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TDMS Study 88032-05 Pathology Tables

NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97
Route: GAVAGE                                                                                                     Time: 11:24:36

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  434-07-01

       Lock Date:  01/02/96

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25026 Other
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          90           90           90           90                                     
  Early Deaths                                                                                                                      
    Natural Death                                     15           10            9            8                                     
    Moribund Sacrifice                                 9           11           10           10                                     
    Dosing Accident                                    1                         1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           29           30           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (46)         (49)         (48)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Intestine Large, Rectum                            (44)         (47)         (46)         (50)                                   
   Intestine Large, Cecum                             (38)         (44)         (42)         (45)                                   
   Intestine Small, Duodenum                          (47)         (48)         (49)         (49)                                   
   Intestine Small, Jejunum                           (43)         (45)         (43)         (44)                                   
   Intestine Small, Ileum                             (40)         (44)         (44)         (46)                                   
   Liver                                              (50)         (50)         (50)         (49)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Hepatocellular Carcinoma                                                                2 (4%)                                
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)       8 (16%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Mesentery                                          (5)          (3)          (12)         (10)                                   
      Fibrosarcoma                                     1 (20%)                                                                      
   Oral Mucosa                                                     (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Pancreas                                           (50)         (49)         (49)         (49)                                   
   Salivary Glands                                    (50)         (49)         (50)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Tongue                                                          (1)                       (1)                                    
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
   Heart                                              (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                          7 (14%)      4 (8%)       2 (4%)       6 (12%)                               
      Bilateral, Pheochromocytoma Benign                                                      4 (8%)                                
   Islets, Pancreatic                                 (49)         (49)         (49)         (49)                                   
      Adenoma                                                       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (49)         (50)                                   
      Pars Distalis, Adenoma                          27 (54%)     26 (52%)     18 (37%)     14 (28%)                               
   Thyroid Gland                                      (50)         (49)         (50)         (49)                                   
      C-Cell, Adenoma                                  5 (10%)      8 (16%)      7 (14%)      4 (8%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (48)         (50)         (50)                                   
      Adenoma                                          4 (8%)       4 (8%)       2 (4%)       2 (4%)                                
      Carcinoma                                        1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Squamous Cell Papilloma                          2 (4%)                    1 (2%)                                             
   Ovary                                              (50)         (49)         (50)         (49)                                   
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Fibrosarcoma                                     1 (2%)                                                                       
      Hemangiosarcoma                                                                         1 (2%)                                
      Polyp Stromal                                    4 (8%)       8 (16%)      2 (4%)                                             
      Sarcoma Stromal                                               1 (2%)                                                          
      Cervix, Sarcoma Stromal                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (49)                                   
   Lymph Node                                         (4)          (1)          (1)          (1)                                    
   Lymph Node, Mandibular                             (49)         (48)         (48)         (48)                                   
   Lymph Node, Mesenteric                             (50)         (48)         (49)         (49)                                   
   Spleen                                             (50)         (49)         (50)         (49)                                   
   Thymus                                             (45)         (47)         (44)         (42)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Carcinoma                                        3 (6%)                                                                       
      Fibroadenoma                                    15 (30%)     11 (22%)      1 (2%)       4 (8%)                                
      Fibroadenoma, Multiple                           6 (12%)                                                                      
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                                            4 (8%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                                 2 (4%)                                
      Pinna, Melanoma Malignant                        1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                               1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Sweat Gland, Carcinoma                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
   Skeletal Muscle                                    (1)                                                                           
      Fibrosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (49)                                   
      Alveolar/Bronchiolar Adenoma                                               6 (12%)      1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Sarcoma, Metastatic, Bone                                     1 (2%)                                                          

                                                             Page   4                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Nose                                               (49)         (50)         (49)         (50)                                   
   Trachea                                            (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Mesenchymal Tumor Benign                                      1 (2%)                                                          
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Leiomyoma                                                                               1 (2%)                                
      Transitional Epithelium, Carcinoma                                                      1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            12 (24%)     11 (22%)     11 (22%)      5 (10%)                               
      Lymphoma Malignant                                                         2 (4%)                                             
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      30 MG/KG     100                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          45          37          37                                       
     Total Primary Neoplasms                           94          85          61          66                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          40          29          33                                       
     Total Benign Neoplasms                            72          66          45          52                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          18          16          12                                       
     Total Malignant Neoplasms                         22          19          16          14                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                                               
     Total Metastatic Neoplasm                          2           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          90           90           90           90                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           22           25           15                                     
    Natural Death                                     12           12           11           12                                     
    Dosing Accident                                                 1                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           14           20                                     
  Other                                                                                       1                                     

