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TDMS Study 88034-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 03                                                                                     TIME: 20:09:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: C88034       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 03                                                                                     TIME: 20:09:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: C88034       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 03                                                                                     TIME: 20:09:41       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: C88034       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                            IN THE ANALYSIS OF THE STUDY OF 6  OZONE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                             Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                            Keratoacanthoma
                                            Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
              Thyroid Gland: C-Cell         Adenoma
                                            Carcinoma or Adenoma
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Mammary Gland                 Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              ====================================================================================================
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   6.3%         0.0%        14.3%         0.0%      |   0.0%         4.2%         5.8%         3.7%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    0/7 (0%)   |  0/28 (0%)    1/24 (4%)    1/30 (3%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   681          ---          733 (T)      ---       |   ---          733 (T)      659          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.474N     P=0.477N     P=0.757N     P=0.541N   |  P=0.378      P=0.469      P=0.253      P=0.493    |
|INCIDENTAL TUMOR       |  P=0.458N     P=0.443N     P=0.756N     P=0.487N   |  P=0.381      P=0.469      P=0.268      P=0.493    |
|LOGISTIC REGRESSION    |  P=0.461N     P=0.496N     P=0.748N     P=0.501N   |  P=0.369      P=0.469      P=0.242      P=0.493    |
|COCHRAN-ARMITAGE       |  P=0.456N                                          |  P=0.373                                           |
|FISHER EXACT           |               P=0.500N     P=0.753N     P=0.500N   |               P=0.500      P=0.247      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/50 (34%)  17/50 (34%)  24/50 (48%)  16/50 (32%) |  6/50 (12%)   5/50 (10%)   6/50 (12%)   4/50 (8%)  |
|ADJUSTED (b)           |  83.0%        80.5%        94.2%        81.6%      |  19.7%        16.8%        17.3%        14.8%      |
|TERMINAL (d)           |  5/8 (63%)    2/5 (40%)    6/7 (86%)    4/7 (57%)  |  4/28 (14%)   2/24 (8%)    3/30 (10%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   606          605          442          526       |   688          568          665          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.506      P=0.498      P=0.191      P=0.549    |  P=0.338N     P=0.580N     P=0.568N     P=0.402N   |
|INCIDENTAL TUMOR       |  P=0.477N     P=0.541N     P=0.087      P=0.456N   |  P=0.340N     P=0.503N     P=0.538N     P=0.387N   |
|LOGISTIC REGRESSION    |  P=0.527      P=0.530N     P=0.093      P=0.514N   |  P=0.351N     P=0.533N     P=0.574N     P=0.408N   |
|COCHRAN-ARMITAGE       |  P=0.527                                           |  P=0.349N                                          |
|FISHER EXACT           |               P=0.583N     P=0.111      P=0.500N   |               P=0.500N     P=0.620N     P=0.370N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/50 (34%)  18/50 (36%)  25/50 (50%)  18/50 (36%) |  6/50 (12%)   6/50 (12%)   6/50 (12%)   4/50 (8%)  |
|ADJUSTED (b)           |  83.0%        81.4%        94.9%        83.9%      |  19.7%        18.6%        17.3%        14.8%      |
|TERMINAL (d)           |  5/8 (63%)    2/5 (40%)    6/7 (86%)    4/7 (57%)  |  4/28 (14%)   2/24 (8%)    3/30 (10%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   606          605          442          526       |   688          470          665          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.383      P=0.430      P=0.153      P=0.405    |  P=0.285N     P=0.541      P=0.568N     P=0.402N   |
|INCIDENTAL TUMOR       |  P=0.446      P=0.566      P=0.058      P=0.559    |  P=0.294N     P=0.605      P=0.538N     P=0.387N   |
|LOGISTIC REGRESSION    |  P=0.365      P=0.570      P=0.059      P=0.495    |  P=0.301N     P=0.609      P=0.574N     P=0.408N   |
|COCHRAN-ARMITAGE       |  P=0.380                                           |  P=0.293N                                          |
|FISHER EXACT           |               P=0.500      P=0.078      P=0.500    |               P=0.620N     P=0.620N     P=0.370N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/49 (6%)    0/50 (0%)    2/50 (4%)    2/49 (4%)  |  5/43 (12%)   3/50 (6%)    8/47 (17%)   8/47 (17%) |
|ADJUSTED (b)           |  24.5%         0.0%        18.4%         4.1%      |  21.6%        12.5%        24.9%        30.0%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     1/7 (14%)    0/7 (0%)   |  4/21 (19%)   3/24 (13%)   5/27 (19%)   6/24 (25%) |
|FIRST INCIDENCE (DAYS) |   676          ---          671          372       |   709          733 (T)      659          685       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.509      P=0.140N     P=0.475N     P=0.532N   |  P=0.112      P=0.301N     P=0.407      P=0.329    |
|INCIDENTAL TUMOR       |  P=0.480      P=0.112N     P=0.474N     P=0.585N   |  P=0.108      P=0.284N     P=0.438      P=0.341    |
|LOGISTIC REGRESSION    |  P=0.533      P=0.113N     P=0.462N     P=0.514N   |  P=0.092      P=0.277N     P=0.418      P=0.315    |
|COCHRAN-ARMITAGE       |  P=0.531                                           |  P=0.098                                           |
|FISHER EXACT           |               P=0.117N     P=0.490N     P=0.500N   |               P=0.276N     P=0.336      P=0.336    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    1/50 (2%)    0/50 (0%)    1/49 (2%)  |  0/43 (0%)    3/50 (6%)    3/47 (6%)    1/47 (2%)  |
