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https://ntp.niehs.nih.gov/go/14471

TDMS Study 88031-05 Pathology Tables

NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02
Route: DOSED WATER                                                                                                Time: 10:20:44

                                                            FINAL#3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  25265-71-8

       Lock Date:  11/09/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9           10            6            6                                     
    Moribund Sacrifice                                11            9            6           12                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           37           31                                     
    Natural Death                                                                1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (47)         (48)         (46)                                   
      Parasite Metazoan                                4 (8%)       4 (9%)       1 (2%)       2 (4%)                                
   Intestine Large, Rectum                            (48)         (47)         (49)         (46)                                   
      Parasite Metazoan                                7 (15%)      5 (11%)     13 (27%)      3 (7%)                                
   Intestine Small, Ileum                             (44)         (41)         (47)         (45)                                   
      Necrosis                                                                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (49)                                   
      Angiectasis                                                   2 (4%)                                                          
      Basophilic Focus                                46 (92%)     46 (92%)     49 (98%)     46 (94%)                               
      Clear Cell Focus                                10 (20%)     16 (32%)     20 (40%)     17 (35%)                               
      Eosinophilic Focus                                                         1 (2%)       4 (8%)                                
      Fatty Change                                     6 (12%)      9 (18%)      6 (12%)      4 (8%)                                
      Hepatodiaphragmatic Nodule                       4 (8%)       7 (14%)      6 (12%)      6 (12%)                               
      Inflammation, Focal, Granulomatous              30 (60%)     33 (66%)     37 (74%)     26 (53%)                               
      Inflammation, Focal, Histiocytic                39 (78%)     37 (74%)     36 (72%)     28 (57%)                               
      Mixed Cell Focus                                 1 (2%)       7 (14%)      7 (14%)      4 (8%)                                
      Necrosis                                                      1 (2%)                                                          
      Tension Lipidosis                                             1 (2%)                                                          
      Bile Duct, Hyperplasia                           2 (4%)       3 (6%)       7 (14%)     18 (37%)                               
      Centrilobular, Necrosis                          6 (12%)      8 (16%)      2 (4%)       6 (12%)                               
   Mesentery                                          (15)         (13)         (13)         (11)                                   
      Fat, Hemorrhage                                               1 (8%)                                                          
      Fat, Necrosis                                   14 (93%)     13 (100%)    11 (85%)      8 (73%)                               
   Pancreas                                           (47)         (48)         (48)         (48)                                   
      Atrophy                                          7 (15%)     10 (21%)      6 (13%)     10 (21%)                               
      Basophilic Focus                                 3 (6%)       2 (4%)       3 (6%)       3 (6%)                                
      Hyperplasia                                      2 (4%)       1 (2%)       4 (8%)       3 (6%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                          3 (6%)       4 (8%)       3 (6%)       1 (2%)                                
      Basophilic Focus                                 1 (2%)       3 (6%)       5 (10%)                                            
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (50)         (48)                                   
      Foreign Body                                     1 (2%)                                                                       
      Hyperplasia, Squamous                            4 (8%)       3 (6%)       3 (6%)       2 (4%)                                
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                            2 (4%)       6 (12%)      2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (49)         (47)         (49)         (47)                                   
      Hypertrophy, Focal                                            1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                         3 (6%)       2 (4%)       2 (4%)       4 (9%)                                
      Neuroendocrine Cell, Hyperplasia                              1 (2%)                                                          
   Tooth                                              (6)          (2)          (1)          (1)                                    
      Inflammation, Chronic Active                     6 (100%)     2 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  33 (66%)     42 (84%)     32 (64%)     26 (52%)                               
      Atrium, Thrombosis                                            2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (47)         (47)         (47)                                   
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Atrophy                                                       1 (2%)                                                          
      Degeneration, Cystic                             5 (10%)      2 (4%)                                                          
      Hyperplasia                                     18 (37%)     24 (51%)     25 (53%)     13 (28%)                               
      Hypertrophy                                     11 (22%)     14 (30%)     12 (26%)      9 (19%)                               
      Necrosis                                         1 (2%)       2 (4%)                    2 (4%)                                
      Thrombosis                                       1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (47)         (46)         (47)                                   
      Hyperplasia                                     12 (24%)      8 (17%)     10 (22%)      7 (15%)                               
