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TDMS Study 88034-05 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 05                                                                                     TIME: 21:56:11       
TEST TYPE:  CHRONIC 30-MONTH                    CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 05                                                                                     TIME: 21:56:11       
TEST TYPE:  CHRONIC 30-MONTH                    CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                          OZONE                                         DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 05                                                                                     TIME: 21:56:11       
TEST TYPE:  CHRONIC 30-MONTH                    CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95239          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 10028-15-6      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                            IN THE ANALYSIS OF THE STUDY OF 6  OZONE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Islets, Pancreatic            Carcinoma
                                            Carcinoma or Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              All Organs                    Benign Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Clitoral/Preputial Gland      Carcinoma or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              All Organs                    Benign Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/49 (0%)       0/50 (0%)      |     2/50 (4%)       0/49 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     10.6%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      566             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.071N        P=0.158N        P=0.199N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.109N        P=0.263N        P=0.258N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.104N        P=0.260N        P=0.244N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.096N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.253N        P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    28/50 (56%)     18/49 (37%)     23/50 (46%)     |    13/50 (26%)     15/49 (31%)     14/50 (28%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     81.2%           67.5%           78.5%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     4/6 (67%)       2/6 (33%)       4/7 (57%)      |
|FIRST INCIDENCE (DAYS) |      580             601             383           |      577             585             536           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.010N**      P=0.176N        P=0.023N*      |     P=0.396N        P=0.332N        P=0.428N       |
|INCIDENTAL TUMOR       |     P=0.080N        P=0.139N        P=0.110N       |     P=0.543         P=0.506         P=0.583        |
|LOGISTIC REGRESSION    |     P=0.039N*       P=0.095N        P=0.078N       |     P=0.478N        P=0.489N        P=0.502N       |
|COCHRAN-ARMITAGE       |     P=0.183N                                       |     P=0.456                                        |
|FISHER EXACT           |                     P=0.042N*       P=0.212N       |                     P=0.387         P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/49 (2%)       0/50 (0%)      |     1/50 (2%)       0/49 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     21.4%            5.3%            0.0%          |     16.7%            0.0%           14.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      691             650             ---           |      874 (T)         ---             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.072N        P=0.545N        P=0.094N       |     P=0.636N        P=0.500N        P=0.735N       |
|INCIDENTAL TUMOR       |     P=0.130N        P=0.564N        P=0.212N       |     P=0.636N        P=0.500N        P=0.735N       |
|LOGISTIC REGRESSION    |     P=0.119N        P=0.557N        P=0.185N       |     P=0.636N        P=0.500N        P=0.735N       |
|COCHRAN-ARMITAGE       |     P=0.143N                                       |     P=0.668                                        |
|FISHER EXACT           |                     P=0.508N        P=0.247N       |                     P=0.505N        P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    28/50 (56%)     19/49 (39%)     23/50 (46%)     |    13/50 (26%)     16/49 (33%)     14/50 (28%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     81.2%           75.6%           78.5%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     4/6 (67%)       3/6 (50%)       4/7 (57%)      |
|FIRST INCIDENCE (DAYS) |      580             495             383           |      577             585             536           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.010N*       P=0.223N        P=0.023N*      |     P=0.391N        P=0.409N        P=0.428N       |
|INCIDENTAL TUMOR       |     P=0.084N        P=0.194N        P=0.110N       |     P=0.544N        P=0.414         P=0.583        |
|LOGISTIC REGRESSION    |     P=0.045N*       P=0.157N        P=0.078N       |     P=0.469N        P=0.553N        P=0.502N       |
|COCHRAN-ARMITAGE       |     P=0.184N                                       |     P=0.456                                        |
|FISHER EXACT           |                     P=0.065N        P=0.212N       |                     P=0.306         P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/48 (0%)       1/50 (2%)      |     3/45 (7%)       3/48 (6%)       6/47 (13%)     |
