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TDMS Study 88034-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                        OZONE/NNK                                       DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 07                                                                                     TIME: 23:08:51       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95262          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034C       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 10028-15-6      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                        OZONE/NNK                                       DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 07                                                                                     TIME: 23:08:51       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95262          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034C       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 10028-15-6      


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                        OZONE/NNK                                       DATE: 05/08/95       
EXPERIMENT: 88034 TEST: 07                                                                                     TIME: 23:08:51       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-95262          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 88034C       
PATHOLOGIST: P. MELLICK                                                                                        CAS: 10028-15-6      


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF 6  OZONE/NNK
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Papilloma Squamous or Papilloma
                                            Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
              Testes                        Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
              ====================================================================================================
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   1
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma Benign                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  3/4 (75%)    0/0 (0%)     0/1 (0%)     1/1 (100%)   |
|ADJUSTED (b)           |  14.7%         0.0%         0.0%         6.3%        |
|TERMINAL (d)           |  0/0          0/0          0/0          0/0          |
|FIRST INCIDENCE (DAYS) |   611          ---          ---          677         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.282N     P=0.167N     P=0.020N*    P=0.443N     |
|INCIDENTAL TUMOR       |  P=0.500N       (e)        P=0.500N       (e)        |
|LOGISTIC REGRESSION    |  P=0.500N       (e)        P=0.500N       (e)        |
|COCHRAN-ARMITAGE       |  P=0.715N                                            |
|FISHER EXACT           |               P=1.000N     P=0.400N     P=0.800      |
|==============================================================================|
|                                                                              |
|Adrenal Medulla                                                               |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                        |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  4/4 (100%)   0/0 (0%)     1/1 (100%)   1/1 (100%)   |
|ADJUSTED (b)           |  16.7%         0.0%         1.2%         6.3%        |
|TERMINAL (d)           |  0/0          0/0          0/0          0/0          |
|FIRST INCIDENCE (DAYS) |   540          ---          610          677         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.188N     P=0.095N     P=0.020N*    P=0.289N     |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)        |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)        |
|COCHRAN-ARMITAGE       |    (e)                                               |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   2
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  0/8 (0%)     2/6 (33%)    0/13 (0%)    0/9 (0%)     |
|ADJUSTED (b)           |   0.0%         8.7%         0.0%         0.0%        |
|TERMINAL (d)           |  0/1 (0%)     0/0          0/1 (0%)     0/1 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          466          ---          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.192N     P=0.212        (e)          (e)        |
|INCIDENTAL TUMOR       |  P=0.193N     P=0.314        (e)          (e)        |
|LOGISTIC REGRESSION    |  P=0.193N     P=0.151        (e)          (e)        |
|COCHRAN-ARMITAGE       |  P=0.195N                                            |
|FISHER EXACT           |               P=0.165        (e)          (e)        |
|==============================================================================|
|                                                                              |
|Clitoral/Preputial Gland                                                      |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  1/8 (13%)    2/6 (33%)    1/13 (8%)    0/9 (0%)     |
