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TDMS Study 88034-05 Pathology Tables

NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  03/24/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Basophilic Focus                     |    X  X  X  X  X  X  X        X     X        X        X  X  X  X  X  X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |    2        2        2     3        3  3  2              3     3        2|             
      Eosinophilic Focus                   |                      X              X                                    |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Mixed Cell Focus                     |                   X     X                 X     X                    X   |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2              2  2        2  2  1  1              2               |             
      Centrilobular, Necrosis              |    3                 1  2        2     3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +  +                       +        +               |             
      Inflammation, Chronic Active         |                                                 3                        |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |    3                 2                                   3               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |       +                                                                  |             
      Gingival, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |       1     2  1     1     2           1                 2               |             
      Basophilic Focus                     |                                                             X            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                2                                         2               |             
      Mineralization                       |                                                                          |             
      Necrosis                             |    3                             3     1  3                 4  2     3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                   1                                      2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2  2     2  1  2     3              1           1  1  1  2  1     2|             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |       2  2                             2  2           2  1               |             
      Hypertrophy                          |          3                                   2                          3|             
      Necrosis                             |             2                                                            |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |    1                 2        3                                3     2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2  1     2     3  2           4                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   2      |             
      Pars Distalis, Hyperplasia           |                         3        2     3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2  2     2  1  2     2  1  1  1  2  2  1     1        2  1  1     1   |             
      Follicular Cell, Hyperplasia         |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +  +  M  +  +|             
      Inflammation, Chronic Active         |                4        3        3        2                              |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                 3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +        +  +                 +  +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Inflammation, Granulomatous   |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +     M  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |       3  2                 3                 2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |    2        2           1        1                       2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +|             
      Cyst                                 |          1                                                               |             
      Hyperkeratosis                       |                                                       3                  |             
      Inflammation, Chronic Active         |    3                 1           4           3                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Fracture                             |                                                                         X|             
      Hyperostosis                         |                         4  4                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3                                                  2   |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                4                                                         |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
      Artery, Infiltration Cellular,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 5| 6| 6| 7| 8| 6| 5| 7| 6| 7| 6| 7| 5| 4| 6| 8| 6| 6| 6| 4| 7| 5|             
                             DAY ON TEST   | 2| 9| 1| 5| 2| 8| 4| 7| 5| 8| 0| 9| 1| 9| 8| 5| 0| 2| 7| 0| 3| 4| 1| 3| 8|             
                                           | 3| 0| 9| 4| 7| 4| 7| 4| 2| 1| 8| 1| 8| 6| 9| 7| 6| 3| 4| 4| 1| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Histiocyte                       |    3                                                                     |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       3                                                                  |             
      Thrombosis                           |                         2        3     4                                2|             
      Lateral Wall, Hyperplasia            |       1                                3                                 |             
      Lateral Wall, Metaplasia, Squamous   |       3                                                              2   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    1  2     1  2  1  2  1  1  2  1  2  1  2  2  1     2  2  2  2  1  2  1|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |    3  3  2  2  1  3  4  2  1  3  2  2  2  3  2  2     3  2  2  2  1  3  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                                        3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     I  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A  +  +  +  +  +  +  +  +     +  +  +  +  +  A     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A  +  +  +  +  +  +  +  +     +  +  +  +  +  A     +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A  +  +  +  +  +  +  +  A     +  +  +  +  +  A     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X  X  X     X  X  X        X  X  X  X  X  X     X     X  X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                   2  1                          1        1        2      |             
      Eosinophilic Focus                   |                                           X                              |             
      Hepatodiaphragmatic Nodule           |                         X                                   X            |             
      Mixed Cell Focus                     |          X  X                                                           X|             
      Necrosis                             |             2                                      2                     |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |       1  1              2           3                    2               |             
      Centrilobular, Necrosis              |                                           1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +              +     +  +     +                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               |                                                    3                     |             
      Fat, Necrosis                        |                      2                    3  2                           |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                              +                           |             
      Gingival, Cyst                       |                                              4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |       1              2     2        2  1        2        2     2  1     2|             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                                                 1                        |             
      Necrosis                             |                      3                       1           2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Acute                  |                      2                                                   |             
      Mineralization                       |                                        1        1  3                     |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Mineralization                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     2  1        2           2  1  2  1  2  3           1  1     2|             
      Artery, Mineralization               |                                                    3                     |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Hyperplasia                          |             3  2        2           2     2     4        2        2  1  2|             
      Hypertrophy                          |             2                                   2                        |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                    3                     |             
      Vacuolization Cytoplasmic            |                         3           2  3                 2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |             2                       3           2                       2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |             3                                      3                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          3  1  2  2  1     2        2  2  3  2  2        2           1  2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     I  +  +  M  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                       +                    +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Hemorrhage                    |             1                                                            |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       M  M  M  +  +  M  M  M  +     +  +  M  M  M  M     +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +  +  +  +  +  +  +  M     +  +  +  +  +  +     +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +  +  I  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +  +  +  M  +  +  +  M  +     +  +  +  M  +  +     +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +  +  I  M  +  +  +     +  M  +  +  +  +     +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Galactocele                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                    4                     |             
      Fracture                             |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |             1                                                            |             
      Necrosis                             |                                           2                              |             
      Thrombosis                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +  +  +  +  +  +  A     +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                              1                           |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               1                                          |             
      Mineralization                       |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                      1                                               1   |             
      Artery, Infiltration Cellular,       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 8| 8| 4| 4| 8| 5| 0| 6| 6| 7| 7| 7| 8| 8| 6| 7| 5| 6| 7| 4| 6|             
                             DAY ON TEST   | 2| 2| 2| 6| 7| 7| 6| 3| 4| 6| 3| 2| 3| 4| 3| 4| 7| 2| 2| 2| 5| 3| 8| 9| 4|             
                                           | 3| 3| 3| 0| 4| 4| 7| 4| 2| 6| 1| 3| 5| 8| 1| 7| 4| 7| 3| 2| 6| 5| 3| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Histiocyte                       |                                                                          |             
      Artery, Mediastinum, Mineralization  |                                                    3                     |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
           Chronic                         |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2  3                    2              2     3                     |             
      Thrombosis                           |                   3                       1                              |             
      Lateral Wall, Hyperplasia            |                               2                                          |             
      Lateral Wall, Metaplasia, Squamous   |             2                 3                    2                     |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1  2  2  2  1  1  2  2        1  1  2  1  2  1     1  1  2  1  1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                         3                                                |             
      Mineralization                       |                                                    3                     |             
      Nephropathy                          |       2  3  4  4  1  2  2  2        3  1  3  3  3  4     2  2  2  2  2  2|             
      Pelvis, Dilatation                   |                         3                                                |             
      Renal Tubule, Hyperplasia            |                                                    1                     |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  48        |
      Parasite Metazoan                    | X                                                                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  48        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  47        |
      Hyperplasia, Adenomatous             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X  X        X                                                            |     37     |
      Clear Cell Focus                     | X                                                                        |      1     |
      Degeneration, Fatty                  |       1  2     3                                                         |     18  2.1|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Mixed Cell Focus                     |    X     X  X                                                            |     11     |
      Necrosis                             |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    3                                                                     |      1  3.0|
      Bile Duct, Hyperplasia               |       2                                                                  |     15  1.8|
      Centrilobular, Necrosis              |       1        2                                                         |      8  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |  11        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Cyst                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  49        |
      Atrophy                              |    4     1  1                                                            |     20  1.7|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |          4                                                               |     11  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  1.7|
      Necrosis                             |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 2  1        1                                                            |     30  1.6|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia                          | 2  2        2                                                            |     19  2.1|
      Hypertrophy                          | 1                                                                        |      6  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      9  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |          2  2                                                            |     12  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |    2                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |          2                                                               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  | 2  1  1  2  2  2                                                         |     37  1.7|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 | 3                                                                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  10        |
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Inflammation, Granulomatous   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  M  +  +                                                         |  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +                                                         |  47        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  42        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |                                                                          |      6  1.7|
      Hematopoietic Cell Proliferation     |             3                                                            |      1  3.0|
      Thrombosis                           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  50        |
      Galactocele                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |             3                                                            |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Fracture                             |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Epiglottis, Metaplasia, Squamous     |    3                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |      4  1.0|
      Artery, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  3.0|
      Artery, Perivascular, Inflammation,  |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |                                                                          |      6  2.5|
      Thrombosis                           |       3        3                                                         |      8  2.6|
      Lateral Wall, Hyperplasia            |                1                                                         |      4  1.8|
      Lateral Wall, Metaplasia, Squamous   |                                                                          |      5  2.4|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  2  1  2  1                                                         |     48  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |             2                                                            |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 3  2  3  3  3  2                                                         |     49  2.4|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 6| 5| 7| 6|                                                        |            |
                             DAY ON TEST   | 7| 5| 7| 7| 5| 9|                                                        |            |
