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TDMS Study 88034-05 Pathology Tables

NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  03/24/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X     X  X  X     X  X                    X     X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +  +                       +        +               |             
      Leukemia Mononuclear                 |    X                    X                                X               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |       +                                                                  |             
      Gingival, Squamous Cell Carcinoma    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X  X                                X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |    X        X  X        X  X     X                             X        X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X        X  X     X                             X         |             
      Pheochromocytoma Malignant           |                      X                                                   |             
      Pheochromocytoma Benign              |                      X           X  X                    X           X   |             
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Carcinoma                            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X        X  X  X        X                    X              X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |    X  X  X  X  X  X  X     X  X     X     X  X  X     X  X  X  X     X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                 X              X                  |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      C-Cell, Carcinoma                    |                                           X           X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  M  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X                                      X|             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |             X        X  X                                                |             
      Polyp Stromal                        |    X                                                                 X   |             
      Polyp Stromal, Multiple              |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X     X  X        X  X                    X     X        X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +        +  +                 +  +              +|             
      Deep Cervical, Leukemia Mononuclear  |                      X                                                   |             
      Iliac, Leukemia Mononuclear          |                      X  X                                                |             
      Pancreatic, Leukemia Mononuclear     |                         X        X  X                    X              X|             
      Renal, Leukemia Mononuclear          |                      X  X        X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +     M  M  M  +  M  +  +|             
      Leukemia Mononuclear                 |             X  X     X  X           X                          X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X        X  X        X  X                    X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X        X  X        X  X                    X     X        X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X  X        X                       X     X         |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X     X  X  X     X  X                    X     X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |    X        X        X  X        X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                X        X                             X           X      |             
      Carcinoma, Multiple                  |          X                                                               |             
      Fibroadenoma                         |                X                    X        X                           |             
      Fibroadenoma, Multiple               |                      X                                X              X   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Uterus                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                       X                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Glioma Benign                        |                         X                                                |             
      Leukemia Mononuclear                 |             X        X  X                                               X|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Mammary Gland |                                                                   X      |             
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |             
      Leukemia Mononuclear                 |    X        X  X     X  X  X     X  X                    X     X        X|             
      Squamous Cell Carcinoma              |                                                             X            |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X           X                                               X|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X        X        X  X  X     X  X                    X     X        X|             
      Renal Tubule, Carcinoma              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |    X                                                                     |             
      Leukemia Mononuclear                 |    X        X  X     X  X  X     X  X                    X     X        X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A  +  +  +  +  +  +  +  +     +  +  +  +  +  A     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A  +  +  +  +  +  +  +  +     +  +  +  +  +  A     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A  +  +  +  +  +  +  +  A     +  +  +  +  +  A     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X  X     X        X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +              +     +  +     +                     |             
      Leukemia Mononuclear                 |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
      Gingival, Squamous Cell Carcinoma    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                      X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Carcinoma                            |          X                 X                                             |             
      Leukemia Mononuclear                 |                   X     X           X  X  X              X               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X     X              X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                X                          X  X  X  X                     |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                      X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |       X  X  X  X  X  X  X  X        X  X  X  X  X  X     X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X              X                                         X      |             
      C-Cell, Adenoma, Multiple            |                                           X                              |             
      C-Cell, Carcinoma                    |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     I  +  +  M  +  +|             
      Adenoma                              |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                           X                 X            |             
      Polyp Stromal, Multiple              |                                                          X               |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X  X              X               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                       +                    +               |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                          X               |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       M  M  M  +  +  M  M  M  +     +  +  M  M  M  M     +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                   X                 X  X                 X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X  X  X              X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +  I  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X  X              X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +  +  +  M  +  +  +  M  +     +  +  +  M  +  +     +  M  M  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X  X              X               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X  X     X        X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  I  M  +  +  +     +  M  +  +  +  +     +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                     X     X              X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |             X                                                        X   |             
      Carcinoma, Multiple                  |                                                                          |             
      Fibroadenoma                         |          X     X                          X        X                     |             
      Fibroadenoma, Multiple               |       X     X           X              X        X        X              X|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Keratoacanthoma                      |                                           X                              |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Uterus                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                          X               |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Glioma Benign                        |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +  +  +  +  +  +  A     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Carcinoma, Metastatic, Mammary Gland |                                                                          |             
      Carcinoma, Metastatic, Adrenal Cortex|                            X                                             |             
      Leukemia Mononuclear                 |                   X     X           X  X  X              X        X      |             
      Squamous Cell Carcinoma              |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X     X           X     X              X               |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                   X     X           X  X  X     X        X        X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |  11        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Squamous Cell Carcinoma    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X        X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |                X                                                         |         15 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |         13 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X        X                                                               |         12 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  49        |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |         11 |
      Pars Distalis, Adenoma               | X  X  X  X  X  X                                                         |         44 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Adenoma                      |                                                                          |          6 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      C-Cell, Carcinoma                    |       X                                                                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  45        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  50        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |          4 |
