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TDMS Study 61427-08 Pathology Tables

NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29

                                                          FINAL#2/MICE




       Facility:  Battelle Northwest

       Chemical CAS #:  1314-62-1

       Lock Date:  11/02/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8           10           14           16                                     
    Natural Death                                      4            5            4            2                                     
    Accidently Killed                                               3            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           32           29           32                                     
    Moribund Sacrifice                                                           1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (41)         (43)         (45)                                   
      Inflammation, Suppurative                        1 [1.0]      1 [1.0]                                                         
   Intestine Small, Duodenum                          (47)         (43)         (46)         (49)                                   
      Inflammation, Suppurative                        1 [1.0]      1 [2.0]                                                         
      Ulcer                                                         1 [2.0]                                                         
      Epithelium, Hyperplasia                                                    1 [2.0]                                            
   Intestine Small, Jejunum                           (47)         (43)         (45)         (50)                                   
      Inflammation                                                  1 [3.0]                                                         
   Intestine Small, Ileum                             (47)         (43)         (46)         (50)                                   
      Inflammation, Suppurative                        1 [3.0]      1 [2.0]                                                         
      Ulcer                                            1 [2.0]                                                                      
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 [1.0]      1 [4.0]                                            
      Basophilic Focus                                                                        1                                     
      Clear Cell Focus                                 1                                                                            
      Eosinophilic Focus                              12           12            3            8                                     
      Eosinophilic Focus, Multiple                     4            2            1                                                  
      Fatty Change                                                  1 [4.0]                                                         
      Hematopoietic Cell Proliferation                 4 [1.8]                   6 [2.0]      3 [1.3]                               
      Infiltration Cellular, Mixed Cell                             1 [3.0]                                                         
      Inflammation, Focal, Granulomatous              12 [1.0]     26 [1.0]     19 [1.1]     21 [1.0]                               
      Necrosis, Focal                                  2 [1.5]      6 [1.2]      9 [1.6]      5 [1.2]                               
      Pigmentation, Hemosiderin                        1 [2.0]                   2 [2.0]                                            
      Tension Lipidosis                                2            4            1            2                                     
      Bile Duct, Cyst                                  1 [2.0]      1 [1.0]                   1 [3.0]                               
      Centrilobular, Degeneration                                   1 [3.0]                                                         
      Centrilobular, Inflammation, Chronic                          1 [2.0]                                                         
      Centrilobular, Necrosis                          1 [1.0]                   1 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (14)         (9)          (5)          (4)                                    
      Hemorrhage                                       1 [4.0]                                                                      
      Artery, Inflammation                             1 [2.0]                                                                      
      Fat, Inflammation                                1 [2.0]      1 [3.0]      1 [2.0]                                            
      Fat, Necrosis                                   11 [2.9]      9 [2.6]      5 [1.8]      3 [2.7]                               
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Atrophy                                          3 [2.3]      4 [2.0]      2 [1.0]      4 [1.5]                               
      Duct, Cyst                                                                              1 [4.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            1 [1.0]                                                         
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    2 [2.5]                               
      Inflammation, Suppurative                                                  1 [1.0]      1 [4.0]                               
      Mineralization                                                                          1 [1.0]                               
      Ulcer                                            1 [1.0]      1 [1.0]      2 [1.5]      1 [1.0]                               
      Epithelium, Hyperplasia                          3 [2.0]      1 [1.0]      7 [2.3]      1 [2.0]                               
   Stomach, Glandular                                 (49)         (47)         (48)         (50)                                   
      Inflammation, Suppurative                                     1 [2.0]                   1 [1.0]                               
      Mineralization                                                1 [1.0]                                                         
      Ulcer                                            1 [2.0]      1 [1.0]      1 [1.0]                                            
      Epithelium, Hyperplasia                                                                 1 [1.0]                               
   Tooth                                                                                     (1)                                    