                                           | 4| 9| 8| 7| 8| 1|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |          X           X                                X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Angiectasis                          |                      1     4                                2            |             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X  X  X  X  X  X           X     X  X     X   |             
      Clear Cell Focus                     |                   X  X                                                   |             
      Degeneration, Fatty                  |    1  1  2  2  1              2           2           1  2        3  3   |             
      Eosinophilic Focus                   |                                           X           X                  |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hepatodiaphragmatic Nodule           |                X        X                                                |             
      Inflammation, Granulomatous          |                                        3                                 |             
      Mixed Cell Focus                     |                X                    X                             X      |             
      Bile Duct, Hyperplasia               |       1                                2                 2               |             
      Centrilobular, Necrosis              |                            1  1           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                             +           +     +   |             
      Artery, Inflammation, Chronic Active |                                                                      3   |             
      Artery, Mineralization               |                                                                      2   |             
      Fat, Necrosis                        |                      2                             2           3         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                       +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Atrophy                              |       2     2     2  2        1                       1           1      |             
      Basophilic Focus                     |                                                       X                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Necrosis                             |       3                             3     3                       3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Mineralization                       |                                  2                                   3   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                +                                                         |             
      Hyperplasia                          |                4                                                         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Developmental Malformation           |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                      +   |             
      Aorta, Mineralization                |                                                                      4   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2  2     2  1  1  2  3  1     1  2  2  2  1           2     2     1  3   |             
      Artery, Mineralization               |                                                                      3   |             
      Atrium, Thrombosis                   |                                     3     2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Atrophy                              |       2                                                                  |             
      Hyperplasia                          |    1     2     2  1  2           2     2  2           2     2        2   |             
      Hypertrophy                          |             2                          2     2                           |             
      Necrosis                             |                            2                                             |             
      Thrombosis                           |                                                                      3   |             
      Vacuolization Cytoplasmic            | 2  1                                                              3      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Hyperplasia                          |             2  1     2  2  3        1     1                       2  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +   |             
      Hyperplasia                          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Pars Distalis, Hyperplasia           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      C-Cell, Hyperplasia                  |    1  1  2  1  2  2  2  2  3  2     1  2  2  2                 1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Inflammation, Granulomatous          |                                                    2                     |             
      Thrombosis                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +        +     +                                      +  +   |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |    2                                                                     |             
      Renal, Hemorrhage                    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +     +  +  A  M  +  +  +   |             
      Infiltration Cellular, Plasma Cell   |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     M  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Depletion Cellular                   |                                                                          |             
      Fibrosis                             |       2     3        2                                                   |             
      Hematopoietic Cell Proliferation     |                         3                                            3   |             
      Hemorrhage                           |       3                                                                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                      2                                            4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Fibrous Osteodystrophy               |                                                                      3   |             
      Hyperostosis                         |          2              3                                      3     3   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Epiglottis, Metaplasia, Squamous     |    1  1  1        1  1        1                             1            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Congestion, Chronic                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                           2                              |             
      Mineralization                       |                                                                      3   |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Alveolar Epithelium, Metaplasia      |    2     2  1  2  2  3  2     2  2  2  2  2  2     1  2     1  1  1  2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1     1     1  1  2  1     1  1  1  2  1  1        1     1  1     1   |             
      Artery, Mediastinum, Mineralization  |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 8| 8| 7| 8| 8| 8| 7| 6| 7| 7| 8| 7| 7| 4| 6| 2| 8| 4| 7| 5| 6| 8| 6|             
                             DAY ON TEST   | 3| 9| 0| 4| 5| 2| 7| 7| 7| 9| 3| 9| 4| 3| 6| 6| 2| 8| 7| 5| 1| 7| 3| 0| 2|             
                                           | 6| 8| 3| 2| 6| 4| 4| 4| 5| 1| 9| 3| 2| 3| 7| 8| 3| 7| 4| 2| 0| 9| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Fibrosis               |    1     1  1  1  1  2  2     1  1  1  2  1  1     1  1        1  1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +   |             
      Inflammation, Suppurative            |                                           3                              |             
      Thrombosis                           |       2                    1        3     2                              |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2  1  3  2  2  2  2  2  2  1  2  1  2  1  1     1  3     3  2  2  1   |             
      Lateral Wall, Hyperplasia            | 2  2  3  2  2  2  2  2  2  2  2  2  2  2  3  1     1  2     2  1  2  2   |             
      Lateral Wall, Metaplasia, Squamous   |       1  1              1  1  1     2  1  2           1                  |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  2  2  1  1  2  1  2  2  2  1  2  3  2  1     2  1     2  2  2  2   |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          A           +   |             
      Cornea, Inflammation, Chronic Active |                                                                      3   |             
      Cornea, Mineralization               |                                                                      3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +   |             
      Mineralization                       |                                                                      2   |             
      Nephropathy                          | 2  2  2  3     4  3  3  2  2  2  3  3  1  4  1        4     2  3  2  4   |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Hyperplasia            |          1                                                               |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Parasite Metazoan                    |                X                                X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Parasite Metazoan                    |       X                          X                          X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
      Inflammation, Acute                  |                                     3                                    |             
      Necrosis                             |                                     3                                    |             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  A     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Angiectasis                          | 3  2                             2                       1               |             
      Basophilic Focus                     | X  X  X     X  X     X  X  X  X  X  X  X     X  X  X     X  X     X      |             
      Clear Cell Focus                     |          X                                               X               |             
      Degeneration, Fatty                  | 1     3     2           3  2              1  2                 2  1     2|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X        X              X  X                                             |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |          X                       X                 X                     |             
      Bile Duct, Hyperplasia               |             1        2     3        1  1  2  2                           |             
      Centrilobular, Necrosis              |             2                                                  2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +           +              +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        |                                              2           3              3|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Atrophy                              |             1                                      2     1     1  3      |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Necrosis                             |          4                 4                       3                    3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                3        3|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Cardiomyopathy                       |    1  2  2  2  2     1        1     1  3     2     2     1  1  2  2      |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |       3                                                        3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Atrophy                              |                            2        2                                    |             
      Hyperplasia                          | 2     2  2     2     2  2        1     2     2     1        2     1      |             
      Hypertrophy                          |                                                             2            |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |       2                                                                  |             
      Vacuolization Cytoplasmic            |          2           2        2                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia                          |          2           2     2  2     3  2                    1  3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +     +  +  +  +     +|             
      Hyperplasia                          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Pars Distalis, Hyperplasia           |                                                 2                       3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      C-Cell, Hyperplasia                  |       2  1  1  2     1     2     1  2  1  2  2  2  1     1  3  1        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Chronic Active         |             2                                3                 1         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Cyst                                 |                      4                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Thrombosis                           |                                              2                           |             
      Endometrium, Hyperplasia             |                               4                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Granulomatous          |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +  +              +                             +|             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  M     +  +  +  +  +  +  M  +  M  +  M     +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +     M  +  +  +     +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  M  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Depletion Cellular                   |                                                                4         |             
      Fibrosis                             |       2     1        2                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                         3|             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Chronic Active         |       1                                3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Fibrous Osteodystrophy               |                      3                             2                     |             
      Hyperostosis                         |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Hemorrhage                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +     +  +  +  +  +  +  +  +  +  I  +     +  +  +  +     +|             
      Epiglottis, Metaplasia, Squamous     | 1           1        2           1     1     1     1        1     1      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Congestion, Chronic                  |       3                                                                  |             
      Hemorrhage                           |                                                 1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1                 2                                   1         |             
      Alveolar Epithelium, Metaplasia      | 1     1  2  1  2     1  1  2  2  2  2  2  1  2  1  2     2  1  2  1     1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1        1     1     1  1  1  1  1  1  1  1  1  1  1     1  1  1        1|             
      Artery, Mediastinum, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 6| 8| 7| 8| 6| 7| 7| 6| 7| 5| 7| 8| 5| 8| 5| 8| 6| 7| 8| 6| 8| 6| 5|             
                             DAY ON TEST   | 2| 3| 7| 5| 3| 3| 2| 2| 7| 8| 5| 1| 7| 1| 7| 3| 0| 4| 2| 2| 7| 9| 1| 2| 8|             
                                           | 7| 8| 8| 9| 3| 8| 3| 3| 5| 2| 6| 3| 8| 7| 1| 0| 9| 9| 3| 1| 4| 9| 0| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Fibrosis               | 1     1  1     1     1  1  1  2  2  1  2  1  2  1  2     2  1  1        1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Inflammation, Suppurative            |       1     2                       2           2                       2|             
      Thrombosis                           |                         2  2                                   4         |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2  2  1  2  2        1  1  2  2  1  1  2  2  2  2     2  2     2     1|             
      Lateral Wall, Hyperplasia            | 2  1  2  2  2  2     1  2  2  2  2  2  2  2  1  2  2     2  2  2  2     2|             
      Lateral Wall, Metaplasia, Squamous   | 1     2  1  1  2           2  2  1              1  1           1        3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  2  2  2  2  2     2  1  2  2  1  3  2  2  2  1  2     2  3  1  1     2|             
      Olfactory Epithelium, Metaplasia     |             2                       2           2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  2  2  4  2  2     4  2  2  2  1  2  3  2  4  1  4     2  3  2  4     1|             
      Pelvis, Dilatation                   |                                              2                           |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +  +                                                         |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Parasite Metazoan                    |                X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      7  2.1|
      Basophilic Focus                     | X        X     X                                                         |     39     |
      Clear Cell Focus                     |                X                                                         |      5     |
      Degeneration, Fatty                  |          3                                                               |     22  1.9|
      Eosinophilic Focus                   |          X                                                               |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      7     |
      Inflammation, Granulomatous          |                2                                                         |      2  2.5|
      Mixed Cell Focus                     |       X        X                                                         |      8     |
      Bile Duct, Hyperplasia               |       1  2                                                               |     12  1.7|
      Centrilobular, Necrosis              |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +  +                                                         |  49        |
      Atrophy                              | 1              2                                                         |     14  1.6|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +  +                                                         |  50        |
