TDMS Study 88034-05 Pathology Tables
NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 Facility: Battelle Northwest Chemical CAS #: 10028-15-6 Lock Date: 03/24/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Adenomatous | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X X X X X | Clear Cell Focus | | Degeneration, Fatty | 2 2 2 3 3 3 2 3 3 2| Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X X X X X | Necrosis | | Thrombosis | 2 | Vacuolization Cytoplasmic, Focal | | Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 1 2 | Centrilobular, Necrosis | 3 1 2 2 3 | __________________________________________________________________________| Mesentery | + + + + + | Inflammation, Chronic Active | 3 | Artery, Mineralization | | Fat, Necrosis | 3 2 3 | __________________________________________________________________________| Oral Mucosa | + | Gingival, Cyst | | __________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 1 2 1 2 | Basophilic Focus | X | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 2 | Mineralization | | Necrosis | 3 3 1 3 4 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | Necrosis | 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 2 1 2 3 1 1 1 1 2 1 2| Artery, Mineralization | | Atrium, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 2 2 2 2 2 1 | Hypertrophy | 3 2 3| Necrosis | 2 | Thrombosis | | Vacuolization Cytoplasmic | 1 2 3 3 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 3 2 4 | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Pars Distalis, Hyperplasia | 3 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 1 2 2 1 1 1 2 2 1 1 2 1 1 1 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + M + +| Inflammation, Chronic Active | 4 3 3 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Lymph Node | + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Hemorrhage | | Renal, Inflammation, Granulomatous | 3 | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + M + + + + M + + + + + M M M + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 2 3 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + M + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 1 1 2 | Hematopoietic Cell Proliferation | | Thrombosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + M + +| Cyst | 1 | Hyperkeratosis | 3 | Inflammation, Chronic Active | 3 1 4 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Fracture | X| Hyperostosis | 4 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 2 | Mineralization | | Necrosis | | Thrombosis | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 | Epiglottis, Metaplasia, Squamous | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | | Alveolar Epithelium, Hyperplasia | 1 | Artery, Infiltration Cellular, | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5| DAY ON TEST | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8| | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Histiocyte | 3 | Artery, Mediastinum, Mineralization | | Artery, Perivascular, Inflammation, | | Chronic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | Thrombosis | 2 3 4 2| Lateral Wall, Hyperplasia | 1 3 | Lateral Wall, Metaplasia, Squamous | 3 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 2 1 2 1 2 1 1 2 1 2 1 2 2 1 2 2 2 2 1 2 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Infarct | | Mineralization | | Nephropathy | 3 3 2 2 1 3 4 2 1 3 2 2 2 3 2 2 3 2 2 2 1 3 1| Pelvis, Dilatation | | Renal Tubule, Hyperplasia | | Renal Tubule, Necrosis | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + A + + + + + +| Hyperplasia, Adenomatous | | __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + A + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X| Clear Cell Focus | | Degeneration, Fatty | 2 1 1 1 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X| Necrosis | 2 2 | Thrombosis | | Vacuolization Cytoplasmic, Focal | | Bile Duct, Hyperplasia | 1 1 2 3 2 | Centrilobular, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + + + | Inflammation, Chronic Active | | Artery, Mineralization | 3 | Fat, Necrosis | 2 3 2 | __________________________________________________________________________| Oral Mucosa | + | Gingival, Cyst | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 2 2 1 2 2 2 1 2| Basophilic Focus | | Hyperplasia | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + +| Hyperplasia, Squamous | | Mineralization | 1 | Necrosis | 3 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + +| Inflammation, Acute | 2 | Mineralization | 1 1 3 | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 2 2 1 2 1 2 3 1 1 2| Artery, Mineralization | 3 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia | 3 2 2 2 2 4 2 2 1 2| Hypertrophy | 2 2 | Necrosis | | Thrombosis | 3 | Vacuolization Cytoplasmic | 3 2 3 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + +| Hyperplasia | 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 1 2 2 1 2 2 2 3 2 2 2 1 2| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + I + + M + +| Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Lymph Node | + + + | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Hemorrhage | 1 | Renal, Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node, Bronchial | M M M + + M M M + + + M M M M + + + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + M + + + + M + + + M M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | | Thrombosis | | __________________________________________________________________________| Thymus | + + + + I M + + + + M + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Galactocele | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperkeratosis | | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 | Fracture | | Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mineralization | 1 | Necrosis | 2 | Thrombosis | 2 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + A + + + + + + + + + + + +| Inflammation, Chronic Active | | Epiglottis, Metaplasia, Squamous | 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Mineralization | 2 | Alveolar Epithelium, Hyperplasia | 1 1 | Artery, Infiltration Cellular, | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6| DAY ON TEST | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4| | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Histiocyte | | Artery, Mediastinum, Mineralization | 3 | Artery, Perivascular, Inflammation, | | Chronic | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 3 2 2 3 | Thrombosis | 3 1 | Lateral Wall, Hyperplasia | 2 | Lateral Wall, Metaplasia, Squamous | 2 3 2 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 2 2 2 1 1 2 2 1 1 2 1 2 1 1 1 2 1 1 2| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Infarct | 3 | Mineralization | 3 | Nephropathy | 2 3 4 4 1 2 2 2 3 1 3 3 3 4 2 2 2 2 2 2| Pelvis, Dilatation | 3 | Renal Tubule, Hyperplasia | 1 | Renal Tubule, Necrosis | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 48 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 48 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 47 | Hyperplasia, Adenomatous | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 46 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | | 1 2.0| Basophilic Focus | X X X | 37 | Clear Cell Focus | X | 1 | Degeneration, Fatty | 1 2 3 | 18 2.1| Eosinophilic Focus | | 3 | Hepatodiaphragmatic Nodule | | 3 | Mixed Cell Focus | X X X | 11 | Necrosis | | 2 2.0| Thrombosis | | 1 2.0| Vacuolization Cytoplasmic, Focal | 3 | 1 3.0| Bile Duct, Hyperplasia | 2 | 15 1.8| Centrilobular, Necrosis | 1 2 | 8 1.9| __________________________________________________________________________|____________| Mesentery | + | 11 | Inflammation, Chronic Active | | 1 3.0| Artery, Mineralization | | 1 3.0| Fat, Necrosis | | 6 2.5| __________________________________________________________________________|____________| Oral Mucosa | | 2 | Gingival, Cyst | | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + | 49 | Atrophy | 4 1 1 | 20 1.7| Basophilic Focus | | 1 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 49 | Hyperplasia, Squamous | | 2 2.0| Mineralization | | 1 1.0| Necrosis | 4 | 11 2.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 49 | Inflammation, Acute | | 1 2.0| Mineralization | | 3 1.7| Necrosis | | 2 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 2 1 1 | 30 1.6| Artery, Mineralization | | 1 3.0| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Atrophy | | 1 2.0| Hyperplasia | 2 2 2 | 19 2.1| Hypertrophy | 1 | 6 2.2| Necrosis | | 1 2.0| Thrombosis | | 1 3.0| Vacuolization Cytoplasmic | | 9 2.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | 2 2 | 12 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 49 | Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 49 | Hyperplasia | 2 | 4 2.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Cyst | | 1 2.0| Pars Distalis, Hyperplasia | | 3 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 2 1 1 2 2 2 | 37 1.7| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + | 45 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 4 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + | 50 | Cyst | 3 | 3 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + | 50 | Cyst | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | | 10 | Renal, Hemorrhage | | 1 1.0| Renal, Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M M + + | 27 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + | 47 | Infiltration Cellular, Plasma Cell | | 4 2.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + | 47 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 42 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | | 6 1.7| Hematopoietic Cell Proliferation | 3 | 1 3.0| Thrombosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + | 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 50 | Galactocele | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + | 49 | Cyst | | 1 1.0| Hyperkeratosis | | 1 3.0| Inflammation, Chronic Active | 3 | 6 2.