      Polyp Stromal                        |                X                                                         |          5 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
      Schwannoma Malignant                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  10        |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  M  +  +                                                         |  27        |
      Leukemia Mononuclear                 |                X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |       X        X                                                         |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +                                                         |  47        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X        X                                                         |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  42        |
      Leukemia Mononuclear                 |       X        X                                                         |         14 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |         21 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  44        |
      Leukemia Mononuclear                 |       X        X                                                         |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
      Carcinoma                            |          X                                                               |          7 |
      Carcinoma, Multiple                  |                                                                          |          1 |
      Fibroadenoma                         |    X           X                                                         |          9 |
      Fibroadenoma, Multiple               |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  49        |
      Keratoacanthoma                      |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Uterus                          |             X                                                            |          1 |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Glioma Benign                        |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Mammary Gland |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X                                                         |         20 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X                                                         |         17 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          4 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X                                                         |         21 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X     X     X  X        X  X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                             +           +     +   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             
      Pharyngeal, Squamous Cell Papilloma  |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |          X                                   X                    X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |       X                                      X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X                 X                 X                    X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Adenoma                              |                         X                                                |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X              X                    X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X              X                    X      |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |       X  X        X           X     X                 X              X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Carcinoma                            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |       X  X                                   X                    X      |             
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X           X     X  X  X  X   |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
      C-Cell, Adenoma                      |          X           X                                                   |             
      C-Cell, Carcinoma                    |                                  X        X                              |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                         X                                                |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Granulosa Cell Tumor Benign          |                   X                                                      |             
      Leukemia Mononuclear                 |       X                                      X                    X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                            X                                             |             
      Polyp Stromal                        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X                 X              X  X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +        +     +                                      +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |             X              X                                      X      |             
      Renal, Leukemia Mononuclear          |                      X                                            X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X  X        X     X  X              X           X        X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +     +  +  A  M  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X     X  X              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X              X                    X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     M  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X           X        X              X           X        X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X     X     X  X        X  X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +     +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |       X  X           X                       X                    X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Carcinoma                            |       X  X        X  X                                                   |             
      Fibroadenoma                         |    X  X  X        X     X  X        X                 X        X     X   |             
      Fibroadenoma, Multiple               |             X        X        X        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X     X     X  X           X        X      |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Leukemia Mononuclear                 |       X  X                          X     X  X                    X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          A           +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
      Adenoma                              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X     X     X  X                    X      |             
      Renal Tubule, Adenoma                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +   |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |       X  X                                   X                           |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X        X     X  X     X     X  X        X  X        X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Polyp Adenomatous                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
      Leukemia Mononuclear                 |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
      Leukemia Mononuclear                 |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X        X  X  X           X  X                             X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +           +              +|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
      Pharyngeal, Squamous Cell Papilloma  |                               X                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Leukemia Mononuclear                 |                         X  X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X              X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X  X              X                             X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |             X        X  X  X           X  X                             X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |             X        X     X           X  X                             X|             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |             X        X     X        X                    X        X     X|             
      Bilateral, Pheochromocytoma Benign   |                                              X                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +     +  +  +  +     +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Carcinoma                            |                                                                   X      |             
      Leukemia Mononuclear                 |                         X  X              X                             X|             
      Pars Distalis, Adenoma               | X  X     X  X  X     X  X     X  X  X  X  X  X     X     X  X  X         |             
      Pars Intermedia, Adenoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                      X        X        X     X                           |             
      C-Cell, Carcinoma                    | X                                                                        |             
      Follicular Cell, Carcinoma           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Adenoma                              |    X                             X                          X            |             
      Carcinoma                            |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                            X           X                                X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                            X                                            X|             
      Polyp Stromal                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |             X           X  X           X  X                             X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +  +              +                             +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Deep Cervical, Leukemia Mononuclear  |                            X                                             |             
      Iliac, Leukemia Mononuclear          |                                           X                              |             
      Inguinal, Leukemia Mononuclear       |                                           X                              |             
      Pancreatic, Leukemia Mononuclear     |                            X              X                             X|             
      Renal, Leukemia Mononuclear          |          X              X  X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  M     +  +  +  +  +  +  M  +  M  +  M     +  +  M  +     +|             
      Leukemia Mononuclear                 |          X  X           X  X              X                             X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +     M  +  +  +     +|             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X           X  X              X                             X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X           X  X              X                             X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  M  +     +|             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X           X  X              X                             X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X        X  X  X           X  X                             X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X  X              X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Carcinoma                            |                                           X                              |             
