Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/3686

TDMS Study 88034-07 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             OZONE/NNK


NTP Experiment-Test: 88034-07                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/08/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32




       Facility:  Battelle Northwest

       Chemical CAS #:  10028-15-6

       Lock Date:  02/17/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          48           48           48           48           48           48           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                36           40           36           38           36           41           
    Natural Death                                      4            2            9            4            7            3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            6            3            6            5            4           
  Animals Examined Microscopically                    48           48           48           48           48           48           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (1)                       (1)                                                 
      Polyp Adenomatous                                1 (100%)                                                                     
   Intestine Large, Cecum                                          (1)                       (1)          (2)          (1)          
   Intestine Small, Jejunum                                                                                            (1)          
   Intestine Small, Ileum                                          (1)                       (1)          (1)          (1)          
      Carcinoma                                                     1 (100%)                                                        
   Liver                                              (26)         (27)         (28)         (36)         (42)         (39)         
      Cholangiocarcinoma                               1 (4%)                                                                       
      Hepatocellular Adenoma                                                                                            1 (3%)      
   Mesentery                                          (8)          (10)         (8)          (11)         (8)          (8)          
      Sarcoma                                                                    1 (13%)      2 (18%)                               
      Sarcoma, Metastatic, Tissue NOS                                            1 (13%)                                            
   Oral Mucosa                                                     (4)          (1)                                                 
      Pharyngeal, Squamous Cell Papilloma                           2 (50%)                                                         
   Pancreas                                           (1)                       (1)                                    (1)          
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (1)          (1)          (1)          (2)          (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (4)          (1)          (3)          (1)                       (4)          
      Adenoma                                                                    1 (33%)                                            
   Adrenal Medulla                                    (4)                                                 (1)          (1)          
      Pheochromocytoma Malignant                       1 (25%)                                             1 (100%)                 
      Pheochromocytoma Benign                          3 (75%)                                                          1 (100%)    
   Islets, Pancreatic                                 (1)          (5)          (1)                                    (1)          
      Adenoma                                                       2 (40%)                                                         
                                                             Page   2                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Carcinoma                                        1 (100%)     3 (60%)      1 (100%)                               1 (100%)    
   Pituitary Gland                                    (34)         (35)         (29)         (27)         (30)         (34)         
      Schwannoma Malignant, Metastatic, Tissue NOS                               1 (3%)                                             
      Pars Distalis, Adenoma                          32 (94%)     32 (91%)     28 (97%)     23 (85%)     25 (83%)     31 (91%)     
      Pars Distalis, Carcinoma                         1 (3%)                                                                       
   Thyroid Gland                                      (3)          (2)          (1)                       (1)          (1)          
      Carcinoma                                        1 (33%)      1 (50%)                                                         
      Bilateral, C-Cell, Adenoma                                    1 (50%)                                                         
      C-Cell, Adenoma                                                                                      1 (100%)                 
      C-Cell, Carcinoma                                1 (33%)                                                          1 (100%)    
      Follicular Cell, Adenoma                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (32)         (24)         (30)         (31)         (26)         (32)         
   Tissue NOS                                         (1)                       (5)                       (1)                       
      Sarcoma                                          1 (100%)                  4 (80%)                                            
      Abdominal, Osteosarcoma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (1)                                    (1)                                    
   Preputial Gland                                    (8)          (6)          (8)          (2)          (3)          (9)          
      Adenoma                                          1 (13%)                   1 (13%)                                            
      Carcinoma                                                     2 (33%)                                                         
   Seminal Vesicle                                                                                                     (1)          
   Testes                                             (20)         (9)          (24)         (25)         (19)         (13)         
      Interstitial Cell, Adenoma                      15 (75%)      9 (100%)    20 (83%)     23 (92%)     19 (100%)    12 (92%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                                     (1)                       (1)                                    
   Lymph Node                                         (9)          (7)          (10)         (10)         (17)         (26)         
   Lymph Node, Bronchial                              (38)         (32)         (23)         (26)         (30)         (28)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (3%)                   
