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TDMS Study 88007-06 Pathology Tables

NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99
Route: DOSED WATER                                                                                                Time: 09:43:12

                                                      2 YEAR CHRONIC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7632-00-0

       Lock Date:  03/20/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2|             
                                           | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |    3                                                                     |             
      Epithelium, Ulcer                    |    4                                                                     |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                 4                        |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              X                 X     X   |             
      Clear Cell Focus                     |                                                                X         |             
      Eosinophilic Focus                   |       X        X                             X           X              X|             
      Hematopoietic Cell Proliferation     | 1                                                                        |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1  1  1  1        1        1  1  1        1  1     1  1  1  1|             
      Inflammation, Chronic Active         | 1  3  1     1  1  1  1           1        1  1        2  1     1  1  1  1|             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             | 1                                                     2                  |             
      Pigmentation                         | 2     1                          1                                   1  1|             
      Vacuolization Cytoplasmic            |                                              1     4  2                  |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Centrilobular,           |                                                                          |             
          Hypertrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +              +           +  +     +  +           +        +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Necrosis                        |                                     4  4     4  4                    4  4|             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                   +      |             
      Gingival, Foreign Body               |                                                                   X      |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                   1      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             2                             1           1  1     1  1      |             
      Acinus, Atrophy                      |             2                                                            |             
      Duct, Cyst                           |             3                                                            |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2|             
                                           | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Cell                             |                1  1  1        1  1  1     1  1        1  1     1  1  1   |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                3                                                         |             
      Epithelium, Hyperplasia              |                3                 2                                       |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |                2           2                                             |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    2                     |             
      Glands, Ectasia                      | 1     1  1  1     1                    1              1  1     1  1      |             

                                            __________________________________________________________________________|             
   Tongue                                  |                         M                                                |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                    4                     |             
      Pulmonary Artery, Mineralization     |                                                    4                     |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Mineralization                       |                                                    1                     |             
      Valve, Inflammation, Chronic Active  |    2                                                                     |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   2                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Hyperplasia                 | 2  1  2  2  2  2  2  1  2  1  2  2     2  2  2  1  2  2  2  2  2  2  2  2|             
      Zona Fasciculata, Hypertrophy        |       1                                                                  |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  2  2     2  2  2  2  2  1        2  2  2  2  2  2  2  2  2  2  2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  +  +  M  +  M  +  M  +  M  +  +  +  +  +  +  +  M  M  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 2     1  1        1                       1                              |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2|             
                                           | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                              2                           |             
      Duct, Cyst                           |    2                                                                     |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                       2                                2               |             
      Hemorrhage                           | 4                                   4                                    |             
      Mineralization                       | 2     2                             2                                    |             
      Thrombosis                           | 3                                   4                                    |             

                                            __________________________________________________________________________|             
   Oviduct                                 |                                           +                              |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    2  4  4  3  3  3  2  2     2  3        3  2  3     3  2           3  2|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2           2  2     2                    2        1        2  2  2      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +              +                       +  +                     |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |    4                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               4                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          3               |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4        1  3  1  1  2  4     2  2        2  1  3  3  2  2     2  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Cyst                                 |    2  1              2           2                       2               |             
      Ectopic Parathyroid Gland            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                               1                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Ulcer                                |    4                                                                     |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +  +                 +                                                |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 8| 2| 2| 2| 3| 2| 2| 6| 6| 2| 3| 4| 3| 3| 2| 3| 8| 2| 3| 2| 2| 3| 2| 2|             
                                           | 6| 0| 8| 9| 9| 0| 9| 9| 3| 5| 9| 0| 7| 0| 0| 9| 1| 6| 9| 0| 2| 9| 0| 8| 9|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    2                                                                     |             
      Hemorrhage                           |    1                                                                     |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic Active         |                   1                                                  1   |             
      Bronchus, Mineralization             |                                                    2                     |             
      Vein, Mineralization                 |                                                    2                     |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                   2                                                      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1  1     1     1  1     1  1  1  1        1  1     1  1  1  1|             
      Inflammation, Suppurative            |                            2                                             |             
      Mineralization                       |                1  1              1                 3                     |             
      Nephropathy                          |    1        1     1  1                                1                 1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1  1  1  1        1  1  1  1     1        1  1     1  1  1  1|             
      Inflammation, Chronic Active         |                            2                                             |             
      Mineralization                       |                            2                                             |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3|            |
                                           | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Epithelium, Ulcer                    |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                            X                                             |      2     |
      Eosinophilic Focus                   |                                                       X           X      |      7     |
      Hematopoietic Cell Proliferation     |                         2                                                |      2  1.5|
      Hemorrhage                           |          2                                                               |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  2        1  1     1  2  1     1     1        1     1     1  1  1  1  1|     30  1.1|
      Inflammation, Chronic Active         | 1  1  1     1  1     1     1     2  1  1  2  2  1     1  1  1  1  2  1  1|     36  1.2|
      Mineralization                       |                                                                1         |      1  1.0|
      Mixed Cell Focus                     |                                                    X                 X   |      3     |
      Necrosis                             |                                           2                 1     1      |      5  1.4|
      Pigmentation                         |                      1              1     2  1     1        1  1         |     12  1.2|
      Vacuolization Cytoplasmic            |          2  1  2  3  2                                         1     1   |     10  1.9|
      Bile Duct, Hyperplasia               |    1                                                                     |      1  1.0|
      Hepatocyte, Centrilobular,           |                                                                          |            |
          Hypertrophy                      |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                   +              +     +     +|  14        |
      Inflammation, Granulomatous          |                                              4                           |      1  4.0|
      Fat, Necrosis                        |          4                                                  4     3     4|     10  3.9|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Gingival, Foreign Body               |                                                                          |      1     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3|            |
                                           | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Cell                             | 1  1        1  1     1           2           1  1                        |     14  1.1|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1        1  1  1  2  1  1     1  1  1  1  1  1  1  1  1  1  1     1  1|     34  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      2  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Glands, Ectasia                      |             1                    1        1  1  1  1  1     1           1|     19  1.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Mineralization                |                         1                                                |      2  2.5|
      Pulmonary Artery, Mineralization     |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                  1                                       |      1  1.0|
      Mineralization                       |                                                                          |      1  1.0|
      Valve, Inflammation, Chronic Active  |                               4                                          |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Capsule, Hyperplasia                 | 2  2  1  2  2  2  1  2  2  2  1  2  1  2  2  2  2  2  2  2  2  2  2  2  2|     49  1.8|
      Zona Fasciculata, Hypertrophy        |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  1  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  3  2  2  2  2|     45  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +|  33        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Pars Distalis, Angiectasis           |          2                                                               |      1  2.0|
      Pars Distalis, Hyperplasia           |       2                                1                                 |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3|            |
                                           | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                         1|      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                      1                       1                           |      7  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                2                                            2        2   |      6  2.3|
      Hemorrhage                           |                                                                          |      2  4.0|
      Mineralization                       |                                                                          |      3  2.0|
      Thrombosis                           |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           | 2     3  4        4  2           2  2  3  3  3        4  4  2  2  2      |     32  2.8|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                      2                                                  1|      2  1.5|
      Inflammation, Suppurative            |                         3                                                |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |             2                                   2  2                 2   |     13  1.9|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                         3              3                                 |      2  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                             +                                       |   7        |
      Renal, Ectasia                       |    3                                                                     |      1  3.0|
      Renal, Hemorrhage                    |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2  2  2  1     2  3  2  3  1  2     3  2  2  2  2     1     2     2      |     37  2.1|
      Hyperplasia, Lymphoid                |    3     3                       3        3                              |      4  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3|            |
                                           | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |    2                       1  1                       1        1         |     10  1.5|
      Ectopic Parathyroid Gland            |                                                             1            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                    3           2         |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration                         |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                      2                                                   |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Bronchus, Mineralization             |                                                                          |      1  2.0|
      Vein, Mineralization                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                 2                        |      2  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1     1  1  1        1  1     1     1  1  1  1  1  1  1  1  1  1  1  1|     35  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 2| 5| 2| 2| 3| 1| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 2| 2| 2| 3|            |
