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TDMS Study 88031-06 Pathology Tables

NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01
Route: DOSED WATER                                                                                                Time: 14:32:26

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  25265-71-8

       Lock Date:  04/20/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11           11            8            7                                     
    Moribund Sacrifice                                 2            1            4            6                                     
    Accidently Killed                                                                         4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           38           38           32                                     
    Natural Death                                                                             1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (49)                                   
      Ulcer                                                                                   1 (2%)                                
   Gallbladder                                        (50)         (50)         (49)         (50)                                   
      Epithelium, Cyst                                 5 (10%)      1 (2%)       1 (2%)       1 (2%)                                
      Epithelium, Cytoplasmic Alteration               1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
      Muscularis, Inflammation, Chronic                                          1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                                       2 (4%)       2 (4%)                                
      Peyer's Patch, Inflammation, Acute               1 (2%)                                 1 (2%)                                
      Serosa, Fibrosis                                                           1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
      Epithelium, Inflammation, Chronic                                          1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Angiectasis, Focal                               3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Basophilic Focus                                 2 (4%)                    1 (2%)       1 (2%)                                
      Clear Cell Focus                                 5 (10%)      5 (10%)      2 (4%)       8 (16%)                               
      Eosinophilic Focus                              21 (42%)     13 (26%)     16 (32%)     17 (34%)                               
      Hepatodiaphragmatic Nodule                                                              1 (2%)                                
      Infiltration Cellular, Lymphocyte               30 (60%)     39 (78%)     35 (70%)     30 (60%)                               
      Inflammation, Chronic                           36 (72%)     33 (66%)     35 (70%)     34 (68%)                               
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Mixed Cell Focus                                14 (28%)     19 (38%)     21 (42%)     15 (30%)                               
      Necrosis, Focal                                  2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 4 (8%)      10 (20%)      9 (18%)     10 (20%)                               
      Sinusoid, Amyloid Deposition                                               1 (2%)                                             
   Mesentery                                          (11)         (18)         (13)         (14)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic                                                           1 (7%)                                
      Fat, Necrosis                                   11 (100%)    13 (72%)     11 (85%)     13 (93%)                               
      Vein, Thrombosis                                              1 (6%)                                                          
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Granulomatous                                                1 (2%)                                             
      Acinus, Atrophy                                                            1 (2%)       1 (2%)                                
      Acinus, Vacuolization Cytoplasmic, Focal         1 (2%)                                                                       
      Duct, Cyst                                                                              1 (2%)                                
   Salivary Glands                                    (49)         (49)         (49)         (49)                                   
      Atrophy                                                                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Squamous                            4 (8%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Focal, Suppurative                                                        1 (2%)                                
      Ulcer                                            3 (6%)                    1 (2%)       1 (2%)                                
      Epithelium, Cyst                                                           1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization, Focal                            4 (8%)       2 (4%)       5 (10%)                                            
      Ulcer                                                         1 (2%)                    2 (4%)                                
   Tooth                                                                                     (1)                                    
      Malformation                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Inflammation, Chronic                                                            2 (4%)                                
      Aorta, Mineralization                            1 (2%)       3 (6%)                                                          
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   1 (2%)                                                                       
      Artery, Inflammation, Chronic                    1 (2%)                                 1 (2%)                                
      Epicardium, Inflammation, Chronic Active                      1 (2%)                                                          
      Myocardium, Inflammation, Chronic Active,                                                                                     
           Focal                                       2 (4%)                                 1 (2%)                                
      Myocardium, Mineralization                       2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Valve, Inflammation, Chronic                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Hypertrophy, Focal                               3 (6%)       3 (6%)       2 (4%)       1 (2%)                                
      Subcapsular, Hyperplasia                        48 (96%)     49 (98%)     49 (100%)    48 (96%)                               
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     31 (62%)     29 (58%)     29 (58%)     33 (66%)                               
   Pituitary Gland                                    (49)         (49)         (49)         (49)                                   
      Angiectasis                                      1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                6 (12%)      8 (16%)      6 (12%)      5 (10%)                               
   Thyroid Gland                                      (49)         (48)         (49)         (48)                                   
