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TDMS Study 88036-03 Pathology Tables

NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                                  ANTHRAQUINONE                                             DATE: 02/25/99    
EXPERIMENT: 88036 TEST: 03                                                                                        TIME: 11:19:30    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88036      
CONT: N01-ES-25337                                                                                                CAS: 84-65-1      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41

LAB: BATTELLE COLUMBUS LABORATORY                     ANTHRAQUINONE                                               DATE: 02/25/99


EXPERIMENT: 88036 TEST: 03                                                                                        TIME: 11:28:58



TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  C88036

CONT: N01-ES-25337                                                                                                CAS: 84-65-1

                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
                                             TWO YEAR DOSED FEED STUDY OF ANTHRAQUINONE

===================================================================================================================================
WEEK     0 PPM                  469 PPM                  938 PPM                  1875 PPM                 3750 PPM
         ----------------       ----------------         ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
==================================================================================================================================

  B       112.8       60       112.2     99.5    50     114.2    101.2    50     112.6     99.8    50     112.5     99.7    60
  1       112.8       60       112.2     99.5    50     114.2    101.2    50     112.6     99.8    50     112.5     99.7    60
  2       149.0       60       148.0     99.3    50     148.6     99.7    50     148.1     99.4    50     144.9     97.2    60
  6       252.2       60       246.0     97.5    50     241.2     95.6    50     242.0     96.0    50     236.6     93.8    60
 10       300.8       60       294.4     97.9    50     293.1     97.4    50     286.4     95.2    50     284.7     94.6    59
 14       335.9       60 (I)   328.5     97.8    50     323.3     96.2    50     316.9     94.3    50     321.6     95.7    59 (I)
 18       360.9       55       354.3     98.2    50     346.1     95.9    50     348.6     96.6    50     348.0     96.4    54
 22       378.6       55       372.8     98.5    50     366.6     96.8    50     370.4     97.8    50     365.9     96.6    54
 26       395.1       55       392.9     99.4    50     389.2     98.5    50     389.9     98.7    50     383.2     97.0    54
 30       408.5       55       407.4     99.7    50     404.1     98.9    50     405.3     99.2    50     399.6     97.8    54
 34       416.2       55       419.1    100.7    50     413.8     99.4    50     414.3     99.5    50     408.6     98.2    54
 38       423.0       55       425.4    100.6    50     418.3     98.9    50     419.7     99.2    49     416.6     98.5    54
 42       429.8       55       432.4    100.6    50     422.5     98.3    50     428.9     99.8    49     426.2     99.2    54
 46       436.3       55       440.0    100.8    50     433.1     99.3    49     439.6    100.8    49     430.7     98.7    54
 50       440.9       55       438.6     99.5    50     433.8     98.4    49     437.3     99.2    49     428.7     97.2    54
 54       446.6       50 (I)   443.2     99.2    50     437.6     98.0    49     440.4     98.6    49     424.6     95.1    49 (I)
 58       457.5       50       450.3     98.4    50     443.9     97.0    49     446.1     97.5    49     430.4     94.1    49
 62       466.1       50       460.7     98.8    50     453.2     97.2    49     456.9     98.0    49     443.6     95.2    48
 66       468.3       50       461.1     98.5    50     456.8     97.5    49     464.2     99.1    49     446.9     95.4    48
 70       467.7       50       460.8     98.5    48     452.5     96.8    48     459.2     98.2    49     443.0     94.7    47
 74       470.7       48       456.2     96.9    48     454.7     96.6    48     458.8     97.5    49     448.5     95.3    46
 78       474.9       46       457.6     96.4    48     449.4     94.6    48     455.8     96.0    48     441.7     93.0    45
 82       475.7       42       456.4     95.9    48     446.8     93.9    46     451.6     94.9    48     437.8     92.0    45
 86       471.0       41       444.2     94.3    48     438.5     93.1    45     441.1     93.7    46     433.6     92.1    44
 90       462.4       39       442.3     95.7    45     431.5     93.3    42     439.8     95.1    44     429.8     92.9    40
 94       448.1       34       425.3     94.9    42     426.8     95.2    38     422.6     94.3    41     419.9     93.7    36
 98       449.8       30       429.0     95.4    33     424.8     94.4    35     418.2     93.0    38     413.8     92.0    32
102       430.3       25       405.3     94.2    29     399.6     92.9    28     414.2     96.3    31     401.9     93.4    23

TERM. SAC.            22                         23                       22                       26                       22


===================================================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.

