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TDMS Study 61427-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:33:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:33:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                VANADIUM PENTOXIDE                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Heart                                  Cardiomyopathy                                                                               
Islets, Pancreatic                     Hyperplasia                                                                                  
Kidney                                 Nephropathy                                                                                  
Larynx: Respiratory Epithelium, Epiglottis                                                                                          
                                       Metaplasia                                                                                   
Liver                                  Clear Cell Focus                                                                             
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Lung: Bronchiole, Epithelium           Hyperplasia                                                                                  
Lung: Interstitium                     Fibrosis                                                                                     
Lymph Node, Bronchial                  Hyperplasia                                                                                  
Lymph Node, Mediastinal                Hyperplasia                                                                                  
Nose                                   Inflammation                                                                                 
Nose: Olfactory Epithelium             Atrophy                                                                                      
                                       Degeneration Hyaline                                                                         
Nose: Respiratory Epithelium           Degeneration Hyaline                                                                         
                                       Metaplasia                                                                                   
                                       Necrosis                                                                                     
Preputial Gland                        Ectasia                                                                                      
Prostate                               Inflammation                                                                                 
Skin: Prepuce                          Inflammation Chronic                                                                         
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Medulla                        Hyperplasia                                                                                  
Bone                                   Fibrous Osteodystrophy                                                                       
Kidney                                 Nephropathy                                                                                  
Larynx: Respiratory Epithelium, Epiglottis                                                                                          
                                       Metaplasia                                                                                   
Liver                                  Eosinophilic Focus                                                                           
                                       Inflammation Focal Granulomatous                                                             
                                       Necrosis Focal                                                                               
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Lung: Bronchiole, Epithelium           Hyperplasia                                                                                  
Lung: Interstitium                     Fibrosis                                                                                     
Lymph Node                             Angiectasis                                                                                  
Lymph Node, Bronchial                  Hyperplasia                                                                                  
Nose                                   Inflammation                                                                                 
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:33:42       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
Nose: Olfactory Epithelium             Atrophy                                                                                      
                                       Degeneration Hyaline                                                                         
Nose: Respiratory Epithelium           Degeneration Hyaline                                                                         
                                       Metaplasia                                                                                   
                                       Necrosis                                                                                     
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Cyst                                                                                         
Thyroid Gland                          Inflammation                                                                                 
Uterus                                 Angiectasis                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                 VANADIUM PENTOXIDE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/43.43      0/45.85      0/40.35     |0/45.55      0/41.52      2/40.00      2/42.50      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         0.0%         5.0%         4.7%         | 
|TERMINAL (d)       |     0/39 (0%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    1/30 (3%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          705          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617N     P=0.467      (e)          (e)         |P=0.076      (e)          P=0.197      P=0.206      | 
|POLY 3             |     P=0.576N     P=0.485      (e)          (e)         |P=0.080      (e)          P=0.209      P=0.222      | 
|POLY 1.5           |     P=0.573N     P=0.489      (e)          (e)         |P=0.084      (e)          P=0.218      P=0.229      | 
|POLY 6             |     P=0.579N     P=0.480      (e)          (e)         |P=0.076      (e)          P=0.202      P=0.215      | 
|LOGISTIC REGRESSION|     (e)          P=0.467      (e)          (e)         |P=0.078      (e)          P=0.204      P=0.208      | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.083      (e)          P=0.242      P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   0/49 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     9/46.78      0/43.43      2/45.90      0/40.35     |0/45.55      0/41.52      0/39.90      0/42.48      | 
|POLY-3 PERCENT (g) |     19.2%        0.0%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     9/39 (23%)   0/33 (0%)    1/36 (3%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          718          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003N**   P=0.005N**   P=0.037N*    P=0.011N*   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001N**   P=0.002N**   P=0.027N*    P=0.004N**  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001N**   P=0.002N**   P=0.026N*    P=0.003N**  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001N**   P=0.003N**   P=0.028N*    P=0.006N**  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.003N**   (e)          P=0.034N*    (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001N**   P<0.001N**   P=0.026N*    P<0.001N**  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     40/50 (80%)  36/49 (73%)  31/50 (62%)  31/50 (62%) |5/50 (10%)   5/50 (10%)   3/49 (6%)    7/49 (14%)   | 
|POLY-3 RATE (b)    |     40/47.73     36/46.09     31/47.94     31/45.10    |5/45.73      5/41.95      3/40.16      7/43.39      | 
|POLY-3 PERCENT (g) |     83.8%        78.1%        64.7%        68.7%       |10.9%        11.9%        7.5%         16.1%        | 
|TERMINAL (d)       |     34/39 (87%)  29/33 (88%)  25/36 (69%)  19/27 (70%) |4/38 (11%)   4/32 (13%)   2/30 (7%)    5/31 (16%)   | 
|FIRST INCIDENCE    |     620          514          422          387         |686          603          662          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.450      P=0.423      P=0.140N     P=0.360     |P=0.233      P=0.522      P=0.485N     P=0.271      | 
|POLY 3             |     P=0.035N*    P=0.321N     P=0.022N*    P=0.058N    |P=0.289      P=0.575      P=0.430N     P=0.342      | 
|POLY 1.5           |     P=0.028N*    P=0.312N     P=0.027N*    P=0.046N*   |P=0.302      P=0.591      P=0.405N     P=0.358      | 
|POLY 6             |     P=0.049N*    P=0.336N     P=0.020N*    P=0.087N    |P=0.276      P=0.556      P=0.450N     P=0.325      | 
|LOGISTIC REGRESSION|     P=0.088N     P=0.486N     P=0.045N*    P=0.157N    |P=0.292      P=0.576      P=0.435N     P=0.353      | 
|COCH-ARM / FISHERS |     P=0.024N*    P=0.298N     P=0.038N*    P=0.038N*   |P=0.302      P=0.630N     P=0.369N     P=0.365      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/49 (2%)    1/50 (2%)   |4/49 (8%)    0/50 (0%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      2/44.04      1/44.85      1/40.35     |4/45.58      0/41.52      0/39.39      0/42.48      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.2%         2.5%        |8.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/33 (3%)    1/35 (3%)    1/27 (4%)   |2/38 (5%)    0/32 (0%)    0/30 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          530          729 (T)      729 (T)     |683          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.426      P=0.221      P=0.478      P=0.427     |P=0.028N*    P=0.092N     P=0.097N     P=0.086N     | 
|POLY 3             |     P=0.434      P=0.224      P=0.492      P=0.471     |P=0.017N*    P=0.073N     P=0.081N     P=0.070N     | 
|POLY 1.5           |     P=0.462      P=0.227      P=0.493      P=0.483     |P=0.017N*    P=0.068N     P=0.074N     P=0.064N     | 
|POLY 6             |     P=0.398      P=0.220      P=0.489      P=0.455     |P=0.016N*    P=0.080N     P=0.088N     P=0.076N     | 
|LOGISTIC REGRESSION|     P=0.533      P=0.298      P=0.478      P=0.427     |P=0.023N*    P=0.068N     P=0.074N     P=0.065N     | 
|COCH-ARM / FISHERS |     P=0.501      P=0.242      P=0.495      P=0.500     |P=0.021N*    P=0.056N     P=0.061N     P=0.059N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fibrous Osteodystrophy                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    2/50 (4%)   |28/50 (56%)  21/50 (42%)  22/50 (44%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     1/46.78      3/44.23      2/45.85      2/40.35     |28/46.13     21/42.32     22/41.17     32/45.20     | 
|POLY-3 PERCENT (g) |     2.1%         6.8%         4.4%         5.0%        |60.7%        49.6%        53.4%        70.8%        | 
|TERMINAL (d)       |     1/39 (3%)    2/33 (6%)    2/36 (6%)    2/27 (7%)   |25/38 (66%)  19/32 (59%)  16/30 (53%)  25/32 (78%)  | 
|FIRST INCIDENCE    |     729 (T)      695          729 (T)      729 (T)     |626          564          584          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.362      P=0.253      P=0.472      P=0.372     |P=0.031 *    P=0.342N     P=0.550N     P=0.059      | 
|POLY 3             |     P=0.425      P=0.286      P=0.493      P=0.449     |P=0.102      P=0.198N     P=0.317N     P=0.206      | 
|POLY 1.5           |     P=0.456      P=0.293      P=0.496      P=0.470     |P=0.125      P=0.169N     P=0.249N     P=0.251      | 
|POLY 6             |     P=0.386      P=0.276      P=0.489      P=0.421     |P=0.082      P=0.241N     P=0.363N     P=0.160      | 
|LOGISTIC REGRESSION|     P=0.374      P=0.272      P=0.472      P=0.372     |P=0.063      P=0.282N     P=0.423N     P=0.129      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.309      P=0.500      P=0.500     |P=0.131      P=0.115N     P=0.159N     P=0.270      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fracture                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      1/46.66      0/40.35     |0/45.55      0/41.52      3/42.44      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |0.0%         0.0%         7.1%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          422          ---         |---          ---          251          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.690      (e)          P=0.500      (e)         |P=0.548      (e)          P=0.119      (e)          | 