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | | 1 4.0| Fracture | | 1 | Hyperostosis | | 2 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | | 2 2.5| Mineralization | | 1 1.0| Necrosis | | 1 2.0| Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 49 | Inflammation, Chronic Active | | 1 4.0| Epiglottis, Metaplasia, Squamous | 3 | 2 2.0| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Inflammation, Chronic Active | | 1 1.0| Mineralization | | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 | 4 1.0| Artery, Infiltration Cellular, | | | Histiocyte | | 1 3.0| Artery, Mediastinum, Mineralization | | 1 3.0| Artery, Perivascular, Inflammation, | | | Chronic | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + | 50 | Inflammation, Suppurative | | 6 2.5| Thrombosis | 3 3 | 8 2.6| Lateral Wall, Hyperplasia | 1 | 4 1.8| Lateral Wall, Metaplasia, Squamous | | 5 2.4| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 1 2 1 | 48 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | 2 | 1 2.0| Infarct | | 1 3.0| Mineralization | | 1 3.0| Nephropathy | 3 2 3 3 3 2 | 49 2.4| Pelvis, Dilatation | | 1 3.0| Renal Tubule, Hyperplasia | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 6| 5| 7| 6| | | DAY ON TEST | 7| 5| 7| 7| 5| 9| | | | 4| 9| 8| 7| 8| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | | Necrosis | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | Angiectasis | 1 4 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Degeneration, Fatty | 1 1 2 2 1 2 2 1 2 3 3 | Eosinophilic Focus | X X | Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X | Inflammation, Granulomatous | 3 | Mixed Cell Focus | X X X | Bile Duct, Hyperplasia | 1 2 2 | Centrilobular, Necrosis | 1 1 2 | __________________________________________________________________________| Mesentery | + + + + | Artery, Inflammation, Chronic Active | 3 | Artery, Mineralization | 2 | Fat, Necrosis | 2 2 3 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + | Atrophy | 2 2 2 2 1 1 1 | Basophilic Focus | X | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | Necrosis | 3 3 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 2 3 | Necrosis | | __________________________________________________________________________| Tongue | + | Hyperplasia | 4 | __________________________________________________________________________| Tooth | + | Developmental Malformation | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + | Cardiomyopathy | 2 2 2 1 1 2 3 1 1 2 2 2 1 2 2 1 3 | Artery, Mineralization | 3 | Atrium, Thrombosis | 3 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + A + + + + | Atrophy | 2 | Hyperplasia | 1 2 2 1 2 2 2 2 2 2 2 | Hypertrophy | 2 2 2 | Necrosis | 2 | Thrombosis | 3 | Vacuolization Cytoplasmic | 2 1 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + A + + + + | Hyperplasia | 2 1 2 2 3 1 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + | Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + | Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + | C-Cell, Hyperplasia | 1 1 2 1 2 2 2 2 3 2 1 2 2 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + + M + + + + + + + + + + + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + | Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + | Thrombosis | | Endometrium, Hyperplasia | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + | Inflammation, Granulomatous | 2 | Thrombosis | 3 | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + | Pancreatic, Inflammation, | | Granulomatous | 2 | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + + + + + + + M + + + + + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + A M + + + | Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + M + + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + | Depletion Cellular | | Fibrosis | 2 3 2 | Hematopoietic Cell Proliferation | 3 3 | Hemorrhage | 3 | Necrosis | | __________________________________________________________________________| Thymus | + M + + + + + + + + M + + + M + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | Fibrous Osteodystrophy | 3 | Hyperostosis | 2 3 3 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + A + + + + | Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | Congestion, Chronic | | Hemorrhage | | Inflammation, Chronic Active | 2 | Mineralization | 3 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia | 2 2 1 2 2 3 2 2 2 2 2 2 2 1 2 1 1 1 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 | Artery, Mediastinum, Mineralization | 4 | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6| DAY ON TEST | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2| | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Fibrosis | 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + A + + + + | Inflammation, Suppurative | 3 | Thrombosis | 2 1 3 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 1 3 2 2 2 2 2 2 1 2 1 2 1 1 1 3 3 2 2 1 | Lateral Wall, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2 2 1 2 2 | Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 2 1 2 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 2 2 1 1 2 1 2 2 2 1 2 3 2 1 2 1 2 2 2 2 | Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | A + | Cornea, Inflammation, Chronic Active | 3 | Cornea, Mineralization | 3 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 2 | Nephropathy | 2 2 2 3 4 3 3 2 2 2 3 3 1 4 1 4 2 3 2 4 | Pelvis, Dilatation | | Renal Tubule, Hyperplasia | 1 | Renal Tubule, Necrosis | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + I + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A +| Inflammation, Acute | 3 | Necrosis | 3 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Degeneration, Fatty | 1 3 2 3 2 1 2 2 1 2| Eosinophilic Focus | | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X X X | Inflammation, Granulomatous | | Mixed Cell Focus | X X X | Bile Duct, Hyperplasia | 1 2 3 1 1 2 2 | Centrilobular, Necrosis | 2 2 | __________________________________________________________________________| Mesentery | + + +| Artery, Inflammation, Chronic Active | | Artery, Mineralization | | Fat, Necrosis | 2 3 3| __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 1 3 | Basophilic Focus | | Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 4 3 3| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | 3 3| __________________________________________________________________________| Tongue | | Hyperplasia | | __________________________________________________________________________| Tooth | | Developmental Malformation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 2 2 2 1 1 1 3 2 2 1 1 2 2 | Artery, Mineralization | | Atrium, Thrombosis | 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 | Hyperplasia | 2 2 2 2 2 2 1 2 2 1 2 1 | Hypertrophy | 2 | Necrosis | | Thrombosis | 2 | Vacuolization Cytoplasmic | 2 2 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 3 2 1 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 2 1 2 1 2 1 2 2 2 1 1 3 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | 2 | Endometrium, Hyperplasia | 4 | __________________________________________________________________________| Vagina | +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | | Thrombosis | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + +| Pancreatic, Inflammation, | | Granulomatous | | Renal, Hemorrhage | | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + M + + + + + + M + M + M + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 4 | Fibrosis | 2 1 2 | Hematopoietic Cell Proliferation | | Hemorrhage | 3| Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 2 | Hyperostosis | 4 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + A + + + + + + + + + + + + + I + + + + + +| Epiglottis, Metaplasia, Squamous | 1 1 2 1 1 1 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 3 | Hemorrhage | 1 | Inflammation, Chronic Active | | Mineralization | | Alveolar Epithelium, Hyperplasia | 1 2 1 | Alveolar Epithelium, Metaplasia | 1 1 2 1 2 1 1 2 2 2 2 2 1 2 1 2 2 1 2 1 1| Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Artery, Mediastinum, Mineralization | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5| DAY ON TEST | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8| | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Fibrosis | 1 1 1 1 1 1 1 2 2 1 2 1 2 1 2 2 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 2 2 2| Thrombosis | 2 2 4 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 2 1 2 2 1 1 2 2 1 1 2 2 2 2 2 2 2 1| Lateral Wall, Hyperplasia | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2| Lateral Wall, Metaplasia, Squamous | 1 2 1 1 2 2 2 1 1 1 1 3| Olfactory Epithelium, Degeneration, | | Hyaline | 3 2 2 2 2 2 2 1 2 2 1 3 2 2 2 1 2 2 3 1 1 2| Olfactory Epithelium, Metaplasia | 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cornea, Inflammation, Chronic Active | | Cornea, Mineralization | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Nephropathy | 4 2 2 4 2 2 4 2 2 2 1 2 3 2 4 1 4 2 3 2 4 1| Pelvis, Dilatation | 2 | Renal Tubule, Hyperplasia | | Renal Tubule, Necrosis | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Parasite Metazoan | | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Inflammation, Acute | | 1 3.0| Necrosis | | 1 3.0| Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 47 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | | 7 2.1| Basophilic Focus | X X X | 39 | Clear Cell Focus | X | 5 | Degeneration, Fatty | 3 | 22 1.9| Eosinophilic Focus | X | 3 | Hematopoietic Cell Proliferation | | 1 2.0| Hepatodiaphragmatic Nodule | X | 7 | Inflammation, Granulomatous | 2 | 2 2.5| Mixed Cell Focus | X X | 8 | Bile Duct, Hyperplasia | 1 2 | 12 1.7| Centrilobular, Necrosis | | 5 1.6| __________________________________________________________________________|____________| Mesentery | | 7 | Artery, Inflammation, Chronic Active | | 1 3.0| Artery, Mineralization | | 1 2.0| Fat, Necrosis | | 6 2.5| __________________________________________________________________________|____________| Oral Mucosa | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + | 49 | Atrophy | 1 2 | 14 1.6| Basophilic Focus | | 1 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Necrosis | 3 | 9 3.