|ADJUSTED (b)           |   2.2%         3.6%         0.0%         4.5%      |   0.0%        12.5%        11.1%         4.2%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/21 (0%)    3/24 (13%)   3/27 (11%)   1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |   498          639          ---          653       |   ---          733 (T)      733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.595N     P=0.757      P=0.509N     P=0.747N   |  P=0.567N     P=0.143      P=0.167      P=0.527    |
|INCIDENTAL TUMOR       |  P=0.597N     P=0.756N     P=0.443N     P=0.716    |  P=0.567N     P=0.143      P=0.167      P=0.527    |
|LOGISTIC REGRESSION    |  P=0.601N     P=0.758N     P=0.493N     P=0.747    |  P=0.567N     P=0.143      P=0.167      P=0.527    |
|COCHRAN-ARMITAGE       |  P=0.593N                                          |  P=0.597N                                          |
|FISHER EXACT           |               P=0.747N     P=0.495N     P=0.753N   |               P=0.151      P=0.138      P=0.522    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/49 (8%)    1/50 (2%)    2/50 (4%)    3/49 (6%)  |  5/43 (12%)   5/50 (10%)  11/47 (23%)   9/47 (19%) |
|ADJUSTED (b)           |  26.2%         3.6%        18.4%         8.5%      |  21.6%        20.8%        35.2%        33.9%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     1/7 (14%)    0/7 (0%)   |  4/21 (19%)   5/24 (21%)   8/27 (30%)   7/24 (29%) |
|FIRST INCIDENCE (DAYS) |   498          639          671          372       |   709          733 (T)      659          685       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.536      P=0.205N     P=0.322N     P=0.518N   |  P=0.107      P=0.567N     P=0.172      P=0.240    |
|INCIDENTAL TUMOR       |  P=0.513      P=0.173N     P=0.294N     P=0.605N   |  P=0.103      P=0.549N     P=0.187      P=0.249    |
|LOGISTIC REGRESSION    |  P=0.556      P=0.170N     P=0.320N     P=0.523N   |  P=0.085      P=0.545N     P=0.173      P=0.222    |
|COCHRAN-ARMITAGE       |  P=0.557                                           |  P=0.093                                           |
|FISHER EXACT           |               P=0.175N     P=0.329N     P=0.500N   |               P=0.530N     P=0.118      P=0.246    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/50 (4%)    5/50 (10%)   6/50 (12%) |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  15.1%         6.1%        49.8%        35.0%      |   0.0%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     3/7 (43%)    1/7 (14%)  |  0/28 (0%)    1/24 (4%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   578          591          625          621       |   ---          733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.156      P=0.312N     P=0.498      P=0.370    |  P=0.457N     P=0.469        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.220      P=0.362N     P=0.417      P=0.465    |  P=0.457N     P=0.469        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.148      P=0.337N     P=0.511      P=0.378    |  P=0.457N     P=0.469        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.148                                           |  P=0.467N                                          |
|FISHER EXACT           |               P=0.339N     P=0.500      P=0.370    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    2/50 (4%)    2/50 (4%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  17.8%        27.7%        21.4%        18.6%      |   3.6%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  1/8 (13%)    1/5 (20%)    1/7 (14%)    1/7 (14%)  |  1/28 (4%)    1/24 (4%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   565          639          715          658       |   733 (T)      733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.358N     P=0.611      P=0.517N     P=0.524N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.314N     P=0.581      P=0.560N     P=0.469N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.359N     P=0.656N     P=0.489N     P=0.495N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.357N                                          |  P=0.214N                                          |
|FISHER EXACT           |               P=0.661N     P=0.500N     P=0.500N   |               P=0.753N     P=0.500N     P=0.505N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/50 (14%)   5/50 (10%)   7/50 (14%)   8/50 (16%) |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  30.2%        32.2%        65.5%        48.5%      |   3.6%         8.3%         0.0%         0.0%      |
|TERMINAL (d)           |  1/8 (13%)    1/5 (20%)    4/7 (57%)    2/7 (29%)  |  1/28 (4%)    2/24 (8%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   565          591          625          621       |   733 (T)      733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.319      P=0.399N     P=0.600      P=0.481    |  P=0.131N     P=0.446      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.421      P=0.463N     P=0.510      P=0.601    |  P=0.131N     P=0.446      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.311      P=0.374N     P=0.602N     P=0.512    |  P=0.131N     P=0.446      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.314                                           |  P=0.142N                                          |
|FISHER EXACT           |               P=0.380N     P=0.613N     P=0.500    |               P=0.500      P=0.500N     P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    2/50 (4%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  18.0%        38.3%        22.9%         8.3%      |   3.6%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  1/8 (13%)    1/5 (20%)    1/7 (14%)    0/7 (0%)   |  1/28 (4%)    1/24 (4%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   681          709          722          695       |   733 (T)      733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.266N     P=0.406      P=0.684N     P=0.548N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.494      P=0.688N     P=0.501N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.275N     P=0.474      P=0.667N     P=0.514N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |  P=0.211N                                          |
