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https://ntp.niehs.nih.gov/go/4764

TDMS Study 88036-03 Pathology Tables

NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99
Route: DOSED FEED                                                                                                 Time: 11:42:20

                                                      2 YEAR CHRONIC RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  84-65-1

       Lock Date:  07/23/97

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14            7           12            7            6                        
    Natural Death                                     13            3            3            6            4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           40           35           37           40                        

  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (50)         (49)                      
      Parasite Metazoan                                             2 (4%)       2 (4%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (49)         (50)         (50)                      
      Inflammation                                                               1 (2%)                                             
      Parasite Metazoan                                6 (12%)     11 (22%)      2 (4%)       8 (16%)                               
   Intestine Large, Cecum                             (50)         (49)         (49)         (50)         (49)                      
      Inflammation                                                                            1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (49)                      
      Inflammation                                                                            1 (2%)                                
   Intestine Small, Ileum                             (50)         (49)         (49)         (50)         (49)                      
      Cyst                                                                       1 (2%)                                             
      Inflammation                                                                            1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)         (49)                      
      Angiectasis                                      3 (6%)      15 (30%)     18 (36%)     15 (30%)     21 (43%)                  
      Basophilic Focus                                37 (74%)     50 (100%)    34 (68%)     33 (66%)     15 (31%)                  
      Clear Cell Focus                                 1 (2%)       3 (6%)       2 (4%)       6 (12%)      3 (6%)                   
      Degeneration, Cystic                                          5 (10%)     10 (20%)     10 (20%)      6 (12%)                  
      Eosinophilic Focus                               8 (16%)     32 (64%)     34 (68%)     39 (78%)     34 (69%)                  
      Fatty Change                                     1 (2%)                                                                       
      Fibrosis                                                                                             1 (2%)                   
      Hematopoietic Cell Proliferation                 3 (6%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       5 (10%)     10 (20%)      7 (14%)      6 (12%)      5 (10%)                  
      Inflammation                                    25 (50%)     46 (92%)     44 (88%)     38 (76%)     46 (94%)                  
      Mixed Cell Focus                                 3 (6%)      30 (60%)     20 (40%)     23 (46%)     13 (27%)                  
      Necrosis                                         4 (8%)       4 (8%)       5 (10%)      6 (12%)      3 (6%)                   
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Vacuolization Cytoplasmic                        5 (10%)      4 (8%)       6 (12%)      4 (8%)       4 (8%)                   
      Bile Duct, Cholangiofibrosis                                               1 (2%)       1 (2%)                                
      Bile Duct, Cyst                                               1 (2%)                    1 (2%)       2 (4%)                   
      Bile Duct, Hyperplasia                          17 (34%)     22 (44%)     20 (40%)     20 (40%)     12 (24%)                  
      Centrilobular, Degeneration                      1 (2%)       1 (2%)       1 (2%)                    1 (2%)                   
      Centrilobular, Hypertrophy                                   18 (36%)     23 (46%)     19 (38%)     26 (53%)                  
      Centrilobular, Necrosis                                                                 1 (2%)                                
   Mesentery                                          (4)          (4)          (6)          (3)          (2)                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                                               1 (17%)                                            
      Fat, Necrosis                                    3 (75%)      4 (100%)     4 (67%)      2 (67%)      2 (100%)                 
   Oral Mucosa                                        (1)                       (1)                                                 
      Gingival, Inflammation                           1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)         (49)                      
      Atrophy                                         21 (42%)     27 (54%)     16 (32%)     22 (44%)      9 (18%)                  
      Hyperplasia                                      2 (4%)       1 (2%)                    2 (4%)       1 (2%)                   
      Hypertrophy, Focal                               1 (2%)       2 (4%)                                 1 (2%)                   
      Metaplasia, Hepatocyte                                                                  1 (2%)       1 (2%)                   
      Pigmentation                                                               1 (2%)                                             
      Artery, Inflammation                                                                                 1 (2%)                   
      Duct, Cyst                                                                                           1 (2%)                   