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Mineralization | | 2 2.5| Necrosis | | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tongue | | 1 | Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 2 2 2 | 35 1.7| Artery, Mineralization | | 1 3.0| Atrium, Thrombosis | | 4 2.8| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 49 | Atrophy | | 3 2.0| Hyperplasia | 3 2 | 25 1.8| Hypertrophy | 3 | 5 2.2| Necrosis | | 1 2.0| Thrombosis | | 2 2.5| Vacuolization Cytoplasmic | | 7 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 49 | Hyperplasia | 2 | 18 1.9| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 49 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 48 | Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 49 | Pars Distalis, Hyperplasia | 3 3 | 5 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 49 | C-Cell, Hyperplasia | 1 2 2 2 | 38 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 48 | Inflammation, Chronic Active | | 3 2.0| __________________________________________________________________________|____________| Ovary | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cyst | 1 3 | 3 2.7| __________________________________________________________________________|____________| Uterus | + + + + + | 50 | Thrombosis | | 1 2.0| Endometrium, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 49 | Inflammation, Granulomatous | | 1 2.0| Thrombosis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + | 12 | Pancreatic, Inflammation, | | | Granulomatous | | 1 2.0| Renal, Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + | 42 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 44 | Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + | 45 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Depletion Cellular | | 1 4.0| Fibrosis | | 6 2.0| Hematopoietic Cell Proliferation | | 2 3.0| Hemorrhage | | 2 3.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + | 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 50 | __________________________________________________________________________|____________| Skin | + + + + + | 50 | Inflammation, Chronic Active | 4 | 5 2.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Fibrous Osteodystrophy | | 3 2.7| Hyperostosis | 4 | 6 3.2| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 47 | Epiglottis, Metaplasia, Squamous | | 16 1.1| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Congestion, Chronic | | 1 3.0| Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| Mineralization | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 | 5 1.4| Alveolar Epithelium, Metaplasia | 1 2 2 2 | 44 1.7| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 | 38 1.1| Artery, Mediastinum, Mineralization | | 1 4.0| Interstitium, Fibrosis | 1 1 1 1 | 41 1.2| __________________________________________________________________________|____________| Nose | + + + + + | 49 | Inflammation, Suppurative | 2 | 7 2.0| Thrombosis | | 7 2.3| Goblet Cell, Lateral Wall, | | | Hyperplasia | 2 1 1 2 3 | 47 1.8| Lateral Wall, Hyperplasia | 2 1 2 2 2 | 49 1.9| Lateral Wall, Metaplasia, Squamous | 1 1 1 1 | 25 1.3| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 2 | 48 1.8| Olfactory Epithelium, Metaplasia | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic Active | | 1 3.0| Cornea, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Mineralization | | 1 2.0| Nephropathy | 2 2 2 2 4 | 47 2.5| Pelvis, Dilatation | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 8| 6| 5| 6| 8| 8| | | DAY ON TEST | 1| 2| 8| 1| 7| 7| | | | 7| 3| 0| 6| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Hyperplasia | | 1 1.0| Renal Tubule, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Degeneration, Cystic | 3 2 2 3 | Degeneration, Fatty | 2 3 2 1 1 2 2 | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X X X X X X X X| Mixed Cell Focus | X X X X| Necrosis | 1 2 1 | Bile Duct, Hyperplasia | 2 2 1 2 1 1 2 | Centrilobular, Necrosis | 2 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 1 1 2 2 1 2 2 | Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 | Necrosis | 3 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 1 2 | Necrosis | 3 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 2 1 1 1 1 1 1 2 1 2 1 1 2 2| Artery, Mineralization | 3 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 1 3 2 1 2 2 1 1 1 2 2 2| Hypertrophy | 1 2 2 2 | Necrosis | | Vacuolization Cytoplasmic | 2 2 1 2 2 2| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 1 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + M + M + + + + +| Hyperplasia | 2 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia | 3 2 2 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 4 1 1 1 1 2 1 2 1 2| Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia | 2| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Lymph Node | + + + + + | Renal, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | M + M + M M M M + + M + + + + + M + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 3 | Hyperostosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Gliosis | 3| Mineralization | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 1 2 1 1 2 2 3 3 1 3 3 2 2 1 2 1 2 2 3 2 2 2 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 4 | Alveolar Epithelium, Hyperplasia | 3 | Alveolar Epithelium, Metaplasia | 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3| Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Artery, Mediastinum, Mineralization | 4 | Interstitium, Fibrosis | 2 2 3 3 2 2 3 3 3 2 3 3 2 3 3 2 3 3 2 3 3 2 2 3| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 2 1 2 2 | Thrombosis | 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 3 2 2 3 2 3 2 2 3 3 2 2 2 3 3 2 3 2 2 3 2 2 2 2| Lateral Wall, Hyperplasia | 3 3 2 3 2 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 2| Lateral Wall, Metaplasia, Squamous | 2 3 1 2 1 2 2 1 1 2 1 2 1 2 3 1 2 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 4 4 3 3 4 3 3 3 3 3 3 3 2 3 1 3 3 4 4 4 3 3 3 3| Olfactory Epithelium, Metaplasia | 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7| DAY ON TEST | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3| | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | | Degeneration | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Nephropathy | 1 2 4 2 3 4 4 1 2 3 4 3 4 3 2 1 2 1 2 1 3 2 3| Thrombosis | 2 | Pelvis, Inflammation, Acute | | Renal Tubule, Hyperplasia | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + I + + + + + I + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic | 2 | Degeneration, Fatty | 3 2 2 | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X X X X | Mixed Cell Focus | X X X X | Necrosis | | Bile Duct, Hyperplasia | 1 2 2 | Centrilobular, Necrosis | 2 1 1 1 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 1 2 1 2 2 1 2 | Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 3 | Necrosis | 4 1 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Necrosis | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 2 2 2 1 1 2 1 2 2 1 | Artery, Mineralization | | Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia | 2 1 2 1 1 2 2 2 2 1 | Hypertrophy | 3 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 3 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 1 | Pars Distalis, Hyperplasia | 2 2 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Inflammation, Granulomatous | | __________________________________________________________________________| Lymph Node | + + | Renal, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + M + + M M M + + M M + M + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + M + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + M + + + + + M + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 3| __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Galactocele | 3 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Hyperostosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Gliosis | | Mineralization | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 1 2 3 2 2 1 3 4 2 3 2 1 2 1 2 4 1 3 2 1| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 4 1 | Mineralization | | Alveolar Epithelium, Hyperplasia | 3 | Alveolar Epithelium, Metaplasia | 2 3 4 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 2| Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1| Artery, Mediastinum, Mineralization | | Interstitium, Fibrosis | 2 2 4 2 2 2 3 2 2 3 3 3 2 3 2 3 3 2 1 3 2| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 3 3 | Thrombosis | 3 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 2 1 3 2 2 3 2 3 3 3 2 2 2 3 3 2 2 3 3 2| Lateral Wall, Hyperplasia | 3 3 2 3 2 3 3 3 3 2 2 3 3 3 3 3 3 2 3 3 3| Lateral Wall, Metaplasia, Squamous | 1 2 2 1 2 2 1 2 2 1 1 1 1 1| Olfactory Epithelium, Degeneration, | | Hyaline | 4 4 2 3 4 3 3 3 4 4 3 3 3 3 4 4 3 4 3 4 3| Olfactory Epithelium, Metaplasia | 2 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2| DAY ON TEST | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8| | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Mineralization | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 2 | Degeneration | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Nephropathy | 1 1 4 2 2 2 3 3 2 2 3 2 3 3 2 2 1 3 1 2 1| Thrombosis | | Pelvis, Inflammation, Acute | 3 | Renal Tubule, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 50 | Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 47 | Parasite Metazoan | X | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 50 | Parasite Metazoan | | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | 3 | 3 2.0| Basophilic Focus | X X X X | 42 | Clear Cell Focus | | 5 | Degeneration, Cystic | | 5 2.4| Degeneration, Fatty | 3 | 11 2.1| Eosinophilic Focus | | 4 | Hepatodiaphragmatic Nodule | | 12 | Mixed Cell Focus | X | 9 | Necrosis | | 3 1.3| Bile Duct, Hyperplasia | | 10 1.6| Centrilobular, Necrosis | | 5 1.4| __________________________________________________________________________|____________| Mesentery | | 4 | Fat, Necrosis | | 4 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Atrophy | 1 2 | 21 1.5| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | Basophilic Focus | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Hyperplasia, Squamous | | 3 3.0| Necrosis | 3 | 7 2.9| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Mineralization | | 4 1.8| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Aorta, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 1 1 1 1 | 35 1.4| Artery, Mineralization | | 1 3.0| Atrium, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Atrophy | | 1 3.0| Hyperplasia | | 22 1.6| Hypertrophy | 1 | 6 1.8| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 | 8 1.9| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Hyperplasia | 1 | 13 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + | 44 | Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Cyst | | 2 1.0| Pars Distalis, Hyperplasia | | 10 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Hyperplasia | 3 1 1 1 | 30 1.3| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + | 47 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Ovary | + + + + + | 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + | 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Atrophy | | 1 3.0| Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 9 | Renal, Infiltration Cellular, Plasma | | | Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + | 34 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + | 46 | Infiltration Cellular, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + | 45 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Fibrosis | | 3 2.0| Hematopoietic Cell Proliferation | | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + | 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 50 | Galactocele | | 3 3.0| __________________________________________________________________________|____________| Skin | + + + + + | 50 | Inflammation, Chronic Active | | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Fibrous Osteodystrophy | | 2 2.5| Hyperostosis | | 2 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Gliosis | | 1 3.0| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Epiglottis, Metaplasia, Squamous | 1 3 1 1 2 | 48 2.0| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Inflammation, Chronic Active | | 2 2.5| Mineralization | | 1 4.0| Alveolar Epithelium, Hyperplasia | | 2 3.0| Alveolar Epithelium, Metaplasia | 3 3 3 3 3 | 50 2.9| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 4| 5| | | DAY ON TEST | 2| 5| 1| 7| 6| 6| | | | 3| 1| 3| 5| 7| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 2 1 2 | 49 2.0| Artery, Mediastinum, Mineralization | | 1 4.0| Interstitium, Fibrosis | 3 2 3 2 2 | 50 2.5| __________________________________________________________________________|____________| Nose | + + + + + | 50 | Inflammation, Suppurative | 1 | 10 1.9| Thrombosis | | 3 2.7| Goblet Cell, Lateral Wall, | | | Hyperplasia | 2 3 3 3 3 | 50 2.4| Lateral Wall, Hyperplasia | 3 3 3 3 3 | 50 2.8| Lateral Wall, Metaplasia, Squamous | 2 2 | 35 1.6| Olfactory Epithelium, Degeneration, | | | Hyaline | 3 4 3 3 3 | 50 3.2| Olfactory Epithelium, Metaplasia | | 4 2.0| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 1 2.0| Degeneration | | 2 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Mineralization | | 1 2.0| Nephropathy | 2 3 4 2 2 | 49 2.3| Thrombosis | | 1 2.0| Pelvis, Inflammation, Acute | | 1 3.0| Renal Tubule, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 3 2 2 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Mineralization | 2 2 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 | Basophilic Focus | X X X X X X X X X X X X X | Clear Cell Focus | X | Degeneration, Cystic | 2 1 2 2 2 2 3 2 2 | Degeneration, Fatty | 2 1 2 2 2 2 1 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X | Necrosis | | Thrombosis | | Vacuolization Cytoplasmic, Focal | | Bile Duct, Hyperplasia | 2 1 2 2 3 1 2 1 2 3 3 2 1 1 3 3 3 2 4| Centrilobular, Necrosis | 3 2 1 2 | __________________________________________________________________________| Mesentery | + + + + + + + + + | Inflammation, Chronic Active | | Artery, Mineralization | 4 3 3 3 3 | Fat, Necrosis | 1 2 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 3 2 2 2 2 2 2 1 4 3 1 2 | Hyperplasia | 2 2 | Thrombosis | 2 | Artery, Inflammation | 4 | Artery, Mineralization | 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Mineralization | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 4 2 3 2 | Necrosis | 2 2 3 1 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 2 3 3 3 4 4 3 4 3 | Necrosis | 3 2 1 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + | Aorta, Mineralization | 3 4 4 4 4 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 2 1 1 3 1 2 1 3 2 3 3 3 1 3 1 3 3 3 3| Mineralization | | Artery, Mineralization | 2 3 4 4 3 | Atrium, Thrombosis | 3 4 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 1 2 2 2 2 2 2 1 2 2 | Hypertrophy | 2 2 1 1 1 | Vacuolization Cytoplasmic | 2 2 3 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 3 2 2 2 1 2 1 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 4 3 4 4 4 4 4 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Thrombosis | | Pars Distalis, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 3 1 2 1 1 1 1 1 2 1 2 2 1 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 3 | __________________________________________________________________________| Penis | + + | Inflammation, Acute | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 | Inflammation, Chronic Active | 3 2 3 2 4 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 3 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 2 3 4 4 | Artery, Inflammation, Chronic Active | 2 2 3 | Artery, Mineralization | 3 | Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + | Renal, Hemorrhage | 2 2 2 2 2 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + M + + + + + + + M M + + + + + M M M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + +| Infiltration Cellular, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + M + + M +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 3 3 2 3 3 | Hemorrhage | | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M + M + + + + M + + + M + + + + + + M +| Galactocele | | Hyperplasia, Atypical | | Inflammation, Chronic Active | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hyperkeratosis | 4 3 3 | Inflammation, Chronic Active | 3 4 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 3 3 4 3 3 3 3 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Hemosiderin | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 2 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | | Hemorrhage | 3 | Inflammation, Chronic Active | 1 | Mineralization | 2 3 4 4 2 3 | Necrosis | | Thrombosis | 3 | Alveolar Epithelium, Hyperplasia | 2 4 | Artery, Mediastinum, Mineralization | 4 3 4 4 4 | Artery, Mediastinum, Thrombosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 4 3 2 1 2 2 3 3 | Thrombosis | 2 4 3 1 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 | Lateral Wall, Hyperplasia | 2 2 1 1 2 1 | Lateral Wall, Metaplasia, Squamous | 2 4 2 4 2 3 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 2 2 2 2 1 1 2 2 2 1 1 2 2 1 2 1 2 1 1 2 2 2| Olfactory Epithelium, Metaplasia | 1 1 1 3 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 3 | Hyperplasia, Oncocytic | | Mineralization | 2 2 4 3 4 4 3 | Nephropathy | 3 4 3 3 3 3 4 3 4 2 4 4 4 4 4 4 4 3 4 2 2 4 4 4| Pelvis, Dilatation | | Pelvis, Inflammation, Acute | 2 | Renal Tubule, Hyperplasia | 1 3 1 2 | Renal Tubule, Hyperplasia, Oncocytic | | Transitional Epithelium, Hyperplasia | 1 2 | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5| DAY ON TEST | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8| | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 2 | Transitional Epithelium, Hyperplasia | 2 3 | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + +| Mineralization | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + +| Inflammation, Acute | 3 | Mineralization | 2 2 | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + +| Inflammation, Acute | 2 | Mineralization | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X| Clear Cell Focus | | Degeneration, Cystic | 2 1 2 2 2 | Degeneration, Fatty | 1 2 2 1 1 3 3 | Eosinophilic Focus | | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | 1 | Thrombosis | 2 | Vacuolization Cytoplasmic, Focal | 2 | Bile Duct, Hyperplasia | 1 3 3 3 4 2 2 1 3 2 2 3 1 1 3 1| Centrilobular, Necrosis | 1 1 | __________________________________________________________________________| Mesentery | + + + + + + | Inflammation, Chronic Active | 2 | Artery, Mineralization | 2 | Fat, Necrosis | 3 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 3 2 3 1 2 2 3 1 2 | Hyperplasia | 2 | Thrombosis | | Artery, Inflammation | | Artery, Mineralization | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + +| Artery, Mineralization | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Necrosis | 2 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Mineralization | 3 3 3 3 | Necrosis | 2 3 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | Aorta, Mineralization | 3 4 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 3 2 2 1 2 2 3 2 3 2 2 3 2 2 2 | Mineralization | 2 | Artery, Mineralization | 3 3 3 | Atrium, Thrombosis | 3 3 2 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Hyperplasia | 1 2 2 2 2 2 1 2| Hypertrophy | 1 | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 4 1 3 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + +| Hyperplasia | 3 2 3 4 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| Mineralization | | Thrombosis | 3 | Pars Distalis, Hyperplasia | 2 3 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 4 2 3 1 1 1 1| Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Penis | + + | Inflammation, Acute | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 3 3 | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 2 | Inflammation, Chronic Active | 3 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Mineralization | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Artery, Inflammation, Chronic Active | 3 | Artery, Mineralization | | Interstitial Cell, Hyperplasia | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M M + + M + + + + M + M + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 3 2| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +| Ectasia | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 3 4 2 3 | Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + M + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + M + + + + + + M + M M M M M M| Galactocele | 2 2 3 | Hyperplasia, Atypical | 2 | Inflammation, Chronic Active | 4 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Hyperkeratosis | 2 | Inflammation, Chronic Active | 2 2 4 3 4 3 3 3 3 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 3 2 4 3 3 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + +| Pigmentation, Hemosiderin | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 4 | Hemorrhage | 3 | Inflammation, Chronic Active | 1 2 | Mineralization | 2 3 2 2 | Necrosis | 3 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 2 1 | Artery, Mediastinum, Mineralization | 3 4 | Artery, Mediastinum, Thrombosis | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 3 3 2 | Thrombosis | 3 2 4 3 1 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | | Lateral Wall, Hyperplasia | 2 1 2 1 | Lateral Wall, Metaplasia, Squamous | 3 3 | Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 1 1 1 2 1 2 2 1 1 1 2 2 1 2 2 1 1 2 2| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Degeneration | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Oncocytic | 2 | Mineralization | 2 3 2 | Nephropathy | 3 4 4 2 3 4 3 3 3 4 4 4 4 3 4 4 2 2 2 2 3| Pelvis, Dilatation | | Pelvis, Inflammation, Acute | | Renal Tubule, Hyperplasia | 3 1 | Renal Tubule, Hyperplasia, Oncocytic | 3 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4| DAY ON TEST | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6| | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 3 | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 49 | Mineralization | | 5 2.4| Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 49 | Inflammation, Acute | | 1 3.0| Mineralization | | 2 2.0| Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 49 | Inflammation, Acute | | 1 2.0| Mineralization | | 3 2.0| __________________________________________________________________________|____________| Liver | + + + + + | 50 | Angiectasis | | 2 1.5| Basophilic Focus | X | 23 | Clear Cell Focus | | 1 | Degeneration, Cystic | 2 | 15 1.9| Degeneration, Fatty | | 14 1.8| Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | | 3 | Mixed Cell Focus | X | 3 | Necrosis | | 1 1.0| Thrombosis | 1 | 2 1.5| Vacuolization Cytoplasmic, Focal | | 1 2.0| Bile Duct, Hyperplasia | 3 3 2 3 | 39 2.2| Centrilobular, Necrosis | 2 | 7 1.7| __________________________________________________________________________|____________| Mesentery | + | 16 | Inflammation, Chronic Active | | 1 2.0| Artery, Mineralization | | 6 3.0| Fat, Necrosis | 2 | 8 2.1| __________________________________________________________________________|____________| Pancreas | + + + + + | 50 | Atrophy | 2 2 2 | 28 2.2| Hyperplasia | | 3 2.0| Thrombosis | | 1 2.0| Artery, Inflammation | | 1 4.0| Artery, Mineralization | | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Artery, Mineralization | | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 50 | Mineralization | | 7 2.6| Necrosis | | 9 2.6| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 50 | Mineralization | | 13 3.2| Necrosis | | 6 2.2| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 9 | Aorta, Mineralization | | 9 3.8| __________________________________________________________________________|____________| Heart | + + + + + | 50 | Cardiomyopathy | 2 3 | 40 2.2| Mineralization | | 1 2.0| Artery, Mineralization | | 8 3.1| Atrium, Thrombosis | | 7 2.9| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 50 | Atrophy | | 1 3.0| Hyperplasia | | 18 1.8| Hypertrophy | 1 | 7 1.3| Vacuolization Cytoplasmic | | 5 2.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 50 | Hyperplasia | 3 2 | 21 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 50 | Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 49 | Hyperplasia | 2 | 15 3.4| __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 50 | Mineralization | | 1 2.0| Thrombosis | | 1 3.0| Pars Distalis, Hyperplasia | 3 3 | 7 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 50 | C-Cell, Hyperplasia | 1 1 | 28 1.5| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + | 50 | Granuloma Sperm | | 2 2.5| __________________________________________________________________________|____________| Penis | | 4 | Inflammation, Acute | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + | 50 | Inflammation, Chronic Active | | 5 2.8| __________________________________________________________________________|____________| Prostate | + + + + + | 50 | Hyperplasia | | 6 2.2| Inflammation, Chronic Active | 1 4 | 10 2.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 50 | Inflammation, Chronic Active | | 1 2.0| Mineralization | | 3 2.7| __________________________________________________________________________|____________| Testes | + + + + + | 50 | Atrophy | 2 | 9 3.0| Artery, Inflammation, Chronic Active | | 4 2.5| Artery, Mineralization | | 1 3.0| Interstitial Cell, Hyperplasia | 2 | 10 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + + + + | 20 | Renal, Hemorrhage | | 7 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M | 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 48 | Infiltration Cellular, Plasma Cell | | 3 2.7| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 49 | Ectasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + | 45 | __________________________________________________________________________|____________| Spleen | + + + + + | 50 | Fibrosis | 2 3 | 16 2.7| Hemorrhage | 4 | 1 4.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + | 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + | 31 | Galactocele | 3 | 4 2.5| Hyperplasia, Atypical | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + | 50 | Fibrosis | | 1 3.0| Hyperkeratosis | | 4 3.0| Inflammation, Chronic Active | 3 3 | 16 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 50 | Fibrous Osteodystrophy | | 15 2.7| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 50 | Pigmentation, Hemosiderin | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 50 | Mineralization | | 5 2.4| __________________________________________________________________________|____________| Lung | + + + + + | 50 | Congestion, Chronic | | 1 4.0| Hemorrhage | | 2 3.0| Inflammation, Chronic Active | | 3 1.3| Mineralization | | 10 2.7| Necrosis | | 1 3.0| Thrombosis | | 1 3.0| Alveolar Epithelium, Hyperplasia | | 4 2.3| Artery, Mediastinum, Mineralization | | 7 3.7| Artery, Mediastinum, Thrombosis | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + | 50 | Inflammation, Suppurative | 2 | 14 2.4| Thrombosis | | 11 2.4| Goblet Cell, Lateral Wall, | | | Hyperplasia | | 1 1.0| Lateral Wall, Hyperplasia | | 10 1.5| Lateral Wall, Metaplasia, Squamous | 1 1 | 10 2.5| Olfactory Epithelium, Degeneration, | | | Hyaline | 2 1 2 2 2 | 49 1.6| Olfactory Epithelium, Metaplasia | | 5 1.8| __________________________________________________________________________|____________| Trachea | + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 5| 5| 5| 6| 7| | | DAY ON TEST | 3| 2| 4| 8| 2| 9| | | | 6| 1| 4| 0| 3| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 8| 8| 8| 8| 8| 8| | A | CONTROL | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Mineralization | | 3 2.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Degeneration | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 50 | Cyst | | 3 2.7| Hyperplasia, Oncocytic | | 1 2.0| Mineralization | | 10 2.9| Nephropathy | 3 2 2 2 2 | 50 3.2| Pelvis, Dilatation | 2 | 1 2.0| Pelvis, Inflammation, Acute | | 1 2.0| Renal Tubule, Hyperplasia | | 6 1.8| Renal Tubule, Hyperplasia, Oncocytic | | 1 3.0| Transitional Epithelium, Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 50 | Hemorrhage | 4 | 1 4.0| Inflammation, Chronic Active | | 2 2.5| Transitional Epithelium, Hyperplasia | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | 3 | Parasite Metazoan | X | Artery, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | 4 | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + | Angiectasis | 1 2 | Basophilic Focus | X X X X X X X X X | Degeneration, Cystic | 2 2 4 2 2 | Degeneration, Fatty | 2 1 2 2 2 3 2 2 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | | Infiltration Cellular, Mixed Cell | | Mixed Cell Focus | X X | Necrosis | 2 3 2 | Vacuolization Cytoplasmic, Focal | | Bile Duct, Hyperplasia | 2 4 1 3 1 1 1 2 2 3 2 2 1 2 1 3 3 | Centrilobular, Necrosis | 2 2 | __________________________________________________________________________| Mesentery | + + + + + + + + + + | Artery, Inflammation, Chronic Active | 4 | Artery, Mineralization | 3 3 | Fat, Necrosis | 2 2 2 2 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | Atrophy | 2 1 1 2 1 1 2 1 3 3 2 2 1 4 | Basophilic Focus | | Hyperplasia | 2 2 2 | Inflammation, Suppurative | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | Diverticulum | X | Hyperplasia, Squamous | 3 | Mineralization | 1 2 | Necrosis | 4 3 4 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Acute | | Mineralization | 3 4 3 | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Necrosis | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + | Aorta, Mineralization | 4 1 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + | Cardiomyopathy | 2 2 2 2 1 2 2 3 1 3 2 2 3 2 1 1 2 3 2 2 2 2 2 | Inflammation, Chronic Active | | Artery, Mineralization | 3 1 1 3 | Atrium, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + | Atrophy | 3 | Hyperplasia | 2 1 2 2 2 2 1 1 2 1 | Hypertrophy | 2 | Necrosis | | Vacuolization Cytoplasmic | 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 1 2 2 1 3 1 1 3 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 3 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 4 2 2 4 4 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + | Thrombosis | 4 | Pars Distalis, Hyperplasia | 4 2 3 | Pars Distalis, Necrosis | 4 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 2 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Penis | + + | Inflammation, Acute | 3 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + M + + + M + + + + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + | Atrophy | 3 4 3 | Artery, Inflammation, Chronic Active | 3 2 2 | Interstitial Cell, Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + | Lumbar, Hemorrhage | 1 | Renal, Hemorrhage | 2 | Renal, Pigmentation | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + M + + M + + + M M + + M + + M + + M | Hemorrhage | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + M + | Hemorrhage | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | Fibrosis | 2 3 3 | Hematopoietic Cell Proliferation | | Hemorrhage | 3 | Necrosis | | __________________________________________________________________________| Thymus | + + + + + M M + + + + + + + + + M + + M + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M I + M M M M + + + + M + M + M M M + + M | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 1 4 | Prepuce, Inflammation, Acute | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | Fibrous Osteodystrophy | 3 1 3 2 | Hyperostosis | 2 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 2 | Necrosis | 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + A + + + + + + + + + + + + + + + + + + + + + | Mineralization | 1 | Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + | Congestion, Chronic | | Foreign Body | | Hemorrhage | | Inflammation, Suppurative | | Mineralization | 3 1 3 | Alveolar Epithelium, Hyperplasia | 2 1 | Alveolar Epithelium, Metaplasia | 2 2 1 2 2 2 2 2 3 2 2 2 1 2 2 2 2 2 1 2 1 1 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 | Artery, Mediastinum, Mineralization | | Interstitium, Fibrosis | 2 1 1 2 2 2 2 2 2 2 2 1 1 2 1 2 2 1 1 2 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Suppurative | 2 2 2 1 2 2 1 | Thrombosis | 2 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 1 1 2 2 1 1 1 2 2 1 1 2 1 1 1 2 2 2 2 2 1 1 | Lateral Wall, Hyperplasia | 2 2 1 2 2 1 2 2 2 1 3 2 1 3 2 1 1 2 1 3 2 3 2 1 | Lateral Wall, Metaplasia, Squamous | 3 2 2 2 1 1 1 3 3 2 1 1 | Olfactory Epithelium, Degeneration, | | Hyaline | 2 1 1 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 1 1 1 1 2 1 | Olfactory Epithelium, Metaplasia | 2 | __________________________________________________________________________| Pleura | + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 | Degeneration | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | Cyst | 2 | Mineralization | 2 2 3 | Nephropathy | 4 4 1 3 3 3 4 4 4 3 3 4 4 2 3 2 2 4 2 3 2 4 1 4 | Renal Tubule, Hyperplasia | 2 2 2 | Renal Tubule, Hyperplasia, Oncocytic | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6| DAY ON TEST | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2| | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Infiltration Cellular, | | Polymorphonuclear | 2 | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X X X | Artery, Inflammation, Chronic Active | | __________________________________________________________________________| Intestine Small, Duodenum | + A A + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + A A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + A A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 | Basophilic Focus | X X X X X X X X | Degeneration, Cystic | 3 2 2 3 2 2 | Degeneration, Fatty | 3 3 3| Eosinophilic Focus | | Hepatodiaphragmatic Nodule | X | Infiltration Cellular, Mixed Cell | 3 | Mixed Cell Focus | | Necrosis | 3 | Vacuolization Cytoplasmic, Focal | 1 3 | Bile Duct, Hyperplasia | 1 3 1 1 2 1 2 1 2 2 3 1 1 1 2 2 2| Centrilobular, Necrosis | 4 2 2 2 3 2 2 | __________________________________________________________________________| Mesentery | + + + + + | Artery, Inflammation, Chronic Active | | Artery, Mineralization | 3 | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 2 1 2 2 2 3 2 2 1 2 2| Basophilic Focus | X | Hyperplasia | | Inflammation, Suppurative | 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Hyperplasia, Squamous | | Mineralization | | Necrosis | 3 1 4| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Mineralization | 3 3 1 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Necrosis | 3 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Aorta, Mineralization | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 3 2 2 2 3 1 2 2 3 1 1 2 3 2 2| Inflammation, Chronic Active | 4 | Artery, Mineralization | 2 2 | Atrium, Thrombosis | 4 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 1 1 2 2 3 1 2 2 1| Hypertrophy | 1 2 | Necrosis | 2 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 3 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Thrombosis | | Pars Distalis, Hyperplasia | 2 1 2 3 | Pars Distalis, Necrosis | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 1 2 2 1| Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + + | Inflammation, Acute | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 4 | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 4 | Artery, Inflammation, Chronic Active | | Interstitial Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + +| Lumbar, Hemorrhage | | Renal, Hemorrhage | 2 2 | Renal, Pigmentation | 2| __________________________________________________________________________| Lymph Node, Bronchial | + + + + M M M + M + + + + + + + + + M +| Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + +| Hemorrhage | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + +| Hemorrhage | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Hematopoietic Cell Proliferation | 3 | Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M M M + + M M M M M + M + M + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Prepuce, Inflammation, Acute | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 3 2 | Hyperostosis | | __________________________________________________________________________| Skeletal Muscle | + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| Mineralization | | Necrosis | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + A + + + + + + + + + + + + + + + + + +| Mineralization | | Epiglottis, Metaplasia, Squamous | 1 3 2 1 1 1 1 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Congestion, Chronic | 3 | Foreign Body | X | Hemorrhage | 3 | Inflammation, Suppurative | 4 | Mineralization | 1 2 1 | Alveolar Epithelium, Hyperplasia | 2 | Alveolar Epithelium, Metaplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3| Alveolus, Infiltration Cellular, | | Histiocyte | 2 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1| Artery, Mediastinum, Mineralization | 3 | Interstitium, Fibrosis | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2| __________________________________________________________________________| Nose | + A + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 1 2 2 2 | Thrombosis | 3 4 2 3 | Goblet Cell, Lateral Wall, | | Hyperplasia | 1 1 1 1 1 1 1 2 2 2 2 1 2 3 2 1 2 1| Lateral Wall, Hyperplasia | 2 2 1 1 1 1 1 3 1 2 2 2 3 3 2 2 3 2| Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 3 3 1| Olfactory Epithelium, Degeneration, | | Hyaline | 1 1 2 2 2 1 1 2 2 1 2 2 1 2 2 2 2 3 2| Olfactory Epithelium, Metaplasia | | __________________________________________________________________________| Pleura | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | Degeneration | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 | Mineralization | 1 2 | Nephropathy | 4 2 2 4 4 4 2 2 2 2 4 2 3 3 2 2 4 2 3| Renal Tubule, Hyperplasia | 2 | Renal Tubule, Hyperplasia, Oncocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7| DAY ON TEST | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0| | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Infiltration Cellular, | | Polymorphonuclear | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 50 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 50 | Inflammation, Acute | | 1 3.0| Parasite Metazoan | X | 5 | Artery, Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 48 | Inflammation, Acute | | 2 3.5| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 47 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | 2 | 6 2.0| Basophilic Focus | X | 18 | Degeneration, Cystic | 1 2 | 13 2.2| Degeneration, Fatty | 3 1 | 13 2.2| Eosinophilic Focus | | 1 | Hepatodiaphragmatic Nodule | X | 2 | Infiltration Cellular, Mixed Cell | | 1 3.0| Mixed Cell Focus | | 2 | Necrosis | | 4 2.5| Vacuolization Cytoplasmic, Focal | | 2 2.0| Bile Duct, Hyperplasia | 2 1 2 2 | 38 1.8| Centrilobular, Necrosis | 1 | 10 2.2| __________________________________________________________________________|____________| Mesentery | + + | 17 | Artery, Inflammation, Chronic Active | | 1 4.0| Artery, Mineralization | | 3 3.0| Fat, Necrosis | 2 2 | 10 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Atrophy | 2 | 28 2.0| Basophilic Focus | | 1 | Hyperplasia | | 3 2.0| Inflammation, Suppurative | | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Diverticulum | | 1 | Hyperplasia, Squamous | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | | 2 1.5| Necrosis | 4 3 4 | 10 3.2| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Inflammation, Acute | | 1 2.0| Mineralization | 2 | 7 2.7| Necrosis | 1 | 4 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | Aorta, Mineralization | | 4 2.8| __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 3 1 2 2 2 | 44 2.0| Inflammation, Chronic Active | | 1 4.0| Artery, Mineralization | | 6 2.0| Atrium, Thrombosis | | 3 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 49 | Atrophy | 4 | 2 3.5| Hyperplasia | 2 1 1 | 22 1.6| Hypertrophy | 2 2 | 5 1.8| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | | 2 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 49 | Hyperplasia | 2 2 1 | 19 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Hyperplasia | | 4 2.