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TDMS Study 88031-05 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 02/04/02       
EXPERIMENT: 88031 TEST: 05                                                                                     TIME: 13:39:24       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: MISSING                                                                                           CAS: 25265-71-8      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   DIPROPYLENE GLYCOL                                                                             
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Adrenal Medulla                        Hyperplasia                                                                                  
Eye: Retina                            Atrophy                                                                                      
Heart                                  Cardiomyopathy                                                                               
                                       Mineralization                                                                               
Heart: Atrium                          Thrombosis                                                                                   
Intestine Large, Rectum                Parasite Metazoan                                                                            
Kidney                                 Nephropathy                                                                                  
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Fatty Change                                                                                 
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Inflammation Focal Granulomatous                                                             
                                       Inflammation Focal Histiocytic                                                               
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Necrosis                                                                                     
Lung                                   Infiltration Cellular Histiocyte                                                             
                                       Inflammation Chronic                                                                         
                                       Thrombosis                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
                                       Thrombosis                                                                                   
Nose: Olfactory Epithelium             Atrophy                                                                                      
                                       Degeneration                                                                                 
                                       Metaplasia                                                                                   
Pancreas                               Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Parathyroid Gland                      Hyperplasia                                                                                  
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Preputial Gland                        Cyst                                                                                         
Prostate                               Hyperplasia                                                                                  
                                       Inflammation Chronic                                                                         
Salivary Glands                        Inflammation                                                                                 
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia Focal Lymphoid                                                                   
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Hyperplasia Basal Cell                                                                       
                                       Ulcer                                                                                        
Stomach, Glandular                     Necrosis                                                                                     
Testes                                 Atrophy                                                                                      
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                     DIPROPYLENE GLYCOL                                  DATE: 02/04/02       
EXPERIMENT: 88031 TEST: 05                                                                                     TIME: 13:39:24       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED WATER                                             NTP C#: C88031       
PATHOLOGIST: MISSING                                                                                           CAS: 25265-71-8      
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
Adrenal Medulla                        Necrosis                                                                                     
Heart                                  Cardiomyopathy                                                                               
Liver                                  Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Inflammation Focal Histiocytic                                                               
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose: Olfactory Epithelium             Degeneration                                                                                 
Nose: Respiratory Epithelium           Accumulation, Hyaline Droplet                                                                
Parathyroid Gland                      Hyperplasia                                                                                  
Skin                                   Inflammation Chronic                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/49 (0%)    0/50 (0%)    0/48 (0%)   |5/49 (10%)   2/47 (4%)    0/47 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/37.58      0/41.97      0/42.10      0/24.30     |5/42.75      2/41.30      0/44.49      0/42.03      | 
|POLY-3 PERCENT (g) |     2.7%         0.0%         0.0%         0.0%        |11.7%        4.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |5/30 (17%)   1/31 (3%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |729 (T)      717          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.994N     P=0.468N     P=0.468N     P=1.000N    |P=0.039N*    P=0.200N     P=0.017N*    P=0.029N*    | 
|POLY 3             |     P=0.532N     P=0.478N     P=0.477N     P=0.583N    |P=0.041N*    P=0.229N     P=0.027N*    P=0.031N*    | 
|POLY 1.5           |     P=0.552N     P=0.483N     P=0.480N     P=0.539N    |P=0.041N*    P=0.230N     P=0.029N*    P=0.032N*    | 
|POLY 6             |     P=0.433N     P=0.472N     P=0.475N     P=0.651N    |P=0.042N*    P=0.229N     P=0.025N*    P=0.031N*    | 
|LOGISTIC REGRESSION|     P=0.994N     (e)          (e)          (e)         |P=0.039N*    P=0.218N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.548N     P=0.490N     P=0.485N     P=0.495N    |P=0.043N*    P=0.235N     P=0.031N*    P=0.031N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/47 (32%)  22/49 (45%)  26/50 (52%)  8/48 (17%)  |18/49 (37%)  24/47 (51%)  25/47 (53%)  13/47 (28%)  | 
|POLY-3 RATE (b)    |     15/38.16     22/44.73     26/44.77     8/27.72     |18/43.83     24/42.21     25/44.82     13/42.74     | 
|POLY-3 PERCENT (g) |     39.3%        49.2%        58.1%        28.9%       |41.1%        56.9%        55.8%        30.4%        | 
|TERMINAL (d)       |     13/23 (57%)  15/27 (56%)  17/27 (63%)  0/0 (0%)    |15/30 (50%)  21/31 (68%)  24/38 (63%)  10/31 (32%)  | 
|FIRST INCIDENCE    |     565          417          543          483         |542          542          638          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.238      P=0.074      P<0.001 **  |P=0.025N*    P=0.169      P=0.391      P=0.169N     | 
|POLY 3             |     P=0.149N     P=0.244      P=0.061      P=0.265N    |P=0.024N*    P=0.100      P=0.116      P=0.207N     | 
|POLY 1.5           |     P=0.032N*    P=0.198      P=0.050      P=0.137N    |P=0.026N*    P=0.108      P=0.103      P=0.210N     | 
|POLY 6             |     P=0.526      P=0.316      P=0.077      P=0.582N    |P=0.024N*    P=0.089      P=0.131      P=0.209N     | 
|LOGISTIC REGRESSION|     P=0.295N     P=0.191      P=0.049 *    P=0.410     |P=0.028N*    P=0.105      P=0.163      P=0.205N     | 
|COCH-ARM / FISHERS |     P=0.004N**   P=0.136      P=0.036 *    P=0.067N    |P=0.037N*    P=0.113      P=0.078      P=0.232N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/47 (11%)   4/49 (8%)    6/50 (12%)   5/48 (10%)  |11/49 (22%)  14/47 (30%)  12/47 (26%)  9/47 (19%)   | 
|POLY-3 RATE (b)    |     5/38.52      4/42.00      6/43.30      5/25.86     |11/43.26     14/41.45     12/44.74     9/43.22      | 
|POLY-3 PERCENT (g) |     13.0%        9.5%         13.9%        19.3%       |25.4%        33.8%        26.8%        20.8%        | 
|TERMINAL (d)       |     2/23 (9%)    3/27 (11%)   3/27 (11%)   0/0 (0%)    |8/30 (27%)   12/31 (39%)  10/38 (26%)  5/31 (16%)   | 
|FIRST INCIDENCE    |     565          721          562          617         |659          683          667          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.412N     P=0.558      P<0.001 **  |P=0.231N     P=0.338      P=0.468N     P=0.396N     | 
|POLY 3             |     P=0.239      P=0.445N     P=0.582      P=0.371     |P=0.201N     P=0.272      P=0.537      P=0.400N     | 
|POLY 1.5           |     P=0.367      P=0.454N     P=0.571      P=0.509     |P=0.211N     P=0.279      P=0.510      P=0.411N     | 
|POLY 6             |     P=0.114      P=0.436N     P=0.591      P=0.184     |P=0.196N     P=0.259      P=0.565      P=0.396N     | 
|LOGISTIC REGRESSION|     P=0.247      P=0.435N     P=0.546      P=0.277     |P=0.223N     P=0.273      P=0.581      P=0.422N     | 
|COCH-ARM / FISHERS |     P=0.542      P=0.473N     P=0.544      P=0.616N    |P=0.237N     P=0.279      P=0.454      P=0.442N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    4/49 (8%)    1/50 (2%)    0/48 (0%)   |1/49 (2%)    2/47 (4%)    0/47 (0%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     1/37.86      4/42.37      1/42.31      0/24.30     |1/42.83      2/41.78      0/44.49      2/42.39      | 
|POLY-3 PERCENT (g) |     2.6%         9.4%         2.4%         0.0%        |2.3%         4.8%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     653          649          674          ---         |709          634          ---          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.670N     P=0.234      P=0.758      P=0.912N    |P=0.441      P=0.501      P=0.462N     P=0.491      | 
|POLY 3             |     P=0.210N     P=0.214      P=0.736N     P=0.584N    |P=0.447      P=0.491      P=0.492N     P=0.496      | 
|POLY 1.5           |     P=0.169N     P=0.206      P=0.739N     P=0.540N    |P=0.447      P=0.490      P=0.498N     P=0.494      | 
|POLY 6             |     P=0.258N     P=0.225      P=0.734N     P=0.653N    |P=0.445      P=0.493      P=0.487N     P=0.498      | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.206      P=0.754N     P=0.601N    |P=0.426      P=0.481      P=0.498N     P=0.484      | 
|COCH-ARM / FISHERS |     P=0.127N     P=0.194      P=0.737N     P=0.495N    |P=0.443      P=0.484      P=0.510N     P=0.484      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/47 (49%)  23/49 (47%)  24/50 (48%)  4/47 (9%)   |12/49 (24%)  8/47 (17%)   10/46 (22%)  7/47 (15%)   | 
|POLY-3 RATE (b)    |     23/40.09     23/43.83     24/44.51     4/25.78     |12/43.24     8/42.57      10/43.89     7/42.55      | 
|POLY-3 PERCENT (g) |     57.4%        52.5%        53.9%        15.5%       |27.8%        18.8%        22.8%        16.5%        | 
|TERMINAL (d)       |     13/23 (57%)  15/27 (56%)  16/27 (59%)  0/0 (0%)    |10/30 (33%)  3/31 (10%)   8/38 (21%)   4/31 (13%)   | 
|FIRST INCIDENCE    |     565          456          564          564         |626          542          717          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.242      P=0.322N     P=0.420N     P=0.238     |P=0.224N     P=0.220N     P=0.206N     P=0.149N     | 
|POLY 3             |     P<0.001N**   P=0.406N     P=0.459N     P<0.001N**  |P=0.218N     P=0.233N     P=0.387N     P=0.157N     | 
|POLY 1.5           |     P<0.001N**   P=0.433N     P=0.478N     P<0.001N**  |P=0.217N     P=0.241N     P=0.416N     P=0.162N     | 
|POLY 6             |     P=0.042N*    P=0.385N     P=0.462N     P=0.018N*   |P=0.223N     P=0.225N     P=0.357N     P=0.156N     | 
|LOGISTIC REGRESSION|     P=0.005N**   P=0.377N     P=0.443N     P=0.012N*   |P=0.213N     P=0.253N     P=0.326N     P=0.161N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.503N     P=0.544N     P<0.001N**  |P=0.224N     P=0.259N     P=0.471N     P=0.178N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/49 (0%)    0/50 (0%)    1/47 (2%)   |0/49 (0%)    0/47 (0%)    0/46 (0%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     1/38.12      0/41.97      0/42.10      1/24.73     |0/42.75      0/41.25      0/43.82      2/42.16      | 
|POLY-3 PERCENT (g) |     2.6%         0.0%         0.0%         4.0%        |0.0%         0.0%         0.0%         4.7%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     564          ---          ---          408         |---          ---          ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.513N     P=0.496N     P=0.729     |P=0.039 *    (e)          (e)          P=0.234      | 
|POLY 3             |     P=0.432      P=0.481N     P=0.480N     P=0.656     |P=0.041 *    (e)          (e)          P=0.234      | 
|POLY 1.5           |     P=0.468      P=0.484N     P=0.482N     P=0.712     |P=0.041 *    (e)          (e)          P=0.233      | 
|POLY 6             |     P=0.395      P=0.476N     P=0.480N     P=0.549     |P=0.041 *    (e)          (e)          P=0.234      | 
|LOGISTIC REGRESSION|     P=0.625      P=0.563N     P=0.553N     P=0.722N    |P=0.041 *    (e)          (e)          P=0.233      | 
|COCH-ARM / FISHERS |     P=0.517      P=0.490N     P=0.485N     P=0.753N    |P=0.041 *    (e)          (e)          P=0.237      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteopetrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.90      0/42.41      0/42.10      0/25.17     |1/43.29      3/43.04      1/45.88      1/43.95      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         7.0%         2.2%         2.3%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    3/31 (10%)   1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |697          729 (T)      729 (T)      652          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.442N     P=0.308      P=0.728N     P=0.748      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.435N     P=0.303      P=0.748N     P=0.757N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.433N     P=0.305      P=0.752N     P=0.757N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.440N     P=0.299      P=0.742N     P=0.760N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.435N     P=0.301      P=0.749N     P=0.759      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.435N     P=0.309      P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/48 (10%)   2/44 (5%)    3/48 (6%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |                                                        |5/42.38      2/38.47      3/44.35      3/42.15      | 
