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TDMS Study 88034-07 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 05/08/95   
EXP: 88034                        OZONE/NNK                    TIME: 23:09:18   
TEST: 07              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 88034C   
CONT: N01-ES-95262                                             CAS: 10028-15-6  
PATHOLOGIST: P. MELLICK                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 05/08/95  
EXP: 88034                        OZONE/NNK                    TIME: 23:09:18  
TEST: 07              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 88034C  
CONT: N01-ES-95262                                             CAS: 10028-15-6 
PATHOLOGIST: P. MELLICK                                                        

                                     OZONE/NNK


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = TRIOCT./AIR                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 40     CENSORED DEATHS 0    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      327   466   484   515   540   543   556   556   562   564                 |
 |      569   576   585   589   604   611   611   613   620   620                 |
 |      633   638   641   655   663   664   669   672   673   681                 |
 |      692   697   698   700   700   704   706   709   717   724                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = .1MG/KG NNK/AIR                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      417   444   460   466   478   501   501   518   529   544                 |
 |      550   551   555   557   579   582   589   589   612   613                 |
 |      617   620   625   633   635   635   639   641   641   655                 |
 |      662   663   671   673   683   686   697   704   704   710                 |
 |      715   716                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = TRIOCT./OZONE                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 45     CENSORED DEATHS 0    TERMINAL 3         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      192   253   333   389   440   458   487   502   515   523                 |
 |      529   537   550   556   560   580   589   590   592   603                 |
 |      605   611   614   617   624   631   634   634   635   635                 |
 |      636   645   659   661   669   673   678   694   704   705                 |
 |      709   712   718   722   725                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     OZONE/NNK


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = .1M/KNNK/OZONE                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      234   416   444   444   460   481   496   549   550   552                 |
 |      565   567   567   569   575   583   604   604   605   620                 |
 |      632   635   638   641   662   663   669   669   671   673                 |
 |      680   683   683   683   697   698   703   710   713   714                 |
 |      725   733                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1M/K NNK/OZONE                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 43     CENSORED DEATHS 0    TERMINAL 5         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      253   403   416   456   470   503   557   557   558   562                 |
 |      580   581   582   585   597   602   603   603   610   613                 |
 |      617   635   635   640   640   641   655   661   669   669                 |
 |      671   678   683   683   683   687   687   697   700   704                 |
 |      705   712   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1 MG/KG NNK/AIR                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 48     UNCENSORED DEATHS 44     CENSORED DEATHS 0    TERMINAL 4         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      429   450   486   488   489   528   529   533   540   544                 |
 |      550   551   562   579   583   583   590   590   602   603                 |
 |      603   603   604   605   605   617   639   641   645   661                 |
 |      663   669   677   678   683   683   683   683   687   695                 |
 |      695   704   712   715                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     OZONE/NNK


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |TRIOCT./AIR|   100.0 100.0 100.0  97.9  97.9  93.8  87.5  68.8  45.8  16.7      |
 |           |                                                                    |
 |           |                                                                    |
 |.1MG/KG    |   100.0 100.0 100.0 100.0  97.9  89.6  79.2  62.5  33.3  12.5      |
 |NNK/AIR    |                                                                    |
 |           |                                                                    |
 |TRIOCT./OZO|E  100.0 100.0  95.8  93.8  91.7  87.5  75.0  56.3  29.2   6.3      |
 |           |                                                                    |
 |           |                                                                    |
 |.1M/KNNK/OZ|NE 100.0 100.0  97.9  97.9  95.8  87.5  85.4  60.4  45.8  12.5      |
 |           |                                                                    |
 |           |                                                                    |
 |1M/K       |   100.0 100.0  97.9  97.9  93.8  89.6  87.5  62.5  41.7  10.4      |
 |NNK/OZONE  |                                                                    |
 |           |                                                                    |
 |1          |   100.0 100.0 100.0 100.0 100.0  95.8  79.2  47.9  35.4   8.3      |
 |MG/KG NNK/A|R                                                                   |
 |           |                                                                    |
 ==================================================================================

                                     OZONE/NNK


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                TRIOCT./AIR     .1MG/KG         TRIOCT./OZONE   .1M/KNNK/OZONE  1M/K            1            |
 |                                                NNK/AIR                                         NNK/OZONE       MG/KG NNK/AIR|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       16.7%           12.5%            6.3%           12.5%           10.4%            8.3%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.172         P=0.370         P=0.094         P=0.666         P=0.394         P=0.122      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       618.7           601.4           585.1           606.2           608.6           605.9        |
 |NATURAL DEATHS (C)      |       (13.0)          (12.5)          (17.7)          (15.9)          (14.6)          (11.2)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       638.2           618.3           594.5           622.4           621.8           616.7        |
 |(STANDARD ERROR)        |       (12.5)          (12.7)          (17.4)          (15.2)          (14.3)          (11.5)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             OZONE/NNK
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        TRIOCT./AIR      = 1
                                                        .1MG/KG NNK/AIR  = 2
                                                        TRIOCT./OZONE    = 3
                                                        .1M/KNNK/OZONE   = 4
                                                        1M/K NNK/OZONE   = 5
                                                        1 MG/KG NNK/AIR  = 6

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  100.00 +1                              3     4   3          1           5 2 6 2 6 1
         |                                         3           3        3 5 4   2 621  1   1
         |                                                              3      34  32526 2 1  6 1
         |                                                                         3  4342 2  66141
P  83.33 +                                                                               3 2 3262 11
E        |                                                                                   33322 111
R        |                                                                                     3 224411 1
C        |                                                                                        2 422 1511
E  66.67 +                                                                                           32 254
N        |                                                                                              26311
T        |                                                                                                321 11
         |                                                                                                 32221 1
S  50.00 +                                                                                                6 3334 1 1
U        |                                                                                                  6 22 5 11
R        |                                                                                                     262 5111
V        |                                                                                                    3 32 254111
I  33.33 +                                                                                                      3  2225
V        |                                                                                                         3322511
A        |                                                                                                           325211
L        |                                                                                                            6632111
   16.67 +                                                                                                              63221 41
         |                                                                                                               6323 42
         |                                                                                                                 63  3
         |
    0.00 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 164 obs hidden.