|ADJUSTED (b)           |      2.6%            0.0%           14.3%          |     13.8%           21.4%           41.8%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        1/6 (17%)       1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      583             ---             760           |      635             513             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.622N        P=0.552N        P=0.733N       |     P=0.254         P=0.526N        P=0.366        |
|INCIDENTAL TUMOR       |     P=0.649         P=0.550N        P=0.746        |     P=0.225         P=0.628N        P=0.309        |
|LOGISTIC REGRESSION    |     P=0.642N        P=0.482N        P=0.749N       |     P=0.227         P=0.628N        P=0.344        |
|COCHRAN-ARMITAGE       |     P=0.668                                        |     P=0.193                                        |
|FISHER EXACT           |                     P=0.510N        P=0.753N       |                     P=0.630N        P=0.265        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       3/48 (6%)       2/50 (4%)      |     0/45 (0%)       2/48 (4%)       3/47 (6%)      |
|ADJUSTED (b)           |      0.0%           20.8%           19.2%          |      0.0%            8.0%           21.4%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      ---             411             751           |      ---             756             670           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.374         P=0.098         P=0.400        |     P=0.109         P=0.407         P=0.167        |
|INCIDENTAL TUMOR       |     P=0.209         P=0.153         P=0.264        |     P=0.106         P=0.300         P=0.158        |
|LOGISTIC REGRESSION    |     P=0.206         P=0.149         P=0.342        |     P=0.099         P=0.300         P=0.157        |
|COCHRAN-ARMITAGE       |     P=0.203                                        |     P=0.086                                        |
|FISHER EXACT           |                     P=0.114         P=0.247        |                     P=0.264         P=0.129        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       3/48 (6%)       3/50 (6%)      |     3/45 (7%)       5/48 (10%)      9/47 (19%)     |
|ADJUSTED (b)           |      2.6%           20.8%           30.7%          |     13.8%           27.7%           55.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        1/6 (17%)       2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      583             411             751           |      635             513             670           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.413         P=0.247         P=0.456        |     P=0.083         P=0.576         P=0.140        |
|INCIDENTAL TUMOR       |     P=0.242         P=0.333         P=0.314        |     P=0.064         P=0.425         P=0.098        |
|LOGISTIC REGRESSION    |     P=0.251         P=0.369         P=0.393        |     P=0.062         P=0.426         P=0.112        |
|COCHRAN-ARMITAGE       |     P=0.240                                        |     P=0.047 *                                      |
|FISHER EXACT           |                     P=0.293         P=0.309        |                     P=0.394         P=0.070        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      2/50 (4%)       4/50 (8%)      |     0/49 (0%)       0/49 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     26.6%           10.2%           17.9%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      468             623             653           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.165N        P=0.178N        P=0.206N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.289N        P=0.179N        P=0.358N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.275N        P=0.145N        P=0.368N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.290N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.134N        P=0.370N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      2/50 (4%)       1/50 (2%)      |     2/49 (4%)       1/49 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     58.1%           37.8%            3.6%          |     16.5%           16.7%            6.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        1/6 (17%)       0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      580             674             650           |      718             874 (T)         775           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.038N*       P=0.355N        P=0.072N       |     P=0.318N        P=0.402N        P=0.426N       |
|INCIDENTAL TUMOR       |     P=0.068N        P=0.310N        P=0.119N       |     P=0.340N        P=0.459N        P=0.462N       |
|LOGISTIC REGRESSION    |     P=0.049N*       P=0.274N        P=0.098N       |     P=0.317N        P=0.371N        P=0.446N       |
|COCHRAN-ARMITAGE       |     P=0.060N                                       |     P=0.372N                                       |
|FISHER EXACT           |                     P=0.218N        P=0.102N       |                     P=0.500N        P=0.492N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)      4/50 (8%)       5/50 (10%)     |     2/49 (4%)       1/49 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     69.2%           44.1%           20.9%          |     16.5%           16.7%            6.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        1/6 (17%)       0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      468             623             650           |      718             874 (T)         775           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.022N*       P=0.116N        P=0.036N*      |     P=0.318N        P=0.402N        P=0.426N       |
|INCIDENTAL TUMOR       |     P=0.056N        P=0.089N        P=0.091N       |     P=0.340N        P=0.459N        P=0.462N       |