|ADJUSTED (b)           | 100.0%         8.7%         0.8%         0.0%        |
|TERMINAL (d)           |  1/1 (100%)   0/0          0/1 (0%)     0/1 (0%)     |
|FIRST INCIDENCE (DAYS) |   736 (T)      466          487          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.116N     P=0.212      P=0.653N     P=0.500N     |
|INCIDENTAL TUMOR       |  P=0.090N     P=0.314      P=0.593N     P=0.500N     |
|LOGISTIC REGRESSION    |  P=0.120N     P=0.395      P=0.679N     P=0.500N     |
|COCHRAN-ARMITAGE       |  P=0.119N                                            |
|FISHER EXACT           |               P=0.385      P=0.629N     P=0.471N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   3
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Islets, Pancreatic                                                            |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  0/1 (0%)     2/5 (40%)    0/1 (0%)     0/1 (0%)     |
|ADJUSTED (b)           |   0.0%        13.7%         0.0%         0.0%        |
|TERMINAL (d)           |  0/0          0/0          0/0          0/0          |
|FIRST INCIDENCE (DAYS) |   ---          557          ---          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.210N     P=0.214        (e)          (e)        |
|INCIDENTAL TUMOR       |  P=0.489N     P=0.500        (e)          (e)        |
|LOGISTIC REGRESSION    |  P=0.447N     P=0.828        (e)          (e)        |
|COCHRAN-ARMITAGE       |  P=0.449N                                            |
|FISHER EXACT           |               P=0.667        (e)          (e)        |
|==============================================================================|
|                                                                              |
|Islets, Pancreatic                                                            |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  1/1 (100%)   3/5 (60%)    1/1 (100%)   1/1 (100%)   |
|ADJUSTED (b)           |   2.2%        18.3%         3.4%        12.5%        |
|TERMINAL (d)           |  0/0          0/0          0/0          0/0          |
|FIRST INCIDENCE (DAYS) |   484          551          704          695         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.323N     P=0.256      P=0.537N     P=0.680      |
|INCIDENTAL TUMOR       |  P=0.489      P=0.500        (e)          (e)        |
|LOGISTIC REGRESSION    |  P=0.447      P=0.828N       (e)          (e)        |
|COCHRAN-ARMITAGE       |  P=0.449                                             |
|FISHER EXACT           |               P=0.667N     P=1.000N     P=1.000N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   4
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Islets, Pancreatic                                                            |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  1/1 (100%)   5/5 (100%)   1/1 (100%)   1/1 (100%)   |
|ADJUSTED (b)           |   2.2%        29.4%         3.4%        12.5%        |
|TERMINAL (d)           |  0/0          0/0          0/0          0/0          |
|FIRST INCIDENCE (DAYS) |   484          551          704          695         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.140N     P=0.080      P=0.537N     P=0.680      |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)        |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)        |
|COCHRAN-ARMITAGE       |    (e)                                               |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N     |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Adenoma                                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  3/48 (6%)    2/48 (4%)   27/144 (19%) 20/48 (42%)   |
|ADJUSTED (b)           |  37.5%         7.7%        57.7%        91.7%        |
|TERMINAL (d)           |  3/8 (38%)    0/6 (0%)     5/14 (36%)   3/4 (75%)    |
|FIRST INCIDENCE (DAYS) |   736 (T)      625          557          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P<0.001 **   P=0.597N     P=0.009 **   P<0.001 **   |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.560N     P=0.013 *    P<0.001 **   |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.591N     P=0.017 *    P<0.001 **   |
|COCHRAN-ARMITAGE       |  P<0.001 **                                          |
|FISHER EXACT           |               P=0.500N     P=0.027 *    P<0.001 **   |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   5
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Carcinoma                                           |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  1/48 (2%)    0/48 (0%)   11/144 (8%)   8/48 (17%)   |
|ADJUSTED (b)           |  12.5%         0.0%        37.4%        62.4%        |
|TERMINAL (d)           |  1/8 (13%)    0/6 (0%)     4/14 (29%)   1/4 (25%)    |
|FIRST INCIDENCE (DAYS) |   736 (T)      ---          640          603         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P<0.001 **   P=0.557N     P=0.064      P=0.003 **   |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.557N     P=0.083      P=0.007 **   |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.557N     P=0.094      P=0.004 **   |
