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TDMS Study 61427-08 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:35:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#2/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                    VANADIUM PENTOXIDE                                  DATE: 11/19/01       
EXPERIMENT: 61427 TEST: 08                                                                                     TIME: 10:35:44       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-55392                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61427B       
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 1314-62-1       
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      499   523   603   620   620   667   692   698   701   710                 |                                                 
 |      724                                                                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 1.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      405   514   530   534   558   590   614   626   639   639                 |                                                 
 |      666   667   695   714   715   722   728                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 2.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      422   534   606   611   617   639   639   653   695   695                 |                                                 
 |      695   709   718   718                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 4.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      387   394   494   535   541   545   546   562   573   586                 |                                                 
 |      586   590   639   653   654   667   667   667   670   676                 |                                                 
 |      682   695   705                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  94.0  90.0  78.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1.0        |   100.0 100.0 100.0 100.0  98.0  98.0  92.0  88.0  80.0  66.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2.0        |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  96.0  84.0  72.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |4.0        |   100.0 100.0 100.0 100.0  96.0  96.0  88.0  76.0  70.0  54.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      1.0          2.0          4.0      |                                                 
 |                                             MG/M3        MG/M3        MG/M3    |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       78.0%        66.0%        72.0%        54.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.012      P=0.242      P=0.628      P=0.011  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       641.5        620.9        639.4        596.3    |                                                 
 |NATURAL DEATHS (C)      |       (23.0)       (21.7)       (21.9)       (18.5)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       709.8        692.3        703.9        667.9    |                                                 
 |(STANDARD ERROR)        |       ( 7.1)       (10.3)       ( 8.3)       (12.6)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = CONTROL                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      16    181   505   626   642   662   681   683   686   695                 |                                                 
 |      709   715                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 1.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 3    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      446   522   530   564   584   603   610   635   654   660                 |                                                 
 |      660   668   705   718   726                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      23    23    23                                                            |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 2.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 2    TERMINAL 30        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      270   281   353   416   490   501   534   577   584   639                 |                                                 
 |      646   662   666   695   705   709   709   725                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      251   318                                                                 |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 4.0     MG/M3                                  |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      255   478   542   550   550   565   565   611   612   639                 |                                                 
 |      653   687   695   705   705   725   726   728                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                VANADIUM PENTOXIDE                                                                                  
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 731 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |CONTROL    |    98.0  98.0  96.0  96.0  96.0  96.0  94.0  94.0  88.0  76.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1.0        |   100.0 100.0 100.0 100.0 100.0  97.9  93.6  87.2  76.6  68.1      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |2.0        |   100.0 100.0  98.0  93.8  91.7  91.7  85.5  81.3  75.1  62.6      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 |4.0        |   100.0 100.0  98.0  98.0  98.0  96.0  94.0  86.0  78.0  64.0      |                                                 
 |MG/M3      |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                CONTROL      1.0          2.0          4.0      |                                                 
 |                                             MG/M3        MG/M3        MG/M3    |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       76.0%        68.1%        62.6%        64.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.257      P=0.475      P=0.192      P=0.270  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       566.8        619.0        564.6        610.6    |                                                 
 |NATURAL DEATHS (C)      |       (65.9)       (20.4)       (35.3)       (27.6)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       691.6        654.9        653.2        687.7    |                                                 
 |(STANDARD ERROR)        |       (18.3)       (24.7)       (20.0)       (12.8)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                         VANADIUM PENTOXIDE                                                         
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        1.0     MG/M3    = 2                                                        
                                                        2.0     MG/M3    = 3                                                        
                                                        4.0     MG/M3    = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  104 +                                                                                                                             
      |                                                                                                                             
      | 1                                                             4 2  3           1                                            
      |                                                               442  3           1 2 1 3                                      
   96 +                                                                4              4  2 123          1                           
      |                                                                               4     22          131                         
P     |                                                                                      24 2        33                         
E     |                                                                                         2     2   1  3    1                 
R  88 +                                                                                               2  2        1  1              
C     |                                                                                       4  4       2 2 3 3     11             
E     |                                                                                          44        2 2 3      11            
N     |                                                                                           4 4                  11           
T  80 +                                                                                                      2    2     1 1         
      |                                                                                             4 4               3 3 1 1       
S     |                                                                                               4      4    2   2 33          
U     |                                                                                                      4 4      2 2           
R  72 +                                                                                                                 22  3       
V     |                                                                                                        4  4      22         
I     |                                                                                                                             
V     |                                                                                                                   2 2       
A  64 +                                                                                                                             
L     |                                                                                                           44                
      |                                                                                                            44               
      |                                                                                                             4 4             
   56 +                                                                                                               44            
      |                                                                                                                4    4       
      |                                                                                                                             
      |                                                                                                                             
   48 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 10 obs hidden.                                                                                                                
                                                                                                                                   
                                                         VANADIUM PENTOXIDE                                                         
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        CONTROL          = 1                                                        
                                                        1.0     MG/M3    = 2                                                        
                                                        2.0     MG/M3    = 3                                                        
                                                        4.0     MG/M3    = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1  1                                     4 3                          2                                                     
      |                                                                                                                             
      |    1                         1           4 3 3                        2     4      2                                        
      |                              1               3          3                   4   1  22 4                                     
   95 +                                                                                                                             
      |                                                         3         3             1   2 44 2         1                        
      |                                                                                                    1 1                      
      |                                                                   3          3           2  2                               
P  90 +                                                                              3 3       4 4           1   1                  
E     |                                                                                             2   2                           
R     |                                                                                3     3          22       1  1               
C     |                                                                                          4       4                          
E  85 +                                                                                      3     3     2  2                       
N     |                                                                                            33                               
T     |                                                                                                  4  24 2    1 1             
      |                                                                                             3        3 2 2                  
S  80 +                                                                                                      4 4      1 1           
U     |                                                                                                      33                     
R     |                                                                                                       34 3   4  11          
V     |                                                                                                          22  44  1  1       
I  75 +                                                                                                          32    2            
V     |                                                                                                               44            
A     |                                                                                                           3   32 2          
L     |                                                                                                               33            
   70 +                                                                                                                4 22         
      |                                                                                                                33           
      |                                                                                                                   2 2       
      |                                                                                                                             
   65 +                                                                                                                 3 3         
      |                                                                                                                   4 4       
      |                                                                                                                   3 3       
      |                                                                                                                             
   60 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 5 obs hidden.