                                           | 0| 0| 9| 9| 0| 9| 6| 9| 9| 0| 5| 0| 0| 9| 9| 0| 0| 0| 9| 0| 9| 9| 9| 8| 0|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                               1                                          |      5  1.4|
      Nephropathy                          |    1  1  1           1  3        1  3  1     1  1     1        1     1  1|     20  1.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  2     1              1  1  1  1                       2           2  1|     25  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6|             
                                           | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             1            |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                1           1                                             |             
      Epithelium, Cytoplasmic Alteration   |                      3                                                   |             
      Epithelium, Hyperplasia              |                      3                                                   |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Clear Cell Focus                     |                            X              X                              |             
      Eosinophilic Focus                   |                               X  X        X                              |             
      Hematopoietic Cell Proliferation     |             1        2                                         1        1|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1        1                 1     1     1     2  1  1  1     1     2|             
      Inflammation, Chronic Active         | 1  2  1        1     3  1  1  1  1  1  2  1  1        1  1  1     1      |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             |                                        2                             1   |             
      Pigmentation                         |       1     1        2           1        1                              |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |             2              1  2  1        1  2  4  2     2  1     2     1|             
      Bile Duct, Hyperplasia               |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               | +        +           +                          +           +        +  +|             
      Congestion                           |                                                                         1|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Thrombosis                           |                                                 4                        |             
      Fat, Necrosis                        | 4                                                                        |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1        1                          1              1               |             
      Inflammation, Chronic Active         |                      1                                                   |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  1     1  1        1  1  1     1  1  1        1     1  1  1  1     1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6|             
                                           | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                        2        2                        |             
      Epithelium, Hyperplasia              |                                        2        2                        |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                        2        2           1            |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      |    1  1        1        1        1        1  1     2                     |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1                                                   |             
      Inflammation, Chronic Active         |                                           2                              |             
      Mineralization                       |          1                                      1                        |             
      Artery, Mineralization               |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                1         |             
      Hematopoietic Cell Proliferation     |                      1                                         1         |             
      Inflammation, Chronic Active         |                      2                                                   |             
      Capsule, Hyperplasia                 | 2  2  1  2  2  2  1  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2|             
      Zona Fasciculata, Hypertrophy        |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                                                 2                        |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2  2  2  2     2  2  2  2  2  2  2     2     2  2  2  2  2  2     2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  M  +  M  M  M  +  +  +  +  M  M  +  M  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         2  3                                             |             
      Pars Distalis, Hyperplasia           |                         2  3                                             |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                        1                                 |             
      Inflammation, Suppurative            |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            2                                      2     2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6|             
                                           | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Adenomatous             |                                              2                           |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |       2        4  2  2  3  2  4  2           4  2     2     4     4      |             
      Endometrium, Hyperplasia, Cystic     | 2     2     2                          2                                1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                        3                       4         |             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +                                      +                    +   |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             2            |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  1     1  1     3  1  2  1  1  1  3  2  2  3  2        2  3  2     2|             
      Hyperplasia, Lymphoid                |                3     4                                   2               |             
      Metaplasia, Osseous                  |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       1        2     1                                                  1|             
      Ectopic Parathyroid Gland            |                      1  2                 1              1               |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2                                                        2         |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                         3         |             
      Ulcer                                |                                                                4         |             
      Epidermis, Hyperplasia               |                                                                2         |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                      1   |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 6| 6| 7| 6| 6|             
                             DAY ON TEST   | 3| 2| 3| 5| 2| 2| 8| 2| 2| 3| 2| 2| 2| 5| 2| 2| 6| 7| 0| 2| 8| 5| 3| 5| 6|             
                                           | 0| 9| 0| 1| 8| 9| 4| 8| 8| 0| 9| 9| 9| 2| 9| 9| 4| 3| 5| 9| 3| 9| 0| 0| 7|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 2     2                                                                  |             
      Inflammation, Chronic Active         |                      3           1                       1               |             
      Mineralization                       |                                                       1                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3     1              2                                                   |             
      Vein, Mineralization                 |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          1                                                               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                 2                        |             
      Infarct                              |                                  2     2        4              1         |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1        1     1     1  1     1  1  1  1     1  1  1  1  1  1     1|             
      Mineralization                       |                            1     1                                       |             
      Nephropathy                          |       1        1     1     1     1     1  1                              |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  1        2  1     1     1  1  1  1  1        1  1  1  1  1  1     1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                         1|      3  1.0|
      Epithelium, Cytoplasmic Alteration   |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                           X  X                          X|      4     |
      Clear Cell Focus                     |                            X                                             |      3     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Hematopoietic Cell Proliferation     |                                     1                                    |      5  1.2|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1     1  1  1        2           1  1  2  1  1  1  1  2  1  1  1|     32  1.2|
      Inflammation, Chronic Active         | 1     1  1  1  1  1  1        1              1  1  2  1  1  1  2  1  2  1|     35  1.2|
      Mineralization                       |                                                    1                     |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                  4                 2                     |      4  2.3|
      Pigmentation                         |    2           1  1  1  1  2     2                 2  1     1        1  1|     17  1.3|
      Thrombosis                           |                                                    3                     |      1  3.0|
      Vacuolization Cytoplasmic            |                                     2     2        1              2  1   |     17  1.7|
      Bile Duct, Hyperplasia               |                                                    2                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +           +     +  +     +     +              +  +        +  +  +|  19        |
      Congestion                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Fat, Necrosis                        |       4           4                                   4  4        4     4|      7  4.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1     1        1              2                 1        1|     10  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Duct, Cyst                           |                                  3                                       |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1     1  1  1  1  1  1  1  1  1  1     2  2        1  1  1  1  1  1  2|     36  1.1|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                 1                        |      1  1.0|
      Ulcer                                |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                         2                                                |      3  2.0|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      3  1.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Ectasia                      |       1  1           1           1                       1  1     1  1   |     16  1.1|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Artery, Mineralization               |                                                    2                     |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       2                                                                  |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 | 2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  1.9|
      Zona Fasciculata, Hypertrophy        |       2                                                                  |      1  2.0|
      Zona Glomerulosa, Hyperplasia        |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2     2  2  2  2  2  2|     44  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  +  +  +  +  +  M  +  M  +  M  M  M  +  +  M  +  +  +  +  +|  31        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           | 3                                                                        |      3  2.7|
      Pars Distalis, Hyperplasia           |                                  2                                       |      3  2.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Follicle, Cyst                       |                                                       1           2      |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                        +                                 |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                      1           1           1                           |      4  1.0|
      Inflammation, Suppurative            |                   1              1                                       |      2  1.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Cyst                                 | 2                 2           4  4                 3           2         |      9  2.6|
      Hemorrhage                           |                                  4                                       |      1  4.0|
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        3                                 |      1  3.0|
      Hydrometra                           | 2  2  3  2     3  4  4  4  2  3     3     3  3     2     2     2  3  2   |     31  2.8|
      Endometrium, Hyperplasia, Cystic     |                                  2                    3        2     2  2|     10  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                                        4                                 |      3  3.7|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                       +     +     +                                 |   7        |
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |    3                                                                     |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Plasma Cell             |                                                             3            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                                                      3   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1        1     1  1  1  2  2  1  1  2  4  1     1  2     2  1  2  1  2   |     39  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  47        |
      Cyst                                 | 1           1     2     2        1        2                 1     1      |     12  1.3|
      Ectopic Parathyroid Gland            |                                        1                                 |      5  1.2|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    2                                                                     |      3  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              1                           |      3  2.0|
      Ulcer                                |                                                                          |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                1         |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.0|
      Vein, Mineralization                 |                                                    1                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      4  2.3|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1     1  1  1  1  1  2     1  2           1  1  1  1  1  1     2  1  1  2|     37  1.1|
      Mineralization                       | 1        1  1  1                                            1           1|      8  1.0|
      Nephropathy                          | 1     1  1     1                       2  1     1  2  1           1      |     17  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 4| 3| 2| 0| 3| 2| 3| 2| 3| 3| 3| 5| 5| 2| 2| 2| 7| 0| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 3| 0| 8| 9| 0| 8| 0| 9| 0| 0| 0| 1| 9| 9| 8| 9| 3| 6| 0| 8| 0| 9| 9| 9|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1     2  1  1     1              1     1     1  1     1  1     2|     29  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3|             
                                           | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                   1      |             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                 X           X            |             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1              1                 1  1     1  1     2  1  1        1|             
      Inflammation, Chronic Active         |                      1        1  1           1  1  1     1  1  1     2  1|             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |                   2                    1  3                              |             
      Pigmentation                         |                1                                1        1           2  1|             