      Necrosis                             |          3                                                               |      9  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 2           2  2                                                         |     35  1.7|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +  +  +                                                         |  49        |
      Atrophy                              |                                                                          |      3  2.0|
      Hyperplasia                          | 3              2                                                         |     25  1.8|
      Hypertrophy                          |             3                                                            |      5  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +  +  +                                                         |  49        |
      Hyperplasia                          |                2                                                         |     18  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +  +                                                         |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +  +  +                                                         |  48        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +                                                         |  49        |
      Pars Distalis, Hyperplasia           |          3  3                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +                                                         |  49        |
      C-Cell, Hyperplasia                  |       1  2  2  2                                                         |     38  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +  +  +  +                                                         |  48        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |          1  3                                                            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +                                                         |  50        |
      Thrombosis                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +                                                         |  49        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |  12        |
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +  +  +  +                                                         |  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +  +  +                                                         |  44        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     M  +  +  +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +  +                                                         |  50        |
      Depletion Cellular                   |                                                                          |      1  4.0|
      Fibrosis                             |                                                                          |      6  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +  +  +                                                         |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |       4                                                                  |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      3  2.7|
      Hyperostosis                         |          4                                                               |      6  3.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +  +  +                                                         |  47        |
      Epiglottis, Metaplasia, Squamous     |                                                                          |     16  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +  +  +                                                         |  50        |
      Congestion, Chronic                  |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      5  1.4|
      Alveolar Epithelium, Metaplasia      | 1     2     2  2                                                         |     44  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1     1     1  1                                                         |     38  1.1|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  4.0|
      Interstitium, Fibrosis               | 1     1     1  1                                                         |     41  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +  +                                                         |  49        |
      Inflammation, Suppurative            |             2                                                            |      7  2.0|
      Thrombosis                           |                                                                          |      7  2.3|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 2     1  1  2  3                                                         |     47  1.8|
      Lateral Wall, Hyperplasia            | 2     1  2  2  2                                                         |     49  1.9|
      Lateral Wall, Metaplasia, Squamous   | 1        1  1  1                                                         |     25  1.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2        2  2  2                                                         |     48  1.8|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Cornea, Mineralization               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          | 2     2  2  2  4                                                         |     47  2.5|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 6| 5| 6| 8| 8|                                                        |            |
                             DAY ON TEST   | 1| 2| 8| 1| 7| 7|                                                        |            |
                                           | 7| 3| 0| 6| 4| 4|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +  +                                                         |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X        X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X  X                             X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                         1            |             
      Basophilic Focus                     | X  X  X        X  X  X        X  X  X  X  X  X  X  X  X  X  X     X  X  X|             
      Clear Cell Focus                     |                                                                   X      |             
      Degeneration, Cystic                 |                   3              2        2                       3      |             
      Degeneration, Fatty                  |          2  3     2  1           1        2     2                        |             
      Eosinophilic Focus                   | X                                                           X            |             
      Hepatodiaphragmatic Nodule           | X                 X  X           X        X                 X  X        X|             
      Mixed Cell Focus                     |             X                                X        X                 X|             
      Necrosis                             |                1                                      2        1         |             
      Bile Duct, Hyperplasia               | 2  2              1                    2           1  1           2      |             
      Centrilobular, Necrosis              |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                    +         |             
      Fat, Necrosis                        |                                           2                    2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2              1     1  1                    2        2     1  2  2      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                  3                                       |             
      Necrosis                             |          3  4        3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   3                 1     2                              |             
      Necrosis                             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Aorta, Mineralization                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1  2  1  2  1  1     1  1  1     1  2     1  2  1  1        2  2|             
      Artery, Mineralization               |                   3                                                      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          |    1  3              2        1  2        2  1  1  1     2        2     2|             
      Hypertrophy                          |          1  2  2                                                  2      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                2  2     1        2           2                          2|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  2     1  2              2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +     +  +  M  +  +  +  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |       2           4                                                      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           | 3  2                                   2           3     2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1        1  1  4  1  1     1        1     2  1  2              1     2|             
      Follicular Cell, Hyperplasia         |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                         2|             
      Inflammation, Chronic Active         |                                           1                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Granulomatous          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +                             +                          +      |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  M  M  M  M  +     +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2                                               2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             3           2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       2           3                                                      |             
      Hyperostosis                         |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                                         3|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     | 1  2  1  1  2  2  3  3  1     3  3  2  2  1  2  1  2  2  3     2  2  2  2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                   4                                                      |             
      Alveolar Epithelium, Hyperplasia     |          3                                                               |             
      Alveolar Epithelium, Metaplasia      | 3  3  3  4  3  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  3  3  2  3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  2  3  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Artery, Mediastinum, Mineralization  |                   4                                                      |             
      Interstitium, Fibrosis               | 2  2  3  3  2  2  3  3  3     2  3  3  2  3  3  2  3  3  2  3  3  2  2  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2        1                                2           1     2  2      |             
      Thrombosis                           |                                                                2         |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 3  2  2  3  2  3  2  2  3     3  2  2  2  3  3  2  3  2  2  3  2  2  2  2|             
      Lateral Wall, Hyperplasia            | 3  3  2  3  2  3  3  3  3     3  2  3  3  3  3  3  3  3  3  3  3  3  3  2|             
      Lateral Wall, Metaplasia, Squamous   | 2  3  1  2  1  2  2  1  1     2  1        2     1     2  3     1  2  1  1|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 4  4  3  3  4  3  3  3  3     3  3  3  2  3  1  3  3  4  4  4  3  3  3  3|             
      Olfactory Epithelium, Metaplasia     |    1                                         2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 8| 5| 8| 8| 8| 6| 6| 6| 7| 8| 6| 4| 8| 7| 5| 6| 6| 7| 6| 8| 8| 6| 7|             
                             DAY ON TEST   | 5| 8| 6| 8| 1| 7| 7| 6| 6| 2| 5| 3| 4| 8| 7| 3| 5| 7| 7| 4| 8| 4| 7| 9| 3|             
                                           | 4| 2| 1| 0| 1| 4| 4| 3| 6| 3| 8| 1| 3| 6| 4| 3| 9| 0| 0| 4| 5| 8| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Cataract                             |                                                                          |             
      Degeneration                         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   2                                                      |             
      Nephropathy                          | 1  2  4  2  3  4  4  1  2     3  4  3     4  3  2  1  2  1  2  1  3  2  3|             
      Thrombosis                           |       2                                                                  |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Hyperplasia            |                   1                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +     +  I  +  +     +  +  +  I  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                         X           X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Parasite Metazoan                    |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     A  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X        X     X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X   |             
      Clear Cell Focus                     |          X              X                       X                    X   |             
      Degeneration, Cystic                 |                                                                2         |             
      Degeneration, Fatty                  | 3           2                             2                              |             
      Eosinophilic Focus                   |                         X                 X                              |             
      Hepatodiaphragmatic Nodule           | X  X                 X     X                                             |             
      Mixed Cell Focus                     |                         X              X     X                 X         |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |             1        2                    2                              |             
      Centrilobular, Necrosis              | 2                    1                    1        1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                            +   |             
      Fat, Necrosis                        |                         3                                            2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Atrophy                              | 1           2        1              1     2  1  2     2     1        2   |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia, Squamous                |          3                                                  3            |             
      Necrosis                             | 4                                         1        2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Mineralization                       |             1                                                            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Cardiomyopathy                       |             1        1  2        2  2  2  1  1  2     1     2  2     1   |             
      Artery, Mineralization               |                                                                          |             
      Atrium, Thrombosis                   |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                             3            |             
      Hyperplasia                          |    2                 1  2           1     1  2  2     2        2  1      |             
      Hypertrophy                          |          3                                                               |             
      Necrosis                             |          2                                                               |             
      Vacuolization Cytoplasmic            |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                         2  2     2        3     2           2  2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +     +  +  +  +     +  +  +  M  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Cyst                                 |          1                 1                                             |             
      Pars Distalis, Hyperplasia           |    2                 2           2  2                                   2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1     1  1              1  1  1  1  1  1  1     2     1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +     +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                    +                                       |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +  +     +  +  M  +     +  M  M  M  +  +  M  M     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M     M  +     +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     M  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     M  +     +  +  +  +     M  +  +  +  +  +  +  +     M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Fibrosis                             |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                             3           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +     +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Galactocele                          |          3        3                                                  3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Gliosis                              |                                                                          |             
      Mineralization                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     | 1  2     3  2     2  1  3  4     2  3  2  1  2  1  2  4     1  3  2     1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Chronic Active         |                            4                    1                        |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              3                           |             
      Alveolar Epithelium, Metaplasia      | 2  3     4  2     3  3  3  3     3  3  3  3  3  3  3  3     3  3  2  3  2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  2     3  2     3  2  2        2  2  2  2  2  2  2  2     2  2  2  2  1|             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Interstitium, Fibrosis               | 2  2     4  2     2  2  3  2     2  3  3  3  2  3  2  3     3  2  1  3  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2        3     3                        |             
      Thrombosis                           | 3                          3                                             |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  2     1  3     2  2  3  2     3  3  3  2  2  2  3  3     2  2  3  3  2|             
      Lateral Wall, Hyperplasia            | 3  3     2  3     2  3  3  3     3  2  2  3  3  3  3  3     3  2  3  3  3|             
      Lateral Wall, Metaplasia, Squamous   | 1  2     2  1        2     2     1  2           2  1  1     1  1        1|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 4  4     2  3     4  3  3  3     4  4  3  3  3  3  4  4     3  4  3  4  3|             
      Olfactory Epithelium, Metaplasia     |                                           2     3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 6| 6| 7| 8| 7| 6| 8| 7| 7| 7| 7| 8| 6| 6| 6| 8| 8| 4| 6| 2|             