|POLY-3 PERCENT (g) |                                                        |11.8%        5.2%         6.8%         7.1%         | 
|TERMINAL (d)       |                                                        |3/29 (10%)   2/30 (7%)    2/37 (5%)    3/30 (10%)   | 
|FIRST INCIDENCE    |                                                        |543          729 (T)      667          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.500N     P=0.210N     P=0.267N     P=0.341N     | 
|POLY 3             |                                                        |P=0.479N     P=0.256N     P=0.331N     P=0.359N     | 
|POLY 1.5           |                                                        |P=0.474N     P=0.253N     P=0.340N     P=0.353N     | 
|POLY 6             |                                                        |P=0.490N     P=0.261N     P=0.321N     P=0.371N     | 
|LOGISTIC REGRESSION|                                                        |P=0.471N     P=0.251N     P=0.366N     P=0.352N     | 
|COCH-ARM / FISHERS |                                                        |P=0.475N     P=0.255N     P=0.357N     P=0.357N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/48 (4%)    0/44 (0%)    0/48 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/41.55      0/38.47      0/44.12      1/42.15      | 
|POLY-3 PERCENT (g) |                                                        |4.8%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |                                                        |1/29 (3%)    0/30 (0%)    0/37 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |                                                        |697          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.695      P=0.245N     P=0.208N     P=0.505N     | 
|POLY 3             |                                                        |P=0.706      P=0.254N     P=0.224N     P=0.495N     | 
|POLY 1.5           |                                                        |P=0.707      P=0.254N     P=0.229N     P=0.494N     | 
|POLY 6             |                                                        |P=0.702      P=0.254N     P=0.219N     P=0.499N     | 
|LOGISTIC REGRESSION|                                                        |P=0.707      P=0.253N     P=0.222N     P=0.499N     | 
|COCH-ARM / FISHERS |                                                        |P=0.706N     P=0.269N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   1/2 (50%)    2/3 (67%)    1/1 (100%)  |2/2 (100%)   0/1 (0%)     2/2 (100%)   1/3 (33%)    | 
|POLY-3 RATE (b)    |     2/2.00       1/1.45       2/3.00       1/1.00      |2/2.00       0/0.95       2/2.00       1/3.00       | 
|POLY-3 PERCENT (g) |     100.0%       69.0%        66.7%        100.0%      |100.0%       0.0%         100.0%       33.3%        | 
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   1/2 (50%)    0/0 (0%)    |1/1 (100%)   0/0 (0%)     1/1 (100%)   0/2 (0%)     | 
|FIRST INCIDENCE    |     582          729 (T)      584          627         |624          ---          598          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.344      P=0.495N     P=0.564N     (e)         |P=0.397N     P=0.521N     (e)          P=0.424N     | 
|POLY 3             |     P=0.785      P=0.819N     P=0.577N     (e)         |P=0.229N     P=1.000N     (e)          P=0.281N     | 
|POLY 1.5           |     P=0.744      P=0.644N     P=0.577N     (e)         |P=0.236N     P=1.000N     (e)          P=0.281N     | 
|POLY 6             |     P=0.824      P=0.998N     P=0.577N     (e)         |P=0.215N     P=1.000N     (e)          P=0.281N     | 
|LOGISTIC REGRESSION|     P=0.708      P=0.495N     (e)          (e)         |P=0.364N     P=0.424N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.719      P=0.500N     P=0.600N     (e)         |P=0.279N     P=0.333N     (e)          P=0.300N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     1/3 (33%)    0/1 (0%)    |0/2 (0%)     0/1 (0%)     0/2 (0%)     2/3 (67%)    | 
|POLY-3 RATE (b)    |     0/1.51       0/1.45       1/2.51       0/0.64      |0/1.63       0/0.95       0/1.55       2/2.82       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         39.8%        0.0%        |0.0%         0.0%         0.0%         71.0%        | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     1/2 (50%)    0/0 (0%)    |0/1 (0%)     0/0 (0%)     0/1 (0%)     2/2 (100%)   | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.991      (e)          P=0.638      (e)         |P=0.166      (e)          (e)          P=0.362      | 
|POLY 3             |     P=0.815      (e)          P=0.600      (e)         |P=0.078      (e)          (e)          P=0.314      | 
|POLY 1.5           |     P=0.835      (e)          P=0.589      (e)         |P=0.076      (e)          (e)          P=0.298      | 
|POLY 6             |     P=0.731      (e)          P=0.616      (e)         |P=0.080      (e)          (e)          P=0.341      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.638      (e)         |(e)          (e)          (e)          P=0.362      | 
|COCH-ARM / FISHERS |     P=0.894      (e)          P=0.600      (e)         |P=0.086      (e)          (e)          P=0.300      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/2 (50%)    1/2 (50%)    2/3 (67%)    1/1 (100%)  |2/2 (100%)   0/1 (0%)     1/2 (50%)    2/3 (67%)    | 
|POLY-3 RATE (b)    |     1/1.51       1/1.45       2/3.00       1/1.00      |2/2.00       0/0.95       1/1.55       2/3.00       | 
|POLY-3 PERCENT (g) |     66.3%        69.0%        66.7%        100.0%      |100.0%       0.0%         64.4%        66.7%        | 
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   1/2 (50%)    0/0 (0%)    |1/1 (100%)   0/0 (0%)     1/1 (100%)   1/2 (50%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      584          627         |624          ---          729 (T)      681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084      P=1.000N     P=0.689      P=0.011 *   |P=0.657N     P=0.521N     P=0.495N     P=0.580N     | 
|POLY 3             |     P=0.635      P=0.852      P=0.795      P=0.799     |P=0.689N     P=1.000      P=0.727N     P=0.577N     | 
|POLY 1.5           |     P=0.566      P=0.800      P=0.741      P=0.698     |P=0.706N     P=1.000      P=0.602N     P=0.577N     | 
|POLY 6             |     P=0.727      P=0.964      P=0.751N     P=0.971     |P=0.658N     P=1.000N     P=0.953N     P=0.577N     | 
|LOGISTIC REGRESSION|     P=0.457      P=1.000N     P=0.740      (e)         |P=0.713N     P=0.424N     P=0.495N     (e)          | 
|COCH-ARM / FISHERS |     P=0.485      P=0.833N     P=0.700      P=0.667     |P=0.721      P=0.333N     P=0.500N     P=0.600N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  42/50 (84%)  43/50 (86%)  22/49 (45%) |33/50 (66%)  42/50 (84%)  32/50 (64%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     41/46.44     42/47.54     43/48.23     22/34.56    |33/44.97     42/46.83     32/47.48     26/44.64     | 
|POLY-3 PERCENT (g) |     88.3%        88.4%        89.2%        63.7%       |73.4%        89.7%        67.4%        58.3%        | 
|TERMINAL (d)       |     22/23 (96%)  25/27 (93%)  25/27 (93%)  0/0 (0%)    |24/30 (80%)  31/31 (100%) 26/38 (68%)  21/31 (68%)  | 
|FIRST INCIDENCE    |     261          417          340          431         |543          417          597          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.273N     P=0.380N     P<0.001 **  |P=0.013N*    P=0.078      P=0.105N     P=0.097N     | 
|POLY 3             |     P<0.001N**   P=0.635      P=0.583      P=0.002N**  |P=0.003N**   P=0.026 *    P=0.339N     P=0.087N     | 
|POLY 1.5           |     P<0.001N**   P=0.596      P=0.518      P<0.001N**  |P=0.003N**   P=0.030 *    P=0.400N     P=0.087N     | 
|POLY 6             |     P=0.032N*    P=0.658N     P=0.649      P=0.047N*   |P=0.005N**   P=0.019 *    P=0.278N     P=0.101N     | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.598N     P=0.505      P=0.010N*   |P=0.003N**   P=0.019 *    P=0.306N     P=0.086N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500      P=0.393      P<0.001N**  |P=0.006N**   P=0.032 *    P=0.500N     P=0.111N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    7/49 (14%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/39.90      0/42.41      0/42.10      7/28.95     |0/43.16      0/43.04      0/45.88      0/43.66      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         24.2%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          398         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.002 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.003 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   (e)          (e)          P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          (e)          P=0.024 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          (e)          P=0.006 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   2/50 (4%)    0/49 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/39.90      5/43.41      2/42.77      0/24.59     |0/43.16      2/43.22      0/45.88      1/44.11      | 
|POLY-3 PERCENT (g) |     0.0%         11.5%        4.7%         0.0%        |0.0%         4.6%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          614          584          ---         |---          680          ---          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.577N     P=0.056      P=0.263      (e)         |P=0.631      P=0.238      (e)          P=0.505      | 
|POLY 3             |     P=0.276N     P=0.038 *    P=0.253      (e)         |P=0.637      P=0.237      (e)          P=0.504      | 
|POLY 1.5           |     P=0.206N     P=0.035 *    P=0.247      (e)         |P=0.638      P=0.238      (e)          P=0.504      | 
|POLY 6             |     P=0.388N     P=0.043 *    P=0.259      (e)         |P=0.635      P=0.237      (e)          P=0.504      | 
|LOGISTIC REGRESSION|     P=0.151N     P=0.033 *    P=0.213      (e)         |P=0.625      P=0.237      (e)          P=0.439      | 
|COCH-ARM / FISHERS |     P=0.146N     P=0.028 *    P=0.247      (e)         |P=0.634      P=0.247      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/41 (10%)   1/49 (2%)    3/48 (6%)    0/43 (0%)   |4/48 (8%)    4/47 (9%)    1/48 (2%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     4/34.61      1/41.97      3/41.97      0/21.83     |4/41.63      4/40.49      1/44.45      2/41.10      | 
|POLY-3 PERCENT (g) |     11.6%        2.4%         7.2%         0.0%        |9.6%         9.9%         2.3%         4.9%         | 
|TERMINAL (d)       |     3/23 (13%)   1/27 (4%)    1/27 (4%)    0/0 (0%)    |3/30 (10%)   3/30 (10%)   1/38 (3%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     568          729 (T)      586          ---         |626          717          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489N     P=0.144N     P=0.429N     P=0.579N    |P=0.280N     P=0.638N     P=0.126N     P=0.325N     | 
|POLY 3             |     P=0.218N     P=0.123N     P=0.395N     P=0.143N    |P=0.293N     P=0.629      P=0.159N     P=0.342N     | 
|POLY 1.5           |     P=0.158N     P=0.124N     P=0.399N     P=0.089N    |P=0.293N     P=0.632      P=0.166N     P=0.345N     | 
|POLY 6             |     P=0.308N     P=0.121N     P=0.394N     P=0.276N    |P=0.296N     P=0.625      P=0.151N     P=0.343N     | 
|LOGISTIC REGRESSION|     P=0.146N     P=0.123N     P=0.417N     P=0.188N    |P=0.283N     P=0.633      P=0.161N     P=0.338N     | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.130N     P=0.411N     P=0.052N    |P=0.299N     P=0.631      P=0.181N     P=0.359N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/40 (15%)   3/50 (6%)    6/48 (13%)   0/44 (0%)   |7/48 (15%)   5/47 (11%)   13/49 (27%)  3/46 (7%)    | 
|POLY-3 RATE (b)    |     6/33.76      3/42.41      6/41.49      0/22.24     |7/41.76      5/40.78      13/45.12     3/41.10      | 
|POLY-3 PERCENT (g) |     17.8%        7.1%         14.5%        0.0%        |16.8%        12.3%        28.8%        7.3%         | 
|TERMINAL (d)       |     5/22 (23%)   3/27 (11%)   4/27 (15%)   0/0 (0%)    |5/30 (17%)   5/31 (16%)   13/38 (34%)  3/31 (10%)   | 
|FIRST INCIDENCE    |     565          729 (T)      712          ---         |626          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.676N     P=0.158N     P=0.480N     P=0.576N    |P=0.120N     P=0.366N     P=0.235      P=0.153N     | 
|POLY 3             |     P=0.123N     P=0.139N     P=0.471N     P=0.052N    |P=0.118N     P=0.395N     P=0.139      P=0.162N     | 
|POLY 1.5           |     P=0.063N     P=0.139N     P=0.472N     P=0.024N*   |P=0.122N     P=0.392N     P=0.130      P=0.164N     | 
|POLY 6             |     P=0.268N     P=0.137N     P=0.476N     P=0.160N    |P=0.119N     P=0.398N     P=0.150      P=0.163N     | 
|LOGISTIC REGRESSION|     P=0.352N     P=0.132N     P=0.462N     P=0.163N    |P=0.124N     P=0.382N     P=0.174      P=0.156N     | 
|COCH-ARM / FISHERS |     P=0.027N*    P=0.145N     P=0.486N     P=0.009N**  |P=0.140N     P=0.395N     P=0.114      P=0.176N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/44 (0%)    0/48 (0%)    2/50 (4%)    0/47 (0%)   |0/47 (0%)    0/48 (0%)    0/48 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/36.11      0/41.54      2/42.10      0/23.65     |0/41.03      0/41.44      0/45.05      0/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    2/27 (7%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.736      (e)          P=0.274      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.628      (e)          P=0.272      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.728N     (e)          P=0.272      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.352      (e)          P=0.270      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.274      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.649N     (e)          P=0.280      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    3/50 (6%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    1/49 (2%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/37.91      0/42.41      3/42.10      0/24.20     |0/42.42      0/42.07      1/45.12      0/42.03      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         7.1%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    3/27 (11%)   0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.399      (e)          P=0.149      (e)         |P=0.779N     (e)          P=0.547      (e)          | 
|POLY 3             |     P=0.568      (e)          P=0.138      (e)         |P=0.773N     (e)          P=0.512      (e)          | 
|POLY 1.5           |     P=0.690N     (e)          P=0.136      (e)         |P=0.775N     (e)          P=0.508      (e)          | 
|POLY 6             |     P=0.263      (e)          P=0.138      (e)         |P=0.773N     (e)          P=0.518      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.149      (e)         |(e)          (e)          P=0.547      (e)          | 