|POLY 3             |     P=0.631      (e)          P=0.499      (e)         |P=0.529      (e)          P=0.106      (e)          | 
|POLY 1.5           |     P=0.658      (e)          P=0.500      (e)         |P=0.542      (e)          P=0.112      (e)          | 
|POLY 6             |     P=0.592      (e)          P=0.498      (e)         |P=0.514      (e)          P=0.102      (e)          | 
|LOGISTIC REGRESSION|     P=0.546N     (e)          (e)          (e)         |P=0.380      (e)          P=0.103      (e)          | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.539      (e)          P=0.121      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   4/50 (8%)    4/50 (8%)   |5/50 (10%)   1/50 (2%)    6/50 (12%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     8/47.53      5/45.98      4/46.18      4/41.19     |5/45.74      1/41.78      6/41.62      6/44.25      | 
|POLY-3 PERCENT (g) |     16.8%        10.9%        8.7%         9.7%        |10.9%        2.4%         14.4%        13.6%        | 
|TERMINAL (d)       |     6/39 (15%)   2/33 (6%)    2/36 (6%)    3/27 (11%)  |4/38 (11%)   0/32 (0%)    3/30 (10%)   4/32 (13%)   | 
|FIRST INCIDENCE    |     499          405          653          394         |681          660          318          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.274N     P=0.361N     P=0.220N     P=0.366N    |P=0.184      P=0.153N     P=0.363      P=0.406      | 
|POLY 3             |     P=0.193N     P=0.298N     P=0.191N     P=0.254N    |P=0.227      P=0.123N     P=0.434      P=0.477      | 
|POLY 1.5           |     P=0.173N     P=0.289N     P=0.186N     P=0.219N    |P=0.235      P=0.117N     P=0.459      P=0.493      | 
|POLY 6             |     P=0.219N     P=0.310N     P=0.197N     P=0.304N    |P=0.219      P=0.132N     P=0.416      P=0.458      | 
|LOGISTIC REGRESSION|     P=0.075N     P=0.159N     P=0.172N     P=0.138N    |P=0.227      P=0.120N     P=0.505      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.146N     P=0.277N     P=0.178N     P=0.178N    |P=0.226      P=0.102N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/43.10      0/45.85      0/40.35     |2/46.22      0/41.52      2/41.48      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.3%         0.0%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/32 (0%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |505          ---          318          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.258N     P=0.263N     P=0.646      P=0.259N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.246N     P=0.262N     P=0.654      P=0.251N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.254N     P=0.670      P=0.243N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.250N     P=0.271N     P=0.642      P=0.260N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.278N     P=0.218N     P=0.653N     P=0.248N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.247N     P=0.691N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Meninges                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/43.10      0/45.85      0/40.35     |0/45.55      2/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/32 (3%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    2/32 (6%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.615N     P=0.461      (e)          (e)         |P=0.437N     P=0.201      (e)          (e)          | 
|POLY 3             |     P=0.577N     P=0.484      (e)          (e)         |P=0.434N     P=0.217      (e)          (e)          | 
|POLY 1.5           |     P=0.573N     P=0.489      (e)          (e)         |P=0.422N     P=0.223      (e)          (e)          | 
|POLY 6             |     P=0.580N     P=0.478      (e)          (e)         |P=0.447N     P=0.210      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.461      (e)          (e)         |(e)          P=0.201      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     3/46.78      0/44.10      1/45.85      0/40.35     |                                                    | 
|POLY-3 PERCENT (g) |     6.4%         0.0%         2.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     3/39 (8%)    0/33 (0%)    1/36 (3%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.119N     P=0.152N     P=0.334N     P=0.193N    |                                                    | 
|POLY 3             |     P=0.087N     P=0.130N     P=0.313N     P=0.148N    |                                                    | 
|POLY 1.5           |     P=0.086N     P=0.125N     P=0.310N     P=0.135N    |                                                    | 
|POLY 6             |     P=0.089N     P=0.135N     P=0.317N     P=0.165N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.119N     (e)          P=0.334N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.121N     P=0.309N     P=0.121N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/47.55      0/44.10      0/45.85      0/40.20     |0/45.55      0/41.52      0/39.96      0/43.06      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     523          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.130N     P=0.258N     P=0.245N     P=0.290N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.105N     P=0.254N     P=0.245N     P=0.276N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.109N     P=0.247N     P=0.242N     P=0.261N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.100N     P=0.263N     P=0.250N     P=0.298N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.074N     P=0.135N     P=0.175N     P=0.110N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.247N     P=0.253N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  48/50 (96%)  48/50 (96%)  47/50 (94%) |47/50 (94%)  45/50 (90%)  46/50 (92%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     48/48.69     48/49.23     48/49.16     47/48.88    |47/47.35     45/45.94     46/46.87     49/49.04     | 
|POLY-3 PERCENT (g) |     98.6%        97.5%        97.6%        96.2%       |99.3%        98.0%        98.1%        99.9%        | 
|TERMINAL (d)       |     39/39 (100%) 33/33 (100%) 36/36 (100%) 26/27 (96%) |38/38 (100%) 32/32 (100%) 30/30 (100%) 32/32 (100%) | 
|FIRST INCIDENCE    |     603          405          422          387         |626          446          270          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.106      P=0.299      P=0.008 **  |P=0.058      P=0.164      P=0.055      P=0.056      | 
|POLY 3             |     P=0.297N     P=0.680N     P=0.710N     P=0.443N    |P=0.488      P=0.693N     P=0.727N     P=0.980      | 
|POLY 1.5           |     P=0.338N     P=0.671N     P=0.685N     P=0.464N    |P=0.410      P=0.600N     P=0.550N     P=0.783      | 
|POLY 6             |     P=0.246N     P=0.803N     P=0.864N     P=0.445N    |P=0.740      P=0.959N     P=0.895N     P=1.000      | 
|LOGISTIC REGRESSION|     P=0.482      P=0.462      P=0.657      P=0.520     |P=0.163      P=0.685      P=0.488      P=0.257      | 
|COCH-ARM / FISHERS |     P=0.387N     P=0.691N     P=0.691N     P=0.500N    |P=0.178      P=0.357N     P=0.500N     P=0.309      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.43      0/45.85      0/40.35     |2/47.21      1/42.52      1/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |4.2%         2.4%         2.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          639          ---          ---         |181          23           731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.590N     P=0.486      (e)          (e)         |P=0.162N     P=0.507N     P=0.540N     P=0.238N     | 
|POLY 3             |     P=0.577N     P=0.490      (e)          (e)         |P=0.163N     P=0.536N     P=0.558N     P=0.256N     | 
|POLY 1.5           |     P=0.574N     P=0.494      (e)          (e)         |P=0.158N     P=0.525N     P=0.538N     P=0.247N     | 
|POLY 6             |     P=0.580N     P=0.485      (e)          (e)         |P=0.168N     P=0.550N     P=0.573N     P=0.265N     | 
|LOGISTIC REGRESSION|     P=0.511N     P=0.559      (e)          (e)         |P=0.215N     P=0.291N     P=0.460N     P=0.369N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.153N     P=0.500N     P=0.500N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Capillary                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.78      0/44.10      0/45.85      0/40.35     |2/45.55      0/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |2/38 (5%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.342N     P=0.533N     P=0.516N     P=0.573N    |P=0.135N     P=0.277N     P=0.292N     P=0.277N     | 
|POLY 3             |     P=0.284N     P=0.512N     P=0.504N     P=0.529N    |P=0.109N     P=0.258N     P=0.268N     P=0.248N     | 
|POLY 1.5           |     P=0.294N     P=0.507N     P=0.502N     P=0.517N    |P=0.110N     P=0.252N     P=0.256N     P=0.241N     | 
|POLY 6             |     P=0.272N     P=0.517N     P=0.506N     P=0.545N    |P=0.108N     P=0.266N     P=0.277N     P=0.255N     | 
|LOGISTIC REGRESSION|     P=0.342N     (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  6/50 (12%)   1/50 (2%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     11/47.03     6/45.73      1/45.85      2/40.69     |0/45.55      1/41.54      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     23.4%        13.1%        2.2%         4.9%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     9/39 (23%)   3/33 (9%)    1/36 (3%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     667          530          729 (T)      676         |---          726          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008N**   P=0.235N     P=0.005N**   P=0.047N*   |P=0.580N     P=0.472      (e)          (e)          | 
|POLY 3             |     P=0.002N**   P=0.156N     P=0.002N**   P=0.015N*   |P=0.586N     P=0.482      (e)          (e)          | 
|POLY 1.5           |     P=0.002N**   P=0.151N     P=0.002N**   P=0.011N*   |P=0.579N     P=0.487      (e)          (e)          | 
|POLY 6             |     P=0.003N**   P=0.163N     P=0.002N**   P=0.022N*   |P=0.594N     P=0.475      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.127N     P=0.003N**   P=0.023N*   |P=0.577N     P=0.470      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.002N**   P=0.143N     P=0.002N**   P=0.007N**  |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      0/45.85      1/40.83     |2/45.76      1/42.13      0/39.90      1/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.5%        |4.4%         2.4%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          586         |695          530          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      (e)          (e)          P=0.469     |P=0.389N     P=0.539N     P=0.283N     P=0.541N     | 
|POLY 3             |     P=0.184      (e)          (e)          P=0.473     |P=0.373N     P=0.529N     P=0.269N     P=0.518N     | 
|POLY 1.5           |     P=0.190      (e)          (e)          P=0.484     |P=0.369N     P=0.521N     P=0.258N     P=0.507N     | 
|POLY 6             |     P=0.177      (e)          (e)          P=0.459     |P=0.378N     P=0.540N     P=0.279N     P=0.531N     | 
|LOGISTIC REGRESSION|     P=0.282      (e)          (e)          P=0.656     |P=0.368N     P=0.486N     P=0.256N     P=0.514N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.367N     P=0.500N     P=0.253N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    7/50 (14%)   6/50 (12%)  |1/50 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.78      3/44.10      7/45.85      6/41.08     |1/45.55      1/41.52      0/39.90      1/43.48      | 
|POLY-3 PERCENT (g) |     10.7%        6.8%         15.3%        14.6%       |2.2%         2.4%         0.0%         2.3%         | 
|TERMINAL (d)       |     5/39 (13%)   3/33 (9%)    7/36 (19%)   3/27 (11%)  |1/38 (3%)    1/32 (3%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      654         |731 (T)      731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.138      P=0.450N     P=0.322      P=0.278     |P=0.651      P=0.723      P=0.547N     P=0.723      | 
|POLY 3             |     P=0.234      P=0.389N     P=0.365      P=0.410     |P=0.624N     P=0.740      P=0.526N     P=0.750      | 
|POLY 1.5           |     P=0.262      P=0.376N     P=0.371      P=0.446     |P=0.619N     P=0.746      P=0.518N     P=0.757      | 
|POLY 6             |     P=0.203      P=0.405N     P=0.356      P=0.367     |P=0.628N     P=0.732      P=0.534N     P=0.743      | 
|LOGISTIC REGRESSION|     P=0.170      P=0.450N     P=0.322      P=0.371     |P=0.651      P=0.723      (e)          P=0.723      | 
