TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 434-07-01 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25026 Other 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2| | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | __________________________________________________________________________| Intestine Large, Colon | + + A A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | A + + A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | A + A A A + A + + + A + + A + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + A + + A + + + A + + A + + + + + + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Hepatocellular Adenoma, Multiple | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + +| Fibrosarcoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2| | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Fibrosarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | Squamous Cell Papilloma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | Leukemia Mononuclear | X | Polyp Stromal | X X X | Cervix, Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + M + + + M + M + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X X X X X| Fibroadenoma, Multiple | X X X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Pinna, Melanoma Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 7| 5| 7| 7| 5| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 7| 3| 4| 7| 6| 2| 0| 2| 2| 4| 2| 2| 2| 2| 8| 4| 0| 0| 2| 2| 2| 6| 0| 2| 2| | 8| 3| 9| 3| 2| 9| 6| 8| 9| 0| 1| 9| 9| 5| 9| 8| 8| 7| 8| 8| 8| 6| 7| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 5| 6| 7| 8| 1| 6| 7| 8| 9| 1| 2| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Leukemia Mononuclear | | __________________________________________________________________________| Skeletal Muscle | + | Fibrosarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| | DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| | | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L | | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + A + + + + + + + + + + A| 44 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A A + + + + + + + + + + + + + + + + + A + + A| 38 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A A + + + + + + + + + A + + + + + + + + + + A| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + A + + A| 40 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma | | 1 | Hepatocellular Adenoma, Multiple | X | 1 | Leukemia Mononuclear | X X X X | 12 | __________________________________________________________________________|____________| Mesentery | + + +| 5 | Fibrosarcoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | Pheochromocytoma Benign | X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| | DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| | | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L | | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| 27 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X X | 5 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Fibrosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 4 | Carcinoma | | 1 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma | | 1 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X | 4 | Cervix, Sarcoma Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | + | 4 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 9 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + M + + + + + + + + +| 45 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 5| | DAY ON TEST | 0| 2| 6| 4| 8| 2| 2| 2| 2| 2| 2| 2| 7| 7| 2| 0| 2| 2| 2| 9| 2| 7| 2| 2| 7| | | 5| 8| 1| 3| 4| 9| 8| 8| 9| 9| 8| 9| 8| 3| 8| 6| 8| 8| 8| 3| 9| 8| 9| 8| 4| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| L | | 9| 0| 2| 3| 4| 6| 7| 8| 9| 1| 5| 7| 8| 0| 1| 4| 5| 4| 8| 1| 2| 3| 4| 5| 6| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 3 | Fibroadenoma | X X X X X X| 15 | Fibroadenoma, Multiple | X X X | 6 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pinna, Melanoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Fibrosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6| DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4| | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + + + A +| Leiomyoma | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + A + A +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + A + + + + + + A + + A + A +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + A + + A + A +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + A + + + + + + A + + A + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Oral Mucosa | | Squamous Cell Carcinoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6| DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4| | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X X | Leukemia Mononuclear | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X | Sarcoma Stromal | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 5| 6| 6| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 6| DAY ON TEST | 8| 2| 7| 5| 5| 2| 2| 0| 3| 0| 2| 9| 2| 2| 2| 2| 2| 2| 1| 9| 2| 5| 2| 9| 4| | 2| 9| 6| 2| 2| 9| 5| 5| 9| 2| 8| 9| 3| 8| 9| 8| 9| 9| 1| 0| 9| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| | 2| 4| 5| 7| 9| 1| 2| 3| 5| 6| 7| 8| 0| 2| 4| 6| 7| 9| 1| 2| 4| 5| 7| 0| 4| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma, Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesenchymal Tumor Benign | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| | | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 46 | Leiomyoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X| 11 | __________________________________________________________________________|____________| Mesentery | + | 3 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X| 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 6 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| | | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 26 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X| 1 | C-Cell, Adenoma | X X X X X X | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Adenoma | X X X X | 4 | Carcinoma | | 3 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X| 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 2 | Polyp Stromal | X X X | 8 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X| 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X| 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X| 