      Malformation                                                                            1                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  47 [1.1]     45 [1.1]     46 [1.1]     49 [1.1]                               
      Inflammation                                                               1 [2.0]                                            
      Mineralization                                   2 [1.5]      1 [1.0]      1 [1.0]                                            
      Artery, Inflammation                             1 [1.0]                                                                      
      Capillary, Hyperplasia                           2 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Degeneration, Cystic                                                       2 [1.5]      2 [2.0]                               
      Hypertrophy                                      5 [1.0]      5 [1.2]      3 [1.0]      7 [1.0]                               
      Capsule, Hyperplasia                             1 [3.0]                                                                      
   Adrenal Medulla                                    (49)         (50)         (48)         (49)                                   
      Hyperplasia                                      4 [1.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                   1 [1.0]                                                         
   Parathyroid Gland                                  (42)         (41)         (43)         (39)                                   
      Cyst                                                          1 [2.0]                                                         
      Hyperplasia                                                   2 [2.5]                   1 [1.0]                               
   Pituitary Gland                                    (49)         (50)         (50)         (47)                                   
      Pars Distalis, Cyst                              2 [1.5]                   1 [1.0]      2 [1.5]                               
      Pars Distalis, Hyperplasia                      22 [2.0]     26 [1.5]     15 [1.9]     20 [1.6]                               
   Thyroid Gland                                      (50)         (50)         (48)         (50)                                   
      Inflammation, Suppurative                                                               2 [1.0]                               
      Follicular Cell, Cyst                                                      1 [2.0]      1 [3.0]                               
      Follicular Cell, Hyperplasia                     1 [1.0]      1 [1.0]      1 [2.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (50)         (49)         (47)                                   
      Angiectasis                                      1 [2.0]      1 [2.0]      1 [2.0]      1 [1.0]                               
      Cyst                                            16 [1.7]     16 [2.4]     15 [2.1]     17 [2.1]                               
      Hemorrhage                                                    1 [4.0]                                                         
      Thrombosis                                       1 [4.0]      1 [4.0]                                                         
   Uterus                                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                      5 [3.0]      4 [2.5]      1 [3.0]                                            
      Hyperplasia, Cystic                             46 [2.8]     43 [2.2]     42 [2.2]     41 [2.7]                               
      Inflammation                                     1 [2.0]                                                                      
      Inflammation, Focal                              1 [2.0]                                                                      
      Thrombosis                                                    1 [3.0]                                                         
      Myometrium, Hyperplasia                          1 [3.0]                                                                      
      Serosa, Fibrosis                                                                        1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      5 [2.0]      1 [2.0]      6 [2.2]      6 [1.8]                               
   Lymph Node                                         (3)          (1)          (5)          (1)                                    
      Angiectasis                                      3 [3.0]      1 [3.0]                                                         
   Lymph Node, Bronchial                              (39)         (40)         (45)         (41)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      3 [2.0]     13 [1.8]     14 [2.3]     20 [2.3]                               
   Lymph Node, Mandibular                             (41)         (40)         (40)         (46)                                   
      Hyperplasia                                                   2 [3.0]      1 [3.0]      3 [2.3]                               
   Lymph Node, Mesenteric                             (46)         (47)         (48)         (50)                                   
      Angiectasis                                                                             1 [2.0]                               
      Hyperplasia                                      2 [2.0]      1 [2.0]      1 [2.0]      1 [2.0]                               
   Lymph Node, Mediastinal                            (43)         (37)         (42)         (42)                                   
      Hyperplasia                                      6 [2.2]      4 [2.3]      5 [2.6]      6 [2.7]                               
   Spleen                                             (50)         (48)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                21 [2.2]     12 [2.1]     18 [2.4]     11 [2.5]                               
      Hyperplasia, Lymphoid                           17 [1.9]     18 [2.1]     15 [2.1]     15 [2.1]                               
   Thymus                                             (44)         (45)         (44)         (41)                                   
      Amyloid Deposition                                            1 [3.0]                                                         
      Angiectasis                                                   1 [2.0]                                                         
      Hyperplasia                                      1 [3.0]      1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      3 [2.0]                   4 [1.8]                                            
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 [3.0]                                                                      
