https://ntp.niehs.nih.gov/go/3686

TDMS Study 88034-07 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             OZONE/NNK
NTP Experiment-Test: 88034-07                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32
       Facility:  Battelle Northwest
       Chemical CAS #:  10028-15-6
       Lock Date:  02/17/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          48           48           48           48           48           48           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36           40           36           38           36           41           
    Natural Death                                      4            2            9            4            7            3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            6            3            6            5            4           
  Animals Examined Microscopically                    48           48           48           48           48           48           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Rectum                            (1)                       (1)                                                 
      Polyp Adenomatous                                1 (100%)                                                                     
   Intestine Large, Cecum                                          (1)                       (1)          (2)          (1)          
   Intestine Small, Jejunum                                                                                            (1)          
   Intestine Small, Ileum                                          (1)                       (1)          (1)          (1)          
      Carcinoma                                                     1 (100%)                                                        
   Liver                                              (26)         (27)         (28)         (36)         (42)         (39)         
      Cholangiocarcinoma                               1 (4%)                                                                       
      Hepatocellular Adenoma                                                                                            1 (3%)      
   Mesentery                                          (8)          (10)         (8)          (11)         (8)          (8)          
      Sarcoma                                                                    1 (13%)      2 (18%)                               
      Sarcoma, Metastatic, Tissue NOS                                            1 (13%)                                            
   Oral Mucosa                                                     (4)          (1)                                                 
      Pharyngeal, Squamous Cell Papilloma                           2 (50%)                                                         
   Pancreas                                           (1)                       (1)                                    (1)          
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (1)          (1)          (1)          (2)          (2)                       
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (4)          (1)          (3)          (1)                       (4)          
      Adenoma                                                                    1 (33%)                                            
   Adrenal Medulla                                    (4)                                                 (1)          (1)          
      Pheochromocytoma Malignant                       1 (25%)                                             1 (100%)                 
      Pheochromocytoma Benign                          3 (75%)                                                          1 (100%)    
   Islets, Pancreatic                                 (1)          (5)          (1)                                    (1)          
      Adenoma                                                       2 (40%)                                                         
                                                             Page   2                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont                                                                                                             
      Carcinoma                                        1 (100%)     3 (60%)      1 (100%)                               1 (100%)    
   Pituitary Gland                                    (34)         (35)         (29)         (27)         (30)         (34)         
      Schwannoma Malignant, Metastatic, Tissue NOS                               1 (3%)                                             
      Pars Distalis, Adenoma                          32 (94%)     32 (91%)     28 (97%)     23 (85%)     25 (83%)     31 (91%)     
      Pars Distalis, Carcinoma                         1 (3%)                                                                       
   Thyroid Gland                                      (3)          (2)          (1)                       (1)          (1)          
      Carcinoma                                        1 (33%)      1 (50%)                                                         
      Bilateral, C-Cell, Adenoma                                    1 (50%)                                                         
      C-Cell, Adenoma                                                                                      1 (100%)                 
      C-Cell, Carcinoma                                1 (33%)                                                          1 (100%)    
      Follicular Cell, Adenoma                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Peritoneum                                         (32)         (24)         (30)         (31)         (26)         (32)         
   Tissue NOS                                         (1)                       (5)                       (1)                       
      Sarcoma                                          1 (100%)                  4 (80%)                                            
      Abdominal, Osteosarcoma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (1)                                    (1)                                    
   Preputial Gland                                    (8)          (6)          (8)          (2)          (3)          (9)          
      Adenoma                                          1 (13%)                   1 (13%)                                            
      Carcinoma                                                     2 (33%)                                                         
   Seminal Vesicle                                                                                                     (1)          
   Testes                                             (20)         (9)          (24)         (25)         (19)         (13)         
      Interstitial Cell, Adenoma                      15 (75%)      9 (100%)    20 (83%)     23 (92%)     19 (100%)    12 (92%)     
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                                     (1)                       (1)                                    
   Lymph Node                                         (9)          (7)          (10)         (10)         (17)         (26)         
   Lymph Node, Bronchial                              (38)         (32)         (23)         (26)         (30)         (28)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (3%)                   
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (3%)                   
   Lymph Node, Mandibular                             (4)          (8)          (7)          (7)          (15)         (14)         
   Lymph Node, Mesenteric                             (2)          (8)          (3)          (11)         (8)          (9)          
   Lymph Node, Mediastinal                            (42)         (37)         (43)         (43)         (43)         (45)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (2%)                   
   Spleen                                             (35)         (32)         (33)         (37)         (39)         (39)         
                                                             Page   3                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibroma                                          1 (3%)                                                                       
      Sarcoma                                                       1 (3%)                                                          
   Thymus                                                          (1)          (1)          (3)          (2)          (3)          
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (4)          (5)          (2)                       (4)          (5)          
      Fibroadenoma                                     1 (25%)                                             1 (25%)                  
   Skin                                               (47)         (47)         (48)         (48)         (48)         (47)         
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                  2 (4%)       2 (4%)       4 (8%)       2 (4%)       2 (4%)       2 (4%)      
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                    2 (4%)                   
      Trichoepithelioma                                                                                                 1 (2%)      
      Sebaceous Gland, Adenoma                                                                             1 (2%)       1 (2%)      
      Subcutaneous Tissue, Fibroma                     2 (4%)       4 (9%)       2 (4%)                    1 (2%)       1 (2%)      
      Subcutaneous Tissue, Melanoma Benign                          1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Osteosarcoma                                                                        1 (2%)                   
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma                         3 (6%)       4 (9%)       5 (10%)      5 (10%)      1 (2%)       5 (11%)     
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma, Multiple                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                                                        (2)                                    (1)          
      Cranial Nerve, Schwannoma Malignant                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (48)         (48)         (48)         (48)         (48)         (48)         
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       1 (2%)       2 (4%)      14 (29%)     11 (23%)     
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)       9 (19%)      9 (19%)     
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                              9 (19%)      8 (17%)     
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             2 (4%)                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                                            1 (2%)       1 (2%)      
                                                             Page   4                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma                                                                              2 (4%)       1 (2%)      
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                1 (2%)                   
   Nose                                               (47)         (48)         (48)         (48)         (46)         (48)         
      Respiratory Epithelium, Adenoma                                                                                   1 (2%)      
   Pleura                                                                       (2)                                                 
      Sarcoma, Metastatic, Tissue NOS                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Zymbal's Gland                                                                            (3)          (1)                       
      Carcinoma                                                                               3 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (27)         (22)         (15)         (20)         (25)         (24)         
      Sarcoma, Metastatic, Tissue NOS                  1 (4%)                                                                       
      Transitional Epithelium, Carcinoma                                                                   1 (4%)                   
   Urinary Bladder                                                 (2)          (2)          (3)          (1)          (1)          
      Papilloma                                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(48)        *(48)        *(48)        *(48)        *(48)        *(48)         
      Leukemia Mononuclear                            28 (58%)     25 (52%)     25 (52%)     35 (73%)     40 (83%)     37 (77%)     
      Mesothelioma Malignant                           2 (4%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            48          48          45          47          47          48               
     Total Primary Neoplasms                          105          95          96         100         134         124               
   Total Animals with Benign Neoplasms                 41          40          39          37          37          42               
     Total Benign Neoplasms                            63          58          58          53          75          71               
   Total Animals with Malignant Neoplasms              36          30          34          41          43          40               
     Total Malignant Neoplasms                         42          37          38          47          59          53               
   Total Animals with Metastatic Neoplasms              2                       3                       3           1               
     Total Metastatic Neoplasm                          2                       3                       6           1               
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------