9 | __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + + + + + + M M +| 47 | Leukemia Mononuclear | X X| 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 2| 7| 2| 2| 2| 2| 2| 7| 6| 2| 2| 2| 3| 2| | | 8| 8| 5| 9| 8| 8| 8| 8| 8| 1| 9| 8| 0| 8| 9| 8| 9| 9| 9| 2| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 3 MG/KG | 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 6| 9| 1| 2| 4| 6| 0| 1| 2| 3| 6| 7| 1| 5| 7| 9| 0| 1| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | X X X X X| 11 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | +| 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 4 | Sarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 3 | Mesenchymal Tumor Benign | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9| | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + A + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | __________________________________________________________________________| Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + A| Lymphoma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X | Lymphoma Malignant | | __________________________________________________________________________| Mesentery | + + + + + | Lymphoma Malignant | | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant | | Atrium, Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9| | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant | | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________________________________________| Parathyroid Gland | M + + + + M + + M + M + + + + + + + + + M + + + M| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Leukemia Mononuclear | X | Squamous Cell Papilloma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X | Lymphoma Malignant | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X | Lymphoma Malignant | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant | | __________________________________________________________________________| Thymus | + + + + + M M M + + + + + + + + + + M + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 4| 7| 1| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 4| DAY ON TEST | 7| 2| 1| 2| 2| 4| 2| 9| 2| 2| 2| 7| 2| 7| 2| 2| 0| 2| 6| 2| 2| 2| 2| 2| 9| | 8| 9| 8| 8| 8| 1| 8| 8| 8| 8| 9| 4| 9| 0| 8| 8| 8| 9| 1| 8| 9| 9| 9| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 MG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 2| 3| 5| 6| 8| 9| 0| 1| 3| 4| 5| 7| 8| 0| 1| 2| 5| 6| 8| 9| 0| 2| 3| 5| 8| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + M + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X | Lymphoma Malignant | | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Lymphoma Malignant | | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| | | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L | | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A M + + + + + + + + + + + + A + + +| 46 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + A + A + + + + + + + + + + M A + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + A + A + + + + + + + + + + A A + + +| 43 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + A A + + +| 44 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X | 10 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Mesentery | + + + + + + +| 12 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Lymphoma Malignant | X | 1 | Atrium, Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| | | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L | | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 6 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | Lymphoma Malignant | X | 1 | Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + M + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X | 18 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X X | 7 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | | 1 | Leukemia Mononuclear | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Lymphoma Malignant | X | 1 | Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 5 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Lymph Node | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| | | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L | | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 2 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 3 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 10 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + M + + + + +| 44 | Lymphoma Malignant | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Fibroadenoma | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X X X | 4 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 6 | Alveolar/Bronchiolar Carcinoma | X | 1 | Leukemia Mononuclear | X | 4 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 5| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 5| 2| 5| 6| 2| 2| 2| 6| 9| 1| 7| 2| 2| 2| 2| 2| 2| 2| 9| 2| 3| 7| 2| 2| 2| | | 9| 8| 3| 5| 8| 9| 9| 0| 3| 3| 8| 9| 9| 9| 8| 8| 8| 9| 3| 8| 8| 1| 9| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 30 MG/KG | 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| L | | 9| 0| 1| 6| 8| 9| 0| 2| 3| 6| 7| 1| 4| 5| 7| 9| 1| 2| 5| 8| 3| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Lymphoma Malignant | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Lymphoma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 11 | Lymphoma Malignant | X X | 2 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6| DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2| | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + M + + + + A + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + A + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + M + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X X | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + M + + + + + M + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6| DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2| | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + M + + + M + + M + + M + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Lipoma | X | Sweat Gland, Carcinoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + M + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 1| 7| 6| 7| 6| DAY ON TEST | 3| 2| 2| 2| 1| 2| 7| 2| 5| 6| 2| 9| 2| 9| 2| 2| 2| 2| 2| 2| 7| 2| 5| 2| 2| | 9| 8| 9| 8| 0| 9| 4| 9| 9| 3| 8| 5| 9| 4| 8| 9| 5| 9| 8| 9| 7| 8| 9| 9| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 100 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| MG/KG | 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 2| 4| 5| 7| 8| 0| 3| 4| 1| 2| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + M + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Transitional Epithelium, Carcinoma | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| | DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| | | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + A + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | X X | 2 | Hepatocellular Adenoma | X X X X | 8 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Mesentery | + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Pheochromocytoma Benign | X X X | 6 | Bilateral, Pheochromocytoma Benign | | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + M + + M + M M + + M + + M + + + +| 38 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Pars Distalis, Adenoma | X X X X X X X X X X| 14 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| | DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| | | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X X X| 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | Carcinoma | X | 3 | __________________________________________________________________________|____________| Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Thymus | + + + + + M M + + M + + M + + + + + + + + + + + +| 42 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 2 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Lipoma | | 1 | Sweat Gland, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 7| 3| 7| | DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 0| 2| 1| 2| 1| 9| 2| 2| 2| 5| 2| 8| 2| | | 9| 0| 8| 8| 8| 8| 9| 9| 9| 8| 2| 8| 4| 8| 3| 8| 1| 0| 8| 9| 9| 9| 8| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 100 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L | MG/KG | 4| 5| 6| 8| 9| 1| 6| 7| 0| 1| 3| 4| 5| 7| 0| 1| 3| 4| 5| 0| 2| 3| 4| 8| 9| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | + | 2 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | Renal Tubule, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyoma | X | 1 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7| DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1| | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + A + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + A + + M + A + + A A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + A + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A A + A A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + A A + + A + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X X | __________________________________________________________________________| Oral Mucosa | + + + | Squamous Cell Papilloma | X | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + A + + A + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X X X X X X X | Bilateral, Pheochromocytoma Benign | X X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7| DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1| | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + A + + + + +| Adenoma | X X X| Leukemia Mononuclear | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + A + + + + M + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | M + + + + + M + + + + + + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7| DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1| | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Leukemia Mononuclear | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + | Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Peripheral Nerve | M + + +| __________________________________________________________________________| Spinal Cord | + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + M + + + + + + + + + + + + + + + + + + + + +| Glands, Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Transitional Epithelium, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 7| 7| 5| 5| 7| 7| 5| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 6| 5| 7| 7| DAY ON TEST | 4| 6| 9| 1| 0| 2| 9| 4| 2| 2| 4| 0| 6| 2| 7| 5| 0| 2| 3| 9| 2| 1| 1| 2| 1| | 6| 6| 6| 1| 7| 8| 1| 9| 8| 8| 9| 2| 0| 8| 9| 4| 0| 8| 3| 2| 0| 1| 9| 8| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| | 1| 2| 4| 5| 0| 4| 6| 9| 0| 1| 2| 3| 8| 9| 0| 2| 4| 6| 7| 9| 2| 4| 7| 8| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4| DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2| | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A| Histiocytic Sarcoma | | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + A A| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + A A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Oral Mucosa | | Squamous Cell Papilloma | | Pharyngeal, Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4| DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2| | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + M + + + + + M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + + M + M M + + + + + + + + + + + M + + + + + + M| _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4| DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2| | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X | Leukemia Mononuclear | X | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Carcinoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Transitional Epithelium, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 4| 5| 7| 3| 3| 7| 7| 3| 7| 5| 6| 5| 4| 7| 7| 7| 7| 7| 4| 4| DAY ON TEST | 0| 5| 0| 4| 8| 8| 2| 2| 6| 1| 2| 2| 8| 2| 5| 5| 8| 6| 2| 2| 1| 2| 2| 7| 2| | 6| 7| 5| 6| 6| 6| 4| 8| 6| 6| 8| 8| 4| 8| 3| 4| 9| 4| 8| 8| 4| 8| 8| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 9| 2| 3| 4| 7| 0| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 0| | A | 0 MG/KG | 8| | L | | 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 49 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 43 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 44 | __________________________________________________________________________|____________| Liver | + | 51 | Hepatocellular Adenoma, Multiple | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 20 | __________________________________________________________________________|____________| Mesentery | | 14 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Oral Mucosa | | 3 | Squamous