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TDMS Study 88031-05 Pathology Tables

NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02
Route: DOSED WATER                                                                                                Time: 10:30:16

                                                            FINAL#3




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  25265-71-8

       Lock Date:  11/09/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|             
                                           | 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                      X                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                X                    X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X     X|             
      Clear Cell Focus                     |                X  X                 X              X                    X|             
      Fatty Change                         |             2              3                                         2   |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Focal, Granulomatous   |    1  1        1  1     1     1  1  2  1  1  1     1  1  2     2        1|             
      Inflammation, Focal, Histiocytic     | 1  1  1     1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1        1|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |       2                                                                 1|             
      Centrilobular, Necrosis              |             1        1     3                                         1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +  +     +  +  +  +        +                    +  +         |             
      Fat, Necrosis                        |             2  2        2  2  2        2                    2  3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1        2                                2                 1         |             
      Basophilic Focus                     |                                  X           X                           |             
      Hyperplasia                          |    1                                                                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                               2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|             
                                           | 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Basophilic Focus                     |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         X                                                |             
      Hyperplasia, Squamous                |                            2           1  2                              |             
      Inflammation, Granulomatous          |                         1                                                |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      1   |             
      Necrosis                             |                            2                                         3   |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +     +                                   +                        |             
      Inflammation, Chronic Active         | 2     3     2                                   3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1     1  1  1  1        2  2     1  1     2     1  1  2  1           2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                              2           2               |             
      Hyperplasia                          | 2  1           1                 2     2           2  2     1  2         |             
      Hypertrophy                          | 2        3                    3  1                                       |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |             2                                                            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                 1        1  2  1                                 |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|             
                                           | 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |       4        3  2                 1  2           2  4  3        2     2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  2  2     1  1     2        3  2  2  1  1        1  2  3  1  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          4              2|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Thrombosis                           |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +           +        +     +  +           +                    +   |             
      Iliac, Inflammation, Suppurative     |                                                 4                        |             
      Mediastinal, Hemorrhage              |                            2                                             |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  M  +  +  M  M  M  M  +  M  M  M  M  M  +  M  M  +  M  M  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|             
                                           | 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      4                       3  4                        |             
      Hemorrhage                           |                                  2                                       |             
      Necrosis                             |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    2                          4                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Osteopetrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1|             
      Inflammation, Chronic Active         | 1                                      1                                1|             
      Thrombosis                           |                                                 2                        |             
      Alveolar Epithelium, Hyperplasia     |                                        1  1           1                 2|             
      Bronchiole, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 4| 7| 2| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 3| 2| 3| 4| 9| 2| 5| 3| 3| 3| 1| 3| 4| 3| 9| 3| 2| 3| 2| 9| 3|             
                                           | 9| 0| 1| 9| 1| 9| 1| 0| 7| 4| 9| 1| 1| 1| 3| 0| 7| 0| 7| 1| 9| 1| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation, Suppurative            |                   1        1              1        2                     |             
      Thrombosis                           |                                                                          |             
      Respiratory Epithelium, Accumulation,|                                                                          |             
           Hyaline Droplet                 | 2  2  3  2  1     2     3  2     3  2  1  1  2     2  2  2  2  1        2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 2                 3        2                                             |             
      Inflammation, Suppurative            |                                                 4                        |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  2  1  2  1  1  2  1  2        1  1  1     1  3  1  1  1  1  1  1  1  1|             
      Renal Tubule, Hypertrophy            |                                                                2         |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                 +                        |             
      Inflammation, Suppurative            |                                                 4                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Parasite Metazoan                    |             X                                      X                     |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Parasite Metazoan                    |                   X                    X           X                 X   |      7     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X   |     46     |
      Clear Cell Focus                     | X                 X     X        X                                X      |     10     |
      Fatty Change                         |                                           2           2                 2|      6  2.2|
      Hepatodiaphragmatic Nodule           |             X                                            X        X      |      4     |
      Inflammation, Focal, Granulomatous   |       1     2  1  1  1        1        2  1  2  1        1     1  1  1   |     30  1.2|
      Inflammation, Focal, Histiocytic     |       1  1  2  2  1  1  1     1  1     1  1  2  1  1  1     1  2     1   |     39  1.1|
      Mixed Cell Focus                     |                                  X                                       |      1     |
      Bile Duct, Hyperplasia               |                                                                          |      2  1.5|
      Centrilobular, Necrosis              |          1                                                              3|      6  1.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                                +  +              +        +  +   |  15        |
      Fat, Necrosis                        |       2                                2  2              2        2  3   |     14  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |       2           1              2                                       |      7  1.6|
      Basophilic Focus                     |       X                                                                  |      3     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia                          |                                                             2            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                              2                           |      3  1.7|
      Basophilic Focus                     |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                1         |      4  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Ulcer                                |    3                                                                    3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                         3|      3  2.7|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +     +                                                               |   6        |
      Inflammation, Chronic Active         |    2     3                                                               |      6  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1     2  1  1  2  1     1  1  1        1  1  2  1     3     1     1     2|     33  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                      2                 2     4                           |      5  2.4|
      Hyperplasia                          |          2  1     2                    2        1           2  1  2  1   |     18  1.6|
      Hypertrophy                          | 1     1     2        1           1        1                       2      |     11  1.6|
      Necrosis                             |                                                                         3|      1  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1        2           1        2              2              1     1      |     12  1.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |       1     3        3        3  1                 1  2     1        3   |     19  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      C-Cell, Hyperplasia                  | 3     1        1  2  1  3     2  1  1  2  3     2  1     1     2  3  2   |     36  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |       1                    3                       3                 2   |      5  2.0|
      Inflammation, Chronic Active         |                                           3     3                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                 2              3         |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                               4                                          |      1  4.0|
      Hyperplasia, Cystic                  |             4                                                            |      1  4.0|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |             +  +           +     +     +  +           +                 +|  15        |
      Iliac, Inflammation, Suppurative     |                                                                          |      1  4.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                        2                                 |      1  2.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  M  M  M  M  M  +  M  M  +  M  M  M  M  M  +  +  +  +  +  +  M|  18        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |    3     4                          3              2                     |      7  3.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                              3                           |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    4                                                                     |      1  4.0|
      Osteopetrosis                        |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1     1  1  2  1  1   |     46  1.0|
      Inflammation, Chronic Active         |                         1           1  1                    1        1   |      8  1.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1           4  1  1                    1           2                 1   |     11  1.5|
      Bronchiole, Hyperplasia              |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |    2     1                                2     2     2                 2|     10  1.6|
      Thrombosis                           |                                                                         1|      1  1.0|
      Respiratory Epithelium, Accumulation,|                                                                          |            |
           Hyaline Droplet                 | 2     2  3  2  2  3     1     1  2  3  1  1  3  1  1  1  1  3  2  4  2   |     40  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |    +        +                                                            |   2        |
      Cataract                             |    3        4                                                            |      2  3.5|
      Cornea, Inflammation, Suppurative    |    4                                                                     |      1  4.0|
      Retina, Atrophy                      |    4        4                                                            |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   1        |
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 2| 2| 0| 3| 2| 3| 4| 3| 9| 2| 3| 9| 3| 3| 2| 9| 2| 3| 4| 3| 3| 0|            |
                                           | 0| 4| 1| 6| 9| 2| 1| 9| 0| 3| 1| 7| 7| 1| 7| 1| 1| 6| 6| 8| 1| 2| 0| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infarct                              |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |             2                                                            |      1  2.0|
      Nephropathy                          | 2     1  1  2  2  1  1  1     1  1  1  1  1  3  2  1  1     1  1  2  1   |     43  1.3|
      Renal Tubule, Hypertrophy            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|             
                                           | 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                    X                                X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X     X                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X     X              X        X        X                    X  X        X|             