      Inflammation, Suppurative                        1 [4.0]      2 [4.0]                                                         
      Epidermis, Hyperplasia                                        1 [3.0]                                                         
      Subcutaneous Tissue, Inflammation, Chronic                                 1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                          28 [1.2]     21 [1.2]     22 [1.3]     32 [1.5]                               
      Fracture                                                                   3                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 [2.0]                                            
      Hydrocephalus                                    1 [2.0]      1 [2.0]                                                         
      Necrosis                                         2 [1.0]                   2 [1.0]                                            
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                      2 [2.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Meninges, Inflammation                                        1 [2.0]      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (49)         (50)                                   
      Inflammation, Suppurative                        3 [1.0]      2 [1.0]      3 [1.0]      1 [1.0]                               
      Respiratory Epithelium, Epiglottis,                                                                                           
          Metaplasia, Squamous                                     39 [1.0]     45 [1.0]     44 [1.1]                               
      Squamous Epithelium, Hyperplasia                15 [1.1]     10 [1.1]     17 [1.4]     14 [1.1]                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                            1 [2.0]                                                         
      Hemorrhage                                       4 [1.3]      3 [1.0]      4 [1.8]      4 [1.3]                               
      Infiltration Cellular, Mast Cell                              1 [3.0]                                                         
      Inflammation, Chronic                            4 [1.0]     37 [1.3]     39 [1.8]     49 [2.0]                               
      Inflammation, Chronic, Focal                                  1 [2.0]                                                         
      Metaplasia, Osseous                              1 [4.0]                                                                      
      Mineralization                                   1 [2.0]                                                                      
      Thrombosis                                       1 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia                             31 [1.6]     38 [2.0]     50 [3.3]                               
      Alveolus, Infiltration Cellular, Histiocyte                  34 [2.4]     35 [2.4]     45 [2.7]                               
      Bronchiole, Epithelium, Hyperplasia                          12 [1.0]     34 [1.0]     48 [1.5]                               
      Interstitium, Fibrosis                                        1 [2.0]      4 [2.5]      8 [1.5]                               
      Perivascular, Infiltration Cellular              2 [1.5]      2 [2.5]      3 [2.7]                                            
   Nose                                               (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte                                                       1 [4.0]                               
      Inflammation, Chronic                                                      2 [3.0]                                            
      Inflammation, Suppurative                       19 [1.1]     14 [1.2]     32 [1.2]     30 [1.3]                               
      Lateral Wall, Hyperplasia                                                  1 [2.0]      2 [1.5]                               
      Lateral Wall, Metaplasia, Squamous               1 [1.0]      1 [2.0]      4 [1.8]      1 [1.0]                               
      Olfactory Epithelium, Atrophy                    2 [1.5]      8 [1.3]      5 [1.0]     14 [1.3]                               
      Olfactory Epithelium, Degeneration, Hyaline     11 [1.2]     23 [1.0]     34 [1.2]     48 [1.3]                               
      Respiratory Epithelium, Degeneration, Hyaline   35 [1.3]     39 [1.5]     46 [1.7]     50 [1.8]                               
      Respiratory Epithelium, Hyperplasia              1 [1.0]                   1 [1.0]      1 [1.0]                               
      Respiratory Epithelium, Metaplasia, Squamous                  3 [1.3]      7 [1.1]      8 [1.1]                               
      Respiratory Epithelium, Necrosis                                           1 [2.0]      7 [1.4]                               
   Pleura                                                          (1)                       (1)                                    
      Mesothelium, Hyperplasia                                      1 [4.0]                   1 [2.0]                               
   Trachea                                            (50)         (49)         (47)         (50)                                   
      Inflammation, Suppurative                                     1 [1.0]                                                         
      Metaplasia, Squamous                                                                    1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Anterior Chamber, Cornea, Inflammation                                     1 [4.0]                                            
   Harderian Gland                                    (3)          (1)          (1)                                                 
      Inflammation, Focal, Granulomatous               1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Accumulation, Hyaline Droplet                    2 [4.0]      1 [2.0]                   1 [3.0]                               
      Cyst                                             1 [2.0]      1 [1.0]                   1 [1.0]                               
      Glomerulosclerosis                               1 [4.0]                                                                      
      Infiltration Cellular, Mononuclear Cell                       1 [2.0]                                                         
      Metaplasia, Osseous                              3 [1.3]      3 [1.0]      1 [1.0]      2 [1.0]                               
      Nephropathy                                     43 [1.1]     33 [1.1]     43 [1.0]     39 [1.0]                               
