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TDMS Study 88036-03 Pathology Tables

NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                  ANTHRAQUINONE                                             DATE: 02/26/99    
EXPERIMENT: 88036 TEST: 03                                                                                        TIME: 08:02:42    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88036      
CONT: N01-ES-25337                                                                                                CAS: 84-65-1      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39

LAB: BATTELLE COLUMBUS LABORATORY                     ANTHRAQUINONE                                               DATE: 02/26/99


EXPERIMENT: 88036 TEST: 03                                                                                        TIME:  8:11:33



TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88036

CONT: N01-ES-25337                                                                                                CAS: 84-65-1
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
                                               CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE

==================================================================================================================================
           0 PPM                      469 PPM                            938 PPM                            1875 PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                          DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  1    14.6   112.8      14.4    112.2    0.99       60     14.5    114.2    0.99      124     14.3    112.6    0.98      238
  2    15.5   149.0      15.3    148.0    0.99       48     14.7    148.6    0.95       97     14.8    148.1    0.95      188
  6    17.4   252.2      16.8    246.0    0.97       32     16.5    241.2    0.95       67     16.5    242.0    0.95      128
 10    16.9   300.8      16.5    294.4    0.98       26     16.9    293.1    1.00       57     17.0    286.4    1.01      111
 14    18.6   335.9      18.1    328.5    0.97       26     17.6    323.3    0.95       53     17.6    316.9    0.95      104
 18    17.5   360.9      17.2    354.3    0.98       23     16.6    346.1    0.95       47     16.9    348.6    0.97       91
 22    18.3   378.6      17.5    372.8    0.96       22     17.3    366.6    0.95       46     17.3    370.4    0.95       88
 26    16.1   395.1      16.5    392.9    1.02       20     16.2    389.2    1.01       41     17.2    389.9    1.07       83
 30    17.9   408.5      17.7    407.4    0.99       20     17.6    404.1    0.98       43     17.7    405.3    0.99       82
 34    18.2   416.2      17.5    419.1    0.96       20     16.8    413.8    0.92       40     17.4    414.3    0.96       79
 38    17.1   423.0      16.9    425.4    0.99       19     16.7    418.3    0.98       39     17.2    419.7    1.01       77
 42    17.9   429.8      17.4    432.4    0.97       19     18.3    422.5    1.02       42     17.7    428.9    0.99       77
 46    18.2   436.3      17.9    440.0    0.98       19     18.3    433.1    1.01       42     18.5    439.6    1.02       79
 50    17.5   440.9      17.2    438.6    0.98       18     17.8    433.8    1.02       40     18.2    437.3    1.04       78
 54    18.2   446.6      17.4    443.2    0.96       18     17.6    437.6    0.97       40     17.7    440.4    0.97       76
 58    16.9   457.5      16.6    450.3    0.98       17     16.5    443.9    0.98       37     18.0    446.1    1.07       76
 62    18.0   466.1      17.8    460.7    0.99       18     17.9    453.2    0.99       39     18.9    456.9    1.05       77
 66    17.0   468.3      17.3    461.1    1.02       18     17.5    456.8    1.03       38     18.1    464.2    1.06       73
 70    16.6   467.7      16.6    460.8    1.00       17     15.9    452.5    0.96       35     16.5    459.2    0.99       67
 74    15.6   470.7      17.1    456.2    1.10       18     16.5    454.7    1.06       36     17.0    458.8    1.09       69
 78    15.8   474.9      16.9    457.6    1.07       17     16.4    449.4    1.04       36     16.9    455.8    1.07       69
 82    15.8   475.7      16.3    456.4    1.03       17     16.5    446.8    1.04       36     16.1    451.6    1.02       67
 86    14.9   471.0      14.7    444.2    0.99       16     15.7    438.5    1.05       35     14.8    441.1    0.99       63
 90    16.8   462.4      16.8    442.3    1.00       18     17.5    431.5    1.04       40     17.6    439.8    1.05       75
 94    14.0   448.1      15.7    425.3    1.12       17     16.7    426.8    1.19       38     16.3    422.6    1.16       72
 98    16.1   449.8      17.0    429.0    1.06       19     16.1    424.8    1.00       37     17.0    418.2    1.06       76
102    14.8   430.3      15.2    405.3    1.03       18     15.4    399.6    1.04       38     17.7    414.2    1.20       80

