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TDMS Study 88007-06 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                  SODIUM NITRITE                                            DATE: 05/13/99    
EXPERIMENT: 88007 TEST: 06                                                                                        TIME: 09:30:12    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C88007      
CONT: NO1-ES-55384                                                                                                CAS: 7632-00-0    
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     SODIUM NITRITE                                              DATE: 05/13/99


EXPERIMENT: 88007 TEST: 06                                                                                        TIME:  9:36:35



TEST TYPE: TWO YEAR                                 ROUTE: DOSED WATER                                            NTP:  C88007

CONT: NO1-ES-55384                                                                                                CAS: 7632-00-0

                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
                               TWO YEAR DOSED WATER STUDY OF SODIUM NITRITE

==========================================================================================================
WEEK     0.0%                   0.075%                   0.15%                    0.30%
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        22.6       50        22.7    100.4    50      22.6    100.0    50      22.6    100.0    50
  1        22.6       50        22.7    100.4    50      22.6    100.0    50      22.6    100.0    50
  2        23.7       50        23.7    100.0    50      23.6     99.6    50      23.4     98.7    50
  6        29.5       50        29.6    100.3    50      29.1     98.6    50      28.3     95.9    50
 10        34.9       50        34.5     98.9    50      33.7     96.6    50      32.7     93.7    50
 14        39.1       50        38.9     99.5    50      37.7     96.4    50      36.2     92.6    50
 18        43.2       50        42.9     99.3    50      41.9     97.0    50      40.2     93.1    50
 22        45.6       50        44.9     98.5    50      44.0     96.5    50      42.1     92.3    50
 26        47.5       50        46.6     98.1    50      45.7     96.2    50      44.6     93.9    50
 30        49.6       50        48.9     98.6    50      48.3     97.4    50      46.9     94.6    50
 34        50.8       50        50.1     98.6    50      49.2     96.9    50      48.4     95.3    50
 38        50.6       50        49.7     98.2    50      48.7     96.2    50      48.1     95.1    50
 42        50.9       50        49.9     98.0    50      48.4     95.1    50      48.6     95.5    50
 46        50.8       50        49.4     97.2    50      48.3     95.1    50      48.6     95.7    50
 50        50.3       50        49.0     97.4    50      48.0     95.4    50      48.3     96.0    50
 54        51.3       50        50.5     98.4    50      49.2     95.9    50      49.5     96.5    50
 58        51.1       50        49.6     97.1    50      49.3     96.5    50      49.8     97.5    50
 62        51.4       50        50.4     98.1    50      49.4     96.1    50      49.5     96.3    50
 66        50.7       50        49.8     98.2    49      49.0     96.6    50      48.8     96.3    50
 70        50.0       50        49.7     99.4    49      48.8     97.6    50      48.7     97.4    49
 73        49.4       49        49.5    100.2    49      48.8     98.8    50      48.1     97.4    48
 78        49.4       48        49.1     99.4    49      48.2     97.6    50      47.6     96.4    48
 82        48.7       48        48.4     99.4    49      48.2     99.0    50      46.6     95.7    46
 86        47.2       48        46.9     99.4    49      46.8     99.2    48      45.4     96.2    44
 90        46.4       47        46.4    100.0    47      46.1     99.4    48      44.7     96.3    44
 94        44.7       45        44.4     99.3    45      44.5     99.6    45      44.1     98.7    43
 98        43.0       43        43.7    101.6    45      43.6    101.4    43      42.8     99.5    41
102        40.2       40        41.3    102.7    45      41.4    103.0    42      41.0    102.0    39

TERM. SAC.            39                         45                       42                       39


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
                               TWO YEAR DOSED WATER STUDY OF SODIUM NITRITE

==========================================================================================================
WEEK     0.0%                   0.075%                   0.15%                    0.30%
         ----------------       ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
=========================================================================================================

  B        18.9       50        18.9    100.0    50      18.8     99.5    50      18.9    100.0    50
  1        18.9       50        18.9    100.0    50      18.8     99.5    50      18.9    100.0    50
  2        19.4       50        19.7    101.5    50      19.5    100.5    50      19.4    100.0    50
  6        23.7       50        23.9    100.8    50      23.9    100.8    50      23.2     97.9    50
 10        28.2       50        28.4    100.7    50      28.2    100.0    50      26.9     95.4    50
 14        31.4       50        32.6    103.8    50      31.5    100.3    50      30.3     96.5    50
 18        35.6       50        37.8    106.2    50      36.5    102.5    50      34.4     96.6    50
 22        40.0       50        41.7    104.3    50      40.6    101.5    50      38.2     95.5    50
 26        43.2       50        44.9    103.9    50      43.7    101.2    50      41.1     95.1    50
 30        46.6       50        47.4    101.7    50      46.2     99.1    50      43.3     92.9    50
 34        49.2       50        49.6    100.8    50      48.8     99.2    50      45.4     92.3    50
 38        51.1       50        51.1    100.0    50      50.0     97.8    50      46.9     91.8    50
 42        53.4       50        53.3     99.8    50      52.3     97.9    50      48.8     91.4    50
 46        54.2       50        54.6    100.7    50      54.0     99.6    50      50.8     93.7    50
 50        55.3       50        55.6    100.5    50      54.8     99.1    50      52.5     94.9    50
 54        56.1       50        55.3     98.6    50      55.2     98.4    50      53.0     94.5    50
 58        56.7       50        57.0    100.5    50      56.6     99.8    50      54.2     95.6    50
 62        58.8       50        58.2     99.0    50      58.4     99.3    50      56.1     95.4    49
 66        58.3       49        57.5     98.6    50      57.4     98.5    50      55.4     95.0    49
 70        57.7       49        56.8     98.4    49      56.5     97.9    49      54.4     94.3    48
 73        56.1       49        56.1    100.0    49      55.0     98.0    49      53.7     95.7    48
 78        55.5       49        56.3    101.4    49      55.0     99.1    48      53.8     96.9    47
 82        55.0       47        55.6    101.1    49      54.2     98.5    48      54.2     98.5    46
 86        53.5       45        53.7    100.4    49      53.5    100.0    48      53.2     99.4    46
 90        52.6       43        52.8    100.4    48      53.1    101.0    45      51.2     97.3    46
 94        52.1       42        52.1    100.0    43      52.3    100.4    45      49.6     95.2    46
 98        52.0       41        51.4     98.8    37      51.4     98.8    44      49.3     94.8    44
102        51.1       41        50.7     99.2    35      50.7     99.2    41      48.9     95.7    41

TERM. SAC.            40                         34                       37                       41


==========================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.