  Animals Examined Microscopically                    51           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (46)         (47)                                   
   Intestine Large, Rectum                            (49)         (47)         (47)         (46)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Large, Cecum                             (43)         (40)         (41)         (44)                                   
   Intestine Small, Duodenum                          (48)         (49)         (49)         (47)                                   
   Liver                                              (51)         (50)         (50)         (49)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                                        1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (14)         (6)          (5)          (3)                                    
   Oral Mucosa                                        (3)          (1)                                                              
      Squamous Cell Papilloma                          1 (33%)      1 (100%)                                                        
      Pharyngeal, Squamous Cell Papilloma              1 (33%)                                                                      
   Pancreas                                           (49)         (48)         (50)         (48)                                   
      Acinus, Adenoma                                                            1 (2%)                                             
   Stomach, Forestomach                               (51)         (50)         (49)         (48)                                   
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
   Tongue                                             (1)                       (1)          (1)                                    
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (51)         (50)         (50)         (48)                                   
   Heart                                              (51)         (49)         (50)         (47)                                   
      Myocardium, Schwannoma Benign                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (51)         (50)         (50)         (49)                                   
   Adrenal Medulla                                    (51)         (50)         (50)         (49)                                   
      Ganglioneuroma                                                1 (2%)                                                          
      Pheochromocytoma Malignant                                                 1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                         16 (31%)     14 (28%)     12 (24%)     10 (20%)                               
      Bilateral, Pheochromocytoma Benign               3 (6%)      11 (22%)      9 (18%)     19 (39%)                               
   Islets, Pancreatic                                 (49)         (48)         (50)         (48)                                   
      Adenoma                                          4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Carcinoma                                                                  2 (4%)                                             
   Parathyroid Gland                                  (46)         (44)         (48)         (43)                                   
   Pituitary Gland                                    (51)         (50)         (50)         (49)                                   
      Pars Distalis, Adenoma                          30 (59%)     32 (64%)     30 (60%)     19 (39%)                               
   Thyroid Gland                                      (51)         (48)         (50)         (49)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  5 (10%)      3 (6%)       5 (10%)      4 (8%)                                
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (51)         (50)         (50)         (49)                                   
   Preputial Gland                                    (51)         (49)         (50)         (49)                                   
      Adenoma                                                       2 (4%)       2 (4%)                                             
      Carcinoma                                        3 (6%)       2 (4%)                    1 (2%)                                
   Prostate                                           (51)         (50)         (50)         (49)                                   
   Seminal Vesicle                                    (51)         (49)         (50)         (48)                                   
   Testes                                             (51)         (50)         (50)         (49)                                   
      Bilateral, Interstitial Cell, Adenoma           31 (61%)      9 (18%)                                                         
      Interstitial Cell, Adenoma                       2 (4%)      11 (22%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (49)         (50)         (49)                                   
   Lymph Node                                         (4)          (4)                       (2)                                    
   Lymph Node, Mandibular                             (51)         (47)         (50)         (49)                                   
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                 1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (48)                                   
   Spleen                                             (51)         (50)         (50)         (48)                                   
      Lipoma                                                                     1 (2%)                                             

                                                             Page   8                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (42)         (42)         (38)         (39)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (48)         (49)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibroadenoma, Multiple                                                                  1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Skin                                               (51)         (50)         (49)         (50)                                   
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Keratoacanthoma                                  4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  5 (10%)      2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (51)         (49)         (50)         (50)                                   
      Osteoma                                                                                 1 (2%)                                
   Skeletal Muscle                                    (2)          (1)                                                              
      Histiocytic Sarcoma                              1 (50%)                                                                      
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      2 (4%)                                             
   Spinal Cord                                        (5)          (1)          (4)                                                 
      Schwannoma Malignant                                                       1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)         (50)         (50)         (47)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)                    3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       

                                                             Page   9                                                               
NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Adrenal Medulla                                                        1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Glands, Carcinoma                                1 (2%)                                                                       
      Olfactory Epithelium, Neoplasm NOS                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (2)          (3)                                    
      Lids, Squamous Cell Carcinoma                                              1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (51)         (50)         (50)         (49)                                   
      Renal Tubule, Adenoma                                         1 (2%)                    2 (4%)                                
      Renal Tubule, Oncocytoma Benign                               1 (2%)                    1 (2%)                                
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (51)         (50)         (50)         (49)                                   
      Transitional Epithelium, Papilloma                                         1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(51)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            21 (41%)     15 (30%)      7 (14%)      4 (8%)                                
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                           2 (4%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

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NTP Experiment-Test: 88032-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            OXYMETHOLONE                                       Date: 11/24/97  
Route: GAVAGE                                                                                                     Time: 11:24:36  
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         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      30 MG/KG     150                                       
                                                                                          MG/KG                                     
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            51          48          44          40                                       
     Total Primary Neoplasms                          139         125          89          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 50          45          40          39                                       
     Total Benign Neoplasms                           108         102          70          67                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          22          16           7                                       
     Total Malignant Neoplasms                         31          23          18           7                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           2                                                   
     Total Metastatic Neoplasm                                      1           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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