.124     |P=0.527      P=0.228      (e)          P=0.495      | 
|POLY 1.5           |     P=0.011 *    (e)          (e)          P=0.121     |P=0.533      P=0.233      (e)          P=0.497      | 
|POLY 6             |     P=0.011 *    (e)          (e)          P=0.132     |P=0.518      P=0.221      (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.011 *    (e)          (e)          P=0.133     |P=0.536      P=0.234      (e)          P=0.481      | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.539      P=0.247      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/49 (2%)    2/48 (4%)    1/50 (2%)   |1/49 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/40.54      1/42.85      2/42.77      1/41.34     |1/43.71      1/41.17      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     12.3%        2.3%         4.7%         2.4%        |2.3%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/20 (10%)   0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     638          548          729 (T)      623         |666          633          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.073N     P=0.060N     P=0.126N     P=0.074N    |P=0.244N     P=0.747      P=0.510N     P=0.516N     | 
|POLY 3             |     P=0.095N     P=0.088N     P=0.193N     P=0.095N    |P=0.237N     P=0.747      P=0.505N     P=0.505N     | 
|POLY 1.5           |     P=0.094N     P=0.097N     P=0.210N     P=0.099N    |P=0.235N     P=0.754      P=0.502N     P=0.501N     | 
|POLY 6             |     P=0.097N     P=0.074N     P=0.171N     P=0.087N    |P=0.239N     P=0.738      P=0.510N     P=0.511N     | 
|LOGISTIC REGRESSION|     P=0.094N     P=0.111N     P=0.172N     P=0.101N    |P=0.228N     P=0.755N     P=0.490N     P=0.492N     | 
|COCH-ARM / FISHERS |     P=0.093N     P=0.107N     P=0.235N     P=0.102N    |P=0.232N     P=0.753N     P=0.495N     P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/48 (0%)    0/50 (0%)   |2/49 (4%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/43.38      0/42.77      0/40.96     |2/43.52      0/40.82      0/42.55      1/43.30      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |4.6%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          311          ---          ---         |717          ---          ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389N     P=0.278      (e)          (e)         |P=0.469N     P=0.304N     P=0.275N     P=0.525N     | 
|POLY 3             |     P=0.378N     P=0.256      (e)          (e)         |P=0.447N     P=0.251N     P=0.242N     P=0.502N     | 
|POLY 1.5           |     P=0.391N     P=0.245      (e)          (e)         |P=0.451N     P=0.245N     P=0.239N     P=0.497N     | 
|POLY 6             |     P=0.356N     P=0.277      (e)          (e)         |P=0.441N     P=0.261N     P=0.247N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.383N     P=0.273      (e)          (e)         |P=0.449N     P=0.271N     P=0.251N     P=0.483N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.242      (e)          (e)         |P=0.455N     P=0.247N     P=0.242N     P=0.492N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   8/49 (16%)   24/48 (50%)  42/50 (84%) |10/49 (20%)  10/49 (20%)  14/50 (28%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     5/40.60      8/42.77      24/46.03     42/48.74    |10/43.51     10/41.35     14/43.57     40/47.41     | 
|POLY-3 PERCENT (g) |     12.3%        18.7%        52.1%        86.2%       |23.0%        24.2%        32.1%        84.4%        | 
|TERMINAL (d)       |     1/20 (5%)    6/29 (21%)   12/26 (46%)  24/27 (89%) |9/33 (27%)   7/24 (29%)   9/29 (31%)   25/30 (83%)  | 
|FIRST INCIDENCE    |     666          652          519          332         |720          667          589          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.516      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.320      P=0.154      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.308      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.550      P=0.236      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.283      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.573      P=0.242      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.354      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.520      P=0.231      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.340      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.452      P=0.200      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.264      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.599N     P=0.259      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/48 (0%)    1/50 (2%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.27      0/42.77      1/41.81     |0/43.46      0/40.82      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    2/29 (7%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          390         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.572      P=0.323      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.564      P=0.250      (e)          P=0.510     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.552      P=0.241      (e)          P=0.505     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.586      P=0.268      (e)          P=0.519     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.544      P=0.323      (e)          P=0.662     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.242      (e)          P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   24/49 (49%)  34/48 (71%)  49/50 (98%) |4/49 (8%)    8/49 (16%)   21/50 (42%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     7/40.77      24/44.08     34/45.04     49/50.00    |4/43.46      8/42.12      21/44.45     50/50.00     | 
|POLY-3 PERCENT (g) |     17.2%        54.5%        75.5%        98.0%       |9.2%         19.0%        47.3%        100.0%       | 
|TERMINAL (d)       |     3/20 (15%)   16/29 (55%)  22/26 (85%)  26/27 (96%) |4/33 (12%)   3/24 (13%)   13/29 (45%)  30/30 (100%) | 
|FIRST INCIDENCE    |     628          571          584          332         |731 (T)      540          589          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.092      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.159      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.168      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.160      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.178      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/48 (0%)    21/50 (42%) |0/49 (0%)    0/49 (0%)    0/50 (0%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/40.08      0/42.27      0/42.77      21/43.59    |0/43.46      0/40.82      0/42.55      6/44.00      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         48.2%       |0.0%         0.0%         0.0%         13.6%        | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    12/27 (44%) |0/33 (0%)    0/24 (0%)    0/29 (0%)    3/30 (10%)   | 
|FIRST INCIDENCE    |     666          ---          ---          390         |---          ---          ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.461N     P=0.461N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.016 *    | 
|POLY 3             |     P<0.001 **   P=0.489N     P=0.487N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.016 *    | 
|POLY 1.5           |     P<0.001 **   P=0.497N     P=0.496N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.016 *    | 
|POLY 6             |     P<0.001 **   P=0.475N     P=0.473N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.015 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.507N     P=0.530N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.020 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.505N     P=0.510N     P<0.001 **  |P<0.001 **   (e)          (e)          P=0.014 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  40/49 (82%)  45/48 (94%)  50/50 (100%)|26/49 (53%)  35/49 (71%)  44/50 (88%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     22/43.57     40/46.79     45/47.73     50/50.00    |26/44.80     35/43.91     44/46.83     50/50.00     | 
|POLY-3 PERCENT (g) |     50.5%        85.5%        94.3%        100.0%      |58.0%        79.7%        94.0%        100.0%       | 
|TERMINAL (d)       |     9/20 (45%)   25/29 (86%)  24/26 (92%)  27/27 (100%)|20/33 (61%)  21/24 (88%)  28/29 (97%)  30/30 (100%) | 
|FIRST INCIDENCE    |     502          353          519          332         |548          540          421          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.101      P=0.020 *    P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.027 *    P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.047 *    P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    2/48 (4%)    28/50 (56%) |1/49 (2%)    1/49 (2%)    8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/40.17      0/42.27      2/43.60      28/44.35    |1/43.46      1/41.34      8/43.02      7/43.81      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         4.6%         63.1%       |2.3%         2.4%         18.6%        16.0%        | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    20/27 (74%) |1/33 (3%)    0/24 (0%)    7/29 (24%)   3/30 (10%)   | 