      Necrosis                                                                                2 (4%)                                
   Parathyroid Gland                                  (49)         (47)         (47)         (49)                                   
      Hyperplasia                                                                             2 (4%)                                
   Pituitary Gland                                    (48)         (45)         (50)         (47)                                   
      Angiectasis                                                                3 (6%)       2 (4%)                                
      Cyst                                                          1 (2%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      19 (40%)     15 (33%)     22 (44%)     19 (40%)                               
   Thyroid Gland                                      (45)         (45)         (46)         (46)                                   
      C-Cell, Hyperplasia                             36 (80%)     36 (80%)     38 (83%)     28 (61%)                               
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (44)         (48)         (48)                                   
      Hyperplasia                                      5 (10%)      2 (5%)       3 (6%)       3 (6%)                                
      Inflammation, Chronic Active                     2 (4%)                                 1 (2%)                                
   Ovary                                              (50)         (50)         (49)         (48)                                   
      Cyst                                             4 (8%)       6 (12%)      7 (14%)      8 (17%)                               
      Inflammation, Granulomatous                                                             1 (2%)                                
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
   Uterus                                             (50)         (48)         (50)         (49)                                   
      Hydrometra                                       1 (2%)                                                                       
      Hyperplasia, Cystic                              1 (2%)                    1 (2%)       1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (15)         (11)         (8)          (14)                                   
      Deep Cervical, Ectasia                                                     2 (25%)                                            
      Deep Cervical, Hyperplasia                                                              1 (7%)                                
      Iliac, Inflammation, Suppurative                 1 (7%)                                                                       
      Mediastinal, Ectasia                                          1 (9%)                    1 (7%)                                
      Mediastinal, Hemorrhage                          1 (7%)                                                                       
      Mediastinal, Hyperplasia                         1 (7%)                                                                       
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      1 (9%)                    1 (7%)                                
      Pancreatic, Inflammation, Granulomatous          1 (7%)                                                                       
   Lymph Node, Mesenteric                             (49)         (47)         (49)         (48)                                   
      Ectasia                                                       1 (2%)                                                          
   Spleen                                             (48)         (48)         (49)         (48)                                   
      Accessory Spleen                                                           1 (2%)                                             
      Hematopoietic Cell Proliferation                 7 (15%)      7 (15%)      4 (8%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)       3 (6%)                                
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (49)                                   
      Galactocele                                      3 (6%)       3 (6%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                                            2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Osteopetrosis                                    1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (1)          (1)                                                              
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Meninges, Fibrosis                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Cyst, Squamous                                                             1 (2%)                                             
      Infiltration Cellular, Histiocyte               46 (92%)     47 (94%)     46 (92%)     45 (92%)                               
      Inflammation, Chronic Active                     8 (16%)      4 (8%)       8 (16%)     11 (22%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          
      Metaplasia, Squamous                                                       1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                11 (22%)     15 (30%)     17 (34%)      8 (16%)                               
      Bronchiole, Hyperplasia                          1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (48)         (48)         (46)         (49)                                   
      Inflammation, Suppurative                       10 (21%)      5 (10%)      7 (15%)      4 (8%)                                
      Thrombosis                                       1 (2%)       4 (8%)                    3 (6%)                                
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Olfactory Epithelium, Degeneration                                                      9 (18%)                               
      Olfactory Epithelium, Metaplasia                                           1 (2%)       1 (2%)                                
      Olfactory Epithelium, Metaplasia, Squamous                                 1 (2%)                                             
      Respiratory Epithelium, Accumulation,                                                                                         
          Hyaline Droplet                             40 (83%)     36 (75%)     37 (80%)     46 (94%)                               
      Respiratory Epithelium, Hyperplasia                                        1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)          (3)                                    
      Cataract                                         2 (100%)                  2 (100%)     1 (33%)                               
      Degeneration                                                                            2 (67%)                               
