TDMS Study 88032-05 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus OXYMETHOLONE DATE: 11/24/97
EXPERIMENT: 88032 TEST: 05 TIME: 10:26:29
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C88032B
CONT: NO1-ES-05295 CAS: 434-07-01
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS LABORATORY OXYMETHOLONE DATE: 11/24/97
EXPERIMENT: 88032 TEST: 05 TIME: 10:52:39
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 88032B
CONT: NO1-ES-05295 CAS: 434-07-01
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF OXYMETHOLONE
==========================================================================================================
WEEK 0 MG/KG 3 MG/KG 30 MG/KG 150 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 141.8 90 140.4 99.0 90 141.2 99.6 90 141.1 99.5 89*
1 141.8 90 140.4 99.0 90 141.2 99.6 90 141.1 99.5 89*
2 179.8 90 178.3 99.2 90 179.0 99.6 90 175.5 97.6 89*
3 213.7 90 211.7 99.1 90 212.3 99.3 90 200.6 93.9 89*
4 242.3 90 239.6 98.9 90 240.1 99.1 90 218.2 90.1 89*
5 264.1 90 262.1 99.2 90 261.0 98.8 90 233.0 88.2 89
6 281.8 90 278.1 98.7 90 275.9 97.9 90 247.2 87.7 88*
7 298.2 90 293.7 98.5 90 290.0 97.3 90 258.6 86.7 88*
8 310.7 90 308.8 99.4 90 303.8 97.8 90 266.6 85.8 88*
9 321.0 90 320.6 99.9 90 315.4 98.3 90 273.9 85.3 88*
10 331.6 90 329.6 99.4 90 325.5 98.2 90 277.4 83.7 88*
11 343.7 90 340.7 99.1 90 334.4 97.3 90 284.0 82.6 88*
12 352.8 90 348.9 98.9 90 343.2 97.3 90 293.7 83.2 88
13 362.5 90 359.4 99.1 90 351.3 96.9 90 298.7 82.4 87*
17 390.1 80 (I) 389.7 99.9 80 (I) 376.5 96.5 80 (I) 307.3 78.8 78 (I)
21 415.4 80 413.9 99.6 80 396.4 95.4 80 316.6 76.2 75
25 430.8 80 429.4 99.7 79 403.8 93.7 80 322.6 74.9 74
29 444.8 70 (I) 441.4 99.2 69 (I) 412.4 92.7 70 (I) 327.0 73.5 64 (I)
33 455.7 70 454.6 99.8 68 420.1 92.2 70 329.5 72.3 64
37 463.1 70 465.8 100.6 68 425.2 91.8 70 334.7 72.3 64
41 475.8 70 478.8 100.6 68 434.5 91.3 70 339.0 71.2 64
45 484.0 70 487.5 100.7 68 438.6 90.6 69 342.9 70.8 64
49 489.8 69 491.8 100.4 67 441.3 90.1 69 344.5 70.3 64
52 501.4 69 506.9 101.1 67 453.4 90.4 68 347.1 69.2 64
57 505.4 58 (I) 507.2 100.4 57 (I) 455.1 90.0 58 (I) 352.6 69.8 54 (I)
61 505.6 58 515.7 102.0 56 457.1 90.4 58 357.0 70.6 54
65 504.1 57 514.9 102.1 55 459.8 91.2 57 355.7 70.6 53
69 500.1 55 514.8 102.9 55 460.8 92.1 57 349.5 69.9 53
73 499.6 52 518.3 103.7 51 457.9 91.7 57 351.9 70.4 53
77 492.6 50 515.2 104.6 51 452.9 91.9 55 350.6 71.2 53
81 480.6 37 (I) 501.9 104.4 41 (I) 447.3 93.1 44 (I) 341.6 71.1 42 (I)
85 462.4 37 492.9 106.6 38 437.9 94.7 42 344.0 74.4 38
89 464.8 30 489.3 105.3 35 430.9 92.7 38 341.4 73.5 37