|FISHER EXACT           |               P=0.500      P=0.691N     P=0.500N   |               P=0.753N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    2/50 (4%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  18.0%        38.3%        22.9%         8.3%      |   3.6%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  1/8 (13%)    1/5 (20%)    1/7 (14%)    0/7 (0%)   |  1/28 (4%)    1/24 (4%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   681          709          722          695       |   733 (T)      733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.266N     P=0.406      P=0.684N     P=0.548N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.494      P=0.688N     P=0.501N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.275N     P=0.474      P=0.667N     P=0.514N   |  P=0.203N     P=0.728      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |  P=0.211N                                          |
|FISHER EXACT           |               P=0.500      P=0.691N     P=0.500N   |               P=0.753N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.1%         8.3%         4.2%         0.0%      |   0.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/28 (0%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   606          698          654          ---       |   ---          611          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.175N     P=0.479N     P=0.470N     P=0.275N   |  P=0.454N     P=0.500        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.157N     P=0.449N     P=0.491N     P=0.203N   |  P=0.511N     P=0.602        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.164N     P=0.495N     P=0.500N     P=0.235N   |  P=0.443N     P=0.512        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.166N                                          |  P=0.464N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.247N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.1%         8.3%         4.2%         3.1%      |   0.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/28 (0%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   606          698          654          616       |   ---          611          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.447N     P=0.479N     P=0.470N     P=0.531N   |  P=0.454N     P=0.500        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.396N     P=0.449N     P=0.491N     P=0.430N   |  P=0.511N     P=0.602        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.425N     P=0.495N     P=0.500N     P=0.498N   |  P=0.443N     P=0.512        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.429N                                          |  P=0.464N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.1%         8.3%         4.2%         3.1%      |   0.0%         2.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/28 (0%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   606          698          654          616       |   ---          611          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.447N     P=0.479N     P=0.470N     P=0.531N   |  P=0.454N     P=0.500        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.396N     P=0.449N     P=0.491N     P=0.430N   |  P=0.511N     P=0.602        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.425N     P=0.495N     P=0.500N     P=0.498N   |  P=0.443N     P=0.512        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.429N                                          |  P=0.464N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.2%        16.4%        20.4%        25.4%      |   0.0%         0.0%         6.4%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    1/7 (14%)  |  0/28 (0%)    0/24 (0%)    1/30 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   514          537          698          619       |   ---          ---          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.271      P=0.474      P=0.504      P=0.302    |  P=0.550        (e)        P=0.258        (e)      |
|INCIDENTAL TUMOR       |  P=0.224      P=0.558      P=0.539      P=0.290    |  P=0.547        (e)        P=0.268        (e)      |
|LOGISTIC REGRESSION    |  P=0.246      P=0.500      P=0.501      P=0.309    |  P=0.545        (e)        P=0.255        (e)      |
|COCHRAN-ARMITAGE       |  P=0.244                                           |  P=0.544                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.309    |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    3/50 (6%)    4/50 (8%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |  14.4%        18.6%        33.7%        30.1%      |   0.0%         0.0%         6.4%         0.0%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     2/7 (29%)    1/7 (14%)  |  0/28 (0%)    0/24 (0%)    1/30 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   514          537          698          619       |   ---          ---          723          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.301      P=0.454      P=0.479      P=0.307    |  P=0.550        (e)        P=0.258        (e)      |
|INCIDENTAL TUMOR       |  P=0.281      P=0.491      P=0.506      P=0.318    |  P=0.547        (e)        P=0.268        (e)      |
|LOGISTIC REGRESSION    |  P=0.284      P=0.500      P=0.515      P=0.341    |  P=0.545        (e)        P=0.255        (e)      |
|COCHRAN-ARMITAGE       |  P=0.283                                           |  P=0.544                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.339    |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  4/50 (8%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%        14.3%         0.0%      |  14.3%         4.2%         8.1%         3.7%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    0/7 (0%)   |  4/28 (14%)   1/24 (4%)    1/30 (3%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      ---       |   733 (T)      733 (T)      536          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.658        (e)        P=0.473        (e)      |  P=0.237N     P=0.225N     P=0.461N     P=0.187N   |
