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TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:32:19

                                                       51 WEEK SSAC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     11/01/95 - 11/01/95

       Treatment Groups:       Include 002    0 PPM
                               Include 010    3750 PPM
                               Include 001    0 PPM
                               Include 009    3750 PPM































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)                                                                      
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 3 (60%)                                                                      
      Hepatodiaphragmatic Nodule                                    1 (20%)                                                         
      Inflammation                                     3 (60%)      3 (60%)                                                         
      Bile Duct, Hyperplasia                                        1 (20%)                                                         
      Centrilobular, Hypertrophy                                    5 (100%)                                                        
   Pancreas                                           (5)          (5)                                                              
      Atrophy                                          2 (40%)      2 (40%)                                                         
   Stomach, Glandular                                 (5)          (5)                                                              
      Erosion                                          1 (20%)                                                                      
      Ulcer                                                         1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (5)          (5)                                                              
      Cardiomyopathy                                   3 (60%)      1 (20%)                                                         
      Inflammation                                                  1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (5)          (5)                                                              
      Hyperplasia                                      1 (20%)                                                                      
   Pituitary Gland                                    (5)          (5)                                                              
      Angiectasis                                      1 (20%)      1 (20%)                                                         
      Cyst                                                          1 (20%)                                                         
      Pars Distalis, Hyperplasia                       1 (20%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (5)          (5)                                                              
      Inflammation                                     5 (100%)     5 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                                   5 (100%)                                                        
   Lymph Node, Mandibular                             (5)          (5)                                                              
      Hyperplasia, Plasma Cell                                      1 (20%)                                                         
   Thymus                                             (5)          (5)                                                              
      Atrophy                                                       1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (5)          (5)                                                              
      Inflammation                                     5 (100%)     4 (80%)                                                         
   Trachea                                            (5)          (5)                                                              
      Inflammation                                     1 (20%)      3 (60%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)                                                              
      Accumulation, Hyaline Droplet                    2 (40%)      5 (100%)                                                        
      Nephropathy                                      3 (60%)      5 (100%)                                                        
      Medulla, Mineralization                          1 (20%)      4 (80%)                                                         
   Urinary Bladder                                    (5)          (5)                                                              
      Inflammation                                     2 (40%)      1 (20%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (5)          (5)                                                              
      Parasite Metazoan                                2 (40%)      4 (80%)                                                         
   Intestine Large, Cecum                             (5)          (5)                                                              
      Ulcer                                                         1 (20%)                                                         
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 2 (40%)                                                                      
      Hepatodiaphragmatic Nodule                                    1 (20%)                                                         
      Inflammation                                     4 (80%)      3 (60%)                                                         
      Necrosis                                         4 (80%)      1 (20%)                                                         
      Vacuolization Cytoplasmic                        4 (80%)      5 (100%)                                                        
      Bile Duct, Hyperplasia                           4 (80%)      4 (80%)                                                         
      Centrilobular, Hypertrophy                                    5 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (5)          (5)                                                              
      Cardiomyopathy                                   5 (100%)     5 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (5)          (5)                                                              
      Pars Distalis, Hyperplasia                       1 (20%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (5)          (5)                                                              
      Inflammation                                     2 (40%)                                                                      
   Preputial Gland                                    (5)          (5)                                                              
      Inflammation                                     5 (100%)     3 (60%)                                                         
   Prostate                                           (5)          (5)                                                              
      Inflammation                                     3 (60%)      4 (80%)                                                         
   Testes                                             (5)          (5)                                                              
      Atrophy                                          1 (20%)                                                                      
      Interstitial Cell, Hyperplasia                   4 (80%)      4 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                                   3 (60%)                                                         
   Thymus                                             (5)          (5)                                                              
      Atrophy                                          2 (40%)      4 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (5)          (5)                                                              
      Inflammation                                     1 (20%)      2 (40%)                                                         
   Nose                                               (5)          (5)                                                              
      Inflammation                                     1 (20%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:32:19  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        3750 PPM                                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)                                                              
      Accumulation, Hyaline Droplet                                 5 (100%)                                                        
      Nephropathy                                      5 (100%)     5 (100%)                                                        
      Medulla, Mineralization                                       5 (100%)                                                        
   Urinary Bladder                                    (5)          (5)                                                              
      Inflammation                                                  1 (20%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------