      Inflammation, Chronic Active                                  1 (100%)                                                        
      Cornea, Inflammation, Suppurative                1 (50%)                                                                      
      Retina, Atrophy                                  2 (100%)                  1 (50%)      2 (67%)                               
   Harderian Gland                                    (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (49)         (47)                                   
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          3 (6%)       2 (4%)       1 (2%)       4 (9%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Nephropathy                                     43 (88%)     45 (92%)     47 (96%)     46 (98%)                               
      Pelvis, Inflammation, Acute                                   1 (2%)       1 (2%)                                             
      Renal Tubule, Hypertrophy                        1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)       1 (2%)                                
   Ureter                                             (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Urinary Bladder                                    (50)         (48)         (48)         (46)                                   
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12           14           18           31                                     
    Natural Death                                     15            9            5           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           27           27                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (41)         (49)         (48)         (43)                                   
      Parasite Metazoan                                4 (10%)      1 (2%)       3 (6%)                                             
      Ulcer                                                         1 (2%)                    1 (2%)                                
   Intestine Large, Rectum                            (40)         (50)         (48)         (44)                                   
      Parasite Metazoan                                6 (15%)      3 (6%)       6 (13%)                                            
   Intestine Large, Cecum                             (38)         (46)         (47)         (35)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (39)         (49)         (49)         (42)                                   
      Necrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (37)         (42)         (47)         (36)                                   
      Necrosis                                                                                1 (3%)                                
   Liver                                              (50)         (50)         (49)         (48)                                   
      Angiectasis                                                                             2 (4%)                                
      Basophilic Focus                                24 (48%)     35 (70%)     26 (53%)     45 (94%)                               
      Clear Cell Focus                                22 (44%)     22 (44%)     23 (47%)      2 (4%)                                
      Degeneration, Cystic                             4 (8%)       3 (6%)       6 (12%)      2 (4%)                                
      Eosinophilic Focus                               1 (2%)                    2 (4%)                                             
      Fatty Change                                     6 (12%)      5 (10%)      3 (6%)       5 (10%)                               
      Hepatodiaphragmatic Nodule                       3 (6%)       5 (10%)      4 (8%)       5 (10%)                               
      Inflammation, Focal, Granulomatous              22 (44%)     26 (52%)     42 (86%)     27 (56%)                               
      Inflammation, Focal, Histiocytic                18 (36%)     27 (54%)     46 (94%)     48 (100%)                              
      Mixed Cell Focus                                              2 (4%)       2 (4%)       2 (4%)                                
      Regeneration                                     3 (6%)                                                                       
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia                          34 (68%)     38 (76%)     43 (88%)     44 (92%)                               
      Centrilobular, Necrosis                         15 (30%)     11 (22%)     12 (24%)      3 (6%)                                
   Mesentery                                          (14)         (11)         (6)          (4)                                    
      Fat, Inflammation                                1 (7%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                   12 (86%)      9 (82%)      5 (83%)      4 (100%)                              
   Oral Mucosa                                        (1)                                    (2)                                    
      Pharyngeal, Hyperplasia                                                                 1 (50%)                               
      Pharyngeal, Necrosis                             1 (100%)                                                                     
   Pancreas                                           (44)         (49)         (50)         (47)                                   
      Atrophy                                         17 (39%)     20 (41%)     12 (24%)      9 (19%)                               
      Basophilic Focus                                 1 (2%)       2 (4%)       2 (4%)                                             
      Hyperplasia                                      7 (16%)      6 (12%)      4 (8%)       5 (11%)                               
      Thrombosis                                                    1 (2%)                                                          
      Artery, Inflammation                             1 (2%)                                                                       
   Salivary Glands                                    (49)         (49)         (50)         (50)                                   
      Atrophy                                          1 (2%)       5 (10%)                                                         
      Basophilic Focus                                 1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                   22 (44%)                               
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia, Basal Cell                                                    1 (2%)       2 (4%)                                
