Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4408

TDMS Study 88034-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               OZONE


NTP Experiment-Test: 88034-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           10            9            9                                     
    Natural Death                                      6            3            6            1                                     
    Accidently Killed                                                            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           37           33           40                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (47)         (46)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (47)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Intestine Large, Rectum                            (49)         (43)         (45)         (45)                                   
   Intestine Large, Cecum                             (50)         (50)         (47)         (50)                                   
   Intestine Small, Duodenum                          (47)         (48)         (45)         (49)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (50)         (47)         (46)         (49)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (49)         (45)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                        14 (28%)      4 (8%)       5 (10%)      3 (6%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)                                                          
      Hepatocellular Adenoma                          13 (26%)     13 (26%)     12 (24%)      8 (16%)                               
      Hepatocellular Adenoma, Multiple                 7 (14%)      5 (10%)      5 (10%)                                            
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Mesentery                                          (11)         (4)          (4)          (1)                                    
      Carcinoma, Metastatic, Pancreas                  1 (9%)                                                                       
      Hemangiosarcoma                                  1 (9%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (9%)                                                                       
   Pancreas                                           (49)         (50)         (48)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (48)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (48)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Tongue                                                                                    (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
   Tooth                                              (1)          (1)                                                              
      Histiocytic Sarcoma                                           1 (100%)                                                        
      Odontoma                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Capsule, Adenoma                                                           1 (2%)                                             
      Capsule, Carcinoma                                                                      1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Benign                          2 (4%)       2 (4%)       3 (6%)                                             
   Islets, Pancreatic                                 (49)         (50)         (48)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (47)         (49)                                   
      Pars Distalis, Adenoma                          17 (34%)     13 (26%)     14 (30%)      9 (18%)                               
      Pars Intermedia, Adenoma                                      3 (6%)       2 (4%)       2 (4%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Follicular Cell, Carcinoma                       3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (50)         (48)         (50)                                   
      Cystadenoma                                      1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Luteoma                                                                                 1 (2%)                                
      Teratoma Benign                                                            1 (2%)                                             
      Bilateral, Cystadenoma                                        1 (2%)                                                          
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
      Hemangiosarcoma                                                            2 (4%)       2 (4%)                                
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Leiomyoma                                                                               1 (2%)                                
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    1 (2%)                                 5 (10%)                               
      Sarcoma Stromal                                  2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                    3 (6%)       1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (9)          (6)          (3)          (4)                                    
      Iliac, Histiocytic Sarcoma                                    1 (17%)                                                         
      Pancreatic, Histiocytic Sarcoma                               1 (17%)                                                         
      Renal, Histiocytic Sarcoma                                    1 (17%)                                                         
   Lymph Node, Bronchial                              (48)         (39)         (40)         (42)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Lymph Node, Mandibular                             (47)         (39)         (43)         (46)                                   
   Lymph Node, Mesenteric                             (49)         (49)         (46)         (47)                                   
      Carcinoma, Metastatic, Pancreas                  1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mediastinal                            (41)         (42)         (39)         (35)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (49)         (50)         (48)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       4 (8%)       2 (4%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Thymus                                             (47)         (49)         (46)         (47)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (48)         (49)                                   
      Carcinoma                                        1 (2%)                                 1 (2%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)                       (1)          (1)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (100%)                                                                     
      Sarcoma                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (49)         (50)                                   
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       5 (10%)      5 (10%)      7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)       5 (10%)      8 (16%)                               
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Uterus                                                     1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      2 (4%)       2 (4%)       2 (4%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
      Mediastinum, Hemangiosarcoma                     1 (2%)                                                                       
   Nose                                               (50)         (50)         (48)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   5                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (2)          (4)          (3)                                    
      Adenoma                                          1 (33%)                   3 (75%)      1 (33%)                               
      Carcinoma                                        2 (67%)      2 (100%)     1 (25%)      2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (48)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Lymphoma Malignant                               7 (14%)     17 (34%)     14 (28%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          44          42          40                                       
     Total Primary Neoplasms                           91          79          92          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 33          33          32          29                                       
     Total Benign Neoplasms                            50          47          53          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          28          28          26                                       
     Total Malignant Neoplasms                         41          32          39          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             13           4           3           4                                       
     Total Metastatic Neoplasm                         33           5           4           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10           19           20                                     
    Natural Death                                      4            6            6            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           34           25           27                                     
    Natural Death                                      1                                                                            
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (46)         (48)         (48)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)                                   
   Intestine Small, Duodenum                          (49)         (47)         (48)         (48)                                   
   Intestine Small, Jejunum                           (49)         (48)         (49)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (48)         (49)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               3 (6%)       1 (2%)                                             
      Hepatocellular Carcinoma                        10 (20%)      4 (8%)      11 (22%)     13 (26%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Hepatocellular Adenoma                           9 (18%)     17 (34%)     13 (26%)     12 (24%)                               
      Hepatocellular Adenoma, Multiple                14 (28%)      4 (8%)       6 (12%)      4 (8%)                                
   Mesentery                                          (4)          (5)          (1)          (3)                                    
      Carcinoma, Metastatic, Uncertain Primary Site    1 (25%)                                                                      
      Hemangiosarcoma                                               1 (20%)                                                         
   Pancreas                                           (49)         (50)         (50)         (50)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Stomach, Glandular                                 (50)         (49)         (50)         (50)                                   
   Tooth                                              (1)          (1)          (1)          (1)                                    
      Odontoma                                                      1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                                                                 1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Adenoma                                                       2 (4%)                    1 (2%)                                
   Pituitary Gland                                    (47)         (49)         (49)         (48)                                   
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
   Prostate                                           (49)         (50)         (47)         (49)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                    2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Mast Cell Tumor Benign                                                                  1 (2%)                                
   Lymph Node                                         (4)          (6)          (3)          (10)                                   
   Lymph Node, Bronchial                              (40)         (43)         (36)         (38)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (3%)                                             
   Lymph Node, Mandibular                             (41)         (43)         (41)         (38)                                   
   Lymph Node, Mesenteric                             (48)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Lymph Node, Mediastinal                            (40)         (48)         (39)         (45)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (3%)                                             
   Spleen                                             (49)         (50)         (49)         (50)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (39)         (42)         (37)         (41)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteoma                                                                    1 (2%)                                             
   Skeletal Muscle                                                              (1)          (1)                                    
      Hemangioma                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      9 (18%)      9 (18%)     10 (20%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                                     3 (6%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      2 (4%)       4 (8%)       8 (16%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      5 (10%)      2 (4%)       4 (8%)       2 (4%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (8)          (6)          (4)                                    
      Adenoma                                          1 (100%)     4 (50%)      3 (50%)      4 (100%)                              
      Carcinoma                                                     3 (38%)      3 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Urinary Bladder           1 (2%)                                                                       
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant                               4 (8%)       7 (14%)      4 (8%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 88034-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:38:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          43          42          40                                       
     Total Primary Neoplasms                           60          71          70          68                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 27          33          30          29                                       
     Total Benign Neoplasms                            33          43          39          35                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          25          24          27                                       
     Total Malignant Neoplasms                         27          28          31          33                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           3           4           2                                       
     Total Metastatic Neoplasm                         11           3           6           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------