|LOGISTIC REGRESSION    |     P=0.043N*       P=0.067N        P=0.083N       |     P=0.317N        P=0.371N        P=0.446N       |
|COCHRAN-ARMITAGE       |     P=0.053N                                       |     P=0.372N                                       |
|FISHER EXACT           |                     P=0.045N*       P=0.086N       |                     P=0.500N        P=0.492N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       2/50 (4%)       2/50 (4%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     14.5%           25.0%           55.6%          |      0.0%            5.3%           14.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      580             719             756           |      ---             803             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.200N        P=0.533N        P=0.336N       |     P=0.376         P=0.672         P=0.531        |
|INCIDENTAL TUMOR       |     P=0.402N        P=0.595N        P=0.513N       |     P=0.360         P=0.535         P=0.531        |
|LOGISTIC REGRESSION    |     P=0.301N        P=0.563N        P=0.418N       |     P=0.372         P=0.571         P=0.531        |
|COCHRAN-ARMITAGE       |     P=0.406N                                       |     P=0.331                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       2/50 (4%)       2/50 (4%)      |     1/50 (2%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     14.5%           25.0%           55.6%          |     16.7%            5.3%           14.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      580             719             756           |      874 (T)         803             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.200N        P=0.533N        P=0.336N       |     P=0.586N        P=0.669N        P=0.735N       |
|INCIDENTAL TUMOR       |     P=0.402N        P=0.595N        P=0.513N       |     P=0.602N        P=0.741N        P=0.735N       |
|LOGISTIC REGRESSION    |     P=0.301N        P=0.563N        P=0.418N       |     P=0.579N        P=0.665N        P=0.735N       |
|COCHRAN-ARMITAGE       |     P=0.406N                                       |     P=0.640                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.753N        P=0.753N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.2%           25.0%           17.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      521             735             643           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.530         P=0.716         P=0.560        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.370         P=0.730N        P=0.469        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.408         P=0.755         P=0.499        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.378                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.753N        P=0.500        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       3/50 (6%)       0/50 (0%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     25.9%           22.3%            0.0%          |      0.0%            3.0%            3.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      708             581             ---           |      ---             710             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.075N        P=0.475         P=0.085N       |     P=0.351         P=0.581         P=0.529        |
|INCIDENTAL TUMOR       |     P=0.197N        P=0.411         P=0.212N       |     P=0.351         P=0.535         P=0.522        |
|LOGISTIC REGRESSION    |     P=0.161N        P=0.427         P=0.169N       |     P=0.330         P=0.507         P=0.500        |
|COCHRAN-ARMITAGE       |     P=0.202N                                       |     P=0.331                                        |
|FISHER EXACT           |                     P=0.500         P=0.247N       |                     P=0.500         P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       4/50 (8%)       0/50 (0%)      |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     25.9%           26.2%            0.0%          |     12.5%            8.7%            3.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      708             581             ---           |      827             710             685           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.091N        P=0.307         P=0.085N       |     P=0.564N        P=0.684         P=0.719N       |
|INCIDENTAL TUMOR       |     P=0.210N        P=0.250         P=0.212N       |     P=0.591N        P=0.562         P=0.738N       |
|LOGISTIC REGRESSION    |     P=0.182N        P=0.266         P=0.169N       |     P=0.594N        P=0.598         P=0.738N       |
|COCHRAN-ARMITAGE       |     P=0.222N                                       |     P=0.622N                                       |
|FISHER EXACT           |                     P=0.339         P=0.247N       |                     P=0.500         P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     8/50 (16%)      5/50 (10%)      7/50 (14%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     43.4%           44.4%           45.7%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     2/6 (33%)       2/6 (33%)       2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      417             571             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.334N        P=0.193N        P=0.385N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.451N        P=0.322N        P=0.520N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.422N        P=0.270N        P=0.498N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.442N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.277N        P=0.500N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     8/50 (16%)      5/50 (10%)      8/50 (16%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     43.4%           44.4%           47.2%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     2/6 (33%)       2/6 (33%)       2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      417             571             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.444N        P=0.193N        P=0.485N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.536         P=0.322N        P=0.574        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.543N        P=0.270N        P=0.605        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.557                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.277N        P=0.607N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |    19/50 (38%)     28/50 (56%)     25/50 (50%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     93.1%          100.0%           79.