   Salivary Glands                                    (50)         (50)         (50)         (50)         (48)                      
      Atrophy                                                       1 (2%)                                 1 (2%)                   
      Fibrosis                                                      1 (2%)                                                          
      Inflammation                                     1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (49)                      
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                                                                       
      Foreign Body                                                               1 (2%)                                             
      Hyperplasia                                      4 (8%)       1 (2%)       2 (4%)       2 (4%)       2 (4%)                   
      Inflammation                                     1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                            6 (12%)                   1 (2%)       3 (6%)       1 (2%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (49)                      
      Edema                                                                      1 (2%)                                             
      Erosion                                          2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation                                                                                         1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
      Ulcer                                            2 (4%)       1 (2%)                                                          
   Tooth                                                                        (1)                                                 
      Inflammation                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (49)                      
      Inflammation                                     1 (2%)                                              1 (2%)                   
   Heart                                              (50)         (50)         (50)         (50)         (48)                      
      Cardiomyopathy                                  22 (44%)     25 (50%)     27 (54%)     28 (56%)     28 (58%)                  
      Inflammation                                     2 (4%)       9 (18%)      4 (8%)       1 (2%)       3 (6%)                   
      Artery, Inflammation                                          2 (4%)                                                          
      Atrium, Thrombosis                               2 (4%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (49)                      
      Degeneration, Cystic                             6 (12%)      2 (4%)       6 (12%)      9 (18%)      3 (6%)                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     13 (26%)     12 (24%)     17 (34%)     17 (34%)      3 (6%)                   
      Hypertrophy                                      3 (6%)       1 (2%)       1 (2%)       7 (14%)      5 (10%)                  
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                                                                             1 (2%)                   
      Vacuolization Cytoplasmic                        1 (2%)       2 (4%)       1 (2%)       4 (8%)       3 (6%)                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (49)                      
      Cyst                                                                                                 1 (2%)                   
      Hyperplasia                                      8 (16%)      3 (6%)       4 (8%)       4 (8%)       6 (12%)                  
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)         (49)                      
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (44)         (48)         (48)         (41)                      
      Hyperplasia                                                   1 (2%)                                 1 (2%)                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)         (50)         (49)         (49)                      
      Angiectasis                                      1 (2%)      12 (24%)      2 (4%)      10 (20%)      6 (12%)                  
      Cyst                                             9 (18%)      7 (14%)      3 (6%)                    3 (6%)                   
      Degeneration                                     1 (2%)                                              1 (2%)                   
      Pars Distalis, Hyperplasia                      24 (48%)     27 (54%)     21 (42%)     26 (53%)     32 (65%)                  
      Pars Intermedia, Hyperplasia                                  1 (2%)                                 1 (2%)                   
      Pars Nervosa, Hyperplasia                                                               1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)         (49)                      
      C-Cell, Hyperplasia                             21 (42%)     29 (58%)     20 (40%)     18 (36%)     18 (37%)                  
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (46)         (48)         (49)         (48)                      
      Hyperplasia                                      2 (4%)       5 (11%)      8 (17%)      4 (8%)       3 (6%)                   
      Inflammation                                    10 (20%)     21 (46%)     13 (27%)     11 (22%)     12 (25%)                  
      Duct, Cyst                                       4 (8%)       5 (11%)      2 (4%)       4 (8%)       3 (6%)                   
   Ovary                                              (50)         (50)         (50)         (50)         (49)                      
      Atrophy                                                                                              1 (2%)                   
      Cyst                                             5 (10%)      8 (16%)      9 (18%)      8 (16%)      6 (12%)                  
      Granulosa Cell, Hyperplasia                      1 (2%)       1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Oviduct                                                         (1)          (1)                                                 
      Inflammation                                                  1 (100%)                                                        
