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TDMS Study 88032-05 Pathology Tables

NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97
Route: GAVAGE                                                                                                     Time: 07:12:38

                                                          27 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  434-07-01

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     10/21/93 - 10/22/93

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    3 MG/KG
                               Include 006    30 MG/KG
                               Include 008    100     MG/KG
                               Include 001    0 MG/KG
                               Include 003    3 MG/KG
                               Include 005    30 MG/KG
                               Include 007    150     MG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          90           90           90           90                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (10)         (10)         (10)         (10)                                   
      Parasite Metazoan                                                          1 (10%)                                            
   Liver                                              (10)         (10)         (10)         (10)                                   
      Basophilic Focus                                              1 (10%)                                                         
      Hepatodiaphragmatic Nodule                       1 (10%)      5 (50%)      1 (10%)      2 (20%)                               
      Inflammation, Chronic Active                     2 (20%)      5 (50%)      4 (40%)      2 (20%)                               
      Centrilobular, Vacuolization Cytoplasmic                                   1 (10%)                                            
   Mesentery                                          (1)                       (1)                                                 
      Fat, Inflammation, Chronic Active                1 (100%)                  1 (100%)                                           
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Acinus, Atrophy                                                                         1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Myocardium, Degeneration, Chronic                5 (50%)      5 (50%)      7 (70%)     10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                3 (30%)      2 (20%)      1 (10%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ultimobranchial Cyst                                          1 (10%)      1 (10%)      2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     6 (60%)      7 (70%)     10 (100%)     8 (80%)                               
   Ovary                                              (10)         (10)         (10)         (10)                                   
      DYSGENESIS                                                                10 (100%)    10 (100%)                              
      Follicle, Cyst                                   1 (10%)                                                                      
      Periovarian Tissue, Cyst                         1 (10%)                                                                      
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Hydrometra                                       2 (20%)      3 (30%)      4 (40%)      1 (10%)                               
      Endometrium, Cyst                                                          1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (10)         (10)         (10)         (10)                                   
      Dilatation                                                                              1 (10%)                               
      Lobular, Hyperplasia                                                      10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                                    1 (10%)                                                         
      Inflammation, Chronic Active                     2 (20%)      4 (40%)      7 (70%)      2 (20%)                               
      Mineralization                                                2 (20%)      4 (40%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Lens, Mineralization                                                       1 (100%)                                           
      Retina, Degeneration                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                                  1 (10%)                                                         
      Mineralization                                  10 (100%)    10 (100%)    10 (100%)     9 (90%)                               
      Nephropathy                                                   1 (10%)      2 (20%)      7 (70%)                               
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          90           90           90           90                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                                                            1 (10%)                               
   Intestine Small, Jejunum                           (10)         (10)         (10)         (10)                                   
      Inflammation, Granulomatous                      1 (10%)                                                                      
      Peyer's Patch, Mineralization                                              1 (10%)                                            
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatodiaphragmatic Nodule                       1 (10%)      1 (10%)      1 (10%)      1 (10%)                               
      Inflammation, Chronic Active                     3 (30%)      1 (10%)      3 (30%)      1 (10%)                               
      Bile Duct, Hyperplasia                           3 (30%)                                                                      
      Centrilobular, Vacuolization Cytoplasmic                      1 (10%)                                                         
   Mesentery                                                       (1)                                                              
      Fat, Inflammation, Chronic Active                             1 (100%)                                                        
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Acinus, Atrophy                                               2 (20%)                                                         
      Vein, Inflammation, Granulomatous                1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)                                   
      Myocardium, Degeneration, Chronic               10 (100%)    10 (100%)     9 (90%)     10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                             1 (10%)      1 (10%)      1 (10%)                               
      Vacuolization Cytoplasmic                       10 (100%)     8 (80%)                   8 (80%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ultimobranchial Cyst                             1 (10%)                                                                      
      Follicle, Cyst                                   2 (20%)                                                                      
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                                               1 (10%)                                            
   Preputial Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 (10%)                                            
      Inflammation, Chronic Active                     7 (70%)     10 (100%)     9 (90%)      8 (80%)                               
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                   1 (10%)                                1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Capsule, Hyperplasia                                                       1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (10)         (10)         (10)         (10)                                   
      Dilatation                                                                              9 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     2 (20%)      3 (30%)      8 (80%)      3 (30%)                               
      Inflammation, Granulomatous                      1 (10%)      2 (20%)                                                         
      Mineralization                                                4 (40%)      4 (40%)      1 (10%)                               
      Vacuolization Cytoplasmic                        1 (10%)      1 (10%)      1 (10%)                                            
   Nose                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 (10%)                   2 (20%)                                            

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 88032-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/25/97  
Route: GAVAGE                                                                                                     Time: 07:12:38  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                   2 (20%)                   1 (10%)      9 (90%)                               
      Nephropathy                                      8 (80%)      7 (70%)      9 (90%)     10 (100%)                              
   Urinary Bladder                                    (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                                  1 (10%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
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