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     5/6 (83%)       6/6 (100%)      2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      557             579             580           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.450         P=0.528         P=0.481        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.203         P=0.087         P=0.227        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.234         P=0.288         P=0.250        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.135                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.054         P=0.157        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |    19/50 (38%)     28/50 (56%)     25/50 (50%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     93.1%          100.0%           79.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     5/6 (83%)       6/6 (100%)      2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      557             579             580           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.450         P=0.528         P=0.481        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.203         P=0.087         P=0.227        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.234         P=0.288         P=0.250        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.135                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.054         P=0.157        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |    24/50 (48%)     29/50 (58%)     30/50 (60%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     93.9%          100.0%           89.9%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     5/6 (83%)       6/6 (100%)      4/7 (57%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      417             571             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.478         P=0.337N        P=0.521        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.192         P=0.296         P=0.218        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.229         P=0.478         P=0.251        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.134                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.212         P=0.158        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%          100.0%          |      0.0%           19.9%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     0/6 (0%)        1/6 (17%)       0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             666           |      ---             756             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.317           (e)           P=0.555        |     P=0.628N        P=0.314           (e)          |
|INCIDENTAL TUMOR       |     P=0.294           (e)           P=0.523        |     P=0.640N        P=0.259           (e)          |
|LOGISTIC REGRESSION    |     P=0.178           (e)           P=0.366        |     P=0.635N        P=0.325           (e)          |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.669                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       3/50 (6%)      |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%          100.0%          |      4.8%           19.9%            2.8%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     0/6 (0%)        1/6 (17%)       0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             619           |      719             756             663           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.127           (e)           P=0.285        |     P=0.565N        P=0.626         P=0.722N       |
|INCIDENTAL TUMOR       |     P=0.096           (e)           P=0.224        |     P=0.585N        P=0.541         P=0.738N       |
|LOGISTIC REGRESSION    |     P=0.064           (e)           P=0.167        |     P=0.596N        P=0.599         P=0.762N       |
|COCHRAN-ARMITAGE       |     P=0.037 *                                      |     P=0.622N                                       |
|FISHER EXACT           |                       (e)           P=0.121        |                     P=0.500         P=0.753N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       2/50 (4%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%          100.0%          |      0.0%           19.9%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     0/6 (0%)        1/6 (17%)       0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      ---             ---             666           |      ---             756             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.317           (e)           P=0.555        |     P=0.628N        P=0.314           (e)          |
|INCIDENTAL TUMOR       |     P=0.294           (e)           P=0.523        |     P=0.640N        P=0.259           (e)          |
|LOGISTIC REGRESSION    |     P=0.178           (e)           P=0.366        |     P=0.635N        P=0.325           (e)          |