|COCH-ARM / FISHERS |     P=0.306      P=0.357N     P=0.380      P=0.500     |P=0.616N     P=0.753N     P=0.505N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      2/44.58      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          590          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.456N     P=0.218      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.433N     P=0.227      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.422N     P=0.231      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.447N     P=0.222      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.354N     P=0.274      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct Chronic                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      2/45.85      0/40.35     |0/45.55      0/41.52      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    2/36 (6%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.531      (e)          P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.516      (e)          P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.550      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.470      (e)          P=0.230      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    7/50 (14%)   7/50 (14%)   1/50 (2%)   |3/50 (6%)    3/50 (6%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.78      7/44.57      7/45.85      1/40.35     |3/45.55      3/41.78      1/39.90      2/43.65      | 
|POLY-3 PERCENT (g) |     4.3%         15.7%        15.3%        2.5%        |6.6%         7.2%         2.5%         4.6%         | 
|TERMINAL (d)       |     2/39 (5%)    6/33 (18%)   7/36 (19%)   1/27 (4%)   |3/38 (8%)    2/32 (6%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      590          729 (T)      729 (T)     |731 (T)      660          731 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.436N     P=0.050      P=0.062      P=0.628N    |P=0.403N     P=0.581      P=0.393N     P=0.567N     | 
|POLY 3             |     P=0.376N     P=0.068      P=0.074      P=0.551N    |P=0.359N     P=0.622      P=0.354N     P=0.519N     | 
|POLY 1.5           |     P=0.324N     P=0.072      P=0.076      P=0.530N    |P=0.349N     P=0.633      P=0.338N     P=0.507N     | 
|POLY 6             |     P=0.446N     P=0.062      P=0.071      P=0.578N    |P=0.370N     P=0.608      P=0.368N     P=0.533N     | 
|LOGISTIC REGRESSION|     P=0.391N     P=0.067      P=0.062      P=0.628N    |P=0.367N     P=0.611      P=0.393N     P=0.537N     | 
|COCH-ARM / FISHERS |     P=0.260N     P=0.080      P=0.080      P=0.500N    |P=0.345N     P=0.661N     P=0.316N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  50/50 (100%) 48/50 (96%)  48/50 (96%) |43/50 (86%)  33/50 (66%)  43/49 (88%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     48/48.98     50/50.00     48/49.59     48/48.57    |43/47.63     33/43.47     43/45.16     39/48.55     | 
|POLY-3 PERCENT (g) |     98.0%        100.0%       96.8%        98.8%       |90.3%        75.9%        95.2%        80.3%        | 
|TERMINAL (d)       |     39/39 (100%) 33/33 (100%) 35/36 (97%)  27/27 (100%)|35/38 (92%)  27/32 (84%)  30/30 (100%) 25/32 (78%)  | 
|FIRST INCIDENCE    |     499          405          422          394         |505          522          270          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   P=0.055      P=0.312      P=0.004 **  |P=0.224      P=0.278N     P=0.044 *    P=0.430      | 
|POLY 3             |     P=0.679      P=0.503      P=0.618N     P=0.755     |P=0.234N     P=0.047N*    P=0.291      P=0.131N     | 
|POLY 1.5           |     P=0.595N     P=0.343      P=0.655N     P=0.698     |P=0.257N     P=0.031N*    P=0.408      P=0.125N     | 
|POLY 6             |     P=0.704      P=0.881      P=0.564N     P=0.938     |P=0.202N     P=0.090N     P=0.213      P=0.142N     | 
|LOGISTIC REGRESSION|     P=0.470      P=0.098      P=0.641      P=0.215     |P=0.461N     P=0.054N     P=0.242      P=0.208N     | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.247      P=0.691N     P=0.691N    |P=0.486N     P=0.017N*    P=0.516      P=0.218N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.78      0/44.10      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141N     P=0.276N     P=0.256N     P=0.322N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.104N     P=0.251N     P=0.242N     P=0.272N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.108N     P=0.245N     P=0.240N     P=0.257N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.099N     P=0.257N     P=0.244N     P=0.292N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.141N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   7/50 (14%)   2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.78      7/44.10      2/45.90      4/40.96     |0/45.55      0/41.52      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     10.7%        15.9%        4.4%         9.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/39 (13%)   7/33 (21%)   1/36 (3%)    2/27 (7%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      718          573         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.466N     P=0.264      P=0.250N     P=0.566     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.334N     P=0.338      P=0.224N     P=0.583N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.312N     P=0.355      P=0.221N     P=0.549N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.362N     P=0.318      P=0.228N     P=0.625N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.402N     P=0.264      P=0.241N     P=0.604N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.279N     P=0.380      P=0.218N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.16      2/44.98      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |     2.1%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     620          558          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.211N     P=0.477      P=0.509N     P=0.542N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.205N     P=0.483      P=0.506N     P=0.531N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.198N     P=0.490      P=0.503N     P=0.518N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.214N     P=0.476      P=0.509N     P=0.548N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.098N     P=0.659      P=0.455N     P=0.397N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    3/49 (6%)    0/50 (0%)   |3/50 (6%)    2/50 (4%)    3/49 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.31      0/44.10      3/45.59      0/40.35     |3/46.54      2/42.01      3/39.63      1/43.62      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         6.6%         0.0%        |6.5%         4.8%         7.6%         2.3%         | 
|TERMINAL (d)       |     1/39 (3%)    0/33 (0%)    2/36 (6%)    0/27 (0%)   |2/38 (5%)    0/32 (0%)    3/30 (10%)   0/32 (0%)    | 
|FIRST INCIDENCE    |     692          ---          639          ---         |181          603          731 (T)      695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.275N     P=0.474      P=0.329N    |P=0.308N     P=0.554N     P=0.571      P=0.344N     | 
|POLY 3             |     P=0.337N     P=0.248N     P=0.493      P=0.269N    |P=0.281N     P=0.546N     P=0.586      P=0.329N     | 
|POLY 1.5           |     P=0.317N     P=0.242N     P=0.496      P=0.254N    |P=0.271N     P=0.535N     P=0.608      P=0.318N     | 
|POLY 6             |     P=0.364N     P=0.257N     P=0.489      P=0.291N    |P=0.292N     P=0.559N     P=0.570      P=0.340N     | 
|LOGISTIC REGRESSION|     P=0.310N     P=0.241N     P=0.505      P=0.268N    |P=0.267N     P=0.449N     P=0.649N     P=0.337N     | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.242N     P=0.500      P=0.242N    |P=0.264N     P=0.500N     P=0.651      P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Respiratory Epithelium, Epiglottis                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    45/50 (90%)  41/49 (84%)  41/50 (82%) |0/50 (0%)    39/50 (78%)  45/49 (92%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     2/46.16      45/49.91     41/47.00     41/47.66    |0/45.55      39/47.47     45/48.49     44/49.71     | 
|POLY-3 PERCENT (g) |     4.3%         90.2%        87.2%        86.0%       |0.0%         82.2%        92.8%        88.5%        | 
|TERMINAL (d)       |     2/39 (5%)    30/33 (91%)  34/36 (94%)  22/27 (82%) |0/38 (0%)    25/32 (78%)  27/30 (90%)  27/32 (84%)  | 
|FIRST INCIDENCE    |     729 (T)      405          606          387         |---          23           251          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Squamous Epithelium                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   4/50 (8%)    11/49 (22%)  5/50 (10%)  |15/50 (30%)  10/50 (20%)  17/49 (35%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     5/46.16      4/44.81      11/45.59     5/40.35     |15/47.49     10/43.56     17/43.97     14/46.13     | 
|POLY-3 PERCENT (g) |     10.8%        8.9%         24.1%        12.4%       |31.6%        23.0%        38.7%        30.4%        | 
|TERMINAL (d)       |     5/39 (13%)   2/33 (6%)    10/36 (28%)  5/27 (19%)  |11/38 (29%)  4/32 (13%)   8/30 (27%)   8/32 (25%)   | 
|FIRST INCIDENCE    |     729 (T)      514          639          729 (T)     |181          23           251          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210      P=0.585N     P=0.061      P=0.388     |P=0.344      P=0.323N     P=0.215      P=0.509      | 
|POLY 3             |     P=0.298      P=0.519N     P=0.079      P=0.544     |P=0.452      P=0.246N     P=0.313      P=0.537N     | 
|POLY 1.5           |     P=0.354      P=0.506N     P=0.081      P=0.586     |P=0.469      P=0.225N     P=0.333      P=0.513N     | 
|POLY 6             |     P=0.231      P=0.535N     P=0.075      P=0.487     |P=0.434      P=0.268N     P=0.313      P=0.563N     | 
|LOGISTIC REGRESSION|     P=0.289      P=0.492N     P=0.072      P=0.388     |P=0.445      P=0.158N     P=0.432      P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.439      P=0.487N     P=0.085      P=0.617N    |P=0.455      P=0.178N     P=0.388      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.85      0/44.10      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.96      1/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/39 (3%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     710          ---          ---          ---         |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.143N     P=0.270N     P=0.257N     P=0.329N    |P=0.187      (e)          (e)          P=0.466      | 
|POLY 3             |     P=0.104N     P=0.251N     P=0.242N     P=0.272N    |P=0.197      (e)          (e)          P=0.491      | 
|POLY 1.5           |     P=0.108N     P=0.245N     P=0.240N     P=0.257N    |P=0.200      (e)          (e)          P=0.497      | 
|POLY 6             |     P=0.099N     P=0.258N     P=0.245N     P=0.292N    |P=0.194      (e)          (e)          P=0.484      | 
|LOGISTIC REGRESSION|     P=0.130N     P=0.256N     P=0.243N     P=0.295N    |(e)          (e)          (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.198      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.78      3/44.10      0/45.85      0/40.35     |1/45.55      0/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     8.6%         6.8%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/39 (10%)   3/33 (9%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028N*    P=0.591N     P=0.073N     P=0.118N    |P=0.328N     P=0.534N     P=0.547N     P=0.534N     | 
|POLY 3             |     P=0.017N*    P=0.532N     P=0.063N     P=0.082N    |P=0.301N     P=0.518N     P=0.526N     P=0.509N     | 
|POLY 1.5           |     P=0.017N*    P=0.519N     P=0.062N     P=0.072N    |P=0.303N     P=0.513N     P=0.517N     P=0.503N     | 
|POLY 6             |     P=0.019N*    P=0.548N     P=0.064N     P=0.095N    |P=0.298N     P=0.525N     P=0.534N     P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.028N*    P=0.591N     (e)          (e)         |P=0.328N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.016N*    P=0.500N     P=0.059N     P=0.059N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  16/50 (32%)  19/50 (38%)  19/50 (38%) |16/50 (32%)  14/50 (28%)  4/50 (8%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     20/47.84     16/44.71     19/47.21     19/44.03    |16/46.59     14/42.91     4/41.83      8/43.92      | 
|POLY-3 PERCENT (g) |     41.8%        35.8%        40.2%        43.2%       |34.3%        32.6%        9.6%         18.2%        | 
|TERMINAL (d)       |     18/39 (46%)  15/33 (46%)  15/36 (42%)  9/27 (33%)  |13/38 (34%)  11/32 (34%)  1/30 (3%)    6/32 (19%)   | 
|FIRST INCIDENCE    |     499          534          534          494         |505          522          318          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.142      P=0.484N     P=0.548      P=0.217     |P=0.039N*    P=0.549      P=0.015N*    P=0.117N     | 
|POLY 3             |     P=0.422      P=0.351N     P=0.521N     P=0.532     |P=0.016N*    P=0.521N     P=0.005N**   P=0.065N     | 
|POLY 1.5           |     P=0.458      P=0.316N     P=0.514N     P=0.581     |P=0.014N*    P=0.491N     P=0.003N**   P=0.054N     | 
|POLY 6             |     P=0.387      P=0.398N     P=0.529N     P=0.480     |P=0.020N*    P=0.558N     P=0.006N**   P=0.078N     | 
|LOGISTIC REGRESSION|     P=0.421      P=0.341N     P=0.510N     P=0.539N    |P=0.016N*    P=0.491N     P=0.003N**   P=0.059N     | 