      Vacuolization Cytoplasmic            |    4              3  1  2           4  3     2  2                 1      |             
      Bile Duct, Cyst                      |                                  3                                       |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +        +     +  +     +  +                    +  +            |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Fat, Necrosis                        |                         4  4     4                       4  4            |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Foreign Body               |                                                                          |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                                          |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1              1  1                             1  1               |             
      Acinus, Hyperplasia                  |                                                 1                        |             
      Artery, Inflammation, Chronic Active |                                                                      1   |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1     1  1     2  1  1  1        1  1     2  1  2  1  2  1  1  1   |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     1     2                              |             
      Epithelium, Hyperplasia              |                                     2     2                              |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |                            1        1     2                              |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3|             
                                           | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                      2   |             
      Epithelium, Necrosis                 |                                     1                                    |             
      Glands, Ectasia                      |       1        1        1                       1  1                    1|             
      Glands, Necrosis                     |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                1                                                         |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              2                           |             
      Degeneration, Fatty                  |                                                                      2   |             
      Capsule, Hyperplasia                 | 2  2  1     2  2  1  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Zona Fasciculata, Hyperplasia        |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2        2     2  2     2     2  2  2  2  2  3  2  2     2  3     2|             
      Pigmentation                         |                                  2                                       |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  M|             
      Cyst                                 |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  M  +  +  +  +  I  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |             1                                      1                     |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  2                                       |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1        1     1        2     1  1     1                                 |             
      Inflammation, Suppurative            |                                  2                    3                  |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2  2  4                 2               |             
      Hemorrhage                           |                                        4                                 |             
      Thrombosis                           |                                        2                                 |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3|             
                                           | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |          4  2  4     4  2     4  3     2  2                       3  3  4|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    1                                         2  2     1  2  1            |             
      Submucosa, Hyperplasia, Stromal      |                                        2                                 |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                      1                                                   |             
      Myeloid Cell, Hyperplasia            |                               3                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +                 +  +                 +  +            |             
      Inguinal, Hyperplasia, Lymphoid      |                                                             2            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                          3  2            |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                        4                                 |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          3        3     2|             
      Hyperplasia, Plasma Cell             |                               3                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    3                     |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       1        1     2  2  4  3     3  3     1     1  3  2  1  2  1  3  2|             
      Hyperplasia, Lymphoid                |                                                    3     3               |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +|             
      Cyst                                 | 2     1     2                                                  1  1      |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               3                       3                  |             
      Ulcer                                |                               4                                          |             
      Epidermis, Hyperplasia               |                               3                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 6| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 8| 2| 1| 3| 2| 7| 2| 1| 2| 1| 9| 2| 2| 3| 3| 2| 2| 3| 3| 2| 3|             
                                           | 8| 7| 8| 6| 7| 9| 0| 0| 8| 7| 8| 6| 4| 6| 1| 9| 9| 0| 0| 8| 9| 0| 0| 8| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  3                                       |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1           2                                   1        1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3                                                                        |             
      Vein, Mineralization                 |                                  1                                       |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Cataract                             |                               2                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                         2                                                |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1        1     1  1     1  1     1  1  1  1  1  1  1  1  1  1  2  1|             
      Mineralization                       | 1     1                                      1        1                  |             
      Nephropathy                          | 1           1  1                                                     3   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1                    1     2  1                 1  1  1  1  1  2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X                       X                                         X|      3     |
      Clear Cell Focus                     |                            X                                      X      |      3     |
      Eosinophilic Focus                   |                            X                          X                  |      4     |
      Hematopoietic Cell Proliferation     |                         1                                1               |      3  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1     1  1  1  1  1     1     1  1  1        1  1  1  1  1     1  1  1|     29  1.0|
      Inflammation, Chronic Active         | 1  1     1  1  1  1  1  1  1  1     1  1        1  1  1     1     1  1  1|     30  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      3  2.0|
      Pigmentation                         |       1     1     1  1              1  1        1  1  1     1           1|     16  1.1|
      Vacuolization Cytoplasmic            |                            1           1  1                              |     12  2.1|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +           +  +     +  +     +           +  +            |  17        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Pigmentation, Hemosiderin            |                1                                                         |      1  1.0|
      Fat, Necrosis                        |                4              2     4  4                    4            |     10  3.8|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                +                             +                           |   2        |
      Gingival, Foreign Body               |                X                             X                           |      2     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                1                             2                           |      2  1.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1                       1                                 |      7  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1  1  2  2  1  2  1     1     1  1     2  1  1     1  1  2  1  1|     40  1.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      2  1.5|
      Epithelium, Hyperplasia              |          2                                                               |      3  2.0|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      3  1.3|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Epithelium, Necrosis                 |                                                                          |      1  1.0|
      Glands, Ectasia                      |                         1                       1     1                 1|     10  1.0|
      Glands, Necrosis                     |                      1                                                   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                          M               |            |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2|     49  1.9|
      Zona Fasciculata, Hyperplasia        |                                                       1                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2     3  2  2|     40  2.1|
      Pigmentation                         |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  +  M  M  M  I  +  M  +  +  M  +  M  +  +  M  +  M  +  +  +|  31        |
      Cyst                                 |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|  43        |
      Pars Distalis, Cyst                  |                                           1     1                        |      2  1.0|
      Pars Distalis, Hyperplasia           |                                                       2                 1|      4  1.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1  1  1        1     1        1                           |     13  1.1|
      Inflammation, Suppurative            |                                                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          2                 2  2                 2  2                     |      9  2.2|
      Hemorrhage                           |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           | 4  4  3     3     2  4  4  2  4     3  4  4  2  4  4  4  4  2  3  3  4   |     33  3.3|
      Inflammation, Suppurative            |       2                                                           2      |      2  2.0|
      Endometrium, Hyperplasia, Cystic     |          3     2        2  2  1  2        2     2           2           3|     16  1.9|
      Submucosa, Hyperplasia, Stromal      |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |    1                                                                     |      2  1.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                                      +   |   8        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                      3   |      3  2.7|
      Renal, Ectasia                       |                               4                                          |      1  4.0|
      Renal, Hemorrhage                    |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                         3                                               3|      5  2.8|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Ectasia                              |       4                    4                                             |      2  4.0|
      Fibrosis                             |                                     2                                    |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                      3   |      2  3.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1  1  1  1  1  3  1  1  2  2  1  1  3  2        1     2  4        3      |     35  1.9|
      Hyperplasia, Lymphoid                |                                                    4                 4   |      4  3.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Cyst                                 | 1     2  2        1  2        1  2  1  2  1  1     1                     |     17  1.4|
      Ectopic Parathyroid Gland            |          1                       1                                1      |      3  1.0|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  |                                                          M               |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                    1                     |      2  1.5|
      Mineralization                       |                                                                      1   |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                    3                     |      2  3.0|
      Vein, Mineralization                 |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                              3                           |      1  3.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |       2                                   1                              |      3  1.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 2| 1| 3| 2| 2| 3| 3| 2| 0| 2| 2| 3| 2| 2|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 8| 0| 0| 0| 9| 7| 0| 9| 3| 0| 0| 9| 6| 8| 1| 0| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cell                             |    1     2  1     1  1  1  1  1        1  1     1  1  1     1     1     1|     34  1.1|
      Mineralization                       |          1              1                                                |      6  1.0|
      Nephropathy                          |       1     1  2     1  1     1  1     2  1                              |     13  1.3|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1  1  1  1  1  1        1     1  1     1  1        1        1  1|     24  1.1|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3|             
                                           | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            1                                            1|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                    2                                          |             
      Basophilic Focus                     |                                                 X                        |             
      Clear Cell Focus                     |                                                                      X   |             
      Congestion                           |          2                                                               |             
      Eosinophilic Focus                   |    X     X                    X                                          |             
      Hematopoietic Cell Proliferation     |          1                    1           2           1                  |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  1  2  1  1           1  1  1  1     1     1  1  1     1  2  1  1   |             
      Inflammation, Chronic Active         |       1  1  1     1           1  1  1     1     1  1  1  2  1     1  1  1|             
      Necrosis                             |                                                                2         |             
      Pigmentation                         |          1        1           1     1        1  1     1        1  1      |             
      Vacuolization Cytoplasmic            |          1  2        4  3        1           2  2                        |             
      Bile Duct, Hyperplasia               |                                                                         1|             
      Centrilobular, Necrosis              |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +        +                 +  +                    +  +  +      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Artery, Inflammation, Chronic Active |          2                                                               |             
      Fat, Necrosis                        |                   4                 4                       4  4  4      |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +  +     +         |             