Cell Papilloma | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + | 51 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 51 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 51 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Heart | + | 51 | Leukemia Mononuclear | X | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 51 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 0| | A | 0 MG/KG | 8| | L | | 8| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | | 7 | __________________________________________________________________________|____________| Adrenal Medulla | + | 51 | Leukemia Mononuclear | | 6 | Pheochromocytoma Benign | X | 16 | Bilateral, Pheochromocytoma Benign | | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 49 | Adenoma | | 4 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 46 | __________________________________________________________________________|____________| Pituitary Gland | + | 51 | Leukemia Mononuclear | | 2 | Pars Distalis, Adenoma | | 30 | __________________________________________________________________________|____________| Thyroid Gland | + | 51 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 51 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Preputial Gland | + | 51 | Carcinoma | | 3 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Prostate | + | 51 | Leukemia Mononuclear | X | 4 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + | 51 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Testes | + | 51 | Leukemia Mononuclear | X | 3 | Mesothelioma Malignant | | 2 | Bilateral, Interstitial Cell, Adenoma| X | 31 | Interstitial Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 0| | A | 0 MG/KG | 8| | L | | 8| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 11 | __________________________________________________________________________|____________| Lymph Node | + | 4 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 51 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 50 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Spleen | + | 51 | Leukemia Mononuclear | X | 18 | __________________________________________________________________________|____________| Thymus | + | 42 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 51 | Fibroadenoma | X | 4 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Skin | + | 51 | Keratoacanthoma | | 4 | Leukemia Mononuclear | X | 2 | Sebaceous Gland, Adenoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 51 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 51 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Peripheral Nerve | | 4 | __________________________________________________________________________|____________| Spinal Cord | | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 51 | Alveolar/Bronchiolar Adenoma | | 4 | Alveolar/Bronchiolar Carcinoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 0| | A | 0 MG/KG | 8| | L | | 8| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 9 | __________________________________________________________________________|____________| Nose | + | 50 | Glands, Carcinoma | | 1 | __________________________________________________________________________|____________| Trachea | + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 51 | Leukemia Mononuclear | | 8 | Transitional Epithelium, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 51 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 51 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 21 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7| DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2| | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + A + + + + A + A + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + A A + + + + + A + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Oral Mucosa | | Squamous Cell Papilloma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Myocardium, Schwannoma Benign | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Ganglioneuroma | | Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| Adenoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + + + + + + + + M +| Leukemia Mononuclear | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7| DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2| | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Benign | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Benign | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X | Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + | Mediastinal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Rhabdomyosarcoma, Metastatic, | | Skeletal Muscle | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + M M + + + + + + + + M + + + + M M + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 4| 4| 4| 3| 7| 6| 7| 6| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 6| 5| 7| DAY ON TEST | 2| 0| 0| 9| 2| 8| 8| 2| 2| 5| 2| 2| 2| 2| 1| 0| 0| 7| 9| 2| 7| 2| 9| 9| 2| | 0| 7| 0| 2| 4| 5| 5| 1| 8| 9| 8| 9| 8| 8| 4| 9| 6| 9| 3| 8| 9| 8| 2| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3 MG/KG | 9| 9| 9| 9| 9| 9| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | 1| 2| 3| 4| 6| 8| 2| 9| 1| 2| 3| 5| 7| 8| 9| 1| 3| 4| 5| 6| 8| 9| 0| 1| 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Fibroadenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X | Mediastinum, Mesothelioma Malignant | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Renal Tubule, Adenoma | | Renal Tubule, Oncocytoma Benign | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Mesothelioma Benign | X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| | | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A A + + + + + + + + A + A A + + + + + + + + + +| 40 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A A + + + + + A + + A + A A + + + + + + + + + +| 39 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A A + + + + + + + + + + A A + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X| 15 | __________________________________________________________________________|____________| Mesentery | + + + | 6 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X| 4 | Myocardium, Schwannoma Benign | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ganglioneuroma | X | 1 | Leukemia Mononuclear | X X | 5 | Pheochromocytoma Benign | X X X X X X | 14 | Bilateral, Pheochromocytoma Benign | X X X X X X| 11 | __________________________________________________________________________|____________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| | | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + M + M + +| 44 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 32 | __________________________________________________________________________|____________| Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | X X X | 3 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Benign | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Adenoma | | 2 | Carcinoma | | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Mesothelioma Benign | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X | 9 | Interstitial Cell, Adenoma | X X X X | 11 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + | 4 | Mediastinal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + A M + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| | | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Rhabdomyosarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 14 | __________________________________________________________________________|____________| Thymus | M + M + + + + + + + + + + + + + M + + + + + + + +| 42 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Fibroadenoma | | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibroma | X X X X | 5 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Leukemia Mononuclear | X X X | 6 | Mediastinum, Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| 2| 4| 5| 6| 7| 6| 7| 7| 7| 5| 5| 6| 1| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 0| 9| 6| 7| 2| 2| 0| 1| 0| 9| 8| 1| 4| 0| 0| 6| 2| 2| 7| 0| 2| 2| 2| 2| | | 8| 2| 9| 3| 5| 8| 2| 6| 8| 9| 8| 8| 8| 6| 3| 8| 1| 8| 8| 5| 3| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 3 MG/KG | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L | | 5| 6| 9| 3| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 9| 4| 5| 8| 9| 3| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | Renal Tubule, Adenoma | X | 1 | Renal Tubule, Oncocytoma Benign | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 15 | Mesothelioma Benign | | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9| | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + A + A A + + + + + + + + + + A + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + A + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + A A A + + + + + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Adenoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X| Bilateral, Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9| | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lipoma | X | __________________________________________________________________________| Thymus | + M + + + + M + + + + + + M + + M M + + M + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Carcinoma | | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Squamous Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Chordoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 7| 5| 6| 5| 7| 6| 6| 7| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 6| DAY ON TEST | 8| 0| 2| 9| 9| 0| 1| 5| 6| 0| 4| 2| 2| 9| 2| 2| 8| 4| 2| 6| 4| 2| 2| 2| 9| | 1| 6| 8| 2| 7| 0| 7| 3| 4| 5| 0| 9| 8| 3| 8| 8| 0| 4| 8| 6| 4| 8| 7| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| | 1| 2| 3| 4| 5| 6| 8| 0| 2| 3| 4| 6| 7| 8| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Leukemia Mononuclear | X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Olfactory Epithelium, Neoplasm NOS | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Lids, Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| | DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| | | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + A + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + A + + + A + + + A + + + + +| 41 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + A + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + A + + + A + + + A + + + + +| 41 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Mesentery | + + + + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Adenoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X X | 12 | Bilateral, Pheochromocytoma Benign | X X X X | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Carcinoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X | 30 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| | DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| | | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 5 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | Lipoma | | 1 | __________________________________________________________________________|____________| Thymus | + M + + + + M + + M M + + + + + M + + + + M + + +| 38 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X| 1 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Keratoacanthoma | X | 1 | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 7| 5| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 2| 3| | DAY ON TEST | 0| 6| 6| 2| 1| 3| 2| 0| 7| 3| 0| 1| 2| 2| 2| 2| 2| 0| 2| 0| 2| 0| 2| 8| 5| | | 5| 6| 9| 8| 6| 8| 8| 7| 7| 7| 3| 9| 8| 7| 8| 2| 8| 9| 8| 3| 8| 1| 8| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 30 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| L | | 2| 5| 7| 9| 0| 1| 2| 4| 7| 8| 0| 3| 4| 5| 6| 7| 0| 3| 7| 8| 1| 2| 4| 7| 8| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X X | 2 | __________________________________________________________________________|____________| Peripheral Nerve | + + + | 4 | __________________________________________________________________________|____________| Spinal Cord | + + + | 4 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Chordoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Leukemia Mononuclear | X X | 3 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | | 1 | Olfactory Epithelium, Neoplasm NOS | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Lids, Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2| | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + A + A + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + M + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + A + A A + + + M + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + A A + + + + + + + + + A + + + + + + M + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + M + M + + +| Leukemia Mononuclear | X | Atrium, Mesothelioma Malignant | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X