      Fatty Change                         |    3                       2        4     3                       3      |             
      Hepatodiaphragmatic Nodule           |                   X                    X                                 |             
      Inflammation, Focal, Granulomatous   | 1     2  1     3  1  1  1     2  1  1           1     1  1  1  1     1  1|             
      Inflammation, Focal, Histiocytic     | 1     2  1        1           2  1     1     1  2     1  1  1  1  1  2  1|             
      Mixed Cell Focus                     | X        X           X                          X           X           X|             
      Necrosis                             |                   3                                                      |             
      Tension Lipidosis                    |                                                                          |             
      Bile Duct, Hyperplasia               |                            1                                             |             
      Centrilobular, Necrosis              |    1        1                       2     2        2                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +           +  +                       +     +        +     +           +|             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        | 2           2  2                       2     2        2     3           2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1                 1  1     1                          1  1         |             
      Basophilic Focus                     |          X                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|             
                                           | 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1              1                 3                                 |             
      Basophilic Focus                     |       X                       X                             X            |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            2                          3                  |             
      Ulcer                                |    4                                      3                       3      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                     1                                    |             
      Neuroendocrine Cell, Hyperplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Inflammation, Chronic Active         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     1  2  1  1  2  1     2  1  2  2  1     2  1     2  1  1  1  1  1  1|             
      Atrium, Thrombosis                   |                                     1  1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                        4                                 |             
      Degeneration, Cystic                 |                   2                                                      |             
      Hyperplasia                          | 2        2     2  2  1        2  2              1        2           2  2|             
      Hypertrophy                          | 2     2        1                       2     3        2  2  2           2|             
      Necrosis                             |                                     3     2                              |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|             
                                           | 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |                2  1        1     1           1              1            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           | 3     2  3  2        3        1  1              2        3     1        3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1  1     1  4  1     2  2  2              2     1  1  1  2  1  2  1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                 3  2                                               3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +        +              +           +  +                          +   |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                        3                                 |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|             
                                           | 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | M  M  M  M  +  M  +  M  M  M  +  +  M  M  +  M  M  M  M  M  +  +  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   4              2  4        2                           |             
      Inflammation, Granulomatous          |                3                                                         |             
      Necrosis                             |                                           2                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                        2                          3      |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1|             
      Inflammation, Chronic Active         |                                                                      1   |             
      Metaplasia, Osseous                  |                                                                   1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 2| 3| 8| 3| 1| 3| 6| 8| 3| 3| 8| 2| 3| 2| 2| 1| 3| 3| 3| 3| 2| 3| 3|             
                                           | 0| 5| 9| 1| 5| 0| 7| 0| 8| 5| 1| 1| 0| 9| 4| 5| 9| 7| 1| 0| 1| 0| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                    1                                      1  3  1  1   |             
      Bronchiole, Hyperplasia              |          3                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1        1           2                     |             
      Thrombosis                           |    2        3                       2                                    |             
      Respiratory Epithelium, Accumulation,|                                                                          |             
           Hyaline Droplet                 |       1  3  2  1  2  1  1     3  3  1  2  1  2  2     2     2     1  2  1|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Inflammation, Chronic Active         |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |    2                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 1  2  1  1     2  3  1  1  2  2  2  1  1  1  1  1     1  1  1  1  1  1  2|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Transitional Epithelium, Hyperplasia |                            1                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                    X                     |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                          X     X     X   |      5     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  41        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    1        1            |      2  1.0|
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X|     46     |
      Clear Cell Focus                     | X                          X  X              X     X           X  X     X|     16     |
      Fatty Change                         |          3                       2  1                                2   |      9  2.6|
      Hepatodiaphragmatic Nodule           | X  X  X                                      X              X            |      7     |
      Inflammation, Focal, Granulomatous   |    1  2     1  1        1  1  1        1  1  1     1  1        1  1  1  1|     33  1.2|
      Inflammation, Focal, Histiocytic     | 1  1  2     1  1  1  1  1  1  1        1  1  1     1  1  1  1  1  1  1  1|     37  1.1|
      Mixed Cell Focus                     |                   X                                                      |      7     |
      Necrosis                             |                                                                          |      1  3.0|
      Tension Lipidosis                    |                                        X                                 |      1     |
      Bile Duct, Hyperplasia               |                                     1                          1         |      3  1.0|
      Centrilobular, Necrosis              |    2     2                                                  2            |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +  +           +                          +  +                     |  13        |
      Fat, Hemorrhage                      |                      3                                                   |      1  3.0|
      Fat, Necrosis                        |       2  2           2                          2  2                     |     13  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |       1     4                          1           1                     |     10  1.3|
      Basophilic Focus                     |                                              X                           |      2     |
      Hyperplasia                          |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               1                                          |      4  1.5|
      Basophilic Focus                     |                                                                          |      3     |
      Inflammation, Suppurative            |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                  2                                       |      3  2.3|
      Ulcer                                | 2                                               3                    3   |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Hypertrophy, Focal                   |                                              2                           |      1  2.0|
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Mineralization                       |                                              1                           |      1  1.0|
      Necrosis                             | 1                                                                        |      2  1.0|
      Neuroendocrine Cell, Hyperplasia     |                                                                   4      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   2        |
      Inflammation, Chronic Active         | 4                                                                        |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  1  3  1  1  1     1  1  1        1  1  1     1  1  2  1  1  1  1  1|     42  1.3|
      Atrium, Thrombosis                   |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Angiectasis                          |                                                             3            |      1  3.0|
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                                                   2      |      2  2.0|
      Hyperplasia                          |             2  2  2  1     1  3     2  2     2              2  2  2  2   |     24  1.9|
      Hypertrophy                          | 2              2                                   1     1        2      |     14  1.9|
      Necrosis                             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 2                    2                                                   |      8  1.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  A  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                              1                           |      1  1.0|
      Pars Distalis, Hyperplasia           |                               2                       4     2     2      |     15  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      C-Cell, Hyperplasia                  | 2     2     3  2  2  1     2  1  1     1  1        2  2  3  1  1  3  3  1|     36  1.7|
      Follicular Cell, Hyperplasia         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |                                           3        1                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             2                                   3                        |      6  2.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |             +        +        +                       +        +         |  11        |
      Mediastinal, Ectasia                 |                               2                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  +  +  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  M|  12        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                     3                       3           2|      7  2.9|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                   2      |      3  2.3|
      Inflammation, Chronic                |                                                                      4   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                       3  3               |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|     47  1.0|
      Inflammation, Chronic Active         |                1           1                          1                  |      4  1.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                   1        1     1        1  1           1        1  1  1|     15  1.1|
      Bronchiole, Hyperplasia              |             1                                                            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            | 4     2                                                                  |      5  2.0|
      Thrombosis                           |          2                                                               |      4  2.3|
      Respiratory Epithelium, Accumulation,|                                                                          |            |
           Hyaline Droplet                 |       4  1  2  4  4  2  2  4     3  2     1  2        3  3  3  2     1   |     36  2.1|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 4| 7| 7| 7| 5| 4| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 2| 2| 1| 3| 3| 3| 4| 2| 3| 3| 8| 4| 3| 3| 2| 2| 3| 3| 3| 2| 3| 2| 3| 2|            |
                                           | 3| 1| 9| 7| 0| 1| 0| 2| 5| 0| 1| 5| 1| 1| 0| 9| 4| 0| 1| 1| 9| 0| 9| 0| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                      2                                                   |      1  2.0|
      Infarct                              |                                                    2                     |      2  2.0|
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
      Nephropathy                          | 2     2     2  1  2  2  1  1  1  2  1  1  1  1     2  2  2  1  1  1  1  1|     45  1.4|
      Pelvis, Inflammation, Acute          |                                                    2                     |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X  X     X     X           X  X  X                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X  X  X     X           X  X  X        X           X        X  X  X   |             
      Eosinophilic Focus                   |                                                                         X|             
      Fatty Change                         |                                                          2               |             
      Hepatodiaphragmatic Nodule           |                                        X                             X   |             
      Inflammation, Focal, Granulomatous   | 2  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  1  1  2     1  1  1  1   |             
      Inflammation, Focal, Histiocytic     | 1  1  1  1  1     1  1  1  1  1  1     1  2  1  1  1  2     1  1  1      |             