|COCH-ARM / FISHERS |     P=0.585N     (e)          P=0.133      (e)         |P=0.780N     (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/47 (6%)    6/50 (12%)   3/50 (6%)    2/48 (4%)   |3/49 (6%)    2/49 (4%)    1/49 (2%)    4/47 (9%)    | 
|POLY-3 RATE (b)    |     3/38.74      6/43.58      3/42.98      2/24.80     |3/42.44      2/42.86      1/45.55      4/42.76      | 
|POLY-3 PERCENT (g) |     7.7%         13.8%        7.0%         8.1%        |7.1%         4.7%         2.2%         9.4%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |2/30 (7%)    1/31 (3%)    0/38 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     511          614          586          640         |724          435          604          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      P=0.340      P=0.613N     P=0.123     |P=0.275      P=0.491N     P=0.245N     P=0.499      | 
|POLY 3             |     P=0.442N     P=0.302      P=0.614N     P=0.659     |P=0.271      P=0.496N     P=0.280N     P=0.504      | 
|POLY 1.5           |     P=0.341N     P=0.292      P=0.619N     P=0.594N    |P=0.267      P=0.495N     P=0.290N     P=0.496      | 
|POLY 6             |     P=0.558N     P=0.319      P=0.611N     P=0.489     |P=0.274      P=0.498N     P=0.269N     P=0.511      | 
|LOGISTIC REGRESSION|     P=0.248N     P=0.264      P=0.665      P=0.645N    |P=0.229      P=0.502N     P=0.301N     P=0.487      | 
|COCH-ARM / FISHERS |     P=0.227N     P=0.275      P=0.631N     P=0.490N    |P=0.258      P=0.500N     P=0.309N     P=0.476      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    2/50 (4%)    1/50 (2%)    2/48 (4%)   |1/49 (2%)    0/49 (0%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/37.91      2/42.97      1/42.55      2/25.83     |1/42.42      0/42.07      0/45.12      0/42.03      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.4%         7.7%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |1/30 (3%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          558          598          398         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      P=0.260      P=0.519      P=0.249     |P=0.550N     P=0.493N     P=0.453N     P=0.493N     | 
|POLY 3             |     P=0.211      P=0.266      P=0.523      P=0.164     |P=0.557N     P=0.502N     P=0.488N     P=0.502N     | 
|POLY 1.5           |     P=0.267      P=0.261      P=0.520      P=0.200     |P=0.556N     P=0.500N     P=0.492N     P=0.503N     | 
|POLY 6             |     P=0.145      P=0.272      P=0.526      P=0.116     |P=0.558N     P=0.504N     P=0.482N     P=0.502N     | 
|LOGISTIC REGRESSION|     P=0.561      P=0.233      P=0.472      P=0.160     |P=0.550N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.337      P=0.263      P=0.515      P=0.253     |P=0.554N     P=0.500N     P=0.500N     P=0.510N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/47 (87%)  47/50 (94%)  50/50 (100%) 48/48 (100%)|43/49 (88%)  45/49 (92%)  47/49 (96%)  46/47 (98%)  | 
|POLY-3 RATE (b)    |     41/44.55     47/48.68     50/50.00     48/48.00    |43/47.12     45/47.28     47/47.62     46/47.00     | 
|POLY-3 PERCENT (g) |     92.0%        96.6%        100.0%       100.0%      |91.3%        95.2%        98.7%        97.9%        | 
|TERMINAL (d)       |     23/23 (100%) 27/27 (100%) 27/27 (100%) 0/0 (0%)    |30/30 (100%) 31/31 (100%) 38/38 (100%) 30/31 (97%)  | 
|FIRST INCIDENCE    |     261          417          340          398         |247          425          597          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.561N     P=0.352      P<0.001 **  |P=0.345      P=0.483      P=0.200N     P=0.412      | 
|POLY 3             |     P=0.047 *    P=0.278      P=0.038 *    P=0.042 *   |P=0.168      P=0.350      P=0.090      P=0.151      | 
|POLY 1.5           |     P=0.030 *    P=0.257      P=0.022 *    P=0.025 *   |P=0.109      P=0.358      P=0.091      P=0.104      | 
|POLY 6             |     P=0.092      P=0.310      P=0.075      P=0.081     |P=0.280      P=0.339      P=0.102      P=0.229      | 
|LOGISTIC REGRESSION|     P=0.006 **   P=0.302      P=0.022 *    P=0.005 **  |P=0.123      P=0.385      P=0.210      P=0.089      | 
|COCH-ARM / FISHERS |     P=0.020 *    P=0.213      P=0.011 *    P=0.012 *   |P=0.068      P=0.370      P=0.134      P=0.062      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    2/50 (4%)    1/50 (2%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/38.11      2/43.03      1/42.29      0/24.20     |0/42.42      0/42.07      0/45.12      0/42.03      | 
|POLY-3 PERCENT (g) |     2.6%         4.7%         2.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     676          564          682          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602N     P=0.544      P=0.746N     P=0.970N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.340N     P=0.542      P=0.738N     P=0.586N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.294N     P=0.535      P=0.740N     P=0.541N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.388N     P=0.551      P=0.737N     P=0.655N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.233N     P=0.504      P=0.747N     P=0.719N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.239N     P=0.523      P=0.737N     P=0.495N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    2/50 (4%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    0/49 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/37.91      0/42.41      2/42.95      0/24.20     |0/42.42      0/42.07      0/45.12      0/42.03      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          586          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.766      (e)          P=0.253      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.629      (e)          P=0.265      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.730N     (e)          P=0.261      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.351      (e)          P=0.270      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.570N     (e)          P=0.207      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.655N     (e)          P=0.263      (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    3/50 (6%)    7/50 (14%)   9/48 (19%)  |0/49 (0%)    1/49 (2%)    1/49 (2%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     1/37.91      3/42.41      7/42.56      9/27.58     |0/42.42      1/42.55      1/45.12      1/42.03      | 
|POLY-3 PERCENT (g) |     2.6%         7.1%         16.5%        32.6%       |0.0%         2.4%         2.2%         2.4%         | 
|TERMINAL (d)       |     1/23 (4%)    3/27 (11%)   5/27 (19%)   0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      598          564         |---          585          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.362      P=0.053      P<0.001 **  |P=0.523      P=0.509      P=0.547      P=0.507      | 
|POLY 3             |     P<0.001 **   P=0.346      P=0.043 *    P<0.001 **  |P=0.527      P=0.501      P=0.512      P=0.498      | 
|POLY 1.5           |     P=0.002 **   P=0.340      P=0.041 *    P=0.003 **  |P=0.524      P=0.501      P=0.508      P=0.497      | 
|POLY 6             |     P<0.001 **   P=0.354      P=0.043 *    P<0.001 **  |P=0.527      P=0.500      P=0.518      P=0.498      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.362      P=0.044 *    P<0.001 **  |P=0.508      P=0.476      P=0.547      P=0.507      | 
|COCH-ARM / FISHERS |     P=0.008 **   P=0.332      P=0.036 *    P=0.008 **  |P=0.515      P=0.500      P=0.500      P=0.490      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/48 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/39.90      0/42.41      0/42.00      2/25.18     |0/43.16      2/43.04      0/45.88      0/43.15      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.9%        |0.0%         4.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    2/31 (7%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          449         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   (e)          (e)          P=0.053     |P=0.390N     P=0.245      (e)          (e)          | 
|POLY 3             |     P=0.023 *    (e)          (e)          P=0.151     |P=0.396N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.029 *    (e)          (e)          P=0.186     |P=0.394N     P=0.237      (e)          (e)          | 
|POLY 6             |     P=0.019 *    (e)          (e)          P=0.107     |P=0.400N     P=0.235      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.105      (e)          (e)          P=0.295     |(e)          P=0.245      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.039 *    (e)          (e)          P=0.237     |P=0.394N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/50 (48%)  35/50 (70%)  26/49 (53%)  45/48 (94%) |46/50 (92%)  46/50 (92%)  49/50 (98%)  46/49 (94%)  | 
|POLY-3 RATE (b)    |     24/41.13     35/45.03     26/44.36     45/46.57    |46/47.92     46/48.28     49/49.07     46/47.84     | 
|POLY-3 PERCENT (g) |     58.4%        77.7%        58.6%        96.6%       |96.0%        95.3%        99.9%        96.2%        | 
|TERMINAL (d)       |     18/23 (78%)  25/27 (93%)  18/27 (67%)  0/0 (0%)    |30/30 (100%) 31/31 (100%) 38/38 (100%) 31/31 (100%) | 
|FIRST INCIDENCE    |     565          456          543          398         |413          425          597          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.125      P=0.452N     P<0.001 **  |P=0.531      P=0.509N     P=0.156N     P=0.519N     | 
|POLY 3             |     P<0.001 **   P=0.031 *    P=0.581      P<0.001 **  |P=0.677N     P=0.651N     P=0.221      P=0.715      | 
|POLY 1.5           |     P<0.001 **   P=0.026 *    P=0.510      P<0.001 **  |P=0.623      P=0.621N     P=0.175      P=0.656      | 
|POLY 6             |     P<0.001 **   P=0.039 *    P=0.534N     P<0.001 **  |P=0.684N     P=0.735N     P=0.356      P=0.765N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.031 *    P=0.550      P<0.001 **  |P=0.518N     P=0.625N     P=0.299      P=0.611N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.021 *    P=0.381      P<0.001 **  |P=0.493      P=0.643N     P=0.181      P=0.511      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  22/50 (44%)  23/49 (47%)  2/48 (4%)   |10/50 (20%)  16/50 (32%)  20/50 (40%)  17/49 (35%)  | 
|POLY-3 RATE (b)    |     22/40.34     22/42.41     23/42.12     2/25.35     |10/43.29     16/43.58     20/45.88     17/43.15     | 
|POLY-3 PERCENT (g) |     54.5%        51.9%        54.6%        7.9%        |23.1%        36.7%        43.6%        39.4%        | 
|TERMINAL (d)       |     19/23 (83%)  22/27 (82%)  21/27 (78%)  0/0 (0%)    |9/30 (30%)   14/31 (45%)  20/38 (53%)  17/31 (55%)  | 
|FIRST INCIDENCE    |     654          729 (T)      712          438         |697          626          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.095      P=0.214N     P=0.329N     P=0.167     |P=0.185      P=0.130      P=0.093      P=0.081      | 
|POLY 3             |     P<0.001N**   P=0.491N     P=0.589      P<0.001N**  |P=0.204      P=0.121      P=0.031 *    P=0.076      | 
|POLY 1.5           |     P<0.001N**   P=0.522N     P=0.551      P<0.001N**  |P=0.211      P=0.125      P=0.028 *    P=0.080      | 
|POLY 6             |     P=0.013N*    P=0.440N     P=0.580N     P=0.002N**  |P=0.184      P=0.119      P=0.035 *    P=0.068      | 
|LOGISTIC REGRESSION|     P=0.583      P=0.132N     P=0.370N     P=0.281N    |P=0.174      P=0.110      P=0.060      P=0.069      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.580N     P=0.463      P<0.001N**  |P=0.203      P=0.127      P=0.024 *    P=0.078      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    6/49 (12%)   2/48 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/40.18      3/42.71      6/42.59      2/24.96     |0/43.16      0/43.04      0/45.88      0/43.15      | 
|POLY-3 PERCENT (g) |     10.0%        7.0%         14.1%        8.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/23 (13%)   1/27 (4%)    4/27 (15%)   0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     654          684          649          561         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.411N     P=0.436      P=0.073     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.579      P=0.467N     P=0.406      P=0.567N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.457N     P=0.479N     P=0.391      P=0.460N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.338      P=0.447N     P=0.422      P=0.581     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.505      P=0.453N     P=0.409      P=0.592     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.302N     P=0.500N     P=0.357      P=0.359N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/49 (4%)    0/48 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/39.90      0/42.41      2/42.05      0/24.20     |0/43.16      0/43.04      1/45.88      4/43.74      | 
|POLY-3 PERCENT (g) |     2.5%         0.0%         4.8%         0.0%        |0.0%         0.0%         2.2%         9.1%         | 
|TERMINAL (d)       |     1/23 (4%)    0/27 (0%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    3/31 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          718          ---         |---          ---          729 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.869      P=0.468N     P=0.563      P=1.000N    |P=0.005 **   (e)          P=0.547      P=0.069      | 
|POLY 3             |     P=0.604N     P=0.488N     P=0.518      P=0.595N    |P=0.005 **   (e)          P=0.512      P=0.062      | 
|POLY 1.5           |     P=0.530N     P=0.492N     P=0.511      P=0.552N    |P=0.005 **   (e)          P=0.508      P=0.061      | 
|POLY 6             |     P=0.546      P=0.481N     P=0.526      P=0.659N    |P=0.005 **   (e)          P=0.517      P=0.061      | 
|LOGISTIC REGRESSION|     P=0.843      (e)          P=0.551      (e)         |P=0.005 **   (e)          P=0.547      P=0.058      | 
|COCH-ARM / FISHERS |     P=0.447N     P=0.500N     P=0.492      P=0.510N    |P=0.005 **   (e)          P=0.500      P=0.056      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   3/49 (6%)    5/48 (10%)  |6/50 (12%)   9/50 (18%)   6/50 (12%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     6/41.34      5/43.03      3/43.35      5/27.08     |6/43.97      9/46.83      6/48.13      4/44.22      | 
|POLY-3 PERCENT (g) |     14.5%        11.6%        6.9%         18.5%       |13.6%        19.2%        12.5%        9.1%         | 
|TERMINAL (d)       |     1/23 (4%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |1/30 (3%)    1/31 (3%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     564          614          583          398         |596          417          597          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.396N     P=0.208N     P=0.093     |P=0.194N     P=0.301      P=0.536N     P=0.385N     | 
|POLY 3             |     P=0.368      P=0.472N     P=0.217N     P=0.462     |P=0.184N     P=0.334      P=0.556N     P=0.366N     | 
|POLY 1.5           |     P=0.470      P=0.480N     P=0.227N     P=0.595     |P=0.181N     P=0.318      P=0.582N     P=0.368N     | 
|POLY 6             |     P=0.261      P=0.458N     P=0.209N     P=0.253     |P=0.193N     P=0.351      P=0.525N     P=0.367N     | 
