TDMS Study 88034-05 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
OZONE
NTP Experiment-Test: 88034-05 Report: PEIRPT03
Study Type: CHRONIC 30-MONTH Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
Facility: Battelle Northwest
Chemical CAS #: 10028-15-6
Lock Date: 03/24/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 56 56 56
Scheduled Sacrifice 6 6 6
Early Deaths
Moribund Sacrifice 36 37 40
Natural Death 8 7 3
Survivors
Terminal Sacrifice 6 6 7
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (50)
Parasite Metazoan 3 (6%) 5 (10%) 4 (8%)
Intestine Large, Rectum (48) (50) (47)
Parasite Metazoan 2 (4%) 4 (8%) 5 (11%)
Intestine Large, Cecum (48) (49) (50)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 3 (6%) 3 (6%) 5 (10%)
Intestine Small, Jejunum (47) (47) (49)
Hyperplasia, Adenomatous 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%) 7 (14%) 3 (6%)
Basophilic Focus 37 (74%) 39 (78%) 42 (84%)
Clear Cell Focus 1 (2%) 5 (10%) 5 (10%)
Degeneration, Cystic 5 (10%)
Degeneration, Fatty 18 (36%) 22 (44%) 11 (22%)
Eosinophilic Focus 3 (6%) 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 7 (14%) 12 (24%)
Inflammation, Granulomatous 2 (4%)
Mixed Cell Focus 11 (22%) 8 (16%) 9 (18%)
Necrosis 2 (4%) 3 (6%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 15 (30%) 12 (24%) 10 (20%)
Centrilobular, Necrosis 8 (16%) 5 (10%) 5 (10%)
Mesentery (11) (7) (4)
Inflammation, Chronic Active 1 (9%)
Artery, Inflammation, Chronic Active 1 (14%)
Artery, Mineralization 1 (9%) 1 (14%)
Fat, Necrosis 6 (55%) 6 (86%) 4 (100%)
Oral Mucosa (2) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Gingival, Cyst 1 (50%)
Pancreas (49) (49) (50)
Atrophy 20 (41%) 14 (29%) 21 (42%)
Basophilic Focus 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50)
Basophilic Focus 1 (2%)
Stomach, Forestomach (49) (50) (50)
Hyperplasia, Squamous 2 (4%) 3 (6%)
Mineralization 1 (2%)
Necrosis 11 (22%) 9 (18%) 7 (14%)
Stomach, Glandular (49) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 3 (6%) 2 (4%) 4 (8%)
Necrosis 2 (4%) 2 (4%) 1 (2%)
Tongue (1) (1)
Hyperplasia 1 (100%)
Tooth (1)
Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (1)
Aorta, Mineralization 1 (100%) 1 (100%) 1 (100%)
Heart (50) (50) (50)
Cardiomyopathy 30 (60%) 35 (70%) 35 (70%)
Artery, Mineralization 1 (2%) 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50)
Atrophy 1 (2%) 3 (6%) 1 (2%)
Hyperplasia 19 (38%) 25 (51%) 22 (44%)
Hypertrophy 6 (12%) 5 (10%) 6 (12%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 9 (18%) 7 (14%) 8 (16%)
Adrenal Medulla (50) (49) (50)
Hyperplasia 12 (24%) 18 (37%) 13 (26%)
Islets, Pancreatic (49) (49) (50)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (44)
Hyperplasia 4 (8%) 2 (4%) 2 (5%)
Pituitary Gland (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 3 (6%) 5 (10%) 10 (20%)
Thyroid Gland (50) (49) (50)
C-Cell, Hyperplasia 37 (74%) 38 (78%) 30 (60%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (48) (47)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 4 (9%) 3 (6%) 2 (4%)
Ovary (50) (50) (50)
Cyst 3 (6%) 3 (6%)
Hyperplasia 1 (2%)
Uterus (50) (50) (50)
Cyst 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Atrophy 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Lymph Node (10) (12) (9)
Pancreatic, Inflammation, Granulomatous 1 (8%)
Renal, Hemorrhage 1 (10%) 1 (8%)
Renal, Infiltration Cellular, Plasma Cell 1 (11%)
Renal, Inflammation, Granulomatous 1 (10%)
Lymph Node, Mandibular (47) (44) (46)
Infiltration Cellular, Plasma Cell 4 (9%) 1 (2%) 1 (2%)
Spleen (50) (50) (50)
Depletion Cellular 1 (2%)
Fibrosis 6 (12%) 6 (12%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%)
Hemorrhage 2 (4%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Galactocele 1 (2%) 3 (6%)
Skin (49) (50) (50)
Cyst 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 6 (12%) 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 3 (6%) 2 (4%)
Fracture 1 (2%)
Hyperostosis 2 (4%) 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Gliosis 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (47) (50)