      Mixed Cell Focus                     | X                 X        X     X                                       |             
      Bile Duct, Hyperplasia               |                                                    1                    2|             
      Centrilobular, Necrosis              |                                                                         1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                               +           +        +     +        +      |             
      Fat, Necrosis                        |                               3           2        2              3      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                       1                    2                    1   |             
      Basophilic Focus                     |          X                                                     X     X   |             
      Hyperplasia                          |             1     2                                   2                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              |       1                 1                                                |             
      Basophilic Focus                     |    X                 X        X                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Inflammation, Chronic Active         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  1  1  1  1  1     1  1        1  2  2     1  1  1  1        1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |    2  3     2  2  2  2  2  1           2  2     2  2        3        2  2|             
      Hypertrophy                          |                                              2  2                 2  2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |    2                          3                                   1  2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3                                       |             
      Pars Distalis, Hyperplasia           |    4     1  2  2  2        1  2  2     1           2        4        4   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  2  2  2  1  2  2     1  1  2     1  1  1  1  1        2  1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                       3              3                          3     4|             
      Interstitial Cell, Hyperplasia       |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                                            +        +              +|             
      Deep Cervical, Ectasia               |    2                                            1                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  +  M  +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Inflammation, Granulomatous          |                                                       4                  |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Fibrosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1|             
      Inflammation, Chronic Active         |    1                       1                    1                       1|             
      Metaplasia, Squamous                 |                                                                      2   |             
      Alveolar Epithelium, Hyperplasia     |    2                 1        4        1  1  1  1  1  1              1  2|             
      Bronchiole, Hyperplasia              |          1  1                 1                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                1           1              1                             1|             
      Olfactory Epithelium, Atrophy        |                                                                         1|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                    4                     |             
      Respiratory Epithelium, Accumulation,|                                                                          |             
           Hyaline Droplet                 | 2  1  1  2  2  2  2     2  1  2  1  2  3           2  1     2     2  2   |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3|             
                                           | 0| 1| 0| 9| 1| 9| 0| 1| 1| 9| 1| 1| 8| 0| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                     +     +                              |             
      Cataract                             |                                     2     4                              |             
      Retina, Atrophy                      |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  2  2  1  1  1  1  2  1  1  2  1  1  2  1  1  1  1  1     2  1  2  1  1|             
      Pelvis, Inflammation, Acute          |       3                                                                  |             
      Transitional Epithelium, Hyperplasia |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    X                                                                     |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |             X              X  X        X           X  X                  |     13     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|     49     |
      Clear Cell Focus                     |    X        X        X  X  X  X                       X                  |     20     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         | 2     1        1                    2                                   2|      6  1.7|
      Hepatodiaphragmatic Nodule           |          X     X                       X  X                              |      6     |
      Inflammation, Focal, Granulomatous   | 1  1  1                    1     1     1        1  1  1  2  1  1  1  1   |     37  1.1|
      Inflammation, Focal, Histiocytic     | 1  1  1     1  1     1  1  1  1                 1     1  2  1  1  1  1   |     36  1.1|
      Mixed Cell Focus                     | X  X                                                        X            |      7     |
      Bile Duct, Hyperplasia               |                      1  1                 1     1                    1   |      7  1.1|
      Centrilobular, Necrosis              |                                     1                                    |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +  +                          +           +        +  +     +      |  13        |
      Fat, Necrosis                        | 2     2  2                                      2        2  2     2      |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                     4                 1                  |      6  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Basophilic Focus                     |                                                                          |      3     |
      Hyperplasia                          |                                                                      2   |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             1                                                            |      3  1.0|
      Basophilic Focus                     |                      X                                X                  |      5     |
      Inflammation, Suppurative            | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                               1                 1                    1   |      3  1.0|
      Ulcer                                |       3                                                                 3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                     2        1                           |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                      +   |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  1     1     1        1  2        1  2  1  1  1                 1   |     32  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                     3                                    |      1  3.0|
      Hyperplasia                          |    1        2     2        2        2              3  2  1  2  2         |     25  2.0|
      Hypertrophy                          | 1                 2     1  3                       2              3  1   |     12  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                   2           2           1        2     1        2      |     10  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     2        2                           |      3  2.3|
      Pars Distalis, Hyperplasia           | 2  2        1              2  2  2     3  2        2                    2|     22  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  | 1  1  2     1     2  2     2  2  1     1  2     1     1  1        1  1  1|     38  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia                          | 3                                                     2        1         |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |       3                    4                                             |      7  3.1|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                       +  +                                   +|   8        |
      Deep Cervical, Ectasia               |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  M  M  +  +  M  M  M  M  M  +  +  M  M  M  M  M  +  M|  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                                                 X                        |      1     |
      Hematopoietic Cell Proliferation     |                3                    3     2                              |      4  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Necrosis                             |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Fibrosis                   |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst, Squamous                       |                                                                   3      |      1  3.0|
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1|     46  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 5| 2| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 6| 3| 9| 9| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 1| 6| 8| 3| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 7| 0| 7| 5| 1| 4| 1| 0| 9| 0| 0| 0| 8| 0| 7| 5| 1| 0| 1| 1| 9| 0| 5| 9| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation, Chronic Active         |                   1              1                             1  1      |      8  1.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                   1     1  1  1           4              1               |     17  1.5|
      Bronchiole, Hyperplasia              |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                        1                       2     1   |      7  1.1|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                2         |      1  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                                                          |      1  4.0|
      Respiratory Epithelium, Accumulation,|                                                                          |            |
           Hyaline Droplet                 | 2  1        1  2  2  2  1  2  3  2     3  2     2  3  2        2  2  3  2|     37  1.9|
      Respiratory Epithelium, Hyperplasia  |    4                                                                     |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                   2                                                      |      1  2.0|
      Infarct                              |                2                                                         |      1  2.0|
      Nephropathy                          | 1  2  1     1  1  2  2  1  2  2  1  1  1  1     1  1  1  1  1  2  1  2  1|     47  1.3|
      Pelvis, Inflammation, Acute          |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|             
                                           | 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    | X                                                                    X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |       X                                                  X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X  X        X        X        X  X     X  X           X  X           X   |             
      Eosinophilic Focus                   |                                                             X  X         |             
      Fatty Change                         |          2                          3                                    |             
      Hepatodiaphragmatic Nodule           |             X                                            X              X|             
      Inflammation, Focal, Granulomatous   | 1  1  1  1  2        1     1  2        1           1        1  1  1  1  3|             
      Inflammation, Focal, Histiocytic     | 1  1  1     1     2  1     1  1        1  1              1        1  1  1|             
      Mixed Cell Focus                     |                            X     X                       X               |             
      Bile Duct, Hyperplasia               |    1           1     1           1        1     2  1     1           1   |             
      Centrilobular, Necrosis              |                         2           1           2              1         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                                   +  +           +           +|             
      Fat, Necrosis                        |                                              2  3           2           2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1     1     1                       2  2     2        1|             
      Basophilic Focus                     |                                        X                                 |             
      Hyperplasia                          |                            2     2                       3               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|             
                                           | 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Inflammation, Suppurative            |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                         3           2                                    |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  1  2        1        1     2  1  1  1  1     2  1  1  1     2  1  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1  2     2                 2        3  2  1  1            |             
      Hypertrophy                          |    2                                      2                    1        2|             
      Necrosis                             |          2              3                                                |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     2                                                                  |             
      Necrosis                             |                         4                                                |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                     2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|             
                                           | 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
      Cyst                                 |                                                       3                  |             
      Pars Distalis, Hyperplasia           |                   2  3  2  2  2  2  2     4        2     4  4           1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