|COCHRAN-ARMITAGE       |  P<0.001 **                                          |
|FISHER EXACT           |               P=0.500N     P=0.150      P=0.015 *    |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma           |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  3/48 (6%)    2/48 (4%)   32/144 (22%) 23/48 (48%)   |
|ADJUSTED (b)           |  37.5%         7.7%        68.6%        93.2%        |
|TERMINAL (d)           |  3/8 (38%)    0/6 (0%)     7/14 (50%)   3/4 (75%)    |
|FIRST INCIDENCE (DAYS) |   736 (T)      625          557          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P<0.001 **   P=0.597N     P=0.002 **   P<0.001 **   |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.560N     P=0.003 **   P<0.001 **   |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.591N     P=0.004 **   P<0.001 **   |
|COCHRAN-ARMITAGE       |  P<0.001 **                                          |
|FISHER EXACT           |               P=0.500N     P=0.008 **   P<0.001 **   |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   6
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Lung                                                                          |
|     Squamous Cell Carcinoma                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    0/48 (0%)    2/144 (1%)   1/48 (2%)    |
|ADJUSTED (b)           |   0.0%         0.0%         8.1%         2.9%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     1/14 (7%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          ---          582          583         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.176        (e)        P=0.423      P=0.489      |
|INCIDENTAL TUMOR       |  P=0.176        (e)        P=0.440      P=0.511      |
|LOGISTIC REGRESSION    |  P=0.206        (e)        P=0.477      P=0.517      |
|COCHRAN-ARMITAGE       |  P=0.211                                             |
|FISHER EXACT           |                 (e)        P=0.562      P=0.500      |
|==============================================================================|
|                                                                              |
|Mesentery                                                                     |
|     Sarcoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    0/48 (0%)    3/144 (2%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         3.4%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          ---          567          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.497        (e)        P=0.347        (e)        |
|INCIDENTAL TUMOR       |  P=0.541        (e)        P=0.392        (e)        |
|LOGISTIC REGRESSION    |  P=0.542        (e)        P=0.379        (e)        |
|COCHRAN-ARMITAGE       |  P=0.536                                             |
|FISHER EXACT           |                 (e)        P=0.420        (e)        |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   7
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                    |
|     Papilloma Squamous or Papilloma                                          |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  1/48 (2%)    3/48 (6%)    0/144 (0%)   0/48 (0%)    |
|ADJUSTED (b)           |   6.3%        16.1%         0.0%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   698          635          ---          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.048N*    P=0.221      P=0.356N     P=0.665N     |
|INCIDENTAL TUMOR       |  P=0.030N*    P=0.243      P=0.290N     P=0.512N     |
|LOGISTIC REGRESSION    |  P=0.039N*    P=0.261      P=0.321N     P=0.570N     |
|COCHRAN-ARMITAGE       |  P=0.033N*                                           |
|FISHER EXACT           |               P=0.308      P=0.250N     P=0.500N     |
|==============================================================================|
|                                                                              |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                    |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  1/48 (2%)    3/48 (6%)    0/144 (0%)   0/48 (0%)    |
|ADJUSTED (b)           |   6.3%        16.1%         0.0%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   698          635          ---          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.048N*    P=0.221      P=0.356N     P=0.665N     |
|INCIDENTAL TUMOR       |  P=0.030N*    P=0.243      P=0.290N     P=0.512N     |
|LOGISTIC REGRESSION    |  P=0.039N*    P=0.261      P=0.321N     P=0.570N     |
|COCHRAN-ARMITAGE       |  P=0.033N*                                           |
|FISHER EXACT           |               P=0.308      P=0.250N     P=0.500N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   8
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Oral Mucosa                                                                   |
