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TDMS Study 88034-03 Pathology Tables

NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  I  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X  X     X     X        X  X  X     X  X  X  X  X  X  X  X      |             
      Clear Cell Focus                     |                                  X              X                 X      |             
      Degeneration, Fatty                  |                2     2     2  3                    1                 2  2|             
      Eosinophilic Focus                   |          X                                                     X         |             
      Hepatodiaphragmatic Nodule           |                      X                             X  X                 X|             
      Mixed Cell Focus                     |    X     X                             X                                 |             
      Necrosis                             |                            2                                             |             
      Bile Duct, Hyperplasia               |                2                    2                 2  1  1            |             
      Centrilobular, Necrosis              |                                     2                 2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
      Pharyngeal, Hyperplasia              |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2        1           3  1  2     3     1     1              2  1     1   |             
      Basophilic Focus                     | X                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                   X      |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2  1                             1               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2  1  1     1  1  2     2     1           1  1  2  1     1  2  1|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        1        1     1                       1           2            |             
      Hypertrophy                          | 2              2        2                                                |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2           1        1  2                             2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2           3                    1        1         |             
      Pars Distalis, Hyperplasia           |                2  2  3        2  2  1                 3        2  2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        1  1  1  2  1  2  1  1  1  1  2     1  1  2  1  2  1  1  2  2  1|             
      Follicular Cell, Hyperplasia         |    2                                                              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +     +  +  +  +  +  +  +  +  +  +  M     +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                        2                                 |             
      Inflammation, Granulomatous          |                                                 3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +                       +              +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M     +  +  +  +  M  +  +  +  +  +  M     M  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M  +  +  +  M  +  +  +  +  +     M  +  +  M  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                            3                                             |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  M  +  +  +  +  +  +     +  M  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Atypical                |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |             2                                                            |             
      Prepuce, Inflammation, Acute         |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Meninges, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                            3                                             |             
      Mineralization                       |                            2                                             |             
      Epiglottis, Metaplasia, Squamous     |             1                          4                                 |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            1                                   2         |             
      Mineralization                       |                            2                                             |             
      Alveolar Epithelium, Hyperplasia     |                               2                    1     1               |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1                                                         |             
      Thrombosis                           |                1     1     3        1                                    |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Lateral Wall, Hyperplasia            |                            2                                             |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 3| 6| 0| 3| 3| 6| 3| 0| 3| 2| 3| 3| 8| 3| 0| 0| 3| 3| 0| 3| 3| 9| 3| 8| 0|             
                                           | 4| 7| 2| 4| 4| 6| 5| 9| 3| 7| 7| 5| 7| 3| 2| 9| 3| 3| 3| 3| 5| 5| 4| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1     2  1  1  1  2  2  1  1  1  1  1     2  1  2  2  2  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                            3                                             |             
      Mineralization                       |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                       2                  |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  1     2  2  1  2  1  3  1  1  2  1  3     1  3  3  1  2  3  2  1  2  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I  +  +  +  +  +  +  +  +  +  +  +  +  I     I  +  I  +  I  +  +  +     +|             
      Parasite Metazoan                    |                   X        X                          X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                         X           X                 X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X     X        X     X  X  X     X  X  X  X  X  X  X  X     X|             
      Clear Cell Focus                     |                                     X                             X     X|             
      Degeneration, Fatty                  |    1        3                 2              1           2               |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hepatodiaphragmatic Nodule           |                                              X           X               |             
      Mixed Cell Focus                     |                X                       X                                 |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |             1     1           1                       1                  |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +           +                          +               |             
      Hemorrhage                           |                   2                                                      |             
      Artery, Inflammation, Chronic Active |                                                          4               |             
      Artery, Mineralization               |                                                          4               |             
      Fat, Necrosis                        |    2                          3                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Atrophy                              | 2              2  1        2  2  1     1           2  2           2      |             
      Basophilic Focus                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Diverticulum                         |                                                                          |             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Mineralization                       |                                                          4        1      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Aorta, Mineralization                |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy                       | 2  2     2     2  2     2  1     1  1  2        2  1  1  3  3  2  1     1|             
      Artery, Mineralization               |                                                          4               |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |       2  3     3  2        2     2  4  2     1  2     3  1  1     2      |             
      Hypertrophy                          |       2  2        2              2  2  2     2  1                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                2  2                                         1  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +     +|             
      Hyperplasia                          |                   2                                      3               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                      1                                                   |             
      Pars Distalis, Hyperplasia           |          2                                            3           2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  | 2  2  2  2  1  1  2  1        1  1  2  2     2     2  2  1        1     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |          2                                                               |             
      Cyst                                 |                                                                          |             
      Inflammation, Granulomatous          |                                                       4                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +     M  M  +  +  +  +  +  +     +|             
      Hemorrhage                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Fibrosis                             |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                      4                                                   |             
      Hemorrhage                           |                                                 3                        |             
      Necrosis                             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Atypical                |                                                       2        3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hyperkeratosis                       |             3                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Fibrous Osteodystrophy               |                                                          4               |             
      Hyperostosis                         |                   3                    3                    2            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Hemorrhage                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                                              1                           |             
      Meninges, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                4                                         4               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |       1                 1                          1                     |             
      Mineralization                       |                                                          4               |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
      Artery, Mediastinum, Mineralization  |                                                          4               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                                    1     1               |             
      Thrombosis                           |             1                 2                                          |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                    2                     |             
      Lateral Wall, Hyperplasia            |                                                          2               |             
      Lateral Wall, Metaplasia, Squamous   |                                                          3        2      |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 0| 3| 3| 4| 7| 0| 5| 3| 3| 3| 0| 3| 3| 3| 3| 8| 6| 3| 3| 0| 3|             
                                           | 5| 3| 3| 3| 9| 4| 5| 6| 1| 8| 3| 5| 5| 3| 2| 0| 5| 3| 3| 8| 5| 5| 4| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  1  1  2  1  2  1  1  1  1  2  2  2     2  2  2  2  2  1  1  2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                          4               |             
      Nephropathy                          | 3  3  2  1  2  3  3  1  1  2  1  2  3  3     3  3  2  3  4  4  3  3     3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  I  +        +                                                         |  43        |
      Parasite Metazoan                    | X                                                                        |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +                                                         |  50        |
      Angiectasis                          | 1                                                                        |      1  1.0|
      Basophilic Focus                     | X  X                                                                     |     38     |
      Clear Cell Focus                     |                                                                          |      6     |
      Degeneration, Fatty                  |                3                                                         |     13  2.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                X                                                         |      7     |
      Mixed Cell Focus                     |                                                                          |      5     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                2                                                         |     10  1.4|
      Centrilobular, Necrosis              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +                                                         |  50        |
      Atrophy                              |                1                                                         |     22  1.6|
      Basophilic Focus                     |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +                                                         |  50        |
      Atrophy                              |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +                                                         |  50        |
      Diverticulum                         |                                                                          |      1     |
      Necrosis                             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +                                                         |  50        |
      Mineralization                       |                                                                          |      5  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +                                                         |  50        |
      Cardiomyopathy                       | 2  2           1                                                         |     37  1.6|
      Artery, Mineralization               |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +        +                                                         |  50        |
      Hyperplasia                          | 1                                                                        |     21  1.8|
      Hypertrophy                          | 1                                                                        |     12  1.8|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +        +                                                         |  50        |
      Hyperplasia                          |                                                                          |      9  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +        +                                                         |  49        |
      Hyperplasia                          |    2                                                                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +                                                         |  50        |
      Cyst                                 |                                                                          |      5  1.6|
      Pars Distalis, Hyperplasia           |                2                                                         |     13  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +                                                         |  50        |
      C-Cell, Hyperplasia                  | 1  2           1                                                         |     43  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +        +                                                         |  43        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +        +                                                         |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +        +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +                                                         |  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +        +                                                         |  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +        +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +        +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M        +                                                         |  39        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +                                                         |  50        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +        +                                                         |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +                                                         |  50        |
      Hyperplasia, Atypical                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +                                                         |  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Prepuce, Inflammation, Acute         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Hyperostosis                         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +                                                         |  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Meninges, Hyperplasia                | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +        +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 3| 6| 6| 4|                                                        |            |
                             DAY ON TEST   | 3| 3| 6| 0| 0| 4|                                                        |            |
                                           | 5| 3| 2| 2| 2| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Epiglottis, Metaplasia, Squamous     |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      5  1.2|
      Mineralization                       |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.5|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +                                                         |  50        |
      Inflammation, Suppurative            |                                                                          |      3  1.0|
      Thrombosis                           |                                                                          |      6  1.5|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Lateral Wall, Hyperplasia            |                                                                          |      2  2.0|
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      2  2.5|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  1  1        2                                                         |     50  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +                                                         |  50        |
      Infarct                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Nephropathy                          | 4  2           2                                                         |     49  2.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Parasite Metazoan                    |             X                                         X              X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Basophilic Focus                     |          X  X        X     X        X     X     X  X  X  X  X  X  X     X|             
      Clear Cell Focus                     |          X                                                              X|             
      Degeneration, Fatty                  |                4                                               3         |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                       X  X           X      |             
      Mixed Cell Focus                     |             X        X     X                 X        X              X   |             
      Bile Duct, Hyperplasia               |                               1           2  1                           |             
      Centrilobular, Necrosis              |                                           1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                          +        +              +                     |             
      Fat, Necrosis                        | 2                          2        2              2                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                            +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                 1           1     1     1     2  2        1   |             
      Basophilic Focus                     |                                                 X                        |             
      Metaplasia, Hepatocyte               |                                           1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                3                                               3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             1              2              1                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        1  1     1        1     1        1  2  1  2  1  1     1  2  1   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        2           2     2     2           2  1     3  1     1  1  3  1|             
      Hypertrophy                          | 2        1                 1                       3        1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                             2                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +     +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 2              4                          4              1               |             