      C-Cell, Hyperplasia                  |          1  1              1     1  1  1  1           1  1  1  1     2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Chronic Active         |                                                             3            |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2        2                       3                 3|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +  +           +  +                       +           +           +|             
      Deep Cervical, Hyperplasia           |                      2                                                   |             
      Mediastinal, Ectasia                 |       2                                                                  |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  M  M  +  M  M  M  M  M  M  M  M  M  +  +  +  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|             
                                           | 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                4         |             
      Hemorrhage                           |                                              3                           |             
      Inflammation, Granulomatous          |                               4                                         4|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  A  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                       3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1  1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1  1|             
      Inflammation, Chronic Active         | 1  1  1                 1                 1                          1   |             
      Alveolar Epithelium, Hyperplasia     | 2           1                                      3                     |             
      Bronchiole, Hyperplasia              |                                                          1               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                2         |             
      Thrombosis                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 6| 3| 3| 1| 3| 9| 3| 3| 3| 2| 3| 2| 5| 8| 3| 2| 3| 3| 4| 1| 2| 3|             
                                           | 9| 1| 1| 8| 0| 0| 8| 1| 4| 1| 0| 0| 6| 0| 9| 9| 1| 1| 9| 0| 1| 2| 1| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Degeneration   | 1  2        2                                   1              3         |             
      Olfactory Epithelium, Metaplasia     |                                                                1         |             
      Respiratory Epithelium, Accumulation,|                                                                          |             
           Hyaline Droplet                 | 4  3  2  2  3  3  3  3  3  2  3  3  2  2  3     2  2  3  4  2  2  3  2  2|             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +                    +                          +                        |             
      Cataract                             |                                                 4                        |             
      Degeneration                         | 4                    4                                                   |             
      Retina, Atrophy                      |                      4                          4                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 2        3              3           2                                    |             
      Nephropathy                          | 3  2  1  1  2  1  4  1  2  2  1  2  2  2  1     2  2  2  1  2  2  2  2  1|             
      Transitional Epithelium, Hyperplasia | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |             1                                                            |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                                 X                        |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  45        |
      Necrosis                             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X  X     X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X  X     X  X|     46     |
      Clear Cell Focus                     | X                                   X  X  X     X     X                  |     17     |
      Eosinophilic Focus                   |                         X              X                                 |      4     |
      Fatty Change                         |                                  3                                3      |      4  2.8|
      Hepatodiaphragmatic Nodule           |    X           X                                         X               |      6     |
      Inflammation, Focal, Granulomatous   | 1              2  1  1  1     1           2  1     1        1           1|     26  1.2|
      Inflammation, Focal, Histiocytic     | 1  1           2  1  2  1     1     1  1  1  1     1     1              1|     28  1.1|
      Mixed Cell Focus                     |                      X                                                   |      4     |
      Bile Duct, Hyperplasia               | 1           1           1        1           2  1     1           3     1|     18  1.2|
      Centrilobular, Necrosis              |             1                                                     1      |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +     +  +                                   +        +            |  11        |
      Fat, Necrosis                        | 2           2  2                                   2                     |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Atrophy                              |                                                    1           1     2   |     10  1.4|
      Basophilic Focus                     |                                     X  X                                 |      3     |
      Hyperplasia                          |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Squamous                |                               3                                   2      |      2  2.5|
      Ulcer                                |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                                                    1                     |      1  1.0|
      Necrosis                             |             1                                            2               |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                          +               |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1              2                 1  1  1  1  1  2  1                  |     26  1.3|
      Atrium, Thrombosis                   |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                   1     2                          1     2              1|     13  1.6|
      Hypertrophy                          | 1           1                             3                 1     2      |      9  1.7|
      Necrosis                             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                               2        2                    1     2     1|      7  1.9|
      Necrosis                             |                                                                      4   |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                              2                           |      2  1.5|
      Cyst                                 |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |    2        1                    4     3  4           3                 3|     19  2.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  | 1              1     1  1     2  1  2  1  1  2  1  1  1     1        1   |     28  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |                         2           2                                    |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |             2                          2                       3        3|      8  2.5|
      Inflammation, Granulomatous          |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +        +     +     +                    +  +   |  14        |
      Deep Cervical, Hyperplasia           |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  M  +  M  M  M  M  A  +  M  M  M  M  M  M  M  M  M  +  +  +  +  +|  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                             3            |      2  3.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                              2                           |      3  3.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  M  +  A  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1     1  1|     45  1.0|
      Inflammation, Chronic Active         |                         1              1  1           1        1         |     11  1.0|
      Alveolar Epithelium, Hyperplasia     | 1        1     1                    1              1                     |      8  1.4|
      Bronchiole, Hyperplasia              | 1                                                                        |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   2           2                       2                  |      4  2.0|
      Thrombosis                           |             2                    1                       2               |      3  1.7|
      Olfactory Epithelium, Degeneration   |             3                 3  3                          4            |      9  2.4|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
      Respiratory Epithelium, Accumulation,|                                                                          |            |
           Hyaline Droplet                 | 2  3     2  2  2  1  2  2     3  2  4  3  2  2  3  2  2     2  2  3  4  4|     46  2.5|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  4.0|
      Degeneration                         |                                                                          |      2  4.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 5| 7| 7| 5| 7| 5| 6| 5| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 3| 3| 9| 3| 3| 7| 3| 8| 2| 9| 3| 3| 3| 3| 3| 2| 3| 6| 9| 5| 2| 3| 2|            |
                                           | 0| 9| 3| 6| 7| 0| 0| 7| 1| 2| 6| 7| 0| 1| 0| 0| 0| 9| 1| 4| 4| 2| 5| 0| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Infarct                              |                                                                          |      4  2.5|
      Nephropathy                          | 2  1     1  2  1  1  3  2     4  2  2  2  2     2  2  2  1  2  2  2  2  2|     46  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  I  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|             
                                           | 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +|             
      Parasite Metazoan                    |             X                 X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +|             
      Parasite Metazoan                    |                            X        X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  A  +  A  +  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  A  +  A  +  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X  X  X  X  X     X        X  X                 X     X        X|             
      Clear Cell Focus                     | X  X     X  X  X  X  X              X                    X  X  X        X|             
      Degeneration, Cystic                 |    1              2                                            2         |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                                                             1            |             
      Hepatodiaphragmatic Nodule           |                                           X                              |             
      Inflammation, Focal, Granulomatous   | 1  1     1  1     1              1  1                 1     1  1  1     1|             
      Inflammation, Focal, Histiocytic     | 1  1     1  1     1              1  1        2        1        1  1     1|             
      Regeneration                         |                            2                                         2   |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  2  1  1  1  1        2  2     1  3     1  3     1     1  2     3   |             
      Centrilobular, Necrosis              |       2                    2  1        1  3     3                    2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +        +     +              +        +  +  +                        |             
      Fat, Inflammation                    |                                  3                                       |             
      Fat, Necrosis                        |    2        2     2              3        2  2  2                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Necrosis                 |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|             
                                           | 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +|             
      Atrophy                              |    3  2        1     1              3  2     2                           |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                2     2                                                   |             
      Artery, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Squamous       |                                                       2                  |             
      Ulcer                                |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
      Necrosis                             |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Inflammation, Chronic Active         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                     +                                    |             
      Inflammation, Granulomatous          |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     3  2  3  2  1  2     2  2     2  2  2  2  1  2  2  2  2  2  2     2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Degeneration, Cystic                 |    2                                                                     |             
      Hyperplasia                          | 2  2     1  2     2        2        1                    2     1        2|             
      Hypertrophy                          | 2              3           2                          1                  |             
      Necrosis                             |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|             
                                           | 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hyperplasia                          |    2  3        3     1     1  3     4  3                    3     1      |             
      Necrosis                             |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia           |                      3              2                       1            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +|             
      C-Cell, Hyperplasia                  |    1  2  1  1  2     1     1                    2        1              1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          | 4                 3  2                                         1         |             
      Inflammation, Chronic Active         |          2  2                                3           2               |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4                                                                        |             
      Interstitial Cell, Hyperplasia       |    2           1           1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|             
                                           | 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +              +        +        +        +  +     +     +         |             