|LOGISTIC REGRESSION|     P=0.372N     P=0.493N     P=0.321N     P=0.430N    |P=0.246N     P=0.267      P=0.558      P=0.397N     | 
|COCH-ARM / FISHERS |     P=0.579N     P=0.500N     P=0.254N     P=0.529N    |P=0.182N     P=0.288      P=0.620N     P=0.383N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   4/49 (8%)    5/48 (10%)  |4/50 (8%)    7/50 (14%)   6/50 (12%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |     3/40.56      5/43.14      4/43.28      5/27.01     |4/43.29      7/43.29      6/47.29      6/43.69      | 
|POLY-3 PERCENT (g) |     7.4%         11.6%        9.2%         18.5%       |9.2%         16.2%        12.7%        13.7%        | 
|TERMINAL (d)       |     2/23 (9%)    3/27 (11%)   1/27 (4%)    0/0 (0%)    |2/30 (7%)    4/31 (13%)   3/38 (8%)    5/31 (16%)   | 
|FIRST INCIDENCE    |     511          564          562          408         |697          683          295          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011 *    P=0.424      P=0.545      P=0.030 *   |P=0.482      P=0.276      P=0.483      P=0.383      | 
|POLY 3             |     P=0.174      P=0.390      P=0.536      P=0.164     |P=0.497      P=0.259      P=0.426      P=0.375      | 
|POLY 1.5           |     P=0.259      P=0.378      P=0.520      P=0.241     |P=0.495      P=0.262      P=0.406      P=0.372      | 
|POLY 6             |     P=0.094      P=0.411      P=0.553      P=0.077     |P=0.492      P=0.257      P=0.447      P=0.373      | 
|LOGISTIC REGRESSION|     P=0.570      P=0.360      P=0.422      P=0.467     |P=0.481      P=0.253      P=0.330      P=0.367      | 
|COCH-ARM / FISHERS |     P=0.382      P=0.357      P=0.489      P=0.335     |P=0.479      P=0.262      P=0.370      P=0.357      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Focal Granulomatous                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  26/50 (52%)  42/49 (86%)  27/48 (56%) |30/50 (60%)  33/50 (66%)  37/50 (74%)  26/49 (53%)  | 
|POLY-3 RATE (b)    |     22/41.38     26/43.29     42/47.70     27/37.84    |30/45.32     33/44.70     37/47.21     26/45.05     | 
|POLY-3 PERCENT (g) |     50.8%        60.1%        88.1%        71.4%       |66.2%        73.8%        78.4%        57.7%        | 
|TERMINAL (d)       |     18/23 (78%)  22/27 (82%)  25/27 (93%)  0/0 (0%)    |22/30 (73%)  27/31 (87%)  32/38 (84%)  20/31 (65%)  | 
|FIRST INCIDENCE    |     376          564          543          398         |413          425          597          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.451      P<0.001 **   P<0.001 **  |P=0.104N     P=0.395      P=0.579      P=0.248N     | 
|POLY 3             |     P=0.078      P=0.250      P<0.001 **   P=0.034 *   |P=0.064N     P=0.277      P=0.129      P=0.263N     | 
|POLY 1.5           |     P=0.160      P=0.235      P<0.001 **   P=0.066     |P=0.077N     P=0.311      P=0.115      P=0.273N     | 
|POLY 6             |     P=0.020 *    P=0.289      P<0.001 **   P=0.010 *   |P=0.056N     P=0.235      P=0.151      P=0.261N     | 
|LOGISTIC REGRESSION|     P=0.007 **   P=0.340      P<0.001 **   P=0.031 *   |P=0.081N     P=0.315      P=0.188      P=0.262N     | 
|COCH-ARM / FISHERS |     P=0.300      P=0.212      P<0.001 **   P=0.113     |P=0.116N     P=0.339      P=0.101      P=0.311N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Focal Histiocytic                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  27/50 (54%)  46/49 (94%)  48/48 (100%)|39/50 (78%)  37/50 (74%)  36/50 (72%)  28/49 (57%)  | 
|POLY-3 RATE (b)    |     18/42.07     27/45.35     46/47.59     48/48.00    |39/47.86     37/45.45     36/47.19     28/44.68     | 
|POLY-3 PERCENT (g) |     42.8%        59.5%        96.7%        100.0%      |81.5%        81.4%        76.3%        62.7%        | 
|TERMINAL (d)       |     12/23 (52%)  17/27 (63%)  27/27 (100%) 0/0 (0%)    |26/30 (87%)  29/31 (94%)  31/38 (82%)  23/31 (74%)  | 
|FIRST INCIDENCE    |     376          505          543          398         |247          425          597          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.180      P<0.001 **   P<0.001 **  |P=0.014N*    P=0.369N     P=0.036N*    P=0.021N*    | 
|POLY 3             |     P<0.001 **   P=0.080      P<0.001 **   P<0.001 **  |P=0.009N**   P=0.609N     P=0.350N     P=0.028N*    | 
|POLY 1.5           |     P<0.001 **   P=0.068      P<0.001 **   P<0.001 **  |P=0.009N**   P=0.520N     P=0.346N     P=0.023N*    | 
|POLY 6             |     P<0.001 **   P=0.106      P<0.001 **   P<0.001 **  |P=0.011N*    P=0.508      P=0.359N     P=0.042N*    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.074      P<0.001 **   P<0.001 **  |P=0.006N**   P=0.396N     P=0.241N     P=0.015N*    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.054      P<0.001 **   P<0.001 **  |P=0.012N*    P=0.408N     P=0.322N     P=0.022N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/49 (4%)    2/48 (4%)   |1/50 (2%)    7/50 (14%)   7/50 (14%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     0/39.90      2/42.41      2/42.00      2/25.25     |1/43.29      7/43.04      7/46.11      4/43.66      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         4.8%         7.9%        |2.3%         16.3%        15.2%        9.2%         | 
|TERMINAL (d)       |     0/23 (0%)    2/27 (7%)    2/27 (7%)    0/0 (0%)    |0/30 (0%)    7/31 (23%)   6/38 (16%)   3/31 (10%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      398         |697          729 (T)      667          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.274      P=0.274      P=0.057     |P=0.592N     P=0.034 *    P=0.061      P=0.184      | 
|POLY 3             |     P=0.203      P=0.251      P=0.248      P=0.151     |P=0.574N     P=0.029 *    P=0.037 *    P=0.181      | 
|POLY 1.5           |     P=0.278      P=0.246      P=0.244      P=0.187     |P=0.577N     P=0.030 *    P=0.034 *    P=0.180      | 
|POLY 6             |     P=0.114      P=0.258      P=0.253      P=0.107     |P=0.577N     P=0.027 *    P=0.040 *    P=0.180      | 
|LOGISTIC REGRESSION|     P=0.272      P=0.274      P=0.274      P=0.304     |P=0.590N     P=0.030 *    P=0.041 *    P=0.175      | 
|COCH-ARM / FISHERS |     P=0.369      P=0.247      P=0.242      P=0.237     |P=0.586      P=0.030 *    P=0.030 *    P=0.175      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/49 (0%)    0/48 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/40.95      0/42.41      0/42.00      0/24.20     |0/43.16      0/43.04      0/45.88      0/43.15      | 
|POLY-3 PERCENT (g) |     7.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     565          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.353N     P=0.117N     P=0.121N     P=0.425N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.207N     P=0.112N     P=0.114N     P=0.239N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.210N     P=0.114N     P=0.115N     P=0.176N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.157N     P=0.109N     P=0.113N     P=0.369N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.144N     P=0.136N     P=0.149N     P=0.113N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.193N     P=0.121N     P=0.125N     P=0.129N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  38/50 (76%)  43/49 (88%)  44/48 (92%) |2/50 (4%)    3/50 (6%)    7/50 (14%)   18/49 (37%)  | 
|POLY-3 RATE (b)    |     34/45.22     38/45.81     43/48.11     44/46.58    |2/43.16      3/43.84      7/46.11      18/44.26     | 
|POLY-3 PERCENT (g) |     75.2%        83.0%        89.4%        94.5%       |4.6%         6.8%         15.2%        40.7%        | 
|TERMINAL (d)       |     17/23 (74%)  22/27 (82%)  24/27 (89%)  0/0 (0%)    |2/30 (7%)    1/31 (3%)    5/38 (13%)   14/31 (45%)  | 
|FIRST INCIDENCE    |     564          417          543          398         |729 (T)      585          681          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.492N     P=0.296      P<0.001 **  |P<0.001 **   P=0.511      P=0.145      P<0.001 **   | 
|POLY 3             |     P=0.009 **   P=0.243      P=0.052      P=0.005 **  |P<0.001 **   P=0.507      P=0.095      P<0.001 **   | 
|POLY 1.5           |     P=0.008 **   P=0.265      P=0.036 *    P=0.005 **  |P<0.001 **   P=0.505      P=0.089      P<0.001 **   | 
|POLY 6             |     P=0.010 *    P=0.215      P=0.071      P=0.004 **  |P<0.001 **   P=0.511      P=0.103      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.357      P=0.035 *    P<0.001 **  |P<0.001 **   P=0.500      P=0.106      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.252      P=0.016 *    P=0.003 **  |P<0.001 **   P=0.500      P=0.080      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/50 (30%)  11/50 (22%)  12/49 (24%)  3/48 (6%)   |6/50 (12%)   8/50 (16%)   2/50 (4%)    6/49 (12%)   | 
|POLY-3 RATE (b)    |     15/43.85     11/44.78     12/44.55     3/25.63     |6/44.68      8/45.73      2/46.21      6/44.90      | 
|POLY-3 PERCENT (g) |     34.2%        24.6%        26.9%        11.7%       |13.4%        17.5%        4.3%         13.4%        | 
|TERMINAL (d)       |     2/23 (9%)    1/27 (4%)    3/27 (11%)   0/0 (0%)    |1/30 (3%)    1/31 (3%)    1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     511          550          584          408         |540          417          638          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560      P=0.187N     P=0.272N     P=0.624     |P=0.541N     P=0.406      P=0.101N     P=0.611N     | 
|POLY 3             |     P=0.070N     P=0.221N     P=0.304N     P=0.040N*   |P=0.545N     P=0.404      P=0.122N     P=0.618N     | 
|POLY 1.5           |     P=0.019N*    P=0.227N     P=0.311N     P=0.010N*   |P=0.545N     P=0.401      P=0.126N     P=0.620N     | 
|POLY 6             |     P=0.239N     P=0.215N     P=0.306N     P=0.222N    |P=0.548N     P=0.405      P=0.118N     P=0.619N     | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.273N     P=0.409N     P=0.003N**  |P=0.537      P=0.366      P=0.157N     P=0.540      | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.247N     P=0.349N     P=0.002N**  |P=0.552N     P=0.387      P=0.134N     P=0.606      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  35/49 (71%)  39/50 (78%)  34/49 (69%) |46/50 (92%)  47/50 (94%)  46/50 (92%)  45/49 (92%)  | 
|POLY-3 RATE (b)    |     32/43.43     35/46.15     39/47.51     34/40.73    |46/48.75     47/48.77     46/48.38     45/48.43     | 
|POLY-3 PERCENT (g) |     73.7%        75.8%        82.1%        83.5%       |94.4%        96.4%        95.1%        92.9%        | 
|TERMINAL (d)       |     20/23 (87%)  22/27 (82%)  23/27 (85%)  0/0 (0%)    |30/30 (100%) 31/31 (100%) 37/38 (97%)  31/31 (100%) | 
|FIRST INCIDENCE    |     564          456          543          438         |247          425          597          533          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.451N     P=0.394      P<0.001 **  |P=0.467N     P=0.561      P=0.057N     P=0.431N     | 
|POLY 3             |     P=0.171      P=0.504      P=0.223      P=0.172     |P=0.367N     P=0.503      P=0.630      P=0.554N     | 
|POLY 1.5           |     P=0.311      P=0.418      P=0.161      P=0.265     |P=0.421N     P=0.487      P=0.611      P=0.587N     | 
|POLY 6             |     P=0.062      P=0.607N     P=0.320      P=0.076     |P=0.325N     P=0.565      P=0.689      P=0.521N     | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.406      P=0.150      P=0.028 *   |P=0.415N     P=0.527      P=0.529N     P=0.602N     | 
|COCH-ARM / FISHERS |     P=0.514      P=0.283      P=0.093      P=0.361     |P=0.516N     P=0.500      P=0.643N     P=0.631N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/49 (4%)    4/50 (8%)    1/49 (2%)   |8/50 (16%)   4/50 (8%)    8/50 (16%)   11/49 (22%)  | 
|POLY-3 RATE (b)    |     3/39.90      2/41.97      4/42.58      1/24.74     |8/43.79      4/43.04      8/45.89      11/43.58     | 
|POLY-3 PERCENT (g) |     7.5%         4.8%         9.4%         4.0%        |18.3%        9.3%         17.4%        25.2%        | 
|TERMINAL (d)       |     3/23 (13%)   2/27 (7%)    3/27 (11%)   0/0 (0%)    |7/30 (23%)   4/31 (13%)   7/38 (18%)   9/31 (29%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      586          690         |527          729 (T)      725          652          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.426N     P=0.585      P=0.005 **  |P=0.082      P=0.160N     P=0.416N     P=0.325      | 
|POLY 3             |     P=0.504N     P=0.477N     P=0.536      P=0.488N    |P=0.087      P=0.183N     P=0.568N     P=0.297      | 
|POLY 1.5           |     P=0.389N     P=0.489N     P=0.524      P=0.397N    |P=0.087      P=0.180N     P=0.582N     P=0.299      | 
|POLY 6             |     P=0.486      P=0.459N     P=0.550      P=0.637N    |P=0.085      P=0.188N     P=0.551N     P=0.292      | 
|LOGISTIC REGRESSION|     P=0.455      P=0.426N     P=0.539      P=0.199     |P=0.080      P=0.179N     P=0.542N     P=0.299      | 
|COCH-ARM / FISHERS |     P=0.267N     P=0.510N     P=0.500      P=0.316N    |P=0.083      P=0.178N     P=0.607N     P=0.288      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    3/50 (6%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/40.18      1/41.97      3/42.10      0/24.59     |0/43.16      0/43.04      1/45.88      0/43.15      | 
|POLY-3 PERCENT (g) |     2.5%         2.4%         7.1%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    1/27 (4%)    3/27 (11%)   0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     653          729 (T)      729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.679      P=0.740N     P=0.341      P=0.912N    |P=0.779N     (e)          P=0.547      (e)          | 
|POLY 3             |     P=0.515N     P=0.751N     P=0.322      P=0.593N    |P=0.772N     (e)          P=0.512      (e)          | 
|POLY 1.5           |     P=0.411N     P=0.756N     P=0.317      P=0.549N    |P=0.772N     (e)          P=0.508      (e)          | 
|POLY 6             |     P=0.518      P=0.744N     P=0.325      P=0.659N    |P=0.773N     (e)          P=0.517      (e)          | 
|LOGISTIC REGRESSION|     P=0.791      P=0.758N     P=0.331      P=0.614N    |(e)          (e)          P=0.547      (e)          | 
|COCH-ARM / FISHERS |     P=0.307N     P=0.747      P=0.309      P=0.505N    |P=0.776N     (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/50 (2%)    3/49 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/39.90      2/42.98      1/42.29      3/26.60     |1/44.12      0/43.04      0/45.88      0/43.15      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.4%         11.3%       |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          456          682          398         |247          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.257      P=0.519      P=0.098     |P=0.547N     P=0.500N     P=0.500N     P=0.500N     | 
|POLY 3             |     P=0.070      P=0.254      P=0.512      P=0.062     |P=0.550N     P=0.505N     P=0.492N     P=0.504N     | 
|POLY 1.5           |     P=0.097      P=0.246      P=0.508      P=0.085     |P=0.550N     P=0.503N     P=0.496N     P=0.504N     | 
|POLY 6             |     P=0.045 *    P=0.266      P=0.516      P=0.037 *   |P=0.552N     P=0.507N     P=0.487N     P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.349      P=0.148      P=0.505      P=0.164     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.138      P=0.242      P=0.500      P=0.117     |P=0.551N     P=0.500N     P=0.500N     P=0.505N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  18/49 (37%)  10/50 (20%)  5/49 (10%)  |11/50 (22%)  15/50 (30%)  17/50 (34%)  8/49 (16%)   | 