      Pars Intermedia, Hyperplasia         |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     2  1  1     1     2  2  2     1     3  2     1     2     1  1  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             4              3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Inflammation, Granulomatous   |                                     1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +  +  +  M     +  M  M  M  +  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                    2                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  M  +  +  +     +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                  2                                      2|             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3                                                        3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                                          2  4            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2                                                               |             
      Alveolar Epithelium, Metaplasia      |             1                                         1           1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            1                                1            |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                3                 2                                       |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                            1                                            1|             
      Lateral Wall, Hyperplasia            |                            1     2        2                             1|             
      Lateral Wall, Metaplasia, Squamous   |          1                 1     2        2                             1|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1     2  2  1  1  1     1  1  1     1  1  2  1  1  1  1  1  1  1     2|             
      Olfactory Epithelium, Metaplasia     |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Degeneration                         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    2     2  2  2  2  2     3  2  1  1  2  1  2  3  2  2  2  3  3  3  2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 6| 7| 7| 5| 6| 7| 6| 6| 5| 6| 4| 6| 5| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 0| 3| 3| 7| 2| 3| 0| 6| 9| 1| 7| 0| 6| 3| 3| 7| 3| 3| 3| 8| 3| 3| 3|             
                                           | 6| 9| 2| 4| 4| 9| 8| 4| 2| 7| 6| 1| 0| 0| 8| 5| 5| 7| 5| 3| 3| 1| 3| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  I     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |             1                                                            |             
      Basophilic Focus                     | X  X  X  X  X           X  X     X  X  X  X  X  X  X        X     X      |             
      Clear Cell Focus                     |             X              X                 X                           |             
      Degeneration, Fatty                  |                                           4     2                       3|             
      Eosinophilic Focus                   |                                                             X            |             
      Hepatodiaphragmatic Nodule           |    X                                      X                              |             
      Mixed Cell Focus                     |    X  X     X        X              X              X        X            |             
      Bile Duct, Hyperplasia               |       1     2                 3                 1     1  2           3   |             
      Centrilobular, Necrosis              |             1                                            1           2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |          2           1     2                             1           2   |             
      Basophilic Focus                     |                                                                          |             
      Metaplasia, Hepatocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Necrosis                             |                                           3                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                           1              3        2  2   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Developmental Malformation           |          X                                                               |             
      Inflammation, Chronic Active         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 1  1  1     2        1  2  2     2     1  1     2  2  1     1     1      |             
      Atrium, Thrombosis                   |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 2     2     1           2           1  2     1     2                     |             
      Hypertrophy                          |          2           1     2     1        3     2        1              3|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |       1     1                    1                 2        2     3  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                   3  2   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  | 2  3  1  1  2           2  2     2  1  2  2  1  1  2     2        3  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Chronic Active         |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                            2                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia, Reticulum Cell          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +              +                 +           +  +  +|             
      Renal, Hemorrhage                    |                                     2                                    |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +        +  +  +  +  M  +  M  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +        +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Plasma Cell   |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                                                    3              3      |             
      Necrosis                             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  M  +  +  +  +  +     M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M|             
      Galactocele                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperkeratosis                       |                                                       3                  |             
      Inflammation, Chronic Active         |                                     2                             3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Necrosis                             |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                      3                                                   |             
      Epiglottis, Metaplasia, Squamous     |                      4                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
      Inflammation, Suppurative            |                      3                                                   |             
      Alveolar Epithelium, Hyperplasia     |       1                                         1                       1|             
      Alveolar Epithelium, Metaplasia      |                            1     1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Suppurative            |             1        2                                   2               |             
      Necrosis                             |                                                          3               |             
      Thrombosis                           |                                                          3               |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Lateral Wall, Hyperplasia            |             1        2                 1                 2               |             
      Lateral Wall, Metaplasia, Squamous   |             1        1           1     1           2                     |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  1  1  1        1  1  2  1  1  1  1  1  2  1  1  1  1  2     1  1  1|             
      Olfactory Epithelium, Metaplasia     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Nephropathy                          | 2  2  2  1  3        3  3  2     3  3  4  2  2  2  2  1  2  2     1  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 3| 0| 0| 2| 3| 3| 7| 3| 0| 3| 2| 3| 0| 3| 4| 0| 3| 0| 3| 6| 1|             
                                           | 3| 9| 4| 3| 5| 2| 2| 7| 5| 4| 5| 4| 2| 3| 2| 4| 8| 3| 1| 1| 5| 2| 7| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +  I                                                         |  48        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +                                                         |  49        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | X     X     X  X                                                         |     34     |
      Clear Cell Focus                     |                                                                          |      5     |
      Degeneration, Fatty                  |          3                                                               |      6  3.2|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      6     |
      Mixed Cell Focus                     |                                                                          |     13     |
      Bile Duct, Hyperplasia               |          1                                                               |     11  1.6|
      Centrilobular, Necrosis              |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Necrosis                        |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +                                                         |  50        |
      Atrophy                              |       1                                                                  |     14  1.4|
      Basophilic Focus                     |                                                                          |      1     |
      Metaplasia, Hepatocyte               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +                                                         |  50        |
      Necrosis                             |          3                                                               |      4  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +                                                         |  50        |
      Mineralization                       |                1                                                         |      4  1.3|
      Necrosis                             |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +                                                         |  50        |
      Cardiomyopathy                       |             1  1                                                         |     32  1.3|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +  +                                                         |  50        |
      Hyperplasia                          |             2                                                            |     22  1.7|
      Hypertrophy                          |                                                                          |     13  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +  +  +                                                         |  50        |
      Hyperplasia                          |          2                                                               |     10  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +                                                         |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +                                                         |  49        |
      Pars Distalis, Hyperplasia           |          2     2                                                         |      8  2.5|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  |       1  1     2                                                         |     38  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +                                                         |  50        |
      Cyst                                 |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +                                                         |  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   9        |
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Inflammation, Granulomatous   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     M  M  +  +                                                         |  39        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  +                                                         |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +                                                         |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +                                                         |  50        |
      Fibrosis                             |                                                                          |      4  2.5|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M  +  M  +                                                         |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +                                                         |  49        |
      Galactocele                          |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +                                                         |  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +                                                         |  50        |
      Hyperostosis                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +                                                         |  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Epiglottis, Metaplasia, Squamous     | 3              1                                                         |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                1                                                         |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      5  1.4|
      Alveolar Epithelium, Metaplasia      |                                                                          |      6  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |       2                                                                  |      6  1.5|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      3  2.7|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 0| 6| 8| 3| 3|                                                        |            |
                                           | 3| 2| 7| 3| 4| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Hyperplasia                      |                                                                          |      2  1.0|
      Lateral Wall, Hyperplasia            |                                                                          |      8  1.5|
      Lateral Wall, Metaplasia, Squamous   |       2                                                                  |     11  1.4|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2     2  1  2  1                                                         |     48  1.2|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +                                                         |  50        |
      Nephropathy                          | 3     1  1  2  2                                                         |     48  2.1|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +                                                         |  49        |
      Hemorrhage                           |          3                                                               |      1  3.0|
      Necrosis                             |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  I  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                   X                       X  X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Basophilic Focus                     | X  X        X  X  X     X  X     X     X  X  X  X     X  X  X        X  X|             
      Clear Cell Focus                     |                                              X                       X   |             
      Degeneration, Fatty                  |          2  2              2                       2                     |             
      Hepatodiaphragmatic Nodule           |                                           X              X           X   |             
      Mixed Cell Focus                     |                                     X                                X   |             
      Necrosis                             |                                  2                                       |             
      Bile Duct, Hyperplasia               | 2  1        1              2  1                 2                        |             
      Centrilobular, Necrosis              | 2                                               1                        |             
      Serosa, Fibrosis                     |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +        +           +  +                              |             
      Artery, Inflammation, Chronic Active |    2                                                                     |             
      Fat, Necrosis                        |                   2        2           2  2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |             1           1              1  1           2  2  1           1|             
      Basophilic Focus                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Squamous                |          2                                                               |             
      Mineralization                       |                                                             1            |             
      Necrosis                             |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Mineralization                       |                                                             2            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Developmental Malformation           |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cardiomyopathy                       | 1        2              1     2  2  3  1  2  2  3  1  1  2  1  1     2  2|             
      Atrium, Thrombosis                   |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                         1  2  2  1  2  1  3              2  1        2  2|             
      Hypertrophy                          |                2  2     2              2        2                       3|             
      Vacuolization Cytoplasmic            |                                              2  2                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |          3                 2              1  2        2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +     +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |    3        3                          2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  |                   2     2  1  3  2  1  2  2  1  2  2  1        2     1  1|             
      Follicular Cell, Hyperplasia         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  I     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                      4   |             
      Inflammation, Chronic Active         |             3                                      3                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |          3                       2  2  3  2     3  1                     |             
      Inflammation, Granulomatous          |                         3                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                          +                                             |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +     +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +     +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +     M  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Fibrosis                             |    2                       2                                             |             
      Hematopoietic Cell Proliferation     |                                                             2  3         |             
      Capsule, Fibrosis                    |                                              1                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 6| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 9| 1| 3| 2| 5| 0| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 9| 0| 3| 3|             
                                           | 5| 3| 2| 0| 7| 3| 4| 0| 7| 9| 4| 3| 3| 3| 5| 4| 3| 0| 9| 4| 4| 8| 2| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia, Atypical                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                               1        2                                2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperostosis                         |                   2                             2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Epiglottis, Metaplasia, Squamous     |    2                                                  4                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
      Alveolar Epithelium, Metaplasia      | 2  1     2  1  1  2  2  1  2  2  2  2  2  1  2  2     2  2  2  2     2  1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2  1  1  1     1  1  1  2  2  1     2  1        1  1        1   |             
      Interstitium, Fibrosis               | 1        1  1  1  1        1  2  2  2  2     2  2     1  2  2  2     2  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Suppurative            |                   1                                                      |             
      Thrombosis                           |             4                                   1                        |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2     2     2  2     2  1  2  2  2  2  1  2  2     2  1  1  2     1  2|             
      Lateral Wall, Hyperplasia            | 2  2     2     2  2  2  2  2  3  2  1  2  1  2  3     2  1  1  2     2  2|             
      Lateral Wall, Metaplasia, Squamous   | 1           3  1     3  2  1                    2     2        3         |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2     1  1  1  3  1  2  2  2  2  2  2  2  1  1  1  3  1  2  3     2  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  3     1     3  3     2  2  3  3  4  3  4  3  1  2  1  2  3  1     2  3|             
      Renal Tubule, Hyperplasia            |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  I     +  I  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     I  +|             