      Gingival, Foreign Body               |                                                       X  X     X         |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                          1     1         |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1     2     1           1     1                          1            |             
      Acinus, Atrophy                      |                                              3                           |             
      Acinus, Hypertrophy                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3|             
                                           | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                    2                           |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  2  1     1           1  1  1  1  1  1  1  2     1  1  1  1     1  1|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperkeratosis           |                                                                          |             
      Epithelium, Hyperplasia              |       2                                                           3  3   |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                           2                              |             
      Glands, Ectasia                      |       2  1        1           1              2        1  1        1  2   |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      1                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                   1      |             
      Degeneration, Fatty                  |             1                                   2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Hyperplasia                 |    2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Zona Fasciculata, Hyperplasia        |                                                                          |             
      Zona Glomerulosa, Hyperplasia        |                         1                                                |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2  2        2  2  2  2  2  2  2  2  2     2  2  2  2  2     2  2  2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  +  +  M  M  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            1     2                 2                     |             
      Pars Distalis, Cyst                  |                            1                                            1|             
      Pars Distalis, Hyperplasia           |                                  2  2              2                     |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3|             
                                           | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                1                                                         |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                     3  4                                 |             
      Hemorrhage                           |                                        4                                 |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    2     4  3  2           2     2  3     4  2  4  4  3  2  2  2  2  3  3|             
      Endometrium, Hyperplasia, Cystic     | 2     2  2  2  2              2        2                 2              3|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             
      Hyperplasia                          |    3                                                                     |             
      Myeloid Cell, Hyperplasia            |                                           4              4               |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                +     +           +                                       |             
      Inflammation, Granulomatous          |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                3                                                         |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                      1                                                   |             
      Mediastinal, Hyperplasia, Lymphoid   |                2                                                         |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hyperplasia, Lymphoid                |       3           3                                                  3   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Inflammation, Granulomatous          |                                                                2         |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  2  2        2        2  2  1  2  3  3     2  2  2  3  2  2  2  2  1|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Capsule, Inflammation, Chronic Active|          3                                                               |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |       1                 2  2              1        2              1     2|             
      Ectopic Parathyroid Gland            |          1                                                               |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3|             
                                           | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Mononuclear Cell       |                                                                      2   |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Synovial Tissue,         |                                                                          |             
          Inflammation, Chronic Active     |                2                                                         |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Inflammation, Chronic Active|                                                                          |             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Demyelination                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            2                                             |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             1                                                     3      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            3                                             |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                         2                                                |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                            1                                3        2   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1     1  1  1        1  1  1  1     1     1  1  1  1  1  1  1  1  1|             
      Infiltration Cellular, Plasma Cell   |          1                                                               |             
      Mineralization                       |                                     1  1                                 |             
      Nephropathy                          |          1        1  2     1  1  1  1  1     1  1  1     1  1        1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 2| 2| 8| 2| 2| 2| 3| 2| 7| 3| 5| 3| 2| 2| 3| 2| 3| 3| 2| 3|             
                                           | 4| 9| 9| 9| 9| 8| 8| 7| 0| 9| 8| 0| 8| 3| 0| 9| 0| 8| 9| 0| 8| 0| 0| 9| 0|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Vein, Inflammation, Chronic Active   |          2                                                               |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1  1  1     1     1        1                       1  1  2     1  1|             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0|            |
                                           | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1                       1                                 |      4  1.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                     4                                    |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |    X                                                                     |      2     |
      Congestion                           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                X                                         X               |      5     |
      Hematopoietic Cell Proliferation     |                                                                          |      4  1.3|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  2  1  1     1  1  1  1        1     1     1     1  1  1  1  1  1  2   |     35  1.1|
      Inflammation, Chronic Active         |    1  1  1  3  1  1  1  1     2  1  1  2  1  1     1  1     1     1  1   |     35  1.1|
      Necrosis                             |             2                                                            |      2  2.0|
      Pigmentation                         |          1  2        1        1     1     1                       1  1  2|     18  1.1|
      Vacuolization Cytoplasmic            |                      1                 1     1     2  3                 2|     13  1.9|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
      Centrilobular, Necrosis              |                                                 2                       3|      2  2.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                 2                        |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +     +        +           +           +  +|  13        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                         2|      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Necrosis                        |                               4     4        4           4           4  4|     11  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
      Gingival, Foreign Body               |                                                                          |      3     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      2  1.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0|            |
                                           | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1                          1     1  1                 1  2  1         |     13  1.2|
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Acinus, Hypertrophy                  |                                     2                                    |      1  2.0|
      Artery, Inflammation, Chronic Active |             3                                                            |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  2.5|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2  2  1  1     2  2  1  2  1  1  1  1  1           2     2  1           1|     35  1.3|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperkeratosis           |                                     3                                    |      1  3.0|
      Epithelium, Hyperplasia              |                                     3     2              2               |      6  2.5|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                     2                                    |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Glands, Ectasia                      | 1  2           1     1  1  1     1        2                 2  1  1  1   |     21  1.3|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |             2                                                            |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Degeneration, Fatty                  |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |             1                                                        1   |      2  1.0|
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  1|     49  2.0|
      Zona Fasciculata, Hyperplasia        |       1                                                                  |      1  1.0|
      Zona Glomerulosa, Hyperplasia        |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2     2  2     2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2|     42  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  37        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                          |      3  1.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0|            |
                                           | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           |    1  2                                                           1      |      6  1.7|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
      Follicle, Cyst                       |                                           2                              |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                        +                                 |   1        |
      Inflammation, Granulomatous          |                                        4                                 |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                         1                                   1            |      3  1.0|
      Inflammation, Chronic Active         |                                                                      3   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                2                                                         |      1  2.0|
      Cyst                                 |       2     1        3        2              4                           |      7  2.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Mineralization                       |                                              3                           |      1  3.0|
      Pigmentation                         |                                              3                           |      1  3.0|
      Thrombosis                           |                                              4                           |      1  4.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           | 3  3     2     2  2  4  4  2  2  2  3  2  4  4     4     2     3  3     2|     37  2.8|
      Endometrium, Hyperplasia, Cystic     | 2  2  2           1                 2  2     1           2  2            |     18  1.9|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                         2|      2  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |             4                                                            |      3  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                             +            |   4        |
      Inflammation, Granulomatous          |                                                             4            |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0|            |
                                           | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                   2                                               3      |      5  2.8|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    1  1  2  2  2  1  3  2  2        2  2  1  2  4        1  1  2  1  2  4|     39  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Cyst                                 |          1              1  1     1  1        2     2  2              2   |     16  1.5|
      Ectopic Parathyroid Gland            |                                              2                           |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Mononuclear Cell       |                                                    2                     |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Periosteum, Synovial Tissue,         |                                                                          |            |
          Inflammation, Chronic Active     |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                          +              +                  |   3        |
      Artery, Inflammation, Chronic Active |             2                                                            |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                         +                  |   2        |
      Sciatic, Inflammation, Chronic Active|             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |             +                                         +                  |   2        |
      Demyelination                        |             3                                         3                  |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                      1   |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                             2            |      3  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 3| 2| 6| 2| 2| 3| 3| 2| 3| 3| 2| 3| 2| 3| 0| 2| 0| 2| 2| 3| 2| 2| 0|            |
                                           | 8| 9| 0| 9| 7| 9| 8| 0| 0| 9| 0| 0| 9| 0| 9| 0| 5| 9| 1| 9| 8| 0| 9| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                         2                                                |      2  2.5|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                    +                              |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |    1     2                                         2                     |      6  1.8|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1     1  1  2  1  1     1  1  1  1  1     2     3  1  3     1  1|     40  1.2|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  1.0|
      Mineralization                       |                                              1                          1|      4  1.0|
      Nephropathy                          | 1        1     1           1                                   1     1   |     20  1.1|
      Cortex, Cyst                         |                                                                   2      |      1  2.0|
      Vein, Inflammation, Chronic Active   |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2  1  1  1  1  1     1  1  1                       1     1  2     1  1   |     25  1.1|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2|             