|     Squamous Cell Papilloma                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    2/48 (4%)    0/144 (0%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%        10.6%         0.0%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          635          ---          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.199N     P=0.196        (e)          (e)        |
|INCIDENTAL TUMOR       |  P=0.176N     P=0.222        (e)          (e)        |
|LOGISTIC REGRESSION    |  P=0.191N     P=0.220        (e)          (e)        |
|COCHRAN-ARMITAGE       |  P=0.181N                                            |
|FISHER EXACT           |               P=0.247        (e)          (e)        |
|==============================================================================|
|                                                                              |
|Pituitary Gland: Pars Distalis or Unspecified Site                            |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            | 32/34 (94%)  32/35 (91%)  76/86 (88%)  31/34 (91%)   |
|ADJUSTED (b)           |  94.2%       100.0%        97.0%       100.0%        |
|TERMINAL (d)           |  4/5 (80%)    4/4 (100%)   7/8 (88%)    3/3 (100%)   |
|FIRST INCIDENCE (DAYS) |   484          444          389          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.284      P=0.272      P=0.522N     P=0.170      |
|INCIDENTAL TUMOR       |  P=0.440N     P=0.459N     P=0.294N     P=0.507N     |
|LOGISTIC REGRESSION    |  P=0.418N     P=0.469N     P=0.309N     P=0.471N     |
|COCHRAN-ARMITAGE       |  P=0.389N                                            |
|FISHER EXACT           |               P=0.514N     P=0.282N     P=0.500N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE   9
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Pituitary Gland: Pars Distalis or Unspecified Site                            |
|     Carcinoma or Adenoma                                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            | 33/34 (97%)  32/35 (91%)  76/86 (88%)  31/34 (91%)   |
|ADJUSTED (b)           |  94.4%       100.0%        97.0%       100.0%        |
|TERMINAL (d)           |  4/5 (80%)    4/4 (100%)   7/8 (88%)    3/3 (100%)   |
|FIRST INCIDENCE (DAYS) |   484          444          389          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.320      P=0.317      P=0.457N     P=0.204      |
|INCIDENTAL TUMOR       |  P=0.320N     P=0.257N     P=0.142N     P=0.320N     |
|LOGISTIC REGRESSION    |  P=0.295N     P=0.258N     P=0.148N     P=0.266N     |
|COCHRAN-ARMITAGE       |  P=0.271N                                            |
|FISHER EXACT           |               P=0.318N     P=0.125N     P=0.307N     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal    |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoep|thelioma
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  3/48 (6%)    4/48 (8%)   12/144 (8%)   3/48 (6%)    |
|ADJUSTED (b)           |  25.4%        35.4%        15.8%        28.9%        |
|TERMINAL (d)           |  1/8 (13%)    1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   681          544          416          678         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.424      P=0.361      P=0.318      P=0.393      |
|INCIDENTAL TUMOR       |  P=0.503N     P=0.423      P=0.465      P=0.589      |
|LOGISTIC REGRESSION    |  P=0.549N     P=0.396      P=0.454      P=0.484      |
|COCHRAN-ARMITAGE       |  P=0.532N                                            |
|FISHER EXACT           |               P=0.500      P=0.456      P=0.661N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  10
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Fibroma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/48 (4%)    4/48 (8%)    3/144 (2%)   1/48 (2%)    |
|ADJUSTED (b)           |  18.0%        20.9%         6.1%         2.1%        |
|TERMINAL (d)           |  1/8 (13%)    0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   698          417          529          450         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.190N     P=0.249      P=0.519N     P=0.669N     |
|INCIDENTAL TUMOR       |  P=0.111N     P=0.313      P=0.433N     P=0.507N     |
|LOGISTIC REGRESSION    |  P=0.122N     P=0.314      P=0.443N     P=0.501N     |
|COCHRAN-ARMITAGE       |  P=0.121N                                            |
|FISHER EXACT           |               P=0.339      P=0.367N     P=0.500N     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocyt|ma
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  5/48 (10%)   8/48 (17%)  15/144 (10%)  6/48 (13%)   |
|ADJUSTED (b)           |  29.8%        50.5%        32.9%        37.9%        |
|TERMINAL (d)           |  1/8 (13%)    1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   664          417          234          450         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.424      P=0.147      P=0.416      P=0.257      |
|INCIDENTAL TUMOR       |  P=0.418N     P=0.165      P=0.599N     P=0.567      |