      Parasite Metazoan                    |          X     X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |          X              X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Basophilic Focus                     | X  X     X  X     X     X  X  X                 X        X  X        X  X|             
      Clear Cell Focus                     | X                                                        X               |             
      Degeneration, Fatty                  |                      3                 2              2                  |             
      Hepatodiaphragmatic Nodule           |          X                                                              X|             
      Mixed Cell Focus                     |             X              X           X                                 |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |    2                                                  3                  |             
      Centrilobular, Necrosis              |                                        2                                 |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                               +  +     +           +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |    2                                                  3     2           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Atrophy                              |             1  2     1                 1              1     2            |             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                               1                                          |             
      Necrosis                             |                      3                                4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Mineralization                       |             1                 1                                          |             
      Necrosis                             |                                        2              3                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Cardiomyopathy                       | 1        2     2  1  1  1  1  1        2              2  2     1     2  1|             
      Atrium, Thrombosis                   |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                   1                    2        1  2        4  2     2  4|             
      Hypertrophy                          |             1     2                 1                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia                          |    2     1  2                                   1     2  1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  M  +  +  +  +  +  M  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia                          |    1                                            2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Cyst                                 |                                        1                                 |             
      Pars Distalis, Hyperplasia           |                      3                                      2  2        2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  |    1     2  1  1  1  2  2           2           1  2     1     1     4  1|             
      Follicular Cell, Hyperplasia         |                               1                          1              2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +  +  +  +  +  M  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
      Cyst                                 |                1           2  3                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     M  +  +  +  M  +  +  M  M  +  +        +  +  +  +  +  +     +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +  +  +  M        +  +  +  +  +  +     M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hemorrhage                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     M  M  M  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hemorrhage                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 3| 5| 5| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 5| 0| 3| 5| 3| 3| 3| 7| 3| 9| 0| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3|             
                                           | 3| 3| 2| 3| 3| 2| 5| 3| 4| 4| 5| 8| 6| 1| 2| 2| 3| 5| 9| 5| 3| 4| 2| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperplasia, Atypical                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Hyperostosis                         |                                                 1     2              4   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Epiglottis, Metaplasia, Squamous     |    1     1              1  4                                             |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Alveolar Epithelium, Hyperplasia     | 2                                                        1               |             
      Alveolar Epithelium, Metaplasia      | 2  1     1  1  1  1  2  2  2  2  2     2        2  2  1  2  2  1     2  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1           1           1     1                 1  1     1  1        1  1|             
      Interstitium, Fibrosis               | 2  1     1  1  1  1  2  1  1  1        1        1  1     2  1  1     2  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                        1              1                  |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 1  2     2  2  1  2  1  2  1  2  1  1           2  2     1  1  2     1  2|             
      Lateral Wall, Hyperplasia            | 1  2     2  2  1  2  2  2  1  1  1  2  1        2  2  3  2  1  2     3  1|             
      Lateral Wall, Metaplasia, Squamous   | 1                    1  1  2           3        1  2  1        1         |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2     2  3  2  2  2  1  2  2  1  3  2        2  2  3  2  3  2     2  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  3     3  3  1  2  1  3  2  3  1  3  1        3  1  2  3  2  2     2  3|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +  M  +  +        +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |       X        X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  45        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    | X     X        X                                                         |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Basophilic Focus                     |    X  X  X  X  X                                                         |     35     |
      Clear Cell Focus                     |    X                                                                     |      5     |
      Degeneration, Fatty                  |          3                                                               |      8  2.3|
      Hepatodiaphragmatic Nodule           |                X                                                         |      6     |
      Mixed Cell Focus                     |       X                                                                  |      6     |
      Necrosis                             |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      8  1.8|
      Centrilobular, Necrosis              |                                                                          |      3  1.7|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  11        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Necrosis                        |          3                                                               |      9  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |    1  1  2  2                                                            |     18  1.3|
      Basophilic Focus                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Necrosis                             |          4                                                               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       | 2              2                                                         |      5  1.6|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       |    2  1     1                                                            |     34  1.6|
      Atrium, Thrombosis                   |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |       1     2  2                                                         |     22  1.9|
      Hypertrophy                          |                                                                          |      9  1.9|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  46        |
      Hyperplasia                          |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  |    1  1  1  1  2                                                         |     34  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +                                                         |  47        |
      Hyperplasia                          | 2                                                                        |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  49        |
      Cyst                                 |             2                                                            |     11  2.2|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   3        |
      Renal, Inflammation, Granulomatous   | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  M  M  +                                                         |  36        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  +                                                         |  41        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +                                                         |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia, Atypical                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Hyperostosis                         | 3                                                                        |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
      Epiglottis, Metaplasia, Squamous     |    3     2     3                                                         |      9  2.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar Epithelium, Hyperplasia     |       2     2                                                            |      5  1.8|
      Alveolar Epithelium, Metaplasia      | 2  2  2  2  2  2                                                         |     48  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  2  1  1  1  1                                                         |     31  1.2|
      Interstitium, Fibrosis               | 1  2  2  1  1  1                                                         |     42  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |       1                                                                  |      2  1.0|
      Thrombosis                           |                                                                          |      4  1.8|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 2  2  1  2  2  2                                                         |     45  1.7|
      Lateral Wall, Hyperplasia            | 2  2  1  2  2  2                                                         |     48  1.8|
      Lateral Wall, Metaplasia, Squamous   | 2  3     1                                                               |     21  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 3| 6| 3| 3|                                                        |            |
                                           | 8| 3| 5| 5| 5| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  3  2  2  2                                                         |     50  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |             2                                                            |      1  2.0|
      Nephropathy                          | 2  2  4  3  2  3                                                         |     48  2.4|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Cyst                                 | 3                                                                        |             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  I  +  +  +  I  +  +        +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                           X           X|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X     X  X  X  X  X  X  X     X  X           X  X     X  X  X     X  X   |             
      Clear Cell Focus                     |             X  X  X                                      X               |             
      Degeneration, Fatty                  |    3                 2           1                                       |             
      Eosinophilic Focus                   |                      X                                                   |             
      Hepatodiaphragmatic Nodule           | X              X     X        X                                      X  X|             
      Mixed Cell Focus                     |                X                             X        X                 X|             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |    2     1                    2                             1            |             
      Centrilobular, Necrosis              |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                    +                                   +   |             
      Artery, Inflammation, Chronic Active |                                  3                                       |             
      Fat, Necrosis                        |             3                                                        2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Atrophy                              |    2     2        1                                   1     2     4      |             
      Basophilic Focus                     |                                                                   X      |             
      Artery, Inflammation                 |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                | 3                                                                        |             
      Necrosis                             |    3                 4                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                  2                                       |             
      Mineralization                       | 2                                               1        1  1            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Developmental Malformation           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     1  2  2  3  2              2  1           2     1  1  1     2  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  2     2  2     2                    1  2     2     2        2   |             
      Hypertrophy                          |       2  2                                                               |             
      Mineralization                       |                                                                          |             
      Necrosis                             | 2                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                               2     2        1  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  M  +  +  +  +  +|             
      Hyperplasia                          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    4                                                                 2  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1  2  1  1     2           1           2  2     1  1  2        1   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  I  +  +  +  +  +  +  +        +  +     +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           | 4                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                            1                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  M  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 3                                                              2         |             
      Hemorrhage                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 2                                                                        |             
      Hyperostosis                         |             4        3                                      4     4      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +  +      |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Meninges, Hyperplasia                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    4                                                                     |             
      Epiglottis, Metaplasia, Squamous     | 2  4  2  1  1  3  3  2  2        2  3           1     2  4  2  2        2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                      1   |             
      Alveolar Epithelium, Metaplasia      | 3  3  2  3  2  2  3  4  3  2  2  3           3  3     3  3  3  3  3  3  3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  2  1  1  2  2  2  3  2  1     2              2     2  2  1  2  2  2  1|             
      Interstitium, Fibrosis               | 2  2  2  2  1  2  2  3  2  1     2           2  2     2  2  2  3  2  3  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    3                                         1                           |             
      Thrombosis                           |    4                                                                     |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2  3  2  2  2  2  2  3  2  3  3  1        3  2     3  3  3  2  2  3  3|             
      Lateral Wall, Hyperplasia            | 2  2  2  2  3  2  3  2  2  2  2  3  2        2  3     3  3  3  3  3  3  2|             
      Lateral Wall, Metaplasia, Squamous   | 2  3  2  2  2  2  2  3  3  2  2  2  1        1  2     3  2     3  2  2  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  3  4  3  3  4  4  4  2        4  2        3  3     3  4  3  1  3  4  4|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 1| 5| 7| 4| 6| 6| 6| 7| 6| 7| 7| 7| 2| 7| 7| 6|             
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 1| 8| 8| 7| 3| 6| 0| 0| 8| 3| 0| 3| 3| 3| 7| 3| 3| 5|             
                                           | 5| 8| 3| 5| 5| 4| 5| 5| 3| 3| 1| 5| 3| 2| 2| 5| 5| 2| 3| 3| 3| 5| 5| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cataract                             |             3                                                            |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Nephropathy                          | 4  1  2  2  2  2  2  2  2        4  1        2  3     2  2  3     2  2  2|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
      Cyst                                 |                                                                          |             
      Parasite Metazoan                    |          X           X        X                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Parasite Metazoan                    |                      X        X                    X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Angiectasis                          |                         1     2                       2                 1|             
      Basophilic Focus                     | X  X  X  X        X  X  X              X  X  X  X  X           X  X     X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |             1                                                            |             
      Eosinophilic Focus                   |                   X                                                      |             
      Hepatodiaphragmatic Nodule           | X  X     X                       X  X  X        X                 X      |             
      Mixed Cell Focus                     |                                        X                       X  X      |             
      Regeneration                         |                                  2                                       |             
      Bile Duct, Hyperplasia               |    1        2  2     2           2                             1         |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                                   3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
      Atrophy                              |    1  2     2  2  1  1  3        2  1     2  2                           |             
      Basophilic Focus                     |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Diverticulum                         |                                                    X                     |             
      Hyperplasia, Squamous                |                                                                          |             
      Necrosis                             |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                   1                          1                           |             
      Necrosis                             |                2                 1                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
      Hyperplasia                          |             3                                                            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Cardiomyopathy                       |    2  1              1              1     2  1     2  2        2  2     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia                          |       2                       2     3  2     2        1           2     1|             
      Hypertrophy                          |                      2        3                                          |             
      Mineralization                       |                                     2                                    |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Pars Distalis, Hyperplasia           |             2  2              2  2                 2              4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      C-Cell, Hyperplasia                  | 2     2           2  2  3           1  1  2  2  1  1              1     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                              3     3                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     A  +  +     +|             
      Cyst                                 |             3                                                            |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia, Reticulum Cell          |                                                    2              2     1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                 +                                          |             