                                           | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         2|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                             X                     |             
      Clear Cell Focus                     |                                  X                                   X  X|             
      Eosinophilic Focus                   |                            X                          X     X     X  X   |             
      Fibrosis                             |                                                                          |             
      Infarct                              |    4                                                                     |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic Active         | 1     2                 1     1        1     1     1  1     1        1  1|             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                               X        X                             X  X|             
      Necrosis                             | 2     2                    1  1                 4  2  1                  |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                      1                                                  2|             
      Bile Duct, Hyperplasia               |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Fat, Necrosis                        |                                                             4            |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |       +  +  +                 +  +     +        +  +  +     +     +      |             
      Gingival, Foreign Body               |       X  X  X                 X  X     X        X  X  X     X     X      |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |       2  2  1                 2  1     1        1  2  1     1     2      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                        1                 1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1     1        1              1     1     1     1     1        1  1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2|             
                                           | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                       1                  |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |    1                 1                                         4         |             
      Epithelium, Hyperplasia              |    1                 2              2                          2         |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |    1                                                           2         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      |                   1     1  1     1              1  1                 1  2|             

                                            __________________________________________________________________________|             
   Tooth                                   |                                              +        +                  |             
      Malformation                         |                                              X        X                  |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1                                   1                              |             
      Atrium, Thrombosis                   |       4                                                                  |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   2                                                      |             
      Degeneration, Fatty                  |                                                                          |             
      Capsule, Hyperplasia                 | 2  1  1  2  3  1  1     1  1  1     1  2  2  1     1  1  2  4  1  1  1  2|             
      Zona Fasciculata, Hypertrophy        |          2     2                       2     1     1              1  1   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     2  2  2  2  1     2  2  2  2  2  2  1  3     2  3  2  1  2  2  2  2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  M  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                          1        1      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                       2           1      |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1                             1     1     1        1  1  1        1   |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2                                    |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |          2  2  1  1     2  2     1        2     1     2  2  2     1     2|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2|             
                                           | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                 1   |             
      Duct, Cyst                           |    3  2  2     2  2  2  2  2     2        2  4  2  2     2        2      |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1                                                  1  1  1        1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      2                                                   |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                            3                                             |             
      Bilateral, Dilatation                |                                                                         4|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphocyte              |                                                                          |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3     4     2              2        2           4     2  2     3  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  M  M  +|             
      Cyst                                 |             2     2                    2  1  2        1                  |             
      Hemorrhage                           |                                                                4         |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                4         |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Ulcer                                |       4                                                                  |             
      Epidermis, Hyperplasia               |       2                                                                  |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neuron, Necrosis                     |    2                                         1                           |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 6| 8| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 0| 2| 2| 2|             
                                           | 1| 7| 7| 8| 7| 9| 7| 3| 7| 8| 7| 7| 6| 8| 7| 2| 9| 8| 9| 8| 7| 1| 8| 7| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                            1                 1                           |             
      Alveolar Epithelium, Hyperplasia     |                            2                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   2        3        4                                    |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |       2                                                                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Atrophy                              | 4                                                                        |             

                                            __________________________________________________________________________|             
   Harderian Gland                         | +                 +  +                                         +         |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 2                                         2                       2     2|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1     1  1  1  1  1     1  1  1  1     1  1  2  1  1  1  1  1     1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                      2                                                   |             
      Metaplasia, Osseous                  |                                           1                              |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Necrosis                             |                      2                                                   |             
      Nephropathy                          | 2  1     2  1  1  1     2  1  1  1     1  1  2     1  1  2  1     2  2  1|             
      Pigmentation                         |                                                                          |             
      Cortex, Cyst                         |          2  2                                                        2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                           1  1                           |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|            |
                                           | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                     X                                    |      3     |
      Clear Cell Focus                     |                                                    X                     |      4     |
      Eosinophilic Focus                   |       X     X        X                          X  X  X                 X|     12     |
      Fibrosis                             |                         3                                                |      1  3.0|
      Infarct                              |                         4                                                |      2  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1           1                                             |      2  1.0|
      Inflammation, Chronic Active         |    1  1           1        1  1     1  1     1  1     2  1  1        1  1|     25  1.1|
      Mineralization                       |                         3                                                |      1  3.0|
      Mixed Cell Focus                     | X                                X                                       |      6     |
      Necrosis                             |          3              2     2                             1     2      |     12  1.9|
      Pigmentation                         |                         3  2                                             |      2  2.5|
      Vacuolization Cytoplasmic            |                         3                                                |      3  2.0|
      Bile Duct, Hyperplasia               |                            1                                             |      1  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |             +        +  +                                +  +  +         |   7        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                          1     1         |      2  1.0|
      Inflammation, Granulomatous          |             3                                               2            |      2  2.5|
      Mineralization                       |                                                                1         |      1  1.0|
      Fat, Necrosis                        |             4        4                                      4            |      4  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +  +     +     +  +     +        +  +  +  +  +     +  +  +  +         |  26        |
      Gingival, Foreign Body               |    X  X     X     X  X     X        X  X  X  X  X     X  X  X  X         |     26     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |    1  1     1     2  2                    1  1  1     3     2            |     21  1.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |             4                                                            |      1  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|            |
                                           | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy                      |             4                                                            |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                         2|      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1        1     1  1     1  1  1  1     1  1  1  1  1  1  1  1     1      |     27  1.0|
      Mineralization                       |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      3  2.0|
      Epithelium, Hyperplasia              | 3                                            2                           |      6  2.0|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      2  1.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Ectasia                      |             1           1                                1        2      |     12  1.2|

                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                               +              +      |   5        |
      Malformation                         |    X                                               X              X      |      5     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                               1                                          |      3  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                         1|      2  1.5|
      Degeneration, Fatty                  |                                                                         1|      1  1.0|
      Capsule, Hyperplasia                 | 2  1  3     1  1  1  1  1  1  1  3  2  2  1  1  1  2  1  1  2  1  1  1  2|     46  1.5|
      Zona Fasciculata, Hypertrophy        |    2  1     1                    2  2        1  1  1     1     1        2|     18  1.4|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  3  2  2  2  2  2  3  2  2  1  2  1  2  1  3  1     2  1  2  2  3|     46  1.9|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +|  36        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |                                                 2                        |      3  1.3|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                2                                      2                  |      4  1.8|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|            |
                                           | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                         3                                                |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1                 2     1     1     1     1  1  1  1  1     1         |     21  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  3              2        2     1  2  1  2  1     1     2           1  1|     27  1.6|
      Inflammation, Chronic Active         |             1        2        2                       3     3            |      7  2.1|
      Duct, Cyst                           |    2  2     2  2  2  2     2  2  3  2     2  2  3  3     2     2     3  3|     33  2.2|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1                 1     1     1     1              1  1  1        1   |     15  1.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |       3                    3                                             |      2  3.0|
      Inflammation, Chronic Active         |             2                                                            |      2  2.5|
      Bilateral, Dilatation                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |       3                                      2                           |      2  2.5|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphocyte              |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  2  3  2        1     2  4                 2     3  1  2        1   |     22  2.3|
      Hyperplasia, Lymphoid                |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  M  +  +|  37        |
      Cyst                                 | 1              1                                                     1   |      9  1.4|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |             3                                                            |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|            |
                                           | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |             4                                3              3            |      4  3.0|
      Ulcer                                |             4                                               4            |      3  4.0|
      Epidermis, Hyperplasia               |             3                                                            |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                   2                                                      |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Neuron, Necrosis                     |                                                                          |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |             2                                                            |      1  2.0|
      Inflammation, Chronic Active         |                   1                                                      |      1  1.0|
      Mineralization                       |                   1                                               1      |      4  1.0|
      Alveolar Epithelium, Hyperplasia     |                                        2                             4   |      3  2.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                      X                                                   |      2  2.0|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   5        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                            2  2  2              2        1     1     1   |     11  1.7|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1     1  1  2     2  1  1  1  1  1  1  2  1  1  1  1     1  1   |     42  1.1|