|LOGISTIC REGRESSION    |  P=0.482N     P=0.194      P=0.569      P=0.487      |
|COCHRAN-ARMITAGE       |  P=0.459N                                            |
|FISHER EXACT           |               P=0.276      P=0.594N     P=0.500      |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  11
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Keratoacanthoma                                                          |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/48 (4%)    3/48 (6%)    8/144 (6%)   2/48 (4%)    |
|ADJUSTED (b)           |  21.3%        33.7%         9.0%        20.0%        |
|TERMINAL (d)           |  1/8 (13%)    1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   717          704          416          678         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.497      P=0.369      P=0.403      P=0.462      |
|INCIDENTAL TUMOR       |  P=0.512N     P=0.374      P=0.520      P=0.618      |
|LOGISTIC REGRESSION    |  P=0.533N     P=0.362      P=0.527      P=0.535      |
|COCHRAN-ARMITAGE       |  P=0.516N                                            |
|FISHER EXACT           |               P=0.500      P=0.524      P=0.692N     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Sarcoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  3/48 (6%)    4/48 (8%)   12/144 (8%)   5/48 (10%)   |
|ADJUSTED (b)           |  14.4%        37.5%        28.5%        36.5%        |
|TERMINAL (d)           |  0/8 (0%)     1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   664          683          234          528         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.170      P=0.341      P=0.308      P=0.195      |
|INCIDENTAL TUMOR       |  P=0.336      P=0.348      P=0.471      P=0.432      |
|LOGISTIC REGRESSION    |  P=0.289      P=0.390      P=0.421      P=0.341      |
|COCHRAN-ARMITAGE       |  P=0.311                                             |
|FISHER EXACT           |               P=0.500      P=0.456      P=0.357      |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  12
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Squamous Cell Papilloma                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    1/48 (2%)    3/144 (2%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%         2.6%         4.6%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          544          470          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.612N     P=0.485      P=0.326        (e)        |
|INCIDENTAL TUMOR       |  P=0.525N     P=0.638      P=0.397        (e)        |
|LOGISTIC REGRESSION    |  P=0.558N     P=0.522      P=0.386        (e)        |
|COCHRAN-ARMITAGE       |  P=0.572N                                            |
|FISHER EXACT           |               P=0.500      P=0.420        (e)        |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacan|homa
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  3/48 (6%)    4/48 (8%)   11/144 (8%)   2/48 (4%)    |
|ADJUSTED (b)           |  25.4%        35.4%        13.1%        20.0%        |
|TERMINAL (d)           |  1/8 (13%)    1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   681          544          416          678         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.510N     P=0.361      P=0.383      P=0.623      |
|INCIDENTAL TUMOR       |  P=0.333N     P=0.423      P=0.530      P=0.585N     |
|LOGISTIC REGRESSION    |  P=0.364N     P=0.396      P=0.526      P=0.677N     |
|COCHRAN-ARMITAGE       |  P=0.356N                                            |
|FISHER EXACT           |               P=0.500      P=0.519      P=0.500N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  13
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Skin                                                                          |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                   |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/48 (4%)    4/48 (8%)   11/144 (8%)   2/48 (4%)    |
|ADJUSTED (b)           |  21.3%        35.4%        13.1%        20.0%        |
|TERMINAL (d)           |  1/8 (13%)    1/6 (17%)    0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   717          544          416          678         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.516      P=0.230      P=0.230      P=0.462      |
|INCIDENTAL TUMOR       |  P=0.451N     P=0.281      P=0.337      P=0.618      |
|LOGISTIC REGRESSION    |  P=0.481N     P=0.247      P=0.337      P=0.535      |
|COCHRAN-ARMITAGE       |  P=0.476N                                            |
|FISHER EXACT           |               P=0.339      P=0.324      P=0.692N     |
|==============================================================================|
|                                                                              |
|Testes                                                                        |
|     Adenoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |                                                      |
|-----------            |                                                      |
