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TDMS Study 88032-05 Pathology Tables

NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97
Route: GAVAGE                                                                                                     Time: 11:09:28

                                                          79 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  434-07-01

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     10/20/94 - 10/21/94

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    3 MG/KG
                               Include 006    30 MG/KG
                               Include 008    100     MG/KG
                               Include 001    0 MG/KG
                               Include 003    3 MG/KG
                               Include 005    30 MG/KG
                               Include 007    150     MG/KG



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          90           90           90           90                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hepatocellular Adenoma                                                                  1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Pheochromocytoma Benign                          1 (10%)                                                                      
   Islets, Pancreatic                                 (10)         (10)         (10)         (10)                                   
      Carcinoma                                                                               1 (10%)                               
   Pituitary Gland                                    (10)         (9)          (10)         (10)                                   
      Pars Distalis, Adenoma                           3 (30%)      3 (33%)      1 (10%)      2 (20%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      C-Cell, Adenoma                                                            2 (20%)      2 (20%)                               
      Follicular Cell, Carcinoma                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (9)          (10)         (8)          (10)                                   
      Adenoma                                                       2 (20%)                                                         
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Carcinoma                                        1 (10%)                                                                      
      Polyp Stromal                                    1 (10%)      1 (10%)      1 (10%)                                            

                                                             Page   2                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)                                   
   Spleen                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (10)         (10)         (10)         (10)                                   
      Carcinoma                                        1 (10%)                                                                      
      Fibroadenoma                                     3 (30%)      1 (10%)      1 (10%)      1 (10%)                               
   Skin                                               (10)         (10)         (10)         (10)                                   
      Hemangiopericytoma                                                         1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (10%)      1 (10%)                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Leukemia Mononuclear                             1 (10%)                                                                      
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   3                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
____________________________________________________________________________________________________________________________________

                                                             Page   4                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             8           4           5           5                                       
     Total Primary Neoplasms                           11           8           7           8                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  6           4           5           5                                       
     Total Benign Neoplasms                             8           7           7           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               3           1                       1                                       
     Total Malignant Neoplasms                          3           1                       1                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   5                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          90           90           90           90                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (10)         (10)         (10)         (10)                                   
   Liver                                              (10)         (10)         (10)         (10)                                   
   Pancreas                                           (10)         (10)         (10)         (10)                                   
      Acinus, Adenoma                                               1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Pheochromocytoma Malignant                       1 (10%)                                                                      
      Pheochromocytoma Benign                          1 (10%)                   1 (10%)      1 (10%)                               
   Islets, Pancreatic                                 (10)         (10)         (10)         (10)                                   
      Adenoma                                                       1 (10%)                                                         
   Pituitary Gland                                    (10)         (10)         (10)         (9)                                    
      Pars Distalis, Adenoma                           2 (20%)      6 (60%)      9 (90%)      5 (56%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      C-Cell, Adenoma                                                                         1 (10%)                               
      C-Cell, Carcinoma                                                                       1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   6                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (10)         (10)         (10)                                   
      Adenoma                                                                    1 (10%)                                            
      Carcinoma                                                     1 (10%)                                                         
   Testes                                             (10)         (10)         (10)         (10)                                   
      Bilateral, Interstitial Cell, Adenoma            7 (70%)      2 (20%)                                                         
      Interstitial Cell, Adenoma                       2 (20%)      3 (30%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)                                   
   Lymph Node                                                                   (1)                                                 
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)                                   
   Spleen                                             (10)         (10)         (10)         (10)                                   
   Thymus                                             (10)         (10)         (9)          (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Keratoacanthoma                                                            1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (9)          (10)                                   
      Chordoma, Metastatic, Uncertain Primary Site                  1 (10%)                                                         
      Squamous Cell Carcinoma                                                    1 (11%)                                            
   Nose                                               (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________

                                                             Page   7                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Leukemia Mononuclear                             2 (20%)                   1 (10%)                                            
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   8                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:09:28  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            10          10           9           6                                       
     Total Primary Neoplasms                           15          14          14           8                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 10          10           9           6                                       
     Total Benign Neoplasms                            12          13          12           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               3           1           2           1                                       
     Total Malignant Neoplasms                          3           1           2           1                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                                                               
     Total Metastatic Neoplasm                                      1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   9                                                               
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