|INCIDENTAL TUMOR       |  P=0.658        (e)        P=0.473        (e)      |  P=0.247N     P=0.225N     P=0.526N     P=0.187N   |
|LOGISTIC REGRESSION    |  P=0.658        (e)        P=0.473        (e)      |  P=0.251N     P=0.223N     P=0.484N     P=0.187N   |
|COCHRAN-ARMITAGE       |  P=0.655                                           |  P=0.249N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.181N     P=0.500N     P=0.181N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  5/50 (10%)   2/50 (4%)    4/50 (8%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%        14.3%         0.0%      |  17.9%         8.3%        10.4%         3.7%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    0/7 (0%)   |  5/28 (18%)   2/24 (8%)    1/30 (3%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          733 (T)      ---       |   733 (T)      733 (T)      536          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.658        (e)        P=0.473        (e)      |  P=0.139N     P=0.278N     P=0.459N     P=0.108N   |
|INCIDENTAL TUMOR       |  P=0.658        (e)        P=0.473        (e)      |  P=0.144N     P=0.278N     P=0.506N     P=0.108N   |
|LOGISTIC REGRESSION    |  P=0.658        (e)        P=0.473        (e)      |  P=0.148N     P=0.278N     P=0.483N     P=0.108N   |
|COCHRAN-ARMITAGE       |  P=0.655                                           |  P=0.148N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.218N     P=0.500N     P=0.102N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  | 20/50 (40%)  17/50 (34%)  23/50 (46%)  12/50 (24%) |
|ADJUSTED (b)           |  21.3%         8.3%        28.6%         2.9%      |  54.6%        57.1%        59.6%        40.4%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     2/7 (29%)    0/7 (0%)   | 12/28 (43%)  12/24 (50%)  15/30 (50%)  10/27 (37%) |
|FIRST INCIDENCE (DAYS) |   715          698          733 (T)      611       |   571          596          536          512       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453N     P=0.569N     P=0.682      P=0.501N   |  P=0.092N     P=0.533N     P=0.461      P=0.099N   |
|INCIDENTAL TUMOR       |  P=0.453N     P=0.487N     P=0.682      P=0.477N   |  P=0.094N     P=0.366N     P=0.444      P=0.079N   |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.520N     P=0.686N     P=0.505N   |  P=0.099N     P=0.393N     P=0.414      P=0.078N   |
|COCHRAN-ARMITAGE       |  P=0.475N                                          |  P=0.102N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500N   |               P=0.339N     P=0.343      P=0.066N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  | 21/50 (42%)  18/50 (36%)  24/50 (48%)  12/50 (24%) |
|ADJUSTED (b)           |  21.3%         8.3%        28.6%         2.9%      |  57.5%        60.6%        60.6%        40.4%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     2/7 (29%)    0/7 (0%)   | 13/28 (46%)  13/24 (54%)  15/30 (50%)  10/27 (37%) |
|FIRST INCIDENCE (DAYS) |   715          698          733 (T)      611       |   571          596          536          512       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453N     P=0.569N     P=0.682      P=0.501N   |  P=0.063N     P=0.545N     P=0.465      P=0.069N   |
|INCIDENTAL TUMOR       |  P=0.453N     P=0.487N     P=0.682      P=0.477N   |  P=0.061N     P=0.379N     P=0.454      P=0.052N   |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.520N     P=0.686N     P=0.505N   |  P=0.065N     P=0.400N     P=0.416      P=0.052N   |
|COCHRAN-ARMITAGE       |  P=0.475N                                          |  P=0.069N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500N   |               P=0.341N     P=0.344      P=0.044N*  |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  | 23/50 (46%)  19/50 (38%)  25/50 (50%)  13/50 (26%) |
|ADJUSTED (b)           |  21.3%         8.3%        28.6%         2.9%      |  63.1%        64.2%        63.3%        43.9%      |
|TERMINAL (d)           |  1/8 (13%)    0/5 (0%)     2/7 (29%)    0/7 (0%)   | 15/28 (54%)  14/24 (58%)  16/30 (53%)  11/27 (41%) |
|FIRST INCIDENCE (DAYS) |   715          698          733 (T)      611       |   571          596          536          512       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453N     P=0.569N     P=0.682      P=0.501N   |  P=0.046N*    P=0.485N     P=0.544      P=0.048N*  |
|INCIDENTAL TUMOR       |  P=0.453N     P=0.487N     P=0.682      P=0.477N   |  P=0.043N*    P=0.317N     P=0.545      P=0.035N*  |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.520N     P=0.686N     P=0.505N   |  P=0.047N*    P=0.328N     P=0.513      P=0.035N*  |
|COCHRAN-ARMITAGE       |  P=0.475N                                          |  P=0.053N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500N   |               P=0.272N     P=0.421      P=0.030N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.1%         3.4%         0.0%         0.0%      |   3.6%         5.7%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  1/28 (4%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   462          625          ---          ---       |   733 (T)      664          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.219N     P=0.759N     P=0.513N     P=0.504N   |  P=0.144N     P=0.463      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.209N     P=0.758      P=0.443N     P=0.581N   |  P=0.134N     P=0.504      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.224N     P=0.760N     P=0.497N     P=0.603N   |  P=0.141N     P=0.495      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.211N                                          |  P=0.140N                                          |
|FISHER EXACT           |               P=0.753N     P=0.500N     P=0.500N   |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.1%         3.4%         0.0%         0.0%      |   3.6%         5.7%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  1/28 (4%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   462          625          ---          ---       |   733 (T)      664          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.219N     P=0.759N     P=0.513N     P=0.504N   |  P=0.144N     P=0.463      P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.209N     P=0.758      P=0.443N     P=0.581N   |  P=0.134N     P=0.504      P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.224N     P=0.760N     P=0.497N     P=0.603N   |  P=0.141N     P=0.495      P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.211N                                          |  P=0.140N                                          |
