https://ntp.niehs.nih.gov/go/13082

TDMS Study 61427-08 Pathology Tables

NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41
                                                          FINAL#2/MICE
       Facility:  Battelle Northwest
       Chemical CAS #:  1314-62-1
       Lock Date:  11/02/99
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8           10           14           16                                     
    Natural Death                                      4            5            4            2                                     
    Accidently Killed                                               3            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           32           29           32                                     
    Moribund Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (47)         (44)         (48)         (49)                                   
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Duodenum                          (47)         (43)         (46)         (49)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (43)         (45)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (43)         (46)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
      Hepatocellular Carcinoma                         6 (12%)      3 (6%)       4 (8%)       6 (12%)                               
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                           5 (10%)      5 (10%)      9 (18%)      1 (2%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)       2 (4%)                    1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                           1 (2%)                                             
   Mesentery                                          (14)         (9)          (5)          (4)                                    
      Fat, Hemangioma                                                            1 (20%)                                            
      Fat, Schwannoma Malignant, Metastatic, Uterus                                           1 (25%)                               
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                              2 (4%)                                 1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          2 (4%)                                                                       
   Stomach, Glandular                                 (49)         (47)         (48)         (50)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
   Adrenal Medulla                                    (49)         (50)         (48)         (49)                                   
      Pheochromocytoma Benign                          2 (4%)                                 3 (6%)                                
   Pituitary Gland                                    (49)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pars Distalis, Adenoma                           8 (16%)      6 (12%)      7 (14%)      3 (6%)                                
   Thyroid Gland                                      (50)         (50)         (48)         (50)                                   
      Bilateral, Follicular Cell, Adenoma                           1 (2%)                                                          
      C-Cell, Carcinoma                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Peritoneum                                                                                (1)                                    
      Schwannoma Malignant, Metastatic, Uterus                                                1 (100%)                              
   Tissue NOS                                         (1)                                                                           
      Abdominal, Histiocytic Sarcoma                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (48)         (50)         (49)         (47)                                   
      Cystadenoma                                      1 (2%)                    1 (2%)       2 (4%)                                
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       1 (2%)                                             
   Uterus                                             (50)         (49)         (49)         (50)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont                                                                                                               
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                              2 (4%)       1 (2%)                    1 (2%)                                
      Polyp Stromal                                    1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                                            1 (2%)                                             
      Schwannoma Malignant, Metastatic, Uterus                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Lymph Node                                         (3)          (1)          (5)          (1)                                    
      Iliac, Histiocytic Sarcoma                                                 1 (20%)                                            
      Pancreatic, Histiocytic Sarcoma                                            1 (20%)                                            
      Renal, Histiocytic Sarcoma                                                 1 (20%)                                            
   Lymph Node, Bronchial                              (39)         (40)         (45)         (41)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)                    1 (2%)                                
      Histiocytic Sarcoma                                           1 (3%)                    1 (2%)                                
   Lymph Node, Mandibular                             (41)         (40)         (40)         (46)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (3%)       1 (3%)       1 (2%)                                
   Lymph Node, Mesenteric                             (46)         (47)         (48)         (50)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Schwannoma Malignant, Metastatic, Uterus                                                1 (2%)                                
   Lymph Node, Mediastinal                            (43)         (37)         (42)         (42)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)                    1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (3%)       1 (2%)       1 (2%)                                
   Spleen                                             (50)         (48)         (49)         (50)                                   
      Hemangiosarcoma                                  2 (4%)                    1 (2%)       2 (4%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Thymus                                             (44)         (45)         (44)         (41)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     2 (4%)                    2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                                 (1)                                                              
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Larynx                                             (50)         (50)         (49)         (50)                                   
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)      14 (28%)     18 (36%)     13 (26%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        3 (6%)       5 (10%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma                               14 (28%)     13 (26%)     17 (34%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple                      9 (18%)      5 (10%)      5 (10%)                               
      Granular Cell Tumor Malignant, Metastatic,                                                                                    
           Ovary                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         2 (4%)                    2 (4%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (3)          (1)          (1)                                                 
      Adenoma                                                       1 (100%)     1 (100%)                                           
      Bilateral, Adenoma                               2 (67%)                                                                      
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Urinary Bladder                                    (48)         (45)         (48)         (49)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                               7 (14%)      4 (8%)      12 (24%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            32          37          44          40                                       
     Total Primary Neoplasms                           49          67          88          73                                       
   Total Animals with Benign Neoplasms                 19          23          35          27                                       
     Total Benign Neoplasms                            25          34          46          30                                       