|COCH-ARM / FISHERS |     P=0.520      P=0.266N     P=0.500N     P=0.500N    |P=0.015N*    P=0.414N     P=0.003N**   P=0.050N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    6/50 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.10      0/45.85      0/40.35     |4/46.14      0/41.52      6/42.73      3/44.16      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |8.7%         0.0%         14.0%        6.8%         | 
|TERMINAL (d)       |     0/39 (0%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |662          ---          270          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617N     P=0.467      (e)          (e)         |P=0.444      P=0.095N     P=0.282      P=0.557N     | 
|POLY 3             |     P=0.578N     P=0.488      (e)          (e)         |P=0.486      P=0.075N     P=0.322      P=0.524N     | 
|POLY 1.5           |     P=0.574N     P=0.493      (e)          (e)         |P=0.496      P=0.070N     P=0.341      P=0.508N     | 
|POLY 6             |     P=0.581N     P=0.483      (e)          (e)         |P=0.475      P=0.082N     P=0.308      P=0.543N     | 
|LOGISTIC REGRESSION|     (e)          P=0.467      (e)          (e)         |P=0.460      P=0.066N     P=0.430      P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.481      P=0.059N     P=0.370      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Focal Granulomatous                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   7/50 (14%)   3/50 (6%)   |12/50 (24%)  26/50 (52%)  19/50 (38%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     2/47.46      6/44.16      7/45.85      3/40.83     |12/45.64     26/41.88     19/40.59     21/44.19     | 
|POLY-3 PERCENT (g) |     4.2%         13.6%        15.3%        7.4%        |26.3%        62.1%        46.8%        47.5%        | 
|TERMINAL (d)       |     1/39 (3%)    5/33 (15%)   7/36 (19%)   2/27 (7%)   |11/38 (29%)  24/32 (75%)  17/30 (57%)  17/32 (53%)  | 
|FIRST INCIDENCE    |     499          714          729 (T)      586         |709          635          584          612          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340      P=0.098      P=0.066      P=0.383     |P=0.044 *    P<0.001 **   P=0.015 *    P=0.012 *    | 
|POLY 3             |     P=0.400      P=0.111      P=0.071      P=0.432     |P=0.099      P<0.001 **   P=0.036 *    P=0.028 *    | 
|POLY 1.5           |     P=0.454      P=0.120      P=0.074      P=0.460     |P=0.128      P<0.001 **   P=0.053      P=0.036 *    | 
|POLY 6             |     P=0.335      P=0.101      P=0.067      P=0.398     |P=0.075      P<0.001 **   P=0.027 *    P=0.021 *    | 
|LOGISTIC REGRESSION|     P=0.460      P=0.136      P=0.082      P=0.617     |P=0.077      P<0.001 **   P=0.022 *    P=0.017 *    | 
|COCH-ARM / FISHERS |     P=0.533      P=0.134      P=0.080      P=0.500     |P=0.152      P=0.004 **   P=0.097      P=0.044 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   3/50 (6%)    5/50 (10%)   4/50 (8%)   |2/50 (4%)    6/50 (12%)   9/50 (18%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     8/46.87      3/44.16      5/47.15      4/41.48     |2/45.74      6/43.38      9/43.00      5/45.02      | 
|POLY-3 PERCENT (g) |     17.1%        6.8%         10.6%        9.6%        |4.4%         13.8%        20.9%        11.1%        | 
|TERMINAL (d)       |     6/39 (15%)   2/33 (6%)    2/36 (6%)    1/27 (4%)   |1/38 (3%)    1/32 (3%)    4/30 (13%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     710          714          534          573         |683          446          270          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.374N     P=0.160N     P=0.326N     P=0.383N    |P=0.214      P=0.103      P=0.016 *    P=0.182      | 
|POLY 3             |     P=0.249N     P=0.118N     P=0.272N     P=0.241N    |P=0.236      P=0.116      P=0.019 *    P=0.210      | 
|POLY 1.5           |     P=0.234N     P=0.110N     P=0.274N     P=0.214N    |P=0.254      P=0.120      P=0.021 *    P=0.218      | 
|POLY 6             |     P=0.267N     P=0.128N     P=0.270N     P=0.278N    |P=0.215      P=0.112      P=0.017 *    P=0.198      | 
|LOGISTIC REGRESSION|     P=0.199N     P=0.138N     P=0.263N     P=0.211N    |P=0.218      P=0.143      P=0.037 *    P=0.199      | 
|COCH-ARM / FISHERS |     P=0.213N     P=0.100N     P=0.277N     P=0.178N    |P=0.246      P=0.134      P=0.026 *    P=0.218      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation Hemosiderin                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      3/46.03      1/40.35     |1/45.73      0/41.52      2/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.5%         2.5%        |2.2%         0.0%         5.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    1/36 (3%)    1/27 (4%)   |0/38 (0%)    0/32 (0%)    2/30 (7%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          695          729 (T)     |686          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.168      (e)          P=0.115      P=0.427     |P=0.491N     P=0.536N     P=0.424      P=0.515N     | 
|POLY 3             |     P=0.186      (e)          P=0.116      P=0.471     |P=0.461N     P=0.519N     P=0.453      P=0.510N     | 
|POLY 1.5           |     P=0.210      (e)          P=0.117      P=0.483     |P=0.456N     P=0.513N     P=0.470      P=0.504N     | 
|POLY 6             |     P=0.157      (e)          P=0.114      P=0.455     |P=0.468N     P=0.527N     P=0.439      P=0.517N     | 
|LOGISTIC REGRESSION|     P=0.192      (e)          P=0.118      P=0.427     |P=0.473N     P=0.504N     P=0.451      P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.461N     P=0.500N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    2/50 (4%)    3/50 (6%)   |2/50 (4%)    4/50 (8%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.78      4/44.10      2/46.66      3/40.48     |2/45.74      4/42.20      1/40.57      2/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         9.1%         4.3%         7.4%        |4.4%         9.5%         2.5%         4.6%         | 
|TERMINAL (d)       |     2/39 (5%)    4/33 (12%)   1/36 (3%)    2/27 (7%)   |1/38 (3%)    2/32 (6%)    0/30 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      422          695         |681          522          534          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.262      P=0.672      P=0.335     |P=0.475N     P=0.277      P=0.566N     P=0.635      | 
|POLY 3             |     P=0.450      P=0.310      P=0.693      P=0.435     |P=0.459N     P=0.301      P=0.542N     P=0.676      | 
|POLY 1.5           |     P=0.479      P=0.321      P=0.694N     P=0.462     |P=0.444N     P=0.311      P=0.527N     P=0.687      | 
|POLY 6             |     P=0.415      P=0.297      P=0.690      P=0.401     |P=0.477N     P=0.288      P=0.554N     P=0.662      | 
|LOGISTIC REGRESSION|     P=0.503      P=0.262      P=0.658N     P=0.363     |P=0.431N     P=0.326      P=0.485N     P=0.674      | 
|COCH-ARM / FISHERS |     P=0.521      P=0.339      P=0.691N     P=0.500     |P=0.431N     P=0.339      P=0.500N     P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |4/50 (8%)    3/50 (6%)    4/50 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/46.85      3/44.10      3/45.85      1/40.35     |4/45.55      3/41.52      4/40.29      4/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         6.8%         6.5%         2.5%        |8.8%         7.2%         9.9%         9.2%         | 
|TERMINAL (d)       |     1/39 (3%)    3/33 (9%)    3/36 (8%)    1/27 (4%)   |4/38 (11%)   3/32 (9%)    2/30 (7%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     710          729 (T)      729 (T)      729 (T)     |731 (T)      731 (T)      646          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.484N     P=0.430      P=0.464      P=0.632N    |P=0.434      P=0.594N     P=0.516      P=0.547      | 
|POLY 3             |     P=0.411N     P=0.472      P=0.490      P=0.552N    |P=0.502      P=0.550N     P=0.574      P=0.618      | 
|POLY 1.5           |     P=0.383N     P=0.484      P=0.494      P=0.530N    |P=0.518      P=0.536N     P=0.599      P=0.634      | 
|POLY 6             |     P=0.449N     P=0.459      P=0.484      P=0.580N    |P=0.485      P=0.569N     P=0.556      P=0.599      | 
|LOGISTIC REGRESSION|     P=0.482N     P=0.448      P=0.477      P=0.608N    |P=0.474      P=0.594N     P=0.556      P=0.547      | 
|COCH-ARM / FISHERS |     P=0.343N     P=0.500      P=0.500      P=0.500N    |P=0.518      P=0.500N     P=0.643N     P=0.643N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   42/50 (84%)  45/50 (90%)  47/50 (94%) |4/50 (8%)    37/50 (74%)  39/50 (78%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     6/46.85      42/48.01     45/48.50     47/48.74    |4/45.93      37/47.09     39/45.22     49/50.00     | 
|POLY-3 PERCENT (g) |     12.8%        87.5%        92.8%        96.4%       |8.7%         78.6%        86.2%        98.0%        | 
|TERMINAL (d)       |     5/39 (13%)   30/33 (91%)  34/36 (94%)  27/27 (100%)|2/38 (5%)    26/32 (81%)  27/30 (90%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     710          405          534          387         |681          23           251          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    41/50 (82%)  49/50 (98%)  50/50 (100%)|0/50 (0%)    31/50 (62%)  38/50 (76%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     3/46.78      41/48.96     49/49.96     50/50.00    |0/45.55      31/44.06     38/43.14     50/50.00     | 
|POLY-3 PERCENT (g) |     6.4%         83.7%        98.1%        100.0%      |0.0%         70.4%        88.1%        100.0%       | 
|TERMINAL (d)       |     3/39 (8%)    29/33 (88%)  36/36 (100%) 27/27 (100%)|0/38 (0%)    23/32 (72%)  28/30 (93%)  32/32 (100%) | 
|FIRST INCIDENCE    |     729 (T)      405          422          387         |---          522          416          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  36/50 (72%)  45/50 (90%)  49/50 (98%) |0/50 (0%)    34/50 (68%)  35/50 (70%)  45/50 (90%)  | 
|POLY-3 RATE (b)    |     10/47.09     36/47.41     45/48.78     49/49.42    |0/45.55      34/44.18     35/42.55     45/48.32     | 
|POLY-3 PERCENT (g) |     21.2%        75.9%        92.3%        99.2%       |0.0%         77.0%        82.3%        93.1%        | 
|TERMINAL (d)       |     8/39 (21%)   26/33 (79%)  33/36 (92%)  27/27 (100%)|0/38 (0%)    25/32 (78%)  25/30 (83%)  29/32 (91%)  | 
|FIRST INCIDENCE    |     667          530          534          387         |---          522          534          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole, Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    15/50 (30%)  37/50 (74%)  46/50 (92%) |0/50 (0%)    12/50 (24%)  34/50 (68%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     0/46.78      15/44.85     37/48.30     46/49.67    |0/45.55      12/41.52     34/45.57     48/49.98     | 
|POLY-3 PERCENT (g) |     0.0%         33.4%        76.6%        92.6%       |0.0%         28.9%        74.6%        96.0%        | 
|TERMINAL (d)       |     0/39 (0%)    13/33 (39%)  30/36 (83%)  25/27 (93%) |0/38 (0%)    12/32 (38%)  24/30 (80%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     ---          530          422          387         |---          731 (T)      270          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   9/50 (18%)   12/50 (24%) |0/50 (0%)    1/50 (2%)    4/50 (8%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     1/46.78      6/45.61      9/47.57      12/42.68    |0/45.55      1/41.52      4/40.15      8/44.03      | 
|POLY-3 PERCENT (g) |     2.1%         13.2%        18.9%        28.1%       |0.0%         2.4%         10.0%        18.2%        | 
|TERMINAL (d)       |     1/39 (3%)    2/33 (6%)    2/36 (6%)    5/27 (19%)  |0/38 (0%)    1/32 (3%)    2/30 (7%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      534          534          494         |---          731 (T)      705          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.047 *    P=0.011 *    P<0.001 **  |P<0.001 **   P=0.466      P=0.043 *    P=0.004 **   | 
|POLY 3             |     P<0.001 **   P=0.052      P=0.009 **   P<0.001 **  |P<0.001 **   P=0.482      P=0.046 *    P=0.003 **   | 
|POLY 1.5           |     P<0.001 **   P=0.054      P=0.008 **   P<0.001 **  |P<0.001 **   P=0.487      P=0.051      P=0.003 **   | 
|POLY 6             |     P<0.001 **   P=0.050      P=0.009 **   P<0.001 **  |P<0.001 **   P=0.475      P=0.042 *    P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.003 **   P=0.083      P=0.011 *    P=0.002 **  |P<0.001 **   P=0.466      P=0.044 *    P=0.004 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.056      P=0.008 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.059      P=0.003 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Perivascular                                                                                                               | 