93 442.5 29 484.0 109.4 32 428.9 96.9 33 336.6 76.1 32
97 442.1 22 454.6 102.8 31 411.7 93.1 29 334.4 75.6 28
101 436.0 21 430.1 98.6 25 395.6 90.7 23 324.0 74.3 25
TERM. SAC. 15 15 14 20
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR ORAL GAVAGE STUDY OF OXYMETHOLONE
==========================================================================================================
WEEK 0 MG/KG 3 MG/KG 30 MG/KG 100 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 114.2 90 114.1 99.9 90 114.2 100.0 90 115.1 100.8 90
1 114.2 90 114.1 99.9 90 114.2 100.0 90 115.1 100.8 90
2 130.4 90 131.5 100.8 90 133.2 102.1 90 136.4 104.6 90
3 144.7 90 147.1 101.7 90 152.9 105.7 90 160.0 110.6 90
4 153.4 90 156.4 102.0 90 165.4 107.8 90 174.2 113.6 90
5 162.1 90 164.7 101.6 90 177.5 109.5 90 190.4 117.5 90
6 168.9 90 174.3 103.2 90 188.3 111.5 90 201.9 119.5 90
7 174.5 90 181.5 104.0 90 195.2 111.9 90 209.6 120.1 90
8 178.6 90 186.2 104.3 90 200.9 112.5 90 217.4 121.7 90
9 184.5 90 191.0 103.5 90 208.6 113.1 90 223.7 121.2 90
10 186.8 90 196.6 105.2 90 218.0 116.7 90 230.3 123.3 90
11 189.2 90 199.8 105.6 90 223.2 118.0 90 235.7 124.6 90
12 193.2 90 203.5 105.3 90 227.0 117.5 90 239.5 124.0 90
13 195.9 90 206.0 105.2 90 232.3 118.6 90 247.2 126.2 90
17 207.3 80 (I) 220.8 106.5 80 (I) 252.6 121.9 80 (I) 258.7 124.8 80 (I)
21 214.8 80 230.7 107.4 80 267.6 124.6 79 268.6 125.0 80
25 222.6 80 238.0 106.9 80 277.8 124.8 79 274.2 123.2 80
29 227.1 70 (I) 245.3 108.0 70 (I) 284.8 125.4 69 (I) 275.4 121.3 69 (I)
33 231.7 70 251.5 108.5 70 291.5 125.8 69 277.7 119.9 69
37 238.3 70 259.5 108.9 70 299.4 125.6 68 284.6 119.4 69
41 247.3 70 267.4 108.1 70 308.3 124.7 68 286.3 115.8 69
45 259.6 70 278.1 107.1 69 318.6 122.7 68 291.3 112.2 69
49 263.9 70 284.2 107.7 69 322.7 122.3 68 291.0 110.3 69
52 277.5 70 293.2 105.7 69 330.0 118.9 68 294.5 106.1 69
57 285.6 60 (I) 300.0 105.0 59 (I) 335.4 117.4 58 (I) 295.9 103.6 58 (I)
61 294.8 60 309.2 104.9 59 337.3 114.4 58 300.2 101.8 57
65 299.9 60 313.5 104.5 59 339.3 113.1 57 302.4 100.8 57
69 305.8 60 323.6 105.8 59 342.8 112.1 57 299.1 97.8 57
73 304.0 58 324.9 106.9 58 344.6 113.4 54 298.5 98.2 56
77 310.7 57 331.0 106.5 57 347.5 111.8 54 302.5 97.4 54
81 311.7 41 (I) 332.5 106.7 45 (I) 342.0 109.7 43 (I) 298.6 95.8 43 (I)
85 303.1 36 331.1 109.2 41 341.2 112.6 42 299.6 98.8 42
89 315.9 35 340.9 107.9 40 344.8 109.1 42 301.7 95.5 42
93 322.2 33 337.1 104.6 39 341.5 106.0 41 297.7 92.4 41
97 321.5 33 341.9 106.3 34 343.6 106.9 36 305.0 94.9 37
101 321.7 30 344.3 107.0 33 348.1 108.2 32 298.1 92.7 34
TERM. SAC. 25 29 30 31
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.