|OVERALL (a)            | 15/20 (75%)   9/9 (100%)  62/68 (91%)  12/13 (92%)   |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%        |
|TERMINAL (d)           |  5/5 (100%)   3/3 (100%)  12/12 (100%)  1/1 (100%)   |
|FIRST INCIDENCE (DAYS) |   638          589          529          579         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.031 *    P=0.426N     P=0.025 *    P=0.166      |
|INCIDENTAL TUMOR       |  P=0.315      P=0.304      P=0.131      P=0.478      |
|LOGISTIC REGRESSION    |  P=0.172      P=0.130      P=0.043 *    P=0.270      |
|COCHRAN-ARMITAGE       |  P=0.152                                             |
|FISHER EXACT           |               P=0.131      P=0.068      P=0.217      |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  14
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|Tissue NOS                                                                    |
|     Sarcoma                                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  1/48 (2%)    0/48 (0%)    4/144 (3%)   0/48 (0%)    |
|ADJUSTED (b)           |   4.2%         0.0%        10.1%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     1/14 (7%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   663          ---          440          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.608N     P=0.569N     P=0.513      P=0.557N     |
|INCIDENTAL TUMOR       |  P=0.560N     P=0.554N     P=0.587      P=0.512N     |
|LOGISTIC REGRESSION    |  P=0.545N     P=0.520N     P=0.607      P=0.529N     |
|COCHRAN-ARMITAGE       |  P=0.546N                                            |
|FISHER EXACT           |               P=0.500N     P=0.633      P=0.500N     |
|==============================================================================|
|                                                                              |
|Zymbal's Gland                                                                |
|     Carcinoma                                                                |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    0/48 (0%)    4/144 (3%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         7.0%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          ---          481          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.440        (e)        P=0.240        (e)        |
|INCIDENTAL TUMOR       |  P=0.520        (e)        P=0.298        (e)        |
|LOGISTIC REGRESSION    |  P=0.494        (e)        P=0.284        (e)        |
|COCHRAN-ARMITAGE       |  P=0.490                                             |
|FISHER EXACT           |                 (e)        P=0.313        (e)        |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  15
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated       |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 28/48 (58%)  25/48 (52%) 100/144 (69%) 37/48 (77%)   |
|ADJUSTED (b)           |  89.4%        82.5%        97.2%       100.0%        |
|TERMINAL (d)           |  6/8 (75%)    3/6 (50%)   12/14 (86%)   4/4 (100%)   |
|FIRST INCIDENCE (DAYS) |   327          460          389          486         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.002 **   P=0.449      P=0.032 *    P=0.008 **   |
|INCIDENTAL TUMOR       |  P=0.002 **   P=0.386N     P=0.062      P=0.013 *    |
|LOGISTIC REGRESSION    |  P=0.002 **   P=0.337N     P=0.061      P=0.033 *    |
|COCHRAN-ARMITAGE       |  P=0.004 **                                          |
|FISHER EXACT           |               P=0.341N     P=0.109      P=0.040 *    |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Mesothelioma: Benign, Malignant, NOS                                     |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  2/48 (4%)    0/48 (0%)    2/144 (1%)   0/48 (0%)    |
|ADJUSTED (b)           |   6.8%         0.0%         7.0%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   466          ---          669          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.274N     P=0.282N     P=0.359N     P=0.272N     |
|INCIDENTAL TUMOR       |  P=0.206N     P=0.190N     P=0.267N     P=0.171N     |
|LOGISTIC REGRESSION    |  P=0.232N     P=0.212N     P=0.289N     P=0.217N     |
|COCHRAN-ARMITAGE       |  P=0.227N                                            |
|FISHER EXACT           |               P=0.247N     P=0.261N     P=0.247N     |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  16
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Osteosarcoma                                                             |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    0/48 (0%)    2/144 (1%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         5.1%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          ---          641          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.543        (e)        P=0.447        (e)        |
|INCIDENTAL TUMOR       |  P=0.608        (e)        P=0.506        (e)        |
|LOGISTIC REGRESSION    |  P=0.575        (e)        P=0.469        (e)        |