|     Infiltration Cellular                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      0/45.85      0/40.35     |2/45.55      2/41.52      3/40.55      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         4.8%         7.4%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |2/38 (5%)    2/32 (6%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      731 (T)      577          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.243N     P=0.632      P=0.407      P=0.277N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.209N     P=0.660      P=0.447      P=0.248N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.670      P=0.466      P=0.241N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.219N     P=0.648      P=0.434      P=0.255N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.207N     P=0.632      P=0.472      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.199N     P=0.691N     P=0.500      P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node                                                                                                                       | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)    |3/3 (100%)   1/1 (100%)   0/5 (0%)     0/1 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.67       0/0.00       0/0.52      |3/3.00       1/1.00       0/4.89       0/0.71       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |100.0%       100.0%       0.0%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |3/3 (100%)   1/1 (100%)   0/3 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.063N     (e)          P=0.068N     P=1.000N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001N**   (e)          P<0.001N**   P=1.000N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P<0.001N**   (e)          P<0.001N**   P<0.001N**   | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001N**   (e)          P<0.001N**   P=1.000N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.063N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.016N*    (e)          P=0.018N*    P=0.250N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/40 (18%)   7/38 (18%)   12/36 (33%)  13/40 (33%) |3/39 (8%)    13/40 (33%)  14/45 (31%)  20/41 (49%)  | 
|POLY-3 RATE (b)    |     7/38.85      7/34.54      12/34.77     13/35.33    |3/36.66      13/36.01     14/37.77     20/39.30     | 
|POLY-3 PERCENT (g) |     18.0%        20.3%        34.5%        36.8%       |8.2%         36.1%        37.1%        50.9%        | 
|TERMINAL (d)       |     6/33 (18%)   2/23 (9%)    8/27 (30%)   4/21 (19%)  |3/31 (10%)   9/25 (36%)   9/28 (32%)   9/25 (36%)   | 
|FIRST INCIDENCE    |     667          530          617          494         |731 (T)      522          577          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.421      P=0.083      P=0.024 *   |P<0.001 **   P=0.002 **   P=0.002 **   P<0.001 **   | 
|POLY 3             |     P=0.026 *    P=0.521      P=0.087      P=0.057     |P<0.001 **   P=0.003 **   P=0.002 **   P<0.001 **   | 
|POLY 1.5           |     P=0.033 *    P=0.541      P=0.089      P=0.071     |P<0.001 **   P=0.004 **   P=0.003 **   P<0.001 **   | 
|POLY 6             |     P=0.019 *    P=0.499      P=0.085      P=0.044 *   |P<0.001 **   P=0.003 **   P=0.002 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.078      P=0.567N     P=0.099      P=0.167     |P<0.001 **   P=0.006 **   P=0.003 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.047 *    P=0.574      P=0.092      P=0.098     |P<0.001 **   P=0.006 **   P=0.007 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/34 (3%)    0/43 (0%)    1/27 (4%)    1/35 (3%)   |0/41 (0%)    2/40 (5%)    1/40 (3%)    3/46 (7%)    | 
|POLY-3 RATE (b)    |     1/31.74      0/38.91      1/24.86      1/28.33     |0/38.25      2/33.97      1/31.83      3/40.06      | 
|POLY-3 PERCENT (g) |     3.2%         0.0%         4.0%         3.5%        |0.0%         5.9%         3.1%         7.5%         | 
|TERMINAL (d)       |     1/27 (4%)    0/30 (0%)    0/18 (0%)    1/18 (6%)   |0/32 (0%)    2/26 (8%)    1/24 (4%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          639          729 (T)     |---          731 (T)      731 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.440      P=0.479N     P=0.716      P=0.669     |P=0.106      P=0.193      P=0.443      P=0.111      | 
|POLY 3             |     P=0.475      P=0.459N     P=0.705      P=0.735     |P=0.115      P=0.211      P=0.464      P=0.126      | 
|POLY 1.5           |     P=0.493      P=0.457N     P=0.707      P=0.749     |P=0.122      P=0.216      P=0.474      P=0.132      | 
|POLY 6             |     P=0.450      P=0.461N     P=0.703      P=0.715     |P=0.107      P=0.203      P=0.454      P=0.120      | 
|LOGISTIC REGRESSION|     P=0.509      (e)          P=0.724      P=0.669     |P=0.116      P=0.193      P=0.443      P=0.121      | 
|COCH-ARM / FISHERS |     P=0.518      P=0.442N     P=0.693      P=0.746N    |P=0.131      P=0.241      P=0.494      P=0.143      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/38 (5%)    3/36 (8%)    4/43 (9%)    6/37 (16%)  |6/43 (14%)   4/37 (11%)   5/42 (12%)   6/42 (14%)   | 
|POLY-3 RATE (b)    |     2/36.05      3/32.08      4/40.87      6/30.64     |6/41.29      4/33.07      5/35.75      6/38.04      | 
|POLY-3 PERCENT (g) |     5.6%         9.4%         9.8%         19.6%       |14.5%        12.1%        14.0%        15.8%        | 
|TERMINAL (d)       |     1/30 (3%)    2/26 (8%)    1/33 (3%)    2/20 (10%)  |4/35 (11%)   4/25 (16%)   3/28 (11%)   2/27 (7%)    | 
|FIRST INCIDENCE    |     667          639          639          535         |662          731 (T)      577          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.442      P=0.344      P=0.058     |P=0.387      P=0.571N     P=0.607      P=0.499      | 
|POLY 3             |     P=0.053      P=0.447      P=0.396      P=0.083     |P=0.465      P=0.514N     P=0.601N     P=0.563      | 
|POLY 1.5           |     P=0.062      P=0.457      P=0.396      P=0.097     |P=0.475      P=0.493N     P=0.577N     P=0.577      | 
|POLY 6             |     P=0.045 *    P=0.436      P=0.396      P=0.067     |P=0.454      P=0.543N     P=0.616N     P=0.545      | 
|LOGISTIC REGRESSION|     P=0.085      P=0.483      P=0.392      P=0.135     |P=0.478      P=0.517N     P=0.548N     P=0.616      | 
|COCH-ARM / FISHERS |     P=0.075      P=0.474      P=0.399      P=0.122     |P=0.500      P=0.469N     P=0.517N     P=0.605      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    1/47 (2%)    2/48 (4%)    0/44 (0%)   |0/46 (0%)    0/47 (0%)    0/48 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.55      1/42.75      2/44.46      0/36.08     |0/41.55      0/41.52      0/39.58      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/33 (0%)    1/35 (3%)    0/26 (0%)   |0/34 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          639          639          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.641      P=0.486      P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.603      P=0.496      P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.635      P=0.499      P=0.244      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.562      P=0.493      P=0.239      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.576N     P=0.572      P=0.263      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.629N     P=0.505      P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/46 (7%)    7/47 (15%)   2/48 (4%)    2/44 (5%)   |2/46 (4%)    1/47 (2%)    1/48 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.55      7/42.54      2/44.13      2/36.08     |2/41.55      1/41.86      1/39.58      1/43.48      | 
|POLY-3 PERCENT (g) |     6.9%         16.5%        4.5%         5.5%        |4.8%         2.4%         2.5%         2.3%         | 
|TERMINAL (d)       |     3/37 (8%)    5/33 (15%)   2/35 (6%)    2/26 (8%)   |2/34 (6%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      714          729 (T)      729 (T)     |731 (T)      635          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341N     P=0.120      P=0.526N     P=0.659N    |P=0.431N     P=0.530N     P=0.544N     P=0.521N     | 
|POLY 3             |     P=0.273N     P=0.147      P=0.494N     P=0.585N    |P=0.395N     P=0.497N     P=0.517N     P=0.484N     | 
|POLY 1.5           |     P=0.249N     P=0.154      P=0.489N     P=0.559N    |P=0.390N     P=0.490N     P=0.504N     P=0.475N     | 
|POLY 6             |     P=0.304N     P=0.139      P=0.501N     P=0.616N    |P=0.400N     P=0.506N     P=0.527N     P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.342N     P=0.130      P=0.526N     P=0.659N    |P=0.396N     P=0.492N     P=0.544N     P=0.521N     | 
|COCH-ARM / FISHERS |     P=0.215N     P=0.167      P=0.480N     P=0.521N    |P=0.383N     P=0.492N     P=0.484N     P=0.468N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |3/50 (6%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/0.00       0/0.00       0/0.00       0/1.00      |3/45.55      0/41.52      4/40.77      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.6%         0.0%         9.8%         0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)    |3/38 (8%)    0/32 (0%)    3/30 (10%)   0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          416          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.240N     P=0.153N     P=0.386      P=0.153N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.194N     P=0.136N     P=0.440      P=0.127N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.189N     P=0.131N     P=0.462      P=0.122N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.143N     P=0.422      P=0.133N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.200N     (e)          P=0.482      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.199N     P=0.121N     P=0.500      P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/9 (33%)    0/7 (0%)     3/8 (38%)    0/1 (0%)    |1/14 (7%)    1/9 (11%)    1/5 (20%)    0/4 (0%)     | 
|POLY-3 RATE (b)    |     3/9.00       0/6.23       3/7.59       0/1.00      |1/13.59      1/8.68       1/4.51       0/3.11       | 
|POLY-3 PERCENT (g) |     33.3%        0.0%         39.6%        0.0%        |7.4%         11.5%        22.2%        0.0%         | 
|TERMINAL (d)       |     3/9 (33%)    0/5 (0%)     3/6 (50%)    0/1 (0%)    |1/12 (8%)    1/7 (14%)    0/3 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |731 (T)      731 (T)      662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.670      P=0.227N     P=0.459      P=0.669N    |P=0.687      P=0.640      P=0.599      P=1.000N     | 
|POLY 3             |     P=0.604N     P=0.167N     P=0.593      P=0.663N    |P=0.622      P=0.658      P=0.499      P=0.769N     | 
|POLY 1.5           |     P=0.599N     P=0.154N     P=0.607      P=0.663N    |P=0.651N     P=0.659      P=0.506      P=0.759N     | 
|POLY 6             |     P=0.614N     P=0.188N     P=0.570      P=0.663N    |P=0.556      P=0.657      P=0.490      P=0.783N     | 
|LOGISTIC REGRESSION|     P=0.670      (e)          P=0.459      (e)         |P=0.631N     P=0.640      P=0.635      (e)          | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.150N     P=0.627      P=0.700N    |P=0.631N     P=0.640      P=0.468      P=0.778N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/9 (56%)    3/7 (43%)    4/8 (50%)    1/1 (100%)  |11/14 (79%)  9/9 (100%)   5/5 (100%)   3/4 (75%)    | 
|POLY-3 RATE (b)    |     5/9.00       3/6.23       4/7.59       1/1.00      |11/13.68     9/9.00       5/5.00       3/3.43       | 
|POLY-3 PERCENT (g) |     55.6%        48.2%        52.7%        100.0%      |80.4%        100.0%       100.0%       87.6%        | 
|TERMINAL (d)       |     5/9 (56%)    3/5 (60%)    4/6 (67%)    1/1 (100%)  |10/12 (83%)  7/7 (100%)   3/3 (100%)   0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |709          660          584          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.341      P=0.651      P=0.541      P=0.581     |P=0.145      P=0.218      P=0.299      P=0.267      | 
|POLY 3             |     P=0.482      P=0.589N     P=0.641N     P=0.579     |P=0.337      P=0.217      P=0.371      P=0.678      | 
|POLY 1.5           |     P=0.494      P=0.548N     P=0.619N     P=0.579     |P=0.447      P=0.206      P=0.357      P=0.728      | 
|POLY 6             |     P=0.460      P=0.648N     P=0.676N     P=0.579     |P=0.231      P=0.240      P=0.396      P=0.614      | 
|LOGISTIC REGRESSION|     P=0.341      P=0.651      P=0.541      P=0.581     |P=0.188      P=0.173      P=0.235      P=0.342      | 
|COCH-ARM / FISHERS |     P=0.506      P=0.500N     P=0.601N     P=0.600     |P=0.601      P=0.206      P=0.376      P=0.673N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  11/50 (22%)  32/50 (64%)  23/50 (46%) |19/50 (38%)  14/50 (28%)  32/50 (64%)  30/50 (60%)  | 
|POLY-3 RATE (b)    |     16/47.91     11/46.00     32/47.92     23/42.47    |19/48.01     14/42.69     32/45.50     30/45.44     | 
|POLY-3 PERCENT (g) |     33.4%        23.9%        66.8%        54.2%       |39.6%        32.8%        70.3%        66.0%        | 
|TERMINAL (d)       |     12/39 (31%)  7/33 (21%)   26/36 (72%)  16/27 (59%) |13/38 (34%)  11/32 (34%)  20/30 (67%)  24/32 (75%)  | 
|FIRST INCIDENCE    |     499          514          422          546         |181          522          251          478          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.325N     P<0.001 **   P=0.007 **  |P<0.001 **   P=0.388N     P=0.002 **   P=0.006 **   | 