|FIRST INCIDENCE    |     638          ---          584          533         |731 (T)      571          589          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.468N     P=0.549      P<0.001 **  |P=0.009 **   P=0.725      P=0.011 *    P=0.029 *    | 
|POLY 3             |     P<0.001 **   P=0.490N     P=0.529      P<0.001 **  |P=0.007 **   P=0.750      P=0.014 *    P=0.030 *    | 
|POLY 1.5           |     P<0.001 **   P=0.498N     P=0.510      P<0.001 **  |P=0.007 **   P=0.755      P=0.015 *    P=0.031 *    | 
|POLY 6             |     P<0.001 **   P=0.476N     P=0.556      P<0.001 **  |P=0.007 **   P=0.742      P=0.013 *    P=0.030 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.510N     P=0.348      P<0.001 **  |P=0.008 **   P=0.755N     P=0.015 *    P=0.035 *    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.505N     P=0.485      P<0.001 **  |P=0.008 **   P=0.753N     P=0.017 *    P=0.032 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    17/49 (35%)  31/48 (65%)  49/50 (98%) |6/49 (12%)   5/49 (10%)   14/50 (28%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     3/40.20      17/43.02     31/44.40     49/49.68    |6/44.49      5/41.47      14/43.15     48/50.00     | 
|POLY-3 PERCENT (g) |     7.5%         39.5%        69.8%        98.6%       |13.5%        12.1%        32.5%        96.0%        | 
|TERMINAL (d)       |     2/20 (10%)   13/29 (45%)  20/26 (77%)  27/27 (100%)|4/33 (12%)   3/24 (13%)   10/29 (35%)  28/30 (93%)  | 
|FIRST INCIDENCE    |     628          652          633          332         |234          540          661          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.581      P=0.024 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.549N     P=0.029 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.530N     P=0.032 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.574N     P=0.026 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.479N     P=0.040 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500N     P=0.044 *    P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/48 (0%)    7/50 (14%)  |0/49 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.27      0/42.77      7/41.72     |0/43.46      0/40.82      0/42.55      1/43.30      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         16.8%       |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    3/27 (11%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          642         |---          ---          ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.025 *   |P=0.199      (e)          (e)          P=0.500      | 
|POLY 3             |     P<0.001 **   (e)          (e)          P=0.009 **  |P=0.201      (e)          (e)          P=0.499      | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.008 **  |P=0.202      (e)          (e)          P=0.502      | 
|POLY 6             |     P<0.001 **   (e)          (e)          P=0.010 *   |P=0.201      (e)          (e)          P=0.496      | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          (e)          P=0.011 *   |P=0.176      (e)          (e)          P=0.460      | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          (e)          P=0.006 **  |P=0.201      (e)          (e)          P=0.505      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   7/49 (14%)   16/48 (33%)  38/50 (76%) |19/49 (39%)  7/49 (14%)   12/50 (24%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     7/41.02      7/42.68      16/44.30     38/45.78    |19/45.12     7/41.77      12/44.31     32/45.63     | 
|POLY-3 PERCENT (g) |     17.1%        16.4%        36.1%        83.0%       |42.1%        16.8%        27.1%        70.1%        | 
|TERMINAL (d)       |     2/20 (10%)   5/29 (17%)   7/26 (27%)   24/27 (89%) |14/33 (42%)  3/24 (13%)   5/29 (17%)   22/30 (73%)  | 
|FIRST INCIDENCE    |     624          673          528          332         |463          540          421          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.363N     P=0.152      P<0.001 **  |P<0.001 **   P=0.044N*    P=0.191N     P=0.005 **   | 
|POLY 3             |     P<0.001 **   P=0.584N     P=0.038 *    P<0.001 **  |P<0.001 **   P=0.008N**   P=0.099N     P=0.004 **   | 
|POLY 1.5           |     P<0.001 **   P=0.609N     P=0.029 *    P<0.001 **  |P<0.001 **   P=0.006N**   P=0.094N     P=0.006 **   | 
|POLY 6             |     P<0.001 **   P=0.538N     P=0.055      P<0.001 **  |P<0.001 **   P=0.010N*    P=0.104N     P=0.003 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.561N     P=0.035 *    P<0.001 **  |P<0.001 **   P=0.007N**   P=0.092N     P=0.007 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.597      P=0.021 *    P<0.001 **  |P<0.001 **   P=0.006N**   P=0.085N     P=0.010 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/39 (21%)   8/44 (18%)   3/47 (6%)    12/44 (27%) |16/42 (38%)  6/45 (13%)   8/44 (18%)   5/44 (11%)   | 
|POLY-3 RATE (b)    |     8/32.34      8/38.55      3/40.96      12/37.60    |16/38.87     6/38.95      8/38.17      5/38.21      | 
|POLY-3 PERCENT (g) |     24.7%        20.8%        7.3%         31.9%       |41.2%        15.4%        21.0%        13.1%        | 
|TERMINAL (d)       |     7/17 (41%)   7/27 (26%)   2/24 (8%)    10/25 (40%) |14/29 (48%)  3/22 (14%)   7/27 (26%)   3/28 (11%)   | 
|FIRST INCIDENCE    |     708          608          722          558         |458          408          589          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.328      P=0.241N     P=0.024N*    P=0.540     |P=0.010N*    P=0.051N     P=0.062N     P=0.008N**   | 
|POLY 3             |     P=0.243      P=0.455N     P=0.038N*    P=0.344     |P=0.007N**   P=0.009N**   P=0.044N*    P=0.004N**   | 
|POLY 1.5           |     P=0.243      P=0.483N     P=0.043N*    P=0.330     |P=0.007N**   P=0.008N**   P=0.041N*    P=0.004N**   | 
|POLY 6             |     P=0.247      P=0.399N     P=0.029N*    P=0.380     |P=0.007N**   P=0.011N*    P=0.048N*    P=0.005N**   | 
|LOGISTIC REGRESSION|     P=0.252      P=0.319N     P=0.014N*    P=0.390     |P=0.009N**   P=0.008N**   P=0.044N*    P=0.005N**   | 
|COCH-ARM / FISHERS |     P=0.246      P=0.503N     P=0.051N     P=0.323     |P=0.008N**   P=0.008N**   P=0.034N*    P=0.004N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/47 (0%)    0/46 (0%)    2/44 (5%)   |0/48 (0%)    0/50 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/36.59      0/40.55      0/41.44      2/37.46     |0/42.33      0/41.70      0/42.55      0/40.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         5.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/19 (0%)    0/28 (0%)    0/26 (0%)    0/25 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/29 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          542         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.042 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.256     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.057      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/45 (38%)  15/47 (32%)  17/46 (37%)  17/44 (39%) |26/48 (54%)  14/50 (28%)  20/50 (40%)  24/48 (50%)  | 
|POLY-3 RATE (b)    |     17/38.78     15/41.09     17/42.09     17/37.41    |26/45.00     14/44.38     20/44.02     24/43.87     | 
|POLY-3 PERCENT (g) |     43.8%        36.5%        40.4%        45.4%       |57.8%        31.5%        45.4%        54.7%        | 
|TERMINAL (d)       |     8/19 (42%)   11/28 (39%)  11/26 (42%)  13/25 (52%) |19/33 (58%)  6/24 (25%)   17/29 (59%)  15/29 (52%)  | 
|FIRST INCIDENCE    |     617          677          655          661         |463          408          139          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.399N     P=0.096N     P=0.207N     P=0.293N    |P=0.360      P=0.117N     P=0.311N     P=0.528      | 
|POLY 3             |     P=0.405      P=0.327N     P=0.464N     P=0.537     |P=0.386      P=0.009N**   P=0.165N     P=0.469N     | 
|POLY 1.5           |     P=0.406      P=0.346N     P=0.507N     P=0.534     |P=0.395      P=0.007N**   P=0.134N     P=0.441N     | 
|POLY 6             |     P=0.419      P=0.288N     P=0.398N     P=0.564     |P=0.375      P=0.013N*    P=0.225N     P=0.508N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.220N     P=0.328N     P=0.536N    |P=0.396      P=0.008N**   P=0.126N     P=0.437N     | 
|COCH-ARM / FISHERS |     P=0.426      P=0.355N     P=0.554N     P=0.553     |P=0.406      P=0.007N**   P=0.115N     P=0.419N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/50 (2%)    5/49 (10%)   4/50 (8%)   |5/50 (10%)   2/50 (4%)    4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/39.15      1/42.63      5/43.81      4/41.13     |5/43.71      2/41.70      4/42.67      6/42.99      | 
|POLY-3 PERCENT (g) |     5.1%         2.4%         11.4%        9.7%        |11.4%        4.8%         9.4%         14.0%        | 