|FISHER EXACT           |               P=0.753N     P=0.500N     P=0.500N   |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 41/50 (82%)  43/50 (86%)  42/49 (86%)  40/49 (82%) | 34/50 (68%)  36/49 (73%)  38/50 (76%)  33/49 (67%) |
|ADJUSTED (b)           |  94.3%       100.0%       100.0%        95.1%      |  86.7%        94.5%        88.3%        88.8%      |
|TERMINAL (d)           |  6/8 (75%)    5/5 (100%)   7/7 (100%)   5/7 (71%)  | 23/28 (82%)  22/24 (92%)  25/30 (83%)  22/26 (85%) |
|FIRST INCIDENCE (DAYS) |   462          441          387          422       |   502          469          536          571       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.464N     P=0.412      P=0.544N     P=0.531    |  P=0.423N     P=0.168      P=0.463      P=0.485    |
|INCIDENTAL TUMOR       |  P=0.254N     P=0.511      P=0.510      P=0.335N   |  P=0.519N     P=0.248      P=0.378      P=0.522    |
|LOGISTIC REGRESSION    |  P=0.378N     P=0.392      P=0.363      P=0.487N   |  P=0.517N     P=0.277      P=0.359      P=0.504    |
|COCHRAN-ARMITAGE       |  P=0.452N                                          |  P=0.450N                                          |
|FISHER EXACT           |               P=0.393      P=0.410      P=0.584N   |               P=0.353      P=0.252      P=0.558N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 41/50 (82%)  44/50 (88%)  42/49 (86%)  40/49 (82%) | 34/50 (68%)  36/49 (73%)  38/50 (76%)  33/49 (67%) |
|ADJUSTED (b)           |  94.3%       100.0%       100.0%        95.1%      |  86.7%        94.5%        88.3%        88.8%      |
|TERMINAL (d)           |  6/8 (75%)    5/5 (100%)   7/7 (100%)   5/7 (71%)  | 23/28 (82%)  22/24 (92%)  25/30 (83%)  22/26 (85%) |
|FIRST INCIDENCE (DAYS) |   462          441          387          422       |   502          469          536          571       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.439N     P=0.369      P=0.544N     P=0.531    |  P=0.423N     P=0.168      P=0.463      P=0.485    |
|INCIDENTAL TUMOR       |  P=0.196N     P=0.382      P=0.510      P=0.335N   |  P=0.519N     P=0.248      P=0.378      P=0.522    |
|LOGISTIC REGRESSION    |  P=0.323N     P=0.282      P=0.363      P=0.487N   |  P=0.517N     P=0.277      P=0.359      P=0.504    |
|COCHRAN-ARMITAGE       |  P=0.396N                                          |  P=0.450N                                          |
|FISHER EXACT           |               P=0.288      P=0.410      P=0.584N   |               P=0.353      P=0.252      P=0.558N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |                                                    |
|ADJUSTED (b)           |   0.0%         0.0%        20.9%         0.0%      |                                                    |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    0/7 (0%)   |                                                    |
|FIRST INCIDENCE (DAYS) |   ---          ---          701          ---       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.551        (e)        P=0.243        (e)      |                                                    |
|INCIDENTAL TUMOR       |  P=0.542        (e)        P=0.244        (e)      |                                                    |
|LOGISTIC REGRESSION    |  P=0.542        (e)        P=0.254        (e)      |                                                    |
|COCHRAN-ARMITAGE       |  P=0.546                                           |                                                    |
|FISHER EXACT           |                 (e)        P=0.253        (e)      |                                                    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    2/50 (4%)    9/50 (18%) |  2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |  37.5%        33.4%        10.5%        50.7%      |   7.1%         4.2%         0.0%         7.4%      |
|TERMINAL (d)           |  3/8 (38%)    1/5 (20%)    0/7 (0%)     1/7 (14%)  |  2/28 (7%)    1/24 (4%)    0/30 (0%)    2/27 (7%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      591          669          526       |   733 (T)      733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.030 *    P=0.365      P=0.509N     P=0.055    |  P=0.588      P=0.554N     P=0.223N     P=0.683    |
|INCIDENTAL TUMOR       |  P=0.029 *    P=0.384      P=0.503N     P=0.053    |  P=0.588      P=0.554N     P=0.223N     P=0.683    |
|LOGISTIC REGRESSION    |  P=0.027 *    P=0.506      P=0.457N     P=0.053    |  P=0.588      P=0.554N     P=0.223N     P=0.683    |
|COCHRAN-ARMITAGE       |  P=0.031 *                                         |  P=0.571                                           |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.061    |               P=0.500N     P=0.247N     P=0.691N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    1/50 (2%)    3/50 (6%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.0%        40.6%        11.1%        22.4%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     1/5 (20%)    0/7 (0%)     1/7 (14%)  |  1/28 (4%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   715          681          723          621       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.478      P=0.149      P=0.727N     P=0.278    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.475      P=0.218      P=0.722N     P=0.330    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.457      P=0.162      P=0.746N     P=0.299    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.470                                           |  P=0.345N                                          |
|FISHER EXACT           |               P=0.181      P=0.753N     P=0.309    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  15