   Uterus                                             (50)         (50)         (50)         (50)         (49)                      
      Angiectasis                                                                1 (2%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia                                                   3 (6%)       3 (6%)       3 (6%)       4 (8%)                   
      Inflammation                                     1 (2%)                                                                       
      Cervix, Hypertrophy                                                                                  1 (2%)                   
      Cervix, Inflammation                                                       1 (2%)                    1 (2%)                   
   Vagina                                             (1)                                                 (1)                       
      Cyst, Squamous                                                                                       1 (100%)                 
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          4 (8%)      13 (26%)     13 (26%)     11 (22%)     13 (26%)                  
      Hyperplasia                                     19 (38%)     31 (62%)     28 (56%)     19 (38%)     23 (46%)                  
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation                                                                                         1 (2%)                   
   Lymph Node, Mandibular                             (49)         (49)         (50)         (48)         (47)                      
      Ectasia                                          2 (4%)                    2 (4%)       1 (2%)                                
      Hyperplasia, Plasma Cell                                      1 (2%)       1 (2%)                    1 (2%)                   
      Inflammation                                                               1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (50)         (49)                      
      Atrophy                                          1 (2%)       1 (2%)                                 1 (2%)                   
      Ectasia                                          1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)         (49)                      
      Congestion                                       1 (2%)      46 (92%)     42 (84%)     44 (88%)     45 (92%)                  
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                39 (78%)     50 (100%)    47 (94%)     47 (94%)     46 (94%)                  
      Infarct                                          1 (2%)                                 1 (2%)                                
      Pigmentation                                    33 (66%)     45 (90%)     48 (96%)     48 (96%)     47 (96%)                  
      Capsule, Fibrosis                                2 (4%)                    1 (2%)       1 (2%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)                    2 (4%)       3 (6%)                                
      Red Pulp, Depletion Cellular                                  1 (2%)       2 (4%)       2 (4%)                                
   Thymus                                             (46)         (48)         (48)         (49)         (46)                      
      Atrophy                                         44 (96%)     48 (100%)    47 (98%)     49 (100%)    46 (100%)                 
      Artery, Inflammation                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Cyst                                             5 (10%)      3 (6%)       4 (8%)       2 (4%)       1 (2%)                   
      Hyperplasia                                     23 (46%)      8 (16%)     11 (22%)      5 (10%)      5 (10%)                  
      Inflammation                                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Acanthosis                                                                              1 (2%)                                
      Cyst Epithelial Inclusion                                                                            1 (2%)                   
      Ulcer                                            1 (2%)                                                                       
      Hair Follicle, Atrophy                                        1 (2%)                                                          
      Subcutaneous Tissue, Necrosis                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Fibrous Osteodystrophy                                                     1 (2%)                                             
      Osteopetrosis                                    3 (6%)       2 (4%)       3 (6%)       1 (2%)                                
      Osteoporosis                                                                            1 (2%)                                
      Maxilla, Cyst                                                                           1 (2%)                                
      Maxilla, Inflammation                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (49)                      
      Gliosis                                                                                              1 (2%)                   
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation                                     1 (2%)                                 1 (2%)       1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (48)                      
      Foreign Body                                                                                         1 (2%)                   
      Inflammation                                    13 (26%)     18 (36%)     19 (38%)     21 (42%)     24 (50%)                  
      Pigmentation                                    44 (88%)     50 (100%)    48 (96%)     47 (94%)     48 (100%)                 
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (6%)       7 (14%)      2 (4%)       5 (10%)                               
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Foreign Body                                     4 (8%)       1 (2%)       1 (2%)                    1 (2%)                   
      Inflammation                                     4 (8%)       2 (4%)       1 (2%)       1 (2%)       1 (2%)                   