|TERMINAL (d)       |     0/19 (0%)    0/29 (0%)    1/26 (4%)    3/27 (11%)  |5/33 (15%)   2/24 (8%)    3/29 (10%)   4/30 (13%)   | 
|FIRST INCIDENCE    |     666          714          653          685         |731 (T)      731 (T)      698          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203      P=0.389N     P=0.359      P=0.459     |P=0.280      P=0.359N     P=0.578N     P=0.434      | 
|POLY 3             |     P=0.161      P=0.470N     P=0.263      P=0.359     |P=0.290      P=0.235N     P=0.515N     P=0.488      | 
|POLY 1.5           |     P=0.162      P=0.481N     P=0.244      P=0.354     |P=0.290      P=0.225N     P=0.510N     P=0.495      | 
|POLY 6             |     P=0.164      P=0.448N     P=0.300      P=0.376     |P=0.291      P=0.250N     P=0.523N     P=0.480      | 
|LOGISTIC REGRESSION|     P=0.165      P=0.480N     P=0.218      P=0.380     |P=0.270      P=0.359N     P=0.556N     P=0.463      | 
|COCH-ARM / FISHERS |     P=0.167      P=0.485N     P=0.226      P=0.359     |P=0.289      P=0.218N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland: Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/38.71      0/42.57      0/42.93      0/40.96     |3/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.9%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/19 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |3/33 (9%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.053N     P=0.182N     P=0.144N     P=0.138N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.043N*    P=0.127N     P=0.123N     P=0.123N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044N*    P=0.123N     P=0.122N     P=0.121N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.041N*    P=0.134N     P=0.126N     P=0.127N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.053N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.047N*    P=0.121N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/8 (88%)    16/18 (89%)  9/12 (75%)   8/9 (89%)   |9/9 (100%)   20/20 (100%) 17/22 (77%)  15/15 (100%) | 
|POLY-3 RATE (b)    |     7/7.86       16/16.39     9/11.86      8/8.83      |9/9.00       20/20.00     17/20.26     15/15.00     | 
|POLY-3 PERCENT (g) |     89.0%        97.6%        75.9%        90.6%       |100.0%       100.0%       83.9%        100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   12/12 (100%) 3/4 (75%)    5/5 (100%)  |6/6 (100%)   9/9 (100%)   8/9 (89%)    11/11 (100%) | 
|FIRST INCIDENCE    |     589          584          584          623         |638          408          421          440          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210N     P=0.274N     P=0.401N     P=0.215N    |P=0.460N     (e)          P=0.109      (e)          | 
|POLY 3             |     P=0.489N     P=0.540      P=0.443N     P=0.762     |P=0.620N     (e)          P=0.240N     (e)          | 
|POLY 1.5           |     P=0.513N     P=0.603      P=0.450N     P=0.748     |P=0.601N     (e)          P=0.212N     (e)          | 
|POLY 6             |     P=0.484N     P=0.535      P=0.432N     P=0.795     |P=0.653N     (e)          P=0.288N     (e)          | 
|LOGISTIC REGRESSION|     P=0.439N     P=0.644      P=0.742N     P=0.716     |P=0.578N     (e)          P=0.225N     (e)          | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.686      P=0.465N     P=0.735     |P=0.555N     (e)          P=0.155N     (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    5/50 (10%)   1/49 (2%)    1/48 (2%)   |3/50 (6%)    4/50 (8%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/39.80      5/42.90      1/42.93      1/40.02     |3/43.95      4/41.82      1/42.94      2/42.77      | 
|POLY-3 PERCENT (g) |     7.5%         11.7%        2.3%         2.5%        |6.8%         9.6%         2.3%         4.7%         | 
|TERMINAL (d)       |     1/20 (5%)    2/29 (7%)    1/26 (4%)    0/27 (0%)   |2/33 (6%)    3/24 (13%)   0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     617          677          729 (T)      631         |666          701          617          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.086N     P=0.527      P=0.240N     P=0.277N    |P=0.308N     P=0.364      P=0.340N     P=0.535N     | 
|POLY 3             |     P=0.109N     P=0.398      P=0.278N     P=0.302N    |P=0.299N     P=0.473      P=0.313N     P=0.512N     | 
|POLY 1.5           |     P=0.114N     P=0.380      P=0.290N     P=0.309N    |P=0.296N     P=0.487      P=0.311N     P=0.506N     | 
|POLY 6             |     P=0.100N     P=0.433      P=0.259N     P=0.287N    |P=0.304N     P=0.451      P=0.318N     P=0.522N     | 
|LOGISTIC REGRESSION|     P=0.115N     P=0.394      P=0.305N     P=0.314N    |P=0.297N     P=0.449      P=0.306N     P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.119N     P=0.369      P=0.309N     P=0.316N    |P=0.292N     P=0.500      P=0.309N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/49 (16%)   7/50 (14%)   3/49 (6%)    11/48 (23%) |3/50 (6%)    6/50 (12%)   5/50 (10%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     8/40.41      7/43.39      3/43.39      11/41.65    |3/43.95      6/42.20      5/44.01      10/44.60     | 
|POLY-3 PERCENT (g) |     19.8%        16.1%        6.9%         26.4%       |6.8%         14.2%        11.4%        22.4%        | 
|TERMINAL (d)       |     3/20 (15%)   3/29 (10%)   1/26 (4%)    4/27 (15%)  |2/33 (6%)    3/24 (13%)   1/29 (3%)    3/30 (10%)   | 
|FIRST INCIDENCE    |     617          584          633          542         |666          667          570          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.322      P=0.285N     P=0.050N     P=0.469     |P=0.034 *    P=0.157      P=0.324      P=0.035 *    | 
|POLY 3             |     P=0.233      P=0.440N     P=0.075N     P=0.326     |P=0.029 *    P=0.221      P=0.357      P=0.036 *    | 
|POLY 1.5           |     P=0.224      P=0.465N     P=0.086N     P=0.304     |P=0.028 *    P=0.232      P=0.356      P=0.036 *    | 
|POLY 6             |     P=0.248      P=0.394N     P=0.062N     P=0.374     |P=0.030 *    P=0.205      P=0.356      P=0.036 *    | 
|LOGISTIC REGRESSION|     P=0.220      P=0.453N     P=0.091N     P=0.294     |P=0.028 *    P=0.213      P=0.364      P=0.038 *    | 
|COCH-ARM / FISHERS |     P=0.218      P=0.483N     P=0.100N     P=0.287     |P=0.028 *    P=0.243      P=0.357      P=0.036 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell, Respiratory Epithelium                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    15/50 (30%)  12/49 (24%)  17/48 (35%) |13/50 (26%)  18/50 (36%)  16/50 (32%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     4/40.05      15/45.12     12/43.84     17/41.96    |13/44.80     18/43.25     16/44.70     30/45.75     | 
|POLY-3 PERCENT (g) |     10.0%        33.2%        27.4%        40.5%       |29.0%        41.6%        35.8%        65.6%        | 
|TERMINAL (d)       |     1/20 (5%)    4/29 (14%)   8/26 (31%)   10/27 (37%) |8/33 (24%)   10/24 (42%)  8/29 (28%)   20/30 (67%)  | 
|FIRST INCIDENCE    |     612          584          633          542         |625          571          570          589          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023 *    P=0.039 *    P=0.092      P=0.010 *   |P<0.001 **   P=0.064      P=0.251      P<0.001 **   | 
|POLY 3             |     P=0.006 **   P=0.008 **   P=0.037 *    P<0.001 **  |P<0.001 **   P=0.152      P=0.323      P<0.001 **   | 
|POLY 1.5           |     P=0.005 **   P=0.006 **   P=0.031 *    P<0.001 **  |P<0.001 **   P=0.172      P=0.322      P<0.001 **   | 
|POLY 6             |     P=0.009 **   P=0.015 *    P=0.050      P=0.002 **  |P<0.001 **   P=0.128      P=0.323      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.006 **   P=0.039 *    P<0.001 **  |P<0.001 **   P=0.147      P=0.311      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.005 **   P=0.027 *    P<0.001 **  |P<0.001 **   P=0.194      P=0.330      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/49 (0%)    0/48 (0%)   |2/50 (4%)    4/50 (8%)    2/50 (4%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/39.35      2/43.49      0/42.93      0/39.67     |2/43.71      4/42.23      2/42.94      7/43.09      | 
|POLY-3 PERCENT (g) |     2.5%         4.6%         0.0%         0.0%        |4.6%         9.5%         4.7%         16.3%        | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    2/24 (8%)    1/29 (3%)    5/30 (17%)   | 
|FIRST INCIDENCE    |     652          311          ---          ---         |731 (T)      652          617          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173N     P=0.567      P=0.447N     P=0.488N    |P=0.059      P=0.245      P=0.654      P=0.065      | 
|POLY 3             |     P=0.182N     P=0.535      P=0.483N     P=0.498N    |P=0.053      P=0.321      P=0.688      P=0.074      | 
|POLY 1.5           |     P=0.187N     P=0.521      P=0.491N     P=0.502N    |P=0.054      P=0.330      P=0.689      P=0.077      | 
|POLY 6             |     P=0.174N     P=0.558      P=0.470N     P=0.490N    |P=0.051      P=0.308      P=0.685      P=0.070      | 
