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https://ntp.niehs.nih.gov/go/3682

TDMS Study 88034-07 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             OZONE/NNK


NTP Experiment-Test: 88034-07                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          48           48           48           48           48           48           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36           40           36           38           36           41           
    Natural Death                                      4            2            9            4            7            3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            6            3            6            5            4           
  Animals Examined Microscopically                    48           48           48           48           48           48           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (1)                       (1)                                    (1)          
      Mineralization                                   1 (100%)                  1 (100%)                                           
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                                            1 (100%)    
   Intestine Large, Rectum                            (1)                       (1)                                                 
      Mineralization                                                             1 (100%)                                           
   Intestine Large, Cecum                                          (1)                       (1)          (2)          (1)          
      Ulcer                                                                                                1 (50%)      1 (100%)    
   Intestine Small, Ileum                                          (1)                       (1)          (1)          (1)          
      Hyperplasia, Lymphoid                                                                                             1 (100%)    
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (100%)                              
   Liver                                              (26)         (27)         (28)         (36)         (42)         (39)         
      Angiectasis                                                   1 (4%)       3 (11%)      3 (8%)       5 (12%)                  
      Degeneration, Cystic                             5 (19%)      3 (11%)      4 (14%)      8 (22%)     17 (40%)      7 (18%)     
      Hepatodiaphragmatic Nodule                       4 (15%)      2 (7%)       1 (4%)       3 (8%)       5 (12%)      1 (3%)      
      Hyperplasia                                                                                          2 (5%)                   
      Hyperplasia, Focal                               1 (4%)       1 (4%)       1 (4%)                    7 (17%)      4 (10%)     
      Infiltration Cellular, Mixed Cell                1 (4%)                                              1 (2%)                   
      Inflammation                                                                            1 (3%)                                
      Necrosis                                         1 (4%)                                                                       
      Necrosis, Focal                                                            1 (4%)                    3 (7%)       3 (8%)      
      Vacuolization Cytoplasmic                        1 (4%)       4 (15%)      4 (14%)      4 (11%)      2 (5%)       2 (5%)      
      Vacuolization Cytoplasmic, Focal                 1 (4%)       1 (4%)                                 1 (2%)                   
      Bile Duct, Hyperplasia                           1 (4%)       2 (7%)       1 (4%)                    1 (2%)                   
      Centrilobular, Necrosis                                       1 (4%)                                 1 (2%)                   
   Mesentery                                          (8)          (10)         (8)          (11)         (8)          (8)          
      Fat, Necrosis                                    7 (88%)      9 (90%)      5 (63%)      7 (64%)      8 (100%)     6 (75%)     
   Oral Mucosa                                                     (4)          (1)                                                 
      Pharyngeal, Foreign Body                                                   1 (100%)                                           
      Pharyngeal, Hyperplasia, Squamous                             2 (50%)                                                         
   Pancreas                                           (1)                       (1)                                    (1)          
      Artery, Inflammation, Chronic                                                                                     1 (100%)    
   Stomach, Forestomach                               (1)                       (2)          (1)          (2)          (1)          
      Hyperplasia, Squamous                                                                                2 (100%)                 
      Inflammation, Chronic Active                                                            1 (100%)     1 (50%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                   1 (100%)                  1 (50%)                                            
      Ulcer                                                                      1 (50%)                                            
   Stomach, Glandular                                 (1)          (1)          (3)          (1)                       (3)          
      Inflammation, Chronic Active                                                            1 (100%)                              
      Mineralization                                   1 (100%)                  2 (67%)                                            
      Necrosis                                                                   1 (33%)                                1 (33%)     
   Tooth                                                                                     (1)          (1)                       
      Developmental Malformation                                                              1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)                       (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
      Mineralization                                                             1 (100%)                                           
      Aorta, Mineralization                            2 (100%)                                                                     
   Heart                                              (1)          (1)          (1)          (2)          (2)                       
      Cardiomyopathy                                                             1 (100%)                                           
      Fibrosis                                                                                             1 (50%)                  
      Mineralization                                   1 (100%)                                                                     
      Necrosis                                                      1 (100%)                                                        
      Atrium, Thrombosis                                                                                   1 (50%)                  
      Pericardium, Fibrosis                                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (4)          (1)          (3)          (1)                       (4)          
      Angiectasis                                                                1 (33%)                                            
      Vacuolization Cytoplasmic                                                                                         1 (25%)     
   Adrenal Medulla                                    (4)                                                 (1)          (1)          
      Hemorrhage                                       1 (25%)                                                                      
   Parathyroid Gland                                  (2)                       (1)          (1)          (1)                       