                             DAY ON TEST   | 3| 0| 2| 3| 0| 2| 1| 9| 7| 5| 2| 0| 1| 7| 2| 6| 7| 7| 9| 2| 1| 7| 8| 3| 8|             
                                           | 5| 5| 3| 6| 5| 3| 4| 3| 4| 3| 3| 0| 4| 5| 1| 1| 4| 3| 5| 3| 7| 4| 3| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cataract                             |                                                 2                        |             
      Degeneration                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1     4  2     2  2  3  3     2  2  3  2  3  3  2  2     1  3  1  2  1|             
      Thrombosis                           |                                                                          |             
      Pelvis, Inflammation, Acute          |          3                                                               |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +                                                         |  47        |
      Parasite Metazoan                    |          X                                                               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +                                                         |  50        |
      Angiectasis                          |          3                                                               |      3  2.0|
      Basophilic Focus                     |       X  X  X  X                                                         |     42     |
      Clear Cell Focus                     |                                                                          |      5     |
      Degeneration, Cystic                 |                                                                          |      5  2.4|
      Degeneration, Fatty                  |    3                                                                     |     11  2.1|
      Eosinophilic Focus                   |                                                                          |      4     |
      Hepatodiaphragmatic Nodule           |                                                                          |     12     |
      Mixed Cell Focus                     |       X                                                                  |      9     |
      Necrosis                             |                                                                          |      3  1.3|
      Bile Duct, Hyperplasia               |                                                                          |     10  1.6|
      Centrilobular, Necrosis              |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +                                                         |  50        |
      Atrophy                              |    1  2                                                                  |     21  1.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +                                                         |  50        |
      Basophilic Focus                     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +                                                         |  50        |
      Hyperplasia, Squamous                |                                                                          |      3  3.0|
      Necrosis                             |       3                                                                  |      7  2.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      4  1.8|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       |    1  1  1     1                                                         |     35  1.4|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |     22  1.6|
      Hypertrophy                          |          1                                                               |      6  1.8|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2                                                                  |      8  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |    1                                                                     |     13  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M  +  +  +                                                         |  44        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      2  1.0|
      Pars Distalis, Hyperplasia           |                                                                          |     10  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  |    3  1  1  1                                                            |     30  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M  +  +  +  +                                                         |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +                                                               |   9        |
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +  M  +  +                                                         |  34        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  M  +  +  +                                                         |  46        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +  +  +  +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +                                                         |  50        |
      Fibrosis                             |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +                                                         |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +                                                         |  50        |
      Galactocele                          |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
      Hyperostosis                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +                                                         |  50        |
      Gliosis                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  +  +                                                         |  50        |
      Epiglottis, Metaplasia, Squamous     |    1  3  1  1  2                                                         |     48  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Mineralization                       |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
      Alveolar Epithelium, Metaplasia      |    3  3  3  3  3                                                         |     50  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 4| 5|                                                        |            |
                             DAY ON TEST   | 2| 5| 1| 7| 6| 6|                                                        |            |
                                           | 3| 1| 3| 5| 7| 6|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2  2  2  1  2                                                         |     49  2.0|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  4.0|
      Interstitium, Fibrosis               |    3  2  3  2  2                                                         |     50  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +                                                         |  50        |
      Inflammation, Suppurative            |    1                                                                     |     10  1.9|
      Thrombosis                           |                                                                          |      3  2.7|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |    2  3  3  3  3                                                         |     50  2.4|
      Lateral Wall, Hyperplasia            |    3  3  3  3  3                                                         |     50  2.8|
      Lateral Wall, Metaplasia, Squamous   |    2           2                                                         |     35  1.6|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |    3  4  3  3  3                                                         |     50  3.2|
      Olfactory Epithelium, Metaplasia     |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          |    2  3  4  2  2                                                         |     49  2.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |             2                             3     3                 2  2   |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                              X        X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                 2                 2  2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |          1                                      2                        |             
      Basophilic Focus                     | X        X  X     X  X        X     X     X  X  X     X           X  X   |             
      Clear Cell Focus                     |       X                                                                  |             
      Degeneration, Cystic                 |       2           1  2  2     2           2     3           2        2   |             
      Degeneration, Fatty                  |    2        1              2           2  2     2                    1   |             
      Eosinophilic Focus                   |                               X                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Mixed Cell Focus                     |                   X                                                      |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  2  2     3  1  2  1  2  3  3     2     1  1  3  3     3     2     4|             
      Centrilobular, Necrosis              |                         3  2     1     2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +  +  +           +  +  +                 +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               |                                           4  3  3                 3  3   |             
      Fat, Necrosis                        |       1                    2  2                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              | 3        2     3     2  2  2     2     2  2        1  4     3     1  2   |             
      Hyperplasia                          |                                     2     2                              |             
      Thrombosis                           |                                     2                                    |             
      Artery, Inflammation                 |                                     4                                    |             
      Artery, Mineralization               |                                              3                       2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Artery, Mineralization               |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                     2     3  4  2                 3  2   |             
      Necrosis                             | 2  2              3        1           3              4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                         2     3  3  3     4  4  3                 4  3   |             
      Necrosis                             | 3                          2                          1                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +     +  +  +                 +  +   |             
      Aorta, Mineralization                |                                     3     4  4  4                 4  4   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 2     1  2  1     1     3  1  2  1  3  2  3  3  3  1  3  1  3     3  3  3|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization               |                                     2     3  4                    4  3   |             
      Atrium, Thrombosis                   |                3           4  2                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 1  2                 2     2  2     2     2  1                    2  2   |             
      Hypertrophy                          |    2  2                 1        1              1                        |             
      Vacuolization Cytoplasmic            | 2                                      2              3           2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 1        2        2  2  3     2  2     2  1        2     1           2  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                   3                                         3            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                         2     4  3  4     4  4  4                 4  4   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                              2                           |             
      Thrombosis                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       2              2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |    1  1  2  3  1  2  1  1  1        1     1  2  1  2        2     1      |             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Granuloma Sperm                      |       2           3                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                  +      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |          1                                2  2                           |             
      Inflammation, Chronic Active         |       3                          2                    3     2     4  2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Mineralization                       |                                           3     3                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |       4  4     3        2                 3                 4     4      |             
      Artery, Inflammation, Chronic Active |                   2                 2        3                           |             
      Artery, Mineralization               |                                                                   3      |             
      Interstitial Cell, Hyperplasia       |    1           2  1  2     1     1                          1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +           +     +  +  +        +  +     +     +  +   |             
      Renal, Hemorrhage                    |       2           2                 2     2                       2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +     M  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Infiltration Cellular, Plasma Cell   |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Ectasia                              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                3  3        3  3                       2     3     3      |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +     +  M  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia, Atypical                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |             4                          3  3                              |             
      Inflammation, Chronic Active         |          3                                   4           3           3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrous Osteodystrophy               |                   1     2     3     3     4  3  3                 3  3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                                 3                 2  2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion, Chronic                  |                                                                          |             
      Hemorrhage                           |                                     3                                    |             
      Inflammation, Chronic Active         |                         1                                                |             
      Mineralization                       |                                     2     3  4  4                 2  3   |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia     |                      2  4                                                |             
      Artery, Mediastinum, Mineralization  |                                           4  3  4                 4  4   |             
      Artery, Mediastinum, Thrombosis      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Suppurative            |                               4  3        2  1  2  2              3  3   |             
      Thrombosis                           |                2           4     3                                1  2   |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                 1                        |             
      Lateral Wall, Hyperplasia            |                            2     2     1  1     2  1                     |             
      Lateral Wall, Metaplasia, Squamous   |                            2  4  2              4                 2  3   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  2  2  2  1  1  2  2  2  1  1  2  2  1  2  1  2  1  1  2        2  2|             
      Olfactory Epithelium, Metaplasia     |                               1  1  1  3                          3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                              2                       3   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                               2              3                       3   |             
      Hyperplasia, Oncocytic               |                                                                          |             
      Mineralization                       |                         2           2     4  3  4                 4  3   |             
      Nephropathy                          | 3  4  3  3  3  3  4  3  4  2  4  4  4  4  4  4  4  3  4  2  2     4  4  4|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                       2                  |             
      Renal Tubule, Hyperplasia            |             1                 3  1           2                           |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                        1                          2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 7| 6| 6| 6| 5| 6| 6| 8| 6| 5| 7| 7| 6| 6| 5| 6| 4| 7| 6| 6| 6| 5|             
                             DAY ON TEST   | 1| 8| 9| 0| 6| 2| 7| 8| 2| 6| 3| 6| 8| 0| 9| 7| 6| 9| 6| 8| 2| 2| 6| 3| 8|             
                                           | 0| 5| 1| 5| 3| 1| 4| 0| 5| 3| 0| 9| 6| 8| 7| 4| 3| 1| 1| 5| 2| 3| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                   2      |             
      Transitional Epithelium, Hyperplasia |       2                                                           3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Inflammation, Acute                  |                                                    3                     |             
      Mineralization                       |    2                             2                                       |             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     A  +  +|             
      Inflammation, Acute                  |                                                    2                     |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X        X                       X  X     X     X        X     X|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 2  1     2                             2        2                        |             
      Degeneration, Fatty                  |    1  2  2        1  1                       3     3                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |       X                                               X                  |             
      Mixed Cell Focus                     |                                     X                                    |             
      Necrosis                             |             1                                                            |             
