TDMS Study 88034-05 Pathology Tables
NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 03/24/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Adenoma, Multiple | | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + M + +| Adenoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leukemia Mononuclear | X X X | Polyp Stromal | X X | Polyp Stromal, Multiple | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + + +| Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X X X X X| Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + M + + + + M + + + + + M M M + M + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + M + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + M| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + M + +| Keratoacanthoma | | Schwannoma Malignant, Metastatic, | | Uterus | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Glioma Benign | X | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Spinal Cord | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Mammary Gland | X | Carcinoma, Metastatic, Adrenal Cortex| | Leukemia Mononuclear | X X X X X X X X X X X| Squamous Cell Carcinoma | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X| Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + A + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + A + + + + + A + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Oral Mucosa | + | Gingival, Squamous Cell Carcinoma | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Adenoma, Multiple | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + I + + M + +| Adenoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Leukemia Mononuclear | | Polyp Stromal | X X | Polyp Stromal, Multiple | X | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + M M M + + + M M M M + + + + + M| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + I + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + M + + + + M + + + M M + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + + + + I M + + + + M + + + + + + M + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Carcinoma | X X | Carcinoma, Multiple | | Fibroadenoma | X X X X | Fibroadenoma, Multiple | X X X X X X X| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Schwannoma Malignant, Metastatic, | | Uterus | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Glioma Benign | | Leukemia Mononuclear | X | __________________________________________________________________________| Spinal Cord | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Mammary Gland | | Carcinoma, Metastatic, Adrenal Cortex| X | Leukemia Mononuclear | X X X X X X X | Squamous Cell Carcinoma | | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 47 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 46 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Leukemia Mononuclear | X X | 21 | __________________________________________________________________________|____________| Mesentery | + | 11 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Oral Mucosa | | 2 | Gingival, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 49 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 49 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Leukemia Mononuclear | X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Carcinoma | | 2 | Leukemia Mononuclear | X | 15 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Leukemia Mononuclear | X | 13 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X | 12 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 49 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Leukemia Mononuclear | X | 11 | Pars Distalis, Adenoma | X X X X X X | 44 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Adenoma | | 6 | C-Cell, Adenoma, Multiple | | 1 | C-Cell, Carcinoma | X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + | 45 | Adenoma | | 3 | __________________________________________________________________________|____________| Ovary | + + + + + + | 50 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + | 50 | Carcinoma | | 1 | Leukemia Mononuclear | X | 4 | Polyp Stromal | X | 5 | Polyp Stromal, Multiple | | 1 | Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Lymph Node | | 10 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 2 | Pancreatic, Leukemia Mononuclear | | 6 | Renal, Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M M + + | 27 | Leukemia Mononuclear | X | 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + | 47 | Leukemia Mononuclear | X X | 14 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + | 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 17 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 42 | Leukemia Mononuclear | X X | 14 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Leukemia Mononuclear | X X | 21 | __________________________________________________________________________|____________| Thymus | + + + + + + | 44 | Leukemia Mononuclear | X X | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | Carcinoma | X | 7 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X | 9 | Fibroadenoma, Multiple | | 10 | __________________________________________________________________________|____________| Skin | + + + + + + | 49 | Keratoacanthoma | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | X | 1 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Glioma Benign | | 1 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Adrenal Cortex| | 1 | Leukemia Mononuclear | X X | 20 | Squamous Cell Carcinoma | | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 17 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | Fibrous Histiocytoma, Metastatic, | | Skin | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + | Adenoma | X | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | X X X X X X X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X X X X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + | Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + | Carcinoma | | Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + M + + + + + + + + + + + + + | Adenoma | | Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | Granulosa Cell Tumor Benign | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Polyp Stromal | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + | Leukemia Mononuclear | | Deep Cervical, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + + + + + + + M + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + A M + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + M + + + + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + M + + + + + + + + M + + + M + + + + + + + + | Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | Carcinoma | X X X X | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + A + + + + | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinum, Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | A + | __________________________________________________________________________| Zymbal's Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Leukemia Mononuclear | X X X X X X X X X X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + I + + + + + + + + + + + | Fibrous Histiocytoma, Metastatic, | | Skin | | Leukemia Mononuclear | X X X | Transitional Epithelium, Carcinoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Leukemia Mononuclear | X| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A +| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Mesentery | + + +| __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X X X X X| Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + +| Adenoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Leukemia Mononuclear | | C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Polyp Stromal | X | __________________________________________________________________________| Vagina | +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node | + + + + +| Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X X| Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + M + + + + + + M + M + M + + M + +| Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + M + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + A + + + + + + + + + + + + + I + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Leukemia Mononuclear | X X X X X X X| Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma, Metastatic, | | Skin | X | Leukemia Mononuclear | X X X | Transitional Epithelium, Carcinoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | Leukemia Mononuclear | | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 47 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 47 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 22 | __________________________________________________________________________|____________| Mesentery | | 7 | __________________________________________________________________________|____________| Oral Mucosa | | 2 | Pharyngeal, Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + | 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Leukemia Mononuclear | X | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 49 | Adenoma | | 1 | Leukemia Mononuclear | X X | 17 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 49 | Leukemia Mononuclear | X X | 16 | Pheochromocytoma Complex | X | 1 | Pheochromocytoma Benign | | 14 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Carcinoma | | 1 | Leukemia Mononuclear | X | 9 | Pars Distalis, Adenoma | X X X | 40 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 6 | C-Cell, Carcinoma | | 3 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 48 | Adenoma | | 3 | Carcinoma | | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + | 50 | Granulosa Cell Tumor Benign | | 1 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Uterus | + + + + + | 50 | Leukemia Mononuclear | | 3 | Polyp Stromal | X X | 3 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 49 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 14 | __________________________________________________________________________|____________| Lymph Node | + | 12 | Leukemia Mononuclear | | 1 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X | 7 | Renal, Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + | 42 | Leukemia Mononuclear | X | 15 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 44 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 15 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 16 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + | 45 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 15 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 22 | __________________________________________________________________________|____________| Thymus | + + + + + | 47 | Leukemia Mononuclear | X X | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 50 | Carcinoma | | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | X | 18 | Fibroadenoma, Multiple | X X | 10 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 47 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 21 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinum, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + | 49 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 18 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 49 | Fibrous Histiocytoma, Metastatic, | | | Skin | | 1 | Leukemia Mononuclear | X | 7 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | + | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + M + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X X X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M +| Adenoma | X X X | Carcinoma | X X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X X | Sarcoma Stromal | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + | Pancreatic, Leukemia Mononuclear | X X X X | Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | M + M + M M M M + + M + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Sarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma, Multiple | | Carcinoma | X X X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Melanoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Osteoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Chondroma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + I + + + + + I + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X | Sarcoma Stromal | X | Schwannoma Malignant | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node | + + | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + + M M M + + M M + M + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + M + + + + + + + M + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Sarcoma | X | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma, Multiple | X | Carcinoma | X X X | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Osteoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Chondroma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Leukemia Mononuclear | X | 20 | __________________________________________________________________________|____________| Mesentery | | 4 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + | 50 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Leukemia Mononuclear | X | 10 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 12 | Bilateral, Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + | 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | X X X X X | 37 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | Bilateral, C-Cell, Adenoma | X | 1 | C-Cell, Adenoma | | 3 | C-Cell, Carcinoma | | 4 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + | 47 | Adenoma | | 6 | Carcinoma | | 3 | __________________________________________________________________________|____________| Ovary | + + + + + | 50 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Uterus | + + + + + | 