1 TO 13 WEEKS 
----------------
MEAN   16.1   203.7      15.8    200.2    0.98       42     15.6    199.3    0.97       86     15.6    197.3    0.97      166
SD(D)   1.3               1.1             0.01       15      1.2             0.03       31      1.3             0.03       58
CV(E)   8.1               7.3             1.0      36.9      8.0             2.9      35.4      8.3             2.7      34.9

14 TO 52 WEEKS
----------------
MEAN   17.7   402.5      17.4    401.1    0.98       21     17.3    395.1    0.98       43     17.6    397.1    0.99       84
SD(D)   0.7               0.5             0.02        2      0.7             0.04        4      0.5             0.04        8
CV(E)   4.0               2.7             1.9      11.5      4.1             3.6      10.1      2.8             4.1      10.1

> 52 WEEKS    
----------------
MEAN   16.2   460.7      16.6    445.6    1.03       17     16.6    439.7    1.03       37     17.1    443.8    1.06       72
SD(D)   1.2               0.9             0.05        1      0.8             0.06        2      1.1             0.06        5
CV(E)   7.6               5.4             4.7       4.5      4.7             5.8       4.5      6.2             6.0       6.8
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
   CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE

==========================================
                    3750 PPM
       ---------------------------------
                         DOSE/
       GRAMS    BODY    CONTROL
       FEED/   WEIGHT  FEED (B)    DOSE/
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==========================================
  1    13.3    112.5     0.91     442
  2    14.3    144.9     0.92     370
  6    16.0    236.6     0.92     254
 10    16.7    284.7     0.99     220
 14    17.7    321.6     0.95     206
 18    17.0    348.0     0.97     183
 22    17.6    365.9     0.96     180
 26    16.9    383.2     1.05     166
 30    18.4    399.6     1.03     173
 34    17.5    408.6     0.96     161
 38    17.6    416.6     1.03     159
 42    18.1    426.2     1.01     159
 46    18.7    430.7     1.03     163
 50    17.1    428.7     0.98     149
 54    18.4    424.6     1.01     162
 58    16.2    430.4     0.96     141
 62    17.7    443.6     0.98     149
 66    18.0    446.9     1.06     151
 70    16.4    443.0     0.99     139
 74    17.0    448.5     1.09     142
 78    16.3    441.7     1.03     139
 82    15.9    437.8     1.01     136
 86    16.1    433.6     1.08     139
 90    16.6    429.8     0.99     145
 94    16.8    419.9     1.20     150
 98    16.9    413.8     1.05     153
102    16.4    401.9     1.11     153

1 TO 13 WEEKS 
----------------
MEAN   15.1    194.7     0.94     322
SD(D)   1.6              0.04     103
CV(E)  10.4              3.8     32.0

14 TO 52 WEEKS
----------------
MEAN   17.7    392.9     1.00     170
SD(D)   0.6              0.04      16
CV(E)   3.4              3.6      9.7

> 52 WEEKS    
----------------
MEAN   16.8    432.0     1.04     146
SD(D)   0.8              0.07       8
CV(E)   4.5              6.3      5.2
==========================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
                                               CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE

