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TDMS Study 88007-05 Pathology Tables

NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99
Route: DOSED WATER                                                                                                Time: 13:44:04

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7632-00-0

       Lock Date:  03/20/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            6           10           15                                     
    Natural Death                                      6           13            4            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           31           36           33                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)         (50)                                   
      Inflammation                                                               1 (2%)                                             
   Intestine Large, Colon                             (50)         (48)         (50)         (50)                                   
      Parasite Metazoan                                             1 (2%)       1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                             1 (2%)                                
      Parasite Metazoan                                4 (8%)       1 (2%)       2 (4%)       7 (14%)                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       3 (6%)       5 (10%)                               
      Basophilic Focus                                45 (90%)     42 (84%)     48 (96%)     45 (90%)                               
      Clear Cell Focus                                 9 (18%)      6 (12%)      8 (16%)      7 (14%)                               
      Cyst                                                                                    1 (2%)                                
      Eosinophilic Focus                               9 (18%)     10 (20%)      8 (16%)     10 (20%)                               
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       4 (8%)      11 (22%)      7 (14%)      8 (16%)                               
      Inflammation, Chronic Active                    23 (46%)     23 (46%)     28 (56%)     28 (56%)                               
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
      Mixed Cell Focus                                11 (22%)      3 (6%)       7 (14%)      9 (18%)                               
      Necrosis                                         5 (10%)      2 (4%)                    4 (8%)                                
      Pigmentation, Lipofuscin                                                   1 (2%)                                             
      Regeneration                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)       5 (10%)      4 (8%)       4 (8%)                                
      Bile Duct, Hyperplasia                           8 (16%)      4 (8%)       4 (8%)       4 (8%)                                
   Mesentery                                          (7)          (5)          (7)          (4)                                    
      Fat, Inflammation, Chronic Active                6 (86%)      5 (100%)     7 (100%)     4 (100%)                              
      Fat, Necrosis                                    1 (14%)                                                                      
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Acinus, Atrophy                                  6 (12%)      6 (12%)      8 (16%)      8 (16%)                               
      Acinus, Hyperplasia                              1 (2%)                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)       2 (4%)       2 (4%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Ulcer                                            4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Epithelium, Hyperplasia                          8 (16%)      6 (12%)      8 (16%)     40 (80%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                2 (4%)                                                          
   Heart                                              (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       4 (8%)       3 (6%)       3 (6%)                                
      Mineralization                                                2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                     40 (80%)     39 (78%)     45 (90%)     45 (90%)                               
      Degeneration                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                     15 (30%)     11 (22%)     11 (22%)     10 (20%)                               
      Hypertrophy                                      8 (16%)      7 (14%)      7 (14%)      4 (8%)                                
      Necrosis                                         2 (4%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                        4 (8%)       5 (10%)      1 (2%)       3 (6%)                                
   Adrenal Medulla                                    (50)         (50)         (45)         (49)                                   
      Hyperplasia                                      6 (12%)      7 (14%)      4 (9%)       5 (10%)                               
      Bilateral, Hyperplasia                                                     1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Hemorrhage                                       3 (6%)                                                                       
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Pars Distalis, Angiectasis                       2 (4%)                                                                       
      Pars Distalis, Cyst                              4 (8%)      10 (20%)      5 (10%)      9 (18%)                               
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     10 (20%)     19 (38%)     12 (24%)                               
      Pars Intermedia, Cyst                                                                   1 (2%)                                
   Thyroid Gland                                      (50)         (49)         (48)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)       4 (8%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Bilateral, C-Cell, Hyperplasia                                1 (2%)                                                          
      C-Cell, Hyperplasia                             24 (48%)     26 (53%)     34 (71%)     26 (52%)                               
      Follicle, Cyst                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (49)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             9 (20%)      1 (2%)      12 (24%)      3 (6%)                                
      Hyperplasia                                      8 (17%)      4 (8%)       7 (14%)      7 (14%)                               
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Cyst                                             4 (8%)       4 (8%)       3 (6%)       5 (10%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Follicle, Cyst                                   1 (2%)                    2 (4%)       2 (4%)                                
      Periovarian Tissue, Cyst                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)                                                          
      Dysplasia                                                                               1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       2 (4%)       1 (2%)                                
      Hydrometra                                       3 (6%)       4 (8%)       4 (8%)       5 (10%)                               
      Inflammation, Chronic Active                                               1 (2%)                                             
      Thrombosis                                                                 2 (4%)       1 (2%)                                
      Cervix, Hydrometra                                                         1 (2%)                                             