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 50 | Hyperplasia | 3 | 10 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + M + | 48 | Thrombosis | | 1 4.0| Pars Distalis, Hyperplasia | 2 3 | 9 2.4| Pars Distalis, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 2 1 | 29 1.2| Follicular Cell, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | __________________________________________________________________________|____________| Penis | | 4 | Inflammation, Acute | | 2 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 48 | Inflammation, Chronic Active | | 2 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | | 3 2.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | Mineralization | | 2 1.5| __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Atrophy | | 5 3.2| Artery, Inflammation, Chronic Active | | 3 2.3| Interstitial Cell, Hyperplasia | | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + | 13 | Lumbar, Hemorrhage | | 1 1.0| Renal, Hemorrhage | 2 | 4 2.0| Renal, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + | 37 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 47 | Hemorrhage | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M + | 48 | Hemorrhage | | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | 2 | 6 2.3| Hematopoietic Cell Proliferation | | 1 3.0| Hemorrhage | | 1 3.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + M M | 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M M + M | 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + | 50 | Inflammation, Chronic Active | | 3 2.7| Prepuce, Inflammation, Acute | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | 1 | 8 2.0| Hyperostosis | | 1 2.0| __________________________________________________________________________|____________| Skeletal Muscle | | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Mineralization | | 1 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + | 48 | Mineralization | | 1 1.0| Epiglottis, Metaplasia, Squamous | 2 | 20 1.3| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Congestion, Chronic | | 1 3.0| Foreign Body | | 1 | Hemorrhage | 1 | 2 2.0| Inflammation, Suppurative | | 1 4.0| Mineralization | | 6 1.8| Alveolar Epithelium, Hyperplasia | 2 | 4 1.8| Alveolar Epithelium, Metaplasia | 1 2 2 2 2 | 45 1.9| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 1 1 1 | 38 1.2| Artery, Mediastinum, Mineralization | | 1 3.0| Interstitium, Fibrosis | 1 2 2 1 1 | 44 1.7| __________________________________________________________________________|____________| Nose | + + + + + + | 49 | Inflammation, Suppurative | 1 | 13 1.8| Thrombosis | | 6 2.5| Goblet Cell, Lateral Wall, | | | Hyperplasia | 1 2 2 2 1 | 46 1.5| Lateral Wall, Hyperplasia | 2 2 2 2 2 2 | 48 1.9| Lateral Wall, Metaplasia, Squamous | 1 1 1 | 23 1.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 3| 6| 6| | | DAY ON TEST | 1| 9| 2| 4| 7| 6| | | | 1| 5| 2| 6| 0| 3| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| | A | 0.5 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Olfactory Epithelium, Degeneration, | | | Hyaline | 2 2 2 2 2 2 | 49 1.7| Olfactory Epithelium, Metaplasia | | 1 2.0| __________________________________________________________________________|____________| Pleura | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 1 3.0| Degeneration | | 1 3.0| Retina, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | | 3 2.0| Mineralization | | 5 2.0| Nephropathy | 2 4 3 3 3 3 | 49 2.9| Renal Tubule, Hyperplasia | | 4 2.0| Renal Tubule, Hyperplasia, Oncocytic | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 50 | Infiltration Cellular, | | | Polymorphonuclear | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + I + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 | Basophilic Focus | X X X X X X X X X X X X| Degeneration, Cystic | 3 3 1 2 | Degeneration, Fatty | 1 1 1 3| Eosinophilic Focus | X X X | Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | | Necrosis | 1 | Thrombosis | 2 | Bile Duct, Hyperplasia | 3 3 2 3 2 2 2 2 1 3 2 2 3 2 | Centrilobular, Necrosis | 2 2 1 | __________________________________________________________________________| Mesentery | + + + | Fat, Hemorrhage | | Fat, Necrosis | 2 2 | __________________________________________________________________________| Oral Mucosa | + | Gingival, Hyperplasia, Squamous | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 1 2 2 3 1 2 2 2 2 3 1| Basophilic Focus | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Duct, Metaplasia, Squamous | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Hyperplasia, Squamous | | Necrosis | 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 3 3| Necrosis | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + +| Aorta, Mineralization | 3 2| _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 1 2 2 2 2 3 2 1 1 1 3| Artery, Mineralization | 3 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 2 1 2 1 2 2 2| Hypertrophy | 2 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 3 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 4| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mineralization | 2 | Pars Distalis, Hyperplasia | 2 3 4 3 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1| Follicular Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 3 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Artery, Inflammation, Chronic Active | 3 | Interstitial Cell, Hyperplasia | 1 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + | Iliac, Infiltration Cellular, Plasma | | Cell | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + M + + + M + + M + + + + M| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M| Hemorrhage | | Necrosis | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 3 2 2 3 | Hemorrhage | 4 | Necrosis | 4 4 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + + + M M + + M + + + + M M M + M + +| Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + I + + + + +| Cyst | | Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 3| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mineralization | | Necrosis | | Meninges, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + +| Epiglottis, Metaplasia, Squamous | 3 1 1 2 3 1 1 2 2 1 2 1 1 1 2 2 2 1 2| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | | Mineralization | 4 2| Thrombosis | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7| DAY ON TEST | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5| | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia | 4 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 2 1 3 3 3| Alveolus, Infiltration Cellular, | | Histiocyte | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 1 2 2 2| Artery, Mediastinum, Mineralization | 3 | Interstitium, Fibrosis | 3 2 2 2 2 3 2 2 2 2 2 2 3 2 3 3 3 2 1 2 2 3| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 2 1 1 3 2| Thrombosis | 2 | Goblet Cell, Lateral Wall, | | Hyperplasia | 3 2 3 2 3 3 3 3 3 3 3 2 3 2 2 3 2 2 3 2 3| Lateral Wall, Hyperplasia | 3 3 3 3 3 3 2 3 3 3 3 3 3 3 2 3 3 3 3 2 3| Lateral Wall, Metaplasia, Squamous | 1 2 2 2 1 4 1 1 3 3 2 3 2 1 2 2 3 3| Olfactory Epithelium, Degeneration, | | Hyaline | 1 4 3 2 3 2 3 3 3 3 3 4 3 3 3 3 3 2 3 3 3 3| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| Cataract | | Degeneration | 3| Retina, Atrophy | | __________________________________________________________________________| Harderian Gland | + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2| Mineralization | 2 2| Nephropathy | 1 3 4 3 2 4 3 2 3 2 4 2 4 3 3 3 2 2 2 3 4 4| Renal Tubule, Hyperplasia | 3 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, | | Polymorphonuclear | 2| _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + | Inflammation, Acute | 2 | Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + A + A + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + | Angiectasis | 1 | Basophilic Focus | X X X X X X X X X | Degeneration, Cystic | 3 1 2 2 2 2 2 2 2 2 | Degeneration, Fatty | 2 3 2 2 1 | Eosinophilic Focus | X X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | 2 | Thrombosis | | Bile Duct, Hyperplasia | 2 1 1 3 1 2 1 2 2 2 3 | Centrilobular, Necrosis | 2 1 | __________________________________________________________________________| Mesentery | + + + + | Fat, Hemorrhage | 3 | Fat, Necrosis | 3 2 | __________________________________________________________________________| Oral Mucosa | + + | Gingival, Hyperplasia, Squamous | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + | Atrophy | 1 3 2 1 2 4 2 2 3 1 2 | Basophilic Focus | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + | Duct, Metaplasia, Squamous | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + | Diverticulum | X | Hyperplasia, Squamous | 3 3 | Necrosis | 3 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 3 3 1 | Necrosis | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + | Aorta, Mineralization | 2 3 | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + | Cardiomyopathy | 2 2 2 2 2 2 1 2 1 3 1 3 3 2 3 2 2 2 2 2 | Artery, Mineralization | 2 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 1 1 2 2 2 2 2 1 2 2 2 2 | Hypertrophy | | Necrosis | | Vacuolization Cytoplasmic | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 2 3 3 