|COCHRAN-ARMITAGE       |     P=0.095                                        |     P=0.669                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.247           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       2/50 (4%)      |     0/49 (0%)       0/49 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     13.5%            0.0%           10.8%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      674             ---             708           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.381N        P=0.247N        P=0.438N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.579N        P=0.278N        P=0.654N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.547N        P=0.270N        P=0.634N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.247N        P=0.691N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    36/50 (72%)     30/48 (63%)     34/50 (68%)     |    44/50 (88%)     40/49 (82%)     37/50 (74%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%           97.4%          100.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     6/6 (100%)      5/6 (83%)       7/7 (100%)     |
|FIRST INCIDENCE (DAYS) |      467             346             383           |      406             513             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.048N*       P=0.464N        P=0.068N       |     P=0.047N*       P=0.022N*       P=0.061N       |
|INCIDENTAL TUMOR       |     P=0.346N        P=0.350N        P=0.402N       |     P=0.033N*       P=0.197N        P=0.053N       |
|LOGISTIC REGRESSION    |     P=0.336N        P=0.316N        P=0.385N       |     P=0.016N*       P=0.074N        P=0.025N*      |
|COCHRAN-ARMITAGE       |     P=0.374N                                       |     P=0.048N*                                      |
|FISHER EXACT           |                     P=0.216N        P=0.414N       |                     P=0.274N        P=0.062N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    36/50 (72%)     30/48 (63%)     34/50 (68%)     |    44/50 (88%)     41/49 (84%)     37/50 (74%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%           97.6%          100.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     6/6 (100%)      5/6 (83%)       7/7 (100%)     |
|FIRST INCIDENCE (DAYS) |      467             346             383           |      406             513             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.048N*       P=0.464N        P=0.068N       |     P=0.046N*       P=0.028N*       P=0.061N       |
|INCIDENTAL TUMOR       |     P=0.346N        P=0.350N        P=0.402N       |     P=0.031N*       P=0.275N        P=0.053N       |
|LOGISTIC REGRESSION    |     P=0.336N        P=0.316N        P=0.385N       |     P=0.014N*       P=0.112N        P=0.025N*      |
|COCHRAN-ARMITAGE       |     P=0.374N                                       |     P=0.046N*                                      |
|FISHER EXACT           |                     P=0.216N        P=0.414N       |                     P=0.371N        P=0.062N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       2/50 (4%)       5/50 (10%)     |     3/50 (6%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |     24.7%           28.4%           59.8%          |     24.3%            0.0%           28.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      610             636             632           |      691             ---             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.385N        P=0.416N        P=0.449N       |     P=0.333N        P=0.080N        P=0.428N       |
|INCIDENTAL TUMOR       |     P=0.418         P=0.441N        P=0.497        |     P=0.339N        P=0.103N        P=0.436N       |
|LOGISTIC REGRESSION    |     P=0.538         P=0.401N        P=0.604        |     P=0.316N        P=0.081N        P=0.401N       |
|COCHRAN-ARMITAGE       |     P=0.424                                        |     P=0.390N                                       |
|FISHER EXACT           |                     P=0.339N        P=0.500        |                     P=0.121N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |     1/50 (2%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            8.9%            7.7%          |      5.0%           16.7%           16.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        1/6 (17%)       1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      ---             628             741           |      722             874 (T)         643           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.500         P=0.212         P=0.690        |     P=0.420         P=0.713N        P=0.545        |
|INCIDENTAL TUMOR       |     P=0.330         P=0.183         P=0.523        |     P=0.388         P=0.741N        P=0.497        |
|LOGISTIC REGRESSION    |     P=0.391         P=0.221         P=0.584        |     P=0.417         P=0.689N        P=0.535        |
|COCHRAN-ARMITAGE       |     P=0.360                                        |     P=0.378                                        |
|FISHER EXACT           |                     P=0.247         P=0.500        |                     P=0.753N        P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  15
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |     2/50 (4%)       2/50 (4%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            8.9%            7.7%          |     20.8%           18.5%           20.8%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       1/6 (17%)       1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      ---             628             741           |      722             513             643           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.500         P=0.212         P=0.690        |     P=0.464         P=0.653N        P=0.570        |