      Pigmentation, Hemosiderin                        1 [2.0]                                                                      
      Artery, Inflammation                             1 [2.0]                   1 [2.0]                                            
      Renal Tubule, Degeneration, Hyaline                                        1 [2.0]                                            
      Renal Tubule, Pigmentation, Hemosiderin          1 [2.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            6            1            3                                     
    Moribund Sacrifice                                 7           11           13           20                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           33           36           27                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)                                   
      Inflammation                                     2 [1.5]                                                                      
   Intestine Small, Jejunum                           (46)         (48)         (49)         (47)                                   
      Inflammation                                                               1 [2.0]                                            
   Intestine Small, Ileum                             (46)         (49)         (50)         (48)                                   
      Inflammation, Chronic                            1 [2.0]                                                                      
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 [1.0]                                            
      Basophilic Focus                                 2                                                                            
      Clear Cell Focus                                 4            2                                                               
      Clear Cell Focus, Multiple                                    1                                                               
      Eosinophilic Focus                              19           11           14           17                                     
      Eosinophilic Focus, Multiple                     1            5            5            2                                     
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Infarct                                                       1 [4.0]                                                         
      Inflammation, Focal, Granulomatous               2 [1.0]      6 [1.3]      7 [1.1]      3 [1.3]                               
      Mixed Cell Focus                                 1                                                                            
      Necrosis, Focal                                  8 [1.0]      3 [1.3]      5 [1.4]      4 [1.3]                               
      Pigmentation, Hemosiderin                                                  3 [1.7]      1 [3.0]                               
      Tension Lipidosis                                2            4            2            3                                     
      Vacuolization Cytoplasmic                        1 [2.0]      1 [2.0]                                                         
      Centrilobular, Degeneration                      1 [2.0]      1 [1.0]      1 [2.0]                                            
      Centrilobular, Necrosis                                       1 [1.0]                                                         
   Mesentery                                          (9)          (7)          (8)          (1)                                    
      Artery, Inflammation                             1 [2.0]                                                                      
      Fat, Inflammation                                3 [2.3]                   3 [2.7]                                            
      Fat, Necrosis                                    5 [2.8]      3 [2.7]      4 [2.5]      1 [2.0]                               
   Oral Mucosa                                                     (1)                                                              
      Pharyngeal, Cyst                                              1 [2.0]                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                          3 [1.0]      3 [1.0]      5 [1.0]      2 [1.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Inflammation                                                  4 [1.8]      2 [1.5]                                            
      Necrosis                                                                   1 [2.0]                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 [2.0]                               
      Inflammation, Suppurative                                     2 [1.0]      1 [2.0]                                            
      Mineralization                                                1 [1.0]                                                         
      Ulcer                                            1 [1.0]      2 [1.0]      2 [1.5]      1 [1.0]                               
      Epithelium, Hyperplasia                          3 [2.3]     10 [2.0]      6 [2.5]      4 [2.3]                               
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Infiltration Cellular                                         1 [2.0]                                                         
      Inflammation, Suppurative                                     1 [1.0]      1 [1.0]                                            
      Mineralization                                                             1 [1.0]                                            
      Ulcer                                                                      1 [2.0]      1 [1.0]                               
      Epithelium, Hyperplasia                                       1 [1.0]                   1 [2.0]                               
   Tooth                                              (2)          (1)          (2)                                                 
      Inflammation                                                  1 [2.0]                                                         
      Malformation                                     2            1            2                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [1.0]                                                                      
      Cardiomyopathy                                  48 [1.1]     48 [1.1]     48 [1.2]     47 [1.2]                               
      Mineralization                                                1 [1.0]                                                         
      Thrombosis                                       1 [3.0]                                                                      