      Inflammation, Chronic Active         |             2                             1                              |      2  1.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 4| 2| 2| 2| 2| 1| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|            |
                                           | 7| 9| 9| 3| 7| 8| 8| 8| 7| 7| 5| 7| 8| 9| 8| 9| 8| 9| 7| 7| 7| 9| 1| 9| 8|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                      1                                                   |      2  1.0|
      Mineralization                       |    1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Nephropathy                          | 2  1  1  1  1  1  2  1     1  2  1  1  1  2  1  2  1  2  1  1  1  2  1  1|     44  1.3|
      Pigmentation                         |                                                                   3      |      1  3.0|
      Cortex, Cyst                         |                               3     2                                    |      5  2.2|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                1  1                                         1     1      |      6  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2|             
                                           | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |    4                                                                     |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                X                    X                                    |             
      Eosinophilic Focus                   |    X                 X           X     X           X     X              X|             
      Inflammation, Chronic Active         | 1  1                 1  2     1        1  1  1  1     1     1     1  1  1|             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                         2                                                |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +           +         |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                    4           4         |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             | +     +  +        +     +              +  +  +        +  +  +     +     +|             
      Gingival, Foreign Body               | X     X  X        X     X              X  X  X        X  X  X     X     X|             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           | 1     1  2        3     2                    1        1  1        2     1|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                               1           1                              |             
      Acinus, Atrophy                      |                         4                                                |             
      Artery, Inflammation, Chronic Active |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  1  1  1  2        1              1     1  1  2     1               |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                1         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Ectasia                      | 1     1           1  1  1     1                 1        1  1     1      |             

                                            __________________________________________________________________________|             
   Tooth                                   |                +                                         +           +  +|             
      Malformation                         |                X                                         X           X  X|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2|             
                                           | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Inflammation, Chronic Active  |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                         2                                                |             
      Capsule, Hyperplasia                 | 1        1  1  2  1  1  1  2  1  1  1  1  2  1  1  1     2  2  1  1  2  2|             
      Zona Fasciculata, Hyperplasia        |                                  2                                       |             
      Zona Fasciculata, Hypertrophy        | 1  2  1     1  1     1              1              2  2     1     1  2   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  2  2  3  3  2  2  3  1  2  2  2  2  1  2  3  1  2  3  2  2  2  2  3|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                    1                     |             
      Pars Distalis, Hyperplasia           |                                                                          |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicle, Cyst                       |                                                                1         |             
      Follicular Cell, Hyperplasia         |                            1                                             |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                               3                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1        2  1           1  1  1     1     1        1        1        1  1|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1  2        2     1     1  1  2           1  1     2  1  1     1  1  2|             
      Inflammation, Chronic Active         | 3           2                                            1           1   |             
      Duct, Cyst                           | 2  2              2  2  3     3  2     3     3  2     2  2  2     3  2  2|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |          1  1  1  1                 1     1  1     1     1  1     1      |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2|             
                                           | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                4                 3                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                         1|             
      Bilateral, Dilatation                |                            2                                             |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                                                     |             
      Renal, Hyperplasia, Lymphoid         |    4                                                                     |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |          3                                      2                        |             
      Infiltration Cellular, Eosinophil    |                                                 2                        |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2              2     2        3                                       |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  M  +  +|             
      Cyst                                 |                   2              2     2  1        1  1              1  1|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3                                                |             
      Ulcer                                |                         4                                                |             
      Epidermis, Hyperplasia               |                         3                                                |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |             3              1                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2|             
                                           | 9| 9| 9| 7| 7| 7| 9| 9| 8| 9| 8| 9| 7| 9| 7| 7| 8| 7| 7| 7| 9| 4| 8| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.075%                                 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Active                           |                                                                          |             
      Mediastinum, Pigmentation            |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   3                                                      |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +              +                 +|             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Chronic                |                                                       2                  |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |          1  2  1                                   1  2              3  2|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  2  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |          1                                         1                     |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1  1  1  1  2  1  1  2  1  2  1  1  1  2  1  2  1  1  1  1  1     1  2  2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Cortex, Cyst                         |       2                                      1                           |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1        1     1                                   1                  |             
      Inflammation, Suppurative            |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   2                          2                           |      2  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             3            |      2  3.5|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X                                X                              |      3     |
      Clear Cell Focus                     |       X  X                                X     X                        |      6     |
      Eosinophilic Focus                   |       X     X           X           X  X                 X        X      |     14     |
      Inflammation, Chronic Active         |          1     1                          1  1  1  1  1  1  1     1     1|     25  1.0|
      Mineralization                       |                                                                      1   |      1  1.0|
      Mixed Cell Focus                     |                                                 X                        |      2     |
      Necrosis                             | 2                                         2                    2     2   |      4  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +  +                 +     +               |   6        |
      Mineralization                       |                               3                                          |      1  3.0|
      Pigmentation                         |                               3                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                  2                                       |      1  2.0|
      Fat, Necrosis                        |                                                    4     4               |      4  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +  +        +  +  +  +        +     +  +     +  +     +  +  +            |  27        |
      Gingival, Foreign Body               | X  X        X  X  X  X        X     X  X     X  X     X  X  X            |     27     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           | 2           2  1  1           2     1  2     2  1     1  1  1            |     22  1.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      2  1.0|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                  3                                       |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1  1     1  1  1  1  1     1  1  1     1  1  1  1  1  1        1      |     28  1.1|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glands, Ectasia                      | 1        1        1  1           1                    1     1           1|     18  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                         +|   5        |
      Malformation                         |                                                                          |      4     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aorta, Inflammation, Chronic Active  |                                                       1                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                  2           2                           |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 |       2     1  1  1  2  3  1  2     1  1  1  2  2  1  1  1  1     2  1  1|     42  1.4|
      Zona Fasciculata, Hyperplasia        |                                                                          |      1  2.0|
      Zona Fasciculata, Hypertrophy        |    1  2  2     1     2  2              2  2  2     1  1           1      |     24  1.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2     2  2  2  2  2  1  2     1  2  2  1  2  2  2  2  1  3  2     2|     47  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |       1                                                                  |      2  1.0|
      Pars Distalis, Hyperplasia           |                   1                                                      |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                +         |   1        |
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cell                             |       1  1  1  1     1                 1  1     1        1              1|     22  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1  1  1     1  2              1  1  1  1     1     1     1     2|     28  1.3|
      Inflammation, Chronic Active         |                            2  2     2                    2               |      8  1.9|
      Duct, Cyst                           | 1  2  3  2  3                 3     3  2  2  2  2  2  3     2     2     2|     32  2.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1        1  1  1           1     2     1  1  1  1           2   |     22  1.1|
      Inflammation, Chronic Active         |             2                                                  2         |      2  2.0|
      Artery, Inflammation, Chronic Active |                                  2           3                           |      2  2.5|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      2  3.5|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Bilateral, Dilatation                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                3                                                         |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
      Infiltration Cellular, Eosinophil    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1                    2              2  1              1  2           2   |     11  1.8|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M|  39        |
      Cyst                                 | 1     2  1     2                 1        2                              |     14  1.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epidermis, Hyperplasia               |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                             1            |      1  1.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                              3                           |      1  3.0|
      Mediastinum, Pigmentation            |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                            2                                             |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   4        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                   2           2              2                           |     10  1.8|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1  1  1  1  2     2  1        1  1  1  2  1  1  1  1  1        1      |     41  1.1|
      Inflammation, Chronic Active         |                                                                2         |      1  2.0|
      Metaplasia, Osseous                  |                            1                                             |      3  1.0|
      Mineralization                       | 1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     50  1.0|
      Necrosis                             |                               2                                          |      1  2.0|
      Nephropathy                          | 1  1  1  1  1  2  1  1  1  3  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1|     49  1.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 0| 2|            |
                                           | 8| 8| 8| 8| 8| 8| 7| 9| 9| 2| 8| 4| 7| 7| 9| 7| 8| 7| 8| 7| 7| 7| 7| 1| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.075%                                 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Artery, Inflammation, Chronic Active |                                  2                    2                  |      2  2.0|
      Cortex, Cyst                         |             2                             2        2        1  2  2     2|      9  1.8|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                     1  1  1                              |      7  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|             
                                           | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Intussusception                      |                                                       X                  |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                            X        X        X     X                 X   |             
      Eosinophilic Focus                   |          X              X           X  X  X              X     X     X   |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1                                                                  |             
      Inflammation, Chronic Active         |    1     1  1  1  1     2  1  1        1  1           2  1     1  1  1   |             