|INCIDENTAL TUMOR       |     P=0.330         P=0.183         P=0.523        |     P=0.415         P=0.692         P=0.522        |
|LOGISTIC REGRESSION    |     P=0.391         P=0.221         P=0.584        |     P=0.441         P=0.645N        P=0.567        |
|COCHRAN-ARMITAGE       |     P=0.360                                        |     P=0.406                                        |
|FISHER EXACT           |                     P=0.247         P=0.500        |                     P=0.691N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       2/50 (4%)       4/50 (8%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     24.7%           28.4%           19.6%          |      5.6%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      610             636             632           |      731             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.277N        P=0.416N        P=0.351N       |     P=0.230N        P=0.398N        P=0.460N       |
|INCIDENTAL TUMOR       |     P=0.563         P=0.441N        P=0.633        |     P=0.252N        P=0.465N        P=0.478N       |
|LOGISTIC REGRESSION    |     P=0.502N        P=0.401N        P=0.591N       |     P=0.259N        P=0.480N        P=0.485N       |
|COCHRAN-ARMITAGE       |     P=0.579                                        |     P=0.269N                                       |
|FISHER EXACT           |                     P=0.339N        P=0.643N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  16
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       2/50 (4%)       5/50 (10%)     |     3/50 (6%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |     24.7%           28.4%           59.8%          |     24.3%            0.0%           28.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      610             636             632           |      691             ---             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.385N        P=0.416N        P=0.449N       |     P=0.333N        P=0.080N        P=0.428N       |
|INCIDENTAL TUMOR       |     P=0.418         P=0.441N        P=0.497        |     P=0.339N        P=0.103N        P=0.436N       |
|LOGISTIC REGRESSION    |     P=0.538         P=0.401N        P=0.604        |     P=0.316N        P=0.081N        P=0.401N       |
|COCHRAN-ARMITAGE       |     P=0.424                                        |     P=0.390N                                       |
|FISHER EXACT           |                     P=0.339N        P=0.500        |                     P=0.121N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       2/50 (4%)       4/50 (8%)      |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     24.7%           28.4%           19.6%          |     21.3%            0.0%           14.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      610             636             632           |      731             ---             874 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.277N        P=0.416N        P=0.351N       |     P=0.313N        P=0.185N        P=0.440N       |
|INCIDENTAL TUMOR       |     P=0.563         P=0.441N        P=0.633        |     P=0.322N        P=0.220N        P=0.451N       |
|LOGISTIC REGRESSION    |     P=0.502N        P=0.401N        P=0.591N       |     P=0.292N        P=0.160N        P=0.414N       |
|COCHRAN-ARMITAGE       |     P=0.579                                        |     P=0.360N                                       |
|FISHER EXACT           |                     P=0.339N        P=0.643N       |                     P=0.247N        P=0.500N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  17
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    35/50 (70%)     33/50 (66%)     33/50 (66%)     |                                                    |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |                                                    |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |                                                    |
|FIRST INCIDENCE (DAYS) |      468             411             419           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.030N*       P=0.410         P=0.045N*      |                                                    |
|INCIDENTAL TUMOR       |     P=0.309N        P=0.446         P=0.332N       |                                                    |
|LOGISTIC REGRESSION    |     P=0.265N        P=0.382         P=0.283N       |                                                    |
|COCHRAN-ARMITAGE       |     P=0.375N                                       |                                                    |
|FISHER EXACT           |                     P=0.415N        P=0.415N       |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      8/50 (16%)      6/50 (12%)     |     7/50 (14%)      6/49 (12%)      4/50 (8%)      |
|ADJUSTED (b)           |     50.8%           54.5%           59.0%          |     56.9%           40.0%           26.5%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     2/6 (33%)       1/6 (17%)       1/7 (14%)      |
|FIRST INCIDENCE (DAYS) |      610             531             383           |      696             723             566           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.403N        P=0.187         P=0.565N       |     P=0.127N        P=0.226N        P=0.173N       |
|INCIDENTAL TUMOR       |     P=0.432         P=0.186         P=0.480        |     P=0.179N        P=0.395N        P=0.234N       |
|LOGISTIC REGRESSION    |     P=0.470         P=0.188         P=0.502        |     P=0.138N        P=0.234N        P=0.185N       |
|COCHRAN-ARMITAGE       |     P=0.440                                        |     P=0.216N                                       |