50 | Leukemia Mononuclear | | 2 | Polyp Stromal | | 6 | Sarcoma Stromal | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Leukemia Mononuclear | | 13 | __________________________________________________________________________|____________| Lymph Node | + + | 9 | Pancreatic, Leukemia Mononuclear | | 6 | Renal, Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + | 34 | Leukemia Mononuclear | | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + | 46 | Leukemia Mononuclear | X | 12 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | Leukemia Mononuclear | | 14 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 45 | Leukemia Mononuclear | | 10 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Leukemia Mononuclear | X | 20 | Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + | 48 | Leukemia Mononuclear | | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 50 | Adenoma, Multiple | | 1 | Carcinoma | X | 7 | Fibroadenoma | X | 20 | Fibroadenoma, Multiple | | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 2 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Melanoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Osteoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Carcinoma, Metastatic, Thyroid Gland | | 1 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 2 | Leukemia Mononuclear | X | 18 | __________________________________________________________________________|____________| Nose | + + + + + | 50 | Chondroma | | 1 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Leukemia Mononuclear | X | 12 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | Leukemia Mononuclear | X | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + + + + + | Mesothelioma Malignant | | Schwannoma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | Schwannoma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Tongue | | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X X X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | Schwannoma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | Schwannoma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Adenoma | X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + | Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + M + + + + + + + M M + + + + + M M M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + +| Hemangiosarcoma, Metastatic, Tongue | | Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| Schwannoma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + M +| Leukemia Mononuclear | X X X X X X X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| Mesothelioma Malignant | | Sarcoma | X | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M + M + + + + M + + + M + + + + + + M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X X X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + | Schwannoma Malignant, Metastatic, | | Mesentery | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X | Meninges, Granular Cell Tumor Benign | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Liposarcoma | X | Oncocytoma Benign | X | Renal Tubule, Adenoma | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | Polyp Adenomatous | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + | Mesothelioma Malignant | X X | Schwannoma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X | Mesothelioma Malignant | X | Schwannoma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Tongue | + | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Schwannoma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | Schwannoma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Interstitial Cell, Adenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + | Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M M + + M + + + + M + M + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Tongue | X | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Schwannoma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | X | Sarcoma | | __________________________________________________________________________| Thymus | + + + + + + + + M + M + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + + + + + + M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | | Schwannoma Malignant, Metastatic, | | Mesentery | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Leukemia Mononuclear | X X | Meninges, Granular Cell Tumor Benign | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Liposarcoma | | Oncocytoma Benign | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 49 | Leukemia Mononuclear | | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X | 29 | __________________________________________________________________________|____________| Mesentery | + | 16 | Mesothelioma Malignant | | 2 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Adenoma | | 2 | Leukemia Mononuclear | X | 7 | Mesothelioma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Leukemia Mononuclear | | 5 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Leukemia Mononuclear | | 5 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 9 | __________________________________________________________________________|____________| Heart | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X | 16 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X | 24 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Leukemia Mononuclear | X X | 20 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | | 13 | Bilateral, Pheochromocytoma Benign | X | 15 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Adenoma | | 6 | Carcinoma | X | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Leukemia Mononuclear | X X X | 22 | Pars Distalis, Adenoma | X X | 36 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | Leukemia Mononuclear | | 2 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Mesothelioma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Penis | | 4 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Prostate | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Leukemia Mononuclear | | 7 | Mesothelioma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Testes | + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X | 18 | Interstitial Cell, Adenoma | X X | 17 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | Leukemia Mononuclear | X X X X X | 27 | __________________________________________________________________________|____________| Lymph Node | + + + + | 20 | Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | X X | 4 | Pancreatic, Leukemia Mononuclear | X X X | 6 | Renal, Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M | 36 | Leukemia Mononuclear | X X X X | 22 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 48 | Hemangiosarcoma, Metastatic, Tongue | | 1 | Leukemia Mononuclear | X X X X | 22 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | Leukemia Mononuclear | X X X X | 25 | Schwannoma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + | 45 | Leukemia Mononuclear | X X X X | 24 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Leukemia Mononuclear | X X X X X | 29 | Mesothelioma Malignant | | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + | 46 | Leukemia Mononuclear | X X | 12 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + | 31 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Keratoacanthoma | | 4 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Schwannoma Malignant, Metastatic, | | | Mesentery | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | | 8 | Meninges, Granular Cell Tumor Benign | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | __________________________________________________________________________|____________| Lung | + + + + + | 50 | Alveolar/Bronchiolar Adenoma | | 2 | Leukemia Mononuclear | X X X X X | 29 | Osteosarcoma, Metastatic, Bone | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + | 50 | Leukemia Mononuclear | X | 18 | __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Leukemia Mononuclear | X X X X X | 25 | Liposarcoma | | 1 | Oncocytoma Benign | | 1 | Renal Tubule, Adenoma | | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X | 29 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + | Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Mesentery | + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | Thymoma Malignant, Metastatic, Thymus| X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Carcinoma, | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Metastatic, Lung | X | Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Bone | | Thymoma Malignant, Metastatic, Thymus| X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | Adenoma | X | Carcinoma | X X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + | Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Penis | + + | Leukemia Mononuclear | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + M + + + M + + + + | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | Adenoma | | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Mesothelioma Malignant | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + | Pancreatic, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + M + + M + + + M M + + M + + M + + M | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + M + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Thymus | + + + + + M M + + + + + + + + + M + + M + + + + | Leukemia Mononuclear | X X X X X | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M I + M M M M + + + + M + M + M M M + + M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + | Keratoacanthoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibroma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | Osteosarcoma | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + | Astrocytoma Benign | | Leukemia Mononuclear | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + A + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Thyroid Gland | X | Leukemia Mononuclear | X X X X X X X X X X | Osteosarcoma, Metastatic, Bone | | Thymoma Malignant, Metastatic, Thymus| X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Mesothelioma Malignant | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Pleura | + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Intestine Small, Duodenum | + A A + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | Thymoma Malignant, Metastatic, Thymus| | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Metastatic, Lung | | Leukemia Mononuclear | X X X X | Osteosarcoma, Metastatic, Bone | | Thymoma Malignant, Metastatic, Thymus| | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Penis | + + | Leukemia Mononuclear | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | Mesothelioma Malignant | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Mesothelioma Malignant | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + +| Pancreatic, Leukemia Mononuclear | X X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M M M + M + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + M| Leukemia Mononuclear | X X X X | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M M M + + M M M M M + M + M + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibroma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | + + | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| Astrocytoma Benign | | Leukemia Mononuclear | X X | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + A + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X X X X X | Osteosarcoma, Metastatic, Bone | | Thymoma Malignant, Metastatic, Thymus| | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinum, Mesothelioma Malignant | | __________________________________________________________________________| Nose | + A + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Pleura | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 48 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 47 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X X | 23 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 17 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Thymoma Malignant, Metastatic, Thymus| | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | | 3 | Mesothelioma Malignant | | 3 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Leukemia Mononuclear | X | 7 | Osteosarcoma, Metastatic, Bone | X | 1 | Thymoma Malignant, Metastatic, Thymus| | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 49 | Leukemia Mononuclear | X | 14 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 49 | Leukemia Mononuclear | X | 11 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X X | 11 | Bilateral, Pheochromocytoma Benign | | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Adenoma | X | 2 | Carcinoma | | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M + | 48 | Leukemia Mononuclear | X | 14 | Pars Distalis, Adenoma | X X | 30 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Adenoma | X X X | 8 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Mesothelioma Malignant | | 4 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Penis | | 4 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 48 | Carcinoma | X X | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Leukemia Mononuclear | X | 5 | Mesothelioma Malignant | | 2 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 4 | Bilateral, Interstitial Cell, Adenoma| X X X X X | 27 | Interstitial Cell, Adenoma | | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | X X | 19 | __________________________________________________________________________|____________| Lymph Node | + | 13 | Pancreatic, Leukemia Mononuclear | | 6 | Renal, Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + | 37 | Leukemia Mononuclear | X X | 15 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 47 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + | 48 | Leukemia Mononuclear | X X | 18 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Leukemia Mononuclear | X X X | 23 | Mesothelioma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Thymus | + + + + M M | 42 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 10 | Thymoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M M + M | 21 | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Keratoacanthoma | | 2 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 3 | Mesothelioma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Astrocytoma Benign | X | 1 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Leukemia Mononuclear | X X | 20 | Osteosarcoma, Metastatic, Bone | X | 1 | Thymoma Malignant, Metastatic, Thymus| | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinum, Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + | 49 | Leukemia Mononuclear | X | 17 | __________________________________________________________________________|____________| Pleura | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Leukemia Mononuclear | X | 18 | Mesothelioma Malignant | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Renal Tubule, Adenoma | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Leukemia Mononuclear | | 4 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Leukemia Mononuclear | X X X | 23 | Mesothelioma Malignant | | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | X | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + M + + + M + + M + + + + M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + + + M M + + M + + + + M M M + M + +| Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + I + + + + +| Keratoacanthoma | X X | Leukemia Mononuclear | X | Squamous Cell Carcinoma | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Melanoma Benign | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Histiocytic Sarcoma | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Renal Tubule, Adenoma | X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + A + A + + | Carcinoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + | Hepatocellular Adenoma | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Oral Mucosa | + + | Pharyngeal, Squamous Cell Carcinoma | | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | X X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | X | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | X X | Carcinoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | | Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + | Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X | Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + | Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + + + + + M M M M M M + + | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + + + | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + M + + + + + + + | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + M + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M M + + M M M M + M M + + + M M + M + + | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + | Keratoacanthoma | X X | Leukemia Mononuclear | | Squamous Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Melanoma Benign | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skeletal Muscle | + | Histiocytic Sarcoma | X | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + | Astrocytoma Malignant | X | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + I + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + A + + + + + + | Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 46 | Carcinoma | | 1 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Hepatocellular Adenoma | | 2 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 29 | __________________________________________________________________________|____________| Mesentery | | 7 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Oral Mucosa | + | 4 | Pharyngeal, Squamous Cell Carcinoma | X | 1 | Pharyngeal, Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Adenoma | | 2 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Leukemia Mononuclear | X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X | 20 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Leukemia Mononuclear | X X X | 15 | Pheochromocytoma Benign | X X X | 15 | Bilateral, Pheochromocytoma Benign | X | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Adenoma | X | 4 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Leukemia Mononuclear | X X | 17 | Pars Distalis, Adenoma | X X X X | 34 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Bilateral, C-Cell, Adenoma | | 1 | C-Cell, Adenoma | | 5 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 50 | Adenoma | | 1 | Carcinoma | | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Leukemia Mononuclear | X | 7 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X | 27 | Interstitial Cell, Adenoma | X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Leukemia Mononuclear | X X X | 23 | __________________________________________________________________________|____________| Lymph Node | + + | 13 | Iliac, Leukemia Mononuclear | X X | 2 | Pancreatic, Leukemia Mononuclear | X | 10 | Renal, Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M + | 36 | Leukemia Mononuclear | X X | 18 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 47 | Leukemia Mononuclear | X X X | 21 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | Leukemia Mononuclear | X X X | 24 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 47 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X | 22 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 29 | __________________________________________________________________________|____________| Thymus | + + M + + + | 46 | Leukemia Mononuclear | X X | 15 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M + + | 26 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + | 49 | Keratoacanthoma | | 4 | Leukemia Mononuclear | X | 2 | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Melanoma Benign | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 88034-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC 30-MONTH OZONE Date: 03/27/96 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:31:41 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | | 7 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | A + I + + + | 47 | __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X | 25 | __________________________________________________________________________|____________| Nose | + + + + + + | 49 | Leukemia Mononuclear | X X | 19 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Leukemia Mononuclear | X X X | 23 | Renal Tubule, Adenoma | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 49 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X | 29 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------