      Inflammation, Granulomatous                      1 (2%)       1 (2%)                    2 (4%)                                
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (49)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      3 (6%)                    5 (10%)      2 (4%)                                
      Cyst                                            12 (24%)     11 (22%)     15 (30%)     14 (28%)                               
      Hemorrhage                                       2 (4%)                                                                       
      Periovarian Tissue, Infiltration Cellular,                                                                                    
           Lymphocyte                                               1 (2%)                                                          
   Oviduct                                                                                   (1)                                    
      Cyst                                                                                    1 (100%)                              
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                38 (76%)     38 (76%)     39 (78%)     39 (78%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
      Fibrosis                                                      1 (2%)                                                          
      Necrosis, Acute, Focal                           1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
   Lymph Node                                         (5)          (3)          (1)          (2)                                    
      Lumbar, Hematopoietic Cell Proliferation         1 (20%)                                                                      
      Lumbar, Infiltration Cellular, Plasma Cell       2 (40%)                                                                      
      Lumbar, Infiltration Cellular, Histiocyte        1 (20%)                                                                      
      Mediastinal, Congestion                                                    1 (100%)                                           
      Mediastinal, Hyperplasia, Lymphoid                                         1 (100%)                                           
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (20%)                                                                      
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (20%)                                                                      
      Mediastinal, Pigmentation, Hemosiderin           1 (20%)                                                                      
      Pancreatic, Inflammation, Granulomatous                                    1 (100%)                                           
      Renal, Hyperplasia, Lymphoid                                               1 (100%)                                           
   Lymph Node, Mandibular                             (48)         (45)         (48)         (48)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (48)         (49)         (49)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                    2 (4%)                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                29 (58%)     24 (48%)     25 (50%)     24 (48%)                               
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Capsule, Fibrosis, Focal                                                   1 (2%)                                             
      Lymphoid Follicle, Amyloid Deposition                                      1 (2%)                                             
      Lymphoid Follicle, Atrophy                      12 (24%)     10 (20%)     10 (20%)     12 (24%)                               
      Lymphoid Follicle, Hyperplasia                   7 (14%)      8 (16%)      6 (12%)      7 (14%)                               
   Thymus                                             (49)         (49)         (48)         (50)                                   
      Hyperplasia, Lymphoid                            5 (10%)      1 (2%)       4 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Duct, Hyperplasia, Squamous                      1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                                                      1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Epidermis, Cyst                                                            1 (2%)                                             
      Epidermis, Hyperplasia, Focal                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrosis                                         4 (8%)       4 (8%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (50)                                   
      Hydrocephalus                                                                           2 (4%)                                
      Necrosis, Acute, Focal                                                     1 (2%)                                             
      Artery, Meninges, Inflammation, Chronic                                                 1 (2%)                                
      Hypothalamus, Compression                                     1 (2%)                    2 (4%)                                
   Peripheral Nerve                                   (1)                                                                           
      Sciatic, Axon, Degeneration                      1 (100%)                                                                     
   Spinal Cord                                        (1)                                                                           
      Axon, Degeneration                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Hemorrhage, Focal                                1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                     3 (6%)       2 (4%)       4 (8%)       2 (4%)                                
      Inflammation, Granulomatous                      1 (2%)       3 (6%)                    2 (4%)                                
      Thrombosis                                       3 (6%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Artery, Mineralization                                        1 (2%)                                                          
      Bronchus, Foreign Body                                                                  4 (8%)                                
      Bronchus, Inflammation, Acute                    1 (2%)                                 4 (8%)                                
   Nose                                               (50)         (49)         (50)         (50)                                   
      Inflammation, Acute                                                                     3 (6%)                                
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Glands, Cyst                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (2)                                    
      Atrophy                                                                                 1 (50%)                               
      Degeneration                                                                            1 (50%)                               
      Cornea, Inflammation, Chronic                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                             2 (4%)                                             
      Infarct                                          4 (8%)       7 (14%)      9 (18%)      8 (16%)                               
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)       3 (6%)                                                          