      Fibroadenoma                         | X  X        X           X  X           X     X                           |             
      Fibroadenoma, Multiple               |                X              X                          X  X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                   X      |             
      Leukemia Mononuclear                 |                            X                                            X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  I  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                   X      |             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X        X  X  X           X  X                             X|             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                   X      |             
      Mediastinum, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Leukemia Mononuclear                 |             X           X  X              X                             X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                   X      |             
      Leukemia Mononuclear                 |             X        X  X  X           X  X                             X|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
      Leukemia Mononuclear                 |             X              X              X                              |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Histiocytic Sarcoma                  |       X                                                                  |             
      Leukemia Mononuclear                 |          X  X        X  X  X           X  X                             X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +                                                         |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +                                                         |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +                                                         |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +                                                         |  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  22                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X                                                               |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +  +                                                         |  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         17 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |          X  X                                                            |         16 |
      Pheochromocytoma Complex             |                X                                                         |          1 |
      Pheochromocytoma Benign              |                                                                          |         14 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +                                                         |  49        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +                                                         |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +                                                         |  49        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          9 |
      Pars Distalis, Adenoma               | X     X        X                                                         |         40 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +                                                         |  49        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          6 |
      C-Cell, Carcinoma                    |                                                                          |          3 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +                                                         |  48        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +                                                         |  50        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          7 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Polyp Stromal                        |          X     X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +                                                         |  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |  12        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |          X                                                               |          7 |
      Renal, Leukemia Mononuclear          |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +  +  +  +                                                         |  42        |
      Leukemia Mononuclear                 |          X                                                               |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  +                                                         |  44        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         16 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     M  +  +  +                                                         |  45        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         22 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |          X  X                                                            |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +                                                         |  50        |
      Carcinoma                            |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma                         | X                                                                        |         18 |
      Fibroadenoma, Multiple               |             X  X                                                         |         10 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +                                                         |  50        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +                                                         |  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         21 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Leukemia Mononuclear    |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |          X                                                               |         12 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X                                                               |         18 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +                                                         |  49        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                                               |          7 |
      Transitional Epithelium, Carcinoma   |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X                                                            |         22 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  26                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X  X     X     X        X  X                    X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                    +         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                    X                       X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
      Squamous Cell Carcinoma              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                      X                       X  X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Leukemia Mononuclear                 | X  X              X     X              X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                                   X  X                    X  X      |             
      Pheochromocytoma Malignant           |                                                                   X      |             
      Pheochromocytoma Benign              |       X  X        X              X        X                       X      |             
      Bilateral, Pheochromocytoma Benign   |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +     +  +  M  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                             X                          X      |             
      Pars Distalis, Adenoma               |       X  X  X  X  X     X     X  X  X     X  X  X     X     X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |          X                       X                                       |             
      C-Cell, Carcinoma                    |       X                                   X              X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenoma                              |       X     X                                               X            |             
      Carcinoma                            |                               X                       X           X      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                          X      |             
      Polyp Stromal                        | X                                      X  X                              |             
      Sarcoma Stromal                      |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X                    X  X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +                             +                          +      |             
      Pancreatic, Leukemia Mononuclear     | X  X                                   X                          X      |             
      Renal, Leukemia Mononuclear          |          X                             X                          X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  M  M  M  M  +     +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X                             X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X                    X                       X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X                    X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X     X                             X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X  X     X     X        X  X                    X  X  X   |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X              X              X                       X  X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma, Multiple                    |                                                                          |             
      Carcinoma                            |             X                             X  X                           |             
      Fibroadenoma                         |       X  X     X     X           X  X        X     X  X  X           X   |             
      Fibroadenoma, Multiple               |                               X                             X  X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                X                    X                                    |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                             X            |             
      Carcinoma, Metastatic, Thyroid Gland |       X                                                                  |             
      Leukemia Mononuclear                 | X  X     X     X  X     X     X        X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chondroma                            |                                                                          |             