   Total Animals with Malignant Neoplasms              17          29          32          32                                       
     Total Malignant Neoplasms                         24          33          42          43                                       
   Total Animals with Metastatic Neoplasms              2           2           3           5                                       
     Total Metastatic Neoplasm                          2           8           3          12                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            6            1            3                                     
    Moribund Sacrifice                                 7           11           13           20                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           33           36           27                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Small, Duodenum                          (48)         (47)         (49)         (45)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (49)         (50)         (48)                                   
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                        10 (20%)     13 (26%)     11 (22%)      9 (18%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)       5 (10%)      3 (6%)       3 (6%)                                
      Hepatocellular Adenoma                          10 (20%)     10 (20%)      8 (16%)      6 (12%)                               
      Hepatocellular Adenoma, Multiple                 5 (10%)      7 (14%)      2 (4%)       1 (2%)                                
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
   Mesentery                                          (9)          (7)          (8)          (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     2 (29%)                                                         
      Hemangioma                                                    1 (14%)                                                         
      Fat, Alveolar/Bronchiolar Carcinoma,                                                                                          
          Metastatic, Lung                                                       1 (13%)                                            
      Fat, Hepatocholangiocarcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (13%)                                            
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
                                                             Page   8                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     2 (4%)       1 (2%)       2 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Pericardium, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Pericardium, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Pheochromocytoma Benign                                                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (48)         (49)         (49)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (48)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Parathyroid Gland                                                1 (2%)                                
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenoma                                                                2 (4%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Prostate                                           (50)         (49)         (49)         (49)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont                                                                                                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                                      (1)                       (1)                                    
      Lumbar, Histiocytic Sarcoma                                   1 (100%)                                                        
   Lymph Node, Bronchial                              (40)         (38)         (36)         (40)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)       1 (3%)       2 (5%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (3%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (3%)                                             
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Lymph Node, Mandibular                             (34)         (43)         (27)         (35)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (46)         (47)         (48)         (44)                                   
      Carcinoma, Metastatic, Tissue NOS                                          1 (2%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Lymph Node, Mediastinal                            (38)         (36)         (43)         (37)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)       2 (5%)       2 (5%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                           1 (3%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         3 (6%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (35)         (40)         (36)         (35)                                   
      Hemangiosarcoma                                               1 (3%)                                                          
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)       1 (2%)                                
      Melanoma Malignant                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (2%)                                
   Skeletal Muscle                                                 (3)          (2)          (3)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     3 (100%)     1 (50%)      3 (100%)                              
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (50%)                                            
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (50)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    12 (24%)     15 (30%)     15 (30%)     10 (20%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)      11 (22%)      5 (10%)                               
      Alveolar/Bronchiolar Carcinoma                  11 (22%)     19 (38%)     14 (28%)     22 (44%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)      10 (20%)     16 (32%)     13 (26%)                               
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   7 (14%)      4 (8%)       4 (8%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         3 (6%)       2 (4%)       5 (10%)                               
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Ear                                                             (1)                       (1)                                    
      Neural Crest Tumor                                            1 (100%)                                                        
   Harderian Gland                                    (8)          (5)          (5)          (2)                                    
      Adenoma                                          6 (75%)      4 (80%)      4 (80%)      1 (50%)                               
      Carcinoma                                                                  1 (20%)      1 (50%)                               
      Bilateral, Adenoma                               2 (25%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     3 (6%)       2 (4%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Papilloma                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                               2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 61427-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         VANADIUM PENTOXIDE                                    Date: 11/19/01  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 10:27:41  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      1.0          2.0          4.0                                       
                                                                MG/M3        MG/M3        MG/M3                                     
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            42          49          47          47                                       
     Total Primary Neoplasms                           75          96          92          81                                       
   Total Animals with Benign Neoplasms                 31          31          36          21                                       
     Total Benign Neoplasms                            44          42          44          26                                       
   Total Animals with Malignant Neoplasms              27          40          38          41                                       
     Total Malignant Neoplasms                         31          53          48          55                                       
   Total Animals with Metastatic Neoplasms              1          11           9          11                                       
     Total Metastatic Neoplasm                          1          23          33          22                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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