      Hyperplasia                                      2 (100%)                  1 (100%)     1 (100%)     1 (100%)                 
   Pituitary Gland                                    (34)         (35)         (29)         (27)         (30)         (34)         
      Pars Distalis, Hemorrhage                                                                            1 (3%)                   
      Pars Distalis, Hyperplasia                       1 (3%)       1 (3%)                                 2 (7%)       2 (6%)      
   Thyroid Gland                                      (3)          (2)          (1)                       (1)          (1)          
      Follicular Cell, Hyperplasia                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (32)         (24)         (30)         (31)         (26)         (32)         
      Inflammation, Chronic                           30 (94%)     24 (100%)    30 (100%)    30 (97%)     26 (100%)    32 (100%)    
   Tissue NOS                                         (1)                       (5)                       (1)                       
      Mediastinum, Inflammation, Chronic Active,                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENERAL BODY SYSTEM - CONT                                                                                                          
           Diffuse                                                               1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (1)                                    (1)                                    
      Granuloma Sperm                                  1 (100%)                                                                     
   Penis                                                           (4)          (3)          (1)          (2)          (5)          
      Calculus Gross Observation                                                 1 (33%)                                            
      Calculus Micro Observation Only                                            1 (33%)      1 (100%)                              
      Edema                                                                                                2 (100%)                 
      Inflammation, Chronic Active                                  2 (50%)                                             2 (40%)     
   Preputial Gland                                    (8)          (6)          (8)          (2)          (3)          (9)          
      Inflammation, Chronic Active                     6 (75%)      2 (33%)      5 (63%)      1 (50%)      3 (100%)     7 (78%)     
      Inflammation, Suppurative                        1 (13%)                                                                      
   Prostate                                                        (2)          (1)          (2)                                    
      Inflammation, Suppurative                                     2 (100%)     1 (100%)     2 (100%)                              
   Testes                                             (20)         (9)          (24)         (25)         (19)         (13)         
      Atrophy                                          6 (30%)      1 (11%)      1 (4%)       5 (20%)      1 (5%)       3 (23%)     
      Necrosis                                                                   1 (4%)                                             
      Interstitial Cell, Hyperplasia                   2 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (9)          (7)          (10)         (10)         (17)         (26)         
      Hyperplasia, Lymphoid                                                      1 (10%)                                            
      Infiltration Cellular, Plasma Cell               1 (11%)                                                                      
      Pigmentation                                                               1 (10%)                                            
      Iliac, Infiltration Cellular, Plasma Cell        1 (11%)                                             1 (6%)                   
      Iliac, Pigmentation                                                                                  1 (6%)                   
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (10%)                               
      Pancreatic, Inflammation, Granulomatous          1 (11%)                                                          1 (4%)      
      Renal, Hemorrhage                                1 (11%)                   1 (10%)      1 (10%)                   3 (12%)     
      Renal, Hyperplasia, Lymphoid                                                            1 (10%)                               
      Renal, Infiltration Cellular, Plasma Cell        4 (44%)      1 (14%)                   1 (10%)      1 (6%)       5 (19%)     
      Renal, Inflammation, Granulomatous               1 (11%)      2 (29%)      1 (10%)                   1 (6%)       1 (4%)      
   Lymph Node, Bronchial                              (38)         (32)         (23)         (26)         (30)         (28)         
      Hemorrhage                                       1 (3%)       1 (3%)       1 (4%)       2 (8%)                                
      Hyperplasia, Lymphoid                            2 (5%)                    1 (4%)                                             
      Necrosis                                                      1 (3%)                                                          
   Lymph Node, Mandibular                             (4)          (8)          (7)          (7)          (15)         (14)         
      Hyperplasia, Lymphoid                                                                                1 (7%)                   
      Infiltration Cellular, Plasma Cell                                         5 (71%)      1 (14%)      1 (7%)       3 (21%)     
      Necrosis                                                                                                          1 (7%)      
   Lymph Node, Mesenteric                             (2)          (8)          (3)          (11)         (8)          (9)          
      Hyperplasia, Lymphoid                                                      1 (33%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Granulomatous                                   1 (13%)                   1 (9%)                                
   Lymph Node, Mediastinal                            (42)         (37)         (43)         (43)         (43)         (45)         
      Fibrosis                                                                                                          1 (2%)      
      Hemorrhage                                       2 (5%)       1 (3%)       3 (7%)       2 (5%)                    2 (4%)      
      Infiltration Cellular, Plasma Cell               2 (5%)       1 (3%)       2 (5%)                    1 (2%)       1 (2%)      
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Necrosis                                                      1 (3%)                                              1 (2%)      
   Spleen                                             (35)         (32)         (33)         (37)         (39)         (39)         
      Accessory Spleen                                 1 (3%)                                 1 (3%)       1 (3%)       4 (10%)     
      Atrophy                                                                                                           1 (3%)      
      Congestion                                       2 (6%)                    2 (6%)       1 (3%)                                
      Fibrosis                                        12 (34%)     14 (44%)      7 (21%)     12 (32%)     13 (33%)     10 (26%)     
      Hematopoietic Cell Proliferation                 1 (3%)       1 (3%)       1 (3%)                    1 (3%)       1 (3%)      
      Hemorrhage                                                    2 (6%)                                                          
      Necrosis                                                      1 (3%)       1 (3%)                    1 (3%)       3 (8%)      
      Capsule, Fibrosis                                                                                    1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (4)          (5)          (2)                       (4)          (5)          