      Leukemia Mononuclear                 |                   X                       X                       X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X                    X  X                    X  X      |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X  X     X     X        X  X                    X  X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +  I  +  +     +  +  +  I  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     A  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X        X     X     X        X                    X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                            +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X           X                    X                                       |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                    X                                       |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                      X     X     X  X                          X         |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +     +  +  +  +     +  +  +  M  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X                              |             
      Pars Distalis, Adenoma               | X           X     X     X              X  X  X  X  X  X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                         X                                                |             
      C-Cell, Carcinoma                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +     +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +|             
      Adenoma                              |             X                                               X  X         |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                             X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |    X                    X                 X                              |             
      Sarcoma Stromal                      |                                                             X            |             
      Schwannoma Malignant                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X        X     X     X        X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                    +                                       |             
      Pancreatic, Leukemia Mononuclear     |             X                    X                                       |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +     +  +  M  +     +  M  M  M  +  +  M  M     +  M  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     M  +     +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X           X        X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     M  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X     X        X                    X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     M  +     +  +  +  +     M  +  +  +  +  +  +  +     M  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X              X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X        X     X     X        X                    X         |             
      Sarcoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Adenoma, Multiple                    | X                                                                        |             
      Carcinoma                            |                   X                                         X  X         |             
      Fibroadenoma                         | X  X              X  X           X           X  X     X                  |             
      Fibroadenoma, Multiple               |                                     X  X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Osteoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                X         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                X         |             
      Leukemia Mononuclear                 | X           X        X     X     X        X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Chondroma                            |                                        X                                 |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                    X                              |             
      Renal Tubule, Adenoma                |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X        X     X     X        X                    X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         20 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |         12 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         10 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |          X                                                               |         12 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +                                                         |  50        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M  +  +  +                                                         |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          7 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  33                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |    X  X  X  X  X                                                         |         37 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +                                                         |  50        |
      Bilateral, C-Cell, Adenoma           |                X                                                         |          1 |
      C-Cell, Adenoma                      |                                                                          |          3 |
      C-Cell, Carcinoma                    |                                                                          |          4 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M  +  +  +  +                                                         |  47        |
      Adenoma                              |                                                                          |          6 |
      Carcinoma                            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |                                                                          |          6 |
      Sarcoma Stromal                      |                                                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                                                               |   9        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          6 |
      Renal, Leukemia Mononuclear          |    X                                                                     |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +  M  +  +                                                         |  34        |
      Leukemia Mononuclear                 |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  M  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |    X                                                                     |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +  +  +  +                                                         |  45        |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         20 |
      Sarcoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +                                                         |  48        |
      Leukemia Mononuclear                 |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +                                                         |  50        |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma                            |             X                                                            |          7 |
      Fibroadenoma                         |          X                                                               |         20 |
      Fibroadenoma, Multiple               |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +                                                         |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Melanoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +                                                         |  50        |
      Osteoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  +  +                                                         |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          2 |
      Leukemia Mononuclear                 |    X                                                                     |         18 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +                                                         |  50        |
      Chondroma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         12 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         20 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Adenomatous                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 | X  X     X     X     X     X  X  X     X           X  X     X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +  +  +           +  +  +                 +  +   |             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                   X                                                      |             
      Leukemia Mononuclear                 | X              X                                      X     X            |             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                           X            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                      X              X     X            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X                       X              X                  |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +     +  +  +                 +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X     X           X     X              X     X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                    X        X  X     X           X  X     X     X     X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                    X        X  X     X           X  X     X     X      |             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |       X  X              X        X     X                    X        X   |             
      Bilateral, Pheochromocytoma Benign   |                X           X  X     X        X  X     X           X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              | X                 X                                X                     |             
      Carcinoma                            |    X     X                                X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X     X     X  X  X     X           X  X     X           X|             
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X        X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      C-Cell, Adenoma                      | X                                X                                       |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                              X                           |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X                                                     X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X                                      X     X            |             
      Mesothelioma Malignant               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                                                        |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                               X        X        X     X           X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |       X  X  X  X           X              X  X                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X        X     X     X     X  X  X     X           X  X     X           X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +           +     +  +  +        +  +     +     +  +   |             
      Leukemia Mononuclear                 |                                                       X                  |             
      Iliac, Leukemia Mononuclear          |                                                             X            |             
      Pancreatic, Leukemia Mononuclear     |                                        X                    X            |             
      Renal, Leukemia Mononuclear          |                               X                    X  X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +     M  M  M|             