      Renal, Hemorrhage                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +     M  +  +  +  M  +  +  +  +     M  +  M     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     M|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     M  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         | 4                       3                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Meninges, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Epiglottis, Metaplasia, Squamous     | 1  3  1  2  3  2  2  1  3     4  1  4  3  2  2     2  3        4  3     1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                 1                          1                           |             
      Alveolar Epithelium, Metaplasia      | 3  2  3  2  3  2  3  3  3     3  3  2  3  3  3  3  3  2        3  3     3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     2  1        2  2  2     2  2  1  2  2  1  2  2  1        2  2     2|             
      Interstitium, Fibrosis               | 2  1  2  1  2  2  2  2  2     3  3  2  2  2  2  2  2  2        2  2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |             1  2                                                         |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 3  3  2  3  2  2  2  3  2     3  3  3  3  2  2  3  3  2     2  2  3     2|             
      Lateral Wall, Hyperplasia            | 3  2  2  3  3  2  3  3  2     3  3  3  3  3  3  3  3  2     2  3  2     3|             
      Lateral Wall, Metaplasia, Squamous   | 2  2     2  1  2  2     2     1  2  1  3     1  2  2  1     1  2  2      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  1  3  4  2  3  4  4  2     3  3  3  4  4  3  3  4  3        3  3     3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 5| 7| 7| 6| 6| 5| 4| 7| 6| 7| 7| 6| 7| 6| 6| 0| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 6| 3| 1| 6| 2| 3| 3| 3| 0| 1| 3| 3| 5| 3| 3| 4| 3| 8| 0| 5| 3| 3| 0| 3|             
                                           | 7| 8| 5| 6| 5| 6| 5| 4| 6| 2| 2| 4| 4| 4| 5| 4| 1| 3| 3| 2| 0| 4| 5| 2| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                        4                                 |             
      Retina, Atrophy                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
      Cyst                                 |    4                                                                     |             
      Hemorrhage                           |    4                                                                     |             
      Nephropathy                          | 3  1  2  2  2  2  2  3  3     1  1  3  2  2  3  1  2  2        3  3     3|             
      Renal Tubule, Hyperplasia            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
      Cyst                                 |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |       X  X                                                               |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      4  1.5|
      Basophilic Focus                     | X  X  X  X  X  X                                                         |     38     |
      Clear Cell Focus                     |                                                                          |      4     |
      Degeneration, Fatty                  |                                                                          |      4  1.8|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           | X                                                                        |     15     |
      Mixed Cell Focus                     |                                                                          |      7     |
      Regeneration                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |       2                                                                  |     11  1.6|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  49        |
      Atrophy                              |       1     2  1                                                         |     20  1.8|
      Basophilic Focus                     |                                                                          |      1     |
      Artery, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
      Duct, Metaplasia, Squamous           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Diverticulum                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |          2                                                               |      7  1.3|
      Necrosis                             |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 1  1  2     1  2                                                         |     30  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          | 2        2  2  2                                                         |     23  1.9|
      Hypertrophy                          |       1     2  2                                                         |      7  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +                                                         |  49        |
      Pars Distalis, Hyperplasia           | 2                                                                        |     10  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  | 1     1  1  1  1                                                         |     31  1.4|
      Follicular Cell, Hyperplasia         | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  47        |
      Cyst                                 |                3                                                         |      1  3.0|
      Inflammation, Chronic Active         | 3                                                                        |      4  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  49        |
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +                                                         |  46        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +                                                         |  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
      Hyperostosis                         |                                                                          |      6  3.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
      Cyst                                 |             3                                                            |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Meninges, Hyperplasia                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Epiglottis, Metaplasia, Squamous     | 2  2  2  3  1  4                                                         |     43  2.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          1  1                                                            |      6  1.0|
      Alveolar Epithelium, Metaplasia      | 2  2  3  3  3  3                                                         |     48  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7|                                                        |            |
                             DAY ON TEST   | 3| 1| 3| 8| 3| 3|                                                        |            |
                                           | 3| 9| 4| 1| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  2  2  2  2  2                                                         |     43  1.8|
      Interstitium, Fibrosis               | 2  1  2  2  2  2                                                         |     47  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      3  2.3|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 3  4  3  3  3  3                                                         |     50  2.5|
      Lateral Wall, Hyperplasia            | 3  2  3  3  3  3                                                         |     50  2.6|
      Lateral Wall, Metaplasia, Squamous   | 1  2  1  1  1  1                                                         |     45  1.9|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 4  3  4  4  4  3                                                         |     47  3.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.5|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Nephropathy                          | 2  1  1  2  2  2                                                         |     46  2.1|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                             3            |             
      Necrosis                             |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
      Basophilic Focus                     |       X                                X                    X  X  X  X   |             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Cystic                 |    1                       1              2     2           2        3   |             
      Degeneration, Fatty                  |          2                          3           2                       2|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Inflammation, Granulomatous          |                                                                          |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |    X                                            X                        |             
      Necrosis                             |                                           2                              |             
      Regeneration                         |                                        2                                 |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    1  1              2     2     2     3     2  2  3        1  1     2  1|             
      Centrilobular, Necrosis              |                                        2     2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +  +  +     +                     |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                           3                              |             
      Fat, Necrosis                        |                                              2     2                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                         +                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |    2        1        1  3     3           2        3     2        1  2  1|             
      Basophilic Focus                     |                         X                                                |             
      Hyperplasia                          | 2                                                                        |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                 2              3         |             
      Inflammation, Acute                  |                                     3                                3   |             
      Mineralization                       |                                        2                                 |             
      Necrosis                             | 3                                               4              4        2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                           2        1                     |             
      Necrosis                             |                                                                2        3|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Aorta, Mineralization                |                                           3                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           3        2  2  2  1  2        3  2  2  3     2  3  1  2  1  1|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          | 2           1                 2        2  2  2  2        1           2   |             
      Hypertrophy                          |                                                    2              4  2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          | 1     2  1  1        1     2  1  2        2  3  2                       1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |                                              1  4           3  2     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Metaplasia, Osseous   |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     1  1              1  1     1        1  1  1              1      |             
      Follicular Cell, Hyperplasia         | 1                                                           1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Granuloma Sperm                      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  3                                2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
      Inflammation, Chronic Active         | 3        4                          3  3                       2     3   |             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          4                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |          3  4                             3                 3  2     4   |             
      Artery, Inflammation, Chronic Active |          2                                               1     2     2   |             
      Interstitial Cell, Hyperplasia       | 1           1                    1           1           1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                 +     +     +  +  +                 +     +     +   |             
      Iliac, Hemorrhage                    |                                                                          |             
      Renal, Angiectasis                   |                                     4                                    |             
      Renal, Hemorrhage                    | 2  2                                                     2     2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  M  M        +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  M|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +        +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibrosis                             | 3                          2     2     3     2  2                 3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +        +  +  +  +  M  M  +  +  +  +  +     +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +        M  M  M  +  +  +  +  +  +  M  +     M  +  +  M  +  +|             
      Galactocele                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                             3            |             
      Inflammation, Chronic Active         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Inflammation, Acute         |             3                       3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                           1     2           2        3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                         1        2                                       |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          3  2                                                  1         |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                             2            |             
      Artery, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Artery, Mediastinum, Inflammation    |                                                                          |             
      Artery, Mediastinum, Mineralization  |                                           4                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            2                                             |             
      Thrombosis                           |                      2                       2                           |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                            2                                             |             
      Lateral Wall, Metaplasia, Squamous   |                            2                                             |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1  2  2  2        1  1  1  1  1  2  2  1  1  1  1     1  2  2  2  1  1|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 4| 6| 7| 6| 6| 5| 4| 5| 6| 6| 4| 7| 6| 5| 6| 7| 6| 6| 6| 6| 7| 7| 6|             
                             DAY ON TEST   | 2| 1| 9| 4| 1| 0| 0| 4| 6| 4| 8| 0| 8| 0| 8| 1| 5| 3| 0| 3| 7| 7| 3| 3| 4|             
                                           | 4| 4| 8| 8| 5| 2| 2| 3| 2| 6| 1| 6| 1| 9| 7| 7| 1| 5| 2| 9| 0| 4| 3| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Cornea, Mineralization               |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                        3                                 |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                           2                              |             
      Nephropathy                          | 4  3  2  4  3        3  3  3  3  2  2  2  4  3  4  3     4  4  4  4  4  4|             
      Thrombosis                           |                                                             2            |             
      Artery, Inflammation                 |                                                                          |             
      Papilla, Necrosis                    |                                           2                              |             
      Pelvis, Inflammation, Acute          | 2                                                              2         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |          3                                                               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Inflammation, Acute                  |                                                 2                        |             
      Inflammation, Chronic Active         | 1                                                                        |             
      Transitional Epithelium, Hyperplasia |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                   2                                                      |             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia, Adenomatous             |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Angiectasis                          |       3                                1        2                        |             
      Basophilic Focus                     |             X        X  X        X  X  X                       X         |             
      Clear Cell Focus                     |                                                             X            |             
      Degeneration, Cystic                 |    2     1  2     2              3     3                                 |             
      Degeneration, Fatty                  | 2                 2        3        1           3                        |             
      Eosinophilic Focus                   |                                     X                                    |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                          X|             
      Inflammation, Granulomatous          |                   2                                                      |             
      Mineralization                       |                   2                                                      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                               2                                          |             
      Regeneration                         |    3                                                                     |             
      Thrombosis                           |          2                                                               |             
      Bile Duct, Hyperplasia               |    3  2  2        2  2     2  3  2     1  1                       2      |             
      Centrilobular, Necrosis              |                      1                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                    +     +        +                        |             
      Thrombosis                           |       4                                                                  |             
      Artery, Inflammation, Chronic Active |                                        4                                 |             
      Artery, Mineralization               |       3                                                                  |             
      Fat, Necrosis                        |             2                    3     2        3                        |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Atrophy                              | 3           2     1  2  2     1  2  2                       2            |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                   2                                                      |             
      Artery, Inflammation                 |          2                             4                                 |             
      Artery, Mineralization               |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia, Squamous                |                            2                    3                        |             
      Inflammation, Acute                  |                                                 3                        |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                                2         |             
      Mineralization                       |       3           3                    2                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Developmental Malformation           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +           +                                                      |             
      Aorta, Mineralization                |       2           4                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Cardiomyopathy                       |    2  3  2  2     3  2  3     3  3  3  2  2           2  3  3  2  3     2|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |       2           3                                                      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia                          |             1        1  2  2     2  1  2        2           2           2|             
      Hypertrophy                          |    2                    2           2                                    |             
      Necrosis                             |                   3           3                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia                          |       2              4     2     2        2     2           3           2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperplasia                          |       1           4     3              3        2                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Cyst                                 |                                     3                                    |             
      Pars Distalis, Metaplasia, Osseous   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  | 1  1  1           1     2  1     2     1  1  1  1           1  1  1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Chronic Active         |    2  2                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    4                                                                     |             