      Cervix, Hyperplasia                                                                     1 (2%)                                
      Cervix, Hypertrophy                              1 (2%)                                                                       
      Cervix, Epithelium, Cyst                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (2)          (1)          (2)          (1)                                    
      Ectasia                                                                                 1 (100%)                              
   Lymph Node, Mandibular                             (49)         (49)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Pigmentation, Lipofuscin                                      1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Lymphoid Follicle, Depletion Cellular                                                   1 (2%)                                
   Thymus                                             (49)         (47)         (49)         (48)                                   
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                     14 (28%)     10 (20%)     12 (24%)     10 (20%)                               
      Hyperplasia                                     10 (20%)      5 (10%)      3 (6%)       9 (18%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                                                                   2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosclerosis                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                                              1 (2%)       1 (2%)                                
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                    16 (32%)     13 (26%)     14 (28%)     17 (34%)                               
      Pigmentation                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                10 (20%)     10 (20%)      8 (16%)      3 (6%)                                
      Bronchiole, Epithelium, Hyperplasia              1 (2%)                    1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            3 (6%)                                
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)          (3)                                    
      Inflammation, Chronic Active                                  1 (100%)                                                        
      Cornea, Inflammation, Chronic Active                                                    1 (33%)                               
      Lens, Mineralization                                                                    1 (33%)                               
      Retina, Degeneration                                                       1 (100%)     3 (100%)                              
   Harderian Gland                                                                           (1)                                    
      Inflammation, Chronic Active                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Casts Protein                                                                           1 (2%)                                
      Cyst                                                                       2 (4%)       4 (8%)                                
      Infarct                                          1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       5 (10%)      4 (8%)       5 (10%)                               
      Mineralization                                   1 (2%)       1 (2%)       2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
      Nephropathy                                     14 (28%)     16 (32%)     20 (40%)     23 (46%)                               
      Pigmentation                                     2 (4%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Regeneration                                    1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)       5 (10%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16            4           12            8                                     
    Natural Death                                      5            8            2            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           37           36           36                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                5 (10%)      4 (8%)       3 (6%)       2 (4%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Congestion                                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)       3 (6%)       1 (2%)                                
      Basophilic Focus                                31 (62%)     34 (68%)     37 (74%)     42 (84%)                               
      Clear Cell Focus                                19 (38%)     25 (50%)     26 (52%)     23 (46%)                               
      Cyst                                                                                    1 (2%)                                
      Degeneration                                     1 (2%)                                                                       
      Degeneration, Cystic                             5 (10%)     15 (30%)     12 (24%)      4 (8%)                                
      Eosinophilic Focus                               4 (8%)      10 (20%)     11 (22%)      6 (12%)                               
      Fibrosis                                         2 (4%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                      11 (22%)      6 (12%)      4 (8%)       8 (16%)                               
      Inflammation, Chronic Active                    13 (26%)     19 (38%)     25 (50%)     24 (48%)                               
      Mixed Cell Focus                                 7 (14%)      7 (14%)      4 (8%)       2 (4%)                                
      Necrosis                                         5 (10%)      2 (4%)       1 (2%)       4 (8%)                                
      Regeneration                                     1 (2%)       1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                        8 (16%)      5 (10%)      4 (8%)       1 (2%)                                
      Bile Duct, Hyperplasia                          41 (82%)     38 (76%)     43 (86%)     38 (76%)                               
   Mesentery                                          (11)         (7)          (5)          (8)                                    
      Fat, Inflammation, Chronic Active                8 (73%)      5 (71%)      5 (100%)     6 (75%)                               
      Fat, Mineralization                              1 (9%)                                                                       
      Fat, Necrosis                                                              1 (20%)                                            
   Oral Mucosa                                        (2)                       (1)                                                 
      Pharyngeal, Cyst                                 1 (50%)                                                                      
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Atrophy                                 16 (32%)     27 (54%)     22 (44%)     28 (57%)                               
      Acinus, Hyperplasia                              4 (8%)       3 (6%)       6 (12%)      8 (16%)                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                                       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)                    1 (2%)       1 (2%)                                
      Erosion                                          2 (4%)                                                                       
      Hyperkeratosis                                                1 (2%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                                             1 (2%)       1 (2%)                                