      Leukemia Mononuclear                 | X              X           X  X  X     X           X  X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Hemangiosarcoma, Metastatic, Tongue  |                                                                          |             
      Leukemia Mononuclear                 | X  X           X     X     X  X  X                 X  X     X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X  X           X     X     X  X  X     X           X  X     X           X|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  M  +|             
      Leukemia Mononuclear                 | X              X     X     X  X  X     X           X  X     X           X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X     X     X  X  X     X           X  X     X     X     X|             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                    X        X        X           X  X     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +     +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Keratoacanthoma                      | X        X     X                       X                                 |             
      Leukemia Mononuclear                 | X                                                     X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Astrocytoma Malignant                |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                             X  X     X              X     X            |             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Leukemia Mononuclear                 | X  X     X     X     X     X  X  X     X           X  X     X     X     X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X           X  X  X     X           X  X     X            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X              X     X     X  X  X     X           X  X     X           X|             
      Liposarcoma                          |          X                                                               |             
      Oncocytoma Benign                    |                                           X                              |             
      Renal Tubule, Adenoma                |          X              X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X                                X                    X     X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X     X     X  X  X     X           X  X     X     X     X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                   +  +  +     +           +      |             
      Mesothelioma Malignant               |                                                 X                 X      |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                   X                                                      |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
      Mesothelioma Malignant               |                                                 X                        |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
      Hemangiosarcoma                      | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                             +              +                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |          X  X                    X              X                    X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X     X        X        X           X   |             
      Pheochromocytoma Malignant           |    X                                                                     |             
      Pheochromocytoma Benign              |    X  X  X        X                 X        X                           |             
      Bilateral, Pheochromocytoma Benign   |             X              X     X        X        X  X                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              | X  X                 X                                                   |             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |          X  X              X     X     X  X     X                    X   |             
      Pars Distalis, Adenoma               |    X     X  X     X  X              X  X     X        X  X  X        X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      C-Cell, Adenoma                      |                   X              X                                       |             
      C-Cell, Carcinoma                    |                            X                                             |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mesothelioma Malignant               |                                                 X                        |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                 +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                            X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                  X              X                    X   |             
      Mesothelioma Malignant               |                                                                   X      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                 X                        |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X                    X        X     X  X     X        X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |          X        X  X     X           X     X        X              X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +  +                    +              +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                          X               |             
      Pancreatic, Leukemia Mononuclear     |             X                                                            |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +     M  M     +     +  M  +  +  +  +  M  +  M  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemangiosarcoma, Metastatic, Tongue  | X                                                                        |             
      Leukemia Mononuclear                 |    X                             X     X  X     X        X           X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X                    X     X  X     X        X           X   |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +     M  +     +     +  +  +  +  +  +  +  +  +  M     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X                    X     X  X     X        X           X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
      Mesothelioma Malignant               |                                                                   X      |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +     +     M  +  M  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                 X        X           X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +  M     +     +  +  +  +  +  M  +  M  M  M     M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Mesentery                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X                                               X               |             
      Meninges, Granular Cell Tumor Benign |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                                                            |             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X        X     X        X               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X        X              X     X     X  X     X        X           X   |             
      Liposarcoma                          |                                                                          |             
      Oncocytoma Benign                    |                                                                          |             
      Renal Tubule, Adenoma                |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |    X     X  X              X     X     X  X     X        X           X   |             
      Mesothelioma Malignant               |                                                 X                 X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Adenomatous                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +                                                         |  50        |
      Hepatocellular Adenoma               |    X                                                                     |          1 |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         29 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  16        |
      Mesothelioma Malignant               |                                                                          |          2 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +                                                         |  50        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |          X                                                               |          7 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hemangiosarcoma                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  45                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X  X  X  X                                                               |         16 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +     +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X     X                                                         |         24 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |    X           X                                                         |         20 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |                                                                          |         13 |
      Bilateral, Pheochromocytoma Benign   |                X                                                         |         15 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +                                                         |  50        |
      Adenoma                              |                                                                          |          6 |
      Carcinoma                            |          X                                                               |          5 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |    X  X  X                                                               |         22 |
      Pars Distalis, Adenoma               | X              X                                                         |         36 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |                X                                                         |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +                                                         |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  46                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|                X                                                         |         18 |
      Interstitial Cell, Adenoma           |    X  X                                                                  |         17 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         27 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +                                                         |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |    X           X                                                         |          4 |
      Pancreatic, Leukemia Mononuclear     | X        X     X                                                         |          6 |
      Renal, Leukemia Mononuclear          | X        X     X                                                         |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     M                                                         |  36        |
      Leukemia Mononuclear                 | X  X  X  X                                                               |         22 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +                                                         |  48        |