      Nasolacrimal Duct, Inflammation                  1 (2%)                                                                       
      Respiratory Epithelium, Inflammation                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)          (3)          (5)                       
      Cataract                                         2 (100%)     3 (100%)     1 (50%)      2 (67%)      3 (60%)                  
      Degeneration                                                               1 (50%)      2 (67%)      2 (40%)                  
      Hemorrhage                                                                                           1 (20%)                  
      Inflammation                                                               1 (50%)                                            
      Cornea, Inflammation                             1 (50%)                                                                      
      Lens, Mineralization                                          2 (67%)      1 (50%)                                            
      Retina, Degeneration                             1 (50%)      3 (100%)     2 (100%)     1 (33%)      3 (60%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (49)                      
      Accumulation, Hyaline Droplet                   33 (66%)     48 (96%)     45 (90%)     44 (88%)     44 (90%)                  
      Hydronephrosis                                                             2 (4%)                    1 (2%)                   
      Infarct                                          1 (2%)                    1 (2%)                                             
      Inflammation                                     3 (6%)                                                                       
      Nephropathy                                     39 (78%)     49 (98%)     47 (94%)     49 (98%)     49 (100%)                 
      Pigmentation                                    27 (54%)     50 (100%)    48 (96%)     50 (100%)    47 (96%)                  
      Medulla, Mineralization                         17 (34%)     25 (50%)     27 (54%)     28 (56%)     20 (41%)                  
      Pelvis, Calculus Micro Observation Only          1 (2%)                                                                       
      Pelvis, Inflammation                                          1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                                    12 (24%)     13 (26%)     15 (30%)     11 (22%)                  
      Renal Tubule, Hyperplasia, Oncocytic                          2 (4%)                    1 (2%)       1 (2%)                   
      Transitional Epithelium, Hyperplasia                          5 (10%)     12 (24%)      3 (6%)      10 (20%)                  
   Urinary Bladder                                    (49)         (49)         (49)         (50)         (49)                      
      Calculus Micro Observation Only                                                         1 (2%)                                
      Inflammation                                    13 (27%)     16 (33%)      9 (18%)     25 (50%)     17 (35%)                  
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)       4 (8%)       4 (8%)                   
      Transitional Epithelium, Metaplasia, Squamous                                           1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           21           16           14           17                        
    Natural Death                                      7            6           12           10           11                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           23           22           26           22                        
    Natural Death                                      1                                                                            

  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (49)                      
      Inflammation                                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)         (50)         (50)                      
      Edema                                                                                   1 (2%)                                
      Inflammation                                                                            1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (2%)                                             
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)         (50)                      
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                5 (10%)      7 (14%)      7 (14%)      5 (10%)      3 (6%)                   
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (49)                      
      Edema                                            1 (2%)                                                                       
      Inflammation                                     2 (4%)                                              2 (4%)                   
      Mineralization                                                                                       1 (2%)                   
      Artery, Inflammation                                                                    1 (2%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
      Erosion                                                       1 (2%)       1 (2%)                    1 (2%)                   
      Inflammation                                                                                         2 (4%)                   
      Ulcer                                            2 (4%)       1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                                                         1 (2%)                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)         (50)                      
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                      6 (12%)     21 (42%)     13 (26%)      9 (18%)      9 (18%)                  
      Basophilic Focus                                25 (50%)     35 (70%)     35 (70%)     32 (64%)     23 (46%)                  
      Clear Cell Focus                                 9 (18%)      5 (10%)      6 (12%)      8 (16%)      5 (10%)                  