      Thrombosis                           |                                                       2                  |             
      Vacuolization Cytoplasmic, Focal     |                                                          2               |             
      Bile Duct, Hyperplasia               | 1  3        3              3     4  2  2  1     3  2  2  3  1     1  3  1|             
      Centrilobular, Necrosis              |          1                       1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                   +  +  +     +           +      |             
      Inflammation, Chronic Active         |                                           2                              |             
      Artery, Mineralization               |       2                                                                  |             
      Fat, Necrosis                        |                                              3        3           2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              | 3     2     3        2           3  1  2     2  3     1              2   |             
      Hyperplasia                          |                   2                                                      |             
      Thrombosis                           |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |       2                                                                  |             
      Necrosis                             |                                     2        4     2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |       3                             3     3        3                     |             
      Necrosis                             |                   2                          3              2            |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                             +              +                     |             
      Aorta, Mineralization                |       3                             4              4                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       | 1  2  3  2  2     1  2     2        3  2  3  2  2     3  2  2     2      |             
      Mineralization                       |                                     2                                    |             
      Artery, Mineralization               |       3                             3              3                     |             
      Atrium, Thrombosis                   |          3                 3     2                 3                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                                                    3                     |             
      Hyperplasia                          |    1  2     2                                2     2  2  1              2|             
      Hypertrophy                          |                                                 1                        |             
      Vacuolization Cytoplasmic            |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          | 4                 4  1                 3        2        2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  M     +  +  +|             
      Hyperplasia                          |       3              2              3     4        4                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                   3      |             
      Pars Distalis, Hyperplasia           |       2                          3              1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      C-Cell, Hyperplasia                  |       1     2     1  4              2  3        1           1        1  1|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                           +                              |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                 +   |             
      Inflammation, Acute                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |          3                       2           3     3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hyperplasia                          |       3                          3                 2                     |             
      Inflammation, Chronic Active         |                                              3           2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Atrophy                              |                                     1                                    |             
      Artery, Inflammation, Chronic Active |                                     3                                    |             
      Artery, Mineralization               |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                        1     1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +  +                    +              +               |             
      Renal, Hemorrhage                    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +     M  M     +     +  M  +  +  +  +  M  +  M  +     +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Infiltration Cellular, Plasma Cell   | 3                                                                       2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +     M  +     +     +  +  +  +  +  +  +  +  +  M     +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |             2     2        2     3              4     2  3               |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +     +     M  +  M  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +     +  M     +     +  +  +  +  +  M  +  M  M  M     M  M  M|             
      Galactocele                          |    2              2                    3                                 |             
      Hyperplasia, Atypical                |                                        2                                 |             
      Inflammation, Chronic Active         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrosis                             |                                              3                           |             
      Hyperkeratosis                       |                      2                                                   |             
      Inflammation, Chronic Active         |    2  2     4     3  4                 3  3        3  3  2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibrous Osteodystrophy               |    1  3           2                 4     3        3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pigmentation, Hemosiderin            |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |       2                                            3                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Congestion, Chronic                  |                                                       4                  |             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Chronic Active         | 1                                                  2                     |             
      Mineralization                       |    2  3                             2              2                     |             
      Necrosis                             |                                                    3                     |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2        1                                                   |             
      Artery, Mediastinum, Mineralization  |       3                                            4                     |             
      Artery, Mediastinum, Thrombosis      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation, Suppurative            |    2  2                             3     3        2                     |             
      Thrombosis                           |          3  2              4     3              1                    1   |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Lateral Wall, Hyperplasia            |    2        1              2                          1                  |             
      Lateral Wall, Metaplasia, Squamous   |    3                                               3                     |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1  1  1  1     2  1     2     2  1  1  1  2  2  1  2  2  1     1  2  2|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mineralization                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Degeneration                         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Oncocytic               |                                                    2                     |             
      Mineralization                       |       2                             3              2                     |             
      Nephropathy                          | 3  4  4  2  3     4  3     3     3  4  4  4  4  3  4  4  2  2     2  2  3|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Renal Tubule, Hyperplasia            |       3              1                                                   |             
      Renal Tubule, Hyperplasia, Oncocytic |       3                                                                  |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 6| 6| 6| 6| 5| 6| 7| 5| 5| 6| 5| 6| 7| 6| 7| 4| 6| 5| 4| 4|             
                             DAY ON TEST   | 6| 9| 6| 7| 3| 2| 8| 8| 2| 8| 2| 1| 8| 9| 0| 9| 1| 6| 5| 0| 8| 2| 3| 8| 6|             
                                           | 8| 1| 1| 0| 3| 3| 3| 1| 3| 3| 3| 8| 0| 8| 0| 9| 5| 6| 1| 5| 4| 3| 9| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                              3                           |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +                                                         |  49        |
      Mineralization                       |                                                                          |      5  2.4|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +                                                         |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +                                                         |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +                                                         |  50        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                X                                                         |     23     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                2                                                         |     15  1.9|
      Degeneration, Fatty                  |                                                                          |     14  1.8|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Mixed Cell Focus                     |       X                                                                  |      3     |
      Necrosis                             |                                                                          |      1  1.0|
      Thrombosis                           |                1                                                         |      2  1.5|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 3  3  2        3                                                         |     39  2.2|
      Centrilobular, Necrosis              |       2                                                                  |      7  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  16        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      6  3.0|
      Fat, Necrosis                        |          2                                                               |      8  2.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +                                                         |  50        |
      Atrophy                              | 2     2        2                                                         |     28  2.2|
      Hyperplasia                          |                                                                          |      3  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Artery, Inflammation                 |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Artery, Mineralization               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +                                                         |  50        |
      Mineralization                       |                                                                          |      7  2.6|
      Necrosis                             |                                                                          |      9  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +                                                         |  50        |
      Mineralization                       |                                                                          |     13  3.2|
      Necrosis                             |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   9        |
      Aorta, Mineralization                |                                                                          |      9  3.8|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +                                                         |  50        |
      Cardiomyopathy                       |    2           3                                                         |     40  2.2|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Mineralization               |                                                                          |      8  3.1|
      Atrium, Thrombosis                   |                                                                          |      7  2.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +     +                                                         |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |     18  1.8|
      Hypertrophy                          | 1                                                                        |      7  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +     +                                                         |  50        |
      Hyperplasia                          | 3     2                                                                  |     21  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +                                                         |  50        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +                                                         |  49        |
      Hyperplasia                          |          2                                                               |     15  3.4|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |    3  3                                                                  |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +                                                         |  50        |
      C-Cell, Hyperplasia                  |       1  1                                                               |     28  1.5|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +                                                         |  50        |
      Granuloma Sperm                      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +                                                         |  50        |
      Hyperplasia                          |                                                                          |      6  2.2|
      Inflammation, Chronic Active         | 1     4                                                                  |     10  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +                                                         |  50        |
      Atrophy                              |          2                                                               |      9  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      4  2.5|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |       2                                                                  |     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +                                                         |  20        |
      Renal, Hemorrhage                    |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     M                                                         |  36        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +                                                         |  48        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +                                                         |  49        |
      Ectasia                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +     +                                                         |  45        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +                                                         |  50        |
      Fibrosis                             | 2              3                                                         |     16  2.7|
      Hemorrhage                           |          4                                                               |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +                                                         |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +     +                                                         |  31        |
      Galactocele                          |          3                                                               |      4  2.5|
      Hyperplasia, Atypical                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +                                                         |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      4  3.0|
      Inflammation, Chronic Active         | 3        3                                                               |     16  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |     15  2.7|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +                                                         |  50        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     +                                                         |  50        |
      Mineralization                       |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +                                                         |  50        |
      Congestion, Chronic                  |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Mineralization                       |                                                                          |     10  2.7|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.3|
      Artery, Mediastinum, Mineralization  |                                                                          |      7  3.7|
      Artery, Mediastinum, Thrombosis      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +                                                         |  50        |
      Inflammation, Suppurative            |    2                                                                     |     14  2.4|
      Thrombosis                           |                                                                          |     11  2.4|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  1.0|
      Lateral Wall, Hyperplasia            |                                                                          |     10  1.5|
      Lateral Wall, Metaplasia, Squamous   |       1        1                                                         |     10  2.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  1  2  2     2                                                         |     49  1.6|
      Olfactory Epithelium, Metaplasia     |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 5| 6| 7|                                                        |            |
                             DAY ON TEST   | 3| 2| 4| 8| 2| 9|                                                        |            |