      Ulcer                                            4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Epithelium, Hyperplasia                         12 (24%)      9 (18%)     10 (20%)     44 (88%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                          1 (2%)                    3 (6%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Ulcer                                            2 (4%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Tongue                                                                       (1)                                                 
      Epithelium, Hyperplasia                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     9 (18%)     15 (30%)     16 (32%)     12 (24%)                               
      Thrombosis                                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Angiectasis                                     16 (32%)     21 (42%)     15 (30%)     22 (44%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                     11 (22%)     15 (30%)     15 (30%)     10 (20%)                               
      Hypertrophy                                      7 (14%)      7 (14%)      2 (4%)       9 (18%)                               
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic                        3 (6%)       3 (6%)       8 (16%)      3 (6%)                                
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 (22%)     18 (36%)     16 (32%)     13 (26%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          2 (4%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Pigmentation, Hemosiderin                                                  1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                                    1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)     18 (36%)     10 (20%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             11 (22%)     17 (34%)     16 (32%)     13 (26%)                               
      Follicle, Cyst                                                3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                     8 (16%)     10 (20%)      6 (12%)      1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                         34 (68%)     34 (68%)     36 (72%)     33 (67%)                               
      Cyst                                                                       1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Degeneration                                     8 (16%)     12 (24%)     11 (22%)     11 (22%)                               
      Mineralization                                   7 (14%)      1 (2%)       2 (4%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                   9 (18%)      6 (12%)      9 (18%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Myelofibrosis                                    1 (2%)                    3 (6%)                                             
   Lymph Node                                         (5)          (4)          (4)          (2)                                    
      Ectasia                                                                    1 (25%)                                            
      Pancreatic, Ectasia                              1 (20%)                                                                      
   Lymph Node, Mandibular                             (48)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                                 1 (2%)                                
      Hyperplasia                                      1 (2%)                    1 (2%)       2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                    1 (2%)       1 (2%)                                             
      Ectasia                                                                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Pigmentation, Lipofuscin                         1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)                    1 (2%)                                             
      Congestion                                       2 (4%)       3 (6%)                                                          
      Fibrosis                                         2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Hematopoietic Cell Proliferation                 5 (10%)                   2 (4%)       1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)       1 (2%)                                
      Capsule, Fibrosis                                             1 (2%)                                                          
      Lymphoid Follicle, Depletion Cellular                         1 (2%)                                                          
   Thymus                                             (50)         (49)         (49)         (48)                                   
      Atrophy                                                       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (47)         (47)         (47)                                   
      Cyst                                                          1 (2%)                                                          
      Galactocele                                                   2 (4%)                    1 (2%)                                
      Hyperplasia                                      4 (9%)       6 (13%)      4 (9%)       3 (6%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Acanthosis                                                                 1 (2%)                                             
      Hyperkeratosis                                                1 (2%)       1 (2%)                                             
      Hyperplasia, Basal Cell                          1 (2%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Epidermis, Cyst                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hydrocephalus                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                 1 (2%)       2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                    18 (36%)      7 (14%)     11 (22%)     11 (22%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Parasite Metazoan                                             1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                11 (22%)     11 (22%)     20 (40%)     14 (28%)                               
      Bronchiole, Epithelium, Hyperplasia                                                     1 (2%)                                
      Bronchus, Inflammation, Suppurative              1 (2%)                                                                       
      Interstitium, Fibrosis                                                     1 (2%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)          (2)                                    
      Hemorrhage                                                                 1 (100%)                                           
      Lens Capsule, Mineralization                                                            1 (50%)                               
      Retina, Degeneration                                                                    2 (100%)                              
      Retrobulbar, Inflammation, Chronic Active                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Crystals                                                                                1 (2%)                                
      Cyst                                                                       2 (4%)       4 (8%)                                
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Nephropathy                                     42 (84%)     45 (90%)     47 (94%)     47 (94%)                               
      Pigmentation                                     1 (2%)       1 (2%)                                                          
      Renal Tubule, Degeneration                                                              1 (2%)                                
      Renal Tubule, Necrosis                           1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)       6 (12%)      1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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