      Mixed Cell Focus                     |                         X           X                                X  X|             
      Necrosis                             | 4     1     1                                      1  2                  |             
      Pigmentation                         |                                        1                                 |             
      Vacuolization Cytoplasmic            |                                              1                           |             
      Bile Duct, Hyperplasia               | 2                                                                        |             
      Hepatocyte, Karyomegaly              |                                                             1            |             

                                            __________________________________________________________________________|             
   Mesentery                               | +        +                    +        +                 +     +         |             
      Inflammation, Granulomatous          |                               3                                4         |             
      Pigmentation                         |                               4                                          |             
      Fat, Necrosis                        |          4                                               4               |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +     +  +  +  +  +     +                                             |             
      Gingival, Foreign Body               |    X     X  X  X  X  X     X                                             |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |    1     2  2  1     1     1                                             |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                      1   |             
      Acinus, Hypertrophy                  |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1        1  1     1        1  1  1     1  1        1  1  1     1   |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                       2                  |             
      Epithelium, Hyperplasia              |                                                       2                  |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                       2                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|             
                                           | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                       1                  |             
      Epithelium, Erosion                  |                                                    1                     |             
      Epithelium, Hyperplasia              |                                                                   2      |             
      Glands, Ectasia                      |                   1           1  2  1  1  1  1           1        1     1|             

                                            __________________________________________________________________________|             
   Tooth                                   |             +                             +                              |             
      Malformation                         |             X                             X                              |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             2        2                                      1            |             
      Degeneration, Fatty                  |                                                                         1|             
      Capsule, Hyperplasia                 | 1  1  1  1  1  1  1  1  2  1  1  1  1     1  2  1  1        1  2  1  2  3|             
      Zona Fasciculata, Hypertrophy        |    1     1                       1     2  1  1  1  1        1            |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1  2  2  3  2  2  2  3  1     2  2  2  3  1  2  1  2  3  2  2  2  2  3|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   1      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1        1           1     1  1  1  1  1  1  1     1     1  1  1      |             
      Inflammation, Chronic Active         |                1                                                         |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1           1  1        1     2  1  1  1  1           2     1     1   |             
      Inflammation, Chronic Active         |             2                                            2               |             
      Inflammation, Suppurative            |          2           3                                                   |             
      Duct, Cyst                           |    2  3     2  2           1  1     2  1     2  1     2  2     2  2  2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|             
                                           | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1        1  1  1           1  1  1        1        1        1  1     1   |             
      Inflammation, Chronic Active         |                                                             2     1      |             
      Inflammation, Suppurative            |                      3                                                   |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Suppurative            |                      4                                                   |             
      Bilateral, Dilatation                |                                                                         4|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Necrosis        |                                                       2                  |             
      Interstitial Cell, Hyperplasia       |                         2                                                |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                      4                                                   |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                      +                 +                                 |             
      Lumbar, Hyperplasia, Plasma Cell     |                      3                                                   |             
      Renal, Hyperplasia, Plasma Cell      |                      3                                                   |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Hyperplasia, Lymphocyte              |                4                                                         |             
      Inflammation, Granulomatous          |                4                                                         |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3           2  1     4        3        2           1  3                  |             
      Hyperplasia, Lymphoid                |                                                                   2      |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    1     1                 1  1  2                    1  1  1        1  2|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Ulcer                                |                      3                                                   |             
      Epidermis, Hyperplasia               |                      2                                                   |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Mononuclear Cell       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2|             
                                           | 3| 7| 7| 8| 8| 7| 8| 7| 9| 8| 8| 9| 8| 8| 7| 8| 7| 8| 7| 9| 8| 9| 9| 8| 8|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.15%                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                                                                     |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                             2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                         3|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                         2|             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   1                                                      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +  +        +                 +           +|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                2     4           2     2        2        2              3|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1     1  1  1  1        1  1  1  1  1  1  1  1        1  1  1  1  1  1|             
      Infiltration Cellular, Plasma Cell   |                      2                                                   |             
      Inflammation, Suppurative            |                      3                                                   |             
      Mineralization                       | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1|             
      Nephropathy                          |    1     1  1  1  1  3  1  2  1  2  1  2  1  1  1  1  3  1  1  2  1  1  2|             
      Artery, Inflammation, Chronic Active |             2                                                            |             
      Cortex, Cyst                         |                                              2                           |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |          1              1              1  1  1        1     1            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2|            |
                                           | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
      Intussusception                      |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                X         |      1     |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |    X                             X     X           X              X      |     10     |
      Eosinophilic Focus                   |          X           X  X              X  X                 X            |     14     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1              1                                                         |      3  1.0|
      Inflammation, Chronic Active         | 1  1  1     1        1  1           1  1  1  1  1  1     1        1  1  1|     31  1.1|
      Mixed Cell Focus                     |                                        X  X        X                     |      7     |
      Necrosis                             |                                                       2                  |      6  1.8|
      Pigmentation                         |                                                                      2   |      2  1.5|
      Vacuolization Cytoplasmic            |    2                                               2                     |      3  1.7|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                             +            |   7        |
      Inflammation, Granulomatous          |                                                                          |      2  3.5|
      Pigmentation                         |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                             4            |      3  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |             +  +        +  +     +        +  +     +     +           +   |  17        |
      Gingival, Foreign Body               |             X  X        X  X     X        X  X     X     X           X   |     17     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |             1  1        2                 1  2     1     1           2   |     14  1.4|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |       1                                                     1            |      3  1.0|
      Acinus, Hypertrophy                  |                                                                      1   |      1  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1     1  1  1  1     1           1  1  1  1  1  1  1  1  1  1  1  1  1  1|     33  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2|            |
                                           | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                 2                        |      2  2.0|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                 1                        |      2  1.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Epithelium, Erosion                  |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                              1                           |      2  1.5|
      Glands, Ectasia                      |    1                             1  1  1     1                    1      |     16  1.1|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                        +                          +      |   4        |
      Malformation                         |                                                                   X      |      3     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                1         |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       1                 2  2                                             |      6  1.7|
      Degeneration, Fatty                  |                                                                          |      1  1.0|
      Capsule, Hyperplasia                 |    1  1  2  1  1  1  1  1     1     2  1  1  1  1  2              1  1  1|     40  1.2|
      Zona Fasciculata, Hypertrophy        |                         1        3     1                    2        1   |     14  1.3|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  2  2  1  2  2  1  2  1  3  2  2  1  2  1  2  2  2  2  3  2  2  2|     49  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  M  +  +  +  M  +  +|  38        |
      Cyst                                 |                                           2                              |      1  2.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  | 2                                                                        |      2  1.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                                              2                           |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2|            |
                                           | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1     1     1     1           1     1  1           1     1        1   |     25  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Atrophy                              |                                                                3         |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1  1  2  1  1  1     1  1     1        1  2     2        1     1|     29  1.2|
      Inflammation, Chronic Active         | 2                                                        2               |      4  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Duct, Cyst                           | 2  2  2     2  2     2  2  3  2  2  2  2  3  3  2        2        2     2|     33  2.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1     1  1  1  1  1     1        1  1     1  1  1  1  1  1  1        1   |     29  1.0|
      Inflammation, Chronic Active         |                            3                                             |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |       1                                                                  |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Bilateral, Dilatation                |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Necrosis        |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                      4                                                   |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                             2            |      1  2.0|
      Thrombosis                           |                                                             2            |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   3        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |          4                                                               |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Plasma Cell             |          3                                                               |      1  3.0|
      Hyperplasia, Lymphocyte              |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2|            |
                                           | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |          1  2                       2              1  3              2   |     14  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  M  M  M  M  M  +  +  +  +  M  +  +  +  +|  38        |
      Cyst                                 |       1        2                                1  2     2        2      |     16  1.4|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +|   1        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Mononuclear Cell       |                   1                                                      |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |          1              1                                         1      |      3  1.0|
      Alveolar Epithelium, Hyperplasia     |                               1  3  1           1           1            |      6  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 3                        |      2  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |             2                                                        1   |      3  1.5|
      Inflammation, Chronic Active         |             2                                                        1   |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   6        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 6| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2|            |