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 3 2 2 3 4 3 2 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 4 | Mineralization | | Pars Distalis, Hyperplasia | 3 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | C-Cell, Hyperplasia | 1 1 1 1 1 1 1 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + | Granuloma Sperm | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + | Hyperplasia | 3 1 3 2 | Inflammation, Chronic Active | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + | Atrophy | | Artery, Inflammation, Chronic Active | 3 1 | Interstitial Cell, Hyperplasia | 3 2 1 2 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + | Iliac, Infiltration Cellular, Plasma | | Cell | 2 | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + + + + + M M M M M M + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + M + + + + + | Hemorrhage | 2 | Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + + + + + + + + + + M + + + + + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + | Fibrosis | 2 2 2 2 2 3 2 | Hemorrhage | 3 3 | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + M + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M M + + M M M M + M M + + + M M + M + + | Galactocele | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + | Cyst | 2 | Inflammation, Chronic Active | 3 3 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + | Fibrous Osteodystrophy | 2 3 1 | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 2 2 | Mineralization | 1 | Necrosis | 2 | Meninges, Hyperplasia | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + I + + + + + + + + + + + + + + + + + + + + | Epiglottis, Metaplasia, Squamous | 1 1 1 2 2 1 1 3 2 3 2 1 2 3 2 2 2 3 2 2 | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + | Hemorrhage | 1 2 | Inflammation, Chronic Active | | Inflammation, Suppurative | | Mineralization | 3 2 | Thrombosis | 3 | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 _____________________________________________________________________________________________________________________ | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6| DAY ON TEST | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2| | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia | 1 2 3 2 | Alveolar Epithelium, Metaplasia | 3 2 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2 2 | Artery, Mediastinum, Mineralization | | Interstitium, Fibrosis | 3 1 2 2 3 3 2 2 2 3 2 2 3 3 3 2 3 2 3 3 3 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + A + + + + + + | Inflammation, Suppurative | 3 1 2 2 2 2 3 2 2 2 | Thrombosis | 2 1 | Goblet Cell, Lateral Wall, | | Hyperplasia | 2 3 3 2 3 2 3 3 3 3 3 3 3 3 2 2 1 3 3 2 3 | Lateral Wall, Hyperplasia | 2 2 2 3 3 3 2 2 3 3 3 3 3 3 2 2 3 3 3 3 | Lateral Wall, Metaplasia, Squamous | 3 3 3 3 1 2 3 2 2 2 3 3 3 2 3 3 3 | Olfactory Epithelium, Degeneration, | | Hyaline | 3 3 3 2 3 3 3 2 2 2 3 3 3 2 3 4 3 3 3 3 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + | Mineralization | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 4 | Degeneration | 3 | Retina, Atrophy | 3 | __________________________________________________________________________| Harderian Gland | | Inflammation, Chronic Active | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + | Cyst | 2 | Mineralization | | Nephropathy | 4 3 2 4 4 4 2 2 2 4 3 2 2 3 4 2 4 4 2 3 4 4 | Renal Tubule, Hyperplasia | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + | Infiltration Cellular, | | Polymorphonuclear | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 49 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 49 | Inflammation, Acute | | 1 2.0| Parasite Metazoan | | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 48 | __________________________________________________________________________|____________| Liver | + + + + + + | 50 | Angiectasis | | 3 2.0| Basophilic Focus | X X | 23 | Degeneration, Cystic | 2 3 | 16 2.1| Degeneration, Fatty | | 9 1.8| Eosinophilic Focus | | 5 | Hepatodiaphragmatic Nodule | X | 6 | Mixed Cell Focus | | 1 | Necrosis | 1 | 3 1.3| Thrombosis | | 1 2.0| Bile Duct, Hyperplasia | 2 1 3 3 | 29 2.1| Centrilobular, Necrosis | 2 | 6 1.7| __________________________________________________________________________|____________| Mesentery | | 7 | Fat, Hemorrhage | | 1 3.0| Fat, Necrosis | | 4 2.3| __________________________________________________________________________|____________| Oral Mucosa | + | 4 | Gingival, Hyperplasia, Squamous | | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + | 50 | Atrophy | 2 1 2 3 | 28 2.0| Basophilic Focus | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 50 | Duct, Metaplasia, Squamous | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 50 | Diverticulum | | 1 | Hyperplasia, Squamous | | 2 3.0| Necrosis | 2 | 5 2.6| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 50 | Mineralization | | 6 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 78 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | | 2 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 4 | Aorta, Mineralization | | 4 2.5| __________________________________________________________________________|____________| Heart | + + + + + + | 50 | Cardiomyopathy | 3 1 1 1 3 | 39 1.9| Artery, Mineralization | | 2 2.5| Atrium, Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 50 | Hyperplasia | 2 2 1 | 25 1.7| Hypertrophy | | 1 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | | 4 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 50 | Hyperplasia | 1 1 2 | 15 2.1| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 50 | Hyperplasia | 2 | 3 2.3| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 50 | Hyperplasia | 2 | 12 2.7| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 50 | Hemorrhage | | 1 4.0| Mineralization | | 1 2.0| Pars Distalis, Hyperplasia | 3 | 8 2.9| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 50 | C-Cell, Hyperplasia | 1 2 1 1 1 | 22 1.1| Follicular Cell, Hyperplasia | | 3 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + | 50 | Granuloma Sperm | | 1 2.0| __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 50 | Inflammation, Chronic Active | | 6 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | + + + + + + | 50 | Hyperplasia | | 4 2.3| Inflammation, Chronic Active | 2 2 | 4 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + | 50 | __________________________________________________________________________|____________| Testes | + + + + + + | 50 | Atrophy | | 1 4.0| Artery, Inflammation, Chronic Active | | 3 2.3| Interstitial Cell, Hyperplasia | 2 | 10 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 50 | __________________________________________________________________________|____________| Lymph Node | + + | 13 | Iliac, Infiltration Cellular, Plasma | | | Cell | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M M + | 36 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 47 | Hemorrhage | | 1 2.0| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 49 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + | 47 | __________________________________________________________________________|____________| Spleen | + + + + + + | 50 | Fibrosis | 2 | 13 2.2| Hemorrhage | | 3 3.3| Necrosis | | 2 4.0| __________________________________________________________________________|____________| Thymus | + + M + + + | 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M + + | 26 | Galactocele | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + | 49 | Cyst | | 1 2.0| Inflammation, Chronic Active | 3 | 5 2.6| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 50 | Fibrous Osteodystrophy | | 5 2.2| __________________________________________________________________________|____________| Skeletal Muscle | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 50 | Hemorrhage | | 2 2.0| Mineralization | | 1 1.0| Necrosis | | 1 2.0| Meninges, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | A + I + + + | 47 | Epiglottis, Metaplasia, Squamous | 3 2 1 2 | 43 1.8| __________________________________________________________________________|____________| Lung | + + + + + + | 50 | Hemorrhage | 1 | 3 1.3| Inflammation, Chronic Active | | 1 3.0| Inflammation, Suppurative | 2 | 1 2.0| Mineralization | | 4 2.8| Thrombosis | | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 4 | 6 2.3| Alveolar Epithelium, Metaplasia | 3 2 3 3 3 3 | 50 2.9| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 2 2 2 2 | 49 1.9| Artery, Mediastinum, Mineralization | | 1 3.0| Interstitium, Fibrosis | 2 2 2 3 2 2 | 50 2.4| __________________________________________________________________________|____________| Nose | + + + + + + | 49 | Inflammation, Suppurative | 3 | 18 2.0| Thrombosis | | 3 1.7| Goblet Cell, Lateral Wall, | | | Hyperplasia | 3 3 2 3 3 3 | 48 2.6| Lateral Wall, Hyperplasia | 2 3 3 3 3 3 | 47 2.8| Lateral Wall, Metaplasia, Squamous | 1 1 2 3 3 | 40 2.3| Olfactory Epithelium, Degeneration, | | | Hyaline | 3 3 3 3 3 3 | 49 2.9| __________________________________________________________________________|____________| Trachea | + + + + + + | 50 | Mineralization | | 2 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | Cataract | | 2 3.5| Degeneration | | 2 3.0| Retina, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 88034-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC 30-MONTH OZONE Date: 04/23/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:58 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 4| 7| | | DAY ON TEST | 2| 1| 5| 6| 8| 0| | | | 1| 9| 3| 1| 8| 5| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| | A | 1.0 PPM | 5| 5| 5| 5| 5| 5| | L | | 1| 2| 3| 4| 5| 6| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 50 | Cyst | | 3 2.0| Mineralization | | 2 2.0| Nephropathy | 2 2 3 4 3 3 | 50 3.0| Renal Tubule, Hyperplasia | | 3 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 49 | Infiltration Cellular, | | | Polymorphonuclear | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------