TDMS Study 88034-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) OZONE NTP Experiment-Test: 88034-06 Report: PEIRPT03 Study Type: CHRONIC 30-MONTH Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 03/09/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund Sacrifice 34 25 33 Natural Death 7 13 7 Survivors Terminal Sacrifice 9 12 10 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (43) (38) (44) Inflammation, Suppurative 1 (2%) Epithelium, Hyperplasia 2 (5%) Intestine Small, Duodenum (45) (41) (46) Necrosis 1 (2%) 1 (2%) Epithelium, Hyperplasia 1 (2%) Peyer's Patch, Hyperplasia 1 (2%) Liver (49) (50) (50) Angiectasis 1 (2%) 1 (2%) Basophilic Focus 1 (2%) 3 (6%) Clear Cell Focus 1 (2%) Degeneration, Fatty 1 (2%) Eosinophilic Focus 3 (6%) 6 (12%) 3 (6%) Hematopoietic Cell Proliferation 4 (8%) 4 (8%) Inflammation, Chronic 2 (4%) 4 (8%) 1 (2%) Necrosis 7 (14%) 3 (6%) 3 (6%) Pigmentation 2 (4%) 2 (4%) 1 (2%) Vacuolization Cytoplasmic, Focal 1 (2%) Bile Duct, Cyst 1 (2%) 2 (4%) Bile Duct, Hyperplasia 1 (2%) 1 (2%) Centrilobular, Degeneration 1 (2%) Centrilobular, Necrosis 1 (2%) 1 (2%) Hepatocyte, Atrophy 1 (2%) Mesentery (13) (5) (10) Artery, Inflammation 1 (8%) Fat, Inflammation, Chronic 1 (8%) Fat, Necrosis 9 (69%) 2 (40%) 4 (40%) Lymphatic, Angiectasis 1 (10%) Pancreas (48) (48) (49) Atrophy 5 (10%) 1 (2%) 3 (6%) Basophilic Focus 5 (10%) Inflammation 2 (4%) 1 (2%) Duct, Cyst 2 (4%) 1 (2%) 2 (4%) Stomach, Forestomach (48) (50) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation, Suppurative 2 (4%) 3 (6%) 3 (6%) Necrosis 1 (2%) 1 (2%) 1 (2%) Epithelium, Hyperplasia 3 (6%) 2 (4%) 6 (12%) Stomach, Glandular (48) (49) (48) Inflammation, Acute 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) 1 (2%) Epithelium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) Cardiomyopathy 37 (74%) 38 (76%) 36 (72%) Inflammation, Suppurative 1 (2%) Necrosis 1 (2%) Pigmentation, Hemosiderin 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (48) (49) (50) Angiectasis 1 (2%) Hyperplasia 3 (6%) 2 (4%) 3 (6%) Hypertrophy 6 (13%) 5 (10%) 6 (12%) Capsule, Hyperplasia 1 (2%) 2 (4%) Adrenal Medulla (48) (49) (50) Hyperplasia 4 (8%) 3 (6%) 4 (8%) Islets, Pancreatic (47) (47) (48) Hyperplasia 1 (2%) Parathyroid Gland (36) (28) (29) Hyperplasia 1 (3%) Pituitary Gland (48) (48) (49) Pars Distalis, Hyperplasia 11 (23%) 14 (29%) 16 (33%) Pars Intermedia, Hyperplasia 1 (2%) 2 (4%) 1 (2%) Pars Intermedia, Hypertrophy 1 (2%) Thyroid Gland (49) (49) (50) Follicular Cell, Hyperplasia 22 (45%) 24 (49%) 30 (60%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (45) (44) (42) Inflammation, Chronic Active 1 (2%) 2 (5%) Ovary (49) (48) (50) Angiectasis 3 (6%) 2 (4%) 1 (2%) Atrophy 28 (57%) 33 (69%) 30 (60%) Cyst 23 (47%) 18 (38%) 16 (32%) Inflammation, Chronic 1 (2%) 1 (2%) Necrosis 1 (2%) Germinal Epithelium, Hyperplasia 2 (4%) 4 (8%) Interstitial Cell, Hyperplasia 2 (4%) Uterus (49) (50) (50) Angiectasis 4 (8%) 3 (6%) 2 (4%) Cyst 6 (12%) 2 (4%) 9 (18%) Decidual Reaction 1 (2%) Hemorrhage 1 (2%) Hydrometra 3 (6%) 5 (10%) 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) Thrombosis 2 (4%) Endometrium, Hyperplasia 1 (2%) 2 (4%) Myometrium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (49) (50) Angiectasis 2 (4%) Hyperplasia 3 (6%) 1 (2%) 4 (8%) Lymph Node (15) (6) (9) Hyperplasia 1 (7%) Iliac, Angiectasis 2 (13%) Iliac, Hyperplasia 1 (7%) Lumbar, Congestion 1 (7%) Lumbar, Hyperplasia 1 (11%) Renal, Congestion 1 (7%) Renal, Hyperplasia 1 (11%) Lymph Node, Bronchial (36) (32) (33) Hyperplasia 1 (3%) 1 (3%) 1 (3%) Infiltration Cellular, Plasma Cell 1 (3%) Infiltration Cellular, Histiocyte 1 (3%) Lymph Node, Mandibular (38) (40) (41) Hematopoietic Cell Proliferation 1 (3%) Hyperplasia 2 (5%) 4 (10%) 3 (7%) Necrosis 1 (3%) Lymph Node, Mesenteric (45) (48) (44) Angiectasis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Congestion 2 (4%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) Lymph Node, Mediastinal (43) (36) (38) Hyperplasia 5 (12%) 9 (25%) 1 (3%) Infiltration Cellular, Histiocyte 2 (5%) Spleen (49) (50) (50) Hematopoietic Cell Proliferation 15 (31%) 19 (38%) 21 (42%) Hyperplasia, Histiocytic 1 (2%) Hyperplasia, Lymphoid 6 (12%) 9 (18%) 4 (8%) Infiltration Cellular, Histiocyte 1 (2%) Thymus (35) (35) (33) Atrophy 2 (6%) 3 (9%) 1 (3%) Hyperplasia, Lymphoid 1 (3%) 2 (6%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) 3 (6%) Skin (50) (50) (50) Inflammation, Chronic Active 1 (2%) Inflammation, Suppurative 1 (2%) Vulva, Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) Chondradysplasia 1 (2%) Fibrous Osteodystrophy 15 (30%) 18 (36%) 14 (28%) Fracture 1 (2%) Cranium, Fracture 1 (2%) Cranium, Myelofibrosis 1 (2%) Femur, Myelofibrosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (49) (50) Angiectasis 1 (2%) Hydrocephalus 1 (2%) Meninges, Infiltration Cellular 2 (4%) 2 (4%) 2 (4%) Peripheral Nerve (1) Degeneration 1 (100%) Spinal Cord (1) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - CONT Degeneration 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (50) Hyperplasia 13 (26%) 11 (22%) 24 (48%) Inflammation, Chronic Active 4 (8%) Inflammation, Suppurative 5 (10%) 4 (8%) 10 (20%) Necrosis 2 (4%) Epiglottis, Hyperplasia 4 (8%) Epiglottis, Metaplasia, Squamous 2 (4%) 2 (4%) 19 (38%) Lung (50) (49) (50) Congestion, Chronic 2 (4%) Hemorrhage 1 (2%) 2 (4%) 1 (2%) Inflammation, Chronic, Focal 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%) Alveolar Epithelium, Metaplasia 43 (88%) 50 (100%) Alveolus, Infiltration Cellular, Histiocyte 5 (10%) 39 (80%) 45 (90%) Mediastinum, Angiectasis 1 (2%) Mediastinum, Necrosis 1 (2%) Perivascular, Infiltration Cellular 6 (12%) 1 (2%) Nose (50) (49) (50) Artery, Inflammation 1 (2%) Lateral Wall, Degeneration, Hyaline 49 (100%) 50 (100%) Lateral Wall, Fibrosis 1 (2%) 23 (47%) 48 (96%) Lateral Wall, Hyperplasia 1 (2%) 42 (86%) 47 (94%) Lateral Wall, Inflammation, Suppurative 3 (6%) 44 (90%) 50 (100%) Lateral Wall, Metaplasia, Squamous 2 (4%) 3 (6%) 28 (56%) Lateral Wall, Necrosis 1 (2%) Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%) Olfactory Epithelium, Atrophy 9 (18%) 23 (47%) 40 (80%) Turbinate, Hyperplasia 1 (2%) Turbinate, Inflammation, Suppurative 1 (2%) Trachea (48) (48) (50) Metaplasia, Squamous 1 (2%) Mineralization 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (1) Inflammation, Granulomatous 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (49) (50) Fibrosis, Focal 1 (2%) Glomerulosclerosis 2 (4%) Hydronephrosis 1 (2%) 2 (4%) Infarct 1 (2%) Karyomegaly 2 (4%) Metaplasia, Osseous 4 (8%) 1 (2%) 5 (10%) Mineralization 1 (2%) Nephropathy 24 (49%) 27 (55%) 30 (60%) Cortex, Inflammation, Suppurative 1 (2%) Pelvis, Dilatation 1 (2%) Renal Tubule, Hyperplasia 2 (4%) Urinary Bladder (47) (48) (46) Inflammation, Suppurative 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 10 9 15 Moribund Sacrifice 26 30 23 Survivors Terminal Sacrifice 14 11 12 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (43) (44) (40) Inflammation, Suppurative 1 (2%) 2 (5%) Mineralization 1 (3%) Epithelium, Hyperplasia 1 (2%) Intestine Small, Duodenum (44) (45) (38) Necrosis 1 (2%) Intestine Small, Jejunum (43) (44) (41) Peyer's Patch, Hyperplasia 2 (5%) Liver (49) (50) (50) Angiectasis 1 (2%) Basophilic Focus 2 (4%) 1 (2%) 2 (4%) Clear Cell Focus 1 (2%) Degeneration, Fatty 2 (4%) 1 (2%) 2 (4%) Eosinophilic Focus 10 (20%) 9 (18%) 3 (6%) Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%) Necrosis 3 (6%) 8 (16%) 3 (6%) Bile Duct, Cyst 1 (2%) 1 (2%) 2 (4%) Centrilobular, Necrosis 1 (2%) 1 (2%) Mesentery (3) (3) (4) Artery, Inflammation, Chronic Active 1 (25%) Fat, Necrosis 1 (33%) 1 (33%) 2 (50%) Pancreas (49) (49) (49) Atrophy 3 (6%) 3 (6%) 1 (2%) Basophilic Focus 1 (2%) Cytoplasmic Alteration 1 (2%) Vacuolization Cytoplasmic 1 (2%) Duct, Cyst 1 (2%) Stomach, Forestomach (49) (49) (50) Angiectasis 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Suppurative 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Necrosis 3 (6%) Epithelium, Hyperplasia 1 (2%) 4 (8%) 3 (6%) Stomach, Glandular (49) (47) (48) Inflammation, Acute 1 (2%) 1 (2%) Mineralization 1 (2%) Necrosis 2 (4%) 3 (6%) 1 (2%) Epithelium, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Mineralization 1 (100%) Heart (50) (50) (50) Cardiomyopathy 40 (80%) 40 (80%) 40 (80%) Inflammation, Suppurative 2 (4%) Mineralization 1 (2%) Necrosis 1 (2%) 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) Atrium, Thrombosis 2 (4%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (47) (49) (49) Hyperplasia 9 (19%) 13 (27%) 8 (16%) Hypertrophy 20 (43%) 16 (33%) 13 (27%) Capsule, Hyperplasia 9 (19%) 12 (24%) 7 (14%) Adrenal Medulla (48) (48) (49) Hyperplasia 2 (4%) 2 (4%) Thrombosis 1 (2%) Islets, Pancreatic (49) (49) (49) Hyperplasia 4 (8%) 1 (2%) 2 (4%) Pituitary Gland (47) (49) (48) Pars Distalis, Hyperplasia 1 (2%) 4 (8%) 3 (6%) Pars Intermedia, Hyperplasia 1 (2%) 2 (4%) Thyroid Gland (49) (48) (50) Follicular Cell, Hyperplasia 18 (37%) 20 (42%) 32 (64%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (49) (49) (50) Atrophy 1 (2%) Granuloma Sperm 1 (2%) 1 (2%) Inflammation 2 (4%) 1 (2%) Inflammation, Chronic 1 (2%) Penis (4) (2) (7) Inflammation, Suppurative 3 (75%) 2 (100%) 5 (71%) Preputial Gland (49) (49) (49) Cyst 11 (22%) 11 (22%) 8 (16%) Hyperplasia 1 (2%) Inflammation, Chronic Active 15 (31%) 13 (27%) 9 (18%) Prostate (48) (47) (47) Hyperplasia 1 (2%) Inflammation, Suppurative 3 (6%) 5 (11%) 3 (6%) Artery, Inflammation, Chronic Active 1 (2%) Seminal Vesicle (48) (49) (49) Hyperplasia 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Testes (50) (49) (50) Atrophy 11 (22%) 10 (20%) 5 (10%) Mineralization 1 (2%) 1 (2%) Interstitial Cell, Hyperplasia 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (49) (50) Hyperplasia 3 (6%) 5 (10%) 4 (8%) Hyperplasia, Megakaryocyte 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Necrosis 1 (2%) Lymph Node (2) (3) (7) Congestion 1 (14%) Iliac, Hyperplasia 2 (29%) Iliac, Infiltration Cellular, Plasma Cell 1 (50%) Iliac, Pigmentation 1 (33%) Renal, Hyperplasia 2 (29%) Lymph Node, Bronchial (26) (27) (32) Hyperplasia 1 (4%) 2 (6%) Lymph