==================================================================================================================================
           0 PPM                      469 PPM                            938 PPM                            1875 PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                           DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  1    11.3   100.7      11.7    101.3     1.04      54     10.9    102.0     0.96     105     10.4    100.3     0.92     194
  2    11.3   118.3      11.5    118.7     1.02      45     10.7    117.4     0.95      90     10.5    116.0     0.93     169
  6    10.8   164.6      10.9    160.6     1.01      32     11.1    156.0     1.03      70     10.9    156.1     1.01     132
 10     8.9   181.8       9.4    176.3     1.06      25      9.9    171.3     1.11      57     10.3    168.7     1.16     114
 14    11.1   195.4      11.0    186.8     0.99      28     10.2    182.3     0.92      55     10.6    184.7     0.95     107
 18    10.3   207.6      10.7    198.7     1.04      25      9.1    187.3     0.88      48      9.2    190.5     0.89      90
 22     9.8   215.1       9.1    201.8     0.93      21      9.8    195.2     1.00      49      8.8    191.8     0.90      86
 26     9.7   226.4       9.5    209.7     0.98      21      9.6    202.6     0.99      46      9.2    198.9     0.95      87
 30    10.6   231.2       9.4    213.2     0.89      21      9.8    206.4     0.92      47      9.7    203.2     0.92      90
 34     9.9   238.0      10.1    218.2     1.02      22      9.4    209.1     0.95      44      9.4    204.8     0.95      86
 38    10.5   241.6       8.9    213.0     0.85      19     10.2    208.8     0.97      48      9.7    205.4     0.92      88
 42    10.3   249.7      10.3    225.8     1.00      21      9.7    213.5     0.94      45     10.0    209.6     0.97      90
 46    10.3   260.7      10.7    232.0     1.04      22      9.9    219.0     0.96      44     10.2    213.0     0.99      89
 50     9.8   261.1      10.3    233.1     1.05      21     10.0    219.4     1.02      45     10.1    214.0     1.03      89
 54    11.9   268.5      10.7    238.9     0.90      21     11.2    221.7     0.94      50     10.7    218.8     0.90      91
 58    11.3   270.7      10.5    246.8     0.93      20     10.7    230.2     0.95      46     10.7    225.0     0.95      89
 62    12.2   293.1      12.1    261.4     0.99      22     11.4    242.9     0.93      46     10.9    234.5     0.89      87
 66    11.8   302.4      11.3    267.2     0.96      20     10.9    252.0     0.92      43     11.5    245.4     0.97      88
 70    11.2   311.4      11.5    273.2     1.03      20     11.1    257.7     0.99      42     10.6    250.5     0.95      80
 74    11.4   318.4      11.3    281.2     0.99      19     12.4    269.6     1.09      45     12.0    261.8     1.05      86
 78    10.8   319.7      11.3    284.9     1.05      19     10.8    271.7     1.00      39     11.1    267.2     1.03      78
 82    10.9   321.9      11.9    289.6     1.09      19     10.7    275.0     0.98      38     10.5    272.5     0.96      72
 86    11.6   330.2      11.2    290.2     0.97      18     11.0    279.5     0.95      39     11.2    276.5     0.97      76
 90    11.8   335.4      11.9    298.5     1.01      19     11.4    282.5     0.97      40     11.4    280.8     0.97      76
 94    11.7   337.9      12.6    299.0     1.08      20     11.4    280.5     0.97      40     10.1    274.1     0.86      69
 98    12.0   345.4      12.0    306.0     1.00      18     12.2    295.5     1.02      41     12.7    287.6     1.06      83
102    12.0   342.5      11.6    305.0     0.97      18     10.9    290.2     0.91      37     11.1    284.4     0.93      73

1 TO 13 WEEKS 
----------------
MEAN   10.6   141.3      10.9    139.2     1.03      39     10.7    136.7     1.01      80     10.5    135.3     1.00     152
SD(D)   1.1               1.0              0.02      13      0.5              0.07      21      0.3              0.11      36
CV(E)  10.8               9.3              2.0     33.5      4.9              7.4     26.2      2.9             10.9     23.7

14 TO 52 WEEKS
----------------
MEAN   10.2   232.7      10.0    213.2     0.98      22      9.8    204.4     0.96      47      9.7    201.6     0.95      90
SD(D)   0.4               0.7              0.07       2      0.3              0.04       3      0.5              0.04       6
CV(E)   4.2               7.3              7.1     11.0      3.5              4.3      6.8      5.6              4.5      6.8

> 52 WEEKS    
----------------
MEAN   11.6   315.2      11.5    280.1     1.00      19     11.2    265.3     0.97      42     11.1    259.9     0.96      81
SD(D)   0.4               0.6              0.06       1      0.5              0.05       4      0.7              0.06       7
CV(E)   3.9               5.1              5.5      5.7      4.7              4.8      9.0      6.1              6.2      8.9
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
   CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE

==========================================
                    3750 PPM
       ---------------------------------
                         DOSE/
       GRAMS    BODY    CONTROL
       FEED/   WEIGHT  FEED (B)    DOSE/
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==========================================
  1    10.2    101.6     0.90     375
  2    11.0    117.3     0.97     352
  6    10.9    156.7     1.01     260
 10     9.1    165.8     1.02     207
 14    10.6    176.7     0.95     226
 18    10.2    184.2     0.99     208
 22     9.8    191.1     1.00     193
 26     9.4    194.6     0.97     181
 30     9.9    197.2     0.93     189
 34    10.1    201.5     1.02     189
 38     9.5    198.7     0.90     179
 42    10.0    204.0     0.97     184
 46    10.4    208.6     1.01     188
 50    10.6    211.0     1.08     188
 54    10.6    214.0     0.89     185
 58    11.0    221.8     0.97     186
 62    11.5    233.5     0.94     185
 66    11.0    238.3     0.93     173
 70    11.0    248.7     0.98     166
 74    11.3    257.9     0.99     164
 78    11.6    261.9     1.07     166
 82    11.1    264.2     1.02     158
 86    11.5    268.1     0.99     161
 90    11.6    275.2     0.98     157
 94    11.5    271.1     0.98     159
 98    12.0    276.8     1.00     163
102    10.9    271.9     0.91     150

1 TO 13 WEEKS 
----------------
MEAN   10.3    135.4     0.98     298
SD(D)   0.9              0.05      79
CV(E)   8.4              5.5     26.4

14 TO 52 WEEKS
----------------
MEAN   10.1    196.8     0.98     192
SD(D)   0.4              0.05      14
CV(E)   4.2              5.0      7.4