|POLY-3 RATE (b)    |     11/40.86     18/43.97     10/42.12     5/26.59     |11/44.58     15/44.26     17/45.92     8/43.76      | 
|POLY-3 PERCENT (g) |     26.9%        40.9%        23.7%        18.8%       |24.7%        33.9%        37.0%        18.3%        | 
|TERMINAL (d)       |     7/23 (30%)   12/27 (44%)  9/27 (33%)   0/0 (0%)    |7/30 (23%)   12/31 (39%)  16/38 (42%)  7/31 (23%)   | 
|FIRST INCIDENCE    |     653          558          725          586         |413          585          717          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.195      P=0.365N     P=0.006 **  |P=0.099N     P=0.274      P=0.325      P=0.291N     | 
|POLY 3             |     P=0.112N     P=0.125      P=0.468N     P=0.321N    |P=0.101N     P=0.234      P=0.146      P=0.318N     | 
|POLY 1.5           |     P=0.041N*    P=0.106      P=0.473N     P=0.182N    |P=0.100N     P=0.240      P=0.141      P=0.315N     | 
|POLY 6             |     P=0.307N     P=0.156      P=0.472N     P=0.609N    |P=0.109N     P=0.229      P=0.152      P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.390N     P=0.115      P=0.408N     P=0.560     |P=0.099N     P=0.246      P=0.172      P=0.315N     | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.082      P=0.500N     P=0.093N    |P=0.110N     P=0.247      P=0.133      P=0.323N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/39.90      0/41.97      0/42.10      0/24.59     |1/43.27      2/43.04      3/45.88      2/43.15      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.7%         6.5%         4.6%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    2/31 (7%)    3/38 (8%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |702          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.540      P=0.511      P=0.387      P=0.508      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.545      P=0.498      P=0.326      P=0.499      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.545      P=0.500      P=0.319      P=0.499      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.542      P=0.495      P=0.335      P=0.496      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.533      P=0.497      P=0.342      P=0.496      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.536      P=0.500      P=0.309      P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/39.90      0/42.41      1/42.17      2/26.66     |0/43.16      1/43.04      0/45.88      1/43.66      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         2.4%         7.5%        |0.0%         2.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     2/23 (9%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          712          438         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      P=0.203N     P=0.438N     P=0.233     |P=0.475      P=0.507      (e)          P=0.507      | 
|POLY 3             |     P=0.264      P=0.223N     P=0.481N     P=0.541     |P=0.479      P=0.499      (e)          P=0.502      | 
|POLY 1.5           |     P=0.320      P=0.228N     P=0.487N     P=0.622     |P=0.480      P=0.500      (e)          P=0.503      | 
|POLY 6             |     P=0.202      P=0.216N     P=0.474N     P=0.401     |P=0.475      P=0.498      (e)          P=0.500      | 
|LOGISTIC REGRESSION|     P=0.500      (e)          P=0.456N     P=0.644N    |(e)          P=0.507      (e)          P=0.507      | 
|COCH-ARM / FISHERS |     P=0.395      P=0.247N     P=0.500N     P=0.691N    |P=0.478      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Deep Cervical                                                                                                        | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/18 (0%)    0/14 (0%)    0/21 (0%)    0/9 (0%)    |0/15 (0%)    0/11 (0%)    2/8 (25%)    0/14 (0%)    | 
|POLY-3 RATE (b)    |     0/15.01      0/11.89      0/18.44      0/4.53      |0/12.41      0/8.32       2/5.93       0/12.98      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         33.7%        0.0%         | 
|TERMINAL (d)       |     0/7 (0%)     0/6 (0%)     0/10 (0%)    0/0 (0%)    |0/6 (0%)     0/6 (0%)     2/4 (50%)    0/9 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.529N     (e)          P=0.142      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.580N     (e)          P=0.075      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.596N     (e)          P=0.082      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.564N     (e)          P=0.067      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.142      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.619N     (e)          P=0.111      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/41 (0%)    1/47 (2%)    0/44 (0%)   |3/50 (6%)    3/49 (6%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/38.11      0/36.12      1/39.85      0/22.54     |3/43.42      3/42.79      1/45.88      1/43.27      | 
|POLY-3 PERCENT (g) |     2.6%         0.0%         2.5%         0.0%        |6.9%         7.0%         2.2%         2.3%         | 
|TERMINAL (d)       |     1/22 (5%)    0/25 (0%)    0/26 (0%)    0/0 (0%)    |2/30 (7%)    2/31 (7%)    1/38 (3%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          725          ---         |659          622          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.989      P=0.475N     P=0.715N     P=1.000N    |P=0.232N     P=0.655N     P=0.240N     P=0.300N     | 
|POLY 3             |     P=0.575N     P=0.511N     P=0.751N     P=0.599N    |P=0.235N     P=0.656      P=0.286N     P=0.306N     | 
|POLY 1.5           |     P=0.536N     P=0.519N     P=0.756N     P=0.559N    |P=0.233N     P=0.656      P=0.293N     P=0.306N     | 
|POLY 6             |     P=0.611N     P=0.500N     P=0.746N     P=0.662N    |P=0.240N     P=0.657      P=0.278N     P=0.310N     | 
|LOGISTIC REGRESSION|     P=0.982      (e)          P=0.725N     (e)         |P=0.230N     P=0.655      P=0.283N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.484N     P=0.539N     P=0.747      P=0.522N    |P=0.235N     P=0.651      P=0.309N     P=0.316N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/14 (86%)  9/11 (82%)   5/6 (83%)    4/4 (100%)  |14/15 (93%)  13/13 (100%) 11/13 (85%)  8/11 (73%)   | 
|POLY-3 RATE (b)    |     12/13.52     9/9.90       5/6.00       4/4.00      |14/14.41     13/13.00     11/12.23     8/10.02      | 
|POLY-3 PERCENT (g) |     88.8%        90.9%        83.3%        100.0%      |97.2%        100.0%       90.0%        79.8%        | 
|TERMINAL (d)       |     4/4 (100%)   4/4 (100%)   3/4 (75%)    0/0 (0%)    |9/9 (100%)   8/8 (100%)   6/6 (100%)   5/5 (100%)   | 
|FIRST INCIDENCE    |     376          649          340          598         |659          417          295          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.171      P=0.223N     P=0.026N*    P=0.219     |P=0.291N     P=0.622      P=0.549N     P=0.376N     | 
|POLY 3             |     P=0.544      P=0.726      P=0.660N     P=0.633     |P=0.048N*    P=0.930      P=0.518N     P=0.193N     | 
|POLY 1.5           |     P=0.481      P=0.736N     P=0.680N     P=0.583     |P=0.049N*    P=0.732      P=0.470N     P=0.184N     | 
|POLY 6             |     P=0.658      P=0.715      P=0.616N     P=0.743     |P=0.056N     P=1.000      P=0.708N     P=0.243N     | 
|LOGISTIC REGRESSION|     P=0.403      P=0.525N     P=0.741N     P=0.578     |P=0.050N     P=0.275      P=0.645N     P=0.386N     | 
|COCH-ARM / FISHERS |     P=0.417      P=0.604N     P=0.681N     P=0.595     |P=0.056N     P=0.536      P=0.444N     P=0.188N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/48 (0%)    0/48 (0%)    0/46 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/37.87      2/42.41      0/42.10      0/24.79     |0/42.01      0/41.44      0/43.82      0/43.15      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    2/27 (7%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.970N     P=0.274      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.425N     P=0.262      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.413N     P=0.260      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.399N     P=0.267      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.274      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.386N     P=0.269      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/46 (24%)  17/50 (34%)  15/50 (30%)  6/49 (12%)  |10/48 (21%)  5/48 (10%)   7/46 (15%)   4/49 (8%)    | 
|POLY-3 RATE (b)    |     11/40.99     17/44.82     15/45.27     6/27.31     |10/43.93     5/41.67      7/43.82      4/44.11      | 
|POLY-3 PERCENT (g) |     26.8%        37.9%        33.1%        22.0%       |22.8%        12.0%        16.0%        9.1%         | 
|TERMINAL (d)       |     6/23 (26%)   8/27 (30%)   5/27 (19%)   0/0 (0%)    |3/30 (10%)   3/31 (10%)   7/38 (18%)   2/31 (7%)    | 
|FIRST INCIDENCE    |     376          554          562          561         |413          683          729 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.089      P=0.242      P=0.372      P=0.178     |P=0.147N     P=0.146N     P=0.189N     P=0.088N     | 
|POLY 3             |     P=0.254N     P=0.191      P=0.343      P=0.434N    |P=0.118N     P=0.152N     P=0.297N     P=0.069N     | 
|POLY 1.5           |     P=0.095N     P=0.190      P=0.336      P=0.252N    |P=0.118N     P=0.141N     P=0.306N     P=0.066N     | 
|POLY 6             |     P=0.522      P=0.208      P=0.362      P=0.482     |P=0.123N     P=0.166N     P=0.290N     P=0.076N     | 
|LOGISTIC REGRESSION|     P=0.020N*    P=0.182      P=0.294      P=0.087N    |P=0.125N     P=0.130N     P=0.363N     P=0.079N     | 
|COCH-ARM / FISHERS |     P=0.018N*    P=0.195      P=0.330      P=0.112N    |P=0.124N     P=0.130N     P=0.331N     P=0.068N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/46 (4%)    5/50 (10%)   4/50 (8%)    9/49 (18%)  |1/48 (2%)    4/48 (8%)    0/46 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     2/38.23      5/43.57      4/43.28      9/29.79     |1/42.09      4/43.71      0/43.82      3/44.59      | 
|POLY-3 PERCENT (g) |     5.2%         11.5%        9.2%         30.2%       |2.4%         9.2%         0.0%         6.7%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     676          554          584          408         |709          417          ---          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.296      P=0.367      P<0.001 **  |P=0.413      P=0.191      P=0.462N     P=0.321      | 
|POLY 3             |     P=0.004 **   P=0.271      P=0.395      P=0.006 **  |P=0.430      P=0.190      P=0.492N     P=0.326      | 
|POLY 1.5           |     P=0.010 *    P=0.263      P=0.389      P=0.014 *   |P=0.430      P=0.187      P=0.498N     P=0.323      | 
|POLY 6             |     P<0.001 **   P=0.285      P=0.403      P<0.001 **  |P=0.428      P=0.192      P=0.486N     P=0.327      | 
|LOGISTIC REGRESSION|     P=0.135      P=0.246      P=0.364      P=0.114     |P=0.251      P=0.141      P=0.499N     P=0.232      | 
|COCH-ARM / FISHERS |     P=0.025 *    P=0.254      P=0.379      P=0.032 *   |P=0.423      P=0.181      P=0.511N     P=0.316      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/46 (9%)    3/50 (6%)    3/50 (6%)    34/49 (69%) |0/48 (0%)    0/48 (0%)    1/46 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/39.22      3/42.49      3/42.65      34/41.78    |0/42.01      0/41.44      1/43.82      0/43.15      | 
|POLY-3 PERCENT (g) |     10.2%        7.1%         7.0%         81.4%       |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    2/27 (7%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     564          709          627          398         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.447N     P=0.470N     P<0.001 **  |P=0.779N     (e)          P=0.547      (e)          | 
|POLY 3             |     P<0.001 **   P=0.456N     P=0.454N     P<0.001 **  |P=0.764N     (e)          P=0.508      (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.454N     P=0.452N     P<0.001 **  |P=0.764N     (e)          P=0.503      (e)          | 
|POLY 6             |     P<0.001 **   P=0.456N     P=0.458N     P<0.001 **  |P=0.766N     (e)          P=0.515      (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.460N     P=0.475N     P<0.001 **  |(e)          (e)          P=0.547      (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.453N     P=0.453N     P<0.001 **  |P=0.767N     (e)          P=0.489      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/50 (0%)    0/50 (0%)    7/49 (14%)  |0/48 (0%)    0/48 (0%)    0/46 (0%)    9/49 (18%)   | 
|POLY-3 RATE (b)    |     0/37.87      0/42.41      0/42.10      7/28.36     |0/42.01      0/41.44      0/43.82      9/45.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         24.7%       |0.0%         0.0%         0.0%         19.9%        | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    3/31 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          398         |---          ---          ---          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P<0.001 **  |P<0.001 **   (e)          (e)          P=0.004 **   | 
|POLY 3             |     P<0.001 **   (e)          (e)          P=0.002 **  |P<0.001 **   (e)          (e)          P=0.002 **   | 
|POLY 1.5           |     P<0.001 **   (e)          (e)          P=0.004 **  |P<0.001 **   (e)          (e)          P=0.002 **   | 
|POLY 6             |     P<0.001 **   (e)          (e)          P<0.001 **  |P<0.001 **   (e)          (e)          P=0.003 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          (e)          P=0.037 *   |P<0.001 **   (e)          (e)          P=0.002 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          (e)          P=0.008 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/46 (9%)    1/50 (2%)    0/50 (0%)    2/49 (4%)   |0/48 (0%)    0/48 (0%)    2/46 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/38.40      1/42.41      0/42.10      2/25.72     |0/42.01      0/41.44      2/43.82      1/43.74      | 
|POLY-3 PERCENT (g) |     10.4%        2.4%         0.0%         7.8%        |0.0%         0.0%         4.6%         2.3%         | 
|TERMINAL (d)       |     3/23 (13%)   1/27 (4%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    2/38 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     564          729 (T)      ---          561         |---          ---          729 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226      P=0.147N     P=0.049N*    P=0.324     |P=0.419      (e)          P=0.292      P=0.513      | 
|POLY 3             |     P=0.624      P=0.148N     P=0.048N*    P=0.531N    |P=0.443      (e)          P=0.247      P=0.508      | 
|POLY 1.5           |     P=0.603N     P=0.151N     P=0.049N*    P=0.419N    |P=0.439      (e)          P=0.240      P=0.508      | 
|POLY 6             |     P=0.590N     P=0.144N     P=0.048N*    P=0.608     |P=0.443      (e)          P=0.254      P=0.507      | 
|LOGISTIC REGRESSION|     P=0.651N     P=0.148N     P=0.051N     P=0.535N    |P=0.411      (e)          P=0.292      P=0.384      | 