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (3%)                   
   Lymph Node, Mandibular                             (4)          (8)          (7)          (7)          (15)         (14)         
   Lymph Node, Mesenteric                             (2)          (8)          (3)          (11)         (8)          (9)          
   Lymph Node, Mediastinal                            (42)         (37)         (43)         (43)         (43)         (45)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                            1 (2%)                   
      Squamous Cell Carcinoma, Metastatic, Lung                                                            1 (2%)                   
   Spleen                                             (35)         (32)         (33)         (37)         (39)         (39)         
                                                             Page   3                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibroma                                          1 (3%)                                                                       
      Sarcoma                                                       1 (3%)                                                          
   Thymus                                                          (1)          (1)          (3)          (2)          (3)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (4)          (5)          (2)                       (4)          (5)          
      Fibroadenoma                                     1 (25%)                                             1 (25%)                  
   Skin                                               (47)         (47)         (48)         (48)         (48)         (47)         
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                  2 (4%)       2 (4%)       4 (8%)       2 (4%)       2 (4%)       2 (4%)      
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                    2 (4%)                   
      Trichoepithelioma                                                                                                 1 (2%)      
      Sebaceous Gland, Adenoma                                                                             1 (2%)       1 (2%)      
      Subcutaneous Tissue, Fibroma                     2 (4%)       4 (9%)       2 (4%)                    1 (2%)       1 (2%)      
      Subcutaneous Tissue, Melanoma Benign                          1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Osteosarcoma                                                                        1 (2%)                   
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma                         3 (6%)       4 (9%)       5 (10%)      5 (10%)      1 (2%)       5 (11%)     
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Sarcoma, Multiple                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                                                        (2)                                    (1)          
      Cranial Nerve, Schwannoma Malignant                                        1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (48)         (48)         (48)         (48)         (48)         (48)         
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       1 (2%)       2 (4%)      14 (29%)     11 (23%)     
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)       9 (19%)      9 (19%)     
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                              9 (19%)      8 (17%)     
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             2 (4%)                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                                            1 (2%)       1 (2%)      
                                                             Page   4                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma                                                                              2 (4%)       1 (2%)      
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                1 (2%)                   
   Nose                                               (47)         (48)         (48)         (48)         (46)         (48)         
      Respiratory Epithelium, Adenoma                                                                                   1 (2%)      
   Pleura                                                                       (2)                                                 
      Sarcoma, Metastatic, Tissue NOS                                            1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (3)          (1)                       
      Carcinoma                                                                               3 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (27)         (22)         (15)         (20)         (25)         (24)         
      Sarcoma, Metastatic, Tissue NOS                  1 (4%)                                                                       
      Transitional Epithelium, Carcinoma                                                                   1 (4%)                   
   Urinary Bladder                                                 (2)          (2)          (3)          (1)          (1)          
      Papilloma                                                                               1 (33%)                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(48)        *(48)        *(48)        *(48)        *(48)        *(48)         
      Leukemia Mononuclear                            28 (58%)     25 (52%)     25 (52%)     35 (73%)     40 (83%)     37 (77%)     
      Mesothelioma Malignant                           2 (4%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 88034-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             OZONE/NNK                                         Date: 05/08/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 23:01:32  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     TRIOCT./     .1MG/KG      TRIOCT./     .1M/KNNK     1M/K NNK     1 MG/KG         
                                                   AIR          NNK/AIR      OZONE        /OZONE       /OZONE       NNK/AIR         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          45          47          47          48               
     Total Primary Neoplasms                          105          95          96         100         134         124               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          40          39          37          37          42               
     Total Benign Neoplasms                            63          58          58          53          75          71               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          30          34          41          43          40               
     Total Malignant Neoplasms                         42          37          38          47          59          53               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       3                       3           1               
     Total Metastatic Neoplasm                          2                       3                       6           1               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------