|POLY 3             |     P<0.001 **   P=0.215N     P<0.001 **   P=0.034 *   |P<0.001 **   P=0.326N     P=0.002 **   P=0.007 **   | 
|POLY 1.5           |     P=0.003 **   P=0.202N     P<0.001 **   P=0.056     |P<0.001 **   P=0.288N     P=0.003 **   P=0.012 *    | 
|POLY 6             |     P<0.001 **   P=0.235N     P<0.001 **   P=0.018 *   |P<0.001 **   P=0.375N     P<0.001 **   P=0.004 **   | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.154N     P<0.001 **   P=0.036 *   |P=0.002 **   P=0.223N     P=0.008 **   P=0.021 *    | 
|COCH-ARM / FISHERS |     P=0.014 *    P=0.184N     P<0.001 **   P=0.109     |P=0.002 **   P=0.198N     P=0.008 **   P=0.022 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.75      1/46.66      0/40.35     |0/45.55      0/41.52      2/41.53      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.1%         0.0%        |0.0%         0.0%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          514          422          ---         |---          ---          251          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.603N     P=0.500      P=0.500      (e)         |P=0.602      (e)          P=0.232      (e)          | 
|POLY 3             |     P=0.632N     P=0.491      P=0.499      (e)         |P=0.588      (e)          P=0.217      (e)          | 
|POLY 1.5           |     P=0.617N     P=0.495      P=0.500      (e)         |P=0.599      (e)          P=0.225      (e)          | 
|POLY 6             |     P=0.650N     P=0.487      P=0.498      (e)         |P=0.576      (e)          P=0.211      (e)          | 
|LOGISTIC REGRESSION|     P=0.257N     P=0.715      (e)          (e)         |P=0.494      (e)          P=0.226      (e)          | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Lateral Wall                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      2/45.85      1/40.35     |0/45.55      0/41.52      1/40.45      2/43.59      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         2.5%        |0.0%         0.0%         2.5%         4.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    2/36 (6%)    1/27 (4%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          584          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.177      (e)          P=0.221      P=0.427     |P=0.066      (e)          P=0.468      P=0.213      | 
|POLY 3             |     P=0.196      (e)          P=0.233      P=0.471     |P=0.069      (e)          P=0.476      P=0.227      | 
|POLY 1.5           |     P=0.216      (e)          P=0.235      P=0.483     |P=0.071      (e)          P=0.485      P=0.234      | 
|POLY 6             |     P=0.172      (e)          P=0.230      P=0.455     |P=0.066      (e)          P=0.470      P=0.221      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.221      P=0.427     |P=0.070      (e)          P=0.519      P=0.223      | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.070      (e)          P=0.500      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Lateral Wall                                                                                                               | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.78      1/44.75      1/45.99      1/40.48     |1/45.55      1/42.15      4/42.44      1/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         2.5%        |2.2%         2.4%         9.4%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          514          695          695         |731 (T)      522          251          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.321      P=0.500      P=0.495      P=0.421     |P=0.507      P=0.739      P=0.152      P=0.723      | 
|POLY 3             |     P=0.331      P=0.491      P=0.497      P=0.471     |P=0.510      P=0.743      P=0.158      P=0.750      | 
|POLY 1.5           |     P=0.353      P=0.495      P=0.498      P=0.483     |P=0.526      P=0.748      P=0.167      P=0.757      | 
|POLY 6             |     P=0.304      P=0.487      P=0.495      P=0.456     |P=0.493      P=0.737      P=0.151      P=0.743      | 
|LOGISTIC REGRESSION|     P=0.489      P=0.715      P=0.505      P=0.490     |P=0.466      P=0.750N     P=0.215      P=0.723      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.526      P=0.753N     P=0.181      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   7/50 (14%)   9/50 (18%)   12/50 (24%) |2/50 (4%)    8/50 (16%)   5/50 (10%)   14/50 (28%)  | 
|POLY-3 RATE (b)    |     6/46.90      7/45.07      9/47.77      12/43.03    |2/46.48      8/41.88      5/39.96      14/45.73     | 
|POLY-3 PERCENT (g) |     12.8%        15.5%        18.8%        27.9%       |4.3%         19.1%        12.5%        30.6%        | 
|TERMINAL (d)       |     5/39 (13%)   3/33 (9%)    4/36 (11%)   7/27 (26%)  |0/38 (0%)    5/32 (16%)   5/30 (17%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     698          514          422          387         |505          668          731 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.016 *    P=0.396      P=0.258      P=0.025 *   |P<0.001 **   P=0.031 *    P=0.142      P<0.001 **   | 
|POLY 3             |     P=0.037 *    P=0.469      P=0.301      P=0.062     |P<0.001 **   P=0.030 *    P=0.160      P<0.001 **   | 
|POLY 1.5           |     P=0.044 *    P=0.481      P=0.297      P=0.075     |P<0.001 **   P=0.034 *    P=0.180      P<0.001 **   | 
|POLY 6             |     P=0.029 *    P=0.455      P=0.303      P=0.047 *   |P<0.001 **   P=0.025 *    P=0.144      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.100      P=0.491      P=0.316      P=0.123     |P<0.001 **   P=0.042 *    P=0.198      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.056      P=0.500      P=0.288      P=0.096     |P<0.001 **   P=0.046 *    P=0.218      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    7/50 (14%)   23/50 (46%)  30/50 (60%) |11/50 (22%)  23/50 (46%)  34/50 (68%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     1/46.78      7/44.79      23/47.66     30/45.45    |11/46.79     23/43.40     34/45.52     48/49.05     | 
|POLY-3 PERCENT (g) |     2.1%         15.6%        48.3%        66.0%       |23.5%        53.0%        74.7%        97.9%        | 
|TERMINAL (d)       |     1/39 (3%)    4/33 (12%)   16/36 (44%)  17/27 (63%) |8/38 (21%)   19/32 (59%)  22/30 (73%)  32/32 (100%) | 
|FIRST INCIDENCE    |     729 (T)      558          422          394         |181          564          270          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.026 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.027 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.024 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   22/50 (44%)  38/50 (76%)  41/50 (82%) |35/50 (70%)  39/50 (78%)  46/50 (92%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     8/46.90      22/45.57     38/48.06     41/46.11    |35/47.67     39/44.36     46/47.42     50/50.00     | 
|POLY-3 PERCENT (g) |     17.1%        48.3%        79.1%        88.9%       |73.4%        87.9%        97.0%        100.0%       | 
|TERMINAL (d)       |     7/39 (18%)   15/33 (46%)  28/36 (78%)  25/27 (93%) |27/38 (71%)  29/32 (91%)  29/30 (97%)  32/32 (100%) | 
|FIRST INCIDENCE    |     698          558          534          541         |505          564          270          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.046 *    P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.062      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.093      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.037 *    P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.081      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.247      P=0.005 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    6/50 (12%)   6/50 (12%)   2/50 (4%)   |0/50 (0%)    3/50 (6%)    7/50 (14%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     0/46.78      6/46.24      6/46.70      2/40.48     |0/45.55      3/42.25      7/40.90      8/44.29      | 
|POLY-3 PERCENT (g) |     0.0%         13.0%        12.9%        4.9%        |0.0%         7.1%         17.1%        18.1%        | 
|TERMINAL (d)       |     0/39 (0%)    2/33 (6%)    4/36 (11%)   1/27 (4%)   |0/38 (0%)    1/32 (3%)    5/30 (17%)   5/32 (16%)   | 
|FIRST INCIDENCE    |     ---          514          422          695         |---          522          318          565          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.335      P=0.016 *    P=0.016 *    P=0.161     |P=0.002 **   P=0.105      P=0.005 **   P=0.003 **   | 
|POLY 3             |     P=0.330      P=0.015 *    P=0.015 *    P=0.207     |P=0.002 **   P=0.106      P=0.005 **   P=0.003 **   | 
|POLY 1.5           |     P=0.383      P=0.015 *    P=0.015 *    P=0.219     |P=0.002 **   P=0.109      P=0.006 **   P=0.003 **   | 
|POLY 6             |     P=0.267      P=0.014 *    P=0.015 *    P=0.192     |P=0.002 **   P=0.102      P=0.004 **   P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.534N     P=0.035 *    P=0.020 *    P=0.191     |P=0.003 **   P=0.124      P=0.009 **   P=0.005 **   | 
|COCH-ARM / FISHERS |     P=0.463      P=0.013 *    P=0.013 *    P=0.247     |P=0.003 **   P=0.121      P=0.006 **   P=0.003 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      1/45.85      2/40.35     |0/45.55      0/41.52      1/40.57      7/44.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         5.0%        |0.0%         0.0%         2.5%         15.8%        | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    1/36 (3%)    2/27 (7%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    5/32 (16%)   | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          534          565          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          P=0.484      P=0.162     |P<0.001 **   (e)          P=0.478      P=0.006 **   | 
|POLY 3             |     P=0.057      (e)          P=0.496      P=0.206     |P<0.001 **   (e)          P=0.477      P=0.007 **   | 
|POLY 1.5           |     P=0.062      (e)          P=0.498      P=0.219     |P<0.001 **   (e)          P=0.485      P=0.007 **   | 
|POLY 6             |     P=0.051      (e)          P=0.494      P=0.190     |P<0.001 **   (e)          P=0.471      P=0.006 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.484      P=0.162     |P<0.001 **   (e)          P=0.519      P=0.009 **   | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |P<0.001 **   (e)          P=0.500      P=0.006 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |16/48 (33%)  16/50 (32%)  15/49 (31%)  17/47 (36%)  | 
|POLY-3 RATE (b)    |                                                        |16/44.95     16/42.39     15/41.59     17/43.22     | 
|POLY-3 PERCENT (g) |                                                        |35.6%        37.7%        36.1%        39.3%        | 
|TERMINAL (d)       |                                                        |13/37 (35%)  11/32 (34%)  10/30 (33%)  8/29 (28%)   | 
|FIRST INCIDENCE    |                                                        |505          603          490          550          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.255      P=0.396      P=0.415      P=0.280      | 
|POLY 3             |                                                        |P=0.411      P=0.506      P=0.571      P=0.443      | 
|POLY 1.5           |                                                        |P=0.429      P=0.547      P=0.554N     P=0.467      | 
|POLY 6             |                                                        |P=0.400      P=0.457      P=0.532      P=0.424      | 
|LOGISTIC REGRESSION|                                                        |P=0.389      P=0.527      P=0.564N     P=0.461      | 
|COCH-ARM / FISHERS |                                                        |P=0.411      P=0.530N     P=0.472N     P=0.470      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    5/50 (10%)   2/50 (4%)   |3/50 (6%)    4/50 (8%)    2/49 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/46.90      3/44.10      5/46.46      2/40.35     |3/45.92      4/41.52      2/39.90      4/43.59      | 
|POLY-3 PERCENT (g) |     6.4%         6.8%         10.8%        5.0%        |6.5%         9.6%         5.0%         9.2%         | 
|TERMINAL (d)       |     2/39 (5%)    3/33 (9%)    4/36 (11%)   2/27 (7%)   |2/38 (5%)    4/32 (13%)   2/30 (7%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     698          729 (T)      534          729 (T)     |626          731 (T)      731 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.551      P=0.584      P=0.321      P=0.668N    |P=0.405      P=0.408      P=0.602N     P=0.418      | 
|POLY 3             |     P=0.527N     P=0.634      P=0.351      P=0.568N    |P=0.455      P=0.445      P=0.564N     P=0.472      | 
|POLY 1.5           |     P=0.492N     P=0.645      P=0.354      P=0.540N    |P=0.472      P=0.462      P=0.542N     P=0.489      | 
|POLY 6             |     P=0.560      P=0.619      P=0.346      P=0.604N    |P=0.435      P=0.424      P=0.582N     P=0.452      | 