      Mediastinal, Ectasia                 |                                                                2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  +  M  M  M  M  +  M  M  +  M  M  +  M  M  +  +  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  A  A  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |    3                                                                     |             
      Fibrosis                             |                            1                    1                        |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Focal, Lymphoid         |          2                                                              2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  I  +  +  +  M  M  +  +  M  +  M  +  +  +  +  A  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Galactocele                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      3   |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 5| 5| 5| 3| 7| 6| 5| 5| 5| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 5| 2| 2| 9| 2| 2| 8| 6| 6| 7| 3| 9| 1| 6| 6| 7| 5| 2| 2| 2| 3| 7| 2|             
                                           | 0| 0| 3| 9| 9| 8| 9| 9| 2| 5| 8| 6| 0| 7| 1| 9| 4| 9| 3| 9| 9| 9| 6| 3| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1        1  1           1  1        1     1  1  1  1  1     1|             
      Inflammation, Chronic Active         |                      2                                      1            |             
      Metaplasia, Squamous                 |       1                                                                  |             
      Alveolar Epithelium, Hyperplasia     |    1  2  1  4  1                                      2     1            |             
      Mediastinum, Necrosis, Fatty         |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Suppurative            |          2                 1     1        2     3                        |             
      Thrombosis                           |                                                                          |             
      Olfactory Epithelium, Atrophy        |       1                    1                    2                        |             
      Olfactory Epithelium, Metaplasia     |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Cataract                             |                         3                                                |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Infarct                              |                                        3  4                              |             
      Nephropathy                          | 2  2     2  3  3  2  2     2  2  1  2  2     1  2  1  2  3  2  3  2     2|             
      Pigmentation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  A  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Parasite Metazoan                    |                X                                   X                     |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  A  +  A  A  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Parasite Metazoan                    |                X                             X              X  X         |      6     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  37        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  37        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X        X        X           X  X        X  X     X  X        X  X|     24     |
      Clear Cell Focus                     | X              X        X           X        X  X  X        X        X  X|     22     |
      Degeneration, Cystic                 |                                                 2                        |      4  1.8|
      Eosinophilic Focus                   |                                        X                                 |      1     |
      Fatty Change                         |          2        2  3                    1           2                  |      6  1.8|
      Hepatodiaphragmatic Nodule           |                         X                                            X   |      3     |
      Inflammation, Focal, Granulomatous   |                2        1           1  1     1     1     1  1        1  1|     22  1.0|
      Inflammation, Focal, Histiocytic     | 1     1        1        1                                      1     1   |     18  1.1|
      Regeneration                         |                            2                                             |      3  2.0|
      Thrombosis                           |                      1                                                   |      1  1.0|
      Bile Duct, Hyperplasia               | 1  2           1  1        2  2        2  1  1  1  1  2  1  1  3  2  1   |     34  1.5|
      Centrilobular, Necrosis              |    1     1        2  3     3  1                                1  2      |     15  1.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +     +        +  +  +                       +                 +      |  14        |
      Fat, Inflammation                    |                                                                          |      1  3.0|
      Fat, Necrosis                        |    2     2        2     2                                         3      |     12  2.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                         +|   1        |
      Pharyngeal, Necrosis                 |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Atrophy                              | 2  2     2                          1  2  2        1  1        2        2|     17  1.8|
      Basophilic Focus                     |                                                                      X   |      1     |
      Hyperplasia                          | 2                 2     2     2                          2               |      7  2.0|
      Artery, Inflammation                 |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                          2               |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Diffuse, Squamous       |       2                                                                  |      2  2.0|
      Ulcer                                |       2                    3                                             |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Necrosis                             |    1     1  4              2                                             |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     2        1  2  1  2     1  2  2  2     1  1  2  2  2  3  2  2  1  2|     41  1.9|
      Hemorrhage                           |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          | 1              2                                         2           2  2|     15  1.7|
      Hypertrophy                          |                                                                         2|      5  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       2  3     2        4     1     3        3  3  1     4  1     3  2   |     23  2.4|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  A  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |                                        2                                 |      1  2.0|
      Pars Distalis, Hyperplasia           |                         2     1     3                 1        2        3|      9  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      C-Cell, Hyperplasia                  |       1        1        1     1     1  1     1  1  1  1     1  1  1  1   |     24  1.1|
      Follicular Cell, Hyperplasia         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                   +  +                                         +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |    1        2           4                    1  4              2     1   |     11  2.3|
      Inflammation, Chronic Active         |                2                                   2           2  3      |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                   3      |      2  3.5|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +                 +  +        +  +                 +  +  +      |  18        |
      Mediastinal, Ectasia                 |                                                             3            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  +  M  M  M  M  +  A  M  M  M  +  M  +  M  +  +  M  M  M  M  M  M|  13        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Atrophy                              | 2                                                                        |      1  2.0|
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |    2     2                             2                          2      |      6  1.7|
      Hematopoietic Cell Proliferation     |                                                       2                  |      2  2.0|
      Hemorrhage                           |                               3                                          |      2  2.5|
      Hyperplasia, Focal, Lymphoid         |                2                    2                                    |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  39        |
      Hemorrhage                           |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                          4               |      1  4.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1     1           1     1     1     1  1  1  1        1  1  1  1  1  1  1|     32  1.0|
      Inflammation, Chronic Active         |                                                          1               |      3  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                4                    1           2                       2|     11  1.9|
      Mediastinum, Necrosis, Fatty         |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                3                       2           2  1     3           2|     11  2.0|
      Thrombosis                           |                   2  4                                                   |      2  3.0|
      Olfactory Epithelium, Atrophy        |                1                                                         |      4  1.3|
      Olfactory Epithelium, Metaplasia     |                2        1                                   2            |      4  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 3| 7| 6| 6| 7| 6| 7| 2| 7| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 1| 6| 9| 1| 2| 2| 8| 7| 3| 4| 3| 6| 2| 2| 8| 2| 5| 3| 6| 2| 2| 3| 9| 2| 2|            |
                                           | 8| 7| 7| 7| 3| 9| 7| 6| 0| 5| 0| 1| 9| 9| 4| 9| 4| 0| 4| 9| 9| 0| 8| 9| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                          +               |   2        |
      Cataract                             |                                                          4               |      2  3.5|
      Retina, Atrophy                      |                                                          4               |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Infarct                              |          2                                                               |      3  3.0|
      Nephropathy                          | 2     3  2     2        2     3  1  2  2  1  3  3  3  2  2  3  2  2  2  2|     41  2.1|
      Pigmentation                         |                      2                                                   |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X           X  X        X  X  X  X  X  X  X  X  X  X  X  X        X  X|             
      Clear Cell Focus                     |    X           X  X        X  X        X        X     X     X           X|             
      Degeneration, Cystic                 |                                              2                           |             
      Fatty Change                         |          3                       1                                       |             
      Hepatodiaphragmatic Nodule           |                X     X                 X                 X           X   |             
      Inflammation, Focal, Granulomatous   | 1  1           1  1                    1  1     1     1     1     1  1  1|             
      Inflammation, Focal, Histiocytic     | 1  1           1  1           1           1           2           1  1  1|             
      Mixed Cell Focus                     | X                                                                        |             
      Vacuolization Cytoplasmic, Focal     |       2                                                                  |             
      Bile Duct, Hyperplasia               | 2  1  1  2  1  1  1  2  2  1  2  1     1  1  1        2  2  1  3  2     1|             
      Centrilobular, Necrosis              |       1  1           2  1           3                          2  2      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +        +     +        +     +                 +     +   |             
      Fat, Necrosis                        |                2        2     2        2     3                 2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2     4              2  2     2                             1   |             
      Basophilic Focus                     |                               X                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hyperplasia                          |          3     2                 4        2                              |             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                2                                 |             
      Basophilic Focus                     |    X                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |          2           3              2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                                                          |             
      Mineralization                       |                                  2                                       |             
      Necrosis                             |          2           3           2                                2      |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  3  1  2  2  3     1  2  2     2  2  1  2  1  2     2  2     1  1|             
      Atrium, Thrombosis                   |          3           2                                            2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        2  1     2              2     2  1  2        2           2  1|             
      Hypertrophy                          |       2        2                                2                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                2         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4  1  3        3  2           1     3        1  4     2  1  3        2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2  2           3                    3      |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 1                                                                        |             
      Pars Distalis, Hyperplasia           | 2  3  2           1        3                       2  1     2  2  2  2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1                    3  2  1     1     2  1  2  1  1  1     2     2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             1        2   |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  1                    3                    4                 1     3|             