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                             9 (18%)     31 (62%)     36 (72%)     28 (56%)     29 (58%)                  
      Eosinophilic Focus                               9 (18%)     22 (44%)     30 (60%)     29 (58%)     20 (40%)                  
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       3 (6%)       3 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hemorrhage                                                                              1 (2%)                                
      Hepatodiaphragmatic Nodule                       5 (10%)      9 (18%)      2 (4%)       5 (10%)      4 (8%)                   
      Inflammation                                    13 (26%)     30 (60%)     28 (56%)     30 (60%)     27 (54%)                  
      Mineralization                                                                          1 (2%)                                
      Mixed Cell Focus                                 4 (8%)      12 (24%)     15 (30%)     13 (26%)     10 (20%)                  
      Necrosis                                         5 (10%)      5 (10%)      5 (10%)      7 (14%)      5 (10%)                  
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                       1 (2%)       1 (2%)                                 1 (2%)                   
      Vacuolization Cytoplasmic                        5 (10%)     18 (36%)     23 (46%)     17 (34%)     23 (46%)                  
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                          48 (96%)     50 (100%)    47 (94%)     49 (98%)     47 (94%)                  
      Centrilobular, Degeneration                      2 (4%)       2 (4%)       2 (4%)       1 (2%)       2 (4%)                   
      Centrilobular, Hypertrophy                                    4 (8%)      21 (42%)     13 (26%)     29 (58%)                  
      Centrilobular, Necrosis                                       1 (2%)                    2 (4%)       1 (2%)                   
   Mesentery                                          (10)         (4)          (6)          (7)          (6)                       
      Inflammation                                     2 (20%)                                                                      
      Artery, Inflammation                                                                    1 (14%)                               
      Artery, Mineralization                                                                               2 (33%)                  
      Fat, Inflammation                                                                       1 (14%)                               
      Fat, Necrosis                                    6 (60%)      3 (75%)      2 (33%)      2 (29%)      4 (67%)                  
   Oral Mucosa                                        (1)                       (2)                       (1)                       
      Pharyngeal, Hyperplasia                                                    1 (50%)                                            
   Pancreas                                           (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                         26 (52%)     30 (60%)     25 (50%)     28 (56%)     24 (48%)                  
      Hyperplasia                                      2 (4%)       4 (8%)       2 (4%)       2 (4%)       1 (2%)                   
      Hypertrophy, Focal                               1 (2%)       6 (12%)      3 (6%)       2 (4%)       2 (4%)                   
      Inflammation                                                  2 (4%)       2 (4%)       1 (2%)                                
      Artery, Hypertrophy                                                                                  1 (2%)                   
      Artery, Inflammation                             1 (2%)       1 (2%)       3 (6%)       1 (2%)       5 (10%)                  
      Artery, Mineralization                                                                  1 (2%)       3 (6%)                   
      Duct, Cyst                                                                                           1 (2%)                   
      Duct, Hyperplasia                                1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (48)         (50)         (47)                      
      Atrophy                                          1 (2%)       3 (6%)                                 1 (2%)                   
      Hyperplasia                                                                1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
      Mineralization                                                                          1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (50)                      
      Edema                                            2 (4%)       4 (8%)       2 (4%)       2 (4%)       3 (6%)                   
      Foreign Body                                     1 (2%)                                                                       
      Hyperplasia                                      4 (8%)      11 (22%)      7 (14%)      4 (8%)       4 (8%)                   
      Inflammation                                     4 (8%)                    2 (4%)                    1 (2%)                   
      Mineralization                                                                          2 (4%)       4 (8%)                   
      Perforation                                                   1 (2%)       1 (2%)                                             
      Ulcer                                            3 (6%)       8 (16%)      4 (8%)                    3 (6%)                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (50)                      
      Erosion                                          2 (4%)       4 (8%)       1 (2%)       2 (4%)       1 (2%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Hyperplasia                                                                                          1 (2%)                   
      Inflammation                                     1 (2%)                    1 (2%)       1 (2%)       1 (2%)                   
      Mineralization                                   2 (4%)       4 (8%)       7 (14%)     10 (20%)     10 (20%)                  
      Ulcer                                            3 (6%)       2 (4%)       3 (6%)       1 (2%)       3 (6%)                   