      Nephropathy                                     12 (24%)      8 (16%)     15 (30%)     12 (24%)                               
      Artery, Inflammation, Chronic                    1 (2%)                    1 (2%)                                             
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                              1 (2%)                                                          
      Renal Tubule, Vacuolization Cytoplasmic                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (49)         (49)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            8           10            6                                     
    Moribund Sacrifice                                 3            3            5            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           39           35           34                                     
    Natural Death                                      1                                                                            
  Missing                                                                                     1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Gallbladder                                        (48)         (48)         (49)         (48)                                   
      Epithelium, Cyst                                              1 (2%)                    2 (4%)                                
      Epithelium, Cytoplasmic Alteration               2 (4%)       1 (2%)                                                          
      Epithelium, Mineralization                                                 1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Serosa, Inflammation, Granulomatous                           1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Intestine Large, Cecum                             (50)         (50)         (50)         (49)                                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (49)         (50)         (49)                                   
      Cyst                                                                                    1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                                             1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)       3 (6%)                                             
      Peyer's Patch, Infiltration Cellular, Plasma                                                                                  
          Cell                                                                   1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (49)                                   
      Angiectasis, Focal                                                         2 (4%)       1 (2%)                                
      Basophilic Focus                                 2 (4%)       1 (2%)                    3 (6%)                                
      Clear Cell Focus                                26 (52%)     24 (48%)     31 (62%)     12 (24%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Eosinophilic Focus                              15 (30%)     28 (56%)     18 (36%)     11 (22%)                               
      Fibrosis, Focal                                                            1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Chronic                           23 (46%)     21 (42%)     20 (40%)     20 (41%)                               
      Mixed Cell Focus                                15 (30%)     20 (40%)     21 (42%)      7 (14%)                               
      Necrosis, Focal                                  7 (14%)      5 (10%)      5 (10%)      5 (10%)                               
      Vacuolization Cytoplasmic, Focal                 3 (6%)       3 (6%)       4 (8%)       2 (4%)                                
      Serosa, Fibrosis                                                                        1 (2%)                                
   Mesentery                                          (8)          (10)         (1)                                                 
      Artery, Inflammation, Chronic                                 1 (10%)                                                         
      Fat, Necrosis                                    7 (88%)      9 (90%)      1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Acinus, Atrophy, Focal                           1 (2%)                                                                       
      Duct, Cyst                                                                              1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Atrophy, Focal                                                                          1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Hyperplasia, Squamous                            2 (4%)                    1 (2%)       3 (6%)                                
      Inflammation, Focal, Suppurative                 2 (4%)                                                                       
      Ulcer                                                                      2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic                            3 (6%)                                                                       
      Mineralization, Focal                                         3 (6%)                    2 (4%)                                
      Epithelium, Hyperplasia, Focal                                             2 (4%)                                             
      Epithelium, Inflammation, Focal, Suppurative                  1 (2%)                                                          
   Tooth                                              (26)         (22)         (20)         (7)                                    
      Malformation                                    26 (100%)    22 (100%)    20 (100%)     7 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
      Aorta, Inflammation, Chronic                     1 (2%)                                                                       
      Pulmonary Artery, Mineralization                              1 (2%)                                                          
   Heart                                              (50)         (50)         (50)         (49)                                   
      Cardiomyopathy                                   3 (6%)                    1 (2%)                                             
      Artery, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
      Myocardium, Inflammation, Chronic Active,                                                                                     
           Focal                                       2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Myocardium, Mineralization                       2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal                               7 (14%)      4 (8%)       1 (2%)                                             
      Hypertrophy, Focal                              28 (56%)     24 (48%)     23 (46%)     15 (31%)                               
      Necrosis                                                                   1 (2%)                                             
      Subcapsular, Hyperplasia                        47 (94%)     46 (92%)     44 (88%)     42 (86%)                               
      Zona Fasciculata, Zona Reticularis,                                                                                           
          Vacuolization Cytoplasmic                    1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)         (49)                                   