                                           | 6| 1| 4| 0| 3| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0|                                                        |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8|                                                        |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +                                                         |  50        |
      Cyst                                 |                                                                          |      3  2.7|
      Hyperplasia, Oncocytic               |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |     10  2.9|
      Nephropathy                          | 3  2  2  2     2                                                         |     50  3.2|
      Pelvis, Dilatation                   |       2                                                                  |      1  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      6  1.8|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +                                                         |  50        |
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Parasite Metazoan                    |                                        X              X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |       3                                                                  |             
      Parasite Metazoan                    |                         X                                                |             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                               1                    2                     |             
      Basophilic Focus                     | X  X     X  X     X           X        X           X                 X   |             
      Degeneration, Cystic                 | 2        2                          4                    2     2         |             
      Degeneration, Fatty                  |             2  1  2  2  2        3        2                          2   |             
      Eosinophilic Focus                   |    X                                                                     |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mixed Cell Focus                     |    X                                               X                     |             
      Necrosis                             |          2  3                 2                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               | 2  4  1  3        1  1  1  2  2     3  2  2  1     2  1  3     3         |             
      Centrilobular, Necrosis              |                                        2  2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +     +  +           +                          +     +     +  +  +   |             
      Artery, Inflammation, Chronic Active | 4                                                                        |             
      Artery, Mineralization               | 3                                                  3                     |             
      Fat, Necrosis                        |    2     2  2           2                                      3     2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |    2     1        1     2  1  1        2  1  3  3  2     2  1  4         |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                   2  2                                               2   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Diverticulum                         |                X                                                         |             
      Hyperplasia, Squamous                | 3                                                                        |             
      Mineralization                       |                      1              2                                    |             
      Necrosis                             |                   4  3           4                                   2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       | 3                                   4              3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                   +              +                     |             
      Aorta, Mineralization                | 4                                   1              3                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy                       | 2  2  2  2  1  2  2  3  1  3  2  2  3  2  1  1  2  3  2  2  2  2     2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Mineralization               | 3                 1  1                             3                     |             
      Atrium, Thrombosis                   | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |                                              3                           |             
      Hyperplasia                          | 2        1        2  2              2     2     1     1  2           1   |             
      Hypertrophy                          |                               2                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |             1                       2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |          2  1     2        2     1     3  1     1     3              2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |          2        3                                            2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          | 4  2                 2              4              4                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |             
      Thrombosis                           |       4                                                                  |             
      Pars Distalis, Hyperplasia           |                                           4     2                 3      |             
      Pars Distalis, Necrosis              |                                                                4         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |    1     1  1  1        1     1  1     2  1     1     1  2     1         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 +        +               |             
      Inflammation, Acute                  |                                                 3        3               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +   |             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic Active         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              | 3                                   4        3                           |             
      Artery, Inflammation, Chronic Active | 3           2        2                                                   |             
      Interstitial Cell, Hyperplasia       |                      1  1                                            1   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +              +              +     +                       +         |             
      Lumbar, Hemorrhage                   |                                  1                                       |             
      Renal, Hemorrhage                    |                   2                                                      |             
      Renal, Pigmentation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  +  M  +  +  +  M  M  +  +  M  +  +  M  +  +  M   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +   |             
      Hemorrhage                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemorrhage                           |                                  1                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrosis                             | 2                                   3                    3               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                           3                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  I  +  M  M  M  M  +  +  +  +  M  +  M  +  M  M  M  +  +  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                        1     4                           |             
      Prepuce, Inflammation, Acute         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Fibrous Osteodystrophy               | 3                 1                 3              2                     |             
      Hyperostosis                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                                    2                     |             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mineralization                       |                                     1                                    |             
      Epiglottis, Metaplasia, Squamous     | 1        1  1  1  1  1     1     1        1                 1     1      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Congestion, Chronic                  |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 3                                   1              3                     |             
      Alveolar Epithelium, Hyperplasia     |                               2                       1                  |             
      Alveolar Epithelium, Metaplasia      | 2  2     1  2  2  2  2  2  3  2  2  2  1  2  2  2  2  2     1  2  1  1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2        1  1  1  1  1  1  1  2  1  1  1  1  1     1        1     1   |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Interstitium, Fibrosis               | 2  1     1  2  2  2  2  2  2  2  2  1  1  2  1  2  2  1     1  2  1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Suppurative            | 2                                   2  2     1     2           2  1      |             
      Thrombosis                           |                                           2                    1         |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  1  1  2  2  1  1  1  2  2  1     1  2  1  1  1  2  2  2  2  2  1  1   |             
      Lateral Wall, Hyperplasia            | 2  2  1  2  2  1  2  2  2  1  3  2  1  3  2  1  1  2  1  3  2  3  2  1   |             
      Lateral Wall, Metaplasia, Squamous   | 3  2     2  2        1  1              1  3        3     2     1  1      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  1  2  2  2  2  2  2  2  2  2  1  1  2  2  1  1  1  1  1  1  2  1   |             
      Olfactory Epithelium, Metaplasia     |                                                                2         |             
                                            __________________________________________________________________________|             
   Pleura                                  |             +                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                 +                                 |             
      Cataract                             |                                        3                                 |             
      Degeneration                         |                      3                                                   |             
      Retina, Atrophy                      |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 | 2                                                                        |             
      Mineralization                       | 2                                   2              3                     |             
      Nephropathy                          | 4  4  1  3  3  3  4  4  4  3  3  4  4  2  3  2  2  4  2  3  2  4  1  4   |             
      Renal Tubule, Hyperplasia            | 2  2                 2                                                   |             
      Renal Tubule, Hyperplasia, Oncocytic |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 7| 6| 4| 6| 6| 6| 5| 7| 5| 7| 5| 6| 3| 4| 7| 5| 6| 5| 6| 3| 6| 6|             
                             DAY ON TEST   | 5| 5| 0| 0| 4| 1| 2| 3| 0| 8| 1| 1| 7| 2| 7| 8| 3| 3| 2| 6| 7| 0| 4| 0| 2|             
                                           | 5| 0| 1| 5| 8| 9| 3| 6| 5| 6| 9| 5| 5| 1| 4| 4| 9| 3| 5| 6| 1| 1| 5| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |       X                       X        X                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Angiectasis                          |                2  3              2                                       |             
      Basophilic Focus                     | X           X  X  X           X        X                 X  X            |             
      Degeneration, Cystic                 | 3              2  2                    3              2     2            |             
      Degeneration, Fatty                  | 3                                                           3           3|             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Infiltration Cellular, Mixed Cell    |                      3                                                   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                      3                                                   |             
      Vacuolization Cytoplasmic, Focal     |                1                                                  3      |             
      Bile Duct, Hyperplasia               |       1  3  1  1     2     1  2  1     2  2     3  1  1  1  2     2     2|             
      Centrilobular, Necrosis              |    4  2  2                    2                 3        2  2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                 +        +        +               |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Mineralization               |                                        3                                 |             
      Fat, Necrosis                        |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Atrophy                              |          3  3        2     1  2  2        2     3     2  2  1     2     2|             
      Basophilic Focus                     |                                        X                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                      4                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  M  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                   3                                               1     4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Acute                  |                                                                   2      |             
      Mineralization                       |                   3                    3           1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                               3                             1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Aorta, Mineralization                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Cardiomyopathy                       | 3     3  2  2  2  3  1        2  2     3        1  1     2  3     2     2|             
      Inflammation, Chronic Active         |    4                                                                     |             
      Artery, Mineralization               |                   2                    2                                 |             
      Atrium, Thrombosis                   | 4                                                           3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 1           1     2  2                 3  1        2        2           1|             
      Hypertrophy                          |    1                                                  2                  |             
      Necrosis                             |                      2                                                   |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hyperplasia                          |                   2  2                    1     2  2              2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hyperplasia                          |          3                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hyperplasia                          |                2  3                    3                    3            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Thrombosis                           |                                                                          |             
      Pars Distalis, Hyperplasia           |       2           1  2                          3                        |             
      Pars Distalis, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      C-Cell, Hyperplasia                  |          2  1  1  1  2     1  1        1  1     1  1  2  2              1|             
      Follicular Cell, Hyperplasia         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                                  +            |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             2                                   4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mineralization                       |                   1                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Atrophy                              |                      2        4                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +                             +  +     +                       +|             
      Lumbar, Hemorrhage                   |                                                                          |             
      Renal, Hemorrhage                    | 2                                      2                                 |             
      Renal, Pigmentation                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  +     M  +  +     +  +     +  +  +  +  +     M     +|             
      Hemorrhage                           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  M  +     +     +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Hemorrhage                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Fibrosis                             |                                        2              2                  |             
      Hematopoietic Cell Proliferation     |    3                                                                     |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     M  +  +  +  +     +     M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  +  +     M  M  M     M  M     +  M  +  M  +     +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Prepuce, Inflammation, Acute         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Fibrous Osteodystrophy               |                1  3                    2                                 |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +           +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Mineralization                       |                                                                          |             
      Epiglottis, Metaplasia, Squamous     | 1           3  2  1                    1        1  1                    2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Congestion, Chronic                  | 3                                                                        |             
      Foreign Body                         |    X                                                                     |             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Suppurative            |    4                                                                     |             
      Mineralization                       |                   1                    2                    1            |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