   Tooth                                                                                                  (1)                       
      Inflammation                                                                                         1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)         (50)                      
      Mineralization                                   3 (6%)       3 (6%)       4 (8%)       7 (14%)      7 (14%)                  
      Aorta, Aneurysm                                                                                      1 (2%)                   
   Heart                                              (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                                1 (2%)                                             
      Cardiomyopathy                                  42 (84%)     44 (88%)     44 (88%)     43 (86%)     41 (82%)                  
      Inflammation                                                  1 (2%)       1 (2%)       2 (4%)       1 (2%)                   
      Mineralization                                   1 (2%)       2 (4%)       4 (8%)       5 (10%)      5 (10%)                  
      Artery, Inflammation                                          1 (2%)                                 1 (2%)                   
      Atrium, Thrombosis                               6 (12%)                   1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Degeneration, Cystic                             7 (14%)      4 (8%)       3 (6%)       7 (14%)      9 (18%)                  
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)       2 (4%)                                
      Hyperplasia                                      8 (16%)     10 (20%)      8 (16%)     13 (26%)      6 (12%)                  
      Hypertrophy                                      4 (8%)       1 (2%)       2 (4%)       4 (8%)       1 (2%)                   
      Necrosis                                                                                             1 (2%)                   
      Pigmentation                                     1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                    1 (2%)                   
      Vacuolization Cytoplasmic                        3 (6%)       2 (4%)                    1 (2%)       4 (8%)                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Angiectasis                                                                                          1 (2%)                   
      Hyperplasia                                     17 (34%)     24 (48%)     22 (44%)     20 (40%)     15 (30%)                  
      Thrombosis                                                                                           1 (2%)                   
   Parathyroid Gland                                  (49)         (48)         (48)         (50)         (45)                      
      Hyperplasia                                      5 (10%)     13 (27%)     19 (40%)     20 (40%)     12 (27%)                  
      Hyperplasia, Focal                               1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Inflammation                                                                                         1 (2%)                   
   Pituitary Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Angiectasis                                      1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Cyst                                             2 (4%)       3 (6%)       3 (6%)       3 (6%)       6 (12%)                  

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Thrombosis                                                                              1 (2%)                                
      Pars Distalis, Hyperplasia                      13 (26%)     26 (52%)     24 (49%)     28 (56%)     19 (38%)                  
      Pars Intermedia, Hyperplasia                                  1 (2%)                    2 (4%)       1 (2%)                   
      Pars Nervosa, Hyperplasia                        5 (10%)      1 (2%)                    4 (8%)       1 (2%)                   
   Thyroid Gland                                      (50)         (50)         (48)         (50)         (47)                      
      C-Cell, Hyperplasia                             14 (28%)     22 (44%)     14 (29%)     13 (26%)     12 (26%)                  
      Follicle, Cyst                                   3 (6%)       2 (4%)       3 (6%)       5 (10%)      4 (9%)                   
      Follicular Cell, Hyperplasia                     3 (6%)       3 (6%)       1 (2%)       1 (2%)       3 (6%)                   
      Follicular Cell, Hypertrophy                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                                                              
      Inflammation                                                  1 (100%)                                                        
   Epididymis                                         (50)         (50)         (50)         (50)         (50)                      
      Granuloma Sperm                                               1 (2%)                    3 (6%)       1 (2%)                   
      Inflammation                                                                            1 (2%)       1 (2%)                   
      Mineralization                                                1 (2%)                    1 (2%)       1 (2%)                   
   Preputial Gland                                    (50)         (49)         (50)         (49)         (50)                      
      Atrophy                                                                                              1 (2%)                   
      Hyperplasia                                      3 (6%)       4 (8%)       3 (6%)                    1 (2%)                   
      Infiltration Cellular                                                      1 (2%)                                             
      Inflammation                                    42 (84%)     34 (69%)     43 (86%)     37 (76%)     43 (86%)                  
      Duct, Ectasia                                    1 (2%)       4 (8%)       4 (8%)       4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)                                 1 (2%)                   