      Galactocele                                      2 (50%)      3 (60%)      2 (100%)                  2 (50%)      4 (80%)     
      Hyperplasia                                      1 (25%)      2 (40%)                                1 (25%)      1 (20%)     
      Inflammation, Chronic                                         1 (20%)                                             1 (20%)     
   Skin                                               (47)         (47)         (48)         (48)         (48)         (47)         
      Hyperkeratosis                                                2 (4%)                    1 (2%)       2 (4%)       3 (6%)      
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                    1 (2%)       1 (2%)       2 (4%)      
      Inflammation, Suppurative                                                  1 (2%)                                 1 (2%)      
      Ulcer                                                         2 (4%)                                              1 (2%)      
      Dermis, Cyst                                                                            1 (2%)       1 (2%)                   
      Prepuce, Inflammation, Suppurative                            1 (2%)       3 (6%)       3 (6%)       2 (4%)       1 (2%)      
      Sebaceous Gland, Hyperplasia                                                            1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                              1 (2%)                   
      Subcutaneous Tissue, Necrosis                                                                        1 (2%)                   
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Chronic          46 (98%)     47 (100%)    48 (100%)    47 (98%)     48 (100%)    47 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                        (2)                                    (1)          
      Hemorrhage                                                                                                        1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (48)         (48)         (48)         (48)         (48)         
      Foreign Body                                     3 (6%)       2 (4%)       2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       4 (8%)       3 (6%)       3 (6%)       6 (13%)                  
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                                             1 (2%)                    1 (2%)                   
   Lung                                               (48)         (48)         (48)         (48)         (48)         (48)         
      Congestion                                       2 (4%)       2 (4%)                    5 (10%)                   3 (6%)      
      Edema                                                                      1 (2%)       3 (6%)       1 (2%)                   
      Fibrosis, Focal                                  2 (4%)       1 (2%)                                              1 (2%)      
      Hemorrhage                                       3 (6%)       2 (4%)       2 (4%)       1 (2%)       3 (6%)       5 (10%)     
      Mineralization                                   4 (8%)                    2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Atypical                   10 (21%)                  12 (25%)     33 (69%)     39 (81%)     
      Alveolar Epithelium, Metaplasia                                           35 (73%)     47 (98%)     45 (94%)                  
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                                1 (2%)                                              1 (2%)      
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       1 (2%)       7 (15%)      9 (19%)     13 (27%)      8 (17%)     
      Bronchus, Inflammation, Suppurative                                        1 (2%)                                             
      Interstitium, Fibrosis                                                    34 (71%)     46 (96%)     45 (94%)                  
      Interstitium, Inflammation, Chronic, Diffuse     3 (6%)       1 (2%)       2 (4%)                                             
      Perivascular, Inflammation, Chronic              1 (2%)                                                                       
      Serosa, Fibrosis                                                                                                  1 (2%)      
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Nose                                               (47)         (48)         (48)         (48)         (46)         (48)         
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)       3 (6%)       3 (6%)       1 (2%)       5 (10%)     
      Thrombosis                                                                              1 (2%)                                
      Goblet Cell, Lateral Wall, Hyperplasia           3 (6%)                   38 (79%)     45 (94%)     42 (91%)      3 (6%)      
      Lateral Wall, Hyperplasia                        5 (11%)      4 (8%)      46 (96%)     48 (100%)    46 (100%)     5 (10%)     
      Nasopharyngeal Duct, Infiltration Cellular,                                                                                   
           Mixed Cell                                                                                                   1 (2%)      
      Olfactory Epithelium, Degeneration, Hyaline     47 (100%)    48 (100%)    47 (98%)     48 (100%)    46 (100%)    45 (94%)     
      Olfactory Epithelium, Metaplasia                 1 (2%)       4 (8%)       1 (2%)       1 (2%)                    2 (4%)      
      Turbinate, Necrosis                                                        1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 88034-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:31  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)                       (1)                       (4)          (1)          
      Cataract                                         3 (100%)                  1 (100%)                  2 (50%)      1 (100%)    
      Hemorrhage                                       1 (33%)                                             1 (25%)                  
      Ciliary Body, Retina, Degeneration               2 (67%)                   1 (100%)                  2 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (27)         (22)         (15)         (20)         (25)         (24)         
      Cyst                                             1 (4%)                    2 (13%)                   1 (4%)                   
      Hydronephrosis                                   1 (4%)                                                                       
      Infarct                                                                                 1 (5%)       1 (4%)       2 (8%)      
      Nephropathy                                     27 (100%)    22 (100%)    14 (93%)     18 (90%)     22 (88%)     22 (92%)     
      Pigmentation, Hemosiderin                                                               1 (5%)                                
   Urinary Bladder                                                 (2)          (2)          (3)          (1)          (1)          
      Calculus Gross Observation                                                 1 (50%)                                            
      Calculus Micro Observation Only                                            1 (50%)                   1 (100%)                 
      Hemorrhage                                                                 1 (50%)      2 (67%)                   1 (100%)    
      Inflammation, Chronic Active                                  1 (50%)                                                         
      Inflammation, Suppurative                                                                                         1 (100%)    
      Transitional Epithelium, Necrosis                                                       1 (33%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
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                             ----------              END OF REPORT             ----------                                           
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