      Inflammation, Suppurative            |                   3                                                      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Atrophy                              |                                        3                          1      |             
      Artery, Inflammation, Chronic Active |                         2              3                                2|             
      Interstitial Cell, Hyperplasia       |    1        1              1                          1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +              +           +        +                        |             
      Iliac, Hemorrhage                    |                                        2                                 |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hemorrhage                    |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +     M|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +     +|             
      Hemorrhage                           |                                        2                                 |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Fibrosis                             |                   3                    3  3                       2      |             
      Hematopoietic Cell Proliferation     |                                        1                                 |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M     +  +  +  M  M  +  +  +  +  M  +     M  M  +  M  M     +|             
      Galactocele                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hyperkeratosis                       |       4  3                                                               |             
      Inflammation, Chronic Active         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Inflammation, Acute         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Fibrous Osteodystrophy               |                   3                    2                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Hemorrhage                           |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hemorrhage                           |                                                                   2     2|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hemorrhage                           |                                                                1         |             
      Inflammation, Chronic Active         |                         1              1                                 |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |       2           3                                                      |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  2                       3  2            |             
      Alveolus, Edema                      |                                                          3               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Artery, Mediastinum, Inflammation    |                                        3                                 |             
      Artery, Mediastinum, Mineralization  |       3           3                    2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                        1                                 |             
      Thrombosis                           |          2                 3  1                                          |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  2  1  2  1     2  2  2  2  1  2  2  1  2  1  2     1  1  2  2  2     2|             
      Olfactory Epithelium, Metaplasia     |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Metaplasia, Squamous                 |                   1                                                      |             
      Mineralization                       |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| 5| 6| 3| 6| 5| 5| 5| 6| 6|             
                             DAY ON TEST   | 6| 9| 3| 3| 7| 0| 2| 3| 3| 0| 4| 3| 3| 8| 3| 1| 7| 0| 5| 1| 7| 6| 9| 0| 4|             
                                           | 2| 7| 4| 9| 0| 2| 0| 4| 4| 0| 3| 3| 4| 1| 2| 6| 8| 2| 9| 7| 5| 5| 4| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +                                                            |             
      Cataract                             |          3  3                                                            |             
      Hemorrhage                           |                                                                          |             
      Cornea, Mineralization               |          2                                                               |             
      Retina, Atrophy                      |          4  4                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                      3                                                   |             
      Mineralization                       |       3           4                                                      |             
      Nephropathy                          | 3  4  4  2  3     4  3  4  2  3  4  4  4  3  2  4     2  3  2  3  3     4|             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                        3                                 |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                      3                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |    2                                                                     |      1  2.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia, Adenomatous             |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      4  1.8|
      Basophilic Focus                     | X                                                                        |     14     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |                2                                                         |     13  2.0|
      Degeneration, Fatty                  |                                                                          |      9  2.2|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation, Granulomatous          |    2                                                                     |      2  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      2  2.0|
      Regeneration                         |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  2  2  3     2                                                         |     29  1.9|
      Centrilobular, Necrosis              |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +     +                                                               |  12        |
      Thrombosis                           |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Artery, Mineralization               |    4                                                                     |      3  3.3|
      Fat, Necrosis                        | 2                                                                        |      7  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |       1        3                                                         |     22  1.9|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      2  2.0|
      Artery, Inflammation                 |    4                                                                     |      3  3.3|
      Artery, Mineralization               |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia, Squamous                |                                                                          |      4  2.5|
      Inflammation, Acute                  |                                                                          |      3  3.0|
      Mineralization                       |    4                                                                     |      2  3.0|
      Necrosis                             |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |    3                                                                     |      6  2.3|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   2        |
      Developmental Malformation           |             X                                                            |      2     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   4        |
      Aorta, Mineralization                |    3                                                                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 2  4  1        2                                                         |     39  2.2|
      Mineralization                       |    3                                                                     |      1  3.0|
      Artery, Mineralization               |    3                                                                     |      3  2.7|
      Atrium, Thrombosis                   |          2                                                               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          | 2  1  2  1     2                                                         |     24  1.7|
      Hypertrophy                          |                                                                          |      6  2.3|
      Necrosis                             |                                                                          |      2  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |    3     1     2                                                         |     24  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |     10  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Pars Distalis, Metaplasia, Osseous   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +                                                         |  49        |
      C-Cell, Hyperplasia                  | 1     1  1     2                                                         |     29  1.1|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Chronic Active         |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      7  3.1|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |    3           2                                                         |     10  2.8|
      Artery, Inflammation, Chronic Active |                                                                          |      7  2.0|
      Interstitial Cell, Hyperplasia       |       1                                                                  |     13  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                                                               |  18        |
      Iliac, Hemorrhage                    |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |    2                                                                     |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +                                                         |  43        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  46        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             | 2                                                                        |     12  2.5|
      Hematopoietic Cell Proliferation     |    2                                                                     |      2  1.5|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  M                                                         |  33        |
      Galactocele                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Hyperkeratosis                       |                                                                          |      3  3.3|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Prepuce, Inflammation, Acute         |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |    3                                                                     |      7  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |    2                                                                     |      1  2.0|
      Mineralization                       |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |             1                                                            |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Mineralization                       |    3                                                                     |      3  2.7|
      Thrombosis                           |          3                                                               |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Edema                      |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Artery, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |       2                                                                  |      1  2.0|
      Artery, Mediastinum, Inflammation    |                                                                          |      1  3.0|
      Artery, Mediastinum, Mineralization  |    3                                                                     |      5  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |          2                                                               |      3  1.7|
      Thrombosis                           |       3  3     2                                                         |      8  2.3|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Lateral Wall, Metaplasia, Squamous   |    1                                                                     |      2  1.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  2  2  1  2                                                         |     50  1.5|
      Olfactory Epithelium, Metaplasia     |    1                                                                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |    3                                                                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Cornea, Mineralization               |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |    4                                                                     |      4  3.3|
      Nephropathy                          | 4  4     2  1  3                                                         |     49  3.2|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      2  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 5| 2| 5|                                                        |            |
                             DAY ON TEST   | 9| 7| 0| 3| 4| 8|                                                        |            |
                                           | 5| 6| 1| 7| 7| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 3                                                                        |             
      Parasite Metazoan                    |                X                                               X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1                                                                        |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X           X                    X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 3                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                X     X                 X        X     X        X  X      |             
      Clear Cell Focus                     |                   X                                            X         |             
      Degeneration, Cystic                 | 2                 2                             2  2  1  2        3      |             
      Degeneration, Fatty                  | 2                                                                        |             
      Eosinophilic Focus                   |                         X           X           X                        |             
      Hepatodiaphragmatic Nodule           |                   X     X                    X                           |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             | 2                                                              2         |             
      Bile Duct, Hyperplasia               | 1           2  1  1     2  2  3  1  2  2  2  3  1  3  2  2        2  1  2|             
      Centrilobular, Necrosis              |                   2                       3                             1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +           +                                               +      |             
      Artery, Mineralization               | 3     2                                                                  |             
      Fat, Necrosis                        | 2                 2                                               2      |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2     2     2  2  2     4        3  2     2  3           2     2  2|             
      Hyperplasia                          |                                     2              2                     |             
      Thrombosis                           |                                                       4                  |             
      Artery, Inflammation                 |                                                       3                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                4     3   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       | 4                                               2     1        2         |             
      Necrosis                             |          4                                                     2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       | 4     3                                         3     1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                              3           3               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
      Developmental Malformation           |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +                                         +                        |             
      Aorta, Mineralization                | 4     3                                         3                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     3  2  3  1  2  1  2        2  2  2        3  2  2  1     2  2      |             
      Mineralization                       | 4     2                                                                  |             
      Thrombosis                           |                                        2     1                           |             
      Artery, Mineralization               |                                                 3                        |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                2         |             
      Hyperplasia                          | 2     1     3  1                    2           2     2                  |             
      Hypertrophy                          |                               1                          1        1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2  1  3  2     2  2     3  2  2     1                 2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     2     2  3                                4  2           4  3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 3                                                                        |             
      Pars Distalis, Hyperplasia           |                                           2                              |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     1        2     1     1           2  2  1     1           2  2     2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 +     +                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          3                                               4               |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3                                      2        3  3           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3           3            |             
      Artery, Inflammation, Chronic Active |       2        2                                3                 3      |             
      Interstitial Cell, Hyperplasia       |                1  2  1                    1           1     2     2  1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +        +  +                 +            |             
      Renal, Hemorrhage                    |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     M  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                3  3                    3              2        3  3      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                               3              3              2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     M  +  +  +  +  M  +  M  +  +  +  M  +  M  M  +  M  +  M  +  M  M  +|             
      Galactocele                          |                                                                3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                           4                       3      |             
      Inflammation, Chronic Active         |             4     2              4                 3        3     4      |             
      Prepuce, Inflammation, Acute         |                                                 3     4                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 4     3                                         4              4  1      |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 7| 4| 6| 7| 4| 6| 6| 6| 5| 5| 6| 7| 6| 7| 4| 4| 6| 7| 5| 6|             
                             DAY ON TEST   | 9| 0| 1| 2| 0| 3| 8| 0| 2| 4| 1| 0| 8| 9| 3| 6| 2| 3| 3| 6| 6| 3| 0| 0| 1|             
                                           | 3| 2| 6| 5| 1| 4| 9| 3| 3| 1| 9| 3| 1| 1| 7| 3| 3| 9| 4| 6| 8| 9| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           1                              |             
      Inflammation, Suppurative            |             4                                                            |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 4     2                                         3                        |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                1                                                         |             
      Alveolar Epithelium, Metaplasia      |       1        1  1                             1        1               |             
      Artery, Mediastinum, Mineralization  | 4     2                                         4                        |             
      Interstitium, Fibrosis               |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3     2  1                    1                 1  1                     |             
      Thrombosis                           |             2              2  4        1  3  4                           |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 1        1                                            2                  |             
      Lateral Wall, Hyperplasia            | 3        2                                1           3                  |             
      Lateral Wall, Metaplasia, Squamous   | 3     1  2                                            2                  |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1     1  1  1  2  1  2  2  2  1  2  2  2  2  2  2  2  3  1  1  2  2  1  2|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 3                                                                        |             
