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TDMS Study 88034-06 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 05/08/95   
EXP: 88034                          OZONE                      TIME: 22:35:39   
TEST: 06              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 88034B   
CONT: N01-ES-95239                                             CAS: 10028-15-6  
PATHOLOGIST: S. GRUMBEIN                                                        
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 05/08/95  
EXP: 88034                          OZONE                      TIME: 22:35:39  
TEST: 06              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC 30-MONTH ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 88034B  
CONT: N01-ES-95239                                             CAS: 10028-15-6 
PATHOLOGIST: S. GRUMBEIN                                                       

                                       OZONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 911 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      95    328   387   391   392   454   482   527   578   605                 |
 |      665   693   694   701   707   721   722   749   767   778                 |
 |      781   791   805   807   807   807   810   817   840   845                 |
 |      847   869   882   883   901   903                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      386   446   471   568   610   616   632   649   651   678                 |
 |      678   693   693   707   709   716   721   721   722   735                 |
 |      735   773   787   791   798   799   804   805   812   823                 |
 |      826   838   845   847   847   869   875   880   901                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      297   408   435   469   550   561   572   581   609   616                 |
 |      620   623   628   665   670   677   677   678   685   719                 |
 |      730   732   741   749   778   786   791   807   807   808                 |
 |      812   819   828   832   838   874   875   877                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                       OZONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 911 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   911 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.0  98.0  96.0  90.0  86.0  84.0  80.0  78.0  28.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5 PPM    |   100.0 100.0 100.0 100.0  98.0  94.0  94.0  92.0  82.0  22.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0 PPM    |   100.0 100.0 100.0  98.0  96.0  92.0  92.0  84.0  72.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.5 PPM          1.0 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       28.0%            22.0%            24.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.440          P=0.603          P=0.519       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       689.8            729.7            690.1         |
 |NATURAL DEATHS (C)      |       (32.0)           (19.3)           (22.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       751.7            769.6            743.1         |
 |(STANDARD ERROR)        |       (27.0)           (18.4)           (21.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                       OZONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 911 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 41     CENSORED DEATHS 0    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      403   408   521   527   537   547   556   621   678   717                 |
 |      721   721   722   724   749   749   754   775   778   790                 |
 |      791   791   791   796   801   805   824   826   826   840                 |
 |      840   841   847   849   857   860   865   869   875   883                 |
 |      884                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.5 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 38     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      544   571   595   616   616   621   623   678   691   721                 |
 |      726   750   754   763   766   775   784   785   786   792                 |
 |      792   805   807   817   821   826   855   855   855   861                 |
 |      863   874   875   875   877   880   880   883                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      416   455   530   559   586   588   646   647   651   660                 |
 |      665   678   680   693   696   697   703   722   735   741                 |
 |      749   749   755   767   774   778   786   833   835   847                 |
 |      847   852   855   869   869   874   874   880   903   903                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                       OZONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 911 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   911 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  96.0  96.0  90.0  86.0  84.0  18.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.5 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  94.0  86.0  24.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.0 PPM    |   100.0 100.0 100.0 100.0  98.0  96.0  94.0  88.0  78.0  20.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.5 PPM          1.0 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       18.0%            24.0%            20.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000N         P=0.377N         P=1.000N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       745.3            769.9            733.7         |
 |NATURAL DEATHS (C)      |       (20.2)           (16.1)           (19.2)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       775.2            803.8            769.1         |
 |(STANDARD ERROR)        |       (18.8)           (14.9)           (18.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                               OZONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.5 PPM          = 2
                                                        1.0 PPM          = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

             |
             |
         102 +
             |  1          1                    3         2
             |             1                    3  1      2 3   2
             |                                     1      1 3  32  2
          94 +                                                 3  32          2
             |                                                    3        3  2   2
             |                                            1      1         3 3
             |                                                   1  1        33   2 2
          86 +                                                      1    1    3     2 2
             |                                                           1    1  3
             |                                                                1  13   2  2
             |                                                                   133   1
       P  78 +                                                                         1 21
       E     |                                                                     33     11
       R     |                                                                      3  3  211
       C     |                                                                         33   22
       E  70 +                                                                          33  11
       N     |                                                                               11
       T     |                                                                                1 1
             |                                                                           33  22 1  1
       S  62 +                                                                            3  322   11
       U     |                                                                               3 3
       R     |                                                                                 2   211
       V     |                                                                                 33  2 11
       I  54 +                                                                                  3     11
       V     |                                                                                  3   322
       A     |                                                                                      332
       L     |
          46 +                                                                                       3 11
             |                                                                                        221 1
             |                                                                                         2 211
             |
          38 +                                                                                         33221  1
             |                                                                                          3322  11
             |                                                                                                 1
             |                                                                                           33    1 1
          30 +                                                                                            32  2
             |                                                                                                   11
             |                                                                                                22
             |                                                                                                 2 23
          22 +                                                                                                   22
             |
             ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
                0             20             40             60             80             100            120            140

                                                                   WEEK

NOTE: 18 obs hidden.

                                                               OZONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.5 PPM          = 2
                                                        1.0 PPM          = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

             |
             |
         112 +
             |
             |
             |  1                                           13   3         2  2
       P  96 +                                              1    3      11  3 2 2 2
       E     |                                                           1113  3  22
       R     |                                                             11  3   1  3  2
       C     |                                                                     1  33 12  1
       E  80 +                                                                         3 3   22  2
       N     |                                                                           33  11  22
       T     |                                                                            33  1 1 22
             |                                                                             33 3 11 122
       S  64 +                                                                                333  1112
       U     |                                                                                  3     2
       R     |                                                                                  33 3 1122
       V     |                                                                                     33 1 22
       I  48 +                                                                                      331  1  2
       V     |                                                                                           113
       A     |                                                                                            11222
       L     |                                                                                             11 3
          32 +                                                                                              1 22
             |                                                                                              1112
             |                                                                                                11 32
             |                                                                                                 1 31
          16 +
             |
             ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
                0             20             40             60             80             100            120            140

                                                                   WEEK

NOTE: 57 obs hidden.