      Hyperplasia                                      1 (2%)                                 1 (2%)       1 (2%)                   
      Inflammation                                    33 (66%)     37 (74%)     36 (72%)     31 (62%)     34 (68%)                  
      Metaplasia, Squamous                                                       1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (49)         (50)                      
      Dilatation                                                                 2 (4%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation                                     1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Mineralization                                   1 (2%)                    1 (2%)       2 (4%)       3 (6%)                   
   Testes                                             (50)         (50)         (50)         (50)         (50)                      
      Atrophy                                          6 (12%)     10 (20%)      7 (14%)      6 (12%)      5 (10%)                  
      Thrombosis                                                                              1 (2%)                                
      Artery, Inflammation                             1 (2%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Interstitial Cell, Hyperplasia                  27 (54%)     27 (54%)     26 (52%)     24 (48%)     26 (52%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Hemorrhage                                       2 (4%)       2 (4%)                    1 (2%)       1 (2%)                   
      Hyperplasia                                     25 (50%)     28 (56%)     37 (74%)     36 (72%)     33 (66%)                  
      Myelofibrosis                                    1 (2%)                                 1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (8)          (3)          (1)          (1)          (2)                       
      Mediastinal, Ectasia                                                       1 (100%)                                           
      Mediastinal, Hematopoietic Cell Proliferation    1 (13%)                                                                      
      Mediastinal, Pigmentation                        1 (13%)                                                                      
      Renal, Hyperplasia, Plasma Cell                               1 (33%)                                                         
   Lymph Node, Mandibular                             (50)         (50)         (47)         (50)         (47)                      
      Atrophy                                                                                 1 (2%)       1 (2%)                   
      Ectasia                                          8 (16%)      2 (4%)       2 (4%)       1 (2%)       4 (9%)                   
      Hyperplasia, Plasma Cell                         3 (6%)       2 (4%)                    1 (2%)       3 (6%)                   
      Inflammation                                     1 (2%)       1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)         (49)                      
      Angiectasis                                                                             1 (2%)                                
      Atrophy                                          2 (4%)                    1 (2%)       1 (2%)       2 (4%)                   
      Ectasia                                          3 (6%)       5 (10%)      7 (14%)      7 (14%)      7 (14%)                  
      Hemorrhage                                       2 (4%)       1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)         (50)                      
      Accessory Spleen                                 1 (2%)                    1 (2%)                    1 (2%)                   
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       6 (12%)     35 (70%)     37 (74%)     30 (60%)     31 (62%)                  
      Fibrosis                                         5 (10%)                   3 (6%)       2 (4%)       2 (4%)                   
      Hematopoietic Cell Proliferation                37 (74%)     45 (90%)     44 (88%)     43 (86%)     39 (78%)                  
      Hemorrhage                                       2 (4%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular                                         2 (4%)                    1 (2%)       1 (2%)                   
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                    12 (24%)     36 (72%)     38 (76%)     33 (66%)     28 (56%)                  
      Capsule, Fibrosis                                1 (2%)                                                                       
      Capsule, Hyperplasia                                                                                 1 (2%)                   
      Lymphoid Follicle, Atrophy                       1 (2%)                    2 (4%)       2 (4%)       6 (12%)                  
      Red Pulp, Depletion Cellular                     3 (6%)       3 (6%)       2 (4%)       4 (8%)       2 (4%)                   
   Thymus                                             (46)         (44)         (45)         (46)         (41)                      
      Atrophy                                         40 (87%)     43 (98%)     44 (98%)     46 (100%)    41 (100%)                 
      Necrosis                                         1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (47)         (46)         (50)         (47)                      
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                     10 (22%)     21 (45%)     12 (26%)     12 (24%)     10 (21%)                  
      Mineralization                                                1 (2%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                                                                         2 (4%)                   
      Dermis, Fibrosis                                                           1 (2%)       1 (2%)                                
      Hair Follicle, Atrophy                                        1 (2%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Fibrous Osteodystrophy                           2 (4%)       4 (8%)       8 (16%)     11 (22%)      9 (18%)                  
      Fracture                                                                                             1 (2%)                   