Inflammation, Chronic Active 1 (2%)
Epiglottis, Metaplasia, Squamous 2 (4%) 16 (34%) 48 (96%)
Lung (50) (50) (50)
Congestion, Chronic 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 5 (10%) 2 (4%)
Alveolar Epithelium, Metaplasia 44 (88%) 50 (100%)
Alveolus, Infiltration Cellular, Histiocyte 38 (76%) 49 (98%)
Artery, Infiltration Cellular, Histiocyte 1 (2%)
Artery, Mediastinum, Mineralization 1 (2%) 1 (2%) 1 (2%)
Artery, Perivascular, Inflammation, Chronic 1 (2%)
Interstitium, Fibrosis 41 (82%) 50 (100%)
Nose (50) (49) (50)
Inflammation, Suppurative 6 (12%) 7 (14%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 8 (16%) 7 (14%) 3 (6%)
Goblet Cell, Lateral Wall, Hyperplasia 47 (96%) 50 (100%)
Lateral Wall, Hyperplasia 4 (8%) 49 (100%) 50 (100%)
Lateral Wall, Metaplasia, Squamous 5 (10%) 25 (51%) 35 (70%)
Olfactory Epithelium, Degeneration, Hyaline 48 (96%) 48 (98%) 50 (100%)
Olfactory Epithelium, Metaplasia 3 (6%) 4 (8%)
Trachea (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Cataract 1 (50%)
Degeneration 2 (100%)
Cornea, Inflammation, Chronic Active 1 (100%)
Cornea, Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%)
Infarct 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Nephropathy 49 (98%) 47 (94%) 49 (98%)
Thrombosis 1 (2%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 56 56 56
Scheduled Sacrifice 6 6 6
Early Deaths
Moribund Sacrifice 47 43 42
Natural Death 3 7 7
Survivors
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (49)
Mineralization 5 (10%)
Parasite Metazoan 2 (4%) 2 (4%) 3 (6%)
Intestine Large, Rectum (50) (50) (49)
Parasite Metazoan 3 (6%) 2 (4%)
Intestine Large, Cecum (49) (50) (49)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%)
Parasite Metazoan 3 (6%) 5 (10%) 4 (8%)
Artery, Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (48) (49)
Inflammation, Acute 2 (4%)
Intestine Small, Ileum (49) (47) (48)
Inflammation, Acute 1 (2%)
Mineralization 3 (6%)
Liver (50) (50) (50)
Angiectasis 2 (4%) 6 (12%) 3 (6%)
Basophilic Focus 23 (46%) 18 (36%) 23 (46%)
Clear Cell Focus 1 (2%)
Degeneration, Cystic 15 (30%) 13 (26%) 16 (32%)
Degeneration, Fatty 14 (28%) 13 (26%) 9 (18%)
Eosinophilic Focus 1 (2%) 1 (2%) 5 (10%)
Hepatodiaphragmatic Nodule 3 (6%) 2 (4%) 6 (12%)
Infiltration Cellular, Mixed Cell 1 (2%)
Mixed Cell Focus 3 (6%) 2 (4%) 1 (2%)
Necrosis 1 (2%) 4 (8%) 3 (6%)
Thrombosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 39 (78%) 38 (76%) 29 (58%)
Centrilobular, Necrosis 7 (14%) 10 (20%) 6 (12%)
Mesentery (16) (17) (7)
Inflammation, Chronic Active 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic Active 1 (6%)
Artery, Mineralization 6 (38%) 3 (18%)
Fat, Hemorrhage 1 (14%)
Fat, Necrosis 8 (50%) 10 (59%) 4 (57%)
Oral Mucosa (4)
Gingival, Hyperplasia, Squamous 1 (25%)
Pancreas (50) (50) (50)
Atrophy 28 (56%) 28 (56%) 28 (56%)
Basophilic Focus 1 (2%) 2 (4%)
Hyperplasia 3 (6%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 2 (4%)
Salivary Glands (50) (49) (50)
Artery, Mineralization 1 (2%)
Duct, Metaplasia, Squamous 1 (2%)
Stomach, Forestomach (50) (50) (50)
Diverticulum 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (2%) 2 (4%)
Mineralization 7 (14%) 2 (4%)
Necrosis 9 (18%) 10 (20%) 5 (10%)
Stomach, Glandular (50) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 13 (26%) 7 (14%) 6 (12%)
Necrosis 6 (12%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (9) (4) (4)
Aorta, Mineralization 9 (100%) 4 (100%) 4 (100%)
Heart (50) (50) (50)
Cardiomyopathy 40 (80%) 44 (88%) 39 (78%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Artery, Mineralization 8 (16%) 6 (12%) 2 (4%)
Atrium, Thrombosis 7 (14%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50)
Atrophy 1 (2%) 2 (4%)
Hyperplasia 18 (36%) 22 (45%) 25 (50%)
Hypertrophy 7 (14%) 5 (10%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 5 (10%) 2 (4%) 4 (8%)
Adrenal Medulla (50) (49) (50)
Hyperplasia 21 (42%) 19 (39%) 14 (28%)
Islets, Pancreatic (50) (50) (50)
