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TDMS Study 88007-05 Pathology Tables

NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99
Route: DOSED WATER                                                                                                Time: 13:52:35

                                                    FINAL #1 CORE STUDY RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7632-00-0

       Lock Date:  03/20/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            6           10           15                                     
    Natural Death                                      6           13            4            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           31           36           33                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Fibroma                                                                    1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (44)         (49)         (50)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
   Oral Mucosa                                        (1)          (1)                                                              
      Squamous Cell Carcinoma                          1 (100%)     1 (100%)                                                        
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Tongue                                                          (2)          (1)                                                 
      Squamous Cell Carcinoma                                       1 (50%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (49)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (45)         (49)                                   
      Pheochromocytoma Benign                          4 (8%)       2 (4%)                    2 (4%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          24 (48%)     25 (50%)     17 (34%)     21 (42%)                               
   Thyroid Gland                                      (50)         (49)         (48)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
      C-Cell, Adenoma                                  7 (14%)      4 (8%)      10 (21%)      6 (12%)                               
      C-Cell, Carcinoma                                2 (4%)                                 1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (49)         (49)                                   
      Adenoma                                          8 (17%)      8 (17%)      5 (10%)      3 (6%)                                
      Carcinoma                                        2 (4%)       1 (2%)                    1 (2%)                                
      Bilateral, Adenoma                                            2 (4%)       1 (2%)                                             
   Ovary                                              (50)         (49)         (50)         (50)                                   
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Schwannoma Malignant                                                       1 (2%)                                             
      Sertoli Cell Tumor Malignant                                               1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenocarcinoma                                   2 (4%)                                                                       
      Adenoma                                                       1 (2%)                                                          
      Polyp Stromal                                    7 (14%)      3 (6%)       8 (16%)      7 (14%)                               
      Sarcoma Stromal                                                            1 (2%)                                             
      Cervix, Carcinoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (2)          (1)          (2)          (1)                                    
      Carcinoma, Metastatic, Lung                                                1 (50%)                                            
      Mediastinal, Carcinoma, Metastatic, Adrenal                                                                                   
          Cortex                                                    1 (100%)                                                        
   Lymph Node, Mandibular                             (49)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (49)         (47)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)                    3 (6%)                                
      Adenoma, Multiple                                1 (2%)                                                                       
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Fibroadenoma                                    14 (28%)     14 (28%)     18 (36%)     20 (40%)                               
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Fibroadenoma, Multiple                           7 (14%)     13 (26%)     13 (26%)      5 (10%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Basal Cell Carcinoma                             1 (2%)                                 1 (2%)                                
      Fibroma                                          1 (2%)                    1 (2%)       1 (2%)                                
      Fibrosarcoma                                                                            1 (2%)                                
      Hemangiopericytoma                               1 (2%)                                                                       
      Lipoma                                                                     2 (4%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                 1 (2%)                                
      Trichoepithelioma                                1 (2%)                                                                       
      Pinna, Melanoma Malignant                                     1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
   Spinal Cord                                                                  (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (2)          (2)                                    
      Carcinoma                                                                  1 (50%)      1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Nephroblastoma                                                             1 (2%)                                             
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            15 (30%)     10 (20%)      1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          45          49          45                                       
     Total Primary Neoplasms                          107          94          95          87                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          42          46          42                                       
     Total Benign Neoplasms                            81          77          82          75                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          16          12          12                                       
     Total Malignant Neoplasms                         26          17          13          12                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1           2                                       
     Total Metastatic Neoplasm                                      2           1           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16            4           12            8                                     
    Natural Death                                      5            8            2            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           37           36           36                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                                          1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
   Intestine Small, Duodenum                          (49)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (50)         (48)         (50)         (49)                                   
   Intestine Small, Ileum                             (50)         (49)         (50)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Mesentery                                          (11)         (7)          (5)          (8)                                    
      Fat, Leiomyosarcoma, Metastatic, Intestine                                                                                    
          Large, Colon                                                                        1 (13%)                               
      Fat, Sarcoma                                                  1 (14%)                                                         
   Oral Mucosa                                        (2)                       (1)                                                 
      Pharyngeal, Squamous Cell Carcinoma                                        1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Acinus, Adenocarcinoma                                        2 (4%)                                                          
      Acinus, Adenoma                                                            1 (2%)                                             
      Acinus, Carcinoma                                             1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Carcinoid Tumor Benign                                                     1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                    1 (2%)                                
      Pheochromocytoma Benign                          5 (10%)     10 (20%)      6 (12%)      9 (18%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          4 (8%)                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                 2 (4%)                                
   Parathyroid Gland                                  (45)         (48)         (49)         (48)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Sarcoma NOS                                                                             1 (2%)                                
      Pars Distalis, Adenoma                          13 (26%)     13 (27%)     15 (30%)     10 (20%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                 12 (24%)      8 (16%)      7 (14%)      4 (8%)                                
      C-Cell, Adenoma, Multiple                                                               1 (2%)                                
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                                       3 (6%)       1 (2%)       2 (4%)                                
      Carcinoma                                        5 (10%)      1 (2%)       7 (14%)      5 (10%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     44 (88%)     38 (76%)     40 (80%)                               
      Interstitial Cell, Adenoma                      10 (20%)      2 (4%)       9 (18%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (5)          (4)          (4)          (2)                                    
      Carcinoma, Metastatic, Thyroid Gland             1 (20%)                                                                      
      Deep Cervical, Histiocytic Sarcoma                            1 (25%)                                                         
      Pancreatic, Sarcoma, Metastatic, Uncertain                                                                                    
          Primary Site                                                                        1 (50%)                               
   Lymph Node, Mandibular                             (48)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibroma                                                                                 1 (2%)                                
      Fibrosarcoma                                                  1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Thymus                                             (50)         (49)         (49)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (47)         (47)         (47)                                   
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     3 (7%)       5 (11%)      2 (4%)                                             
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (49)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Fibroma                                                       1 (2%)       5 (10%)      3 (6%)                                
      Fibroma, Multiple                                                          1 (2%)                                             
      Fibrosarcoma                                     1 (2%)                                 2 (4%)                                
      Keratoacanthoma                                  2 (4%)       3 (6%)       4 (8%)       3 (6%)                                
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma, Multiple                                                               1 (2%)                                
      Lipoma                                           1 (2%)                                                                       
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                                            1 (2%)                                
      Maxilla, Osteosarcoma                            1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                    (1)                                    
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Schwannoma Malignant, Metastatic, Heart          1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                                              
      Histiocytic Sarcoma                                           1 (50%)                                                         
   Zymbal's Gland                                     (1)                                    (2)                                    
      Carcinoma                                        1 (100%)                               2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Leukemia Mononuclear                            17 (34%)     12 (24%)      7 (14%)      3 (6%)                                
      Lymphoma Malignant                                            1 (2%)                                                          
      Mesothelioma Malignant                           3 (6%)       3 (6%)       4 (8%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  11                                                               
NTP Experiment-Test: 88007-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 10/18/99  
Route: DOSED WATER                                                                                                Time: 13:52:35  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.075%       0.15%        0.30%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          50          50                                       
     Total Primary Neoplasms                          129         120         123         107                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          48          49          49                                       
     Total Benign Neoplasms                            93          94          99          86                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          22          21          20                                       
     Total Malignant Neoplasms                         36          26          24          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                   2                                       
     Total Metastatic Neoplasm                          6                                  11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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