      Hemangiosarcoma, Metastatic, Tongue  |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X  X                                                               |         22 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +                                                         |  49        |
      Leukemia Mononuclear                 | X  X     X     X                                                         |         25 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +     +                                                         |  45        |
      Leukemia Mononuclear                 |    X  X  X     X                                                         |         24 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         29 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +                                                         |  46        |
      Leukemia Mononuclear                 | X              X                                                         |         12 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +     +                                                         |  31        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +                                                         |  50        |
      Keratoacanthoma                      |                                                                          |          4 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +                                                         |  50        |
      Osteosarcoma                         |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +                                                         |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
      Meninges, Granular Cell Tumor Benign |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         29 |
      Osteosarcoma, Metastatic, Bone       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |         18 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         25 |
      Liposarcoma                          |                                                                          |          1 |
      Oncocytoma Benign                    |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +                                                         |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          6 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X  X  X  X     X                                                         |         29 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  49                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +   |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X  X  X     X         |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +     +  +           +                          +     +     +  +  +   |             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X              X               |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                   +              +                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |             X                                                            |             
      Leukemia Mononuclear                 |                                           X              X               |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                          X     X  X  X        X           X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                               X     X  X  X        X           X         |             
      Pheochromocytoma Malignant           |    X                                                                     |             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |    X                 X  X     X           X        X                     |             
      Bilateral, Pheochromocytoma Benign   | X                                   X                    X     X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                   X                                                      |             
      Carcinoma                            | X                                         X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                          X     X     X        X     X               |             
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X  X  X  X     X     X           X  X  X  X        X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                          +               |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 +        +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +   |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                    X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                          X               |             
      Mesothelioma Malignant               |                                                          X               |             
      Bilateral, Interstitial Cell, Adenoma|    X     X                 X  X           X     X  X        X  X         |             
      Interstitial Cell, Adenoma           |                   X  X              X                    X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                    X     X  X  X        X     X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +              +     +                       +         |             
      Pancreatic, Leukemia Mononuclear     |    X                                   X                       X         |             
      Renal, Leukemia Mononuclear          |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  +  M  +  +  +  M  M  +  +  M  +  +  M  +  +  M   |             
      Leukemia Mononuclear                 |    X     X                    X     X                    X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +   |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X     X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |          X                    X     X  X  X        X     X     X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                    X     X  X  X        X     X     X         |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X  X  X     X         |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +   |             
      Leukemia Mononuclear                 |          X                    X     X              X           X         |             
      Thymoma Malignant                    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  I  +  M  M  M  M  +  +  +  +  M  +  M  +  M  M  M  +  +  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Keratoacanthoma                      |                      X                                                   |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Astrocytoma Benign                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Carcinoma, Metastatic, Thyroid Gland |                   X                                                      |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X     X     X         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                   X      |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |             X                                                            |             
      Mediastinum, Mesothelioma Malignant  |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X     X     X         |             
                                            __________________________________________________________________________|             
   Pleura                                  |             +                                                            |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                 +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X     X     X         |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Renal Tubule, Adenoma                |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                     X                    X               |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  53                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X     X                 X  X     X  X  X        X  X  X     X         |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hepatocellular Adenoma               |                                                             X            |             
      Leukemia Mononuclear                 |       X  X                    X        X  X     X     X  X  X            |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                 +        +        +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
      Thymoma Malignant, Metastatic, Thymus|                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |          X                    X                                          |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  M  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |          X                                                  X            |             
      Mesothelioma Malignant               |                               X                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
      Leukemia Mononuclear                 |          X                    X                       X     X            |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X                 X     X     X            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                                      X           X            |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Complex             |                            X                                             |             
      Pheochromocytoma Benign              |                X  X                             X                        |             
      Bilateral, Pheochromocytoma Benign   | X                                      X                    X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X     X            |             
      Pars Distalis, Adenoma               | X           X  X           X     X     X           X     X  X     X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      C-Cell, Adenoma                      | X                                X                       X  X            |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mesothelioma Malignant               |                      X        X                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                                  +            |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |          X                                                  X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                      X        X                          X               |             
      Bilateral, Interstitial Cell, Adenoma|          X  X  X  X              X     X  X     X     X  X  X     X     X|             
      Interstitial Cell, Adenoma           |       X                       X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X  X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +                             +  +     +                       +|             
      Pancreatic, Leukemia Mononuclear     |       X  X                                      X                        |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  +     M  +  +     +  +     +  +  +  +  +     M     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  M  +     +     +|             
      Leukemia Mononuclear                 |       X  X                                X     X     X     X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X  X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X     X            |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X        X  X     X     X  X  X            |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     M  +  +  +  +     +     M|             
      Leukemia Mononuclear                 |       X  X                                            X     X            |             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  +  +     M  M  M     M  M     +  M  +  M  +     +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Keratoacanthoma                      |                                                             X            |             
