Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14070

TDMS Study 88007-05 Pathology Tables

NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99
Route: DOSED WATER                                                                                                Time: 13:44:04

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7632-00-0

       Lock Date:  03/20/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            6           10           15                                     
    Natural Death                                      6           13            4            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           31           36           33                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)         (50)                                   
      Inflammation                                                               1 (2%)                                             
   Intestine Large, Colon                             (50)         (48)         (50)         (50)                                   
      Parasite Metazoan                                             1 (2%)       1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                             1 (2%)                                
      Parasite Metazoan                                4 (8%)       1 (2%)       2 (4%)       7 (14%)                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       3 (6%)       5 (10%)                               
      Basophilic Focus                                45 (90%)     42 (84%)     48 (96%)     45 (90%)                               
      Clear Cell Focus                                 9 (18%)      6 (12%)      8 (16%)      7 (14%)                               
      Cyst                                                                                    1 (2%)                                
      Eosinophilic Focus                               9 (18%)     10 (20%)      8 (16%)     10 (20%)                               
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                       4 (8%)      11 (22%)      7 (14%)      8 (16%)                               
      Inflammation, Chronic Active                    23 (46%)     23 (46%)     28 (56%)     28 (56%)                               
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)                                
      Mixed Cell Focus                                11 (22%)      3 (6%)       7 (14%)      9 (18%)                               
      Necrosis                                         5 (10%)      2 (4%)                    4 (8%)                                
      Pigmentation, Lipofuscin                                                   1 (2%)                                             
      Regeneration                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)       5 (10%)      4 (8%)       4 (8%)                                
      Bile Duct, Hyperplasia                           8 (16%)      4 (8%)       4 (8%)       4 (8%)                                
   Mesentery                                          (7)          (5)          (7)          (4)                                    
      Fat, Inflammation, Chronic Active                6 (86%)      5 (100%)     7 (100%)     4 (100%)                              
      Fat, Necrosis                                    1 (14%)                                                                      
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Acinus, Atrophy                                  6 (12%)      6 (12%)      8 (16%)      8 (16%)                               
      Acinus, Hyperplasia                              1 (2%)                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)       2 (4%)       2 (4%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Ulcer                                            4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Epithelium, Hyperplasia                          8 (16%)      6 (12%)      8 (16%)     40 (80%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Mineralization                                                2 (4%)                                                          
   Heart                                              (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       4 (8%)       3 (6%)       3 (6%)                                
      Mineralization                                                2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Angiectasis                                     40 (80%)     39 (78%)     45 (90%)     45 (90%)                               
      Degeneration                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                     15 (30%)     11 (22%)     11 (22%)     10 (20%)                               
      Hypertrophy                                      8 (16%)      7 (14%)      7 (14%)      4 (8%)                                
      Necrosis                                         2 (4%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                        4 (8%)       5 (10%)      1 (2%)       3 (6%)                                
   Adrenal Medulla                                    (50)         (50)         (45)         (49)                                   
      Hyperplasia                                      6 (12%)      7 (14%)      4 (9%)       5 (10%)                               
      Bilateral, Hyperplasia                                                     1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Hemorrhage                                       3 (6%)                                                                       
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Pars Distalis, Angiectasis                       2 (4%)                                                                       
      Pars Distalis, Cyst                              4 (8%)      10 (20%)      5 (10%)      9 (18%)                               
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     10 (20%)     19 (38%)     12 (24%)                               
      Pars Intermedia, Cyst                                                                   1 (2%)                                
   Thyroid Gland                                      (50)         (49)         (48)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ultimobranchial Cyst                             1 (2%)                    1 (2%)       4 (8%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Bilateral, C-Cell, Hyperplasia                                1 (2%)                                                          
      C-Cell, Hyperplasia                             24 (48%)     26 (53%)     34 (71%)     26 (52%)                               
      Follicle, Cyst                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (49)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             9 (20%)      1 (2%)      12 (24%)      3 (6%)                                
      Hyperplasia                                      8 (17%)      4 (8%)       7 (14%)      7 (14%)                               
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Cyst                                             4 (8%)       4 (8%)       3 (6%)       5 (10%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Follicle, Cyst                                   1 (2%)                    2 (4%)       2 (4%)                                
      Periovarian Tissue, Cyst                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)                                                          
      Dysplasia                                                                               1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       2 (4%)       1 (2%)                                
      Hydrometra                                       3 (6%)       4 (8%)       4 (8%)       5 (10%)                               
      Inflammation, Chronic Active                                               1 (2%)                                             
      Thrombosis                                                                 2 (4%)       1 (2%)                                
      Cervix, Hydrometra                                                         1 (2%)                                             
      Cervix, Hyperplasia                                                                     1 (2%)                                
      Cervix, Hypertrophy                              1 (2%)                                                                       