      Inflammation, Chronic Active         |    2     3                    2           2                              |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Interstitial Cell, Hyperplasia       |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +           +     +           +                 +  +     +  +      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  +  +  +  M  M  M  M  +  M  +  +  M  +  M  +  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2  2           2                                3           2      |             
      Hematopoietic Cell Proliferation     |                                  3                 3                     |             
      Hyperplasia, Focal, Lymphoid         | 4              2  3                                                      |             
      Necrosis                             |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hyperkeratosis                       |          3        3                                                      |             
      Hyperplasia, Basal Cell              |                         1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Inflammation, Suppurative   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                   2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   X                                                      |             
      Infiltration Cellular, Histiocyte    | 1  1  1        1     1     1     1     1  1  1  1  1  1     1  1  1  1   |             
      Inflammation, Chronic Active         |                   2                                                      |             
      Metaplasia, Squamous                 |                                                                         2|             
      Mineralization                       |                                  2                                       |             
      Thrombosis                           |                                                    1              1      |             
      Alveolar Epithelium, Hyperplasia     |    1           1        4  3     3     1     4        1              1  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |    2                                         1  2     2        2  2      |             
      Thrombosis                           |          3           1                                            2      |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |                                                                   2      |             
      Olfactory Epithelium, Atrophy        |       2  1                                      1                        |             
      Olfactory Epithelium, Metaplasia     |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cataract                             |                                           3                              |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Retina, Atrophy                      |                                           4                              |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                  3                                       |             
      Infarct                              |          2           3                                            2      |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                  2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 6| 6| 5| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 1| 3| 2| 8| 4| 3| 2| 2| 5| 2| 2| 9| 3| 5| 3| 2| 2| 4| 6| 6| 2|             
                                           | 9| 9| 0| 9| 7| 0| 9| 0| 9| 0| 9| 6| 0| 9| 9| 8| 0| 6| 0| 9| 9| 9| 1| 4| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.25%                                  | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Nephropathy                          | 2  3  2  3  1  2  4     1  2  2  3     4  3  1  2  1  3  2  2  2  2  2  2|             
      Pigmentation                         |          3                                                           3   |             
      Papilla, Necrosis                    |                                  2                                       |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Inflammation, Chronic Active         |                                  3                                       |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                    X                     |      1     |
      Ulcer                                |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  X                                       |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Ulcer                                |                                                       4                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  A  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X     X  X        X  X     X  X        X     X  X  X  X     X|     35     |
      Clear Cell Focus                     | X  X        X     X  X  X     X  X                 X     X     X        X|     22     |
      Degeneration, Cystic                 |             1                                2                           |      3  1.7|
      Fatty Change                         |                                                       3     2        2   |      5  2.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Inflammation, Focal, Granulomatous   | 1  1  1  1  1     1  1  1     2  2        1        1     1              1|     26  1.1|
      Inflammation, Focal, Histiocytic     |       2  1  1  2  1     1  1  1  1        2  2  1  1     1  2  2  1      |     27  1.3|
      Mixed Cell Focus                     |                               X                                          |      2     |
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1     1  1  1  1  1  1  1                 2  2        2  1  2  1  2  3  2|     38  1.5|
      Centrilobular, Necrosis              |                                     3                       1     2  1   |     11  1.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                     +        +     +              +      |  11        |
      Fat, Necrosis                        |                                              3     3              3      |      9  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 3        1  1  1  2  2  1     2  2     1        2     4     2  3         |     20  2.0|
      Basophilic Focus                     |    X                                                                     |      2     |
      Hyperplasia                          |                                                    2              2      |      6  2.5|
      Thrombosis                           |                                                                   1      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Atrophy                              |                               2              2           2               |      5  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Inflammation, Suppurative            |                                              1                           |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                2                                                         |      1  2.0|
      Hyperplasia, Squamous                |                                              3                           |      1  3.0|
      Ulcer                                |                                              3        2                  |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia                           |                                  4                                       |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                              2        2              2   |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  3     2     2  1  2  1  2  2  2  2  2        2  1  1  3  2  3  1  1|     42  1.8|
      Atrium, Thrombosis                   |                                                       2              4   |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2  2        2     3  2  2        2     1                    2  2        2|     22  1.9|
      Hypertrophy                          |       2                                                                  |      4  2.0|
      Inflammation, Granulomatous          |                         1                                                |      1  1.0|
      Necrosis                             |                                           2                 3     3      |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2           2           4     4  3        2           2  2           3   |     23  2.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |          1                                         1                 1   |      4  1.0|
      Pars Distalis, Hyperplasia           |                               3  2        2        1                 2   |     16  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      C-Cell, Hyperplasia                  | 2  3     2  2     2  2  1  1     2                       1     1        1|     26  1.6|
      Follicular Cell, Hyperplasia         |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                     +                                    |   2        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                  2                                       |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                          3                          2     3         |     11  2.5|
      Inflammation, Chronic Active         | 2     2                                   3                    2         |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                           3                              |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3              3                                4                     |      4  3.3|
      Interstitial Cell, Hyperplasia       |                   2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                   +        +     +        +   |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  M  +  M  +  +  M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  +|  16        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Granulomatous          |                                                                   4      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      5  2.2|
      Hematopoietic Cell Proliferation     |                2                       2        3                        |      5  2.6|
      Hyperplasia, Focal, Lymphoid         |                                                                   2      |      4  2.8|
      Necrosis                             |                                              3        2                  |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  M  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  M|  41        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                             X            |      1     |
      Hyperkeratosis                       |             4                    4                                       |      4  3.5|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1     |
      Infiltration Cellular, Histiocyte    | 1  1     1  1     1  1  1  1  1  1     1     1  1        1     1  1  1  1|     35  1.0|
      Inflammation, Chronic Active         |    1                                                                     |      2  1.5|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                2  2     1     2        2                 1     1        2|     18  1.9|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                         X     X                                          |      2     |
      Inflammation, Suppurative            | 1              2        3     3  2  1        2        2     2     1     1|     17  1.8|
      Thrombosis                           |                                     4                                2   |      5  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 5| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 2| 2| 3| 5| 2| 2| 3| 0| 2| 2| 5| 8| 1| 8| 2| 3| 1| 3| 1| 2| 2| 1| 2|            |
                                           | 9| 9| 1| 9| 0| 8| 9| 9| 0| 5| 9| 9| 4| 6| 6| 4| 8| 0| 4| 0| 7| 9| 8| 1| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    0.25%                                  | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      3  1.3|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Cornea, Inflammation, Suppurative    |                3                                                         |      1  3.0|
      Cornea, Mineralization               |                2                                                         |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infarct                              |                                              3        1              2   |      6  2.2|
      Metaplasia, Osseous                  |                               2                                          |      1  2.0|
      Mineralization                       |                2                                                         |      2  2.0|
      Nephropathy                          | 3  2  3  3  3  3  2  3  2  1  4  2     1  1  2  2  2  2  2  2  3  2  2  2|     47  2.2|
      Pigmentation                         |                                                                          |      2  3.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                      1        2                          1               |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                      X              X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                   2                                                      |             
      Ulcer                                |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Basophilic Focus                     | X  X        X  X           X     X  X     X  X  X  X  X  X        X  X   |             
      Clear Cell Focus                     |                X     X     X     X  X        X     X     X        X  X   |             
      Degeneration, Cystic                 |             2              1                                             |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                               3                                1         |             
      Hepatodiaphragmatic Nodule           |                      X  X                                                |             
      Inflammation, Focal, Granulomatous   |    1  2     1  2  3  2  1  2  1  1  2  1  1  2  1  2  1  1     2  1  2   |             
      Inflammation, Focal, Histiocytic     | 2  1  2  2  1  2  2  2  2  2     2  2  1     2  2  2  1  1     2  1  2  2|             
      Mixed Cell Focus                     |                                              X                           |             
      Thrombosis                           |          2                                                               |             
      Bile Duct, Hyperplasia               | 3  1  2  2  2     1  1  1  1  2  1  1  2     1  2  1  1  1     1  1  2  3|             
      Centrilobular, Necrosis              | 1     1  1                    3        2                                1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +                    +        +     +        +            |             
      Fat, Necrosis                        |                2                    2        3              3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2  2  3              3                       2              1     2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                  3                                      2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                        1                                 |             