      Squamous Cell Papilloma              |                                                             X            |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +           +                                          |             
      Mesothelioma Malignant               |                               X                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Astrocytoma Benign                   |                                                                          |             
      Leukemia Mononuclear                 |       X  X                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X               |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X  X  X            |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Mesothelioma Malignant  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X                  |             
                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X           X     X     X     X            |             
      Mesothelioma Malignant               |                                                          X               |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                   X                                                      |             
      Renal Tubule, Adenoma                |                X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |          X                                                  X            |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Leukemia Mononuclear                 |       X  X                    X        X  X     X     X  X  X            |             
      Mesothelioma Malignant               |                      X        X                          X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  59                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  48        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X                                                                  |         23 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                                                         |  17        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Thymoma Malignant, Metastatic, Thymus|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          3 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          7 |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
      Thymoma Malignant, Metastatic, Thymus|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X                                                                  |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X                                                                  |         11 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |    X  X                                                                  |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |             X                                                            |          2 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +                                                         |  48        |
      Leukemia Mononuclear                 |       X                                                                  |         14 |
      Pars Distalis, Adenoma               |    X     X                                                               |         30 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Adenoma                      |    X  X        X                                                         |          8 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Mesothelioma Malignant               |                                                                          |          4 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  61                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  48        |
      Carcinoma                            | X     X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          4 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X                                                         |         27 |
      Interstitial Cell, Adenoma           |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 | X     X                                                                  |         19 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |  13        |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          6 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  37        |
      Leukemia Mononuclear                 | X     X                                                                  |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 | X     X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 | X     X                                                                  |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +                                                         |  48        |
      Leukemia Mononuclear                 | X     X                                                                  |         18 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         23 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M                                                         |  42        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  62                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X                                                                  |         10 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  M                                                         |  21        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Osteosarcoma                         |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          2 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Astrocytoma Benign                   |       X                                                                  |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |          3 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X                                                                  |         20 |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
      Thymoma Malignant, Metastatic, Thymus|                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Mesothelioma Malignant  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  63                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |     A      |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X                                                                  |         17 |
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X                                                                  |         18 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 | X  X  X                                                                  |         23 |
      Mesothelioma Malignant               |                                                                          |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  64                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +  +     +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                       X        X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X        X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X     X  X     X        X        X     X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                    +        +         |             
      Leukemia Mononuclear                 |                                  X                    X        X         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
      Pharyngeal, Squamous Cell Carcinoma  |                                                                          |             
      Pharyngeal, Squamous Cell Papilloma  |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                   X                                   X        X  X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                                   X        X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X        X         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                          +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                   X              X              X     X     X  X  X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X              X              X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  65                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                   X              X                    X        X  X      |             
      Pheochromocytoma Benign              |    X           X           X     X        X                          X   |             
      Bilateral, Pheochromocytoma Benign   |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X              X              X     X     X  X  X  X   |             
      Pars Distalis, Adenoma               |    X     X     X        X  X  X  X  X  X  X  X     X     X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Bilateral, C-Cell, Adenoma           |                            X                                             |             
      C-Cell, Adenoma                      |                         X     X        X                                 |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                            X                                             |             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                   X           X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                            X                                             |             
      Bilateral, Interstitial Cell, Adenoma|          X     X  X        X                    X     X     X  X  X  X  X|             
      Interstitial Cell, Adenoma           |                         X        X        X  X     X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X     X  X              X        X     X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                   +        +  +      |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                   X                                   X           X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  66                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                   X                                   X        X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +     +  +     +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  M|             
      Leukemia Mononuclear                 |          X     X  X              X                    X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                X  X              X              X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X  X              X        X     X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X     X  X              X              X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X     X  X     X        X        X     X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X              X              X     X     X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M     +  +     +  M  M  +  +  M  +  +  +  +  M  M  M  +  M  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Keratoacanthoma                      |                   X                                X                     |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Melanoma Benign |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                   X              X                    X        X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X     X  X              X        X     X     X     X  X  X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X              X        X     X     X     X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  67                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X     X  X              X        X     X     X     X  X  X  X   |             