      Cervix, Epithelium, Cyst                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
      Myelofibrosis                                                              1 (2%)                                             
   Lymph Node                                         (2)          (1)          (2)          (1)                                    
      Ectasia                                                                                 1 (100%)                              
   Lymph Node, Mandibular                             (49)         (49)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       1 (2%)                    2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Pigmentation, Lipofuscin                                      1 (2%)       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
      Lymphoid Follicle, Depletion Cellular                                                   1 (2%)                                
   Thymus                                             (49)         (47)         (49)         (48)                                   
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Galactocele                                     14 (28%)     10 (20%)     12 (24%)     10 (20%)                               
      Hyperplasia                                     10 (20%)      5 (10%)      3 (6%)       9 (18%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                                                                   2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosclerosis                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                                              1 (2%)       1 (2%)                                
      Mineralization                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                    16 (32%)     13 (26%)     14 (28%)     17 (34%)                               
      Pigmentation                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                10 (20%)     10 (20%)      8 (16%)      3 (6%)                                
      Bronchiole, Epithelium, Hyperplasia              1 (2%)                    1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            3 (6%)                                
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)          (3)                                    
      Inflammation, Chronic Active                                  1 (100%)                                                        
      Cornea, Inflammation, Chronic Active                                                    1 (33%)                               
      Lens, Mineralization                                                                    1 (33%)                               
      Retina, Degeneration                                                       1 (100%)     3 (100%)                              
   Harderian Gland                                                                           (1)                                    
      Inflammation, Chronic Active                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Accumulation, Hyaline Droplet                                 1 (2%)                                                          
      Casts Protein                                                                           1 (2%)                                
      Cyst                                                                       2 (4%)       4 (8%)                                
      Infarct                                          1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       5 (10%)      4 (8%)       5 (10%)                               
      Mineralization                                   1 (2%)       1 (2%)       2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
      Nephropathy                                     14 (28%)     16 (32%)     20 (40%)     23 (46%)                               
      Pigmentation                                     2 (4%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Regeneration                                    1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       2 (4%)       5 (10%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16            4           12            8                                     
    Natural Death                                      5            8            2            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           37           36           36                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                5 (10%)      4 (8%)       3 (6%)       2 (4%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Congestion                                       1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   2 (4%)       3 (6%)       1 (2%)                                
      Basophilic Focus                                31 (62%)     34 (68%)     37 (74%)     42 (84%)                               
      Clear Cell Focus                                19 (38%)     25 (50%)     26 (52%)     23 (46%)                               
      Cyst                                                                                    1 (2%)                                
      Degeneration                                     1 (2%)                                                                       
      Degeneration, Cystic                             5 (10%)     15 (30%)     12 (24%)      4 (8%)                                
      Eosinophilic Focus                               4 (8%)      10 (20%)     11 (22%)      6 (12%)                               
      Fibrosis                                         2 (4%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                      11 (22%)      6 (12%)      4 (8%)       8 (16%)                               
      Inflammation, Chronic Active                    13 (26%)     19 (38%)     25 (50%)     24 (48%)                               
      Mixed Cell Focus                                 7 (14%)      7 (14%)      4 (8%)       2 (4%)                                
      Necrosis                                         5 (10%)      2 (4%)       1 (2%)       4 (8%)                                
      Regeneration                                     1 (2%)       1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                        8 (16%)      5 (10%)      4 (8%)       1 (2%)                                
      Bile Duct, Hyperplasia                          41 (82%)     38 (76%)     43 (86%)     38 (76%)                               
   Mesentery                                          (11)         (7)          (5)          (8)                                    
      Fat, Inflammation, Chronic Active                8 (73%)      5 (71%)      5 (100%)     6 (75%)                               
      Fat, Mineralization                              1 (9%)                                                                       
      Fat, Necrosis                                                              1 (20%)                                            
   Oral Mucosa                                        (2)                       (1)                                                 
      Pharyngeal, Cyst                                 1 (50%)                                                                      
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Atrophy                                 16 (32%)     27 (54%)     22 (44%)     28 (57%)                               
      Acinus, Hyperplasia                              4 (8%)       3 (6%)       6 (12%)      8 (16%)                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                                       1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)                    1 (2%)       1 (2%)                                
      Erosion                                          2 (4%)                                                                       
      Hyperkeratosis                                                1 (2%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                                             1 (2%)       1 (2%)                                
      Ulcer                                            4 (8%)       1 (2%)       2 (4%)       1 (2%)                                
      Epithelium, Hyperplasia                         12 (24%)      9 (18%)     10 (20%)     44 (88%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                          1 (2%)                    3 (6%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Ulcer                                            2 (4%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Tongue                                                                       (1)                                                 