      Hyperplasia, Diffuse, Squamous                   2 (4%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Squamous                                         1 (2%)       3 (6%)       5 (10%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Ulcer                                            3 (6%)       5 (10%)      8 (16%)     10 (20%)                               
   Stomach, Glandular                                 (46)         (49)         (50)         (48)                                   
      Cyst, Squamous                                                                          1 (2%)                                
      Metaplasia                                                    1 (2%)                                                          
      Mineralization                                                1 (2%)                    2 (4%)                                
      Necrosis                                         5 (11%)      7 (14%)      2 (4%)       5 (10%)                               
   Tooth                                              (1)                       (3)                                                 
      Inflammation, Chronic Active                     1 (100%)                  3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)                       (2)                                    
      Inflammation, Granulomatous                      1 (100%)                                                                     
      Aorta, Mineralization                                                                   1 (50%)                               
   Heart                                              (50)         (50)         (50)         (49)                                   
      Cardiomyopathy                                  41 (82%)     42 (84%)     43 (86%)     22 (45%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Mineralization                                                                          7 (14%)                               
      Necrosis                                                                   1 (2%)                                             
      Atrium, Thrombosis                                            5 (10%)      2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Valve, Inflammation, Acute                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (47)         (49)         (50)         (48)                                   
      Degeneration, Cystic                             1 (2%)                                                                       
      Hyperplasia                                     15 (32%)     22 (45%)     26 (52%)      8 (17%)                               
      Hypertrophy                                      5 (11%)      4 (8%)       6 (12%)      5 (10%)                               
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Necrosis                                         1 (2%)       4 (8%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Adrenal Medulla                                    (47)         (49)         (50)         (47)                                   
      Hyperplasia                                     23 (49%)     23 (47%)     24 (48%)      4 (9%)                                
      Necrosis                                         1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (44)         (48)         (50)         (47)                                   
      Hyperplasia                                                                2 (4%)                                             
   Parathyroid Gland                                  (45)         (48)         (49)         (50)                                   
      Hyperplasia                                                   4 (8%)       1 (2%)       5 (10%)                               
   Pituitary Gland                                    (47)         (49)         (50)         (49)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Cyst                                                          4 (8%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                       9 (19%)     16 (33%)     16 (32%)      6 (12%)                               
   Thyroid Gland                                      (42)         (47)         (48)         (47)                                   
      C-Cell, Hyperplasia                             24 (57%)     26 (55%)     31 (65%)      3 (6%)                                
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
      Granuloma Sperm                                                                         1 (2%)                                
   Preputial Gland                                    (50)         (47)         (50)         (50)                                   
      Cyst                                                                                    2 (4%)                                
      Hyperplasia                                      1 (2%)       3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
   Prostate                                           (48)         (50)         (50)         (50)                                   
      Hyperplasia                                     11 (23%)     11 (22%)     10 (20%)      5 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     8 (17%)      8 (16%)     12 (24%)                                            
   Seminal Vesicle                                    (43)         (48)         (49)         (46)                                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       4 (8%)       1 (2%)       3 (6%)                                
      Interstitial Cell, Hyperplasia                   3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (48)         (50)         (48)                                   
      Inflammation, Granulomatous                                                1 (2%)                                             
   Lymph Node                                         (18)         (14)         (21)         (9)                                    
      Bronchial, Ectasia                                                         1 (5%)                                             
      Mediastinal, Ectasia                             2 (11%)                   1 (5%)       2 (22%)                               
      Mediastinal, Hemorrhage                                                                 1 (11%)                               
      Mediastinal, Hyperplasia                                                   1 (5%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                                   1 (5%)                                             
      Mediastinal, Inflammation, Granulomatous                                                1 (11%)                               
   Lymph Node, Mesenteric                             (44)         (48)         (49)         (47)                                   
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Spleen                                             (43)         (50)         (49)         (47)                                   