|LOGISTIC REGRESSION|     P=0.186N     P=0.542      P=0.520N     P=0.505N    |P=0.054      P=0.313      P=0.689      P=0.072      | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.508      P=0.500N     P=0.505N    |P=0.056      P=0.339      P=0.691N     P=0.080      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   3/50 (6%)    1/49 (2%)    4/48 (8%)   |16/50 (32%)  20/50 (40%)  6/50 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     9/41.18      3/42.99      1/43.06      4/40.28     |16/44.97     20/43.64     6/43.52      4/43.58      | 
|POLY-3 PERCENT (g) |     21.9%        7.0%         2.3%         9.9%        |35.6%        45.8%        13.8%        9.2%         | 
|TERMINAL (d)       |     2/20 (10%)   2/29 (7%)    0/26 (0%)    3/27 (11%)  |11/33 (33%)  12/24 (50%)  4/29 (14%)   2/30 (7%)    | 
|FIRST INCIDENCE    |     502          608          694          533         |624          499          421          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.071N     P=0.031N*    P=0.005N**   P=0.076N    |P<0.001N**   P=0.078      P=0.034N*    P=0.008N**   | 
|POLY 3             |     P=0.092N     P=0.048N*    P=0.006N**   P=0.119N    |P<0.001N**   P=0.219      P=0.014N*    P=0.002N**   | 
|POLY 1.5           |     P=0.093N     P=0.052N     P=0.007N**   P=0.123N    |P<0.001N**   P=0.243      P=0.014N*    P=0.002N**   | 
|POLY 6             |     P=0.092N     P=0.040N*    P=0.005N**   P=0.110N    |P<0.001N**   P=0.184      P=0.017N*    P=0.003N**   | 
|LOGISTIC REGRESSION|     P=0.099N     P=0.059N     P=0.012N*    P=0.126N    |P<0.001N**   P=0.212      P=0.016N*    P=0.003N**   | 
|COCH-ARM / FISHERS |     P=0.098N     P=0.056N     P=0.008N**   P=0.124N    |P<0.001N**   P=0.266      P=0.014N*    P=0.003N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    1/49 (2%)    3/48 (6%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/39.46      1/43.05      1/43.05      3/40.44     |1/43.71      2/42.46      1/43.07      2/43.46      | 
|POLY-3 PERCENT (g) |     5.1%         2.3%         2.3%         7.4%        |2.3%         4.7%         2.3%         4.6%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    0/26 (0%)    1/27 (4%)   |1/33 (3%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     617          584          698          542         |731 (T)      571          570          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348      P=0.460N     P=0.421N     P=0.571     |P=0.442      P=0.464      P=0.749      P=0.484      | 
|POLY 3             |     P=0.319      P=0.470N     P=0.470N     P=0.511     |P=0.444      P=0.490      P=0.758      P=0.498      | 
|POLY 1.5           |     P=0.317      P=0.483N     P=0.484N     P=0.499     |P=0.445      P=0.495      P=0.758      P=0.500      | 
|POLY 6             |     P=0.324      P=0.446N     P=0.447N     P=0.536     |P=0.443      P=0.481      P=0.756      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.313      P=0.498N     P=0.497N     P=0.488     |P=0.445      P=0.506      P=0.756N     P=0.501      | 
|COCH-ARM / FISHERS |     P=0.314      P=0.492N     P=0.500N     P=0.490     |P=0.444      P=0.500      P=0.753N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    3/50 (6%)    1/49 (2%)    3/48 (6%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.07      3/43.44      1/43.05      3/40.51     |0/43.71      0/41.70      2/43.09      1/42.56      | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         2.3%         7.4%        |0.0%         0.0%         4.6%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          584          698          578         |---          ---          572          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175      P=0.164      P=0.567      P=0.143     |P=0.255      (e)          P=0.229      P=0.488      | 
|POLY 3             |     P=0.173      P=0.138      P=0.519      P=0.124     |P=0.241      (e)          P=0.234      P=0.495      | 
|POLY 1.5           |     P=0.164      P=0.129      P=0.510      P=0.119     |P=0.243      (e)          P=0.235      P=0.497      | 
|POLY 6             |     P=0.193      P=0.156      P=0.534      P=0.137     |P=0.237      (e)          P=0.232      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.157      P=0.121      P=0.520      P=0.116     |P=0.246      (e)          P=0.244      P=0.486      | 
|COCH-ARM / FISHERS |     P=0.156      P=0.125      P=0.500      P=0.117     |P=0.246      (e)          P=0.247      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    10/50 (20%)  7/50 (14%)   12/50 (24%)  | 
|POLY-3 RATE (b)    |                                                        |4/43.71      10/43.64     7/43.13      12/44.33     | 
|POLY-3 PERCENT (g) |                                                        |9.2%         22.9%        16.2%        27.1%        | 
|TERMINAL (d)       |                                                        |4/33 (12%)   5/24 (21%)   4/29 (14%)   8/30 (27%)   | 
|FIRST INCIDENCE    |                                                        |731 (T)      499          652          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.048 *    P=0.031 *    P=0.209      P=0.020 *    | 
|POLY 3             |                                                        |P=0.043 *    P=0.070      P=0.252      P=0.026 *    | 
|POLY 1.5           |                                                        |P=0.043 *    P=0.072      P=0.255      P=0.026 *    | 
|POLY 6             |                                                        |P=0.043 *    P=0.066      P=0.248      P=0.026 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.043 *    P=0.072      P=0.236      P=0.026 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.044 *    P=0.074      P=0.262      P=0.027 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Follicle                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/43.71      1/41.94      1/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |                                                        |4.6%         2.4%         2.4%         0.0%         | 
|TERMINAL (d)       |                                                        |2/33 (6%)    0/24 (0%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      667          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.162N     P=0.573N     P=0.545N     P=0.259N     | 
|POLY 3             |                                                        |P=0.155N     P=0.514N     P=0.509N     P=0.243N     | 
|POLY 1.5           |                                                        |P=0.154N     P=0.507N     P=0.506N     P=0.240N     | 
|POLY 6             |                                                        |P=0.156N     P=0.526N     P=0.515N     P=0.248N     | 
|LOGISTIC REGRESSION|                                                        |P=0.158N     P=0.521N     P=0.545N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    4/49 (8%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/40.26      0/42.57      4/43.87      1/40.96     |2/43.80      0/41.70      1/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     7.5%         0.0%         9.1%         2.4%        |4.6%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    1/26 (4%)    1/27 (4%)   |1/33 (3%)    0/24 (0%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     636          ---          633          729 (T)     |708          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.077N     P=0.631      P=0.235N    |P=0.201N     P=0.295N     P=0.547N     P=0.263N     | 
|POLY 3             |     P=0.411N     P=0.108N     P=0.547      P=0.298N    |P=0.186N     P=0.248N     P=0.512N     P=0.244N     | 
|POLY 1.5           |     P=0.408N     P=0.114N     P=0.520      P=0.303N    |P=0.187N     P=0.242N     P=0.510N     P=0.240N     | 