      Hyperplasia, Focal                                            2 (4%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                     40 (80%)     41 (82%)     39 (78%)     43 (88%)                               
   Pituitary Gland                                    (49)         (48)         (49)         (49)                                   
      Pars Distalis, Hyperplasia, Focal                3 (6%)       3 (6%)       2 (4%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Follicle, Cyst                                   1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (49)                                   
      Atrophy                                                                                 1 (2%)                                
      Granuloma Sperm                                  2 (4%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Syncytial Alteration                             1 (2%)                                                                       
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                            30 (60%)     32 (64%)     34 (68%)     34 (69%)                               
      Cytoplasmic Alteration                                                     1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                 2 (4%)                                
      Inflammation, Suppurative                        5 (10%)      3 (6%)                                                          
      Bilateral, Cyst                                  1 (2%)                                                                       
   Prostate, NOS                                      (50)         (50)         (50)         (49)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                                                                 1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                                                                 2 (4%)                                
      Cyst                                                          4 (8%)                    1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (49)                                   
      Inflammation, Granulomatous                                                1 (2%)                                             
      Germinal Epithelium, Atrophy                                                            1 (2%)                                
      Interstitial Cell, Hyperplasia, Focal            1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (47)         (49)         (48)         (47)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Megakaryocyte             1 (2%)                                                                       
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Lymph Node, Mesenteric                             (48)         (50)         (49)         (48)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Plasma Cell                            1 (2%)                    1 (2%)                                
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hematopoietic Cell Proliferation                15 (30%)     17 (34%)     14 (28%)     12 (24%)                               
      Lymphoid Follicle, Atrophy                      11 (22%)     12 (24%)     11 (22%)     13 (27%)                               
      Lymphoid Follicle, Hyperplasia                   2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
   Thymus                                             (46)         (45)         (47)         (44)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (49)                                   
      Hyperkeratosis                                                                          1 (2%)                                
      Ulcer                                                         1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
   Bone                                               (49)         (50)         (50)         (49)                                   
      Fibrosis                                         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (49)                                   
      Hemorrhage                                                    1 (2%)                                                          
   Peripheral Nerve                                                                          (1)                                    
      Axon, Degeneration                                                                      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Inflammation, Chronic, Focal                                  1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)       1 (2%)                                
      Metaplasia, Focal, Osseous                                                 2 (4%)       1 (2%)                                
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          3 (6%)       3 (6%)       4 (8%)       3 (6%)                                
      Artery, Mineralization                                                                  1 (2%)                                
   Nose                                               (50)         (50)         (50)         (49)                                   
      Hyperostosis                                     1 (2%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (2)          (1)                                                 
      Cornea, Degeneration                                          1 (50%)                                                         
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
      Cornea, Inflammation, Suppurative                             1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Glomerulosclerosis                                                         1 (2%)                                             
      Hydronephrosis                                                2 (4%)       1 (2%)                                             
      Infarct                                          7 (14%)     14 (28%)     10 (20%)      9 (18%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic, Focal                                               1 (2%)       1 (2%)                                
      Metaplasia, Osseous                              3 (6%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 88031-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                         DIPROPYLENE GLYCOL                                    Date: 09/26/01    
Route: DOSED WATER                                                                                                Time: 14:32:26    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0%         1.0%         2.0%         4.0%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy                                     38 (76%)     37 (74%)     34 (68%)     36 (73%)                               
      Papilla, Necrosis                                2 (4%)                                                                       
      Renal Tubule, Cyst                               2 (4%)       1 (2%)       2 (4%)                                             
      Renal Tubule, Degeneration                                                 1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                 3 (6%)       4 (8%)       2 (4%)       2 (4%)                                
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (2%)                                             
   Urethra                                            (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Urinary Bladder                                    (50)         (50)         (50)         (48)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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