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                         6 (14%)      5 (10%)      4 (8%)       2 (4%)                                
      Hematopoietic Cell Proliferation                 2 (5%)       5 (10%)      2 (4%)                                             
      Hemorrhage                                       2 (5%)                                                                       
      Hyperplasia, Focal, Lymphoid                     4 (9%)       4 (8%)       9 (18%)      2 (4%)                                
      Necrosis                                                      3 (6%)       2 (4%)                                             
   Thymus                                             (39)         (48)         (43)         (41)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Hemorrhage                                       1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (41)         (47)         (44)                                   
      Galactocele                                      1 (2%)                    1 (2%)                                             
   Skin                                               (48)         (48)         (49)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Foreign Body                                                  1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)       4 (8%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Prepuce, Inflammation, Suppurative                            1 (2%)                                                          
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)          (2)                                    
      Cyst, Squamous                                                             1 (100%)                                           
      Mineralization                                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Gliosis                                                                    1 (2%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (49)                                   
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte               32 (64%)     35 (71%)     39 (78%)     34 (69%)                               
      Inflammation, Chronic Active                     3 (6%)       2 (4%)       4 (8%)       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)       1 (2%)       3 (6%)                                             
      Mineralization                                                1 (2%)                    1 (2%)                                
      Thrombosis                                                    2 (4%)       1 (2%)       3 (6%)                                
      Alveolar Epithelium, Hyperplasia                11 (22%)     18 (37%)     10 (20%)      5 (10%)                               
      Mediastinum, Necrosis, Fatty                     1 (2%)                                                                       
   Nose                                               (46)         (50)         (50)         (49)                                   
      Foreign Body                                                  2 (4%)                                                          
      Inflammation, Suppurative                       11 (24%)     17 (34%)     15 (30%)      6 (12%)                               
      Thrombosis                                       2 (4%)       5 (10%)      4 (8%)       9 (18%)                               
      Goblet Cell, Respiratory Epithelium,                                                                                          
          Hyperplasia                                               1 (2%)                                                          
      Olfactory Epithelium, Atrophy                    4 (9%)       3 (6%)       3 (6%)      34 (69%)                               
      Olfactory Epithelium, Degeneration                                                      7 (14%)                               
      Olfactory Epithelium, Metaplasia                 4 (9%)       1 (2%)                    2 (4%)                                
      Respiratory Epithelium, Hyperplasia                                                     1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:20:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.25%        1.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Pleura                                                                       (2)                                                 
      Inflammation, Chronic                                                      1 (50%)                                            
      Inflammation, Suppurative                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (3)          (1)                                    
      Cataract                                         2 (100%)     1 (50%)      2 (67%)      1 (100%)                              
      Degeneration                                                               1 (33%)                                            
      Cornea, Inflammation, Suppurative                             1 (50%)                                                         
      Cornea, Mineralization                                        1 (50%)                                                         
      Retina, Atrophy                                  1 (50%)      1 (50%)      2 (67%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (47)         (50)         (50)         (48)                                   
      Cyst                                                                       3 (6%)                                             
      Hydronephrosis                                                1 (2%)                    1 (2%)                                
      Infarct                                          3 (6%)       6 (12%)      3 (6%)       2 (4%)                                
      Metaplasia, Osseous                                           1 (2%)                                                          
      Mineralization                                                2 (4%)       1 (2%)       2 (4%)                                
      Nephropathy                                     41 (87%)     47 (94%)     50 (100%)    48 (100%)                              
      Pigmentation                                     1 (2%)       2 (4%)       1 (2%)                                             
      Papilla, Necrosis                                             1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet                                2 (4%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)       3 (6%)       7 (14%)      9 (19%)                               
   Urinary Bladder                                    (46)         (50)         (49)         (49)                                   
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                                                1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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