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TDMS Study 88035-05 Pathology Tables

NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96
Route: DOSED FEED                                                                                                 Time: 10:21:25

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  0000125-33-7

       Lock Date:  11/17/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           18           14           19                                     
    Natural Death                                      5            5            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           27           31           27                                     
    Natural Death                                                                             1                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Cecum                             (49)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Intestine Small, Duodenum                          (49)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (49)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Intestine Small, Ileum                             (50)         (50)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Hepatocellular Adenoma                                        1 (2%)                    1 (2%)                                
   Mesentery                                          (9)          (10)         (7)          (7)                                    
      Fibrosarcoma, Metastatic, Spleen                                                        1 (14%)                               
   Oral Mucosa                                                                               (2)                                    
      Gingival, Squamous Cell Carcinoma                                                       1 (50%)                               
      Pharyngeal, Squamous Cell Carcinoma                                                     1 (50%)                               
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (49)         (50)         (50)         (50)                                   
      Carcinoid Tumor Benign                           1 (2%)                                                                       
      Carcinoid Tumor Malignant                        1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)         (50)                                   
   Heart                                              (49)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                             Page   2                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)                    1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus            1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Benign                          2 (4%)                    2 (4%)       3 (6%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Parathyroid Gland                                  (38)         (44)         (42)         (39)                                   
   Pituitary Gland                                    (49)         (50)         (49)         (50)                                   
      Pars Distalis, Adenoma                          16 (33%)     20 (40%)     13 (27%)     18 (36%)                               
      Pars Distalis, Adenoma, Multiple                              1 (2%)       1 (2%)       2 (4%)                                
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  5 (10%)      2 (4%)       6 (12%)      4 (8%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (49)         (50)         (50)                                   
      Adenoma                                          4 (8%)       1 (2%)       4 (8%)       1 (2%)                                
      Carcinoma                                        1 (2%)                    1 (2%)       2 (4%)                                
   Ovary                                              (50)         (50)         (50)         (49)                                   
      Granulosa-Theca Tumor Malignant                               1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (49)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    7 (14%)      7 (14%)      6 (12%)      7 (14%)                               
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                               3 (6%)                    3 (6%)                                
   Vagina                                             (1)                       (1)          (2)                                    
      Polyp                                            1 (100%)                               2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (11)         (7)          (8)          (12)                                   
      Thoracic, Carcinoma, Metastatic, Mammary                                                                                      
          Gland                                                                  1 (13%)                                            

                                                             Page   3                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (49)         (50)         (50)         (50)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Fibrosarcoma                                                                            1 (2%)                                
   Thymus                                             (49)         (45)         (47)         (46)                                   
      Thymoma Benign                                                             1 (2%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)                                             
      Fibroadenoma                                    13 (26%)     21 (42%)     14 (28%)     11 (22%)                               
      Fibroadenoma, Multiple                           9 (18%)      4 (8%)       2 (4%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Pinna, Squamous Cell Papilloma                                             1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
   Spinal Cord                                                     (1)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Thymoma Malignant, Metastatic, Thymus            1 (2%)                                                                       
   Trachea                                            (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)                                                 
      Carcinoma                                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
   Urinary Bladder                                    (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            13 (26%)     13 (26%)     13 (26%)     22 (44%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          44          41          46                                       
     Total Primary Neoplasms                           86          81          72          88                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          35          35          33                                       
     Total Benign Neoplasms                            63          60          53          54                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          20          17          28                                       
     Total Malignant Neoplasms                         23          21          19          34                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           2                                       
     Total Metastatic Neoplasm                          2                       2           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                33           33           39           36                                     
    Natural Death                                      4           10            7           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                13            7            4                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (46)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (50)         (50)         (47)                                   
   Intestine Small, Jejunum                           (50)         (50)         (49)         (45)                                   
      Carcinoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)         (49)         (46)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                 1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)                                             
   Mesentery                                          (11)         (6)          (9)          (3)                                    
      Fat, Fibrosarcoma, Metastatic, Spleen            1 (9%)                                                                       
   Oral Mucosa                                        (1)                                                                           
      Pharyngeal, Squamous Cell Carcinoma              1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (49)                                   
   Salivary Glands                                    (50)         (50)         (49)         (49)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
   Tooth                                                           (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                         16 (32%)     19 (38%)     19 (38%)      7 (14%)                               
      Bilateral, Pheochromocytoma Benign               7 (14%)      9 (18%)      5 (10%)      5 (10%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (45)         (41)         (46)         (49)                                   
   Pituitary Gland                                    (49)         (50)         (48)         (49)                                   
      Pars Distalis, Adenoma                          17 (35%)     12 (24%)     11 (23%)      4 (8%)                                
      Pars Intermedia, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  7 (14%)      2 (4%)       7 (14%)      1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)                    1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       6 (12%)      3 (6%)                                
      Follicular Cell, Carcinoma                       1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (1)          (1)          (1)                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (2)          (1)                       (1)                                    
   Epididymis                                         (50)         (50)         (50)         (48)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          2 (4%)       1 (2%)       2 (4%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)         (48)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (48)                                   
   Testes                                             (50)         (50)         (50)         (48)                                   
      Bilateral, Interstitial Cell, Adenoma           33 (66%)     33 (66%)     35 (70%)     34 (71%)                               
      Interstitial Cell, Adenoma                       8 (16%)     11 (22%)      7 (14%)      9 (19%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (24)         (23)         (16)         (10)                                   
   Lymph Node, Mandibular                             (50)         (50)         (48)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (48)                                   

                                                             Page   8                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Fibrosarcoma                                     3 (6%)       1 (2%)                                                          
   Thymus                                             (49)         (47)         (44)         (46)                                   
      Thymoma Malignant                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (50)         (47)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        2 (4%)                                                                       
      Fibroadenoma                                     3 (6%)       3 (6%)       3 (6%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Basosquamous Tumor Benign                                     1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Trichoepithelioma                                                                       1 (2%)                                
      Pinna, Melanoma Malignant                                                  1 (2%)                                             
      Pinna, Squamous Cell Papilloma                                1 (2%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (6%)       3 (6%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Pinna, Melanoma Benign      1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chordoma                                         1 (2%)                                                                       
      Mandible, Osteosarcoma                           1 (2%)                                                                       
      Tibia, Osteosarcoma                                           1 (2%)                                                          
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (49)                                   
      Astrocytoma Malignant                                                                   2 (4%)                                
   Peripheral Nerve                                   (1)          (1)                                                              
      Spinal, Schwannoma Malignant                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)       1 (2%)                                
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Spleen                 1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Squamous Cell Carcinoma                                                    1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                 1 (2%)                                                                       
      Lipoma                                                                                  1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Renal Tubule, Adenoma                            2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (48)                                   
      Papilloma                                                                  1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            35 (70%)     30 (60%)     24 (48%)     12 (24%)                               
      Lymphoma Malignant                                                         1 (2%)                                             
      Mesothelioma Malignant                           2 (4%)       3 (6%)       2 (4%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 88035-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PRIMACLONE                                        Date: 10/01/96  
Route: DOSED FEED                                                                                                 Time: 10:21:25  
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         FISCHER 344 RATS MALE                     0.0%         0.06%        0.13%        0.25%                                     
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50          47                                       
     Total Primary Neoplasms                          160         144         143          87                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          49          44                                       
     Total Benign Neoplasms                           105         103         107          69                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          35          29          15                                       
     Total Malignant Neoplasms                         55          41          36          18                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       1                                                   
     Total Metastatic Neoplasm                          7                       1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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