      Mineralization                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Degeneration                         |                                                                   3      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
      Hyperplasia, Squamous                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Infarct                              |                            2                                3            |             
      Mineralization                       | 4     2                                         2                        |             
      Nephropathy                          | 4     4  4  4  4  2  2  4  2  3  4  2  2  2  3  4  4  4  3     4  4  3  2|             
      Pelvis, Inflammation, Acute          |                                                                2         |             
      Renal Tubule, Hyperplasia            |                                                       2        2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
      Transitional Epithelium, Hyperplasia |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |             X                                                        X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Necrosis                             |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                      2   |             
      Basophilic Focus                     |          X        X  X  X     X     X  X  X                          X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |          3        1           2        1  3  2     1                     |             
      Degeneration, Fatty                  |    3                          1        1        3                        |             
      Eosinophilic Focus                   |                      X                                                   |             
      Hepatodiaphragmatic Nodule           |                                     X           X                        |             
      Mixed Cell Focus                     |                                                       X                  |             
      Necrosis                             |                                        1                                 |             
      Bile Duct, Hyperplasia               |             2     1  2              1     2  2  2     1     3     2  2   |             
      Centrilobular, Necrosis              |                      1                                      2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +         |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |                   3  2  1     2  2     1     1                 3     2   |             
      Hyperplasia                          |             2           2                                                |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                       2                  |             
      Mineralization                       |                                                                   2      |             
      Necrosis                             |    4     3                    2                                3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                       1                  |             
      Mineralization                       |                   1                                         2     3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |    2                                                           2         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Developmental Malformation           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
      Aorta, Mineralization                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       |    1  2  2  3     2  1  2     2  2  3  2  1        2  1     2     3  3   |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Artery, Mineralization               |                                                                   3      |             
      Atrium, Thrombosis                   |                                              3              3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |          2  1           2     2     2     3  1     2                 1   |             
      Hypertrophy                          |       2  2                             1  2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |    2  1  2  2     3     4     1  2  2  2  3        2        3  1  2  1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +     M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                         2                          3                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                                   4      |             
      Pars Distalis, Hyperplasia           |                                                                2         |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |    1  2  1  1                    1     2     2              2  1  2      |             
      Follicular Cell, Hyperplasia         |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                   3                                               4      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |             3                 3                                          |             
      Artery, Inflammation, Chronic Active |                                        2                             2   |             
      Interstitial Cell, Hyperplasia       |                                     1                       1  2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                                            +           +            |             
      Renal, Hemorrhage                    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  +  +  +     +  +  M     +  +  +  M  +  +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +     +  +  M     +  +  +  +  M  +  +  +  +  +  +  +  +  M   |             
      Hemorrhage                           |                                  2                                       |             
      Infiltration Cellular, Plasma Cell   |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +   |             
      Ectasia                              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +  +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  M  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrosis                             |                                                 3                 4  2   |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  M     +  +  +  +  +  +  M  +  M  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M  +  M     M  +  M     +  +  +  +  M  M  +  +  M  M  +  +  +  +   |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperkeratosis                       |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                3     2   |             
      Prepuce, Inflammation, Acute         |    1                                                  3                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrous Osteodystrophy               |                   1                                2              1      |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Epiglottis, Metaplasia, Squamous     |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 7| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 1| 6| 5| 6| 7| 6|             
                             DAY ON TEST   | 0| 3| 7| 5| 0| 0| 6| 0| 3| 0| 5| 6| 2| 7| 8| 9| 4| 9| 4| 7| 9| 4| 1| 3| 0|             
                                           | 2| 3| 4| 3| 9| 2| 7| 8| 5| 2| 3| 7| 2| 6| 1| 5| 2| 1| 1| 5| 5| 0| 6| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.12 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |          1                                                               |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                   2      |             
      Mineralization                       |                                                                   3      |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1        3                 3                                2         |             
      Alveolar Epithelium, Metaplasia      |                         1                 1                              |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Interstitium, Fibrosis               |                                           1                              |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            |                      2              2              1              3      |             
      Thrombosis                           |                      3                       2  3              2  3      |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                   2                                                      |             
      Lateral Wall, Hyperplasia            |                   2  2                                   2        3      |             
      Lateral Wall, Metaplasia, Squamous   |                                                          2        1      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    2  2  1  2     1  2  1     1  1  2  2  2  2  2  2  2  1  2  1  1  2   |             
      Olfactory Epithelium, Metaplasia     |                      1        1                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                   2                                               4      |             
      Nephropathy                          |    4  2  3  4     4  3  4     4  3  3  4  3  3  3  4  2     3  2  4  4   |             
      Pelvis, Inflammation, Acute          |    2              2                                                      |             
      Renal Tubule, Hyperplasia            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |    2                                                              2      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |       X                                                                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
      Necrosis                             |    3  3                                                                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X     X                                                               |     18     |
      Clear Cell Focus                     |                                                                          |      2     |
      Degeneration, Cystic                 |    2        2                                                            |     16  1.9|
      Degeneration, Fatty                  |                                                                          |      5  2.0|
      Eosinophilic Focus                   |                                                                          |      4     |
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               | 2  1     1  1                                                            |     34  1.8|
      Centrilobular, Necrosis              |          2                                                               |      6  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   6        |
      Artery, Mineralization               |                                                                          |      2  2.5|
      Fat, Necrosis                        |       3                                                                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Atrophy                              |       2                                                                  |     23  2.1|
      Hyperplasia                          |                                                                          |      4  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Squamous                |                                                                          |      2  3.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      5  2.2|
      Necrosis                             |    2                                                                     |      7  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      7  2.4|
      Necrosis                             |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
      Aorta, Mineralization                |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Cardiomyopathy                       |    2     1  2                                                            |     37  2.0|
      Mineralization                       |                                                                          |      2  3.0|
      Thrombosis                           |                                                                          |      2  1.5|
      Artery, Mineralization               |                                                                          |      2  3.0|
      Atrium, Thrombosis                   |       3                                                                  |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Hyperplasia                          |    1  2  1  3                                                            |     20  1.8|
      Hypertrophy                          |                                                                          |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |    2     2                                                               |     29  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  49        |
      Hyperplasia                          |                                                                          |     10  2.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  50        |
      Mineralization                       |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia           |          3                                                               |      3  2.3|
      Pars Intermedia, Hyperplasia         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      C-Cell, Hyperplasia                  | 1     4     1                                                            |     25  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic Active         |                                                                          |      7  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  50        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  50        |
      Atrophy                              |                                                                          |      4  3.0|
      Artery, Inflammation, Chronic Active |    1        2                                                            |      8  2.1|
      Interstitial Cell, Hyperplasia       |    1        1                                                            |     13  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  10        |
      Renal, Hemorrhage                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M                                                            |  38        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  46        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  49        |
      Ectasia                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  47        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Fibrosis                             | 2  3                                                                     |     11  2.8|
      Hematopoietic Cell Proliferation     |          3                                                               |      2  2.0|
      Necrosis                             | 2                                                                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M                                                            |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M                                                            |  29        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       |                                                                          |      3  3.0|
      Inflammation, Chronic Active         |                                                                          |      8  3.1|
      Prepuce, Inflammation, Acute         |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Fibrous Osteodystrophy               |                                                                          |      8  2.5|
      Hyperostosis                         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  50        |
      Epiglottis, Metaplasia, Squamous     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      4  3.0|
      Thrombosis                           |       3                                                                  |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |    3                                                                     |      6  2.2|
      Alveolar Epithelium, Metaplasia      |          1  1                                                            |      9  1.0|
      Artery, Mediastinum, Mineralization  |                                                                          |      3  3.3|
      Interstitium, Fibrosis               |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Inflammation, Suppurative            |                                                                          |     10  1.7|
      Thrombosis                           |       2  3                                                               |     13  2.6|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      4  1.5|
      Lateral Wall, Hyperplasia            |                                                                          |      8  2.3|
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      6  1.8|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  1  1  1                                                            |     50  1.6|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 6|                                                        |            |
                             DAY ON TEST   | 8| 7| 9| 0| 3| 0|                                                        |            |
                                           | 0| 8| 8| 5| 4| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    0.12 PPM                               | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      5  2.8|
      Nephropathy                          | 2  4  3  2  4                                                            |     48  3.2|
      Pelvis, Inflammation, Acute          |                                                                          |      3  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |       X              X                          X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +     +  +  +  A  +  +     +  +  +  +  +  +  +  +     +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  A  +     +  +  +  A  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  A  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X     X                                X                    X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                      2     1  2     2     3     4  1  2     2        2  2|             
      Degeneration, Fatty                  |                                     2                    2     1         |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                         X  X                                X            |             
      Necrosis                             |                                              2                           |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |       2  2     3     2  1  1  1  1  2     2  2  3  2  1     3        3  1|             
      Centrilobular, Necrosis              |                               3     2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                          +     +        +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                      2   |             
      Fat, Necrosis                        |       3                    2                          2     2           3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              | 1     2  3  1  2     2     1  3  3  2        2  2     1        2     1   |             
      Basophilic Focus                     |                                     X                 X                  |             
      Hyperplasia                          |                                                                          |             
      Artery, Inflammation                 |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Diverticulum                         |                X                                                         |             
      Hyperplasia, Squamous                |                                                                      2   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                         3        4                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Mineralization                       |                                                                      4   |             
      Necrosis                             |                                              1                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Aorta, Mineralization                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Cardiomyopathy                       |       1  2  4  2     2  1  2  4  3  2     2  2  2  2  2  2  2  1     3  3|             
      Artery, Mineralization               |                                                                      3   |             
      Atrium, Thrombosis                   |       2                       1              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |             1              2  2              2  2  1  3  2     1     2  2|             
      Hypertrophy                          |                                     2        2                           |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |          2           3  3     3     2           3           2  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                         2                    3                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  M  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                         2           2        2     4                 3  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  I     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Mineralization                       |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                                                              2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      C-Cell, Hyperplasia                  | 1        1                 1     2  1     2  1     1        2        2  1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Granuloma Sperm                      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |       3                 3                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Chronic Active         |                3     3              3                                3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Atrophy                              |                4                 1                                   4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                            2                                            3|             