      Alveolar Epithelium, Metaplasia      | 2        1  2  2  2  2     2  2  2     2  2     2  2  2  2  1     2     3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2           1  1  1        1  2  2     1  2     1  1  1  1  1     1     1|             
      Artery, Mediastinum, Mineralization  |                                        3                                 |             
      Interstitium, Fibrosis               | 1           2  2  2  2     2  2  2     1  2     2  2  2  2  1     2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Inflammation, Suppurative            |       3                    1           2              2     2            |             
      Thrombosis                           |          3           4        2                             3            |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 1        1  1  1  1  1     1  2  2     2  2     1  2  3  2  1     2     1|             
      Lateral Wall, Hyperplasia            | 2        2  1  1  1  1     1  3  1     2  2     2  3  3  2  2     3     2|             
      Lateral Wall, Metaplasia, Squamous   | 1                             1        1        1  1        3     3     1|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1     1  2  2  2  1  1     2  2  1     2  2     1  2  2  2  2     3     2|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Degeneration                         |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
      Cyst                                 |                2  2                                                      |             
      Mineralization                       |                   1                    2                                 |             
      Nephropathy                          | 4     2  2  4  4  4  2     2  2  2     4  2     3  3  2  2  4     2     3|             
      Renal Tubule, Hyperplasia            | 2                                                                        |             
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +     +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 5| 6| 6| 7| 6| 4| 6| 4| 5| 5| 6| 8| 5| 6| 6| 6| 5| 5| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 8| 1| 1| 4| 2| 1| 8| 3| 2| 9| 4| 3| 2| 4| 2| 2| 2| 0| 8| 8| 3| 2| 9| 2| 0|             
                                           | 1| 9| 6| 2| 1| 9| 4| 3| 3| 5| 8| 1| 3| 7| 4| 3| 8| 8| 1| 1| 5| 3| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.5 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |    X                                                                     |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Parasite Metazoan                    |       X                                                                  |      5     |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  48        |
      Inflammation, Acute                  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          | 2                                                                        |      6  2.0|
      Basophilic Focus                     |    X                                                                     |     18     |
      Degeneration, Cystic                 | 1  2                                                                     |     13  2.2|
      Degeneration, Fatty                  |       3  1                                                               |     13  2.2|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |    X                                                                     |      2     |
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      4  2.5|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               | 2  1  2     2                                                            |     38  1.8|
      Centrilobular, Necrosis              |                1                                                         |     10  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                                                         |  17        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      3  3.0|
      Fat, Necrosis                        |          2     2                                                         |     10  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |             2                                                            |     28  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Diverticulum                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      2  1.5|
      Necrosis                             |    4     3     4                                                         |     10  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |       2                                                                  |      7  2.7|
      Necrosis                             |       1                                                                  |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
      Aorta, Mineralization                |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       |    3  1  2  2  2                                                         |     44  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Artery, Mineralization               |                                                                          |      6  2.0|
      Atrium, Thrombosis                   |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  49        |
      Atrophy                              |             4                                                            |      2  3.5|
      Hyperplasia                          |    2  1        1                                                         |     22  1.6|
      Hypertrophy                          |    2           2                                                         |      5  1.8|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  49        |
      Hyperplasia                          |    2  2        1                                                         |     19  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |    3                                                                     |     10  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +                                                         |  48        |
      Thrombosis                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       2        3                                                         |      9  2.4|
      Pars Distalis, Necrosis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  | 2              1                                                         |     29  1.2|
      Follicular Cell, Hyperplasia         |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   4        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  48        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      5  3.2|
      Artery, Inflammation, Chronic Active |                                                                          |      3  2.3|
      Interstitial Cell, Hyperplasia       |                                                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |  13        |
      Lumbar, Hemorrhage                   |                                                                          |      1  1.0|
      Renal, Hemorrhage                    |    2                                                                     |      4  2.0|
      Renal, Pigmentation                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +                                                         |  37        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  47        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +                                                         |  48        |
      Hemorrhage                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |                2                                                         |      6  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  M                                                         |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  M                                                         |  21        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Prepuce, Inflammation, Acute         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |    1                                                                     |      8  2.0|
      Hyperostosis                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +                                                         |  48        |
      Mineralization                       |                                                                          |      1  1.0|
      Epiglottis, Metaplasia, Squamous     |       2                                                                  |     20  1.3|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Congestion, Chronic                  |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           |          1                                                               |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      6  1.8|
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |      4  1.8|
      Alveolar Epithelium, Metaplasia      | 1  2     2  2  2                                                         |     45  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1     1  1  1                                                         |     38  1.2|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  3.0|
      Interstitium, Fibrosis               | 1  2     2  1  1                                                         |     44  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Suppurative            |             1                                                            |     13  1.8|
      Thrombosis                           |                                                                          |      6  2.5|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 1     2  2  2  1                                                         |     46  1.5|
      Lateral Wall, Hyperplasia            | 2  2  2  2  2  2                                                         |     48  1.9|
      Lateral Wall, Metaplasia, Squamous   |       1  1     1                                                         |     23  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 3| 6| 6|                                                        |            |
                             DAY ON TEST   | 1| 9| 2| 4| 7| 6|                                                        |            |
                                           | 1| 5| 2| 6| 0| 3|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0|                                                        |      A     |
    0.5 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  2  2  2  2                                                         |     49  1.7|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Degeneration                         |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      5  2.0|
      Nephropathy                          | 2  4  3  3  3  3                                                         |     49  2.9|
      Renal Tubule, Hyperplasia            |                                                                          |      4  2.0|
      Renal Tubule, Hyperplasia, Oncocytic |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +     +  +     +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2           3   |             
      Basophilic Focus                     |    X           X  X        X              X  X     X  X  X        X  X  X|             
      Degeneration, Cystic                 |    3     3        1                          2                           |             
      Degeneration, Fatty                  |                         1                          1                 1  3|             
      Eosinophilic Focus                   |                                        X                    X     X      |             
      Hepatodiaphragmatic Nodule           | X                                               X                    X   |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                              1                           |             
      Thrombosis                           |                                           2                              |             
      Bile Duct, Hyperplasia               |    3     3     2  3           2  2  2     2  1        3  2  2     3  2   |             
      Centrilobular, Necrosis              |          2                       2                          1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                    +        +         |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                  2                             2         |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1     2     1  2        2     3     1  2  2     2        2  3        1|             
      Basophilic Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Necrosis                             |                3        4                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1              3                          3|             
      Necrosis                             |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                          +|             
      Aorta, Mineralization                |                                              3                          2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2     2     1           1  2  2  2     2  3     2     1        1  1  3|             
      Artery, Mineralization               |                                              3                           |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                1        2  2  1  2  1           2  2  2|             
      Hypertrophy                          |                                  2                                       |             
      Necrosis                             |                                                                2         |             
      Vacuolization Cytoplasmic            |                                           2           1              2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2     2  1  3           2        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3              2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              4                    2     4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                              2                           |             
      Pars Distalis, Hyperplasia           |                                                 2     3           4  3  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     1     1                          2        1  1  1  1        1  1|             
      Follicular Cell, Hyperplasia         |                                                          2           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         2        3        3              3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        4                                 |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
      Interstitial Cell, Hyperplasia       |    1                    1                 1                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +                                   +        +  +      |             
      Iliac, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +     +     +  +     +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +     +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    2     3        2                       2                          3   |             
      Hemorrhage                           |                                                 4                        |             
      Necrosis                             |                                           4                       4      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +     +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M     M     +  +     +  M  M  +  +  M  +  +  +  +  M  M  M  +  M  +  +|             
      Galactocele                          |                                  3                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                              2                          3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Meninges, Hyperplasia                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     | 3        1     1  2     3  1  1  2  2  1     2  1  1  1  2  2     2  1  2|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                3         |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                              4                          2|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 6| 7| 6| 6| 6| 6| 5| 7| 5| 7| 5| 5| 6| 7| 4| 7| 7| 6| 6| 5| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 2| 0| 2| 1| 3| 2| 6| 5| 3| 3| 3| 5| 5| 5| 1| 0| 3| 1| 1| 8| 6| 6| 5|             
                                           | 2| 6| 3| 5| 3| 4| 2| 3| 9| 4| 6| 7| 9| 7| 0| 1| 9| 1| 7| 8| 6| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia      | 4  3     3     3  3     3  3  2  3  3  3  3  3  3  3  3  3  2  1  3  3  3|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3  2     2     2  2     2  2  2  2  2  2  2  2  2  2  2  3  1  1  2  2  2|             
      Artery, Mediastinum, Mineralization  |                                              3                           |             
      Interstitium, Fibrosis               | 3  2     2     2  2     3  2  2  2  2  2  2  3  2  3  3  3  2  1  2  2  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2                    1        2           1     1  3                 2|             
      Thrombosis                           |                                                       2                  |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      |    3     2     3  2     3  3  3  3  3  3  3  2  3  2  2  3  2  2  3  2  3|             
      Lateral Wall, Hyperplasia            |    3     3     3  3     3  3  2  3  3  3  3  3  3  3  2  3  3  3  3  2  3|             
      Lateral Wall, Metaplasia, Squamous   |    1     2     2  2        1     4  1  1  3  3     2  3  2  1  2  2  3  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  4     3     2  3     2  3  3  3  3  3  4  3  3  3  3  3  2  3  3  3  3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                          |             
      Degeneration                         |                                                                         3|             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Inflammation, Chronic Active         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              2                          2|             
      Mineralization                       |                                              2                          2|             
      Nephropathy                          | 1  3     4     3  2     4  3  2  3  2  4  2  4  3  3  3  2  2  2  3  4  4|             
      Renal Tubule, Hyperplasia            |                                              3                          2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Parasite Metazoan                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
      Inflammation, Acute                  |                            2                                             |             
      Parasite Metazoan                    |             X              X        X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  A  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Angiectasis                          |                                                             1            |             