      Epithelium, Hyperplasia                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     9 (18%)     15 (30%)     16 (32%)     12 (24%)                               
      Thrombosis                                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Angiectasis                                     16 (32%)     21 (42%)     15 (30%)     22 (44%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                     11 (22%)     15 (30%)     15 (30%)     10 (20%)                               
      Hypertrophy                                      7 (14%)      7 (14%)      2 (4%)       9 (18%)                               
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic                        3 (6%)       3 (6%)       8 (16%)      3 (6%)                                
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 (22%)     18 (36%)     16 (32%)     13 (26%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                                          2 (4%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Pigmentation, Hemosiderin                                                  1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                                    1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      9 (18%)     18 (36%)     10 (20%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                             11 (22%)     17 (34%)     16 (32%)     13 (26%)                               
      Follicle, Cyst                                                3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (1)                                                 
      Inflammation, Chronic Active                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Degeneration                                     1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)       1 (2%)       1 (2%)       3 (6%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                     8 (16%)     10 (20%)      6 (12%)      1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                         34 (68%)     34 (68%)     36 (72%)     33 (67%)                               
      Cyst                                                                       1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Degeneration                                     8 (16%)     12 (24%)     11 (22%)     11 (22%)                               
      Mineralization                                   7 (14%)      1 (2%)       2 (4%)       2 (4%)                                
      Interstitial Cell, Hyperplasia                   9 (18%)      6 (12%)      9 (18%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Myelofibrosis                                    1 (2%)                    3 (6%)                                             
   Lymph Node                                         (5)          (4)          (4)          (2)                                    
      Ectasia                                                                    1 (25%)                                            
      Pancreatic, Ectasia                              1 (20%)                                                                      
   Lymph Node, Mandibular                             (48)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                                 1 (2%)                                
      Hyperplasia                                      1 (2%)                    1 (2%)       2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                                    1 (2%)       1 (2%)                                             
      Ectasia                                                                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Pigmentation, Lipofuscin                         1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 1 (2%)                    1 (2%)                                             
      Congestion                                       2 (4%)       3 (6%)                                                          
      Fibrosis                                         2 (4%)       2 (4%)       3 (6%)       4 (8%)                                
      Hematopoietic Cell Proliferation                 5 (10%)                   2 (4%)       1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Histiocytic                                      1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)       1 (2%)                                
      Capsule, Fibrosis                                             1 (2%)                                                          
      Lymphoid Follicle, Depletion Cellular                         1 (2%)                                                          
   Thymus                                             (50)         (49)         (49)         (48)                                   
      Atrophy                                                       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (47)         (47)         (47)                                   
      Cyst                                                          1 (2%)                                                          
      Galactocele                                                   2 (4%)                    1 (2%)                                
      Hyperplasia                                      4 (9%)       6 (13%)      4 (9%)       3 (6%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Acanthosis                                                                 1 (2%)                                             
      Hyperkeratosis                                                1 (2%)       1 (2%)                                             
      Hyperplasia, Basal Cell                          1 (2%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Epidermis, Cyst                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hydrocephalus                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88007-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:44:04  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                                 1 (2%)       2 (4%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                    18 (36%)      7 (14%)     11 (22%)     11 (22%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Parasite Metazoan                                             1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                11 (22%)     11 (22%)     20 (40%)     14 (28%)                               
      Bronchiole, Epithelium, Hyperplasia                                                     1 (2%)                                
      Bronchus, Inflammation, Suppurative              1 (2%)                                                                       
      Interstitium, Fibrosis                                                     1 (2%)       1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)          (2)                                    
      Hemorrhage                                                                 1 (100%)                                           
      Lens Capsule, Mineralization                                                            1 (50%)                               
      Retina, Degeneration                                                                    2 (100%)                              
      Retrobulbar, Inflammation, Chronic Active                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Crystals                                                                                1 (2%)                                
      Cyst                                                                       2 (4%)       4 (8%)                                
      Infarct                                          1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Nephropathy                                     42 (84%)     45 (90%)     47 (94%)     47 (94%)                               
      Pigmentation                                     1 (2%)       1 (2%)                                                          
      Renal Tubule, Degeneration                                                              1 (2%)                                
      Renal Tubule, Necrosis                           1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)       6 (12%)      1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------