|COCH-ARM / FISHERS |     P=0.545N     P=0.156N     P=0.049N*    P=0.309N    |P=0.427      (e)          P=0.237      P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |40/48 (83%)  36/48 (75%)  37/46 (80%)  46/49 (94%)  | 
|POLY-3 RATE (b)    |     0/37.87      0/42.41      0/42.10      0/24.79     |40/45.54     36/46.14     37/45.55     46/47.59     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |87.8%        78.0%        81.2%        96.7%        | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |27/30 (90%)  24/31 (77%)  30/38 (79%)  31/31 (100%) | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |413          417          598          536          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.045 *    P=0.259N     P=0.037N*    P=0.221      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.014 *    P=0.155N     P=0.275N     P=0.087      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.017 *    P=0.171N     P=0.332N     P=0.097      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.012 *    P=0.143N     P=0.220N     P=0.074      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.025 *    P=0.222N     P=0.289N     P=0.133      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.020 *    P=0.226N     P=0.461N     P=0.093      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    6/50 (12%)   7/49 (14%)   8/48 (17%)   | 
|POLY-3 RATE (b)    |                                                        |4/43.75      6/43.46      7/45.57      8/43.15      | 
|POLY-3 PERCENT (g) |                                                        |9.1%         13.8%        15.4%        18.5%        | 
|TERMINAL (d)       |                                                        |3/30 (10%)   4/31 (13%)   6/38 (16%)   6/31 (19%)   | 
|FIRST INCIDENCE    |                                                        |542          624          597          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.196      P=0.391      P=0.394      P=0.195      | 
|POLY 3             |                                                        |P=0.191      P=0.365      P=0.284      P=0.168      | 
|POLY 1.5           |                                                        |P=0.189      P=0.368      P=0.271      P=0.167      | 
|POLY 6             |                                                        |P=0.191      P=0.361      P=0.301      P=0.168      | 
|LOGISTIC REGRESSION|                                                        |P=0.185      P=0.369      P=0.260      P=0.163      | 
|COCH-ARM / FISHERS |                                                        |P=0.178      P=0.370      P=0.251      P=0.159      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/44 (39%)  20/49 (41%)  12/50 (24%)  9/47 (19%)  |7/47 (15%)   10/48 (21%)  6/48 (13%)   10/48 (21%)  | 
|POLY-3 RATE (b)    |     17/38.51     20/44.71     12/42.23     9/28.60     |7/41.16      10/42.16     6/45.38      10/43.82     | 
|POLY-3 PERCENT (g) |     44.2%        44.7%        28.4%        31.5%       |17.0%        23.7%        13.2%        22.8%        | 
|TERMINAL (d)       |     8/23 (35%)   12/27 (44%)  11/27 (41%)  0/0 (0%)    |6/30 (20%)   8/31 (26%)   5/38 (13%)   6/31 (19%)   | 
|FIRST INCIDENCE    |     564          528          698          438         |697          585          638          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.535      P=0.099N     P=0.012 *   |P=0.318      P=0.315      P=0.342N     P=0.317      | 
|POLY 3             |     P=0.141N     P=0.567      P=0.102N     P=0.207N    |P=0.364      P=0.313      P=0.425N     P=0.346      | 
|POLY 1.5           |     P=0.053N     P=0.551      P=0.091N     P=0.086N    |P=0.359      P=0.315      P=0.444N     P=0.338      | 
|POLY 6             |     P=0.383N     P=0.578      P=0.131N     P=0.558N    |P=0.363      P=0.311      P=0.405N     P=0.349      | 
|LOGISTIC REGRESSION|     P=0.089N     P=0.531      P=0.078N     P=0.084N    |P=0.352      P=0.296      P=0.410N     P=0.327      | 
|COCH-ARM / FISHERS |     P=0.015N*    P=0.499      P=0.095N     P=0.034N*   |P=0.339      P=0.314      P=0.483N     P=0.314      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/44 (2%)    2/49 (4%)    2/50 (4%)    0/47 (0%)   |3/47 (6%)    2/48 (4%)    3/48 (6%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     1/36.11      2/41.98      2/42.50      0/23.65     |3/41.03      2/41.44      3/45.05      3/42.76      | 
|POLY-3 PERCENT (g) |     2.8%         4.8%         4.7%         0.0%        |7.3%         4.8%         6.7%         7.0%         | 
|TERMINAL (d)       |     1/23 (4%)    2/27 (7%)    1/27 (4%)    0/0 (0%)    |3/30 (10%)   2/31 (7%)    3/38 (8%)    3/31 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      617          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.837N     P=0.556      P=0.546      P=1.000N    |P=0.529      P=0.485N     P=0.550N     P=0.650N     | 
|POLY 3             |     P=0.380N     P=0.553      P=0.557      P=0.581N    |P=0.551      P=0.495N     P=0.619N     P=0.644N     | 
|POLY 1.5           |     P=0.306N     P=0.548      P=0.555      P=0.534N    |P=0.549      P=0.492N     P=0.630N     P=0.644N     | 
|POLY 6             |     P=0.491N     P=0.558      P=0.557      P=0.651N    |P=0.547      P=0.500N     P=0.608N     P=0.648N     | 
|LOGISTIC REGRESSION|     P=0.551N     P=0.556      P=0.552      (e)         |P=0.529      P=0.485N     P=0.550N     P=0.650N     | 
|COCH-ARM / FISHERS |     P=0.229N     P=0.541      P=0.548      P=0.484N    |P=0.540      P=0.490N     P=0.651N     P=0.651N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/44 (16%)   6/49 (12%)   4/50 (8%)    5/47 (11%)  |2/47 (4%)    1/48 (2%)    4/48 (8%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     7/36.44      6/42.08      4/42.40      5/25.56     |2/41.03      1/41.44      4/45.05      3/42.76      | 
|POLY-3 PERCENT (g) |     19.2%        14.3%        9.4%         19.6%       |4.9%         2.4%         8.9%         7.0%         | 
|TERMINAL (d)       |     4/23 (17%)   3/27 (11%)   3/27 (11%)   0/0 (0%)    |2/30 (7%)    1/31 (3%)    4/38 (11%)   3/31 (10%)   | 
|FIRST INCIDENCE    |     687          709          649          565         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.360N     P=0.191N     P<0.001 **  |P=0.361      P=0.488N     P=0.450      P=0.515      | 
|POLY 3             |     P=0.501      P=0.388N     P=0.177N     P=0.612     |P=0.391      P=0.497N     P=0.381      P=0.519      | 
|POLY 1.5           |     P=0.540N     P=0.395N     P=0.179N     P=0.483N    |P=0.388      P=0.494N     P=0.370      P=0.518      | 
|POLY 6             |     P=0.360      P=0.382N     P=0.180N     P=0.362     |P=0.387      P=0.500N     P=0.392      P=0.515      | 
|LOGISTIC REGRESSION|     P=0.172      P=0.353N     P=0.181N     P=0.264     |P=0.361      P=0.488N     P=0.450      P=0.515      | 
|COCH-ARM / FISHERS |     P=0.388N     P=0.416N     P=0.193N     P=0.333N    |P=0.376      P=0.492N     P=0.349      P=0.510      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    4/48 (8%)    1/49 (2%)    5/50 (10%)  |0/49 (0%)    0/47 (0%)    0/47 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/36.39      4/40.87      1/41.55      5/27.64     |0/42.42      0/40.75      0/43.81      2/43.15      | 
|POLY-3 PERCENT (g) |     0.0%         9.8%         2.4%         18.1%       |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/22 (0%)    1/26 (4%)    0/26 (0%)    0/0 (0%)    |0/30 (0%)    0/30 (0%)    0/36 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     ---          661          598          431         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.094      P=0.519      P=0.003 **  |P=0.040 *    (e)          (e)          P=0.245      | 
|POLY 3             |     P=0.031 *    P=0.075      P=0.526      P=0.013 *   |P=0.044 *    (e)          (e)          P=0.241      | 
|POLY 1.5           |     P=0.048 *    P=0.072      P=0.523      P=0.023 *   |P=0.044 *    (e)          (e)          P=0.241      | 
|POLY 6             |     P=0.018 *    P=0.080      P=0.530      P=0.005 **  |P=0.043 *    (e)          (e)          P=0.238      | 
|LOGISTIC REGRESSION|     P=0.128      P=0.077      P=0.483      P=0.075     |(e)          (e)          (e)          P=0.245      | 
|COCH-ARM / FISHERS |     P=0.082      P=0.067      P=0.521      P=0.037 *   |P=0.044 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/49 (0%)    0/50 (0%)    1/49 (2%)   |0/48 (0%)    0/45 (0%)    3/50 (6%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     1/38.55      0/41.97      0/42.10      1/25.11     |0/41.77      0/39.44      3/46.45      2/42.03      | 
|POLY-3 PERCENT (g) |     2.6%         0.0%         0.0%         4.0%        |0.0%         0.0%         6.5%         4.8%         | 
|TERMINAL (d)       |     1/23 (4%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    1/38 (3%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          640         |---          ---          638          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078      P=0.468N     P=0.468N     P=0.171     |P=0.197      (e)          P=0.150      P=0.245      | 
|POLY 3             |     P=0.436      P=0.483N     P=0.482N     P=0.656     |P=0.210      (e)          P=0.139      P=0.238      | 
|POLY 1.5           |     P=0.474      P=0.486N     P=0.484N     P=0.716     |P=0.208      (e)          P=0.134      P=0.237      | 
|POLY 6             |     P=0.399      P=0.477N     P=0.481N     P=0.548     |P=0.210      (e)          P=0.145      P=0.238      | 
|LOGISTIC REGRESSION|     P=0.383      (e)          (e)          P=0.526     |P=0.202      (e)          P=0.119      P=0.245      | 
|COCH-ARM / FISHERS |     P=0.526      P=0.490N     P=0.485N     P=0.742N    |P=0.200      (e)          P=0.129      P=0.242      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    4/49 (8%)    1/50 (2%)    0/49 (0%)   |0/48 (0%)    1/45 (2%)    0/50 (0%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     0/38.55      4/42.04      1/42.10      0/24.79     |0/41.77      1/39.44      0/45.88      1/42.03      | 
|POLY-3 PERCENT (g) |     0.0%         9.5%         2.4%         0.0%        |0.0%         2.5%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/23 (0%)    3/27 (11%)   1/27 (4%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          711          729 (T)      ---         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.919N     P=0.090      P=0.532      (e)         |P=0.475      P=0.507      (e)          P=0.507      | 
|POLY 3             |     P=0.294N     P=0.071      P=0.518      (e)         |P=0.483      P=0.489      (e)          P=0.501      | 
|POLY 1.5           |     P=0.241N     P=0.069      P=0.516      (e)         |P=0.482      P=0.489      (e)          P=0.500      | 
|POLY 6             |     P=0.362N     P=0.075      P=0.519      (e)         |P=0.481      P=0.488      (e)          P=0.501      | 
|LOGISTIC REGRESSION|     P=0.838N     P=0.088      P=0.532      (e)         |(e)          P=0.507      (e)          P=0.507      | 
|COCH-ARM / FISHERS |     P=0.187N     P=0.064      P=0.515      (e)         |P=0.477      P=0.484      (e)          P=0.495      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/47 (19%)   16/49 (33%)  16/50 (32%)  6/49 (12%)  |19/48 (40%)  15/45 (33%)  22/50 (44%)  19/47 (40%)  | 
|POLY-3 RATE (b)    |     9/39.09      16/43.94     16/44.04     6/27.56     |19/42.52     15/39.92     22/46.52     19/43.48     | 
|POLY-3 PERCENT (g) |     23.0%        36.4%        36.3%        21.8%       |44.7%        37.6%        47.3%        43.7%        | 
|TERMINAL (d)       |     8/23 (35%)   10/27 (37%)  9/27 (33%)   0/0 (0%)    |15/30 (50%)  14/31 (45%)  19/38 (50%)  14/31 (45%)  | 
|FIRST INCIDENCE    |     564          456          586          564         |626          585          627          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.162      P=0.165      P=0.007 **  |P=0.407      P=0.229N     P=0.475N     P=0.556N     | 
|POLY 3             |     P=0.329N     P=0.135      P=0.136      P=0.569N    |P=0.502      P=0.331N     P=0.487      P=0.550N     | 
|POLY 1.5           |     P=0.143N     P=0.120      P=0.126      P=0.408N    |P=0.480      P=0.329N     P=0.457      P=0.568N     | 
|POLY 6             |     P=0.429      P=0.164      P=0.155      P=0.405     |P=0.519      P=0.339N     P=0.518      P=0.539N     | 
|LOGISTIC REGRESSION|     P=0.338N     P=0.118      P=0.124      P=0.511     |P=0.457      P=0.327N     P=0.534      P=0.577N     | 
|COCH-ARM / FISHERS |     P=0.039N*    P=0.101      P=0.112      P=0.258N    |P=0.431      P=0.341N     P=0.406      P=0.550      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/39.90      0/40.78      0/42.10      2/25.87     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.7%        |                                                    | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          610         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.030 *   |                                                    | 
|POLY 3             |     P=0.026 *    (e)          (e)          P=0.156     |                                                    | 
|POLY 1.5           |     P=0.032 *    (e)          (e)          P=0.193     |                                                    | 
|POLY 6             |     P=0.021 *    (e)          (e)          P=0.111     |                                                    | 
|LOGISTIC REGRESSION|     P=0.048 *    (e)          (e)          P=0.167     |                                                    | 
|COCH-ARM / FISHERS |     P=0.044 *    (e)          (e)          P=0.247     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/47 (6%)    3/50 (6%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/39.90      3/41.31      3/42.59      1/25.58     |                                                    | 
|POLY-3 PERCENT (g) |     2.5%         7.3%         7.0%         3.9%        |                                                    | 
|TERMINAL (d)       |     1/23 (4%)    2/27 (7%)    2/27 (7%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     729 (T)      564          583          614         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346      P=0.343      P=0.363      P=0.335     |                                                    | 
|POLY 3             |     P=0.593N     P=0.317      P=0.328      P=0.653     |                                                    | 
|POLY 1.5           |     P=0.492N     P=0.304      P=0.321      P=0.710     |                                                    | 
|POLY 6             |     P=0.437      P=0.337      P=0.337      P=0.547     |                                                    | 
|LOGISTIC REGRESSION|     P=0.552N     P=0.296      P=0.320      P=0.610     |                                                    | 
|COCH-ARM / FISHERS |     P=0.378N     P=0.285      P=0.309      P=0.753N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/48 (23%)  11/50 (22%)  10/50 (20%)  5/50 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     11/40.03     11/42.67     10/42.17     5/27.43     |                                                    | 
|POLY-3 PERCENT (g) |     27.5%        25.8%        23.7%        18.2%       |                                                    | 
