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TDMS Study 88034-06 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               OZONE


NTP Experiment-Test: 88034-06                                                                                     Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                                                                      Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  03/09/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           25           33                                                  
    Natural Death                                      7           13            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           12           10                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (43)         (38)         (44)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Intestine Large, Cecum                             (45)         (43)         (47)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Duodenum                          (45)         (41)         (46)                                                
      Peyer's Patch, Histiocytic Sarcoma                                         1 (2%)                                             
   Intestine Small, Jejunum                           (44)         (42)         (47)                                                
   Intestine Small, Ileum                             (45)         (43)         (46)                                                
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (49)         (50)         (50)                                                
      Hemangiosarcoma                                               1 (2%)       2 (4%)                                             
      Hepatocellular Carcinoma                        15 (31%)     15 (30%)      6 (12%)                                            
      Hepatocellular Carcinoma, Multiple               4 (8%)       3 (6%)       2 (4%)                                             
      Hepatocellular Adenoma                          11 (22%)     12 (24%)      9 (18%)                                            
      Hepatocellular Adenoma, Multiple                 2 (4%)       4 (8%)       4 (8%)                                             
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                              3 (6%)                    2 (4%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (13)         (5)          (10)                                                
      Hemangiosarcoma                                               1 (20%)                                                         
      Histiocytic Sarcoma                                                        1 (10%)                                            
      Sarcoma, Metastatic, Skin                        1 (8%)                                                                       
   Pancreas                                           (48)         (48)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Salivary Glands                                    (50)         (48)         (49)                                                
      Sarcoma                                          1 (2%)                                                                       
   Stomach, Forestomach                               (48)         (50)         (49)                                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (49)         (48)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Tooth                                              (1)                                                                           
      Adamantinoma Malignant                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (48)         (49)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Capsule, Adenoma                                 1 (2%)                                                                       
   Adrenal Medulla                                    (48)         (49)         (50)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       2 (4%)       1 (2%)                                             
   Islets, Pancreatic                                 (47)         (47)         (48)                                                
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (48)         (48)         (49)                                                
      Pars Distalis, Adenoma                          19 (40%)     11 (23%)     12 (24%)                                            
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                    3 (6%)                                             
   Thyroid Gland                                      (49)         (49)         (50)                                                
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma, Multiple               2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (48)         (50)                                                
      Cystadenoma                                      4 (8%)       2 (4%)       2 (4%)                                             
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Hemangioma                                       1 (2%)                    2 (4%)                                             
      Histiocytic Sarcoma                              2 (4%)                    2 (4%)                                             
      Luteoma                                          1 (2%)       1 (2%)       1 (2%)                                             
   Uterus                                             (49)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibroma                                          1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Hemangioma                                       1 (2%)                    2 (4%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              3 (6%)                    1 (2%)                                             
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                    3 (6%)       2 (4%)       6 (12%)                                            
      Polyp Stromal, Multiple                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       3 (6%)       1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
   Lymph Node                                         (15)         (6)          (9)                                                 
      Iliac, Histiocytic Sarcoma                       2 (13%)                                                                      
      Pancreatic, Histiocytic Sarcoma                  1 (7%)                                                                       
      Renal, Histiocytic Sarcoma                       1 (7%)                    1 (11%)                                            
   Lymph Node, Bronchial                              (36)         (32)         (33)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (3%)                                                          
      Histiocytic Sarcoma                              1 (3%)                    1 (3%)                                             
   Lymph Node, Mandibular                             (38)         (40)         (41)                                                
      Histiocytic Sarcoma                              2 (5%)                                                                       
   Lymph Node, Mesenteric                             (45)         (48)         (44)                                                
      Histiocytic Sarcoma                              3 (7%)                    1 (2%)                                             
   Lymph Node, Mediastinal                            (43)         (36)         (38)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (3%)                                                          
      Histiocytic Sarcoma                              2 (5%)                    1 (3%)                                             
   Spleen                                             (49)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)       3 (6%)       3 (6%)                                             
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Thymus                                             (35)         (35)         (33)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        3 (6%)       2 (4%)       2 (4%)                                             
      Carcinoma, Multiple                                                        1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Schwannoma Malignant                                          1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       2 (4%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       2 (4%)       5 (10%)                                            
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Osteosarcoma                                     2 (4%)       1 (2%)                                                          
   Skeletal Muscle                                                              (2)                                                 
      Histiocytic Sarcoma                                                        1 (50%)                                            
      Rhabdomyosarcoma                                                           1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (49)         (50)                                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Adamantinoma Malignant, Metastatic, Tooth        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     3 (6%)       3 (6%)      10 (20%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       5 (10%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)                                                                       
      Carcinoma, Metastatic, Harderian Gland           1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       5 (10%)      1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                              2 (4%)                    2 (4%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            2 (4%)                                                                       
      Mediastinum, Hemangiosarcoma                                  1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
      Mediastinum, Osteosarcoma, Metastatic, Bone                   1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Skin                        1 (2%)                                                          
   Nose                                               (50)         (49)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
                                                             Page   5                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (5)          (3)                                                 
      Adenoma                                          4 (80%)      4 (80%)      2 (67%)                                            
      Carcinoma                                        1 (20%)      1 (20%)      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (47)         (48)         (46)                                                
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              4 (8%)                    3 (6%)                                             