X X X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M M M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| C-Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2| | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | | Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + M M M M + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | Fibroadenoma, Multiple | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + M + M + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 7| 6| 5| 5| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 1| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| DAY ON TEST | 0| 4| 5| 6| 2| 7| 2| 6| 2| 6| 2| 2| 7| 2| 1| 3| 6| 2| 2| 3| 1| 5| 2| 2| 2| | 3| 1| 1| 3| 8| 5| 8| 0| 8| 6| 8| 8| 5| 8| 4| 9| 1| 8| 8| 6| 1| 9| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 150 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| MG/KG | 2| 4| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 9| 0| 2| 4| 5| 8| 9| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | | Renal Tubule, Adenoma | X | Renal Tubule, Oncocytoma Benign | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant | X| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2| | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Duodenum | M + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + A + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + A + A + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Atrium, Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X| Bilateral, Pheochromocytoma Benign | X X X X X X X X | __________________________________________________________________________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + M + + M M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2| | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | M + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Thymus | M M M + + + + M + + + M + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Osteoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | M + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 _____________________________________________________________________________________________________________________ | 0| 7| 5| 6| 1| 7| 7| 7| 5| 4| 1| 6| 0| 0| 1| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 3| 0| 7| 4| 4| 2| 2| 2| 6| 3| 1| 8| 9| 8| 1| 2| 2| 2| 2| 1| 4| 2| 1| 2| 2| | 4| 8| 7| 4| 5| 8| 8| 8| 3| 4| 5| 8| 2| 0| 6| 8| 8| 9| 4| 5| 6| 8| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 150 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 0| 3| 5| 6| 7| 9| 1| 5| 6| 7| 8| 9| 0| 3| 5| 6| 0| 3| 8| 0| 2| 5| 6| 8| 9| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Renal Tubule, Adenoma | X | Renal Tubule, Oncocytoma Benign | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 3| | A | 150 | 6| | L | MG/KG | 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + | 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + | 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + | 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 41 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 41 | __________________________________________________________________________|____________| Liver | + | 49 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | + | 48 | __________________________________________________________________________|____________| Salivary Glands | + | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 48 | __________________________________________________________________________|____________| Stomach, Glandular | + | 48 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 48 | __________________________________________________________________________|____________| Heart | + | 47 | Leukemia Mononuclear | | 2 | Atrium, Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 49 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + | 49 | Leukemia Mononuclear | | 2 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 10 | Bilateral, Pheochromocytoma Benign | X | 19 | __________________________________________________________________________|____________| Islets, Pancreatic | + | 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + | 43 | __________________________________________________________________________|____________| Pituitary Gland | + | 49 | Pars Distalis, Adenoma | | 19 | __________________________________________________________________________|____________| Thyroid Gland | + | 49 | C-Cell, Adenoma | | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 3| | A | 150 | 6| | L | MG/KG | 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 49 | __________________________________________________________________________|____________| Preputial Gland | + | 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + | 49 | __________________________________________________________________________|____________| Seminal Vesicle | + | 48 | __________________________________________________________________________|____________| Testes | + | 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node | | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Spleen | + | 48 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Thymus | + | 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + | 50 | Fibroadenoma | | 1 | Fibroadenoma, Multiple | | 1 | __________________________________________________________________________|____________| Skin | + | 50 | Keratoacanthoma | | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + | 50 | Osteoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + | 47 | Alveolar/Bronchiolar Adenoma | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 88032-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97 Route: GAVAGE Time: 11:19:27 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 8| | | _____________________________________________________________________________________________________________________| T (*) | | 0| | O | FISCHER 344 RATS MALE | 0| | T | ANIMAL ID | 3| | A | 150 | 6| | L | MG/KG | 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Nose | + | 50 | __________________________________________________________________________|____________| Trachea | + | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + | 49 | Leukemia Mononuclear | | 1 | Renal Tubule, Adenoma | | 2 | Renal Tubule, Oncocytoma Benign | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------