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    6/50 (12%)   1/50 (2%)    3/50 (6%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.0%        43.6%        11.1%        22.4%      |   3.6%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     1/5 (20%)    0/7 (0%)     1/7 (14%)  |  1/28 (4%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   715          489          723          621       |   733 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.495N     P=0.053      P=0.727N     P=0.278    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|INCIDENTAL TUMOR       |  P=0.499N     P=0.075      P=0.722N     P=0.330    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|LOGISTIC REGRESSION    |  P=0.504N     P=0.060      P=0.746N     P=0.299    |  P=0.338N     P=0.531N     P=0.486N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.505N                                          |  P=0.345N                                          |
|FISHER EXACT           |               P=0.056      P=0.753N     P=0.309    |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.9%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/28 (0%)    0/24 (0%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          489          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277N     P=0.254        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.277N     P=0.236        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.297N     P=0.240        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.280N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  16
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    7/50 (14%) |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  37.5%         7.5%        10.5%        39.0%      |   0.0%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  3/8 (38%)    0/5 (0%)     0/7 (0%)     1/7 (14%)  |  0/28 (0%)    1/24 (4%)    0/30 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      591          669          526       |   ---          733 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.042 *    P=0.605N     P=0.509N     P=0.131    |  P=0.457N     P=0.469        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.050 *    P=0.616N     P=0.503N     P=0.138    |  P=0.457N     P=0.469        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.048 *    P=0.492N     P=0.457N     P=0.152    |  P=0.457N     P=0.469        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.050 *                                         |  P=0.464N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.159    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    2/50 (4%)    8/50 (16%) |  2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  37.5%        33.4%        10.5%        44.6%      |   7.1%         4.2%         0.0%         3.7%      |
|TERMINAL (d)           |  3/8 (38%)    1/5 (20%)    0/7 (0%)     1/7 (14%)  |  2/28 (7%)    1/24 (4%)    0/30 (0%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      591          669          526       |   733 (T)      733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.058      P=0.365      P=0.509N     P=0.084    |  P=0.358N     P=0.554N     P=0.223N     P=0.513N   |
|INCIDENTAL TUMOR       |  P=0.061      P=0.384      P=0.503N     P=0.087    |  P=0.359N     P=0.554N     P=0.223N     P=0.513N   |
|LOGISTIC REGRESSION    |  P=0.058      P=0.506      P=0.457N     P=0.092    |  P=0.359N     P=0.554N     P=0.223N     P=0.513N   |
|COCHRAN-ARMITAGE       |  P=0.064                                           |  P=0.373N                                          |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.100    |               P=0.500N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  17
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    2/50 (4%)    8/50 (16%) |  1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  37.5%        16.8%        10.5%        44.6%      |   3.6%         4.2%         0.0%         3.7%      |
|TERMINAL (d)           |  3/8 (38%)    0/5 (0%)     0/7 (0%)     1/7 (14%)  |  1/28 (4%)    1/24 (4%)    0/30 (0%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      591          669          526       |   733 (T)      733 (T)      ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.036 *    P=0.568      P=0.509N     P=0.084    |  P=0.580N     P=0.728      P=0.486N     P=0.754    |
|INCIDENTAL TUMOR       |  P=0.037 *    P=0.591      P=0.503N     P=0.087    |  P=0.580N     P=0.728      P=0.486N     P=0.754    |
|LOGISTIC REGRESSION    |  P=0.036 *    P=0.660N     P=0.457N     P=0.092    |  P=0.580N     P=0.728      P=0.486N     P=0.754    |
|COCHRAN-ARMITAGE       |  P=0.039 *                                         |  P=0.591N                                          |
|FISHER EXACT           |               P=0.661N     P=0.500N     P=0.100    |               P=0.753N     P=0.500N     P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  23/50 (46%)  31/50 (62%)  32/50 (64%) |                                                    |
|ADJUSTED (b)           | 100.0%        84.1%        88.9%        95.9%      |                                                    |
|TERMINAL (d)           |  8/8 (100%)   2/5 (40%)    4/7 (57%)    6/7 (86%)  |                                                    |
|FIRST INCIDENCE (DAYS) |   462          537          442          372       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.128      P=0.401N     P=0.383      P=0.220    |                                                    |
|INCIDENTAL TUMOR       |  P=0.101      P=0.283N     P=0.309      P=0.280    |                                                    |
|LOGISTIC REGRESSION    |  P=0.065      P=0.226N     P=0.252      P=0.235    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.060                                           |                                                    |
|FISHER EXACT           |               P=0.274N     P=0.272      P=0.208    |                                                    |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  18
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    8/50 (16%)   2/50 (4%)    1/50 (2%)  |  5/50 (10%)   5/50 (10%)   5/50 (10%)   2/50 (4%)  |
|ADJUSTED (b)           |   2.4%        44.4%        15.2%         2.6%      |  15.8%        19.4%        16.7%         5.4%      |