> 52 WEEKS    
----------------
MEAN   11.3    254.1     0.97     167
SD(D)   0.4              0.05      12
CV(E)   3.4              4.9      7.0
==========================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                              DIAGNOSTIC TRAILER REPORT
                                              FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
                                              CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
           0 PPM                   469 PPM                  938 PPM                  1875 PPM                 3750 PPM
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
===================================================================================================================================
  B              112.8  60                112.2  50                114.2  50                112.6  50                112.5  60
  1  14.6  4130  112.8  60    14.4  3425  112.2  50    14.5  3412  114.2  50    14.3  3405  112.6  50    13.3  4120  112.5  60
  2  15.5  5760  149.0  60    15.3  4798  148.0  50    14.7  4806  148.6  50    14.8  4496  148.1  50    14.3  5775  144.9  60
  5  17.0  4500               16.6  3727               16.2  3712               16.2  3669               16.3  4402           
  6  17.4  5755  252.2  60    16.8  4834  246.0  50    16.5  4325  241.2  50    16.5  4883  242.0  50    16.0  5876  236.6  60
  9  17.6  4245               17.1  3539               17.2  3550               17.5  3557               17.2  4284           
 10  16.9  5840  300.8  60    16.5  4868  294.4  50    16.9  4897  293.1  50    17.0  4966  286.4  50    16.7  5831  284.7  59
 13  17.1  4425               16.9  3711               16.3  3734               17.3  3761               17.0  4410           
 14  18.6  5651  335.9  60    18.1  4724  328.5  50    17.6  4737  323.3  50    17.6  4754  316.9  50    17.7  5657  321.6  59
 17  16.6  4020               15.8  3637               16.7  3612               16.4  3595               16.3  3913           
 18  17.5  5177  360.9  55    17.2  4721  354.3  50    16.6  4833  346.1  50    16.9  4917  348.6  50    17.0  5138  348.0  54
 21  17.1  3974               17.3  3633               17.5  3651               16.8  3662               17.4  3912           
 22  18.3  5211  378.6  55    17.5  4826  372.8  50    17.3  4943  366.6  50    17.3  4744  370.4  50    17.6  5185  365.9  54
 25  16.8  3908               16.5  3566               16.2  3578               16.2  3567               16.6  3859           
 26  16.1  5316  395.1  55    16.5  4771  392.9  50    16.2  4834  389.2  50    17.2  4885  389.9  50    16.9  5195  383.2  54
 29  16.4  4075               16.8  3688               17.4  3711               16.9  3709               17.1  3984           
 30  17.9  5323  408.5  55    17.7  4811  407.4  50    17.6  4805  404.1  50    17.7  4830  405.3  50    18.4  5158  399.6  54
 33  19.5  3753               18.4  3450               18.3  3450               17.9  3450               18.3  3684           
 34  18.2  5388  416.2  55    17.5  4884  419.1  50    16.8  4864  413.8  50    17.4  4865  414.3  50    17.5  5284  408.6  54
 37  16.7  4025               16.3  3718               16.4  3666               16.0  3590               16.8  4016           
 38  17.1  5376  423.0  55    16.9  4784  425.4  50    16.7  4874  418.3  50    17.2  4489  419.7  49    17.6  5128  416.6  54
 41  17.1  4060               16.7  3702               17.0  3729               16.9  3670               16.8  3982           
 42  17.9  5277  429.8  55    17.4  4816  432.4  50    18.3  4823  422.5  50    17.7  4738  428.9  49    18.1  5170  426.2  54
 45  16.5  4170               16.7  3768               17.3  3769               17.0  3707               17.0  4112           
 46  18.2  5097  436.3  55    17.9  4602  440.0  50    18.3  4445  433.1  49    18.5  4473  439.6  49    18.7  4919  430.7  54
 49  17.0  3929               16.7  3585               18.0  3513               17.9  3496               17.6  3862           
 50  17.5  5325  440.9  55    17.2  4851  438.6  50    17.8  4738  433.8  49    18.2  4723  437.3  49    17.1  5234  428.7  54
 53  16.1  3465               17.3  3491               17.5  3459               18.8  3419               17.0  3445           
 54  18.2  4977  446.6  50    17.4  4932  443.2  50    17.6  4826  437.6  49    17.7  4847  440.4  49    18.4  4794  424.6  49
 57  17.3  3535               16.9  3582               17.1  3538               17.9  3532               17.7  3532           
 58  16.9  4800  457.5  50    16.6  4800  450.3  50    16.5  4742  443.9  49    18.0  4771  446.1  49    16.2  4776  430.4  49
 61  17.8  3574               17.6  3574               18.0  3517               19.1  3485               18.2  3427           
 62  18.0  4686  466.1  50    17.8  4688  460.7  50    17.9  4679  453.2  49    18.9  4621  456.9  49    17.7  4517  443.6  48
 65  17.9  3614               17.2  3650               17.6  3519               17.9  3577               17.2  3456           
 66  17.0  4746  468.3  50    17.3  4659  461.1  50    17.5  4536  456.8  49    18.1  4474  464.2  49    18.0  4515  446.9  48
 69  17.2  3482               17.0  3387               15.9  3350               17.2  3434               17.2  3264           
 70  16.6  4922  467.7  50    16.6  4710  460.8  48    15.9  4694  452.5  48    16.5  4759  459.2  49    16.4  4600  443.0  47
 73  17.7  3339               17.4  3423               17.6  3391               17.8  3475               17.7  3266           
 74  15.6  4625  470.7  48    17.1  4571  456.2  48    16.5  4624  454.7  48    17.0  4705  458.8  49    17.0  4334  448.5  46
 77  16.1  3369               16.7  3384               16.7  3393               16.5  3531               16.4  3332           
 78  15.8  4683  474.9  46    16.9  4745  457.6  48    16.4  4670  449.4  48    16.9  4642  455.8  48    16.3  4398  441.7  45
 81  15.3  3249               15.8  3565               16.0  3503               16.2  3572               15.9  3363           
 82  15.8  4028  475.7  42    16.3  4638  456.4  48    16.5  4499  446.8  46    16.1  4678  451.6  48    15.9  4294  437.8  45
 85  15.2  3030               15.1  3474               14.8  3304               14.9  3373               16.4  3236           
 86  14.9  3881  471.0  41    14.7  4573  444.2  48    15.7  4391  438.5  45    14.8  4445  441.1  46    16.1  4193  433.6  44
 89  16.0  2878               16.3  3240               17.8  3123               16.9  3271               17.0  2952           
 90  16.8  3735  462.4  39    16.8  4256  442.3  45    17.5  4034  431.5  42    17.6  3840  439.8  44    16.6  3888  429.8  40
 93  16.4  2507               16.6  2930               16.5  2800               17.3  2874               16.8  2535           
 94  14.0  3416  448.1  34    15.7  4159  425.3  42    16.7  3697  426.8  38    16.3  4017  422.6  41    16.8  3515  419.9  36
 97  17.8  2159               16.9  2580               17.4  2557               18.1  2731               18.8  2423           
==================================================================================================================================
                                              DIAGNOSTIC TRAILER REPORT
                                              FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE
                                              CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
           0 PPM                   469 PPM                  938 PPM                  1875 PPM                 3750 PPM
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS
===================================================================================================================================
 98  16.1  2995  449.8  30    17.0  3202  429.0  33    16.1  3503  424.8  35    17.0  3690  418.2  38    16.9  3109  413.8  32
101  14.4  1972               14.8  2422               14.3  2417               15.5  2506               15.8  1821           
102  14.8  2383  430.3  25    15.2  2851  405.3  29    15.4  2652  399.6  28    17.7  2890  414.2  31    16.4  2179  401.9  23