      Hyperplasia, Diffuse, Squamous       |                                                                          |             
      Hyperplasia, Squamous                |          3                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                   3           3           2                    3         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                               2        2                                 |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                            +                                             |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Inflammation, Chronic Active         |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1  2  2  2  2  1  1  2     2  2  1  2  2  2  2  1  2  3     2  3   |             
      Necrosis                             |                                                                          |             
      Atrium, Thrombosis                   |                               4        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  2     2     1  2           2  1  2  2        1     2     2     2   |             
      Hypertrophy                          |                                                       2           2     2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  2  2  4  2  4  3     2  4              4     2  3           4  2  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |       2  2              1  2           2  2              2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3     2  1  2  1     1  1     1  2  1  2     1     2  1  2     1  1      |             
      Follicular Cell, Hyperplasia         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                              +     +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3                                                  2         |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2     2  2           2        1                                   2|             
      Inflammation, Chronic Active         |    3     1  2        1        3           2                       2      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Interstitial Cell, Hyperplasia       |                                                       2  2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                              1                           |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +     +  +  +                 +  +  +  +           +  +           +     +|             
      Bronchial, Ectasia                   |                                                                   3      |             
      Mediastinal, Ectasia                 |                                     4                                    |             
      Mediastinal, Hyperplasia             |                                  2                                       |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Fibrosis                             |          2                                            2                 3|             
      Hematopoietic Cell Proliferation     |    2                    2                                                |             
      Hyperplasia, Focal, Lymphoid         |       2                                      3     4              3      |             
      Necrosis                             |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  M  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Galactocele                          |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Cyst, Squamous                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Necrosis                             |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    1  1  1  4  1  1  1        1  1  1  1  1  1     1  1  1     1  1  1   |             
      Inflammation, Chronic Active         |                      1                       1                    2      |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                              1                    2  2   |             
      Thrombosis                           |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia     |                   3        4     1           1           3           2   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1     1                                2  2     2  1           1  1      |             
      Thrombosis                           |                               3        1                                 |             
      Olfactory Epithelium, Atrophy        |                         1              1                                 |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                               +  +                                       |             
      Cataract                             |                               4                                          |             
      Degeneration                         |                                  3                                       |             
      Retina, Atrophy                      |                               4                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 2| 9| 3| 3| 2| 3| 2| 3| 8| 2| 1| 8| 9| 3| 4| 2| 2| 2| 4| 8| 2| 2| 2|             
                                           | 6| 4| 9| 8| 0| 0| 5| 0| 7| 0| 4| 9| 2| 2| 8| 0| 7| 9| 7| 9| 0| 3| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2                                3                           |             
      Infarct                              |                                        2                                 |             
      Mineralization                       |                                           2                              |             
      Nephropathy                          | 4  2  3  3  3  2  4  3  2  3  2  2  2  3  4  3  2  2  2  3  2  2  4  4  3|             
      Pigmentation                         |                                        3                                 |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                       4                  |             
      Transitional Epithelium, Hyperplasia | 2                                         2                       1  1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |    3                                                                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |             X              X                                             |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |       X                                X                 X              X|      6     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X     X           X     X  X        X  X              X  X  X           X|     26     |
      Clear Cell Focus                     |       X           X  X  X  X        X  X  X           X  X  X     X     X|     23     |
      Degeneration, Cystic                 |                                     2                       1  2     2   |      6  1.7|
      Eosinophilic Focus                   |                                        X  X                              |      2     |
      Fatty Change                         |    4                                                                     |      3  2.7|
      Hepatodiaphragmatic Nodule           |    X                                               X                     |      4     |
      Inflammation, Focal, Granulomatous   | 2  1  2  2        2  1  2  2  1  1  2  1  2  1     1  2  1  1     2  1  1|     42  1.5|
      Inflammation, Focal, Histiocytic     | 2  2  1  1     1  1  2  2  2  2  2  2  2  2  2  1  2  2  1  1  2  2  2  1|     46  1.7|
      Mixed Cell Focus                     |                      X                                                   |      2     |
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1        1  1  1  1  1  2     2  1     1  1  2  1  1  1  1  3  1  2  2|     43  1.4|
      Centrilobular, Necrosis              |    1        1  3                             2  3              3         |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   6        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis                        |                            2                                             |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      1        2  1              2           2            |     12  1.9|
      Basophilic Focus                     |          X                 X                                             |      2     |
      Hyperplasia                          |                                     3                          2         |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Hyperplasia, Diffuse, Squamous       |                                                    2                     |      1  2.0|
      Hyperplasia, Squamous                |                   1                                                  2   |      3  2.0|
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Ulcer                                |    3                          4              2     1                     |      8  2.6|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                     +            |   3        |
      Inflammation, Chronic Active         |       2                                                     1            |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  1  2  2  2  2  2  2  2  2     2        1  2  2  1  3  2  2  2|     43  1.9|
      Necrosis                             |                                              2                           |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                 1        2  1  2  2  2  1     2     2  2  2  1         |     26  1.7|
      Hypertrophy                          |                                                 2  2                 2   |      6  2.0|
      Necrosis                             |                                              2                           |      1  2.0|
      Vacuolization Cytoplasmic            |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             4  2           3  2           3     2        3  1            |     24  2.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1                             4            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   1      |      1  1.0|
      Pars Distalis, Hyperplasia           |       1     3                 1  2     2        2     1     2  1         |     16  1.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 1     1     1     1  1  1  1              1  1  1        1  1  2  1      |     31  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                   4      |      3  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 3     1     2     3      |     10  2.0|
      Inflammation, Chronic Active         |                                     2     2              2           3  2|     12  2.1|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +     +                    +     +     +  +              +     +  +|  21        |
      Bronchial, Ectasia                   |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  +  +  M  +  +  M  M  M  M  M  +  M  +  +  M  +  M  +  M  M  +|  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |             2                                                            |      4  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Focal, Lymphoid         |       3                    3     3  2                       2            |      9  2.8|
      Necrosis                             |                                                 3                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Atrophy                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Galactocele                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                             +            |   1        |
      Cyst, Squamous                       |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                 2                        |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    | 1  1  1  1        1  1  1  1  1  1        1  1     1  1  1  1  1  1  1  1|     39  1.1|
      Inflammation, Chronic Active         |             1                                                            |      4  1.3|
      Inflammation, Suppurative            |    2                                                                     |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      3  1.7|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                            1              3              1              1|     10  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2        1                       2  1        2  1           2         |     15  1.5|
      Thrombosis                           |                                              3                 1         |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 4| 2| 2| 1| 8| 1| 2| 3| 2| 2| 3| 2| 3| 1| 2| 7| 2| 6| 2| 2| 3| 4| 3| 4| 3|            |
                                           | 3| 3| 9| 7| 6| 9| 9| 0| 9| 9| 0| 9| 0| 8| 9| 4| 9| 2| 9| 9| 0| 9| 0| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1.0%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Olfactory Epithelium, Atrophy        |                   1                                                      |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |    +           +                                                         |   2        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Inflammation, Suppurative            |    4                                                                     |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   3        |
      Cataract                             |                                                                   4      |      2  4.0|
      Degeneration                         |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                   4      |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                          3               |      3  2.7|
      Infarct                              |             2                                2                           |      3  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  4  4  3  2  1  3  4  3  2  4  4  3  2  3  3  4  2  3  2  2  2  2  3  3|     50  2.8|
      Pigmentation                         |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |             1                                                            |      2  2.5|
      Transitional Epithelium, Hyperplasia |                      1           1              1                        |      7  1.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  A  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  M  +  A  +  +  A  +  +  +  +  +  M  +  A  +  +  A  +  +|             
      Necrosis                             |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  M  +  A  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  A  +  A  +  +|             
      Necrosis                             |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Angiectasis                          |                                                                      1   |             
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X  X     X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change                         |                                           2     1                        |             
      Hepatodiaphragmatic Nodule           | X                                                           X  X         |             