|TERMINAL (d)       |     8/23 (35%)   10/27 (37%)  9/27 (33%)   0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     323          661          712          561         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.441N     P=0.355N     P=0.040 *   |                                                    | 
|POLY 3             |     P=0.255N     P=0.530N     P=0.445N     P=0.281N    |                                                    | 
|POLY 1.5           |     P=0.129N     P=0.537N     P=0.445N     P=0.152N    |                                                    | 
|POLY 6             |     P=0.497N     P=0.514N     P=0.450N     P=0.567N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.562N     P=0.496N     P=0.408N     P=0.248N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.046N*    P=0.553N     P=0.458N     P=0.072N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/48 (17%)   8/50 (16%)   12/50 (24%)  0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     8/39.25      8/42.58      12/43.99     0/25.17     |                                                    | 
|POLY-3 PERCENT (g) |     20.4%        18.8%        27.3%        0.0%        |                                                    | 
|TERMINAL (d)       |     6/23 (26%)   5/27 (19%)   7/27 (26%)   0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     569          709          564          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.572N     P=0.455N     P=0.344      P=0.574N    |                                                    | 
|POLY 3             |     P=0.057N     P=0.539N     P=0.316      P=0.023N*   |                                                    | 
|POLY 1.5           |     P=0.014N*    P=0.549N     P=0.296      P=0.008N**  |                                                    | 
|POLY 6             |     P=0.272N     P=0.523N     P=0.339      P=0.099N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.067N     P=0.494N     P=0.286      P=0.147N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.572N     P=0.259      P=0.002N**  |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    5/49 (10%)   0/50 (0%)    0/50 (0%)   |3/49 (6%)    4/50 (8%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/38.94      5/41.59      0/42.10      0/25.17     |3/42.42      4/43.04      3/45.88      1/43.89      | 
|POLY-3 PERCENT (g) |     2.6%         12.0%        0.0%         0.0%        |7.1%         9.3%         6.5%         2.3%         | 
|TERMINAL (d)       |     1/23 (4%)    4/27 (15%)   0/27 (0%)    0/0 (0%)    |3/30 (10%)   4/31 (13%)   3/38 (8%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      684          ---          ---         |729 (T)      729 (T)      729 (T)      668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.538N     P=0.144      P=0.468N     P=1.000N    |P=0.166N     P=0.518      P=0.550N     P=0.300N     | 
|POLY 3             |     P=0.129N     P=0.116      P=0.484N     P=0.583N    |P=0.163N     P=0.508      P=0.626N     P=0.293N     | 
|POLY 1.5           |     P=0.109N     P=0.110      P=0.488N     P=0.540N    |P=0.162N     P=0.511      P=0.636N     P=0.293N     | 
|POLY 6             |     P=0.134N     P=0.124      P=0.481N     P=0.651N    |P=0.166N     P=0.503      P=0.615N     P=0.296N     | 
|LOGISTIC REGRESSION|     P=0.390N     P=0.140      (e)          (e)         |P=0.169N     P=0.518      P=0.550N     P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.089N     P=0.102      P=0.495N     P=0.495N    |P=0.165N     P=0.511      P=0.651N     P=0.301N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    1/50 (2%)    0/50 (0%)   |1/49 (2%)    3/50 (6%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/38.94      1/41.42      1/42.10      0/25.17     |1/42.42      3/43.04      5/45.88      0/43.66      | 
|POLY-3 PERCENT (g) |     2.6%         2.4%         2.4%         0.0%        |2.4%         7.0%         10.9%        0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    1/27 (4%)    1/27 (4%)    0/0 (0%)    |1/30 (3%)    3/31 (10%)   5/38 (13%)   0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.976N     P=0.726N     P=0.726N     P=1.000N    |P=0.159N     P=0.316      P=0.163      P=0.493N     | 
|POLY 3             |     P=0.428N     P=0.747N     P=0.743N     P=0.583N    |P=0.155N     P=0.310      P=0.120      P=0.494N     | 
|POLY 1.5           |     P=0.384N     P=0.752N     P=0.747N     P=0.540N    |P=0.154N     P=0.312      P=0.115      P=0.493N     | 
|POLY 6             |     P=0.472N     P=0.740N     P=0.739N     P=0.651N    |P=0.160N     P=0.306      P=0.126      P=0.497N     | 
|LOGISTIC REGRESSION|     P=0.976N     P=0.726N     P=0.726N     (e)         |P=0.159N     P=0.316      P=0.163      (e)          | 
|COCH-ARM / FISHERS |     P=0.328N     P=0.753N     P=0.747N     P=0.495N    |P=0.162N     P=0.316      P=0.107      P=0.495N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/50 (0%)    22/50 (44%) |0/49 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/38.94      1/41.59      0/42.10      22/35.70    |0/42.42      1/43.52      1/46.11      1/43.71      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         61.6%       |0.0%         2.3%         2.2%         2.3%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          684          ---          431         |---          585          667          718          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.536      (e)          P<0.001 **  |P=0.522      P=0.509      P=0.515      P=0.506      | 
|POLY 3             |     P<0.001 **   P=0.513      (e)          P<0.001 **  |P=0.533      P=0.505      P=0.517      P=0.506      | 
|POLY 1.5           |     P<0.001 **   P=0.508      (e)          P<0.001 **  |P=0.534      P=0.505      P=0.512      P=0.507      | 
|POLY 6             |     P<0.001 **   P=0.521      (e)          P<0.001 **  |P=0.528      P=0.505      P=0.522      P=0.503      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.506      (e)          P<0.001 **  |P=0.513      P=0.479      P=0.491      P=0.502      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      (e)          P<0.001 **  |P=0.530      P=0.505      P=0.505      P=0.505      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    2/48 (4%)    0/49 (0%)    0/46 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/35.63      2/41.09      0/42.00      0/23.53     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.9%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          716          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.969N     P=0.295      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.423N     P=0.269      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.414N     P=0.266      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.395N     P=0.274      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.840N     P=0.280      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.388N     P=0.275      (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    4/48 (8%)    0/49 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/39.34      4/40.49      0/41.10      0/24.65     |0/43.16      0/43.04      0/45.88      0/43.66      | 
|POLY-3 PERCENT (g) |     2.5%         9.9%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    3/25 (12%)   0/26 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      709          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.633N     P=0.219      P=0.476N     P=1.000     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.172N     P=0.186      P=0.491N     P=0.589N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.150N     P=0.183      P=0.493N     P=0.544N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.174N     P=0.193      P=0.490N     P=0.655N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.547N     P=0.220      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.121N     P=0.181      P=0.495N     P=0.495N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/48 (2%)    0/49 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/39.39      1/40.46      0/41.10      0/24.65     |0/43.16      0/43.04      0/45.88      2/43.66      | 
|POLY-3 PERCENT (g) |     2.5%         2.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/23 (0%)    0/25 (0%)    0/26 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    2/31 (7%)    | 
|FIRST INCIDENCE    |     718          717          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.926N     P=0.711N     P=0.455N     P=1.000N    |P=0.038 *    (e)          (e)          P=0.245      | 
|POLY 3             |     P=0.370N     P=0.755N     P=0.491N     P=0.589N    |P=0.041 *    (e)          (e)          P=0.240      | 
|POLY 1.5           |     P=0.367N     P=0.757N     P=0.493N     P=0.544N    |P=0.042 *    (e)          (e)          P=0.240      | 
|POLY 6             |     P=0.324N     P=0.750N     P=0.490N     P=0.655N    |P=0.041 *    (e)          (e)          P=0.237      | 
|LOGISTIC REGRESSION|     P=0.722N     P=0.746N     P=0.486N     P=0.994N    |(e)          (e)          (e)          P=0.245      | 
|COCH-ARM / FISHERS |     P=0.345N     P=0.753N     P=0.495N     P=0.495N    |P=0.042 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/43 (14%)   5/50 (10%)   4/49 (8%)    2/47 (4%)   |0/48 (0%)    0/48 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     6/37.67      5/42.93      4/42.97      2/24.16     |0/41.44      0/41.12      0/45.12      0/42.76      | 
|POLY-3 PERCENT (g) |     15.9%        11.7%        9.3%         8.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    2/27 (7%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     564          661          586          629         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319      P=0.407N     P=0.315N     P=0.332     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.297N     P=0.408N     P=0.288N     P=0.322N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.202N     P=0.400N     P=0.284N     P=0.197N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.414N     P=0.414N     P=0.297N     P=0.558N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.153N     P=0.396N     P=0.323N     P=0.232N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.109N     P=0.393N     P=0.289N     P=0.106N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/43 (5%)    5/50 (10%)   2/49 (4%)    0/47 (0%)   |7/48 (15%)   7/48 (15%)   4/49 (8%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     2/36.86      5/44.83      2/42.90      0/23.65     |7/44.73      7/42.06      4/45.93      2/43.49      | 
|POLY-3 PERCENT (g) |     5.4%         11.2%        4.7%         0.0%        |15.7%        16.6%        8.7%         4.6%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |1/30 (3%)    2/31 (7%)    1/38 (3%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     564          456          564          ---         |247          626          604          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164N     P=0.255      P=0.673N     P=0.566N    |P=0.060N     P=0.606      P=0.220N     P=0.091N     | 
|POLY 3             |     P=0.156N     P=0.301      P=0.639N     P=0.347N    |P=0.052N     P=0.566      P=0.246N     P=0.085N     | 
|POLY 1.5           |     P=0.107N     P=0.295      P=0.639N     P=0.279N    |P=0.051N     P=0.584      P=0.249N     P=0.082N     | 
|POLY 6             |     P=0.229N     P=0.311      P=0.642N     P=0.468N    |P=0.055N     P=0.546      P=0.242N     P=0.091N     | 
|LOGISTIC REGRESSION|     P=0.011N*    P=0.221      P=0.667      P=0.196N    |P=0.081N     P=0.605      P=0.388N     P=0.174N     | 
|COCH-ARM / FISHERS |     P=0.062N     P=0.285      P=0.641N     P=0.225N    |P=0.052N     P=0.613N     P=0.250N     P=0.079N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/43 (5%)    0/50 (0%)    0/49 (0%)    0/47 (0%)   |1/48 (2%)    0/48 (0%)    0/49 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     2/36.72      0/42.41      0/42.00      0/23.65     |1/41.44      0/41.12      0/45.12      1/43.03      | 
|POLY-3 PERCENT (g) |     5.5%         0.0%         0.0%         0.0%        |2.4%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/23 (4%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |1/30 (3%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     568          ---          ---          ---         |729 (T)      ---          ---          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.494N     P=0.222N     P=0.213N     P=0.574N    |P=0.521      P=0.493N     P=0.453N     P=0.757N     | 
|POLY 3             |     P=0.302N     P=0.205N     P=0.207N     P=0.346N    |P=0.529      P=0.502N     P=0.483N     P=0.752N     | 
|POLY 1.5           |     P=0.314N     P=0.204N     P=0.206N     P=0.278N    |P=0.527      P=0.500N     P=0.488N     P=0.754N     | 
|POLY 6             |     P=0.230N     P=0.205N     P=0.210N     P=0.466N    |P=0.530      P=0.503N     P=0.478N     P=0.752N     | 
|LOGISTIC REGRESSION|     P=0.266N     P=0.210N     P=0.225N     P=0.242N    |P=0.523      (e)          (e)          P=0.761N     | 
|COCH-ARM / FISHERS |     P=0.305N     P=0.211N     P=0.216N     P=0.225N    |P=0.522      P=0.500N     P=0.495N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Focal Lymphoid                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/43 (9%)    4/50 (8%)    9/49 (18%)   2/47 (4%)   |0/48 (0%)    0/48 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     4/36.20      4/42.42      9/42.00      2/24.47     |0/41.44      0/41.12      0/45.12      0/42.76      | 
|POLY-3 PERCENT (g) |     11.1%        9.4%         21.4%        8.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/23 (17%)   3/27 (11%)   9/27 (33%)   0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      728          729 (T)      564         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.551N     P=0.172      P=0.044 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.559N     P=0.554N     P=0.176      P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.372N     P=0.554N     P=0.179      P=0.410N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.283      P=0.551N     P=0.169      P=0.608     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.055      (e)          P=0.172      P=0.511     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.197N     P=0.555N     P=0.173      P=0.297N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    0/50 (0%)    0/49 (0%)    0/47 (0%)   |0/48 (0%)    1/48 (2%)    1/49 (2%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/36.20      0/42.41      0/42.00      0/23.65     |0/41.44      1/41.12      1/45.12      3/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.4%         2.2%         7.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    1/38 (3%)    3/31 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.064      P=0.507      P=0.547      P=0.126      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.073      P=0.498      P=0.517      P=0.124      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.072      P=0.500      P=0.512      P=0.123      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.072      P=0.497      P=0.522      P=0.123      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.507      P=0.547      P=0.126      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.069      P=0.500      P=0.505      P=0.121      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/43 (0%)    3/50 (6%)    2/49 (4%)    0/47 (0%)   |1/48 (2%)    1/48 (2%)    1/49 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/36.20      3/42.99      2/42.18      0/23.65     |1/41.90      1/41.46      1/45.48      0/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         7.0%         4.7%         0.0%        |2.4%         2.4%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    1/27 (4%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          614          682          ---         |596          634          627          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.815      P=0.150      P=0.268      (e)         |P=0.334N     P=0.758      P=0.735N     P=0.500N     | 