Hyperplasia 2 (4%) 4 (8%) 3 (6%)
Parathyroid Gland (49) (50) (50)
Hyperplasia 15 (31%) 10 (20%) 12 (24%)
Pituitary Gland (50) (48) (50)
Hemorrhage 1 (2%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 7 (14%) 9 (19%) 8 (16%)
Pars Distalis, Necrosis 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Hyperplasia 28 (56%) 29 (58%) 22 (44%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Granuloma Sperm 2 (4%) 1 (2%)
Penis (4) (4) (1)
Inflammation, Acute 1 (25%) 2 (50%)
Preputial Gland (50) (48) (50)
Inflammation, Chronic Active 5 (10%) 2 (4%) 6 (12%)
Prostate (50) (50) (50)
Hyperplasia 6 (12%) 1 (2%) 4 (8%)
Inflammation, Chronic Active 10 (20%) 3 (6%) 4 (8%)
Seminal Vesicle (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Mineralization 3 (6%) 2 (4%)
Testes (50) (50) (50)
Atrophy 9 (18%) 5 (10%) 1 (2%)
Artery, Inflammation, Chronic Active 4 (8%) 3 (6%) 3 (6%)
Artery, Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 10 (20%) 4 (8%) 10 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (20) (13) (13)
Iliac, Infiltration Cellular, Plasma Cell 1 (8%)
Lumbar, Hemorrhage 1 (8%)
Renal, Hemorrhage 7 (35%) 4 (31%)
Renal, Pigmentation 1 (8%)
Lymph Node, Bronchial (36) (37) (36)
Hemorrhage 1 (3%)
Lymph Node, Mandibular (48) (47) (47)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 3 (6%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (49) (49) (49)
Ectasia 1 (2%)
Lymph Node, Mediastinal (45) (48) (47)
Hemorrhage 2 (4%)
Spleen (50) (50) (50)
Fibrosis 16 (32%) 6 (12%) 13 (26%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (31) (21) (26)
Galactocele 4 (13%) 1 (4%)
Hyperplasia, Atypical 1 (3%)
Inflammation, Chronic Active 1 (3%)
Skin (50) (50) (49)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 4 (8%)
Inflammation, Chronic Active 16 (32%) 3 (6%) 5 (10%)
Prepuce, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 15 (30%) 8 (16%) 5 (10%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Hemorrhage 2 (4%)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Meninges, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48) (47)
Mineralization 5 (10%) 1 (2%)
Epiglottis, Metaplasia, Squamous 20 (42%) 43 (91%)
Lung (50) (50) (50)
Congestion, Chronic 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 3 (6%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 10 (20%) 6 (12%) 4 (8%)
Necrosis 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 4 (8%) 6 (12%)
Alveolar Epithelium, Metaplasia 45 (90%) 50 (100%)
Alveolus, Infiltration Cellular, Histiocyte 38 (76%) 49 (98%)
Artery, Mediastinum, Mineralization 7 (14%) 1 (2%) 1 (2%)
Artery, Mediastinum, Thrombosis 1 (2%)
Interstitium, Fibrosis 44 (88%) 50 (100%)
Nose (50) (49) (49)
Inflammation, Suppurative 14 (28%) 13 (27%) 18 (37%)
Thrombosis 11 (22%) 6 (12%) 3 (6%)
Goblet Cell, Lateral Wall, Hyperplasia 1 (2%) 46 (94%) 48 (98%)
Lateral Wall, Hyperplasia 10 (20%) 48 (98%) 47 (96%)
Lateral Wall, Metaplasia, Squamous 10 (20%) 23 (47%) 40 (82%)
Olfactory Epithelium, Degeneration, Hyaline 49 (98%) 49 (100%) 49 (100%)
Olfactory Epithelium, Metaplasia 5 (10%) 1 (2%)
Trachea (50) (50) (50)
Mineralization 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (3)
Cataract 1 (50%) 2 (67%)
Degeneration 1 (100%) 1 (50%) 2 (67%)
Retina, Atrophy 1 (50%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88034-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 30-MONTH OZONE Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:42:15
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.5 PPM 1.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Harderian Gland (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 3 (6%) 3 (6%) 3 (6%)
Hyperplasia, Oncocytic 1 (2%)
Mineralization 10 (20%) 5 (10%) 2 (4%)
Nephropathy 50 (100%) 49 (98%) 50 (100%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 6 (12%) 4 (8%) 3 (6%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
Urinary Bladder (50) (50) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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