      Inflammation, Focal, Granulomatous   | 1     1              1     1        1     1  1                           |             
      Inflammation, Focal, Histiocytic     | 3  3  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  2|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  1  1  2        1  2  2  1  2  1  1  1  1  1  1  1     2  1  3  1  2|             
      Centrilobular, Necrosis              |                                                                   2     2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                              +        +                 +|             
      Fat, Necrosis                        |                                              2        2                 2|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                         +           +                                    |             
      Pharyngeal, Hyperplasia              |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Atrophy                              | 1                    2                             1           1         |             
      Hyperplasia                          |                      2                                                  2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3        1     2  1           3  3  2  3                    1        1   |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Basal Cell              |                                     1                                    |             
      Hyperplasia, Diffuse, Squamous       |                                                                          |             
      Hyperplasia, Squamous                |    2           2                                                         |             
      Inflammation, Suppurative            |                                  2                                       |             
      Ulcer                                |       2     2        3              3                       3            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Cyst, Squamous                       |                               3                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                               1                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1           2     1  1  1     1  1           2     3|             
      Mineralization                       |          1                 1                                             |             
      Valve, Inflammation, Acute           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1  1           2                             3|             
      Hypertrophy                          |             1                             2                             1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +|             
      Hyperplasia                          |                            2                          2     2            |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                                  2                 1|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Pars Distalis, Hyperplasia           |                            1                                             |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  +|             
      C-Cell, Hyperplasia                  |                2  2                       1                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Granuloma Sperm                      |                         2                                                |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3                                                     3|             
      Hyperplasia                          |                2                                                         |             
      Inflammation, Chronic Active         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                      3                           |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2              3                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                                               +  +           +     +|             
      Mediastinal, Ectasia                 |                                                    2                     |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  +  M  +  M  M  M  +  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Fibrosis                             |                      2                    3                              |             
      Hyperplasia, Focal, Lymphoid         |                                                             2           2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Mineralization                       |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  1     1  1              1  1  1  1  1  1        1     1  1        1|             
      Inflammation, Chronic Active         |                                           1                              |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                 2                        |             
      Alveolar Epithelium, Hyperplasia     |       1     1                                                            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |    1           2        3                                               1|             
      Thrombosis                           |       3                                3           3  4                  |             
      Olfactory Epithelium, Atrophy        | 1        1  1  1  1  1     1  1  1  1  1     1  1  1        1  1     1   |             
      Olfactory Epithelium, Degeneration   |    3                                                              3     3|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |             1                                                            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                   2     2|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4     4  4  3  4  3|             
      Transitional Epithelium, Hyperplasia |       1  1     1           1                                   1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 6| 5| 5| 6| 6| 4| 6|             
                             DAY ON TEST   | 8| 9| 8| 4| 1| 1| 1| 2| 9| 6| 1| 2| 1| 1| 9| 9| 0| 8| 1| 3| 6| 8| 4| 4| 5|             
                                           | 4| 8| 6| 5| 9| 4| 0| 9| 6| 4| 3| 5| 4| 0| 0| 8| 2| 4| 3| 2| 4| 2| 0| 9| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    4.0%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  43        |
      Ulcer                                |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  A  +  A  A  +  +  +  +  +  +  A  +  +  +  +  A|  35        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  39        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A|  36        |
      Necrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                       2                  |      2  1.5|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X|     45     |
      Clear Cell Focus                     |                X  X                                                      |      2     |
      Degeneration, Cystic                 |                                                       2              2   |      2  2.0|
      Fatty Change                         |                                  2                          2           1|      5  1.6|
      Hepatodiaphragmatic Nodule           |                                     X                             X      |      5     |
      Inflammation, Focal, Granulomatous   |    2  2     2  1  2  1  2  2  2  2  3  1  1  1  1  1        1  1     1  1|     27  1.4|
      Inflammation, Focal, Histiocytic     | 3  3  3  3  2  3  2  3  3  3  3  3  3  3  3  2  3  2  2  3  3  3  3  3  3|     48  2.9|
      Mixed Cell Focus                     |                                  X                    X                  |      2     |
      Bile Duct, Hyperplasia               | 2  1  1  1  2  1  1  1  1        1  1  1  1  1  2  1     1  2  1  3  2  1|     44  1.4|
      Centrilobular, Necrosis              |                                                                   4      |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   4        |
      Fat, Necrosis                        |                                              3                           |      4  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Oral Mucosa                             |                                                                          |   2        |
      Pharyngeal, Hyperplasia              |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 2     2           2                       1     1                        |      9  1.4|
      Hyperplasia                          |    2  2                                            2                     |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 1  2        1              2  2        1     1  1  2  2        1     3   |     22  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                     1                                    |      1  1.0|
      Hyperplasia, Basal Cell              |                                                       2                  |      2  1.5|
      Hyperplasia, Diffuse, Squamous       |          1                                                               |      1  1.0|
      Hyperplasia, Squamous                |             1                                                  1     1   |      5  1.4|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |          2     4           1                 2        2                  |     10  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst, Squamous                       |                                                                          |      1  3.0|
      Mineralization                       |             2                    3                                       |      2  2.5|
      Necrosis                             |             2  1                                      3                  |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                  +                    +                  |   2        |
      Aorta, Mineralization                |                                  4                                       |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 1        1  2  1  2  2  2  2  1     2        1  1     1                  |     22  1.5|
      Mineralization                       |          1  2                    2                       1              1|      7  1.3|
      Valve, Inflammation, Acute           |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |          2                 1                 1                          3|      8  1.8|
      Hypertrophy                          |                      2                          2                        |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                 1                        |      4  1.8|
      Necrosis                             |                                                                   4      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1           1                                                |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       1                    3  2                 2           1            |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  |                                                                          |      3  1.7|
      Follicular Cell, Hyperplasia         |                      1                                      3            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               2                                1     1   |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |             2                                                            |      3  2.3|
      Interstitial Cell, Hyperplasia       |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +                                   +        +  +      |   9        |
      Mediastinal, Ectasia                 |                   4                                                      |      2  3.0|
      Mediastinal, Hemorrhage              |                                                       1                  |      1  1.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  M  +  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  +  +  M  M  M|  11        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  44        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Subcutaneous Tissue, Hemorrhage      |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   2        |
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Histiocyte    | 1     1  1        1     1  1  1     1  1  1  1  1  1  1  1  1  1     1  1|     34  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                  3                                       |      1  3.0|
      Thrombosis                           |                            1     2                                       |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                2                                3  1                     |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                 1                    2   |      6  1.7|
      Thrombosis                           |                                     2           2           2     3     4|      9  2.9|
      Olfactory Epithelium, Atrophy        | 1     1  1           1     1     1  1  1  1  1  2  1  1  1  1  1     1   |     34  1.0|
      Olfactory Epithelium, Degeneration   |       1        3  2              2                                       |      7  2.4|
      Olfactory Epithelium, Metaplasia     |                                                 2                    2   |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 88031-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 02/04/02    
Route: DOSED WATER                                                                                                Time: 10:30:16    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 5| 5| 4| 6| 4| 6| 5| 5| 6| 3| 5| 5| 5| 6| 6| 6| 6| 4| 5| 5| 4| 5| 4|            |
                             DAY ON TEST   | 2| 2| 6| 8| 3| 2| 3| 3| 6| 7| 4| 9| 5| 4| 0| 2| 1| 2| 7| 8| 7| 8| 0| 6| 8|            |
                                           | 9| 7| 5| 9| 1| 7| 8| 1| 4| 8| 7| 8| 4| 3| 7| 7| 7| 4| 3| 4| 4| 4| 8| 1| 3|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    4.0%                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Cataract                             |                2                                                         |      1  2.0|
      Retina, Atrophy                      |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hydronephrosis                       |                                  2                                       |      1  2.0|
      Infarct                              |                                                                          |      2  2.0|
      Mineralization                       |             3                    3                                       |      2  3.0|
      Nephropathy                          | 4  4  4  4  4  4  2  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4|     48  3.9|
      Transitional Epithelium, Hyperplasia |                1     1                       1  1                        |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                  3                                       |      1  3.0|
      Necrosis                             |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
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