Node, Mandibular (34) (31) (32) Hyperplasia 1 (3%) 1 (3%) Infiltration Cellular, Mast Cell 1 (3%) Lymph Node, Mesenteric (48) (46) (44) Angiectasis 3 (6%) 4 (9%) Congestion 1 (2%) 2 (4%) Hematopoietic Cell Proliferation 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hemorrhage 1 (2%) Hyperplasia 2 (4%) 2 (4%) 3 (7%) Lymph Node, Mediastinal (37) (39) (43) Hyperplasia 1 (3%) 5 (13%) 5 (12%) Spleen (49) (49) (50) Angiectasis 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 14 (29%) 14 (29%) 15 (30%) Hyperplasia, Lymphoid 2 (4%) 2 (4%) 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Pigmentation, Melanin 1 (2%) Thymus (29) (26) (25) Atrophy 4 (14%) 1 (4%) 5 (20%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (49) (50) (50) Inflammation, Chronic Active 1 (2%) 1 (2%) Epidermis, Hyperplasia 2 (4%) Prepuce, Inflammation, Chronic Active 11 (22%) 13 (26%) 16 (32%) Subcutaneous Tissue, Edema 1 (2%) Subcutaneous Tissue, Hemorrhage 1 (2%) Subcutaneous Tissue, Infiltration Cellular, Mast Cell 1 (2%) Subcutaneous Tissue, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) Fibrous Osteodystrophy 1 (2%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (49) (50) Developmental Malformation 1 (2%) Hemorrhage 1 (2%) Hydrocephalus 1 (2%) Artery, Inflammation, Chronic Active 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (49) (50) Hyperplasia 4 (8%) 7 (14%) 15 (30%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 6 (12%) 7 (14%) 7 (14%) Inflammation, Suppurative 1 (2%) 5 (10%) 4 (8%) Epiglottis, Hyperplasia 1 (2%) 2 (4%) 2 (4%) Epiglottis, Metaplasia, Squamous 2 (4%) 1 (2%) 10 (20%) Lung (49) (49) (50) Angiectasis 1 (2%) Hemorrhage 1 (2%) Inflammation, Chronic, Focal 1 (2%) Alveolar Epithelium, Hyperplasia 10 (20%) 8 (16%) 1 (2%) Alveolar Epithelium, Metaplasia 48 (98%) 47 (94%) Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 40 (82%) 41 (82%) Bronchiole, Metaplasia 1 (2%) Bronchiole, Necrosis 1 (2%) Perivascular, Infiltration Cellular 1 (2%) 3 (6%) Nose (49) (48) (49) Lateral Wall, Degeneration, Hyaline 2 (4%) 48 (100%) 49 (100%) Lateral Wall, Fibrosis 8 (17%) 43 (88%) Lateral Wall, Hyperplasia 2 (4%) 33 (69%) 45 (92%) Lateral Wall, Inflammation, Suppurative 1 (2%) 38 (79%) 46 (94%) Lateral Wall, Metaplasia, Squamous 1 (2%) 2 (4%) 20 (41%) Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%) Olfactory Epithelium, Atrophy 4 (8%) 4 (8%) 18 (37%) Trachea (49) (49) (49) Hyperplasia 1 (2%) Metaplasia, Squamous 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (1) (1) Inflammation 2 (67%) 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (49) (49) (50) Cyst 4 (8%) 1 (2%) 3 (6%) Hydronephrosis 1 (2%) Infarct 1 (2%) 1 (2%) Mineralization 2 (4%) Nephropathy 40 (82%) 43 (88%) 37 (74%) Cortex, Inflammation, Suppurative 2 (4%) 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 88034-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:21:59 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 0.5 PPM 1.0 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Papilla, Inflammation, Suppurative 3 (6%) 6 (12%) 6 (12%) Papilla, Necrosis 1 (2%) Pelvis, Dilatation 2 (4%) 1 (2%) Renal Tubule, Hyperplasia 1 (2%) Urinary Bladder (47) (49) (48) Calculus Gross Observation 3 (6%) Inflammation, Chronic Active 2 (4%) 1 (2%) 2 (4%) Inflammation, Suppurative 1 (2%) 5 (10%) 5 (10%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------