|COCHRAN-ARMITAGE       |  P=0.601                                             |
|FISHER EXACT           |                 (e)        P=0.562        (e)        |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Osteosarcoma or Osteoma                                                  |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            |  0/48 (0%)    0/48 (0%)    2/144 (1%)   0/48 (0%)    |
|ADJUSTED (b)           |   0.0%         0.0%         5.1%         0.0%        |
|TERMINAL (d)           |  0/8 (0%)     0/6 (0%)     0/14 (0%)    0/4 (0%)     |
|FIRST INCIDENCE (DAYS) |   ---          ---          641          ---         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.543        (e)        P=0.447        (e)        |
|INCIDENTAL TUMOR       |  P=0.608        (e)        P=0.506        (e)        |
|LOGISTIC REGRESSION    |  P=0.575        (e)        P=0.469        (e)        |
|COCHRAN-ARMITAGE       |  P=0.601                                             |
|FISHER EXACT           |                 (e)        P=0.562        (e)        |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  17
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Benign Tumors                                                            |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 41/48 (85%)  40/48 (83%) 113/144 (78%) 42/48 (88%)   |
|ADJUSTED (b)           |  97.5%       100.0%        99.0%       100.0%        |
|TERMINAL (d)           |  7/8 (88%)    6/6 (100%)  13/14 (93%)   4/4 (100%)   |
|FIRST INCIDENCE (DAYS) |   484          417          389          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.076      P=0.237      P=0.237      P=0.048 *    |
|INCIDENTAL TUMOR       |  P=0.406      P=0.559N     P=0.328N     P=0.482      |
|LOGISTIC REGRESSION    |  P=0.375      P=0.593      P=0.432N     P=0.369      |
|COCHRAN-ARMITAGE       |  P=0.503                                             |
|FISHER EXACT           |               P=0.500N     P=0.203N     P=0.500      |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant Tumors                                                         |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 36/48 (75%)  30/48 (63%) 118/144 (82%) 40/48 (83%)   |
|ADJUSTED (b)           |  93.0%        88.4%        98.1%       100.0%        |
|TERMINAL (d)           |  6/8 (75%)    3/6 (50%)   12/14 (86%)   4/4 (100%)   |
|FIRST INCIDENCE (DAYS) |   327          460          234          486         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.010 *    P=0.530      P=0.057      P=0.030 *    |
|INCIDENTAL TUMOR       |  P=0.016 *    P=0.174N     P=0.168      P=0.150      |
|LOGISTIC REGRESSION    |  P=0.013 *    P=0.142N     P=0.143      P=0.190      |
|COCHRAN-ARMITAGE       |  P=0.021 *                                           |
|FISHER EXACT           |               P=0.135N     P=0.200      P=0.226      |
|==============================================================================|
         DATE: 05/08/95                     EXPERIMENT: 88034 TEST: 07                                                 PAGE  18
   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- 6  OZONE/NNK
                       TERMINAL SACRIFICE AT 106 WEEKS
|==============================================================================|
|DOSE                   |   TRIOCT./     .1MG/KG      1M/K NNK     1 MG/KG     |
|                       |   AIR          NNK/AIR      /OZONE       NNK/AIR     |
|==============================================================================|
|                                                                              |
|All Organs                                                                    |
|     Malignant and Benign Tumors                                              |
|                                                                              |
|------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #          |
|-----------            |                                                      |
|OVERALL (a)            | 48/48 (100%) 48/48 (100%)139/144 (97%) 48/48 (100%)  |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%        |
|TERMINAL (d)           |  8/8 (100%)   6/6 (100%)  14/14 (100%)  4/4 (100%)   |
|FIRST INCIDENCE (DAYS) |   327          417          234          429         |
|-----------------------|                                                      |
|STATISTICAL TESTS (f)  |                                                      |
|-----------------------|                                                      |
|LIFE TABLE             |  P=0.095      P=0.185      P=0.155      P=0.061      |
|INCIDENTAL TUMOR       |  P=0.451N       (e)        P=0.296N       (e)        |
|LOGISTIC REGRESSION    |  P=0.529N       (e)        P=0.436N       (e)        |
|COCHRAN-ARMITAGE       |  P=0.454N                                            |
|FISHER EXACT           |               P=1.000N     P=0.233N     P=1.000N     |
|==============================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).