MEAN BODY WGT FOR WEEKS
1 TO 13          203.7                    200.2                    199.3                    197.3                    194.7
14 TO 52         402.5                    401.1                    395.1                    397.1                    392.9
 > 52            460.7                    445.6                    439.7                    443.8                    432.0
==================================================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
                                              DIAGNOSTIC TRAILER REPORT
                                              FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
                                              CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
           0 PPM                   469 PPM                  938 PPM                  1875 PPM                 3750 PPM
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
===================================================================================================================================
  B              100.7  60                101.3  50                102.0  50                100.3  50                101.6  60
  1  11.3  4164  100.7  60    11.7  3470  101.3  50    10.9  3472  102.0  50    10.4  3470  100.3  50    10.2  4164  101.6  60
  2  11.3  5660  118.3  60    11.5  4730  118.7  50    10.7  4716  117.4  50    10.5  4760  116.0  50    11.0  5671  117.3  60
  5  11.3  4302               11.3  3580               11.1  3575               11.1  3570               11.0  4278           
  6  10.8  5773  164.6  60    10.9  4765  160.6  50    11.1  4820  156.0  50    10.9  4820  156.1  50    10.9  5727  156.7  60
  9  11.1  4026               11.1  3360               10.9  3355                9.6  3360               10.9  4038           
 10   8.9  5845  181.8  60     9.4  4896  176.3  50     9.9  4917  171.3  50    10.3  4929  168.7  50     9.1  6029  165.8  60
 13  10.2  4470               10.0  3715               10.2  3649               10.4  3721                9.9  4464           
 14  11.1  5658  195.4  60    11.0  4755  186.8  50    10.2  4655  182.3  49    10.6  4765  184.7  50    10.6  5768  176.7  60
 17  10.4  4046               10.5  3655                9.2  3592                9.5  3668                9.8  4002           
 18  10.3  5230  207.6  55    10.7  4694  198.7  50     9.1  4663  187.3  49     9.2  4767  190.5  50    10.2  5165  184.2  55
 21   9.3  3876               10.0  3553                9.7  3450                9.4  3516                9.9  3905           
 22   9.8  5314  215.1  55     9.1  4830  201.8  50     9.8  4773  195.2  49     8.8  4923  191.8  50     9.8  5365  191.1  55
 25  10.3  3982                9.3  3594                9.2  3550                8.8  3606                9.4  3962           
 26   9.7  5137  226.4  55     9.5  4853  209.7  50     9.6  4612  202.6  49     9.2  4777  198.9  50     9.4  5339  194.6  55
 29  10.3  4119                9.1  3732                9.1  3678                9.3  3746                9.5  4119           
 30  10.6  5324  231.2  55     9.4  4865  213.2  50     9.8  4741  206.4  49     9.7  4834  203.2  50     9.9  5320  197.2  55
 33   9.9  3832               10.0  3573                9.7  3420                9.4  3490               10.1  3951           
 34   9.9  5351  238.0  55    10.1  4855  218.2  50     9.4  4762  209.1  49     9.4  4860  204.8  50    10.1  5305  201.5  55
 37  10.5  4036                9.6  3657                9.8  3605                9.9  3673                9.9  3673           
 38  10.5  5377  241.6  55     8.9  4974  213.0  50    10.2  4761  208.8  49     9.7  4845  205.4  50     9.5  5494  198.7  55
 41  10.9  4001               10.2  3660                9.7  3547                9.3  3620               10.0  3999           
 42  10.3  4896  249.7  55    10.3  4353  225.8  50     9.7  4239  213.5  49    10.0  4339  209.6  50    10.0  4364  204.0  55
 45  11.3  4037                9.4  3670               11.0  3597               10.0  3669                9.9  4042           
 46  10.3  5216  260.7  55    10.7  4632  232.0  50     9.9  4668  219.0  49    10.2  4782  213.0  50    10.4  5116  208.6  55
 49   9.7  3808               10.3  3435                9.9  3388                9.9  3445               11.0  3782           
 50   9.8  4797  261.1  55    10.3  4305  233.1  50    10.0  4244  219.4  49    10.1  4820  214.0  50    10.6  5274  211.0  55