|LOGISTIC REGRESSION|     P=0.524N     P=0.613      P=0.363      P=0.640N    |P=0.448      P=0.447      P=0.552N     P=0.481      | 
|COCH-ARM / FISHERS |     P=0.442N     P=0.661N     P=0.357      P=0.500N    |P=0.479      P=0.500      P=0.510N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/33 (0%)    0/43 (0%)    0/44 (0%)    0/35 (0%)   |0/42 (0%)    2/41 (5%)    0/43 (0%)    1/39 (3%)    | 
|POLY-3 RATE (b)    |     0/31.22      0/39.13      0/40.52      0/28.58     |0/37.87      2/35.41      0/36.36      1/35.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         5.7%         0.0%         2.8%         | 
|TERMINAL (d)       |     0/26 (0%)    0/31 (0%)    0/34 (0%)    0/20 (0%)   |0/32 (0%)    2/31 (7%)    0/29 (0%)    1/27 (4%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.495      P=0.231      (e)          P=0.466      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.521      P=0.222      (e)          P=0.487      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.527      P=0.222      (e)          P=0.490      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.515      P=0.221      (e)          P=0.484      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.231      (e)          P=0.466      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.523      P=0.241      (e)          P=0.481      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/48 (6%)    3/49 (6%)    0/49 (0%)   |2/49 (4%)    0/50 (0%)    1/50 (2%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     2/46.92      3/42.16      3/44.85      0/39.35     |2/45.54      0/41.52      1/39.96      2/41.06      | 
|POLY-3 PERCENT (g) |     4.3%         7.1%         6.7%         0.0%        |4.4%         0.0%         2.5%         4.9%         | 
|TERMINAL (d)       |     1/39 (3%)    2/32 (6%)    3/35 (9%)    0/26 (0%)   |2/38 (5%)    0/32 (0%)    1/30 (3%)    2/30 (7%)    | 
|FIRST INCIDENCE    |     692          715          729 (T)      ---         |731 (T)      ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265N     P=0.424      P=0.457      P=0.334N    |P=0.398      P=0.277N     P=0.583N     P=0.607      | 
|POLY 3             |     P=0.222N     P=0.451      P=0.479      P=0.278N    |P=0.454      P=0.258N     P=0.545N     P=0.656      | 
|POLY 1.5           |     P=0.198N     P=0.464      P=0.484      P=0.263N    |P=0.458      P=0.252N     P=0.528N     P=0.667      | 
|POLY 6             |     P=0.255N     P=0.436      P=0.472      P=0.300N    |P=0.449      P=0.267N     P=0.559N     P=0.645      | 
|LOGISTIC REGRESSION|     P=0.240N     P=0.439      P=0.473      P=0.279N    |P=0.398      (e)          P=0.583N     P=0.607      | 
|COCH-ARM / FISHERS |     P=0.168N     P=0.480      P=0.490      P=0.253N    |P=0.453      P=0.242N     P=0.492N     P=0.676      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/48 (6%)    0/49 (0%)    1/49 (2%)   |22/49 (45%)  26/50 (52%)  15/50 (30%)  20/47 (43%)  | 
|POLY-3 RATE (b)    |     4/47.53      3/42.27      0/44.85      1/39.35     |22/45.54     26/42.14     15/40.21     20/42.03     | 
|POLY-3 PERCENT (g) |     8.4%         7.1%         0.0%         2.5%        |48.3%        61.7%        37.3%        47.6%        | 
|TERMINAL (d)       |     2/39 (5%)    1/32 (3%)    0/35 (0%)    1/26 (4%)   |22/38 (58%)  23/32 (72%)  12/30 (40%)  13/30 (43%)  | 
|FIRST INCIDENCE    |     499          695          ---          729 (T)     |731 (T)      635          695          611          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123N     P=0.573N     P=0.077N     P=0.297N    |P=0.524N     P=0.053      P=0.350N     P=0.387      | 
|POLY 3             |     P=0.083N     P=0.564N     P=0.068N     P=0.242N    |P=0.311N     P=0.143      P=0.207N     P=0.558N     | 
|POLY 1.5           |     P=0.079N     P=0.547N     P=0.066N     P=0.217N    |P=0.284N     P=0.178      P=0.160N     P=0.526N     | 
|POLY 6             |     P=0.088N     P=0.582N     P=0.071N     P=0.275N    |P=0.326N     P=0.109      P=0.242N     P=0.580N     | 
|LOGISTIC REGRESSION|     P=0.069N     P=0.489N     P=0.052N     P=0.153N    |P=0.408N     P=0.060      P=0.296N     P=0.486      | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.523N     P=0.061N     P=0.187N    |P=0.272N     P=0.307      P=0.093N     P=0.490N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura: Mesothelium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     4/4 (100%)   2/2 (100%)   1/2 (50%)   |0/0 (0%)     1/1 (100%)   0/0 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       4/4.00       2/2.00       1/2.00      |0/0.00       1/1.00       0/0.00       1/1.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       100.0%       50.0%       |0.0%         100.0%       0.0%         100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     2/2 (100%)   1/1 (100%)   0/1 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     ---          639          639          586         |---          718          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.579N     (e)          (e)          P=0.471     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.191N     (e)          (e)          P=1.000     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/49 (31%)  19/50 (38%)  13/50 (26%)  20/49 (41%) |                                                    | 
|POLY-3 RATE (b)    |     15/45.91     19/46.22     13/46.03     20/41.77    |                                                    | 
|POLY-3 PERCENT (g) |     32.7%        41.1%        28.2%        47.9%       |                                                    | 
|TERMINAL (d)       |     14/39 (36%)  11/33 (33%)  11/36 (31%)  12/26 (46%) |                                                    | 
|FIRST INCIDENCE    |     701          514          695          535         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.139      P=0.507N     P=0.017 *   |                                                    | 
|POLY 3             |     P=0.143      P=0.266      P=0.407N     P=0.105     |                                                    | 
|POLY 1.5           |     P=0.177      P=0.273      P=0.399N     P=0.137     |                                                    | 
|POLY 6             |     P=0.111      P=0.262      P=0.419N     P=0.076     |                                                    | 
|LOGISTIC REGRESSION|     P=0.116      P=0.239      P=0.452N     P=0.064     |                                                    | 
|COCH-ARM / FISHERS |     P=0.240      P=0.287      P=0.387N     P=0.200     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    5/50 (10%)   5/50 (10%)   3/49 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     2/45.91      5/44.58      5/46.46      3/39.35     |                                                    | 
|POLY-3 PERCENT (g) |     4.4%         11.2%        10.8%        7.6%        |                                                    | 
|TERMINAL (d)       |     1/39 (3%)    3/33 (9%)    4/36 (11%)   3/26 (12%)  |                                                    | 
|FIRST INCIDENCE    |     701          590          534          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.332      P=0.169      P=0.195      P=0.321     |                                                    | 
|POLY 3             |     P=0.403      P=0.204      P=0.221      P=0.430     |                                                    | 
|POLY 1.5           |     P=0.449      P=0.212      P=0.223      P=0.459     |                                                    | 
|POLY 6             |     P=0.344      P=0.194      P=0.217      P=0.393     |                                                    | 
|LOGISTIC REGRESSION|     P=0.459      P=0.215      P=0.231      P=0.351     |                                                    | 
|COCH-ARM / FISHERS |     P=0.515      P=0.226      P=0.226      P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/49 (4%)    0/49 (0%)    0/49 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     4/46.87      2/43.43      0/44.85      0/39.94     |                                                    | 
|POLY-3 PERCENT (g) |     8.5%         4.6%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/39 (5%)    1/33 (3%)    0/35 (0%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     710          728          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032N*    P=0.410N     P=0.080N     P=0.126N    |                                                    | 
|POLY 3             |     P=0.019N*    P=0.373N     P=0.066N     P=0.083N    |                                                    | 
|POLY 1.5           |     P=0.018N*    P=0.363N     P=0.065N     P=0.074N    |                                                    | 
|POLY 6             |     P=0.020N*    P=0.386N     P=0.068N     P=0.097N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.028N*    P=0.391N     P=0.071N     P=0.105N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.349N     P=0.061N     P=0.061N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.78      4/44.87      2/45.85      0/40.35     |0/45.55      0/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         8.9%         4.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    2/33 (6%)    2/36 (6%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          614          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.429N     P=0.053      P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.413N     P=0.055      P=0.233      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.381N     P=0.057      P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.456N     P=0.053      P=0.230      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.332N     P=0.074      P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.337N     P=0.059      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.78      2/44.23      0/45.85      0/40.35     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    1/33 (3%)    0/36 (0%)    0/27 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          695          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.471N     P=0.208      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.434N     P=0.225      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.423N     P=0.230      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.448N     P=0.219      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.434N     P=0.225      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.78      0/44.10      1/45.85      1/40.93     |1/45.55      2/43.01      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.2%         2.4%        |2.2%         4.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/33 (0%)    1/36 (3%)    0/27 (0%)   |1/38 (3%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      545         |731 (T)      23           ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480      P=0.533N     P=0.744      P=0.712     |P=0.205N     P=0.472      P=0.547N     P=0.534N     | 
|POLY 3             |     P=0.506      P=0.512N     P=0.756      P=0.730     |P=0.202N     P=0.480      P=0.526N     P=0.509N     | 
|POLY 1.5           |     P=0.520      P=0.507N     P=0.758      P=0.743     |P=0.195N     P=0.487      P=0.517N     P=0.503N     | 
|POLY 6             |     P=0.487      P=0.517N     P=0.754      P=0.713     |P=0.209N     P=0.471      P=0.534N     P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.588      (e)          P=0.744      P=0.693N    |P=0.222N     P=0.604      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.539      P=0.500N     P=0.753N     P=0.753N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.85      0/44.10      0/45.85      0/40.35     |0/45.55      1/42.01      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     710          ---          ---          ---         |---          584          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.143N     P=0.270N     P=0.257N     P=0.329N    |P=0.578N     P=0.482      (e)          (e)          | 
|POLY 3             |     P=0.104N     P=0.251N     P=0.242N     P=0.272N    |P=0.586N     P=0.484      (e)          (e)          | 
|POLY 1.5           |     P=0.108N     P=0.245N     P=0.240N     P=0.257N    |P=0.579N     P=0.488      (e)          (e)          | 
|POLY 6             |     P=0.099N     P=0.258N     P=0.245N     P=0.292N    |P=0.594N     P=0.478      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.130N     P=0.256N     P=0.243N     P=0.295N    |P=0.584N     P=0.524      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Prepuce                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/46.92      1/44.11      1/46.66      2/40.93     |0/45.55      0/41.52      0/39.96      0/43.48      | 