|POLY 3             |     P=0.424N     P=0.151      P=0.272      (e)         |P=0.331N     P=0.758      P=0.742N     P=0.496N     | 
|POLY 1.5           |     P=0.338N     P=0.150      P=0.271      (e)         |P=0.330N     P=0.760      P=0.747N     P=0.496N     | 
|POLY 6             |     P=0.556N     P=0.154      P=0.270      (e)         |P=0.334N     P=0.756      P=0.736N     P=0.498N     | 
|LOGISTIC REGRESSION|     P=0.392N     P=0.148      P=0.270      (e)         |P=0.383N     P=0.752      P=0.731      P=0.577N     | 
|COCH-ARM / FISHERS |     P=0.251N     P=0.151      P=0.281      (e)         |P=0.333N     P=0.753N     P=0.747N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    5/49 (10%)  |4/50 (8%)    3/49 (6%)    3/50 (6%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     0/39.90      1/42.59      3/42.52      5/27.30     |4/44.59      3/43.03      3/46.06      2/42.80      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         7.1%         18.3%       |9.0%         7.0%         6.5%         4.7%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    1/27 (4%)    0/0 (0%)    |1/30 (3%)    1/31 (3%)    2/38 (5%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          684          649          431         |413          585          681          626          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.536      P=0.142      P=0.011 *   |P=0.327N     P=0.485N     P=0.423N     P=0.332N     | 
|POLY 3             |     P=0.003 **   P=0.513      P=0.130      P=0.009 **  |P=0.336N     P=0.519N     P=0.482N     P=0.356N     | 
|POLY 1.5           |     P=0.007 **   P=0.508      P=0.126      P=0.017 *   |P=0.335N     P=0.516N     P=0.489N     P=0.354N     | 
|POLY 6             |     P<0.001 **   P=0.521      P=0.134      P=0.004 **  |P=0.340N     P=0.522N     P=0.473N     P=0.359N     | 
|LOGISTIC REGRESSION|     P=0.037 *    P=0.505      P=0.127      P=0.062     |P=0.382N     P=0.535N     P=0.558N     P=0.438N     | 
|COCH-ARM / FISHERS |     P=0.015 *    P=0.500      P=0.121      P=0.027 *   |P=0.337N     P=0.511N     P=0.500N     P=0.359N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia Basal Cell                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/49 (4%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/39.90      0/42.41      1/42.29      2/25.24     |0/43.16      0/42.07      0/45.88      0/42.42      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         7.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          682          614         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P=0.519      P=0.019 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.044 *    (e)          P=0.512      P=0.152     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.063      (e)          P=0.508      P=0.188     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.024 *    (e)          P=0.516      P=0.108     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.056      (e)          P=0.505      P=0.124     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.093      (e)          P=0.500      P=0.242     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia Diffuse                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    1/49 (2%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     2/40.31      0/42.41      1/42.65      1/25.10     |0/43.16      0/42.07      0/45.88      0/42.42      | 
|POLY-3 PERCENT (g) |     5.0%         0.0%         2.3%         4.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     653          ---          562          589         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.426      P=0.216N     P=0.493N     P=0.485     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.563      P=0.226N     P=0.480N     P=0.656N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.630      P=0.229N     P=0.486N     P=0.583N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.469      P=0.220N     P=0.475N     P=0.654     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.590N     P=0.235N     P=0.530N     P=0.648N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.661N     P=0.247N     P=0.500N     P=0.508N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   8/50 (16%)   10/49 (20%) |2/50 (4%)    6/49 (12%)   2/50 (4%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     3/40.61      5/43.83      8/44.67      10/28.71    |2/43.62      6/44.13      2/46.69      1/42.92      | 
|POLY-3 PERCENT (g) |     7.4%         11.4%        17.9%        34.8%       |4.6%         13.6%        4.3%         2.3%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     645          550          562          564         |624          435          597          577          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.430      P=0.141      P<0.001 **  |P=0.153N     P=0.143      P=0.648N     P=0.497N     | 
|POLY 3             |     P=0.003 **   P=0.398      P=0.129      P=0.004 **  |P=0.148N     P=0.136      P=0.669N     P=0.506N     | 
|POLY 1.5           |     P=0.009 **   P=0.383      P=0.118      P=0.012 *   |P=0.148N     P=0.133      P=0.678N     P=0.507N     | 
|POLY 6             |     P<0.001 **   P=0.422      P=0.144      P<0.001 **  |P=0.151N     P=0.140      P=0.658N     P=0.507N     | 
|LOGISTIC REGRESSION|     P=0.064      P=0.333      P=0.078      P=0.014 *   |P=0.202N     P=0.116      P=0.653      P=0.568N     | 
|COCH-ARM / FISHERS |     P=0.032 *    P=0.357      P=0.100      P=0.033 *   |P=0.154N     P=0.128      P=0.691N     P=0.515N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    1/49 (2%)    0/50 (0%)    2/48 (4%)   |1/49 (2%)    1/47 (2%)    0/49 (0%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     0/38.21      1/41.98      0/42.10      2/25.87     |1/42.88      1/40.49      0/45.32      1/42.03      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         7.7%        |2.3%         2.5%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    1/31 (3%)    | 
|FIRST INCIDENCE    |     ---          726          ---          398         |596          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055      P=0.546      (e)          P=0.249     |P=0.668      P=0.759N     P=0.479N     P=0.757N     | 
|POLY 3             |     P=0.100      P=0.519      (e)          P=0.163     |P=0.665      P=0.748      P=0.489N     P=0.756      | 
|POLY 1.5           |     P=0.121      P=0.516      (e)          P=0.200     |P=0.665      P=0.750      P=0.493N     P=0.756      | 
|POLY 6             |     P=0.082      P=0.524      (e)          P=0.116     |P=0.663      P=0.745      P=0.485N     P=0.755      | 
|LOGISTIC REGRESSION|     P=0.377      P=0.544      (e)          P=0.214     |P=0.658      P=0.752      P=0.544N     P=0.739      | 
|COCH-ARM / FISHERS |     P=0.152      P=0.516      (e)          P=0.258     |P=0.662      P=0.742      P=0.500N     P=0.742      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/46 (11%)   7/49 (14%)   2/50 (4%)    5/48 (10%)  |3/49 (6%)    2/47 (4%)    2/49 (4%)    4/47 (9%)    | 
|POLY-3 RATE (b)    |     5/40.25      7/43.16      2/42.77      5/26.55     |3/42.98      2/40.86      2/45.89      4/43.52      | 
|POLY-3 PERCENT (g) |     12.4%        16.2%        4.7%         18.8%       |7.0%         4.9%         4.4%         9.2%         | 
|TERMINAL (d)       |     0/23 (0%)    0/27 (0%)    0/27 (0%)    0/0 (0%)    |0/30 (0%)    0/31 (0%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     323          614          584          431         |596          680          638          564          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.481      P=0.202N     P=0.082     |P=0.304      P=0.509N     P=0.439N     P=0.503      | 
|POLY 3             |     P=0.414      P=0.428      P=0.190N     P=0.361     |P=0.319      P=0.523N     P=0.470N     P=0.507      | 
|POLY 1.5           |     P=0.521      P=0.424      P=0.188N     P=0.502     |P=0.312      P=0.520N     P=0.481N     P=0.498      | 
|POLY 6             |     P=0.307      P=0.444      P=0.194N     P=0.182     |P=0.324      P=0.526N     P=0.457N     P=0.514      | 
|LOGISTIC REGRESSION|     P=0.267N     P=0.389      P=0.213N     P=0.343N    |P=0.241      P=0.520N     P=0.534N     P=0.395      | 
|COCH-ARM / FISHERS |     P=0.513N     P=0.425      P=0.185N     P=0.602N    |P=0.295      P=0.520N     P=0.500N     P=0.476      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    1/50 (2%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     2/40.02      4/43.17      1/42.47      3/26.78     |                                                    | 
|POLY-3 PERCENT (g) |     5.0%         9.3%         2.4%         11.2%       |                                                    | 
|TERMINAL (d)       |     1/23 (4%)    3/27 (11%)   0/27 (0%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     698          456          627          431         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.052      P=0.412      P=0.462N     P=0.049 *   |                                                    | 
|POLY 3             |     P=0.376      P=0.372      P=0.479N     P=0.325     |                                                    | 
|POLY 1.5           |     P=0.452      P=0.360      P=0.486N     P=0.411     |                                                    | 
|POLY 6             |     P=0.299      P=0.389      P=0.472N     P=0.204     |                                                    | 
|LOGISTIC REGRESSION|     P=0.624N     P=0.343      P=0.490N     P=0.498     |                                                    | 
|COCH-ARM / FISHERS |     P=0.551      P=0.339      P=0.500N     P=0.500     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     3/40.56      2/43.17      2/42.47      1/25.54     |                                                    | 
|POLY-3 PERCENT (g) |     7.4%         4.6%         4.7%         3.9%        |                                                    | 
|TERMINAL (d)       |     1/23 (4%)    1/27 (4%)    1/27 (4%)    0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     565          456          627          627         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.586      P=0.449N     P=0.452N     P=0.586     |                                                    | 
|POLY 3             |     P=0.453N     P=0.472N     P=0.479N     P=0.482N    |                                                    | 
|POLY 1.5           |     P=0.378N     P=0.481N     P=0.485N     P=0.390N    |                                                    | 
|POLY 6             |     P=0.529N     P=0.458N     P=0.473N     P=0.631N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.250N     P=0.540N     P=0.502N     P=0.474N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.286N     P=0.500N     P=0.500N     P=0.309N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/42 (57%)  26/47 (55%)  31/48 (65%)  3/47 (6%)   |36/45 (80%)  36/45 (80%)  38/46 (83%)  28/46 (61%)  | 
|POLY-3 RATE (b)    |     24/38.21     26/41.87     31/45.04     3/24.78     |36/42.95     36/42.33     38/45.12     28/43.74     | 
|POLY-3 PERCENT (g) |     62.8%        62.1%        68.8%        12.1%       |83.8%        85.1%        84.2%        64.0%        | 
|TERMINAL (d)       |     16/23 (70%)  21/27 (78%)  19/27 (70%)  0/0 (0%)    |25/30 (83%)  29/31 (94%)  32/38 (84%)  21/31 (68%)  | 
|FIRST INCIDENCE    |     564          456          543          610         |413          542          597          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.300      P=0.454N     P=0.330      P=0.367     |P=0.038N*    P=0.518N     P=0.186N     P=0.080N     | 
|POLY 3             |     P<0.001N**   P=0.568N     P=0.360      P<0.001N**  |P=0.003N**   P=0.559      P=0.597      P=0.026N*    | 
|POLY 1.5           |     P<0.001N**   P=0.544N     P=0.340      P<0.001N**  |P=0.004N**   P=0.591      P=0.569      P=0.026N*    | 
|POLY 6             |     P=0.027N*    P=0.599N     P=0.387      P=0.005N**  |P=0.003N**   P=0.517      P=0.616      P=0.030N*    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.521N     P=0.329      P=0.007N**  |P=0.005N**   P=0.568N     P=0.565N     P=0.029N*    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.516N     P=0.306      P<0.001N**  |P=0.008N**   P=0.604N     P=0.480      P=0.038N*    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  02/04/02                           EXPERIMENT: 88031 TEST: 05                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                    DIPROPYLENE GLYCOL                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/42 (2%)    1/47 (2%)    1/48 (2%)    2/47 (4%)   |0/45 (0%)    1/45 (2%)    0/46 (0%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     1/35.67      1/40.06      1/41.38      2/24.68     |0/39.48      1/39.80      0/43.82      0/41.10      | 
|POLY-3 PERCENT (g) |     2.8%         2.5%         2.4%         8.1%        |0.0%         2.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/23 (4%)    1/27 (4%)    1/27 (4%)    0/0 (0%)    |0/30 (0%)    1/31 (3%)    0/38 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      574         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.726N     P=0.726N     P=0.070     |P=0.612N     P=0.507      (e)          (e)          | 
|POLY 3             |     P=0.244      P=0.735N     P=0.728N     P=0.376     |P=0.609N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.303      P=0.736N     P=0.728N     P=0.453     |P=0.607N     P=0.502      (e)          (e)          | 
|POLY 6             |     P=0.180      P=0.732N     P=0.727N     P=0.268     |P=0.612N     P=0.501      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.200      P=0.726N     P=0.726N     P=0.419     |(e)          P=0.507      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.386      P=0.724N     P=0.718N     P=0.543     |P=0.605N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0.0%         0.25%        1.0%         4.0%        |0.0%         0.25%        1.0%         4.0%         | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     3/3 (100%)   0/0 (0%)    |6/6 (100%)   2/2 (100%)   1/1 (100%)   1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       0/0.00       3/3.00       0/0.00      |6/6.00       2/2.00       1/1.00       1/1.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       0.0%        |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     3/3 (100%)   0/0 (0%)    |3/3 (100%)   1/1 (100%)   1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |247          683          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
                                                                                                                                   
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).