      Interstitial Cell, Hyperplasia       | 1        1           1  1  2                 1                          2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +     +  +        +           +     +                    +|             
      Renal, Hemorrhage                    |                         2                          3                    2|             
      Renal, Inflammation, Granulomatous   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +  +  +  +     +  +  M  +  +  +     +  +  +  +  +  M  +  +     M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +     M  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Infiltration Cellular, Plasma Cell   |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +     +  +  +  +     +  +  +  M  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hemorrhage                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Fibrosis                             |                         2  2                 1  3           3           2|             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +     +  +  M  +  +  +     +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     +  M  +  M     M  M  M  M  M  +     +  M  +  +  M  M  M  +     +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Hyperkeratosis                       |                                                                         4|             
      Inflammation, Chronic Active         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Fibrous Osteodystrophy               |                                                    2                 3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Epiglottis, Metaplasia, Squamous     | 1     1  1                    2  1                       2               |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Congestion, Chronic                  |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                                                      3   |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 5| 7| 5| 6| 6| 6| 7| 7| 5| 7| 6| 6| 6| 7| 6| 7| 4| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 0| 2| 3| 2| 8| 0| 6| 8| 3| 2| 4| 2| 0| 2| 3| 3| 9| 3| 7| 3| 9| 0| 2| 3|             
                                           | 4| 2| 5| 9| 0| 3| 2| 3| 1| 3| 3| 6| 3| 2| 5| 9| 4| 5| 3| 0| 5| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      | 2     1  2  2  3     2  3  1  1  3  2     2  3  2  3  1  2  2  2     2  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1                    1  2  1     1  1        1     1  1  2  1  1        1|             
      Artery, Mediastinum, Mineralization  |                                                                      3   |             
      Interstitium, Fibrosis               | 1     1     1  2     1  2  1        2     1  2  1  2  1  2  1  1     1  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Suppurative            |       1  1     1                 1                    2  1           3  1|             
      Thrombosis                           |       3  2           2                    2  3                       2   |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2     1  1  3  2     1     2  2  2  2        1  2  2  2  3  2  1        2|             
      Lateral Wall, Hyperplasia            | 1     3  2  2  1     3  2  3  2  2  2     3  2  2  2  3  3  2  1     2  2|             
      Lateral Wall, Metaplasia, Squamous   |       4  2  2        2  1  2  2  2  1     3  2     1     2  1        3  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2     2  2  1  1     1  1  2  1  1  1     1  1  2  1  1  1  2  1     1  2|             
      Olfactory Epithelium, Metaplasia     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                             +               |             
      Cataract                             |                            3                             2               |             
      Cornea, Inflammation, Chronic Active |                            2                                             |             
      Retina, Atrophy                      |                            3                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Angiectasis                          |                                                                      3   |             
      Cyst                                 |                                                    3                     |             
      Mineralization                       |                                                                      3   |             
      Nephropathy                          | 3     2  2  4  2     3  4  4  3  3  4     2  4  4  4  4  4  4  2     4  4|             
      Thrombosis                           |                                                                         2|             
      Artery, Inflammation                 |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                      1   |             
      Renal Tubule, Hyperplasia            |                                                                         2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Chronic Active         |                         2           2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                X     X        X                    X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                       X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4                                2                        |             
      Basophilic Focus                     |    X           X           X                       X                    X|             
      Clear Cell Focus                     |                                                                X         |             
      Degeneration, Cystic                 |             2                       2           3  1  3                  |             
      Degeneration, Fatty                  |                                  1  2                                    |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hepatodiaphragmatic Nodule           |                                     X     X                              |             
      Mixed Cell Focus                     |                                              X                           |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                 3                        |             
      Bile Duct, Hyperplasia               | 3     3     1           1  2  2  2  1  3  2  2  3     2     1     3  3  2|             
      Centrilobular, Necrosis              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +                                         +              +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |       2        2                                                        2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4           3           2  1        2  2  1  1        3     1  2  2  2  1|             
      Basophilic Focus                     |    X                                                                     |             
      Hyperplasia                          |                            2                 4                          1|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                         X|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |                                                          2               |             
      Mineralization                       |                                                                   2      |             
      Necrosis                             |             2  2  2     4           1              4        3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2        3  1                 1           1                    3      |             
      Necrosis                             |                2                                   4                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     2  1        2  2     2  2  1  1  1  1     1  3  1     2  2  2|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                     4  2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2     1  2        1  1        2     2  3  1     2  2               |             
      Hypertrophy                          | 2  2                    2              2                 2               |             
      Necrosis                             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  2  2     2  2  2     3           4  2  2        2  3  2  1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1        2  3        2  3                                      3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Pars Distalis, Hyperplasia           |                               1                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1     1  1  1     1  1  1  1  2           1  1  1  1     1  1  3  1|             
      Follicular Cell, Hyperplasia         |                                              1        1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                              3                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4                 2        3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                         3                                                |             
      Interstitial Cell, Hyperplasia       |    1  1           2              2                                   1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +        +  +     +  +     +     +  +  +  +        +  +     +      |             
      Renal, Hemorrhage                    |                2        2                                         2      |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +     +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 2     2        2                 3        2     3        3           3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                   3                                                      |             
      Necrosis                             |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  M  +  +  +  M  M  M  M  +  +  +  +  +  M  M  +  M  M|             
      Galactocele                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |             1  1        2                                         2      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +        +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |       2     1  1                             1  1     1     1        1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Chronic                  |                                     3                                    |             
      Metaplasia, Osseous                  |                                                                      1   |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                            1                          2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 6| 6| 6| 4| 2| 6| 7| 5| 4| 6| 6| 5| 7| 7| 6| 6| 6| 4| 3| 6| 5| 4|             
                             DAY ON TEST   | 7| 8| 0| 0| 1| 6| 5| 6| 8| 3| 2| 9| 8| 0| 2| 0| 1| 2| 9| 2| 9| 8| 5| 7| 4|             
                                           | 8| 3| 4| 2| 1| 9| 4| 4| 1| 5| 7| 8| 7| 8| 0| 1| 5| 1| 8| 5| 9| 7| 4| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Metaplasia      | 2  2        2  2  2  1  2  2     2  2  2  2  1     2  1  2  2  2  2  2  1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1        2  1        1  1     1     1  1           1  2        2      |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Interstitium, Fibrosis               | 1  1        2  1  2     2  1     2  1  2  2  1     1     2  1  1  2  2  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            4  2     1                                    |             
      Thrombosis                           | 1     1                       1        1                    2        3   |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 1  2  1     1  1     1  1  1  1     2  1  2  1        2  1     1  1  1  1|             
      Lateral Wall, Hyperplasia            | 2  2  2     1  1  1  2  1  2  3  2  2  2  3  1  2  2  3  2  3  1  2  2  1|             
      Lateral Wall, Metaplasia, Squamous   | 2  1  2           1        2  2  1  2  1  2     1  1  2  1  2     2  2   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  2     2  1  1  1  1  1  2  2  2  3  2  1  2  1  2  2  3  2  1  2  3|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 2                                                                        |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  3  2     4  4  2  1  4  4  2  2  3  2  3  3  4  4  4  4  2  2  4  2  2|             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                  2                                       |             
      Pelvis, Inflammation, Acute          |             3                                   2                        |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    | X                                                                        |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      2  3.0|
      Basophilic Focus                     |       X                                                                  |     11     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |    3  1  1                                                               |     19  2.1|
      Degeneration, Fatty                  |                                                                          |      5  1.6|
      Eosinophilic Focus                   |       X                                                                  |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Mixed Cell Focus                     |                                                                          |      4     |
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |    2  3  2                                                               |     37  2.0|
      Centrilobular, Necrosis              |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                                                               |  12        |
      Artery, Inflammation, Chronic Active |    3                                                                     |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Fat, Necrosis                        |          3                                                               |      9  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Atrophy                              |    2                                                                     |     30  1.9|
      Basophilic Focus                     |       X                                                                  |      4     |
      Hyperplasia                          |    2                                                                     |      4  2.3|
      Artery, Inflammation                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Diverticulum                         |                                                                          |      2     |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      9  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Mineralization                       |                                                                          |      7  2.1|
      Necrosis                             |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Cardiomyopathy                       | 2  3  2  3  2                                                            |     44  2.0|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |     23  1.8|
      Hypertrophy                          |                                                                          |      7  2.0|
      Necrosis                             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |    2     3                                                               |     24  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  48        |
      Hyperplasia                          |    2     3                                                               |     15  2.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  49        |
      Mineralization                       |    2                                                                     |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      C-Cell, Hyperplasia                  | 2                                                                        |     31  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |  50        |
      Granuloma Sperm                      |          2                                                               |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |  50        |
      Cyst                                 |    4                                                                     |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    4                                                                     |      5  3.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |  50        |
      Atrophy                              |                                                                          |      6  3.0|
      Artery, Inflammation, Chronic Active |          3                                                               |      4  2.8|
      Interstitial Cell, Hyperplasia       |       1                                                                  |     13  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |  24        |
      Renal, Hemorrhage                    |                                                                          |      6  2.2|
      Renal, Inflammation, Granulomatous   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +                                                            |  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  46        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +                                                            |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Fibrosis                             | 3  2                                                                     |     16  2.4|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +                                                            |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M                                                            |  28        |
      Galactocele                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Fibrous Osteodystrophy               |    3     2                                                               |      8  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +                                                            |  50        |
      Epiglottis, Metaplasia, Squamous     |    1     2                                                               |     16  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Congestion, Chronic                  |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.7|
      Alveolar Epithelium, Metaplasia      | 2  2  2  2                                                               |     46  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2     1                                                               |     27  1.2|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  3.0|
      Interstitium, Fibrosis               | 1  1     1                                                               |     40  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Inflammation, Suppurative            |    3                                                                     |     12  1.8|
      Thrombosis                           |                                                                          |     12  1.9|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |    1  2  1  2                                                            |     41  1.5|
      Lateral Wall, Hyperplasia            | 2  2  2  2  1                                                            |     50  2.0|
      Lateral Wall, Metaplasia, Squamous   | 2  2     1                                                               |     36  1.8|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  1  2  2  1                                                            |     50  1.6|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
      Inflammation, Acute                  |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  2.5|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 4| 6|                                                        |            |
                             DAY ON TEST   | 7| 9| 3| 4| 3| 0|                                                        |            |
                                           | 1| 7| 4| 9| 3| 2|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |    3                                                                     |      3  2.7|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 2  4  3  4  4                                                            |     50  3.2|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |    3                                                                     |      4  2.3|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic Active         |    2                                                                     |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X           X                 X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       X           X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1  2                 1               |             
      Basophilic Focus                     |       X     X                    X  X        X           X  X  X         |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 1                                2              2  2              1     2|             
      Degeneration, Fatty                  |             1                             2                              |             
      Eosinophilic Focus                   |                                     X                                    |             
      Hepatodiaphragmatic Nodule           |             X                       X                                    |             