                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
                                             TWO YEAR DOSED FEED STUDY OF ANTHRAQUINONE

===================================================================================================================================
WEEK     0 PPM                  469 PPM                  938 PPM                  1875 PPM                 3750 PPM
         ----------------       ----------------         ----------------         ----------------         ----------------
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)
==================================================================================================================================

  B       100.7       60       101.3    100.6    50     102.0    101.3    50     100.3     99.6    50     101.6    100.9    60
  1       100.7       60       101.3    100.6    50     102.0    101.3    50     100.3     99.6    50     101.6    100.9    60
  2       118.3       60       118.7    100.3    50     117.4     99.2    50     116.0     98.1    50     117.3     99.2    60
  6       164.6       60       160.6     97.6    50     156.0     94.8    50     156.1     94.8    50     156.7     95.2    60
 10       181.8       60       176.3     97.0    50     171.3     94.2    50     168.7     92.8    50     165.8     91.2    60
 14       195.4       60 (I)   186.8     95.6    50     182.3     93.3    49     184.7     94.5    50     176.7     90.4    60 (I)
 18       207.6       55       198.7     95.7    50     187.3     90.2    49     190.5     91.8    50     184.2     88.7    55
 22       215.1       55       201.8     93.8    50     195.2     90.7    49     191.8     89.2    50     191.1     88.8    55
 26       226.4       55       209.7     92.6    50     202.6     89.5    49     198.9     87.9    50     194.6     86.0    55
 30       231.2       55       213.2     92.2    50     206.4     89.3    49     203.2     87.9    50     197.2     85.3    55
 34       238.0       55       218.2     91.7    50     209.1     87.9    49     204.8     86.1    50     201.5     84.7    55
 38       241.6       55       213.0     88.2    50     208.8     86.4    49     205.4     85.0    50     198.7     82.2    55
 42       249.7       55       225.8     90.4    50     213.5     85.5    49     209.6     83.9    50     204.0     81.7    55
 46       260.7       55       232.0     89.0    50     219.0     84.0    49     213.0     81.7    50     208.6     80.0    55
 50       261.1       55       233.1     89.3    50     219.4     84.0    49     214.0     82.0    50     211.0     80.8    55
 54       268.5       50 (I)   238.9     89.0    50     221.7     82.6    49     218.8     81.5    50     214.0     79.7    50 (I)
 58       270.7       50       246.8     91.2    50     230.2     85.0    49     225.0     83.1    50     221.8     81.9    50
 62       293.1       50       261.4     89.2    50     242.9     82.9    49     234.5     80.0    50     233.5     79.7    50
 66       302.4       50       267.2     88.4    50     252.0     83.3    49     245.4     81.2    50     238.3     78.8    50
 70       311.4       50       273.2     87.7    50     257.7     82.8    49     250.5     80.4    50     248.7     79.9    50
 74       318.4       50       281.2     88.3    50     269.6     84.7    48     261.8     82.2    50     257.9     81.0    49
 78       319.7       50       284.9     89.1    49     271.7     85.0    48     267.2     83.6    50     261.9     81.9    48
 82       321.9       49       289.6     90.0    49     275.0     85.4    48     272.5     84.7    49     264.2     82.1    48
 86       330.2       46       290.2     87.9    46     279.5     84.6    45     276.5     83.7    49     268.1     81.2    48
 90       335.4       43       298.5     89.0    45     282.5     84.2    45     280.8     83.7    48     275.2     82.1    48
 94       337.9       39       299.0     88.5    43     280.5     83.0    43     274.1     81.1    44     271.1     80.2    48
 98       345.4       33       306.0     88.6    42     295.5     85.6    40     287.6     83.3    43     276.8     80.1    48
102       342.5       28       305.0     89.1    41     290.2     84.7    38     284.4     83.0    40     271.9     79.4    46

TERM. SAC.            23                         40                       35                       37                       40


===================================================================================================================================


    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.