      Basophilic Focus                     | X        X     X                       X        X     X  X  X     X      |             
      Degeneration, Cystic                 | 3     1     2  2              2  2     2  2     2        2               |             
      Degeneration, Fatty                  | 2                                         3     2           2     1      |             
      Eosinophilic Focus                   | X                                         X                              |             
      Hepatodiaphragmatic Nodule           |                      X        X                                          |             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             |             2                                                            |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2              1  1     3     1  2     1           2  2  2     3      |             
      Centrilobular, Necrosis              |    2                                   1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +           +     +                 +            |             
      Fat, Hemorrhage                      |                                           3                              |             
      Fat, Necrosis                        |                                     3                       2            |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             | +                                                                 +      |             
      Gingival, Hyperplasia, Squamous      |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Atrophy                              | 1  3  2  1                 2     4        2     2     3  1  2            |             
      Basophilic Focus                     |             X                                   X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Diverticulum                         |                                              X                           |             
      Hyperplasia, Squamous                | 3                                               3                        |             
      Necrosis                             |             3  1                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Mineralization                       | 3                                         3     1                        |             
      Necrosis                             |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                         +                              |             
      Aorta, Mineralization                | 2                                         3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Cardiomyopathy                       | 2  2  2  2  2  2  1  2  1  3        1  3  3  2  3  2  2  2  2     2      |             
      Artery, Mineralization               |                                           2                              |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hyperplasia                          | 1  1  2  2     2           2           2           1  2  2  2     2      |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                             1            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hyperplasia                          |                2           3           3        2        2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hyperplasia                          | 3           2              2           3  4     3           2     1      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hemorrhage                           |                                  4                                       |             
      Mineralization                       |                                                                          |             
      Pars Distalis, Hyperplasia           |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      C-Cell, Hyperplasia                  |    1        1  1        1        1              1     1                  |             
      Follicular Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Inflammation, Chronic Active         |                         2                                   2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hyperplasia                          |       3                       1              3     2                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |             3                                            1               |             
      Interstitial Cell, Hyperplasia       |    3  2     1           2     1                          1               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                       +     +     +              +     +     +      |             
      Iliac, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  M  M  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +      |             
      Hemorrhage                           |                      2                                                   |             
      Necrosis                             |                         4                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Fibrosis                             |                            2  2  2        2              2  3     2      |             
      Hemorrhage                           |    3                    3                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +     +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  M  M  M  M  +  M  M  +  +  +  M  M  +  M  +     +      |             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Cyst                                 | 2                                                                        |             
      Inflammation, Chronic Active         | 3                                         3                       1      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Fibrous Osteodystrophy               | 2                                         3     1                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hemorrhage                           |                      2        2                                          |             
      Mineralization                       |                                           1                              |             
      Necrosis                             | 2                                                                        |             
      Meninges, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Epiglottis, Metaplasia, Squamous     | 1     1  1  2  2  1  1  3  2  3  2  1  2  3     2  2  2  3  2     2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Hemorrhage                           |                                  1        2                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 3                                         2                              |             
      Thrombosis                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 6| 5| 6| 7| 4| 3| 5| 7| 7| 5| 6| 7| 8| 7| 8| 7| 6| 6| 7| 6| 7| 6| 6|             
                             DAY ON TEST   | 7| 7| 0| 2| 9| 1| 5| 8| 6| 4| 0| 4| 4| 5| 2| 2| 1| 2| 6| 7| 7| 2| 4| 2| 2|             
                                           | 4| 9| 8| 4| 1| 6| 3| 3| 7| 1| 8| 9| 3| 6| 5| 8| 7| 8| 3| 1| 9| 3| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   1     2        3              2                        |             
      Alveolar Epithelium, Metaplasia      | 3  2  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  1  2     2  2  2     2      |             
      Artery, Mediastinum, Mineralization  |                                                                          |             
      Interstitium, Fibrosis               | 3  1  2  2  3  3  2  2  2  3  2  2  3  3  3  2  3  2  3  3  3     3      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +     +      |             
      Inflammation, Suppurative            | 3  1        2  2           2              2     3  2        2     2      |             
      Thrombosis                           |    2                                               1                     |             
      Goblet Cell, Lateral Wall,           |                                                                          |             
          Hyperplasia                      | 2  3  3  2  3  2  3  3  3  3  3  3  3  3  2     2  1  3  3  2     3      |             
      Lateral Wall, Hyperplasia            |    2  2  2  3  3  3  2  2  3  3  3  3  3  3     2  2  3  3  3     3      |             
      Lateral Wall, Metaplasia, Squamous   | 3  3        3  3  1     2  3  2  2  2  3  3     3  2     3  3     3      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  3  3  2  3  3  3  2  2  2  3  3  3  2  3     4  3  3  3  3     3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Mineralization                       | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +        +                                       |             
      Cataract                             |                         3        4                                       |             
      Degeneration                         |                                  3                                       |             
      Retina, Atrophy                      |                         3                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +      |             
      Cyst                                 |                                           2                              |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  3  2  4  4  4  2  2  2  4  3  2  2  3  4  2  4  4  2  3  4     4      |             
      Renal Tubule, Hyperplasia            |             1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +     +      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          |                                                                          |      3  2.0|
      Basophilic Focus                     |    X           X                                                         |     23     |
      Degeneration, Cystic                 |       2  3                                                               |     16  2.1|
      Degeneration, Fatty                  |                                                                          |      9  1.8|
      Eosinophilic Focus                   |                                                                          |      5     |
      Hepatodiaphragmatic Nodule           | X                                                                        |      6     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                1                                                         |      3  1.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1  3  3                                                               |     29  2.1|
      Centrilobular, Necrosis              |       2                                                                  |      6  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Fat, Hemorrhage                      |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   4        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |       2  1  2  3                                                         |     28  2.0|
      Basophilic Focus                     |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  50        |
      Duct, Metaplasia, Squamous           |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  50        |
      Diverticulum                         |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      2  3.0|
      Necrosis                             | 2                                                                        |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      6  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   4        |
      Aorta, Mineralization                |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  50        |
      Cardiomyopathy                       | 3  1  1  1     3                                                         |     39  1.9|
      Artery, Mineralization               |                                                                          |      2  2.5|
      Atrium, Thrombosis                   |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |    2     2     1                                                         |     25  1.7|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |    1  1        2                                                         |     15  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |             2                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                2                                                         |     12  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       3                                                                  |      8  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  50        |
      C-Cell, Hyperplasia                  | 1  2  1  1     1                                                         |     22  1.1|
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +                                                         |  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +                                                         |  50        |
      Inflammation, Chronic Active         |                                                                          |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +                                                         |  50        |
      Hyperplasia                          |                                                                          |      4  2.3|
      Inflammation, Chronic Active         | 2     2                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +                                                         |  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic Active |                                                                          |      3  2.3|
      Interstitial Cell, Hyperplasia       | 2                                                                        |     10  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +                                                               |  13        |
      Iliac, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  M  +                                                         |  36        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  47        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +                                                         |  47        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |    2                                                                     |     13  2.2|
      Hemorrhage                           |                                                                          |      3  3.3|
      Necrosis                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +                                                         |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  +  +                                                         |  26        |
      Galactocele                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       3                                                                  |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  50        |
      Fibrous Osteodystrophy               |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Meninges, Hyperplasia                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | A  +  I  +  +  +                                                         |  47        |
      Epiglottis, Metaplasia, Squamous     |    3     2  1  2                                                         |     43  1.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  50        |
      Hemorrhage                           |    1                                                                     |      3  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |       2                                                                  |      1  2.0|
      Mineralization                       |                                                                          |      4  2.8|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 2              4                                                         |      6  2.3|
      Alveolar Epithelium, Metaplasia      | 3  2  3  3  3  3                                                         |     50  2.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1  2  2  2  2  2                                                         |     49  1.9|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  3.0|
      Interstitium, Fibrosis               | 2  2  2  3  2  2                                                         |     50  2.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  49        |
      Inflammation, Suppurative            |       3                                                                  |     18  2.0|
      Thrombosis                           |                                                                          |      3  1.7|
      Goblet Cell, Lateral Wall,           |                                                                          |            |
          Hyperplasia                      | 3  3  2  3  3  3                                                         |     48  2.6|
      Lateral Wall, Hyperplasia            | 2  3  3  3  3  3                                                         |     47  2.8|
      Lateral Wall, Metaplasia, Squamous   | 1  1  2  3     3                                                         |     40  2.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 3  3  3  3  3  3                                                         |     49  2.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  50        |
      Mineralization                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      2  3.5|
      Degeneration                         |                                                                          |      2  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 88034-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC 30-MONTH                                      OZONE                                           Date: 04/23/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:16:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 4| 7|                                                        |            |
                             DAY ON TEST   | 2| 1| 5| 6| 8| 0|                                                        |            |
                                           | 1| 9| 3| 1| 8| 5|                                                        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0|                                                        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1|                                                        |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2|                                                        |      A     |
    1.0 PPM                                | 5| 5| 5| 5| 5| 5|                                                        |      L     |
                                           | 1| 2| 3| 4| 5| 6|                                                        |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Nephropathy                          | 2  2  3  4  3  3                                                         |     50  3.0|
      Renal Tubule, Hyperplasia            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  49        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------