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TDMS Study 88034-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               OZONE


NTP Experiment-Test: 88034-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56           56                                     
  Scheduled Sacrifice                                  6            6            6            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           22           17           16                                     
    Natural Death                                      3            4            3            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           24           30           27                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (49)                                   
   Intestine Large, Rectum                            (43)         (48)         (45)         (48)                                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (49)         (49)         (48)         (47)                                   
   Intestine Small, Ileum                             (50)         (49)         (48)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                        1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Mesentery                                          (4)          (5)          (11)         (4)                                    
      Sarcoma                                                                    1 (9%)                                             
   Oral Mucosa                                        (1)          (1)                                                              
      Pharyngeal, Squamous Cell Papilloma                           1 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (1)          (1)                       (1)                                    
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       2 (4%)       1 (2%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Ganglioneuroma                                                                          1 (2%)                                
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          5 (10%)      5 (10%)      5 (10%)      4 (8%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pars Distalis, Adenoma                          34 (68%)     36 (73%)     38 (76%)     33 (67%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                 1 (2%)                                
      C-Cell, Adenoma                                  4 (8%)       5 (10%)      5 (10%)      1 (2%)                                
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (50)         (47)         (47)                                   
      Adenoma                                          5 (12%)      3 (6%)       7 (15%)      8 (17%)                               
      Carcinoma                                                     3 (6%)       3 (6%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Bilateral, Adenoma                                                         1 (2%)                                             
   Ovary                                              (50)         (50)         (49)         (49)                                   
      Arrhenoblastoma Malignant                        1 (2%)                                                                       
      Granulosa Cell Tumor Malignant                                1 (2%)       1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Malignant                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Deciduoma Benign                                                                        1 (2%)                                
      Polyp Stromal                                    8 (16%)     11 (22%)      7 (14%)      6 (12%)                               
      Polyp Stromal, Multiple                          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Sarcoma Stromal, Multiple                        1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Lymph Node                                         (5)          (9)          (3)          (3)                                    
      Carcinoma, Metastatic, Thyroid Gland                          1 (11%)                                                         
      Iliac, Histiocytic Sarcoma                       1 (20%)                                                                      
      Pancreatic, Histiocytic Sarcoma                  1 (20%)                                                                      
   Lymph Node, Bronchial                              (43)         (39)         (36)         (43)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (3%)                                                          
   Lymph Node, Mandibular                             (48)         (47)         (46)         (46)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node, Mediastinal                            (39)         (46)         (41)         (47)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (3%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (45)         (43)         (46)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Thymoma Malignant                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                        4 (8%)       1 (2%)       3 (6%)       1 (2%)                                
      Fibroadenoma                                    18 (36%)     12 (24%)     22 (44%)      8 (16%)                               
      Fibroadenoma, Multiple                           2 (4%)       5 (10%)      1 (2%)       4 (8%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                               1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Melanoma Malignant                       1 (2%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)                                    (3)                                    
      Rhabdomyosarcoma                                                                        1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Glioma Benign                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                               2 (4%)                                             
      Carcinoma, Metastatic, Mammary Gland                                                    1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Glands, Adenoma                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            17 (34%)     18 (36%)     16 (32%)     17 (34%)                               
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Mesothelioma Malignant                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          48          46                                       
     Total Primary Neoplasms                          116         118         125          97                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          43          45          41                                       
     Total Benign Neoplasms                            86          87          96          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          28          26          23                                       
     Total Malignant Neoplasms                         30          31          29          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          3                       1                                       
     Total Metastatic Neoplasm                                     10                       1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56           56                                     
  Scheduled Sacrifice                                  6            6            6            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                35           40           36           36                                     
    Natural Death                                      6            5            7            7                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            5            7            7                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (49)                                   
   Intestine Large, Cecum                             (50)         (50)         (49)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
   Intestine Small, Jejunum                           (50)         (50)         (48)         (49)                                   
   Intestine Small, Ileum                             (50)         (50)         (49)         (48)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                           2 (4%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (12)         (6)          (12)         (8)                                    
      Histiocytic Sarcoma                                                        1 (8%)                                             
      Fat, Lipoma                                                                1 (8%)                                             
   Oral Mucosa                                        (1)          (1)                                                              
      Pharyngeal, Squamous Cell Papilloma              1 (100%)     1 (100%)                                                        
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tooth                                              (2)          (2)          (1)          (2)                                    
      Odontoma                                                                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          9 (18%)      8 (16%)     16 (32%)      7 (14%)                               
      Bilateral, Pheochromocytoma Benign               8 (16%)      9 (18%)      8 (16%)      9 (18%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          4 (8%)       2 (4%)       5 (10%)      5 (10%)                               
      Adenoma, Multiple                                                                       1 (2%)                                
      Carcinoma                                        3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
   Parathyroid Gland                                  (49)         (49)         (48)         (47)                                   
   Pituitary Gland                                    (50)         (50)         (49)         (49)                                   
      Pars Distalis, Adenoma                          41 (82%)     43 (86%)     42 (86%)     40 (82%)                               
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  1 (2%)       8 (16%)      2 (4%)       1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (49)         (50)         (50)         (49)                                   
      Adenoma                                          3 (6%)                    2 (4%)       2 (4%)                                
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
   Prostate                                           (49)         (50)         (50)         (50)                                   
      Adenoma                                                                    2 (4%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma            9 (18%)     14 (28%)     16 (32%)     22 (44%)                               
                                                             Page   9                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Interstitial Cell, Adenoma                      18 (36%)      9 (18%)     15 (30%)     10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (18)         (10)         (24)         (10)                                   
      Renal, Histiocytic Sarcoma                                                 1 (4%)                                             
   Lymph Node, Bronchial                              (43)         (38)         (44)         (38)                                   
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (46)         (46)         (42)                                   
   Lymph Node, Mesenteric                             (49)         (49)         (50)         (50)                                   
   Lymph Node, Mediastinal                            (46)         (47)         (48)         (46)                                   
      Squamous Cell Carcinoma, Metastatic, Lung        1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibroma                                          1 (2%)                                                                       
   Thymus                                             (44)         (43)         (45)         (41)                                   
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (29)         (28)         (30)                                   
      Carcinoma                                                                  1 (4%)                                             
      Fibroadenoma                                     2 (6%)       1 (3%)       2 (7%)       1 (3%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)                                                          
      Keratoacanthoma                                  2 (4%)       2 (4%)       2 (4%)       7 (14%)                               
      Keratoacanthoma, Multiple                        1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                    1 (2%)                                
      Trichoepithelioma                                                                       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)       4 (8%)       1 (2%)       3 (6%)                                
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                                                          
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chondrosarcoma                                   1 (2%)                                                                       
   Skeletal Muscle                                    (2)                       (2)          (1)                                    
      Squamous Cell Carcinoma, Metastatic, Lung        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Glioma Malignant                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (1)          (1)                                    
      Carcinoma                                                                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Adenoma                            2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Renal Tubule, Adenoma, Multiple                               1 (2%)                                                          
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            27 (54%)     31 (62%)     31 (62%)     27 (54%)                               
      Mesothelioma Benign                                           1 (2%)                    2 (4%)                                
      Mesothelioma Malignant                           2 (4%)                    1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 88034-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:53:31  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.12 PPM     0.5 PPM      1.0 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          49          49                                       
     Total Primary Neoplasms                          152         159         166         159                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47          48          49                                       
     Total Benign Neoplasms                           111         112         123         119                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          35          32          33                                       
     Total Malignant Neoplasms                         41          47          43          40                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1           1                                       
     Total Metastatic Neoplasm                          5           1           2           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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