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TDMS Study 88034-05 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               OZONE


NTP Experiment-Test: 88034-05                                                                                     Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                                                                      Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  03/24/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56                                                  
  Scheduled Sacrifice                                  6            6            6                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36           37           40                                                  
    Natural Death                                      8            7            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            6            7                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (50)                                                
   Intestine Large, Rectum                            (48)         (50)         (47)                                                
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Cecum                             (48)         (49)         (50)                                                
   Intestine Small, Duodenum                          (47)         (49)         (49)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Intestine Small, Jejunum                           (47)         (47)         (49)                                                
   Intestine Small, Ileum                             (46)         (47)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Mesentery                                          (11)         (7)          (4)                                                 
   Oral Mucosa                                        (2)          (2)                                                              
      Gingival, Squamous Cell Carcinoma                1 (50%)                                                                      
      Pharyngeal, Squamous Cell Papilloma                           2 (100%)                                                        
   Pancreas                                           (49)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
   Stomach, Forestomach                               (49)         (50)         (50)                                                
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Tongue                                                          (1)          (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma                                        2 (4%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (50)                                                
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)                                             
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         12 (24%)     14 (29%)     12 (24%)                                            
      Bilateral, Pheochromocytoma Benign               1 (2%)       1 (2%)       2 (4%)                                             
   Islets, Pancreatic                                 (49)         (49)         (50)                                                
      Carcinoma                                        2 (4%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (44)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
      Pars Distalis, Adenoma                          44 (88%)     40 (82%)     37 (74%)                                            
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  6 (12%)      6 (12%)      3 (6%)                                             
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                4 (8%)       3 (6%)       4 (8%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (48)         (47)                                                
      Adenoma                                          3 (7%)       3 (6%)       6 (13%)                                            
      Carcinoma                                                     2 (4%)       3 (6%)                                             
   Ovary                                              (50)         (50)         (50)                                                
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
      Polyp Stromal                                    5 (10%)      3 (6%)       6 (12%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                                            1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (10)         (12)         (9)                                                 
   Lymph Node, Bronchial                              (27)         (42)         (34)                                                
   Lymph Node, Mandibular                             (47)         (44)         (46)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (47)         (50)         (49)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mediastinal                            (42)         (45)         (45)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (44)         (47)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)                                                
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        7 (14%)      5 (10%)      7 (14%)                                            
      Carcinoma, Multiple                              1 (2%)                                                                       
      Fibroadenoma                                     9 (18%)     18 (36%)     20 (40%)                                            
      Fibroadenoma, Multiple                          10 (20%)     10 (20%)      5 (10%)                                            
   Skin                                               (49)         (50)         (50)                                                
      Keratoacanthoma                                  1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Uterus         1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Malignant                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Glioma Benign                                    1 (2%)                                                                       
   Spinal Cord                                        (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (47)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                                       2 (4%)                                             
      Carcinoma, Metastatic, Adrenal Cortex            1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)       1 (2%)                                                          
   Nose                                               (50)         (49)         (50)                                                
      Chondroma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
                                                             Page   5                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Leukemia Mononuclear                            21 (42%)     22 (44%)     20 (40%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          50                                                   
     Total Primary Neoplasms                          143         146         145                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          45          48                                                   
     Total Benign Neoplasms                            96         106         101                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          31          32                                                   
     Total Malignant Neoplasms                         47          40          44                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           2                                                   
     Total Metastatic Neoplasm                          4           9           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          56           56           56                                                  
  Scheduled Sacrifice                                  6            6            6                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                47           43           42                                                  
    Natural Death                                      3            7            7                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                                           1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (49)                                                
      Polyp Adenomatous                                1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Intestine Large, Cecum                             (49)         (50)         (49)                                                
   Intestine Small, Duodenum                          (50)         (48)         (49)                                                
   Intestine Small, Jejunum                           (50)         (46)         (46)                                                
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (49)         (47)         (48)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Mesentery                                          (16)         (17)         (7)                                                 