|TERMINAL (d)           |  0/8 (0%)     1/5 (20%)    0/7 (0%)     0/7 (0%)   |  3/28 (11%)   4/24 (17%)   5/30 (17%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   543          441          697          583       |   667          681          733 (T)      648       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.105N     P=0.022 *    P=0.540      P=0.740N   |  P=0.148N     P=0.534      P=0.591N     P=0.246N   |
|INCIDENTAL TUMOR       |  P=0.102N     P=0.024 *    P=0.591      P=0.749    |  P=0.143N     P=0.581      P=0.572N     P=0.218N   |
|LOGISTIC REGRESSION    |  P=0.100N     P=0.019 *    P=0.510      P=0.744    |  P=0.157N     P=0.586      P=0.583N     P=0.230N   |
|COCHRAN-ARMITAGE       |  P=0.100N                                          |  P=0.159N                                          |
|FISHER EXACT           |               P=0.017 *    P=0.508      P=0.747N   |               P=0.630N     P=0.630N     P=0.218N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.6%        16.7%        16.3%         3.4%      |   0.0%         4.0%         6.7%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     1/7 (14%)    0/7 (0%)   |  0/28 (0%)    0/24 (0%)    2/30 (7%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   674          653          520          621       |   ---          727          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.434N     P=0.346      P=0.497      P=0.725    |  P=0.581N     P=0.477      P=0.253        (e)      |
|INCIDENTAL TUMOR       |  P=0.411N     P=0.438      P=0.547      P=0.715N   |  P=0.586N     P=0.519      P=0.253        (e)      |
|LOGISTIC REGRESSION    |  P=0.402N     P=0.320      P=0.508      P=0.755N   |  P=0.590N     P=0.479      P=0.253        (e)      |
|COCHRAN-ARMITAGE       |  P=0.407N                                          |  P=0.591N                                          |
|FISHER EXACT           |               P=0.316      P=0.508      P=0.747N   |               P=0.500      P=0.247        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  19
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/49 (4%)   11/50 (22%)   4/50 (8%)    2/50 (4%)  |  5/50 (10%)   6/50 (12%)   7/50 (14%)   2/50 (4%)  |
|ADJUSTED (b)           |   7.9%        53.7%        29.0%         5.9%      |  15.8%        22.6%        23.3%         5.4%      |
|TERMINAL (d)           |  0/8 (0%)     1/5 (20%)    1/7 (14%)    0/7 (0%)   |  3/28 (11%)   4/24 (17%)   7/30 (23%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   543          441          520          583       |   667          681          733 (T)      648       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.106N     P=0.015 *    P=0.365      P=0.679    |  P=0.150N     P=0.401      P=0.423      P=0.246N   |
|INCIDENTAL TUMOR       |  P=0.092N     P=0.018 *    P=0.432      P=0.670N   |  P=0.145N     P=0.455      P=0.441      P=0.218N   |
|LOGISTIC REGRESSION    |  P=0.088N     P=0.010 **   P=0.348      P=0.694    |  P=0.159N     P=0.447      P=0.434      P=0.230N   |
|COCHRAN-ARMITAGE       |  P=0.090N                                          |  P=0.162N                                          |
|FISHER EXACT           |               P=0.008 **   P=0.349      P=0.684N   |               P=0.500      P=0.380      P=0.218N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |  12.5%        24.2%         4.8%         2.6%      |   3.6%         4.2%         5.3%         3.7%      |
|TERMINAL (d)           |  1/8 (13%)    1/5 (20%)    0/7 (0%)     0/7 (0%)   |  1/28 (4%)    1/24 (4%)    1/30 (3%)    1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      678          671          583       |   733 (T)      733 (T)      378          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.510N     P=0.410      P=0.759N     P=0.758    |  P=0.581      P=0.728      P=0.516      P=0.754    |
|INCIDENTAL TUMOR       |  P=0.457N     P=0.431      P=0.748N     P=0.746N   |  P=0.565      P=0.728      P=0.415      P=0.754    |
|LOGISTIC REGRESSION    |  P=0.480N     P=0.488      P=0.745N     P=0.755N   |  P=0.576      P=0.728      P=0.506      P=0.754    |
|COCHRAN-ARMITAGE       |  P=0.479N                                          |  P=0.571                                           |
|FISHER EXACT           |               P=0.508      P=0.747N     P=0.747N   |               P=0.753N     P=0.500      P=0.753N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  20
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 10/50 (20%)  12/50 (24%)   8/50 (16%)   7/50 (14%) |
|ADJUSTED (b)           |                                                    |  32.4%        36.9%        23.2%        22.5%      |
|TERMINAL (d)           |                                                    |  8/28 (29%)   6/24 (25%)   5/30 (17%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |                                                    |   665          611          613          654       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.133N     P=0.291      P=0.337N     P=0.340N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.142N     P=0.395      P=0.326N     P=0.314N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.144N     P=0.365      P=0.337N     P=0.330N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.142N                                          |
|FISHER EXACT           |                                                    |               P=0.405      P=0.398N     P=0.298N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 11/50 (22%)  12/50 (24%)   8/50 (16%)   7/50 (14%) |
|ADJUSTED (b)           |                                                    |  33.9%        36.9%        23.2%        22.5%      |
|TERMINAL (d)           |                                                    |  8/28 (29%)   6/24 (25%)   5/30 (17%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |                                                    |   527          611          613          654       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.102N     P=0.378      P=0.254N     P=0.260N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.111N     P=0.481      P=0.280N     P=0.241N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.110N     P=0.472      P=0.268N     P=0.242N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.106N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.306N     P=0.218N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  21