|FISHER EXACT           |                     P=0.277         P=0.500        |                     P=0.516N        P=0.262N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  18
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       0/50 (0%)      |     4/50 (8%)       3/49 (6%)       4/50 (8%)      |
|ADJUSTED (b)           |      2.6%            4.2%            0.0%          |     32.8%           16.0%           40.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     1/6 (17%)       0/6 (0%)        2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |      583             623             ---           |      678             767             744           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.335N        P=0.718         P=0.516N       |     P=0.447N        P=0.237N        P=0.521N       |
|INCIDENTAL TUMOR       |     P=0.389N        P=0.707         P=0.550N       |     P=0.510N        P=0.418N        P=0.574N       |
|LOGISTIC REGRESSION    |     P=0.333N        P=0.759N        P=0.498N       |     P=0.478N        P=0.349N        P=0.528N       |
|COCHRAN-ARMITAGE       |     P=0.331N                                       |     P=0.576                                        |
|FISHER EXACT           |                     P=0.753N        P=0.500N       |                     P=0.511N        P=0.643N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      9/50 (18%)      6/50 (12%)     |    10/50 (20%)      9/49 (18%)      8/50 (16%)     |
|ADJUSTED (b)           |     52.1%           56.4%           59.0%          |     65.3%           49.6%           59.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     2/6 (33%)       1/6 (17%)       3/7 (43%)      |
|FIRST INCIDENCE (DAYS) |      583             531             383           |      678             723             566           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.311N        P=0.191         P=0.450N       |     P=0.193N        P=0.144N        P=0.242N       |
|INCIDENTAL TUMOR       |     P=0.528         P=0.182         P=0.587        |     P=0.271N        P=0.354N        P=0.326N       |
|LOGISTIC REGRESSION    |     P=0.533N        P=0.200         P=0.617        |     P=0.213N        P=0.130N        P=0.253N       |
|COCHRAN-ARMITAGE       |     P=0.557                                        |     P=0.348N                                       |
|FISHER EXACT           |                     P=0.288         P=0.620N       |                     P=0.520N        P=0.398N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  19
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       1/50 (2%)      |     0/50 (0%)       1/49 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     53.1%            0.0%            5.3%          |      0.0%            4.3%            5.3%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      674             ---             708           |      ---             775             753           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.235N        P=0.322N        P=0.330N       |     P=0.387         P=0.647         P=0.576        |
|INCIDENTAL TUMOR       |     P=0.332N        P=0.278N        P=0.459N       |     P=0.351         P=0.535         P=0.522        |
|LOGISTIC REGRESSION    |     P=0.264N        P=0.272N        P=0.385N       |     P=0.350         P=0.550         P=0.523        |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P=0.332                                        |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.495         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     6/50 (12%)      3/50 (6%)       6/50 (12%)     |
|ADJUSTED (b)           |                                                    |     29.5%           23.8%           37.1%          |
|TERMINAL (d)           |                                                    |     0/6 (0%)        1/6 (17%)       2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      556             616             486           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.478N        P=0.105N        P=0.518N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.559N        P=0.229N        P=0.603N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.548N        P=0.200N        P=0.602N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.566                                        |
|FISHER EXACT           |                                                    |                     P=0.243N        P=0.620N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  20
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     6/50 (12%)      3/50 (6%)       7/50 (14%)     |
|ADJUSTED (b)           |                                                    |     29.5%           23.8%           42.8%          |
|TERMINAL (d)           |                                                    |     0/6 (0%)        1/6 (17%)       2/7 (29%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      556             616             486           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.532         P=0.105N        P=0.610N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.447         P=0.229N        P=0.523        |
|LOGISTIC REGRESSION    |                                                    |     P=0.462         P=0.200N        P=0.533        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.436                                        |
|FISHER EXACT           |                                                    |                     P=0.243N        P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    29/50 (58%)     23/50 (46%)     29/50 (58%)     |    21/50 (42%)     22/50 (44%)     20/50 (40%)     |