                                           | 8| 8| 7| 9| 7| 7| 4| 7| 7| 3| 8| 9| 7| 8| 7| 8| 8| 7| 6| 8| 7| 1| 7| 8| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    0.15%                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                            2                                             |      1  2.0|
      Infarct                              |                                        2        1                        |      9  2.2|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1  1  1     1  1     1  1  1  1  1  1  1  1  1  1  1        1  1|     41  1.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     48  1.0|
      Nephropathy                          | 1  1  1  1  1  1     1  1  2  2  1  1  1  1  1  1  1     1  1     1  1  1|     45  1.2|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Cortex, Cyst                         |          2     2                 3           1                          1|      6  1.8|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1           1        1           1  1                 1     1     1     1|     16  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
                                           | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Inflammation,         |                                                                          |             
          Granulomatous                    |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    X                                               X  X  X               |             
      Eosinophilic Focus                   |          X     X                          X           X        X         |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic Active         |       1        2  2        1                 1        1  1  1  1  1      |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |          X                 X                                             |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       2                  |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |          +  +           +        +     +                                 |             
      Fat, Necrosis                        |          4                             4                                 |             

                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +  +              +  +  +              +     +        +     +  +      |             
      Gingival, Foreign Body               |    X  X              X  X  X              X     X        X     X  X      |             
      Gingival, Inflammation, Chronic      |                                                                          |             
          Active                           |                      1                          1        1     2  2      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1  1        1        1  1        1  1  1  1  1  1     1     1     1|             
      Mineralization                       |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |             4                                                            |             
      Epithelium, Hyperplasia              |             1                                                  2         |             
      Epithelium, Inflammation, Chronic    |                                                                          |             
          Active                           |             1                                                            |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
                                           | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              | 2                 3                    2  2                 1  2         |             
      Epithelium, Necrosis                 |                                                                          |             
      Glands, Ectasia                      |                                     1  2  2        1     1  1     1  1   |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          2        2                                                      |             
      Capsule, Hyperplasia                 |    1  2  1  1  1  1  1  1  1  1  1  1  2  1  1     1  1  1  1  1  1  2  1|             
      Zona Fasciculata, Hyperplasia        |                            2                                             |             
      Zona Fasciculata, Hypertrophy        |    1  1        1                    1  1  1        1     1  1     2  1  1|             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1  2  3  3     2  2     2  3  2  2  1  2  2  2  2  2  2     1  2  2  2|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |          2                                                               |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                2                                                         |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                          2               |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1     1     1     1     1  1        1              1     1            |             
      Infiltration Cellular, Mixed Cell    |                                  2                                       |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       2           1  1     1           1  1     1  2  2  1  1  1         |             
      Inflammation, Chronic Active         |          2           1                                                   |             
      Duct, Cyst                           |    2     2  2  2  3  2  3  2  2  2  3  2  2  2  2     2  2  2        2  2|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                   1  1     1  1        1  1  1  1  1        1  1  1  1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
                                           | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                   1      |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                          2               |             
      Germinal Epithelium, Atrophy         |                                                          2               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                  3                                       |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                         +        +                                       |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Inflammation, Granulomatous          |                3                                                         |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1           4  2           3     2           1        1     1           2|             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               1        2              2              1   |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             4                                                            |             
      Necrosis                             |             4                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                 1  2  1                 1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                    2                     |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6|             
                                           | 7| 8| 7| 9| 9| 8| 7| 8| 4| 8| 7| 4| 8| 7| 8| 8| 7| 9| 8| 8| 7| 7| 8| 8| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.30%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              | 2  2  2     4     2                       1        2  2           1  2   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             | 1  1  1  1     1  1  1     2  1     1  1  1  1  1     1  1  1  1  1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |             
      Nephropathy                          | 1  1  1  1     1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Cortex, Cyst                         |                                                    1                     |             
      Renal Tubule, Hypertrophy, Focal     |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |             1                                   1                 1  1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                     2     2                              |      2  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peyer's Patch, Inflammation,         |                                                                          |            |
          Granulomatous                    |                                        4                                 |      1  4.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X                                                                        |      1     |
      Clear Cell Focus                     |                   X                                X  X                  |      7     |
      Eosinophilic Focus                   |                   X           X                                          |      7     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                          1               |      1  1.0|
      Inflammation, Chronic Active         | 1     1  1           1           1     1              3     1        1   |     19  1.2|
      Mineralization                       |                   1                          1                           |      2  1.0|
      Mixed Cell Focus                     |       X           X        X  X        X  X           X                  |      9     |
      Necrosis                             |                                     3        4                           |      2  3.5|
      Pigmentation                         |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                         2                                                |      1  2.0|
      Bile Duct, Hyperplasia               |                                                       2  1               |      2  1.5|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Necrosis                        |                                                                          |      2  4.0|

                                            __________________________________________________________________________|____________|
   Oral Mucosa                             | +     +  +  +        +  +                             +  +  +            |  19        |
      Gingival, Foreign Body               | X     X  X  X        X  X                             X  X  X            |     19     |
      Gingival, Inflammation, Chronic      |                                                                          |            |
          Active                           |       3  2           1  2                             2     1            |     11  1.6|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1        1                                                               |      2  1.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1  1  1  1  1  1              1  1  1  1     1  1     1  1     1  1   |     32  1.0|
      Mineralization                       |                1                                                         |      1  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                     1                                    |      3  1.3|
      Epithelium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                           2        2              2  2   |     10  2.0|
      Epithelium, Necrosis                 |                                     2                                    |      1  2.0|
      Glands, Ectasia                      |                                  1        2              1  1     1  1   |     14  1.2|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +                                             |   1        |
      Malformation                         |                            X                                             |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                     1                                    |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                         2              2                                 |      4  2.0|
      Capsule, Hyperplasia                 | 1     1  1  1     1  1     1  1     1     1  1     1     1  1     2  1  1|     40  1.1|
      Zona Fasciculata, Hyperplasia        |                                                                          |      1  2.0|
      Zona Fasciculata, Hypertrophy        |          1        1     1        1        2           1  1        1  1   |     21  1.1|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2  2  3     2  2  2  2  3  2  2  2     2  2  2  2  1  2  1     2  2  1|     44  2.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +|  41        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |       1                 2  1                                             |      4  1.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Cyst                       |                               2                                          |      2  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cell                             |       1  1     1  1  1        1  1  1     1     1  1     1  1  1     1   |     25  1.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |       1           1  1  1  1     1     1        1     1  2        1  1  2|     25  1.2|
      Inflammation, Chronic Active         |          3              2                                                |      4  2.0|
      Duct, Cyst                           |       2  2     4  2  2  2     2  3  3  2  3  3  3     3  3  2     2  2  2|     39  2.3|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1        1     1  1  1  1     1     1  1  1        1  1  1  1        1   |     28  1.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            4                                             |      1  4.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                         1                                                |      2  1.5|
      Germinal Epithelium, Atrophy         |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |    4                                                                     |      2  3.5|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                   +     +                           |   5        |
      Mediastinal, Hemorrhage              |                                              4                           |      1  4.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                        4                                 |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                        4                                 |      2  3.5|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |    2  3     2  3  1           1     4        4  1     2                 3|     20  2.2|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|  42        |
      Cyst                                 | 2     1                                   2                          2  2|      9  1.7|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       4                                                                 4|      2  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 88007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           SODIUM NITRITE                                      Date: 05/13/99  
Route: DOSED WATER                                                                                                Time: 09:43:12  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 2| 2| 8| 8| 2| 2| 2| 5| 2| 2| 4| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 2| 2|            |
                                           | 8| 2| 7| 9| 5| 3| 9| 8| 7| 6| 7| 8| 9| 7| 9| 8| 8| 7| 7| 8| 9| 2| 7| 7| 7|      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    0.30%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |       4                                                                 4|      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |    4                                                                     |      2  4.0|
      Alveolar Epithelium, Hyperplasia     |          4                 1  2  2                             1         |      9  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                           3                       2      |      3  2.3|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |          2                                                               |      1  2.0|
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                            2                                             |      1  2.0|
      Infarct                              |                         2                       2           2            |     13  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1|     45  1.0|
      Inflammation, Chronic Active         |                                     1                                    |      1  1.0|
      Mineralization                       | 1  1     1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1     1  1  1|     46  1.0|
      Nephropathy                          | 1  1  1  1        1  1  1  1  1  1     1        1  1  1  1  1     1  1  1|     42  1.0|
      Cortex, Cyst                         |                         2                       2                 1      |      4  1.5|
      Renal Tubule, Hypertrophy, Focal     |                               2                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          1        1                                   1  1  1           1|     10  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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