|POLY 6             |     P=0.415N     P=0.098N     P=0.590      P=0.286N    |P=0.184N     P=0.257N     P=0.517N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.404N     P=0.111N     P=0.480      P=0.284N    |P=0.196N     P=0.260N     P=0.522N     P=0.249N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.121N     P=0.489      P=0.309N    |P=0.189N     P=0.247N     P=0.508N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      3/40.96     |0/43.71      0/41.70      0/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    3/27 (11%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.014 *    (e)          (e)          P=0.177     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.011 *    (e)          (e)          P=0.123     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.011 *    (e)          (e)          P=0.120     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.011 *    (e)          (e)          P=0.130     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.177     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/42.93      2/41.13     |0/43.71      0/41.70      0/42.34      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          685         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.051      (e)          (e)          P=0.297     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.244     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.046 *    (e)          (e)          P=0.254     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.045 *    (e)          (e)          P=0.255     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |4/49 (8%)    3/50 (6%)    1/49 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      0/43.82      0/40.96     |4/43.83      3/42.27      1/42.86      3/43.70      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |9.1%         7.1%         2.3%         6.9%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |2/33 (6%)    1/24 (4%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |463          608          572          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.591N     P=0.203N     P=0.536N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.391N     P=0.520N     P=0.185N     P=0.502N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.505N     P=0.183N     P=0.495N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.393N     P=0.541N     P=0.190N     P=0.512N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.388N     P=0.480N     P=0.168N     P=0.488N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.489N     P=0.181N     P=0.489N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/40.21      1/43.14      0/43.82      1/41.87     |1/43.51      0/41.70      3/42.75      0/42.54      | 
|POLY-3 PERCENT (g) |     7.5%         2.3%         0.0%         2.4%        |2.3%         0.0%         7.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     650          548          ---          332         |458          ---          683          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.181N     P=0.231N     P=0.076N     P=0.253N    |P=0.518N     P=0.504N     P=0.285      P=0.508N     | 
|POLY 3             |     P=0.200N     P=0.280N     P=0.103N     P=0.290N    |P=0.503N     P=0.508N     P=0.299      P=0.504N     | 
|POLY 1.5           |     P=0.199N     P=0.294N     P=0.110N     P=0.298N    |P=0.500N     P=0.502N     P=0.301      P=0.501N     | 
|POLY 6             |     P=0.203N     P=0.256N     P=0.093N     P=0.276N    |P=0.507N     P=0.517N     P=0.295      P=0.510N     | 
|LOGISTIC REGRESSION|     P=0.195N     P=0.310N     P=0.102N     P=0.287N    |P=0.496N     P=0.568N     P=0.312      P=0.554N     | 
|COCH-ARM / FISHERS |     P=0.200N     P=0.309N     P=0.121N     P=0.309N    |P=0.496N     P=0.495N     P=0.309      P=0.495N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   5/50 (10%)   4/50 (8%)   |12/49 (24%)  6/50 (12%)   16/49 (33%)  4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/40.24      5/43.04      5/44.31      4/42.02     |12/44.86     6/42.35      16/44.13     4/42.99      | 
|POLY-3 PERCENT (g) |     5.0%         11.6%        11.3%        9.5%        |26.8%        14.2%        36.3%        9.3%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   4/26 (15%)   1/27 (4%)   |6/33 (18%)   4/24 (17%)   9/29 (31%)   3/30 (10%)   | 
|FIRST INCIDENCE    |     617          652          584          538         |463          540          570          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.433      P=0.353      P=0.305      P=0.410     |P=0.105N     P=0.230N     P=0.191      P=0.049N*    | 
|POLY 3             |     P=0.388      P=0.243      P=0.256      P=0.356     |P=0.082N     P=0.116N     P=0.230      P=0.030N*    | 
|POLY 1.5           |     P=0.374      P=0.228      P=0.238      P=0.345     |P=0.076N     P=0.101N     P=0.236      P=0.027N*    | 
|POLY 6             |     P=0.417      P=0.275      P=0.287      P=0.381     |P=0.091N     P=0.141N     P=0.221      P=0.036N*    | 
|LOGISTIC REGRESSION|     P=0.364      P=0.239      P=0.239      P=0.336     |P=0.076N     P=0.088N     P=0.250      P=0.025N*    | 
|COCH-ARM / FISHERS |     P=0.362      P=0.218      P=0.218      P=0.339     |P=0.075N     P=0.088N     P=0.251      P=0.024N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/2 (0%)     0/1 (0%)    |3/3 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/2.00       0/1.00      |3/3.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |100.0%       0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/2 (0%)     0/1 (0%)    |2/2 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |722          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/39.84      1/42.57      0/42.93      2/41.13     |                                                    | 
|POLY-3 PERCENT (g) |     2.5%         2.4%         0.0%         4.9%        |                                                    | 
|TERMINAL (d)       |     1/20 (5%)    1/29 (3%)    0/26 (0%)    1/27 (4%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          684         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.416      P=0.677N     P=0.448N     P=0.597     |                                                    | 
|POLY 3             |     P=0.372      P=0.746N     P=0.485N     P=0.511     |                                                    | 
|POLY 1.5           |     P=0.369      P=0.754N     P=0.494N     P=0.504     |                                                    | 
|POLY 6             |     P=0.377      P=0.730N     P=0.471N     P=0.528     |                                                    | 
|LOGISTIC REGRESSION|     P=0.385      P=0.677N     (e)          P=0.545     |                                                    | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.505N     P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     3/40.31      0/42.57      1/43.41      0/40.96     |                                                    | 
|POLY-3 PERCENT (g) |     7.4%         0.0%         2.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     628          ---          584          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.077N     P=0.082N     P=0.246N     P=0.096N    |                                                    | 
|POLY 3             |     P=0.087N     P=0.109N     P=0.279N     P=0.115N    |                                                    | 
|POLY 1.5           |     P=0.086N     P=0.114N     P=0.294N     P=0.118N    |                                                    | 
|POLY 6             |     P=0.091N     P=0.098N     P=0.255N     P=0.109N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.088N     P=0.114N     P=0.336N     P=0.117N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.087N     P=0.121N     P=0.316N     P=0.121N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/49 (6%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/39.84      2/42.57      3/42.96      0/40.96     |                                                    | 
|POLY-3 PERCENT (g) |     2.5%         4.7%         7.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/20 (5%)    2/29 (7%)    2/26 (8%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      722          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.270N     P=0.630      P=0.414      P=0.440N    |                                                    | 
|POLY 3             |     P=0.329N     P=0.523      P=0.332      P=0.494N    |                                                    | 
|POLY 1.5           |     P=0.335N     P=0.510      P=0.316      P=0.498N    |                                                    | 
|POLY 6             |     P=0.316N     P=0.548      P=0.359      P=0.486N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.270N     P=0.630      P=0.432      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.338N     P=0.500      P=0.301      P=0.500N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  8/50 (16%)   8/49 (16%)   6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     12/42.12     8/43.63      8/44.56      6/42.45     |                                                    | 
|POLY-3 PERCENT (g) |     28.5%        18.3%        18.0%        14.1%       |                                                    | 
|TERMINAL (d)       |     4/20 (20%)   5/29 (17%)   3/26 (12%)   3/27 (11%)  |                                                    | 
|FIRST INCIDENCE    |     477          493          528          538         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063N     P=0.091N     P=0.116N     P=0.060N    |                                                    | 
|POLY 3             |     P=0.086N     P=0.194N     P=0.180N     P=0.085N    |                                                    | 
|POLY 1.5           |     P=0.089N     P=0.213N     P=0.207N     P=0.092N    |                                                    | 
|POLY 6             |     P=0.080N     P=0.161N     P=0.143N     P=0.074N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.220N     P=0.269N     P=0.097N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.092N     P=0.227N     P=0.242N     P=0.096N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      1/43.18      2/42.11     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         4.8%        |                                                    | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          661          533         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.069      (e)          P=0.549      P=0.232     |                                                    | 