|POLY-3 PERCENT (g) |     14.9%        2.3%         2.1%         4.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/39 (13%)   0/33 (0%)    0/36 (0%)    1/27 (4%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     698          728          422          545         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.116N     P=0.058N     P=0.045N*    P=0.195N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.063N     P=0.037N*    P=0.031N*    P=0.116N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.062N     P=0.034N*    P=0.030N*    P=0.100N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.063N     P=0.041N*    P=0.031N*    P=0.141N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.048N*    P=0.045N*    P=0.027N*    P=0.107N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.064N     P=0.030N*    P=0.030N*    P=0.080N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  13/50 (26%)  18/50 (36%)  10/50 (20%) |21/50 (42%)  12/48 (25%)  18/49 (37%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     15/47.12     13/46.33     18/47.24     10/41.60    |21/47.23     12/43.03     18/41.92     11/45.24     | 
|POLY-3 PERCENT (g) |     31.8%        28.1%        38.1%        24.0%       |44.5%        27.9%        42.9%        24.3%        | 
|TERMINAL (d)       |     12/39 (31%)  9/33 (27%)   11/36 (31%)  6/27 (22%)  |14/38 (37%)  9/32 (28%)   12/30 (40%)  5/32 (16%)   | 
|FIRST INCIDENCE    |     692          405          606          541         |505          522          416          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534N     P=0.582      P=0.271      P=0.533N    |P=0.139N     P=0.146N     P=0.485      P=0.092N     | 
|POLY 3             |     P=0.330N     P=0.432N     P=0.336      P=0.281N    |P=0.056N     P=0.076N     P=0.527N     P=0.032N*    | 
|POLY 1.5           |     P=0.272N     P=0.422N     P=0.335      P=0.235N    |P=0.049N*    P=0.064N     P=0.463N     P=0.026N*    | 
|POLY 6             |     P=0.404N     P=0.447N     P=0.340      P=0.347N    |P=0.065N     P=0.097N     P=0.584N     P=0.041N*    | 
|LOGISTIC REGRESSION|     P=0.247N     P=0.401N     P=0.314      P=0.333N    |P=0.054N     P=0.063N     P=0.460N     P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.197N     P=0.412N     P=0.335      P=0.178N    |P=0.051N     P=0.058N     P=0.371N     P=0.026N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   12/50 (24%)  15/50 (30%)  10/50 (20%) |17/50 (34%)  18/48 (38%)  15/49 (31%)  15/50 (30%)  | 
|POLY-3 RATE (b)    |     9/46.78      12/44.16     15/45.85     10/40.35    |17/45.64     18/42.20     15/41.35     15/44.25     | 
|POLY-3 PERCENT (g) |     19.2%        27.2%        32.7%        24.8%       |37.3%        42.7%        36.3%        33.9%        | 
|TERMINAL (d)       |     9/39 (23%)   11/33 (33%)  15/36 (42%)  10/27 (37%) |16/38 (42%)  15/32 (47%)  12/30 (40%)  11/32 (34%)  | 
|FIRST INCIDENCE    |     729 (T)      715          729 (T)      729 (T)     |709          635          416          565          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.144      P=0.173      P=0.071      P=0.172     |P=0.506N     P=0.263      P=0.449      P=0.541      | 
|POLY 3             |     P=0.300      P=0.258      P=0.105      P=0.358     |P=0.333N     P=0.382      P=0.551N     P=0.455N     | 
|POLY 1.5           |     P=0.371      P=0.280      P=0.111      P=0.417     |P=0.307N     P=0.413      P=0.507N     P=0.426N     | 
|POLY 6             |     P=0.217      P=0.234      P=0.097      P=0.286     |P=0.359N     P=0.347      P=0.584N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.124      P=0.196      P=0.071      P=0.172     |P=0.374N     P=0.283      P=0.580      P=0.536N     | 
|COCH-ARM / FISHERS |     P=0.477      P=0.312      P=0.121      P=0.500     |P=0.300N     P=0.440      P=0.442N     P=0.415N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.78      0/44.10      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.96      2/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.209      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.227      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.233      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.220      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.214      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.78      2/44.63      1/45.85      0/40.35     |0/45.55      0/41.52      1/39.96      1/43.48      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.2%         0.0%        |0.0%         0.0%         2.5%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    1/36 (3%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    1/30 (3%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          590          729 (T)      ---         |---          ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534N     P=0.221      P=0.484      (e)         |P=0.215      (e)          P=0.453      P=0.466      | 
|POLY 3             |     P=0.512N     P=0.227      P=0.496      (e)         |P=0.234      (e)          P=0.474      P=0.491      | 
|POLY 1.5           |     P=0.491N     P=0.231      P=0.498      (e)         |P=0.239      (e)          P=0.483      P=0.497      | 
|POLY 6             |     P=0.538N     P=0.222      P=0.494      (e)         |P=0.227      (e)          P=0.466      P=0.484      | 
|LOGISTIC REGRESSION|     P=0.431N     P=0.281      P=0.484      (e)         |(e)          (e)          P=0.453      P=0.466      | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.92      2/44.71      2/46.70      1/40.86     |1/45.74      1/42.29      2/40.84      1/43.77      | 
|POLY-3 PERCENT (g) |     2.1%         4.5%         4.3%         2.5%        |2.2%         2.4%         4.9%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     692          626          422          573         |681          446          353          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.594      P=0.464      P=0.489      P=0.699     |P=0.570      P=0.733      P=0.442      P=0.734      | 
|POLY 3             |     P=0.598      P=0.483      P=0.498      P=0.729     |P=0.579      P=0.743      P=0.461      P=0.751      | 
|POLY 1.5           |     P=0.585N     P=0.490      P=0.500      P=0.742     |P=0.590      P=0.748      P=0.476      P=0.757      | 
|POLY 6             |     P=0.562      P=0.476      P=0.495      P=0.711     |P=0.568      P=0.736      P=0.448      P=0.744      | 
|LOGISTIC REGRESSION|     P=0.359N     P=0.564      P=0.577      P=0.686N    |P=0.560      P=0.734N     P=0.535      P=0.762      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.500      P=0.753N    |P=0.591      P=0.753N     P=0.500      P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    10/50 (20%)  6/50 (12%)   4/50 (8%)   |3/50 (6%)    1/50 (2%)    7/50 (14%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/47.03      10/47.37     6/47.13      4/41.19     |3/45.74      1/42.29      7/42.97      1/43.77      | 
|POLY-3 PERCENT (g) |     6.4%         21.1%        12.7%        9.7%        |6.6%         2.4%         16.3%        2.3%         | 
|TERMINAL (d)       |     1/39 (3%)    2/33 (6%)    3/36 (8%)    1/27 (4%)   |2/38 (5%)    0/32 (0%)    2/30 (7%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     692          514          422          590         |681          446          318          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.517      P=0.033 *    P=0.226      P=0.323     |P=0.460N     P=0.361N     P=0.109      P=0.361N     | 
|POLY 3             |     P=0.540N     P=0.036 *    P=0.243      P=0.428     |P=0.429N     P=0.334N     P=0.132      P=0.321N     | 
|POLY 1.5           |     P=0.494N     P=0.035 *    P=0.244      P=0.457     |P=0.415N     P=0.326N     P=0.142      P=0.311N     | 
|POLY 6             |     P=0.508      P=0.036 *    P=0.240      P=0.392     |P=0.445N     P=0.346N     P=0.125      P=0.333N     | 
|LOGISTIC REGRESSION|     P=0.228N     P=0.074      P=0.271      P=0.511     |P=0.450N     P=0.290N     P=0.195      P=0.307N     | 
|COCH-ARM / FISHERS |     P=0.426N     P=0.036 *    P=0.243      P=0.500     |P=0.420N     P=0.309N     P=0.159      P=0.309N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   1/50 (2%)    5/50 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     4/47.52      7/44.16      1/45.93      5/40.76     |                                                    | 
|POLY-3 PERCENT (g) |     8.4%         15.9%        2.2%         12.3%       |                                                    | 
|TERMINAL (d)       |     1/39 (3%)    6/33 (18%)   0/36 (0%)    3/27 (11%)  |                                                    | 
|FIRST INCIDENCE    |     620          715          709          654         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.426      P=0.190      P=0.206N     P=0.307     |                                                    | 
|POLY 3             |     P=0.542      P=0.220      P=0.189N     P=0.405     |                                                    | 
|POLY 1.5           |     P=0.557N     P=0.237      P=0.185N     P=0.444     |                                                    | 
|POLY 6             |     P=0.502      P=0.200      P=0.196N     P=0.356     |                                                    | 
|LOGISTIC REGRESSION|     P=0.544      P=0.238      P=0.164N     P=0.472     |                                                    | 
|COCH-ARM / FISHERS |     P=0.517N     P=0.262      P=0.181N     P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/48 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.78      0/44.10      0/45.85      0/40.35     |0/45.55      0/41.52      0/39.85      2/43.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/37 (0%)    0/33 (0%)    0/36 (0%)    0/27 (0%)   |0/38 (0%)    0/32 (0%)    0/30 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.216      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.228      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.234      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.221      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.231      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.047 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   1/1 (100%)   2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     1/1 (100%)   | 
|POLY-3 RATE (b)    |     2/2.00       1/1.00       2/2.00       0/0.00      |0/0.00       0/0.00       0/0.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       0.0%        |0.0%         0.0%         0.0%         100.0%       | 
|TERMINAL (d)       |     2/2 (100%)   1/1 (100%)   2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   4/49 (8%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |5/45.55      4/41.52      1/39.90      0/43.48      | 
|POLY-3 PERCENT (g) |                                                        |11.0%        9.6%         2.5%         0.0%         | 
|TERMINAL (d)       |                                                        |5/38 (13%)   4/32 (13%)   1/30 (3%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.017N*    P=0.608N     P=0.163N     P=0.049N*    | 
|POLY 3             |                                                        |P=0.011N*    P=0.558N     P=0.135N     P=0.034N*    | 
|POLY 1.5           |                                                        |P=0.010N*    P=0.541N     P=0.123N     P=0.032N*    | 
|POLY 6             |                                                        |P=0.012N*    P=0.579N     P=0.145N     P=0.037N*    | 
|LOGISTIC REGRESSION|                                                        |P=0.017N*    P=0.608N     P=0.163N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.011N*    P=0.513N     P=0.107N     P=0.028N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/19/01                           EXPERIMENT: 61427 TEST: 08                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 VANADIUM PENTOXIDE     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      1.0          2.0          4.0         |CONTROL      1.0          2.0          4.0          | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |46/50 (92%)  43/49 (88%)  42/49 (86%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |                                                        |46/47.95     43/46.05     42/43.60     41/47.06     | 
|POLY-3 PERCENT (g) |                                                        |95.9%        93.4%        96.3%        87.1%        | 
|TERMINAL (d)       |                                                        |37/38 (97%)  31/32 (97%)  30/30 (100%) 30/32 (94%)  | 
|FIRST INCIDENCE    |                                                        |505          446          490          255          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.454      P=0.245      P=0.157      P=0.453      | 
|POLY 3             |                                                        |P=0.050N     P=0.462N     P=0.694      P=0.098N     | 
|POLY 1.5           |                                                        |P=0.028N*    P=0.419N     P=0.491N     P=0.062N     | 
|POLY 6             |                                                        |P=0.120N     P=0.543N     P=0.509      P=0.192N     | 
|LOGISTIC REGRESSION|                                                        |P=0.054N     P=0.489N     P=0.623      P=0.099N     | 
|COCH-ARM / FISHERS |                                                        |P=0.091N     P=0.357N     P=0.251N     P=0.117N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).