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TDMS Study 88035-06 Pathology Tables

NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96
Route: DOSED FEED                                                                                                 Time: 16:43:08




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  0000125-33-7

       Lock Date:  11/17/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     001   001                      0 PPM
                               Merge     002   002                      0 PPM
                               Merge     003   003                      300 PPM
                               Merge     004   004                      300 PPM
                               Merge     005   005                      600 PPM
                               Merge     006   006                      600 PPM
                               Merge     007   007                      1300 PPM
                               Merge     008   008                      1300 PPM





























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            7            2            3                                     
    Moribund Sacrifice                                 7            1            3            8                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           42           44           39                                     
  Missing                                                                        1                                                  

  Animals Examined Microscopically                    50           50           49           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (49)         (50)                                   
   Intestine Small, Ileum                             (45)         (49)         (49)         (49)                                   
   Liver                                              (50)         (50)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatoblastoma                                   1 (2%)       3 (6%)       3 (6%)       4 (8%)                                
      Hepatoblastoma, Multiple                                      1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                         3 (6%)       7 (14%)     14 (29%)     13 (26%)                               
      Hepatocellular Carcinoma, Multiple                            4 (8%)       5 (10%)     25 (50%)                               
      Hepatocellular Adenoma                           8 (16%)      5 (10%)      6 (12%)      5 (10%)                               
      Hepatocellular Adenoma, Multiple                 7 (14%)     37 (74%)     39 (80%)     42 (84%)                               
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
   Mesentery                                          (5)          (5)          (6)          (2)                                    
      Histiocytic Sarcoma                                                        1 (17%)                                            
   Pancreas                                           (50)         (48)         (49)         (50)                                   
   Salivary Glands                                    (50)         (48)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Capsule, Adenoma                                              1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (49)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (49)         (48)         (49)         (48)                                   

                                                             Page   2                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Pars Distalis, Adenoma                           3 (6%)       5 (10%)      6 (12%)      6 (13%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (50)         (48)         (48)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (48)         (50)                                   
      Cystadenoma                                      3 (6%)                    2 (4%)       1 (2%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Uterus                                             (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Polyp Stromal                                    1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Sarcoma Stromal                                  1 (2%)                                                                       
      Cervix, Histiocytic Sarcoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (6)          (8)          (7)          (4)                                    
      Deep Cervical, Alveolar/Bronchiolar                                                                                           
          Carcinoma, Metastatic, Lung                               1 (13%)                                                         
      Lumbar, Histiocytic Sarcoma                                   1 (13%)                                                         
      Renal, Histiocytic Sarcoma                                    1 (13%)                                                         
   Lymph Node, Mandibular                             (48)         (44)         (45)         (46)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (48)         (47)         (47)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Spleen                                             (50)         (48)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Thymus                                             (45)         (47)         (44)         (44)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (47)                                   
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (49)         (50)                                   
      Subcutaneous Tissue, Fibrosarcoma                3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Maxilla, Carcinoma, Metastatic, Harderian                                                                                     
          Gland                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       3 (6%)                    1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                    1 (2%)       1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (5)          (5)          (3)          (1)                                    
      Adenoma                                          3 (60%)      5 (100%)     3 (100%)     1 (100%)                              
      Carcinoma                                        2 (40%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
   Urinary Bladder                                    (50)         (49)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             

                                                             Page   4                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)                                             
      Lymphoma Malignant                               8 (16%)      6 (12%)      8 (16%)      5 (10%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            34          47          47          50                                       
     Total Primary Neoplasms                           57          89          97         111                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          45          46          47                                       
     Total Benign Neoplasms                            32          59          62          61                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          23          26          40                                       
     Total Malignant Neoplasms                         25          30          35          50                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1           2                                       
     Total Metastatic Neoplasm                          3           2           3           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 6            7            6           17                                     
    Natural Death                                      9            9           13           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           33           31           19                                     
    Natural Death                                                   1                                                               

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (48)         (49)         (50)         (47)                                   
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (49)         (50)         (47)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Small, Ileum                             (42)         (47)         (49)         (48)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       3 (6%)                                                          
      Hepatoblastoma                                               15 (30%)     21 (42%)      6 (12%)                               
      Hepatoblastoma, Multiple                                      2 (4%)       5 (10%)      1 (2%)                                
      Hepatocellular Carcinoma                        10 (20%)     21 (42%)     13 (26%)     19 (38%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)      10 (20%)     22 (44%)     19 (38%)                               
      Hepatocellular Adenoma                          16 (32%)     12 (24%)      5 (10%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                 6 (12%)     29 (58%)     34 (68%)     22 (44%)                               
      Histiocytic Sarcoma                                                                     4 (8%)                                
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Mesentery                                          (1)          (2)          (1)          (1)                                    
      Fat, Histiocytic Sarcoma                                                                1 (100%)                              
   Pancreas                                           (46)         (48)         (50)         (47)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
   Stomach, Forestomach                               (50)         (49)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Capsule, Adenoma                                 1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (45)         (48)         (49)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
   Thyroid Gland                                      (49)         (48)         (50)         (50)                                   
      Follicular Cell, Adenoma                                      3 (6%)       3 (6%)       6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
   Prostate                                           (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
   Lymph Node                                         (1)          (4)          (1)          (3)                                    
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (25%)                                                         
   Lymph Node, Mesenteric                             (48)         (48)         (49)         (42)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (48)         (49)         (50)         (49)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
      Hepatoblastoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Histiocytic Sarcoma                                                                     2 (4%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
   Thymus                                             (42)         (40)         (42)         (34)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Hepatoblastoma, Metastatic, Liver                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      7 (14%)      5 (10%)      5 (10%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                 1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       1 (2%)       1 (2%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             2 (4%)      11 (22%)      5 (10%)                               
      Hepatocellular Carcinoma, Metastatic, Liver      5 (10%)      5 (10%)      4 (8%)       5 (10%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Mediastinum, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (3)          (1)          (2)                                    
      Adenoma                                          2 (100%)     2 (67%)      1 (100%)     1 (50%)                               
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)       1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                 5 (10%)                               
      Lymphoma Malignant                               7 (14%)      4 (8%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 88035-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 12/30/96  
Route: DOSED FEED                                                                                                 Time: 16:43:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        300 PPM      600 PPM      1300 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          50          50          47                                       
     Total Primary Neoplasms                           68         112         115         101                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 26          42          39          36                                       
     Total Benign Neoplasms                            34          54          50          46                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          42          42          42                                       
     Total Malignant Neoplasms                         34          58          65          55                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           9          14          11                                       
     Total Metastatic Neoplasm                          6          11          20          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                       1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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