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  31/50 (62%)  31/50 (62%)  27/50 (54%) | 17/50 (34%)  18/50 (36%)  16/50 (32%)  17/50 (34%) |
|ADJUSTED (b)           |  94.9%        95.4%        95.1%        79.9%      |  42.6%        45.0%        40.8%        43.6%      |
|TERMINAL (d)           |  7/8 (88%)    4/5 (80%)    6/7 (86%)    3/7 (43%)  |  7/28 (25%)   5/24 (21%)   8/30 (27%)   7/27 (26%) |
|FIRST INCIDENCE (DAYS) |   514          441          264          502       |   443          541          378          434       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.449N     P=0.235      P=0.346      P=0.515    |  P=0.471N     P=0.399      P=0.424N     P=0.509    |
|INCIDENTAL TUMOR       |  P=0.378N     P=0.248      P=0.263      P=0.496N   |  P=0.490      P=0.524N     P=0.511N     P=0.516    |
|LOGISTIC REGRESSION    |  P=0.406N     P=0.276      P=0.265      P=0.554N   |  P=0.491      P=0.561N     P=0.506N     P=0.575N   |
|COCHRAN-ARMITAGE       |  P=0.426N                                          |  P=0.480N                                          |
|FISHER EXACT           |               P=0.272      P=0.272      P=0.579N   |               P=0.500      P=0.500N     P=0.583N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    5/50 (10%) |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.0%         2.6%         5.0%        22.2%      |   0.0%         0.0%         3.3%         0.0%      |
|TERMINAL (d)           |  0/8 (0%)     0/5 (0%)     0/7 (0%)     0/7 (0%)   |  0/28 (0%)    0/24 (0%)    1/30 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   462          574          678          583       |   ---          ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.067      P=0.507N     P=0.472N     P=0.227    |  P=0.662        (e)        P=0.514        (e)      |
|INCIDENTAL TUMOR       |  P=0.083      P=0.470N     P=0.424N     P=0.253    |  P=0.662        (e)        P=0.514        (e)      |
|LOGISTIC REGRESSION    |  P=0.065      P=0.499N     P=0.500N     P=0.214    |  P=0.662        (e)        P=0.514        (e)      |
|COCHRAN-ARMITAGE       |  P=0.066                                           |  P=0.655                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.218    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  22
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/50 (96%)  47/50 (94%)  48/50 (96%)  49/50 (98%) | 41/50 (82%)  43/50 (86%)  45/50 (90%)  41/50 (82%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  97.6%       100.0%        97.8%        95.3%      |
|TERMINAL (d)           |  8/8 (100%)   5/5 (100%)   7/7 (100%)   7/7 (100%) | 27/28 (96%)  24/24 (100%) 29/30 (97%)  25/27 (93%) |
|FIRST INCIDENCE (DAYS) |   462          441          387          372       |   502          469          378          512       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.430      P=0.529      P=0.487N     P=0.440    |  P=0.427N     P=0.150      P=0.497      P=0.453    |
|INCIDENTAL TUMOR       |  P=0.520N     P=0.257N     P=0.443N     P=0.419N   |  P=0.467      P=0.345      P=0.342      P=0.477    |
|LOGISTIC REGRESSION    |  P=0.431      P=0.467N     P=0.731      P=0.806    |  P=0.467      P=0.327      P=0.304      P=0.467    |
|COCHRAN-ARMITAGE       |  P=0.280                                           |  P=0.512N                                          |
|FISHER EXACT           |               P=0.500N     P=0.691N     P=0.500    |               P=0.393      P=0.194      P=0.602N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  35/50 (70%)  32/50 (64%)  33/50 (66%) | 26/50 (52%)  28/50 (56%)  26/50 (52%)  23/50 (46%) |
|ADJUSTED (b)           |  95.7%        96.1%        95.7%        92.3%      |  60.1%        68.5%        61.1%        55.9%      |
|TERMINAL (d)           |  7/8 (88%)    4/5 (80%)    6/7 (86%)    5/7 (71%)  | 12/28 (43%)  12/24 (50%)  14/30 (47%)  10/27 (37%) |
|FIRST INCIDENCE (DAYS) |   359          441          264          502       |   443          470          378          275       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.464N     P=0.361      P=0.482N     P=0.497    |  P=0.256N     P=0.295      P=0.461N     P=0.449N   |
|INCIDENTAL TUMOR       |  P=0.431N     P=0.397      P=0.496N     P=0.553    |  P=0.294N     P=0.459      P=0.476      P=0.401N   |
|LOGISTIC REGRESSION    |  P=0.417N     P=0.418      P=0.502N     P=0.567N   |  P=0.316N     P=0.431      P=0.564      P=0.403N   |
|COCHRAN-ARMITAGE       |  P=0.437N                                          |  P=0.223N                                          |
|FISHER EXACT           |               P=0.415      P=0.500N     P=0.583N   |               P=0.421      P=0.579N     P=0.345N   |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 03                                                 PAGE  23
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |   CONTROL      0.12 PPM     0.5 PPM      1.0 PPM   |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  49/50 (98%)  49/50 (98%)  49/50 (98%) | 48/50 (96%)  48/50 (96%)  48/50 (96%)  46/50 (92%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  98.0%       100.0%       100.0%        97.9%      |
|TERMINAL (d)           |  8/8 (100%)   5/5 (100%)   7/7 (100%)   7/7 (100%) | 27/28 (96%)  24/24 (100%) 30/30 (100%) 26/27 (96%) |
|FIRST INCIDENCE (DAYS) |   359          441          264          372       |   443          469          378          275       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.503      P=0.483      P=0.487N     P=0.485    |  P=0.335N     P=0.268      P=0.364N     P=0.559    |
|INCIDENTAL TUMOR       |  P=0.338N     P=0.638N     P=0.649N     P=0.419N   |  P=0.491N     P=0.718N     P=0.748N     P=0.595N   |
|LOGISTIC REGRESSION    |  P=0.410N     P=0.638N     P=0.777      P=0.555N   |  P=0.531N     P=0.660      P=0.675      P=0.588N   |
|COCHRAN-ARMITAGE       |  P=0.627                                           |  P=0.217N                                          |
|FISHER EXACT           |               P=0.753N     P=0.753N     P=0.753N   |               P=0.691N     P=0.691N     P=0.339N   |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).