|POLY 3             |     P=0.073      (e)          P=0.516      P=0.249     |                                                    | 
|POLY 1.5           |     P=0.072      (e)          P=0.507      P=0.243     |                                                    | 
|POLY 6             |     P=0.076      (e)          P=0.531      P=0.263     |                                                    | 
|LOGISTIC REGRESSION|     P=0.076      (e)          P=0.482      P=0.264     |                                                    | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.495      P=0.247     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    6/50 (12%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/39.84      1/42.65      2/43.82      6/41.13     |0/43.71      1/41.94      0/42.55      1/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         2.3%         4.6%         14.6%       |0.0%         2.4%         0.0%         2.4%         | 
|TERMINAL (d)       |     2/20 (10%)   0/29 (0%)    2/26 (8%)    5/27 (19%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      709          729 (T)      685         |---          668          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.050      P=0.367N     P=0.599N     P=0.241     |P=0.403      P=0.495      (e)          P=0.481      | 
|POLY 3             |     P=0.032 *    P=0.476N     P=0.660N     P=0.141     |P=0.397      P=0.492      (e)          P=0.495      | 
|POLY 1.5           |     P=0.032 *    P=0.490N     P=0.676N     P=0.136     |P=0.402      P=0.496      (e)          P=0.497      | 
|POLY 6             |     P=0.032 *    P=0.451N     P=0.633N     P=0.155     |P=0.391      P=0.485      (e)          P=0.491      | 
|LOGISTIC REGRESSION|     P=0.038 *    P=0.395N     P=0.599N     P=0.204     |P=0.403      P=0.503      (e)          P=0.481      | 
|COCH-ARM / FISHERS |     P=0.033 *    P=0.500N     P=0.691N     P=0.134     |P=0.405      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/41.04      2/42.65      3/44.84      3/40.96     |0/43.71      0/41.70      1/42.63      0/42.54      | 
|POLY-3 PERCENT (g) |     9.8%         4.7%         6.7%         7.3%        |0.0%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    1/29 (3%)    1/26 (4%)    3/27 (11%)  |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     610          709          392          729 (T)     |---          ---          710          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.439N     P=0.255N     P=0.415N     P=0.416N    |P=0.685      (e)          P=0.477      (e)          | 
|POLY 3             |     P=0.503N     P=0.319N     P=0.452N     P=0.501N    |P=0.688      (e)          P=0.495      (e)          | 
|POLY 1.5           |     P=0.502N     P=0.330N     P=0.472N     P=0.503N    |P=0.692      (e)          P=0.497      (e)          | 
|POLY 6             |     P=0.504N     P=0.296N     P=0.422N     P=0.492N    |P=0.684      (e)          P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.340N     P=0.597N     P=0.495N    |P=0.691      (e)          P=0.494      (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.339N     P=0.500N     P=0.500N    |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/48 (2%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.08      0/42.57      1/42.77      0/40.96     |3/44.09      1/41.91      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         2.3%         0.0%        |6.8%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    0/27 (0%)   |2/33 (6%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     666          ---          729 (T)      ---         |624          675          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.382N     P=0.461N     P=0.708N     P=0.488N    |P=0.050N     P=0.381N     P=0.143N     P=0.140N     | 
|POLY 3             |     P=0.410N     P=0.488N     P=0.746N     P=0.496N    |P=0.042N*    P=0.323N     P=0.125N     P=0.125N     | 
|POLY 1.5           |     P=0.408N     P=0.495N     P=0.756N     P=0.499N    |P=0.043N*    P=0.314N     P=0.123N     P=0.122N     | 
|POLY 6             |     P=0.414N     P=0.475N     P=0.730N     P=0.488N    |P=0.042N*    P=0.338N     P=0.129N     P=0.130N     | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.502N     P=0.753N     P=0.500N    |P=0.044N*    P=0.308N     P=0.122N     P=0.122N     | 
|COCH-ARM / FISHERS |     P=0.406N     P=0.500N     P=0.742      P=0.500N    |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   16/50 (32%)  12/48 (25%)  11/50 (22%) |2/50 (4%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/40.73      16/44.12     12/44.30     11/41.72    |2/43.71      3/41.97      1/42.67      0/42.54      | 
|POLY-3 PERCENT (g) |     17.2%        36.3%        27.1%        26.4%       |4.6%         7.2%         2.3%         0.0%         | 
|TERMINAL (d)       |     4/20 (20%)   11/29 (38%)  5/26 (19%)   8/27 (30%)  |2/33 (6%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     610          493          528          631         |731 (T)      675          698          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.142      P=0.349      P=0.403     |P=0.117N     P=0.388      P=0.539N     P=0.259N     | 
|POLY 3             |     P=0.406      P=0.038 *    P=0.201      P=0.227     |P=0.107N     P=0.481      P=0.508N     P=0.243N     | 
|POLY 1.5           |     P=0.390      P=0.031 *    P=0.167      P=0.219     |P=0.106N     P=0.491      P=0.506N     P=0.240N     | 
|POLY 6             |     P=0.442      P=0.056      P=0.258      P=0.251     |P=0.110N     P=0.467      P=0.513N     P=0.248N     | 
|LOGISTIC REGRESSION|     P=0.401      P=0.040 *    P=0.165      P=0.259     |P=0.108N     P=0.458      P=0.518N     (e)          | 
|COCH-ARM / FISHERS |     P=0.384      P=0.028 *    P=0.131      P=0.218     |P=0.104N     P=0.500      P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/40.67      0/42.57      0/42.77      0/40.96     |1/44.68      0/41.70      0/42.55      2/43.86      | 
|POLY-3 PERCENT (g) |     9.8%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     1/20 (5%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     612          ---          ---          ---         |234          ---          ---          332          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.016N*    P=0.041N*    P=0.041N*    P=0.052N    |P=0.247      P=0.500N     P=0.504N     P=0.497      | 
|POLY 3             |     P=0.019N*    P=0.054N     P=0.053N     P=0.058N    |P=0.250      P=0.514N     P=0.510N     P=0.494      | 
|POLY 1.5           |     P=0.019N*    P=0.058N     P=0.059N     P=0.060N    |P=0.248      P=0.508N     P=0.507N     P=0.496      | 
|POLY 6             |     P=0.020N*    P=0.048N*    P=0.047N*    P=0.055N    |P=0.252      P=0.522N     P=0.513N     P=0.489      | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.063N     P=0.072N     P=0.063N    |P=0.185      (e)          P=0.335N     P=0.457      | 
|COCH-ARM / FISHERS |     P=0.021N*    P=0.059N     P=0.064N     P=0.059N    |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/50 (8%)    1/48 (2%)    0/50 (0%)   |0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/42.58      4/43.05      1/42.99      0/40.96     |0/43.71      3/42.25      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     18.8%        9.3%         2.3%         0.0%        |0.0%         7.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/20 (5%)    3/29 (10%)   0/26 (0%)    0/27 (0%)   |0/33 (0%)    1/24 (4%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     502          584          671          ---         |---          582          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.123N     P=0.013N*    P=0.006N**  |P=0.321N     P=0.090      (e)          (e)          | 
|POLY 3             |     P<0.001N**   P=0.169N     P=0.014N*    P=0.004N**  |P=0.322N     P=0.112      (e)          (e)          | 
|POLY 1.5           |     P<0.001N**   P=0.176N     P=0.016N*    P=0.004N**  |P=0.315N     P=0.116      (e)          (e)          | 
|POLY 6             |     P<0.001N**   P=0.152N     P=0.012N*    P=0.004N**  |P=0.331N     P=0.107      (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.186N     P=0.046N*    P=0.004N**  |P=0.311N     P=0.121      (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.178N     P=0.018N*    P=0.003N**  |P=0.311N     P=0.121      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/48 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.84      2/42.94      1/42.78      1/41.32     |0/43.71      0/41.70      1/43.35      1/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.3%         2.4%        |0.0%         0.0%         2.3%         2.4%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     ---          677          728          629         |---          ---          421          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.539      P=0.316      P=0.560      P=0.516     |P=0.239      (e)          P=0.500      P=0.481      | 
