TDMS Study 88034-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE TIME: 22:35:39
TEST: 06 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034B
CONT: N01-ES-95239 CAS: 10028-15-6
PATHOLOGIST: S. GRUMBEIN
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 05/08/95
EXP: 88034 OZONE TIME: 22:35:39
TEST: 06 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 88034B
CONT: N01-ES-95239 CAS: 10028-15-6
PATHOLOGIST: S. GRUMBEIN
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 911 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 95 328 387 391 392 454 482 527 578 605 |
| 665 693 694 701 707 721 722 749 767 778 |
| 781 791 805 807 807 807 810 817 840 845 |
| 847 869 882 883 901 903 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 386 446 471 568 610 616 632 649 651 678 |
| 678 693 693 707 709 716 721 721 722 735 |
| 735 773 787 791 798 799 804 805 812 823 |
| 826 838 845 847 847 869 875 880 901 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 297 408 435 469 550 561 572 581 609 616 |
| 620 623 628 665 670 677 677 678 685 719 |
| 730 732 741 749 778 786 791 807 807 808 |
| 812 819 828 832 838 874 875 877 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 911 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 911 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 96.0 90.0 86.0 84.0 80.0 78.0 28.0 |
| | |
| | |
|0.5 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 94.0 92.0 82.0 22.0 |
| | |
| | |
|1.0 PPM | 100.0 100.0 100.0 98.0 96.0 92.0 92.0 84.0 72.0 24.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 PPM 1.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 28.0% 22.0% 24.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.440 P=0.603 P=0.519 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 689.8 729.7 690.1 |
|NATURAL DEATHS (C) | (32.0) (19.3) (22.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 751.7 769.6 743.1 |
|(STANDARD ERROR) | (27.0) (18.4) (21.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 911 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 403 408 521 527 537 547 556 621 678 717 |
| 721 721 722 724 749 749 754 775 778 790 |
| 791 791 791 796 801 805 824 826 826 840 |
| 840 841 847 849 857 860 865 869 875 883 |
| 884 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 544 571 595 616 616 621 623 678 691 721 |
| 726 750 754 763 766 775 784 785 786 792 |
| 792 805 807 817 821 826 855 855 855 861 |
| 863 874 875 875 877 880 880 883 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 40 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 416 455 530 559 586 588 646 647 651 660 |
| 665 678 680 693 696 697 703 722 735 741 |
| 749 749 755 767 774 778 786 833 835 847 |
| 847 852 855 869 869 874 874 880 903 903 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OZONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 911 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 911 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.0 96.0 90.0 86.0 84.0 18.0 |
| | |
| | |
|0.5 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 86.0 24.0 |
| | |
| | |
|1.0 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 88.0 78.0 20.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 PPM 1.0 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 18.0% 24.0% 20.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=0.377N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 745.3 769.9 733.7 |
|NATURAL DEATHS (C) | (20.2) (16.1) (19.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 775.2 803.8 769.1 |
|(STANDARD ERROR) | (18.8) (14.9) (18.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OZONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 PPM = 2
1.0 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
102 +
| 1 1 3 2
| 1 3 1 2 3 2
| 1 1 3 32 2
94 + 3 32 2
| 3 3 2 2
| 1 1 3 3
| 1 1 33 2 2
86 + 1 1 3 2 2
| 1 1 3
| 1 13 2 2
| 133 1
P 78 + 1 21
E | 33 11
R | 3 3 211
C | 33 22
E 70 + 33 11
N | 11
T | 1 1
| 33 22 1 1
S 62 + 3 322 11
U | 3 3
R | 2 211
V | 33 2 11
I 54 + 3 11
V | 3 322
A | 332
L |
46 + 3 11
| 221 1
| 2 211
|
38 + 33221 1
| 3322 11
| 1
| 33 1 1
30 + 32 2
| 11
| 22
| 2 23
22 + 22
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 18 obs hidden.
OZONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 PPM = 2
1.0 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
112 +
|
|
| 1 13 3 2 2
P 96 + 1 3 11 3 2 2 2
E | 1113 3 22
R | 11 3 1 3 2
C | 1 33 12 1
E 80 + 3 3 22 2
N | 33 11 22
T | 33 1 1 22
| 33 3 11 122
S 64 + 333 1112
U | 3 2
R | 33 3 1122
V | 33 1 22
I 48 + 331 1 2
V | 113
A | 11222
L | 11 3
32 + 1 22
| 1112
| 11 32
| 1 31
16 +
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 57 obs hidden.