TDMS Study 88032-05 Pathology Tables
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
79 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 434-07-01
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 10/20/94 - 10/21/94
Treatment Groups: Include 002 0 MG/KG
Include 004 3 MG/KG
Include 006 30 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 3 MG/KG
Include 005 30 MG/KG
Include 007 150 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatocellular Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (10) (10) (10) (10)
Pheochromocytoma Benign 1 (10%)
Islets, Pancreatic (10) (10) (10) (10)
Carcinoma 1 (10%)
Pituitary Gland (10) (9) (10) (10)
Pars Distalis, Adenoma 3 (30%) 3 (33%) 1 (10%) 2 (20%)
Thyroid Gland (10) (10) (10) (10)
C-Cell, Adenoma 2 (20%) 2 (20%)
Follicular Cell, Carcinoma 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (9) (10) (8) (10)
Adenoma 2 (20%)
Uterus (10) (10) (10) (10)
Carcinoma 1 (10%)
Polyp Stromal 1 (10%) 1 (10%) 1 (10%)
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NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10)
Spleen (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Carcinoma 1 (10%)
Fibroadenoma 3 (30%) 1 (10%) 1 (10%) 1 (10%)
Skin (10) (10) (10) (10)
Hemangiopericytoma 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Mononuclear 1 (10%)
* Number of animals with any tissue examined microscopically
Page 3
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(10) *(10) *(10) *(10)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 8 4 5 5
Total Primary Neoplasms 11 8 7 8
Total Animals with Benign Neoplasms 6 4 5 5
Total Benign Neoplasms 8 7 7 7
Total Animals with Malignant Neoplasms 3 1 1
Total Malignant Neoplasms 3 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (10) (10) (10) (10)
Liver (10) (10) (10) (10)
Pancreas (10) (10) (10) (10)
Acinus, Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pheochromocytoma Malignant 1 (10%)
Pheochromocytoma Benign 1 (10%) 1 (10%) 1 (10%)
Islets, Pancreatic (10) (10) (10) (10)
Adenoma 1 (10%)
Pituitary Gland (10) (10) (10) (9)
Pars Distalis, Adenoma 2 (20%) 6 (60%) 9 (90%) 5 (56%)
Thyroid Gland (10) (10) (10) (10)
C-Cell, Adenoma 1 (10%)
C-Cell, Carcinoma 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10) (10)
Adenoma 1 (10%)
Carcinoma 1 (10%)
Testes (10) (10) (10) (10)
Bilateral, Interstitial Cell, Adenoma 7 (70%) 2 (20%)
Interstitial Cell, Adenoma 2 (20%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10)
Lymph Node (1)
Lymph Node, Mandibular (10) (10) (10) (10)
Lymph Node, Mesenteric (10) (10) (10) (10)
Spleen (10) (10) (10) (10)
Thymus (10) (10) (9) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Keratoacanthoma 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10)
Chordoma, Metastatic, Uncertain Primary Site 1 (10%)
Squamous Cell Carcinoma 1 (11%)
Nose (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Mononuclear 2 (20%) 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OXYMETHOLONE Date: 11/24/97
Route: GAVAGE Time: 11:09:28
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 10 9 6
Total Primary Neoplasms 15 14 14 8
Total Animals with Benign Neoplasms 10 10 9 6
Total Benign Neoplasms 12 13 12 7
Total Animals with Malignant Neoplasms 3 1 2 1
Total Malignant Neoplasms 3 1 2 1
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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