      Renal Tubule, Adenoma                |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                            X  X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X     X  X     X        X        X     X     X     X  X  X  X   |             
      Mesothelioma Malignant               |                            X                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  68                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  A  +     +      |             
      Carcinoma                            |                                                       X                  |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X  X                 X  X  X  X  X  X  X           X     X     X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +           +     +                 +            |             
      Leukemia Mononuclear                 |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             | +                                                                 +      |             
      Pharyngeal, Squamous Cell Carcinoma  |                                                                          |             
      Pharyngeal, Squamous Cell Papilloma  | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                               X                    X                     |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                         +                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X                    X  X        X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |    X                    X  X  X     X                       X     X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  69                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X                    X  X  X     X                       X     X      |             
      Pheochromocytoma Benign              |                      X           X  X        X  X     X                  |             
      Bilateral, Pheochromocytoma Benign   | X           X                             X                 X     X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                            X                          X                  |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |    X                       X        X     X                 X     X      |             
      Pars Distalis, Adenoma               | X     X  X  X  X  X  X  X  X  X           X  X  X     X  X  X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                      X                    X                              |             
      Follicular Cell, Carcinoma           |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                                           X                              |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Adenoma                              |                                                 X                        |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X  X                                      X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X              X           X     X  X  X  X  X  X  X        X     X      |             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |    X                    X  X        X  X  X                 X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                       +     +     +              +     +     +      |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |    X                       X     X                    X     X     X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  70                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Leukemia Mononuclear          |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  M  M  +     +      |             
      Leukemia Mononuclear                 |    X                    X  X        X  X                    X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +      |             
      Leukemia Mononuclear                 |    X                    X  X        X  X  X           X     X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +      |             
      Leukemia Mononuclear                 |       X                 X  X  X     X  X  X           X     X     X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +      |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X                    X  X     X  X  X              X     X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X  X                 X  X  X  X  X  X  X           X     X     X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +     +      |             
      Leukemia Mononuclear                 |                         X  X                                X     X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  M  M  M  M  +  M  M  +  +  +  M  M  +  M  +     +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Keratoacanthoma                      |                X           X                                             |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                           X                              |             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
      Subcutaneous Tissue, Melanoma Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Astrocytoma Malignant                |                X                                                         |             
      Leukemia Mononuclear                 |                         X           X                       X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X                    X  X  X     X  X  X           X     X     X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |    X                    X  X        X  X  X                 X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  71                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +        +                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |    X                    X  X        X  X  X                 X     X      |             
      Renal Tubule, Adenoma                |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +     +      |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Histiocytic Sarcoma                  |                                                    X                     |             
      Leukemia Mononuclear                 |    X  X                 X  X  X  X  X  X  X           X     X     X      |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  72                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  46        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X     X                                                         |         29 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   4        |
      Pharyngeal, Squamous Cell Carcinoma  |    X                                                                     |          1 |
      Pharyngeal, Squamous Cell Papilloma  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          7 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          6 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                X                                                         |          5 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         11 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  73                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         20 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         15 |
      Pheochromocytoma Benign              |    X  X        X                                                         |         15 |
      Bilateral, Pheochromocytoma Benign   |          X                                                               |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |       X                                                                  |          4 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |          X     X                                                         |         17 |
      Pars Distalis, Adenoma               | X        X  X  X                                                         |         34 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          5 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          7 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  74                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X  X     X                                                         |         27 |
      Interstitial Cell, Adenoma           | X                                                                        |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         23 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +                                                               |  13        |
      Iliac, Leukemia Mononuclear          |       X  X                                                               |          2 |
      Pancreatic, Leukemia Mononuclear     |       X                                                                  |         10 |
      Renal, Leukemia Mononuclear          |       X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  +                                                         |  36        |
      Leukemia Mononuclear                 |       X        X                                                         |         18 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  47        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         24 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  47        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         22 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X     X                                                         |         29 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +                                                         |  46        |
      Leukemia Mononuclear                 |          X     X                                                         |         15 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  +  +                                                         |  26        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  49        |
      Keratoacanthoma                      |                                                                          |          4 |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Melanoma Benign |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  75                                                               
NTP Experiment-Test: 88034-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 03/27/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:31:41  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0|                                                        |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |     A      |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |     L      |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | A  +  I  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X     X                                                         |         25 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |       X        X                                                         |         19 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
      Carcinoma                            |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Leukemia Mononuclear                 |       X  X     X                                                         |         23 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  49        |
      Leukemia Mononuclear                 |                X                                                         |          5 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +                                                         |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X  X     X                                                         |         29 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  76                                                               
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                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------