      Artery, Inflammation                             1 [2.0]      1 [2.0]                   1 [2.0]                               
      Capillary, Hyperplasia                           1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Degeneration, Cystic                                          1 [2.0]                                                         
      Hyperplasia                                      9 [2.7]                   2 [3.0]                                            
      Hypertrophy                                     40 [1.5]     36 [1.4]     31 [1.4]     31 [1.2]                               
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Hyperplasia                                                   2 [2.5]      1 [4.0]      1 [1.0]                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 [1.4]      6 [1.0]      1 [2.0]      2 [1.0]                               
   Pituitary Gland                                    (50)         (48)         (49)         (49)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              2 [1.5]      3 [1.7]      3 [1.3]                                            
      Pars Distalis, Hyperplasia                       4 [1.5]      3 [1.7]                   1 [2.0]                               
   Thyroid Gland                                      (48)         (50)         (50)         (50)                                   
      Follicular Cell, Hyperplasia                     1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 [3.0]                                1 [2.0]                               
      Inflammation                                     3 [1.3]                   1 [2.0]                                            
   Preputial Gland                                    (49)         (50)         (50)         (49)                                   
      Ectasia                                         15 [3.2]     19 [2.6]     13 [2.4]     20 [2.8]                               
      Inflammation                                     2 [1.0]      5 [2.4]      5 [2.8]      3 [2.0]                               
   Prostate                                           (50)         (49)         (49)         (49)                                   
      Inflammation                                     4 [2.0]      1 [1.0]                                                         
      Inflammation, Suppurative                                     1 [2.0]                                                         
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 [2.0]                                                         
      Inflammation, Chronic                                         2 [2.0]                                                         
      Inflammation, Suppurative                                                  1 [3.0]      1 [4.0]                               
      Epithelium, Degeneration                         1 [2.0]                                                                      
      Epithelium, Hyperplasia                                                                 1 [4.0]                               
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          4 [1.8]      7 [1.3]      1 [1.0]      5 [2.0]                               
      Interstitial Cell, Hyperplasia                   1 [4.0]                                1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      8 [2.0]      5 [2.0]      4 [2.0]      4 [2.0]                               
      Thrombosis                                       1 [2.0]                                                                      
   Lymph Node, Bronchial                              (40)         (38)         (36)         (40)                                   
      Hyperplasia                                      7 [2.1]      7 [2.4]     12 [2.1]     13 [2.2]                               
   Lymph Node, Mandibular                             (34)         (43)         (27)         (35)                                   
      Hyperplasia                                      1 [3.0]                   1 [2.0]      1 [2.0]                               
      Infiltration Cellular, Plasma Cell                                         1 [4.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mesenteric                             (46)         (47)         (48)         (44)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]      2 [1.5]                                            
      Hyperplasia                                      3 [2.0]      7 [2.0]      2 [2.0]      2 [2.0]                               
   Lymph Node, Mediastinal                            (38)         (36)         (43)         (37)                                   
      Hyperplasia                                      2 [2.0]      3 [1.7]      4 [2.3]      6 [2.2]                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 [2.0]                   1 [1.0]                               
      Hematopoietic Cell Proliferation                15 [1.8]     13 [2.2]     18 [2.2]     10 [2.0]                               
      Hyperplasia, Lymphoid                            9 [2.0]     12 [2.3]     15 [2.0]     10 [2.0]                               
      Infiltration Cellular, Histiocyte                             1 [2.0]                                                         
      Inflammation, Focal, Granulomatous                                                      1 [1.0]                               
   Thymus                                             (35)         (40)         (36)         (35)                                   
      Epithelial Cell, Hyperplasia                                                            1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1                                                                            
      Inflammation, Focal, Granulomatous               1 [4.0]                                                                      
      Inflammation, Suppurative                        1 [1.0]                   1 [4.0]      1 [4.0]                               
      Epidermis, Hyperplasia                           2 [2.0]                                                                      
      Prepuce, Inflammation, Chronic Active            7 [2.7]      1 [3.0]      1 [1.0]      2 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 [1.0]      3 [1.0]      2 [1.0]      2 [1.0]                               
      Fracture                                                                   1                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)         (50)                                   
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                                      1 [2.0]                                                         