|POLY 3             |     P=0.517      P=0.254      P=0.514      P=0.507     |P=0.233      (e)          P=0.498      P=0.495      | 
|POLY 1.5           |     P=0.506      P=0.244      P=0.504      P=0.503     |P=0.235      (e)          P=0.499      P=0.497      | 
|POLY 6             |     P=0.539      P=0.273      P=0.529      P=0.517     |P=0.230      (e)          P=0.496      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.499      P=0.239      P=0.569      P=0.503     |P=0.228      (e)          P=0.570      P=0.481      | 
|COCH-ARM / FISHERS |     P=0.499      P=0.247      P=0.490      P=0.500     |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/40.32      0/42.57      0/42.93      2/41.34     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         0.0%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     589          ---          ---          623         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253      P=0.513N     P=0.504N     P=0.527     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.244      P=0.489N     P=0.487N     P=0.509     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.245      P=0.496N     P=0.495N     P=0.503     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.242      P=0.477N     P=0.475N     P=0.523     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.248      P=0.488N     P=0.550N     P=0.500     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.505N     P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/39.95      1/42.85      0/42.93      1/41.50     |1/44.29      0/41.70      0/42.55      2/43.35      | 
|POLY-3 PERCENT (g) |     2.5%         2.3%         0.0%         2.4%        |2.3%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     701          652          ---          561         |548          ---          ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.619N     P=0.701N     P=0.445N     P=0.754N    |P=0.244      P=0.504N     P=0.500N     P=0.484      | 
|POLY 3             |     P=0.610N     P=0.745N     P=0.486N     P=0.753N    |P=0.249      P=0.512N     P=0.508N     P=0.493      | 
|POLY 1.5           |     P=0.613N     P=0.754N     P=0.494N     P=0.757N    |P=0.247      P=0.506N     P=0.505N     P=0.497      | 
|POLY 6             |     P=0.608N     P=0.728N     P=0.472N     P=0.742N    |P=0.250      P=0.521N     P=0.513N     P=0.486      | 
|LOGISTIC REGRESSION|     P=0.614N     P=0.762N     P=0.480N     P=0.760N    |P=0.237      P=0.521N     P=0.470N     P=0.486      | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.753N     P=0.505N     P=0.753N    |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/49 (8%)    3/50 (6%)   |5/50 (10%)   5/50 (10%)   1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/41.08      3/43.04      4/44.23      3/42.20     |5/45.34      5/43.23      1/42.84      1/43.30      | 
|POLY-3 PERCENT (g) |     7.3%         7.0%         9.0%         7.1%        |11.0%        11.6%        2.3%         2.3%         | 
|TERMINAL (d)       |     0/20 (0%)    1/29 (3%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     589          608          528          332         |519          499          652          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.565N     P=0.597N     P=0.582      P=0.636N    |P=0.045N*    P=0.553      P=0.121N     P=0.125N     | 
|POLY 3             |     P=0.568      P=0.641N     P=0.540      P=0.651N    |P=0.037N*    P=0.600      P=0.115N     P=0.112N     | 
|POLY 1.5           |     P=0.563      P=0.654N     P=0.517      P=0.657N    |P=0.036N*    P=0.616      P=0.109N     P=0.107N     | 
|POLY 6             |     P=0.577      P=0.616N     P=0.577      P=0.637N    |P=0.040N*    P=0.574      P=0.123N     P=0.121N     | 
|LOGISTIC REGRESSION|     P=0.561      P=0.656      P=0.391      P=0.640N    |P=0.031N*    P=0.617N     P=0.092N     P=0.097N     | 
|COCH-ARM / FISHERS |     P=0.556      P=0.661N     P=0.489      P=0.661N    |P=0.035N*    P=0.630N     P=0.102N     P=0.102N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/49 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/39.93      0/42.57      3/43.27      2/41.50     |0/43.71      0/41.70      2/43.61      2/43.35      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         6.9%         4.8%        |0.0%         0.0%         4.6%         4.6%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    1/27 (4%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     708          ---          661          561         |---          ---          421          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268      P=0.422N     P=0.425      P=0.551     |P=0.085      (e)          P=0.237      P=0.225      | 
|POLY 3             |     P=0.244      P=0.487N     P=0.334      P=0.514     |P=0.087      (e)          P=0.236      P=0.235      | 
|POLY 1.5           |     P=0.242      P=0.494N     P=0.317      P=0.506     |P=0.087      (e)          P=0.237      P=0.237      | 
|POLY 6             |     P=0.249      P=0.473N     P=0.363      P=0.530     |P=0.087      (e)          P=0.235      P=0.232      | 
|LOGISTIC REGRESSION|     P=0.242      P=0.471N     P=0.339      P=0.500     |P=0.077      (e)          P=0.264      P=0.226      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.500N     P=0.301      P=0.500     |P=0.086      (e)          P=0.247      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/40.34      1/42.95      2/43.49      1/41.32     |0/43.71      0/41.70      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         2.3%         4.6%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     610          620          633          629         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.447N     P=0.601N     P=0.470N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.445N     P=0.478N     P=0.667N     P=0.492N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.445N     P=0.491N     P=0.683N     P=0.497N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.442N     P=0.455N     P=0.640N     P=0.478N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.445N     P=0.506N     P=0.658      P=0.500N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.445N     P=0.500N     P=0.684      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Artery                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      2/44.08      0/40.96     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    1/26 (4%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          661          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.621      (e)          P=0.297      (e)         |                                                    | 
|POLY 3             |     P=0.594      (e)          P=0.260      (e)         |                                                    | 
|POLY 1.5           |     P=0.593      (e)          P=0.249      (e)         |                                                    | 
|POLY 6             |     P=0.602      (e)          P=0.278      (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.598      (e)          P=0.252      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   13/50 (26%)  10/50 (20%) |                                                    | 
|POLY-3 RATE (b)    |     6/40.41      6/43.32      13/45.57     10/41.65    |                                                    | 
|POLY-3 PERCENT (g) |     14.9%        13.9%        28.5%        24.0%       |                                                    | 
|TERMINAL (d)       |     3/20 (15%)   4/29 (14%)   5/26 (19%)   8/27 (30%)  |                                                    | 
|FIRST INCIDENCE    |     624          548          519          623         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.191      P=0.402N     P=0.204      P=0.381     |                                                    | 
|POLY 3             |     P=0.109      P=0.572N     P=0.100      P=0.219     |                                                    | 
|POLY 1.5           |     P=0.108      P=0.599N     P=0.080      P=0.210     |                                                    | 
|POLY 6             |     P=0.117      P=0.521N     P=0.140      P=0.244     |                                                    | 
|LOGISTIC REGRESSION|     P=0.113      P=0.571N     P=0.084      P=0.255     |                                                    | 
|COCH-ARM / FISHERS |     P=0.110      P=0.620N     P=0.062      P=0.207     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   5/50 (10%)   3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     2/40.13      7/43.89      5/45.27      3/42.64     |                                                    | 
|POLY-3 PERCENT (g) |     5.0%         16.0%        11.0%        7.0%        |                                                    | 