      Lymphoma Malignant                              13 (26%)     12 (24%)     13 (26%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          49          47                                                   
     Total Primary Neoplasms                          115         100         105                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          32          35                                                   
     Total Benign Neoplasms                            62          43          59                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          39          34                                                   
     Total Malignant Neoplasms                         53          57          46                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8          10           2                                                   
     Total Metastatic Neoplasm                         17          17           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     10            9           15                                                  
    Moribund Sacrifice                                26           30           23                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           11           12                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (44)         (45)         (40)                                                
      Carcinoma                                                                  1 (3%)                                             
   Intestine Small, Duodenum                          (44)         (45)         (38)                                                
   Intestine Small, Jejunum                           (43)         (44)         (41)                                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Intestine Small, Ileum                             (44)         (45)         (40)                                                
   Liver                                              (49)         (50)         (50)                                                
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         7 (14%)     14 (28%)     14 (28%)                                            
      Hepatocellular Carcinoma, Multiple              13 (27%)      3 (6%)       7 (14%)                                            
      Hepatocellular Adenoma                           6 (12%)     12 (24%)     11 (22%)                                            
      Hepatocellular Adenoma, Multiple                 7 (14%)      6 (12%)      1 (2%)                                             
      Hepatocholangiocarcinoma                                                   2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Seminal Vesicle             1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                       1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
   Mesentery                                          (3)          (3)          (4)                                                 
      Hemangioma                                                    1 (33%)                                                         
      Hemangiosarcoma                                               1 (33%)                                                         
      Sarcoma, Metastatic, Seminal Vesicle             1 (33%)                                                                      
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (33%)                                                                      
   Oral Mucosa                                                     (1)                                                              
      Pharyngeal, Squamous Cell Carcinoma                           1 (100%)                                                        
   Pancreas                                           (49)         (49)         (49)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                 1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (49)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)                                                
      Sarcoma, Metastatic, Seminal Vesicle             1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (4%)                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (47)         (48)                                                
      Sarcoma, Metastatic, Seminal Vesicle             1 (2%)                                                                       
   Tooth                                                                        (1)                                                 
      Odontoma                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (47)         (49)         (49)                                                
      Adenoma                                          2 (4%)       1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Sarcoma, Metastatic, Seminal Vesicle             1 (2%)                                                                       
   Adrenal Medulla                                    (48)         (48)         (49)                                                
      Pheochromocytoma Benign                          1 (2%)                                                                       
      Sarcoma, Metastatic, Seminal Vesicle             1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (49)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (47)         (49)         (48)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Pars Distalis, Adenoma                                        1 (2%)                                                          
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
   Thyroid Gland                                      (49)         (48)         (50)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (49)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Preputial Gland                                    (49)         (49)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Prostate                                           (48)         (47)         (47)                                                
   Seminal Vesicle                                    (48)         (49)         (49)                                                
      Sarcoma                                          1 (2%)                                                                       
   Testes                                             (50)         (49)         (50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Interstitial Cell, Adenoma                       2 (4%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       2 (4%)       2 (4%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Femoral, Mast Cell Tumor NOS                                               1 (2%)                                             
   Lymph Node                                         (2)          (3)          (7)                                                 
   Lymph Node, Bronchial                              (26)         (27)         (32)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (3%)                                             
   Lymph Node, Mandibular                             (34)         (31)         (32)                                                
   Lymph Node, Mesenteric                             (48)         (46)         (44)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Lymph Node, Mediastinal                            (37)         (39)         (43)                                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
   Spleen                                             (49)         (49)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       3 (6%)       4 (8%)                                             
      Mast Cell Tumor NOS                                                        1 (2%)                                             
   Thymus                                             (29)         (26)         (25)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Sarcoma                                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (2)                       (1)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (50%)                                                                      
      Sarcoma, Metastatic, Seminal Vesicle             1 (50%)                                                                      
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (49)         (50)                                                
      Choristoma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      8 (16%)      8 (16%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   6 (12%)     10 (20%)     14 (28%)                                            
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       5 (10%)      4 (8%)                                             
      Carcinoma, Metastatic, Harderian Gland                        2 (4%)       1 (2%)                                             
      Carcinoma, Metastatic, Salivary Glands           1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      6 (12%)      4 (8%)       7 (14%)                                            
      Hepatocholangiocarcinoma, Metastatic, Liver                                2 (4%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)       1 (2%)                                                          
      Mediastinum, Hemangioma                                       1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
   Nose                                               (49)         (48)         (49)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (7)          (8)          (5)                                                 
      Adenoma                                          6 (86%)      5 (63%)      4 (80%)                                            
      Carcinoma                                                     2 (25%)      1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (47)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant                               2 (4%)       3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 88034-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:21:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          50          42                                                   
     Total Primary Neoplasms                           78          90          88                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          32          23                                                   
     Total Benign Neoplasms                            37          37          31                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          41          40                                                   
     Total Malignant Neoplasms                         40          53          55                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             11           7          12                                                   
     Total Metastatic Neoplasm                         25           7          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                       1                                                   
     Total Uncertain Neoplasms                          1                       2                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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