   Spinal Cord                                                                  (1)                                                 
      Hyperplasia, Lymphoid                                                      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Larynx                                             (49)         (50)         (49)         (50)                                   
      Inflammation, Suppurative                        2 [1.5]                   3 [1.0]                                            
      Respiratory Epithelium, Epiglottis,                                                                                           
          Metaplasia, Squamous                         2 [1.0]     45 [1.0]     41 [1.0]     41 [1.0]                               
      Squamous Epithelium, Hyperplasia                 5 [1.0]      4 [1.3]     11 [1.0]      5 [1.2]                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       2 [2.0]      3 [1.3]      3 [1.0]      1 [2.0]                               
      Inflammation, Chronic                            6 [1.5]     42 [1.5]     45 [1.6]     47 [2.0]                               
      Inflammation, Suppurative                        1 [2.0]                                                                      
      Necrosis                                                      1 [4.0]                                                         
      Thrombosis                                                    1 [1.0]                                                         
      Alveolar Epithelium, Hyperplasia                 3 [3.0]     41 [2.2]     49 [3.3]     50 [3.9]                               
      Alveolus, Infiltration Cellular, Histiocyte     10 [2.4]     36 [2.4]     45 [2.6]     49 [3.0]                               
      Bronchiole, Epithelium, Hyperplasia                          15 [1.0]     37 [1.1]     46 [1.7]                               
      Interstitium, Fibrosis                           1 [1.0]      6 [1.7]      9 [1.2]     12 [1.7]                               
      Mediastinum, Inflammation                        1 [3.0]      1 [2.0]                                                         
   Nose                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 [2.0]                                            
      Inflammation, Chronic                                         1 [4.0]      1 [2.0]                                            
      Inflammation, Suppurative                       16 [1.3]     11 [1.4]     32 [1.2]     23 [1.3]                               
      Lateral Wall, Hyperplasia                                                  2 [1.0]      1 [1.0]                               
      Lateral Wall, Metaplasia, Squamous                            1 [2.0]      1 [1.0]      1 [1.0]                               
      Olfactory Epithelium, Atrophy                    6 [1.0]      7 [1.6]      9 [1.3]     12 [1.2]                               
      Olfactory Epithelium, Degeneration, Hyaline      1 [1.0]      7 [1.0]     23 [1.1]     30 [1.2]                               
      Respiratory Epithelium, Degeneration, Hyaline    8 [1.1]     22 [1.0]     38 [1.2]     41 [1.4]                               
      Respiratory Epithelium, Metaplasia, Squamous                  6 [1.2]      6 [1.3]      2 [1.5]                               
      Respiratory Epithelium, Necrosis                                           1 [1.0]      2 [1.0]                               
   Pleura                                                          (4)          (2)          (2)                                    
      Mesothelium, Hyperplasia                                      4 [2.3]      2 [2.0]      1 [2.0]                               
   Trachea                                            (49)         (50)         (49)         (50)                                   
      Inflammation, Suppurative                        1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                       (1)                                    
      Inflammation                                                                            1 [2.0]                               
      Internal Ear, Necrosis                                                                  1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 61427-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/19/01    
Route: RESPIRATORY EXPOSURE WHOLE BODY                        VANADIUM PENTOXIDE                                  Time: 10:16:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             CONTROL      1.0          2.0          4.0                                    
                                                                   MG/M3        MG/M3        MG/M3                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Accumulation, Hyaline Droplet                                                           1 [2.0]                               
      Atrophy                                                       1 [4.0]                                                         
      Cyst                                             5 [1.4]      3 [1.3]      7 [1.4]      6 [1.5]                               
      Hydronephrosis                                                2 [2.0]                                                         
      Infarct, Chronic                                                           2 [2.5]                                            
      Infiltration Cellular, Lipocyte                               1 [2.0]                                                         
      Metaplasia, Osseous                              2 [1.0]      7 [1.0]      7 [1.0]      1 [1.0]                               
      Mineralization                                                1 [3.0]                                                         
      Nephropathy                                     48 [1.3]     50 [1.3]     48 [1.2]     48 [1.3]                               
      Papilla, Necrosis                                2 [1.5]                                                                      
      Renal Tubule, Hyperplasia                        5 [1.0]      7 [1.0]      2 [1.0]      4 [1.0]                               
      Renal Tubule, Necrosis                           1 [1.0]      2 [1.5]                                                         
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation                                                                            1 [1.0]                               
      Transitional Epithelium, Hyperplasia                                       1 [4.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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