 53  10.4  3534               10.1  3535               10.6  3479                9.5  3591               10.6  3594           
 54  11.9  4945  268.5  50    10.7  4913  238.9  50    11.2  4799  221.7  49    10.7  4851  218.8  50    10.6  4835  214.0  50
 57  11.4  3193               10.7  3555               11.4  3485               10.2  3550               11.3  3569           
 58  11.3  4348  270.7  50    10.5  4892  246.8  50    10.7  4739  230.2  49    10.7  4794  225.0  50    11.0  4892  221.8  50
 61  12.4  3627               11.9  3610               11.8  3489               11.5  3615               12.0  3545           
 62  12.2  4758  293.1  50    12.1  4711  261.4  50    11.4  4679  242.9  49    10.9  4731  234.5  50    11.5  4880  233.5  50
 65  11.9  3600               12.0  3600               11.9  3530               11.5  3581               11.5  3584           
 66  11.8  4836  302.4  50    11.3  4932  267.2  50    10.9  4704  252.0  49    11.5  4673  245.4  50    11.0  4801  238.3  50
 69  11.8  3612               11.7  3610               11.1  3636               11.3  3710               11.5  3714           
 70  11.2  4765  311.4  50    11.5  4931  273.2  50    11.1  4613  257.7  49    10.6  4649  250.5  50    11.0  4818  248.7  50
 73  11.4  3662               12.0  3569               11.1  3444               12.5  3566               11.9  3487           
 74  11.4  4769  318.4  50    11.3  4809  281.2  50    12.4  4548  269.6  48    12.0  4730  261.8  50    11.3  4692  257.9  49
 77  11.1  3643               10.9  3582               11.1  3434               11.1  3587               10.7  3577           
 78  10.8  4825  319.7  50    11.3  4708  284.9  49    10.8  4628  271.7  48    11.1  4825  267.2  50    11.6  4429  261.9  48
 81  11.3  3293               11.9  3292               11.0  3226               11.0  3293               11.4  3228           
 82  10.9  4925  321.9  49    11.9  4834  289.6  49    10.7  4818  275.0  48    10.5  4935  272.5  49    11.1  4765  264.2  48
 85  12.6  3245               10.8  3318               12.2  3178               11.7  3461               12.1  3395           
 86  11.6  4462  330.2  46    11.2  4503  290.2  46    11.0  4407  279.5  45    11.2  4654  276.5  49    11.5  4710  268.1  48
 89  12.1  3102               12.7  3321               11.9  3317               11.8  3553               11.8  3440           
 90  11.8  4124  335.4  43    11.9  4315  298.5  45    11.4  4031  282.5  45    11.4  4588  280.8  48    11.6  4577  275.2  48
 93  12.1  2769               13.0  2974               11.8  2977               12.6  3103               12.1  3342           
 94  11.7  3749  337.9  39    12.6  4186  299.0  43    11.4  4247  280.5  43    10.1  4400  274.1  44    11.5  4819  271.1  48
 97  11.7  2507               12.5  3086               13.1  2657               12.6  3137               12.3  3445           
==================================================================================================================================
                                              DIAGNOSTIC TRAILER REPORT
                                              FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
                                              CHRONIC DOSED FEED STUDY OF ANTHRAQUINONE
==================================================================================================================================
           0 PPM                   469 PPM                  938 PPM                  1875 PPM                 3750 PPM
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS
===================================================================================================================================
 98  12.0  3198  345.4  33    12.0  4138  306.0  42    12.2  3881  295.5  40    12.7  4116  287.6  43    12.0  4646  276.8  48
101  11.3  2114               11.7  2885               11.2  2769               12.0  2888               11.0  3239           
102  12.0  2730  342.5  28    11.6  3994  305.0  41    10.9  3698  290.2  38    11.1  3895  284.4  40    10.9  4462  271.9  46

MEAN BODY WGT FOR WEEKS
1 TO 13          141.3                    139.2                    136.7                    135.3                    135.4
14 TO 52         232.7                    213.2                    204.4                    201.6                    196.8
 > 52            315.2                    280.1                    265.3                    259.9                    254.1
==================================================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.