|TERMINAL (d)       |     1/20 (5%)    4/29 (14%)   2/26 (8%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     652          493          519          542         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.459N     P=0.168      P=0.314      P=0.516     |                                                    | 
|POLY 3             |     P=0.470N     P=0.100      P=0.267      P=0.528     |                                                    | 
|POLY 1.5           |     P=0.494N     P=0.089      P=0.244      P=0.513     |                                                    | 
|POLY 6             |     P=0.429N     P=0.124      P=0.305      P=0.555     |                                                    | 
|LOGISTIC REGRESSION|     P=0.516N     P=0.080      P=0.174      P=0.517     |                                                    | 
|COCH-ARM / FISHERS |     P=0.517N     P=0.080      P=0.218      P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   4/50 (8%)    4/49 (8%)    7/50 (14%)  |6/50 (12%)   5/50 (10%)   2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     9/41.26      4/42.78      4/43.91      7/41.75     |6/44.29      5/42.83      2/42.91      5/43.08      | 
|POLY-3 PERCENT (g) |     21.8%        9.4%         9.1%         16.8%       |13.6%        11.7%        4.7%         11.6%        | 
|TERMINAL (d)       |     5/20 (25%)   3/29 (10%)   1/26 (4%)    5/27 (19%)  |4/33 (12%)   2/24 (8%)    0/29 (0%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     617          673          528          542         |638          499          652          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346N     P=0.044N*    P=0.063N     P=0.241N    |P=0.425N     P=0.606      P=0.172N     P=0.558N     | 
|POLY 3             |     P=0.438N     P=0.098N     P=0.090N     P=0.380N    |P=0.411N     P=0.524N     P=0.142N     P=0.520N     | 
|POLY 1.5           |     P=0.441N     P=0.109N     P=0.104N     P=0.389N    |P=0.406N     P=0.510N     P=0.139N     P=0.509N     | 
|POLY 6             |     P=0.435N     P=0.080N     P=0.071N     P=0.356N    |P=0.416N     P=0.546N     P=0.148N     P=0.533N     | 
|LOGISTIC REGRESSION|     P=0.439N     P=0.094N     P=0.129N     P=0.373N    |P=0.403N     P=0.501N     P=0.139N     P=0.513N     | 
|COCH-ARM / FISHERS |     P=0.443N     P=0.117N     P=0.125N     P=0.393N    |P=0.401N     P=0.500N     P=0.134N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.84      0/42.57      2/42.93      0/40.96     |0/43.71      0/41.70      1/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/20 (0%)    0/29 (0%)    2/26 (8%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    1/29 (3%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.635      (e)          P=0.297      (e)         |P=0.687      (e)          P=0.474      (e)          | 
|POLY 3             |     P=0.594      (e)          P=0.254      (e)         |P=0.689      (e)          P=0.495      (e)          | 
|POLY 1.5           |     P=0.592      (e)          P=0.244      (e)         |P=0.692      (e)          P=0.497      (e)          | 
|POLY 6             |     P=0.602      (e)          P=0.271      (e)         |P=0.684      (e)          P=0.491      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.297      (e)         |(e)          (e)          P=0.474      (e)          | 
|COCH-ARM / FISHERS |     P=0.594      (e)          P=0.242      (e)         |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/2 (0%)    |0/0 (0%)     0/2 (0%)     3/4 (75%)    0/2 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/0.51       0/1.50      |0/0.00       0/1.86       3/3.81       0/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         78.8%        0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |0/0 (0%)     0/1 (0%)     1/1 (100%)   0/2 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          707          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.616N     (e)          P=0.223      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.476N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.567N     (e)          P=1.000      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     1/1 (100%)   1/2 (50%)   |0/0 (0%)     0/2 (0%)     0/4 (0%)     2/2 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       1/1.00       1/1.50      |0/0.00       0/1.86       0/3.69       2/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         100.0%       66.7%       |0.0%         0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)  |0/0 (0%)     0/1 (0%)     0/1 (0%)     2/2 (100%)   | 
|FIRST INCIDENCE    |     ---          ---          584          729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.723      (e)          (e)          P=1.000     |P=0.159      (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=1.000     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.667N     (e)          (e)          P=1.000     |P=0.031 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/7 (100%)   1/1 (100%)   2/2 (100%)   4/5 (80%)   |3/3 (100%)   1/2 (50%)    1/2 (50%)    1/1 (100%)   | 
|POLY-3 RATE (b)    |     7/7.00       1/1.00       2/2.00       4/4.41      |3/3.00       1/1.48       1/1.48       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       90.7%       |100.0%       67.7%        67.6%        100.0%       | 
|TERMINAL (d)       |     3/3 (100%)   0/0 (0%)     0/0 (0%)     1/1 (100%)  |2/2 (100%)   0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     589          485          680          533         |638          695          638          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511N     (e)          (e)          P=0.451N    |P=0.332N     P=0.714      P=0.744      (e)          | 
|POLY 3             |     P=0.467N     (e)          (e)          P=0.882N    |P=0.813N     P=0.774N     P=0.771N     (e)          | 
|POLY 1.5           |     P=0.321N     (e)          (e)          P=0.640N    |P=0.702N     P=0.570N     P=0.569N     (e)          | 
|POLY 6             |     P=0.920N     (e)          (e)          P=1.000N    |P=0.983N     P=0.997N     P=0.997N     (e)          | 
|LOGISTIC REGRESSION|     P=0.301N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.219N     (e)          (e)          P=0.417N    |P=0.623N     P=0.400N     P=0.400N     (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/48 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/39.65      0/42.57      1/42.46      1/41.09     |0/43.71      1/41.76      0/42.55      0/42.54      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         2.4%         2.4%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/19 (0%)    0/29 (0%)    0/26 (0%)    0/27 (0%)   |0/33 (0%)    0/24 (0%)    0/29 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     477          ---          661          695         |---          717          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481N     P=0.199N     P=0.430N     P=0.455N    |P=0.575N     P=0.450      (e)          (e)          | 
|POLY 3             |     P=0.501N     P=0.221N     P=0.476N     P=0.487N    |P=0.575N     P=0.491      (e)          (e)          | 
|POLY 1.5           |     P=0.498N     P=0.228N     P=0.491N     P=0.492N    |P=0.571N     P=0.496      (e)          (e)          | 
|POLY 6             |     P=0.506N     P=0.207N     P=0.450N     P=0.474N    |P=0.580N     P=0.484      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.496N     P=0.221N     P=0.576N     P=0.489N    |P=0.571N     P=0.482      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.497N     P=0.242N     P=0.508N     P=0.492N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 07                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                 VANADIUM PENTOXIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      0.5          1.0          2.0         |CONTROL      0.5          1.0          2.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    1/50 (2%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |0/43.71      1/41.70      4/42.55      4/42.54      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.4%         9.4%         9.4%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    1/24 (4%)    4/29 (14%)   4/30 (13%)   | 
|FIRST INCIDENCE    |                                                        |---          731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.029 *    P=0.436      P=0.047 *    P=0.051      | 
|POLY 3             |                                                        |P=0.026 *    P=0.491      P=0.056      P=0.056      | 
|POLY 1.5           |                                                        |P=0.027 *    P=0.495      P=0.058      P=0.059      | 
|POLY 6             |                                                        |P=0.024 *    P=0.483      P=0.054      P=0.054      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.436      P=0.047 *    P=0.051      | 
|COCH-ARM / FISHERS |                                                        |P=0.029 *    P=0.500      P=0.059      P=0.059      | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).