|ADJUSTED (b)           |    100.0%          100.0%           92.7%          |     74.9%           80.1%           85.6%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     2/6 (33%)       3/6 (50%)       5/7 (71%)      |
|FIRST INCIDENCE (DAYS) |      481             411             419           |      467             452             486           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.123N        P=0.404N        P=0.174N       |     P=0.256N        P=0.239N        P=0.284N       |
|INCIDENTAL TUMOR       |     P=0.446         P=0.321N        P=0.473        |     P=0.449N        P=0.512         P=0.477N       |
|LOGISTIC REGRESSION    |     P=0.462         P=0.287N        P=0.453        |     P=0.408N        P=0.566         P=0.427N       |
|COCHRAN-ARMITAGE       |     P=0.540                                        |     P=0.460N                                       |
|FISHER EXACT           |                     P=0.158N        P=0.580N       |                     P=0.500         P=0.500N       |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  21
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       4/50 (8%)       1/50 (2%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      5.6%           13.6%           10.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     0/6 (0%)        0/6 (0%)        0/7 (0%)       |
|FIRST INCIDENCE (DAYS) |      539             433             754           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.346N        P=0.264         P=0.407N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.452N        P=0.337         P=0.531N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.414N        P=0.435         P=0.504N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.406N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.339         P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    49/50 (98%)     46/50 (92%)     48/50 (96%)     |    47/50 (94%)     45/50 (90%)     48/50 (96%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%          100.0%          100.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     6/6 (100%)      6/6 (100%)      7/7 (100%)     |
|FIRST INCIDENCE (DAYS) |      467             346             383           |      406             513             467           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.045N*       P=0.379         P=0.066N       |     P=0.230N        P=0.035N*       P=0.249N       |
|INCIDENTAL TUMOR       |     P=0.501N        P=0.583N        P=0.707N       |     P=0.469         P=0.230N        P=0.546        |
|LOGISTIC REGRESSION    |     P=0.588N        P=0.689         P=0.632N       |     P=0.525N        P=0.084N        P=0.705N       |
|COCHRAN-ARMITAGE       |     P=0.406N                                       |     P=0.421                                        |
|FISHER EXACT           |                     P=0.181N        P=0.500N       |                     P=0.357N        P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  22
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         0.5 PPM         1.0 PPM       |      CONTROL         0.5 PPM         1.0 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    35/50 (70%)     31/50 (62%)     33/50 (66%)     |    34/50 (68%)     31/50 (62%)     32/50 (64%)     |
|ADJUSTED (b)           |    100.0%          100.0%           94.7%          |     93.1%           95.2%           96.0%          |
|TERMINAL (d)           |     0/0             0/0             0/1 (0%)       |     4/6 (67%)       5/6 (83%)       6/7 (86%)      |
|FIRST INCIDENCE (DAYS) |      468             345             419           |      417             452             285           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.062N        P=0.517         P=0.090N       |     P=0.168N        P=0.054N        P=0.187N       |
|INCIDENTAL TUMOR       |     P=0.454N        P=0.364N        P=0.542N       |     P=0.359N        P=0.338N        P=0.404N       |
|LOGISTIC REGRESSION    |     P=0.323N        P=0.387N        P=0.371N       |     P=0.313N        P=0.238N        P=0.342N       |
|COCHRAN-ARMITAGE       |     P=0.376N                                       |     P=0.377N                                       |
|FISHER EXACT           |                     P=0.263N        P=0.415N       |                     P=0.338N        P=0.417N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    50/50 (100%)    48/50 (96%)     49/50 (98%)     |    49/50 (98%)     48/50 (96%)     50/50 (100%)    |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%          100.0%          100.0%          |
|TERMINAL (d)           |     0/0             0/0             1/1 (100%)     |     6/6 (100%)      6/6 (100%)      7/7 (100%)     |
|FIRST INCIDENCE (DAYS) |      467             345             383           |      406             452             285           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.048N*       P=0.334         P=0.070N       |     P=0.232N        P=0.047N*       P=0.251N       |
|INCIDENTAL TUMOR       |     P=0.484N        P=0.597N          (e)          |     P=0.358         P=0.455N        P=0.500        |
|LOGISTIC REGRESSION    |     P=0.623N        P=0.990N          (e)          |     P=0.605         P=0.242N        P=0.500        |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |     P=0.360                                        |
|FISHER EXACT           |                     P=0.247N        P=0.500N       |                     P=0.500N        P=0.500        |
|=================================================================================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 05                                                 PAGE  23
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 6  OZONE
                                                 TERMINAL SACRIFICE AT 125 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).