      Necrosis                                         1 (2%)                                                                       
      Osteomalacia                                                 13 (26%)     12 (24%)      8 (16%)      3 (6%)                   
      Osteopetrosis                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Hemorrhage                                       2 (4%)                                              1 (2%)                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Cerebrum, Degeneration                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)                      
      Cyst, Squamous                                                                                       1 (2%)                   
      Foreign Body                                                  1 (2%)       2 (4%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)       2 (4%)       2 (4%)                   
      Inflammation                                    11 (22%)     13 (26%)     13 (26%)      8 (16%)     14 (28%)                  
      Mineralization                                   1 (2%)       2 (4%)       3 (6%)       7 (14%)      6 (12%)                  
      Necrosis                                                                                1 (2%)                                
      Pigmentation                                     3 (6%)       6 (12%)      4 (8%)       5 (10%)      5 (10%)                  
      Thrombosis                                       1 (2%)                                 2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 3 (6%)       9 (18%)      9 (18%)      7 (14%)      3 (6%)                   
      Mediastinum, Inflammation                                     1 (2%)                                                          
      Mediastinum, Thrombosis                                                                 1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)         (50)                      
      Foreign Body                                     4 (8%)       3 (6%)       7 (14%)      5 (10%)      6 (12%)                  
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation                                     4 (8%)       3 (6%)       8 (16%)      6 (12%)      6 (12%)                  
      Respiratory Epithelium, Inflammation             1 (2%)                                              3 (6%)                   
   Trachea                                            (50)         (50)         (50)         (50)         (49)                      
      Inflammation                                                               1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (4)          (5)          (2)                       
      Cataract                                         2 (100%)                  2 (50%)      4 (80%)                               
      Degeneration                                                                            1 (20%)                               
      Hemorrhage                                                                              2 (40%)                               
      Inflammation                                                               1 (25%)                   1 (50%)                  
      Mineralization                                                                          4 (80%)      1 (50%)                  
      Cornea, Inflammation                                                       1 (25%)      1 (20%)                               
      Retina, Degeneration                             2 (100%)                  3 (75%)      4 (80%)      1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Accumulation, Hyaline Droplet                    3 (6%)      14 (28%)     10 (20%)     16 (32%)     16 (32%)                  
      Cyst                                             3 (6%)       4 (8%)       9 (18%)      7 (14%)     13 (26%)                  
      Hydronephrosis                                   2 (4%)                    2 (4%)                    2 (4%)                   
      Infarct                                          1 (2%)                                              1 (2%)                   
      Inflammation                                     7 (14%)      5 (10%)      2 (4%)       5 (10%)      4 (8%)                   
      Mineralization, Diffuse                          3 (6%)       2 (4%)       9 (18%)      8 (16%)      6 (12%)                  
      Nephropathy                                     50 (100%)    50 (100%)    50 (100%)    50 (100%)    50 (100%)                 
      Pigmentation                                    25 (50%)     31 (62%)     36 (72%)     38 (76%)     33 (66%)                  
      Thrombosis                                                                              1 (2%)                                
      Medulla, Mineralization                         30 (60%)     42 (84%)     46 (92%)     47 (94%)     49 (98%)                  
      Renal Tubule, Hyperplasia                        3 (6%)       7 (14%)      3 (6%)       9 (18%)      9 (18%)                  
      Renal Tubule, Hyperplasia, Oncocytic                                                    1 (2%)       1 (2%)                   
      Transitional Epithelium, Hyperplasia            28 (56%)     45 (90%)     44 (88%)     48 (96%)     48 (96%)                  
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (49)                      
      Hemorrhage                                                                 2 (4%)                    1 (2%)                   
      Inflammation                                     8 (16%)      8 (16%)     11 (22%)      8 (16%)      9 (18%)                  
      Serosa, Inflammation                                                       1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 88036-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ANTHRAQUINONE                                       Date: 02/25/99  
Route: DOSED FEED                                                                                                 Time: 11:42:20  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        469 PPM      938 PPM      1875 PPM     3750 PPM                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------