      Mixed Cell Focus                     |                                                 X                        |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |       1  2        1  3  3  2  1     2  2           3  2              2  2|             
      Centrilobular, Necrosis              |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +  +  +              +  +                    +|             
      Artery, Mineralization               |                                                 3                        |             
      Fat, Necrosis                        |                      2     3  2  2                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3  2              3  1  2     3  2        3  3  3  2  2            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                X                                                         |             
      Hyperplasia, Squamous                |                                           3                    3         |             
      Inflammation, Acute                  |                   3                                            3         |             
      Mineralization                       |                                                 3                        |             
      Necrosis                             |             3     4                       2  2                    3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                   3                                                      |             
      Mineralization                       |       1                                         3                 1      |             
      Necrosis                             |                                                    1                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Inflammation, Chronic Active         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
      Aorta, Mineralization                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2     2  2  2  1        3  1  3     2  1  3  2  1     1  2  2     1|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     2  1  2     2           2        2  2  2  1              2        1|             
      Hypertrophy                          |       2        2        2                             2                  |             
      Necrosis                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3     2     3     2  1  2  2     1              2  3     2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2  2                    2     4        3     2  3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hemorrhage            |                                                                      4   |             
      Pars Distalis, Hyperplasia           |                               3     4                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1           2           1  1  1                 1        2  1     1      |             
      Follicular Cell, Hyperplasia         |             3           1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 4        3     2         |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Chronic Active         |                                                                4     2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2  3  4           3     3|             
      Artery, Inflammation, Chronic Active |       2                                                        2         |             
      Interstitial Cell, Hyperplasia       |       2                    1     1     1  1     2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M     +  M  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Plasma Cell   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             2        2  2           2           2  2  2           1      |             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  M  +  +  +  +  +  M  M  M  +  M  +  +  +  +  M  +  +  +  M  M  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                 4                 1      |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                 2                        |             
      Epiglottis, Metaplasia, Squamous     | 3        2  4  3  1  3  3  1  2  1     1  1  3  4  2  2  4  2  4  1     2|             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
      Mineralization                       |                                                 3                        |             
      Alveolar Epithelium, Hyperplasia     | 2                    2                       3                           |             
      Alveolar Epithelium, Metaplasia      | 3     3  2  3  4  3  3  3  3  3  3  3  2  3  4  3  2  2  3  2  3  4  3  3|             
      Alveolus, Edema                      |                                                                      1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2     2     2  2  2  2  2  2  2  2  2  2  2  3  2        2  2  2  3  1  2|             
      Artery, Mediastinum, Mineralization  |                                                 3                        |             
      Bronchiole, Necrosis                 |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 5| 6| 7| 7| 6| 7| 5| 7| 6| 7| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 4| 5|             
                             DAY ON TEST   | 1| 0| 3| 4| 5| 2| 3| 8| 1| 6| 3| 4| 3| 7| 0| 6| 5| 8| 1| 5| 1| 5| 5| 5| 8|             
                                           | 6| 2| 5| 0| 8| 3| 4| 1| 5| 2| 5| 0| 5| 4| 0| 7| 3| 3| 6| 1| 1| 9| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Fibrosis               | 2     2     2  3  2  2  3  2  2  2  2  2  3  3  2     2  3  1  3  3  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1  3     2  2                    3  3     1  2        2      |             
      Thrombosis                           |          1                                         3  2                 2|             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2     3  3  2     2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  3  2|             
      Lateral Wall, Hyperplasia            | 2     3  2  3  2  3  3  3  2  3  3  2  2  3  3  3  2  3  3  2  3  3  2  3|             
      Lateral Wall, Metaplasia, Squamous   | 3     1  2  3  4     4  1  1  1  2     2  2  4  3  2  2  3  1  2  3  1  1|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2     3  2  2  2  3  2  2  3  3  3  4  2  2  1  2  2  2  2  3  3  3  3  2|             
      Olfactory Epithelium, Metaplasia     |                      4                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2                                                        3      |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                 2                        |             
      Nephropathy                          | 3     4  2  4  4  4  4  3  2  4  3  4  3  4  4  4  2  4  4  3  4  4  2  2|             
      Pelvis, Inflammation, Acute          |                                           2              2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |                         X                             X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Parasite Metazoan                    |                X        X                                X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Necrosis                             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Angiectasis                          |                                     2                                    |             
      Basophilic Focus                     |                                                          X               |             
      Clear Cell Focus                     |                      X                                                   |             
      Degeneration, Cystic                 | 2              1     2        3              1  2                        |             
      Degeneration, Fatty                  |                                                 2                        |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hepatodiaphragmatic Nodule           |                                                 X        X               |             
      Mixed Cell Focus                     |                                                                          |             
      Regeneration                         | 2                                      2                                 |             
      Bile Duct, Hyperplasia               | 3  2  3        2     1  2  1        2  3  2  2  2  2     2     1     2   |             
      Centrilobular, Necrosis              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                               4                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Atrophy                              | 2  1           1           3        1  2     2  2  3           2     1   |             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Foreign Body                         |                                                                          |             
      Hyperplasia, Squamous                |                               3                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                    2     2               |             
      Necrosis                             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Cyst                                 |                               3                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                      2                 1           2     1     2         |             
      Necrosis                             |       2                                                        3         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Cardiomyopathy                       |    2        1  2     2  2     2     2        2  2  2  2  2     2  1  2   |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia                          |                                           2        2     1           2   |             
      Hypertrophy                          |                               2                    4     1               |             
      Necrosis                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia                          | 2                                            2           1     1     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  +     +  +  M  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia                          |                      3                                   1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +     +  +  I  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                   1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      C-Cell, Hyperplasia                  |                1                    3              1     1               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +  +     +  +  +  +     +  +  M  +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                               3                          2           2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             2        4  3           3                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1                          2                                         1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +        +  +              +     +                    +   |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  M  +  +     +  +  +   |             
      Fibrosis                             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     M  +     +  +  +  M     +  +  M  +  +  +  +  +     +  +  +   |             
      Infiltration Cellular, Plasma Cell   |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  M     +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Fibrosis                             | 2  2                 2              3                                3   |             
      Hyperplasia, Focal                   |                               3                                          |             
      Necrosis                             |                                           4                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M     M  +     +  M  +  +     +  +  +  +  +  M  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     +  M     +  +  +  M     +  M  +  +  M  M  +  +     +  M  M   |             
      Galactocele                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Fibrous Osteodystrophy               |                      3                                                   |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Mineralization                       |                                                                          |             
      Epiglottis, Metaplasia, Squamous     | 2  2        3  1     3  3  1        3  2  4  3        3  1     3  1  2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolar Epithelium, Metaplasia      | 3     3     3  3     3  3  2  2     3  3  3  3  3  3     3     3  3  3   |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  1  2     2  2     2  2     2     2     2  2  2  2     2     2  2  1   |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Bronchiole, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 5| 5| 6| 6| 6| 5| 7| 6| 6| 6| 6| 6| 6| 7| 4| 7| 6| 5| 3| 6| 6|             
                             DAY ON TEST   | 5| 1| 2| 0| 6| 0| 0| 9| 3| 2| 0| 0| 2| 5| 6| 6| 2| 3| 2| 3| 0| 9| 7| 1| 0|             
                                           | 2| 9| 1| 2| 8| 2| 2| 5| 5| 6| 9| 2| 3| 4| 7| 7| 3| 5| 2| 4| 2| 6| 2| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Fibrosis               | 2     2     2  3     3  2  2  1        3  2  2  2  2     2     2  2  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Suppurative            |       1              2              1  1  2  2           1     3         |             
      Thrombosis                           |       4                                2     3                           |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2  2     2  3     2  3  3  1     2  1  2  1  2     3  3     3  2  2   |             
      Lateral Wall, Hyperplasia            | 3  2  2     3  3     3  3  2  3     3  3  3  2  3     3  3     3  2  3   |             
      Lateral Wall, Metaplasia, Squamous   | 1  1  3     1  1     4  3  2  1     3  4  3  2  2     2  2     3  2  2   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 4  4  3     2  3     3  3  2  1     3  2  4  2  3  1  1  3     1  2  1   |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                        3                                 |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  3  2     3  2     4  4  2  3     3  2  3  3  3  4  3  3     3  2  2   |             
      Pelvis, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                      1                                                   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |    X                                                                     |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      4  1.5|
      Basophilic Focus                     |                                                                          |      9     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 | 3  3                                                                     |     14  1.9|
      Degeneration, Fatty                  | 2                                                                        |      4  1.8|
      Eosinophilic Focus                   |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Regeneration                         |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |    2  1     1  2                                                         |     33  1.9|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Artery, Mineralization               |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              | 2           3  2                                                         |     26  2.2|
      Hyperplasia                          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Foreign Body                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      3  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Mineralization                       |    1                                                                     |      4  2.0|
      Necrosis                             | 3                                                                        |      7  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       | 4  1                                                                     |     10  1.8|
      Necrosis                             |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   2        |
      Aorta, Mineralization                | 4                                                                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 3     2  1                                                               |     36  1.8|
      Artery, Mineralization               | 4                                                                        |      1  4.0|
      Atrium, Thrombosis                   | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          | 2  2                                                                     |     18  1.7|
      Hypertrophy                          |                                                                          |      7  2.1|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |       2                                                                  |     17  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  47        |
      Hyperplasia                          | 4  1                                                                     |     11  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  49        |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       2     3                                                            |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  | 2  2     2                                                               |     16  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Granuloma Sperm                      |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Chronic Active         |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      6  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              | 4                                                                        |      6  3.2|
      Artery, Inflammation, Chronic Active | 3                                                                        |      3  2.3|
      Interstitial Cell, Hyperplasia       |                                                                          |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +                                                            |  10        |
      Renal, Hemorrhage                    |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M                                                         |  38        |
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +                                                         |  42        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |    2                                                                     |     14  2.1|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M                                                         |  30        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               | 4                                                                        |      4  3.0|
      Hyperostosis                         |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Necrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Epiglottis, Metaplasia, Squamous     | 4  2  2  1  1  2                                                         |     43  2.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       | 4                                                                        |      2  3.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.3|
      Alveolar Epithelium, Metaplasia      | 3  3  2  3  3                                                            |     47  2.9|
      Alveolus, Edema                      |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2  1  2  1                                                            |     42  1.9|
      Artery, Mediastinum, Mineralization  | 3                                                                        |      2  3.0|
      Bronchiole, Necrosis                 |                                                                          |      1  1.0|
      Interstitium, Fibrosis               | 2  2  2  2  2                                                            |     44  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            | 2     3  1                                                               |     20  1.9|
      Thrombosis                           |                4                                                         |      8  2.6|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 1  1  2  3  3  2                                                         |     48  2.1|
      Lateral Wall, Hyperplasia            | 3  3  3  3  3  3                                                         |     49  2.7|
      Lateral Wall, Metaplasia, Squamous   | 4  3  3  2     2                                                         |     46  2.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  3  1  4  1  3                                                         |     50  2.4|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
      Metaplasia, Squamous                 | 2                                                                        |      1  2.0|
      Mineralization                       | 2                                                                        |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 | 2                                                                        |      3  2.3|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       | 3                                                                        |      2  2.5|
      Nephropathy                          | 4  4  3  3  2  2                                                         |     50  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 88034-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:31:33  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 5| 6|                                                        |            |
                             DAY ON TEST   | 2| 3| 4| 9| 5| 6|                                                        |            |
                                           | 3| 3| 4| 0| 9| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Inflammation, Acute          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
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