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (6%)                                                          
      Schwannoma Malignant                             1 (6%)                                                                       
      Thymoma Malignant, Metastatic, Thymus                         1 (6%)                                                          
   Oral Mucosa                                                                  (4)                                                 
      Pharyngeal, Squamous Cell Carcinoma                                        1 (25%)                                            
      Pharyngeal, Squamous Cell Papilloma                                        2 (50%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Adenoma                                          2 (4%)                    2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Mesentery      1 (2%)                                                                       
   Salivary Glands                                    (50)         (49)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Tongue                                             (1)                                                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
                                                             Page   8                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Thymoma Malignant, Metastatic, Thymus                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (49)         (50)                                                
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)                                                          
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         13 (26%)     11 (22%)     15 (30%)                                            
      Bilateral, Pheochromocytoma Benign              15 (30%)      7 (14%)      8 (16%)                                            
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          6 (12%)      2 (4%)       4 (8%)                                             
      Carcinoma                                        5 (10%)      2 (4%)       1 (2%)                                             
   Parathyroid Gland                                  (49)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (48)         (50)                                                
      Pars Distalis, Adenoma                          36 (72%)     30 (63%)     34 (68%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  5 (10%)      8 (16%)      5 (10%)                                            
      C-Cell, Carcinoma                                1 (2%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Mesentery      1 (2%)                                                                       
   Penis                                              (4)          (4)          (1)                                                 
   Preputial Gland                                    (50)         (48)         (50)                                                
                                                             Page   9                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                     3 (6%)       2 (4%)                                             
   Prostate                                           (50)         (50)         (50)                                                
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)                                                
      Schwannoma Malignant, Metastatic, Mesentery      1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           18 (36%)     27 (54%)     27 (54%)                                            
      Interstitial Cell, Adenoma                      17 (34%)      6 (12%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (20)         (13)         (13)                                                
   Lymph Node, Bronchial                              (36)         (37)         (36)                                                
   Lymph Node, Mandibular                             (48)         (47)         (47)                                                
      Hemangiosarcoma, Metastatic, Tongue              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (49)         (49)                                                
      Schwannoma Malignant, Metastatic, Mesentery      1 (2%)                                                                       
   Lymph Node, Mediastinal                            (45)         (48)         (47)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Thymus                                             (46)         (42)         (46)                                                
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (31)         (21)         (26)                                                
   Skin                                               (50)         (50)         (49)                                                
      Keratoacanthoma                                  4 (8%)       2 (4%)       4 (8%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                  1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Benign                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Osteosarcoma                                     1 (2%)       1 (2%)                                                          
   Skeletal Muscle                                    (1)          (3)          (2)                                                 
      Histiocytic Sarcoma                                                        1 (50%)                                            
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (33%)                                                         
      Schwannoma Malignant, Metastatic, Mesentery      1 (100%)                                                                     
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Benign                                            1 (2%)                                                          
      Astrocytoma Malignant                            1 (2%)                    1 (2%)                                             
      Meninges, Granular Cell Tumor Benign             1 (2%)                                                                       
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (48)         (47)                                                
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Thymoma Malignant, Metastatic, Thymus                         1 (2%)                                                          
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)                                                          
   Nose                                               (50)         (49)         (49)                                                
   Pleura                                                          (1)                                                              
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Liposarcoma                                      1 (2%)                                                                       
      Oncocytoma Benign                                1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
                                                             Page  11                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
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         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
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URINARY SYSTEM - cont                                                                                                               
      Renal Tubule, Adenoma                            3 (6%)       2 (4%)       2 (4%)                                             
   Urinary Bladder                                    (50)         (50)         (49)                                                
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            29 (58%)     23 (46%)     29 (58%)                                            
      Mesothelioma Malignant                           2 (4%)       4 (8%)       1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 88034-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:42:15  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.5 PPM      1.0 PPM                                                
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          48          49                                                   
     Total Primary Neoplasms                          174         142         158                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          46          48                                                   
     Total Benign Neoplasms                           128         104         118                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          30          33                                                   
     Total Malignant Neoplasms                         46          38          40                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5                                                               
     Total Metastatic Neoplasm                          7          20                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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